Acanthosis nigricans

L12_ACANTHNIGRICANS

acanthosis nigricans: a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L83 Hospital discharge: ICD-9 — 7012A Hospital discharge: ICD-8 — 7011 Cause of death: ICD-10 — L83 Cause of death: ICD-9 — 7012A Cause of death: ICD-8 — 7011 2 out of 7 registries used, show all original rules.	124
4. Check minimum number of events None	124
5. Include endpoints None	124
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L80-L99
Name in latin: Acanthosis nigricans

NAME	L12_ACANTHNIGRICANS
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L83
HD_ICD_9	7012A
HD_ICD_8	7011
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L83
COD_ICD_9	7012A
COD_ICD_8	7011
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Acanthosis nigricans based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1289	650	620
Only index persons	1001	528	473
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	35.84	38.52	32.41
Only index persons	27.01	31.54	21.95

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	74	50
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	27.95	31.51	22.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
116: Matched controls
1162

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L83

ICD-10 Finland

Acanthosis nigricans

+∞

75.5

70119

ICD-8 Finland

Other hypertrophic and atrophic conditions of the skin, Keratosis, hyperkeratosis alia sive NUD

+∞

32.9

70115

ICD-8 Finland

Other hypertrophic and atrophic conditions of the skin, Ichthyosis

+∞

12.7

SPAT1148

SPAT

Treatment of chronic ulcer or burn

5.8

8.7

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

6.1

7.5

70110

ICD-8 Finland

Other hypertrophic and atrophic conditions of the skin, Keratoderma acquisitum (Kämmen, jalkapohja) (palmare, plantare)

+∞

7.4

E000001

ATC

3.4

6.7

136

J01FF01

ATC

clindamycin; systemic

3.1

6.6

179

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

5.01

13.04

2.6

1.5

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

9.80

8.20

1.3

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

101

3.60

7.73

10.3

4.5

1.1

1.0

mmol/l

0.63

(40768443) Skin Pathology biopsy report

5.03

6.66

1.6

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

419

2.54

6.06

9.8

5.3

1.2

mmol/l

0.14

350

(42870588) Differential panel, method unspecified - Blood

307

2.42

5.39

5.7

5.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

465

2.31

4.91

6.8

5.2

26.8

28.5

0.70

436

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

385

2.29

4.90

3.0

2.2

77.9

74.8

nmol/l

0.27

347

(3019225) pH of Specimen

3.17

4.84

7.0

3.3

—

(3018010) Neutrophils/100 leukocytes in Blood

459

2.28

4.79

6.5

5.2

59.9

56.6

1.77

431

(3006504) Eosinophils/100 leukocytes in Blood

447

2.23

4.56

7.0

5.3

2.5

2.8

0.71

417

(3019069) Monocytes/100 leukocytes in Blood

449

2.21

4.49

7.2

5.5

7.7

8.3

1.02

422

(3000494) Fungus identified in Specimen by Culture

2.81

4.27

2.2

1.4

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

111

2.57

3.87

3.6

2.0

23.1

25.9

0.38

(3022096) Basophils/100 leukocytes in Blood

429

2.02

3.60

7.3

5.4

0.8

0.7

0.91

400

(3001122) Ferritin [Mass/volume] in Serum or Plasma

430

2.01

3.57

3.3

2.7

136.2

99.6

ug/l

0.74

404

(3022313) Gas panel - Capillary blood

3.80

3.57

6.1

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

227

2.13

3.52

4.8

3.8

21.1

9.3

mg/mmol

0.67

132

(3042936) Bacteria identified in Isolate by Culture

116

2.45

3.52

2.4

2.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.53

3.06

1.1

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

207

2.04

3.02

2.3

1.9

3.5

2.9

mg/l

0.88

174

(3013115) Eosinophils [#/volume] in Blood

487

1.88

2.97

7.3

5.5

0.2

e9/l

0.56

426

(3019309) Folate [Moles/volume] in Red Blood Cells

147

2.17

2.96

1.9

1.6

970.5

1191.3

nmol/l

0.67

113

(3012516) Albumin [Mass/volume] in Urine

209

2.02

2.93

4.3

3.1

124.3

396.9

mg/l

0.38

122

(3001604) Monocytes [#/volume] in Blood

470

1.86

2.91

7.3

5.4

0.6

e9/l

0.42

401

(3003181) Sodium [Moles/volume] in Urine

6.94

2.90

1.2

1.6

51.8

61.8

mmol/l

—

(3019198) Lymphocytes [#/volume] in Blood

490

1.86

2.88

7.2

5.3

1.8

2.0

e9/l

0.62

430

(3006315) Basophils [#/volume] in Blood

472

1.85

2.86

7.4

5.4

0.0

e9/l

0.58

405

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

2.12

2.74

1.5

1.8

—

(3032080) INR in Blood by Coagulation assay

340

1.85

2.73

6.3

6.6

1.3

1.1

inr

0.44

112

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.42

2.73

1.4

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.42

2.73

1.4

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.67

2.57

2.5

3.3

64.3

62.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

5.67

2.57

2.5

3.1

5.0

6.7

e9/l

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

5.19

2.43

2.0

2.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

556

1.76

2.42

9.4

9.1

4.8

4.0

e9/l

0.88

475

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

151

2.01

2.41

3.4

3.0

224.9

73.8

ng/l

0.31

100

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.78

2.25

1.1

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.73

2.23

1.6

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

221

1.81

2.17

3.1

3.2

1608.9

836.4

ng/l

0.75

190

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

5.16

2.09

5.4

2.9

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

5.16

2.09

1.6

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

683

1.71

2.05

5.5

4.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.95

2.04

2.2

1.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

757

1.76

2.04

4.6

3.7

14.4

14.6

pmol/l

0.29

689

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.86

1.97

1.9

2.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.86

1.97

1.4

2.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

3.88

1.96

2.0

1.9

—

(3023368) Bacteria identified in Blood by Culture

229

1.74

1.91

6.5

4.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

102

890

1.82

1.78

7.7

4.8

40.3

39.2

mmol/mol

0.58

832

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.42

1.76

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

1.75

0.0

1.4

—

(3018418) pH of Serum or Plasma

269

1.66

1.74

8.1

3.5

7.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

1.73

0.0

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.69

1.69

1.4

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.90

1.67

8.7

2.1

22.2

25.1

mmol/l

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.67

1.63

1.8

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

327

1.59

1.62

4.9

3.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

206

1.67

1.58

1.6

1.8

0.6

1.1

mg/l

1.13

156

(3015377) Calcium [Moles/volume] in Serum or Plasma

321

1.57

1.55

2.5

2.8

2.4

mmol/l

0.28

293

(40760888) Immunoglobulin light chains.free panel - Serum

3.43

1.54

1.2

5.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.95

1.52

1.0

1.3

—

(3013512) EKG study

254

1.59

1.45

4.5

3.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.23

1.38

1.2

2.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.83

1.35

21.8

19.3

1.3

1.1

inr

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

339

1.51

1.35

2.3

1.7

88.1

95.2

pmol/l

0.47

157

(1761868) Lipid panel - Serum or Plasma

393

0.63

1.33

3.3

2.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.44

1.32

1.5

1.7

39.5

39.9

nmol/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.85

1.29

1.4

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.85

1.29

8.6

3.0

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.37

1.29

1.5

1.4

10.3

7.5

u/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

695

1.48

1.23

4.3

2.8

74.4

45.5

u/l

1.09

657

(3007164) IgA [Mass/volume] in Serum or Plasma

221

1.54

1.18

1.4

1.9

2.5

g/l

0.87

130

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.98

1.16

1.7

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.26

1.10

2.6

2.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

123

1.64

1.07

1.6

1.8

—

(3015736) pH of Urine

381

1.42

1.07

3.6

3.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.77

1.06

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

131

0.51

1.06

1.9

1.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.85

1.04

2.1

2.4

—

32.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

1.69

1.03

1.3

1.6

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.88

1.02

1.1

1.3

—

38.3

—

(3021589) Normoblasts [#/volume] in Blood

452

1.39

0.99

14.7

8.8

0.0

e9/l

0.74

365

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.70

0.99

4.3

3.2

—

(3000330) Specific gravity of Urine by Test strip

1.86

0.99

4.8

2.4

—

(40768797) Stomach Pathology biopsy report

110

1.63

0.97

1.1

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

102

1.65

0.96

1.3

1.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

249

1.44

0.96

1.3

0.7

1.1

u/ml

—

(3019060) Gas panel - Arterial blood

1.79

0.94

3.0

4.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

136

1.56

0.94

2.5

1.6

—

(3002256) Pathology report gross observation

112

1.60

0.90

1.5

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

2.05

0.88

6.8

3.1

—

(3035350) Ketones [Presence] in Urine by Test strip

490

1.35

0.85

3.7

3.5

0.0

estimate

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.98

0.85

1.0

—

20.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.98

0.85

1.0

1.2

—

(3012544) pH of Venous blood

1.71

0.85

3.2

—

(21494755) Public health laboratory ask at order entry panel

123

0.54

0.83

1.3

1.4

—

(3020891) Body temperature

1.92

0.83

2.8

3.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.75

0.82

1.0

2.3

0.1

e6/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

100

922

1.44

0.82

5.7

4.4

2.1

1.8

mu/l

1.31

851

(3011397) Hemoglobin [Presence] in Urine by Test strip

220

1.42

0.82

3.9

3.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.76

0.78

1.1

1.0

—

(3025941) Bacteria identified in Stool by Culture

1.76

0.78

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.72

0.76

1.7

1.2

—

(40768804) Tissue Pathology biopsy report

362

1.33

0.76

2.7

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

498

1.31

0.74

3.7

3.5

0.0

estimate

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

110

1.52

0.73

3.5

3.6

28.0

30.1

—

(3045414) Leukocytes [Presence] in Urine

1.79

0.72

2.3

1.5

—

(40758558) Short blood count panel - Blood

234

1.37

0.72

6.2

6.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

491

1.30

0.70

5.1

4.9

0.0

estimate

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.82

0.67

1.0

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

1.82

0.67

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

220

0.69

0.66

2.9

3.9

30.5

22.8

—

(3002582) Erythrocytes [#/volume] in Urine

303

1.32

0.65

3.2

2.8

19.2

24.4

e6/l

0.23

231

(3031040) Bacteria [#/volume] in Urine by Automated count

654

1.28

0.65

5.6

4.2

—

3504.6

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.60

0.64

3.1

3.0

6.1

5.7

kpa

1.20

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.75

0.64

1.0

1.1

—

(3026008) Bacteria identified in Urine by Culture

295

1.31

0.63

3.4

2.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.69

0.62

1.4

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

222

1.34

0.61

7.1

3.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

142

1.40

0.59

2.5

2.7

2.6

3.4

e6/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

151

1.39

0.58

2.4

2.6

0.6

0.9

e6/l

0.52

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

160

1.38

0.58

1.3

19.6

27.5

iu/ml

—

(3002385) Erythrocyte distribution width [Ratio]

885

0.78

0.58

25.4

14.8

13.7

13.6

0.27

870

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.61

0.55

3.8

2.6

62.2

48.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

100

942

1.32

0.54

16.6

11.2

84.8

87.3

ml/min/173m2

0.38

749

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.52

0.52

5.0

5.4

25.2

24.5

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

382

1.24

0.48

3.7

3.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

121

1.37

0.47

2.2

1.7

27.4

29.7

1.40

116

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.42

0.46

3.1

2.5

129.6

132.2

g/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

183

0.74

0.44

1.9

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

463

1.21

0.44

4.7

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.40

0.43

9.2

7.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.46

0.43

1.5

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

747

0.83

0.43

3.1

3.5

—

(3030467) Casts [#/volume] in Urine by Automated count

271

1.24

0.43

3.5

2.8

0.2

0.3

e6/l

0.57

200

(40761535) Cells panel - Urine sediment

1.47

0.43

9.2

3.7

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.49

0.41

1.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

226

1.25

0.40

2.2

2.0

—

(3018095) Leukocytes [#/volume] in Urine

350

1.21

0.40

3.7

3.5

14.3

48.5

e6/l

1.69

246

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.40

0.38

1.4

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

153

1.29

0.38

1.3

1.4

9.0

u/ml

—

(4010399)

1.42

0.38

1.4

1.3

—

(36660697) Celiac disease serology panel - Serum

1.35

0.37

1.1

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.63

0.37

1.2

1.4

—

(3008898) HLA-B27 [Presence]

1.45

0.36

1.0

1.2

—

(3000492) Spirometry study

1.35

0.35

1.5

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

174

1.25

0.34

1.8

2.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.32

0.33

6.0

7.5

93.0

94.4

—

(36304419) Bacteria [Presence] in Urine

270

1.20

0.32

3.5

2.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.71

0.32

1.6

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

311

1.17

0.29

2.2

2.1

—

(3029937) Albumin [Presence] in Urine by Test strip

254

1.18

0.28

3.7

0.0

estimate

—

(3022145) Colonoscopy Study observation

104

1.28

0.28

1.6

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

110

1070

1.25

0.27

23.1

13.5

81.8

74.1

umol/l

0.77

110

1070

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

189

1.20

0.26

1.9

2.4

—

(3011288) Drugs identified in Urine by Screen method

1.33

0.23

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

104

1010

1.18

0.23

23.0

11.9

19.8

22.9

mg/l

0.57

768

(3041096) Erythrocytes [Presence] in Urine by Automated

288

1.15

0.23

2.8

3.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.26

0.22

2.2

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.23

0.22

3.6

2.1

1.2

1.0

—

(3044889) 12 lead EKG panel

665

1.12

0.21

3.8

3.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

0.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.26

0.20

6.0

7.1

0.8

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.26

0.20

6.0

7.1

1.5

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

102

993

1.15

0.19

5.8

4.4

2.8

mmol/l

0.06

930

(3024354) Oxygen [Partial pressure] in Venous blood

1.20

0.18

4.0

2.4

5.1

4.5

kpa

—

(3000991) Gas panel - Venous blood

1.19

0.17

5.9

6.2

—

(4035726)

1.11

0.15

1.3

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

946

1.12

0.15

19.5

12.5

40.7

40.3

0.21

753

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

211

1.11

0.12

2.3

1.7

—

(3019150) Specific gravity of Urine by Refractometry

223

1.09

0.10

4.5

3.7

1.0

kg/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.14

0.10

7.8

6.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.12

0.10

1.8

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.79

0.08

2.8

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.06

0.07

1.9

3.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

236

1.07

0.07

2.1

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.02

0.07

3.0

1.7

—

(40761511) CBC panel - Blood by Automated count

106

1071

0.93

0.05

23.2

10.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

261

0.95

0.04

2.5

2.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

319

1.05

0.04

3.8

3.9

43.5

33.1

ng/l

0.29

202

(3003694) ABO and Rh group [Type] in Blood

310

0.96

0.03

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

967

0.97

0.01

6.4

3.9

6.1

5.8

mmol/l

0.96

900

(3019832) Treponema pallidum Ab [Presence] in Serum

174

0.97

0.00

1.9

1.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

105

1.05

0.00

3.2

1.9

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.9

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.8

—

35.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.8

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

129.5

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.3

—

6.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.92

0.00

2.7

2.5

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

176.5

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(4211845)

0.00

0.0

1.3

—

(4198724)

0.00

0.0

1.8

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACANTHNIGRICANS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_ACANTHNIGRICANS	1.857 [1.28, 2.7]	0.001
Birth year	0.999 [0.99, 1.01]	0.827

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 312 females with L12_ACANTHNIGRICANS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACANTHNIGRICANS.

N-year risk	Females	Males
1	0.187%	No data
5	1.092%	No data
10	2.893%	No data
15	5.937%	No data
20	10.56%	No data

Relationships between endpoints

↥

Index endpoint: L12_ACANTHNIGRICANS – Acanthosis nigricans

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acanthosis nigricans

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints