No definition available.
Congenital malformations of cardiac chambers and connections
Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
227 |
4. Check minimum number of eventsNone |
227 |
5. Include endpointsNone |
227 |
6. Filter based on genotype QC (FinnGen only) |
227 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae loculorum et connectionum cordis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of cardiac chambers and connections
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1715 | 717 | 996 |
| Only index persons | 1148 | 491 | 657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 2.36 | 3.16 | 1.67 |
| Only index persons | 8.28 | 9.82 | 7.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 227 | 97 | 130 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 8.78 | 9.12 | 8.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 1999
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
121.6
104
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
301.0
118.0
110
8
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
330.6
116.4
108
7
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
138.9
108.0
109
17
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
39.6
92.4
123
77
XF404
NOMESCO Finland
Ambulatory ECG
44.7
88.7
112
55
C03CA01
ATC
furosemide; systemic
38.8
84.4
111
62
C03DA01
ATC
spironolactone; oral
66.7
81.1
92
25
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
202.0
77.3
76
6
XF400
NOMESCO Finland
ECG with 12 standard connections
21.3
76.5
135
177
B01AA03
ATC
warfarin; systemic
48.5
76.4
93
35
XF402
NOMESCO Finland
ECG with work load test
45.6
73.0
90
35
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
155.4
70.3
71
7
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
19.9
68.0
116
129
C01AA05
ATC
digoxin; systemic
127.0
59.9
62
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
13.4
59.5
149
357
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
58.2
53
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
58.2
53
*
TPH07
NOMESCO Finland
Cathetrisation of artery
20.1
58.1
94
84
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
20.5
56.9
91
78
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
55.9
51
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
131.5
55.2
57
6
Q20.48
ICD-10 Finland
Single ventricle
+∞
51.3
47
*
FM2CE
NOMESCO Finland
NA
21.6
49.6
76
55
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
49.0
45
*
61
HP
Catheterization and pressure measurement of the left side of the heart
+∞
46.7
43
*
31
HP
Congenital heart failure surgery
+∞
46.7
43
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
35.8
45.8
59
23
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
45.6
42
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
522.0
44.0
42
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
11.5
43.3
92
137
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
181.1
42.6
43
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
84.5
42.1
46
7
WX408
NOMESCO Finland
General anesthesy, balanced
8.4
41.9
131
369
XF622
NOMESCO Finland
Measurement of minute volume of heart
+∞
39.9
37
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
+∞
37.7
35
*
62
HP
Catheterization and pressure measurement of the right side of the heart
+∞
36.6
34
*
XF600
NOMESCO Finland
Bloodpressure measurement
10.7
35.2
75
106
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
34.3
32
*
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
33.2
31
*
G04BE03
ATC
sildenafil; oral
196.0
32.7
33
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
6.4
31.1
107
303
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
81.2
31.0
34
5
Z98.8
ICD-10 Finland
Other specified postsurgical states
98.2
30.8
33
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
16.7
30.5
50
39
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
29.9
28
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
29.9
28
*
207
Kela drug reimbursment
Chronic arrhythmias
30.8
28.7
38
15
C09AA02
ATC
enalapril; systemic
13.6
28.4
51
49
R4110
NOMESCO Finland
Physiotherapy
5.7
27.9
106
328
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
27.7
26
*
C01BD01
ATC
amiodarone; systemic
310.0
27.4
27
*
TFP20
NOMESCO Finland
Cardiodefibrillation
54.0
27.4
32
7
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
26.6
25
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
20.7
26.1
39
23
WX892
NOMESCO Finland
Monitored bed care
10.9
25.9
52
62
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
25.5
24
*
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
24.5
23
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
23.4
22
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
46.0
23.3
28
7
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
59.3
22.7
26
5
WX882
NOMESCO Finland
High dependency care
7.2
22.6
60
112
C07AB07
ATC
bisoprolol; oral
5.9
21.8
70
167
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
21.2
20
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
21.2
20
*
I49.5
ICD-10 Finland
Sick sinus syndrome
232.9
21.0
21
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
20.1
19
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
45.0
20.0
24
6
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
19.0
18
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
19.0
18
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
19.0
18
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
19.0
18
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
19.0
18
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
208.5
18.9
19
*
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
208.5
18.9
19
*
I50.9
ICD-10 Finland
Heart failure, unspecified
17.8
18.1
28
18
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
18.0
17
*
ZX120
NOMESCO Finland
Intravenous
6.6
17.5
48
91
WX872
NOMESCO Finland
Intensive care
19.7
17.5
26
15
I47.1
ICD-10 Finland
Supraventricular tachycardia
12.4
17.2
31
29
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
16.9
16
*
WX704
NOMESCO Finland
Intubation
8.5
16.5
37
52
XFE00
NOMESCO Finland
Epicardial ultrasonography
23.4
16.4
23
11
7AX01
NOMESCO Finland
NA
52.1
16.3
19
*
C07AA07
ATC
sotalol; systemic
52.1
16.3
19
*
C09AA05
ATC
ramipril; oral
8.8
16.0
35
47
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
+∞
15.8
15
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
15.8
15
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
15.8
15
*
ZX199
NOMESCO Finland
Other rote
22.2
15.5
22
11
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
14.8
14
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
14.8
14
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
14.8
14
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
14.8
14
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
14.8
14
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
14.8
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
14.1
61
190
C07AB02
ATC
metoprolol; systemic
6.7
13.8
36
63
XF640
NOMESCO Finland
NA
80.7
13.8
15
*
XF620
NOMESCO Finland
Examination of circulation with color method
+∞
13.7
13
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
13.7
13
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
13.7
13
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
13.7
13
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
13.7
13
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
13.7
13
*
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
+∞
13.7
13
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
13.7
13
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
28.0
13.6
18
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.0
13.4
60
191
I44.2
ICD-10 Finland
Atrioventricular block, complete
34.5
12.8
16
5
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
12.6
12
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
12.6
12
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
12.6
12
*
C02EA02
ATC
NA
+∞
12.6
12
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
12.6
12
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
12.6
12
*
XQ903
NOMESCO Finland
Production of other scan or drawing
138.1
12.6
13
*
AN1
HP
Coronary angiography
23.0
12.2
17
8
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.9
12.0
54
171
Z94.1
ICD-10 Finland
Heart transplant status
32.2
11.8
15
5
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
69.0
11.7
13
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
11.6
11
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
11.6
11
*
AP2
HP
Catheterization of the right side of the heart
+∞
11.6
11
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
11.6
11
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
11.6
11
*
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
11.6
11
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
11.6
11
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
11.6
11
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
11.6
11
*
ZX108
NOMESCO Finland
Inhalation
15.1
11.2
18
13
RS224
NOMESCO Finland
NA
16.7
11.0
17
11
I50.0
ICD-10 Finland
Congestive heart failure
29.9
10.9
14
5
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
63.4
10.7
12
*
R07.4
ICD-10 Finland
Chest pain, unspecified
3.8
10.6
48
152
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
5.8
10.5
30
59
1EA01
NOMESCO Finland
NA
115.7
10.5
11
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
10.5
10
*
Q20.9
ICD-10 Finland
Congenital malformation of cardiac chambers and connections, unspecified
+∞
10.5
10
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
10.5
10
*
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
+∞
10.5
10
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
10.5
10
*
B34.9
ICD-10 Finland
Viral infection, unspecified
6.1
10.3
28
52
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
10.1
61
240
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
21.3
9.9
14
7
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.9
9.6
72
324
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.1
9.6
23
36
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
9.4
9.5
19
22
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
23.0
9.5
13
6
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
23.0
9.5
13
6
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
9.4
9
*
3A077
NOMESCO Finland
NA
+∞
9.4
9
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
9.4
9
*
Q20.60
ICD-10 Finland
Left isomerism of atrial appendages
+∞
9.4
9
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
9.4
9
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
9.4
9
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
+∞
9.4
9
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
9.4
9
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
9.4
9
*
FM1BD
NOMESCO Finland
Extensive CT of heart
+∞
9.4
9
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
9.4
9
*
UGC02
NOMESCO Finland
Rigid bronchoscopy
16.6
9.2
14
9
I50.1
ICD-10 Finland
Left ventricular failure
19.7
9.1
13
7
205
Kela drug reimbursment
Chronic hypertension
5.0
8.8
28
63
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
8.7
51
195
602
Kela drug reimbursment
Children's severe malnutrition
5.8
8.6
24
46
RK260
NOMESCO Finland
NA
21.1
8.6
12
6
XG460
NOMESCO Finland
Short time oxymetry
93.7
8.5
9
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
93.7
8.5
9
*
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
93.7
8.5
9
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
93.7
8.5
9
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
93.7
8.5
9
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
8.4
8
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
8.4
8
*
324
NOMESCO Finland
NA
+∞
8.4
8
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
+∞
8.4
8
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
8.4
8
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
8.4
8
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
8.4
8
*
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
+∞
8.4
8
*
FFE02
NOMESCO Finland
Percutaneous transluminal atrial septostomy
+∞
8.4
8
*
7453B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common ventricle[COMMON VENTRICLE]
+∞
8.4
8
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
+∞
8.4
8
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.4
8.2
14
12
TFP35
NOMESCO Finland
Electroanatomical mapping
34.8
8.1
10
*
WX402
NOMESCO Finland
General anaesthesia
2.7
7.9
61
276
WX002
NOMESCO Finland
Sedation and analgesia
3.6
7.8
36
115
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
46.8
7.8
9
*
1CX08
NOMESCO Finland
NA
46.8
7.8
9
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
7.3
7
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
7.3
7
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
7.3
7
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
7.3
7
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
7.3
7
*
AP3
HP
Catheterization of the right and left side of the heart
+∞
7.3
7
*
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
+∞
7.3
7
*
FFK20
NOMESCO Finland
Atrio-pulmonary anastomosis
+∞
7.3
7
*
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
7.3
7
*
K83
ICPC
Heart valve disease NOS
+∞
7.3
7
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
7.3
7
*
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
7.3
7
*
Q20.41
ICD-10 Finland
Double inlet right ventricle
+∞
7.3
7
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
7.3
7
*
AF1
HP
Surgery of congenital heart defect
+∞
7.3
7
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
7.3
60
279
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.6
7.2
24
57
WX870
NOMESCO Finland
Other postsurgical intensive care
31.2
7.2
9
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
31.2
7.2
9
*
J01CA04
ATC
amoxicillin; systemic
3.7
7.2
186
1558
B01AB05
ATC
enoxaparin; parenteral
3.3
7.2
36
123
R04.0
ICD-10 Finland
Epistaxis
5.7
7.0
19
36
TFP34
NOMESCO Finland
Electrophysiological investigation
9.8
6.9
13
14
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.4
6.9
24
60
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.4
6.8
73
390
I47.2
ICD-10 Finland
Ventricular tachycardia
17.4
6.8
10
6
K84
ICPC
Heart disease other
41.4
6.8
8
*
GD1LA
NOMESCO Finland
GD
23.4
6.7
9
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.4
6.7
19
38
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
12.8
6.7
11
9
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
12.8
6.7
11
9
5253
FHL
Cardiac lung machine
71.9
6.5
7
*
ZXA00
NOMESCO Finland
Right side
2.8
6.5
43
177
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.0
6.3
19
41
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
6.3
6
*
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
+∞
6.3
6
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
6.3
6
*
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
6.3
6
*
3A566
NOMESCO Finland
NA
+∞
6.3
6
*
7452B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[DOUBLE OUTLET RIGHT VENTRICLE AND PULMONAL STENOSIS]
+∞
6.3
6
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
6.3
6
*
5401
FHL
Pacemaker installation, transvenous electrode
+∞
6.3
6
*
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
+∞
6.3
6
*
Q20.4
ICD-10 Finland
Double inlet ventricle
+∞
6.3
6
*
5233
FHL
Right ventricular bypass surgery (Fontan et al.)
+∞
6.3
6
*
I97.0
ICD-10 Finland
Postcardiotomy syndrome
+∞
6.3
6
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
6.3
6
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
6.3
6
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
6.3
6
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
6.3
6
*
I48.4
ICD-10 Finland
Atypical atrial flutter
+∞
6.3
6
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
6.3
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.3
6
*
7468X
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[MUU SYDÄMEN EPÄMUODOSTUMA]
+∞
6.3
6
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
27.6
6.3
8
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
27.6
6.3
8
*
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
5.9
6.1
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
155
50
95.58
259.38
6.8
7.0
156.2
164.8
ng/l
0.05
146
44
119
187
12.27
81.85
7.7
3.3
3164.5
212.3
ng/l
2.18
104
99
61
32
25.70
80.87
4.0
6.3
73.3
100.2
%
3.11
61
32
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
56
34
21.54
69.16
17.5
20.7
0.3
0.3
u/ml
0.10
40
22
72
99
10.19
52.93
5.8
8.6
179.9
167.8
%
0.52
72
99
101
207
7.99
52.43
3.8
3.1
20.4
23.9
%
1.65
92
197
102
224
7.45
49.15
4.0
3.0
2.5
2.5
g/l
0.64
102
216
127
346
7.06
49.05
4.2
3.4
—
—
—
0
0
41
39
12.61
38.68
1.5
1.5
—
—
—
0
0
101
295
5.37
34.00
5.7
4.6
1.9
1.2
mg/l
0.92
77
214
101
295
5.37
34.00
5.6
3.0
34.4
24.7
ng/l
0.37
63
138
147
611
4.99
31.14
5.3
4.7
—
—
—
0
0
45
74
7.34
27.45
34.6
9.6
2.3
1.2
inr
—
9
15
106
392
4.20
25.03
4.0
3.6
3.6
2.6
mg/l
1.19
99
347
50
110
5.55
22.54
29.9
18.0
0.1
0.2
mmol/l
0.08
45
93
220
1647
11.88
20.29
40.8
13.5
4.0
4.0
mmol/l
2.64
220
1589
220
1647
11.88
20.29
40.6
13.4
139.2
139.5
mmol/l
1.48
220
1595
38
77
5.73
18.58
37.7
17.8
0.7
0.7
%
0.72
38
77
38
77
5.73
18.58
37.7
17.8
1.1
1.2
%
0.47
38
77
15
10
15.99
16.91
1.7
2.3
170.3
124.1
%
—
15
10
88
370
3.25
15.80
26.4
16.5
25.5
24.6
mmol/l
1.63
88
370
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
16
14
12.22
15.48
1.6
2.1
129.1
124.4
%
0.08
16
14
83
343
3.24
15.26
9.4
11.3
1.1
1.1
mmol/l
0.03
69
265
55
182
3.67
14.30
2.9
1.8
—
—
—
0
0
54
182
3.58
13.61
3.2
1.9
—
—
—
0
0
79
340
3.03
13.29
20.0
10.3
1.8
0.9
mmol/l
2.37
67
253
79
342
3.01
13.13
20.2
10.2
5.2
5.1
kpa
0.57
79
329
72
301
3.04
12.67
20.2
10.4
8.7
9.7
kpa
2.73
72
290
59
228
3.15
11.82
3.3
2.0
—
—
—
0
0
13
5
27.42
9.92
2.9
13.6
—
—
—
0
0
20
40
5.39
9.76
2.2
2.3
1.0
1.1
g/l
0.06
15
35
21
48
4.72
8.82
2.2
2.0
—
—
—
0
0
160
1143
2.35
7.97
23.3
7.9
100.8
101.0
ml/min/173m2
0.04
135
836
12
18
6.98
7.68
1.2
1.2
80.6
94.9
%
0.52
12
18
16
33
5.14
7.53
1.4
1.2
7.0
2.9
u/ml
—
8
15
16
33
5.14
7.53
1.4
1.2
1.5
1.6
u/ml
—
6
16
24
70
3.72
7.35
2.7
2.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
10
13
8.00
7.17
2.3
1.1
57.0
115.5
%
—
10
13
11
8
14.36
6.96
1.6
1.3
13.0
9.0
umol/l
—
11
8
11
8
14.36
6.96
1.1
1.1
80.3
100.8
%
—
11
8
20
54
3.96
6.80
9.9
12.5
22.5
23.7
mmol/l
1.12
20
49
20
54
3.96
6.80
1.5
5.1
—
—
—
0
0
21
59
3.82
6.77
2.1
2.1
—
—
—
0
0
23
71
3.49
6.48
4.1
2.4
68.3
88.2
ml/min/173m2
—
10
26
23
73
3.39
6.21
2.7
2.5
—
—
—
0
0
155
1154
2.08
6.13
13.5
13.0
3.7
3.6
e9/l
0.33
146
962
213
1821
3.75
6.11
30.5
11.5
24.2
21.9
mg/l
0.50
175
1270
14
31
4.75
6.07
1.3
1.2
—
—
—
0
0
23
81
3.05
5.26
2.5
1.5
—
—
—
0
0
8
6
13.75
5.11
1.4
1.2
—
—
—
0
0
11
23
4.98
5.07
1.7
1.4
—
—
—
0
0
215
1890
3.60
5.02
43.6
14.9
40.0
40.3
%
0.33
203
1685
17
51
3.52
4.99
2.1
2.2
—
—
—
0
0
87
575
1.83
4.48
4.8
4.6
—
—
—
0
0
5
211
0.22
4.24
1.0
1.1
—
—
—
0
0
19
69
2.91
4.13
16.4
11.8
1796.0
425.3
iu/ml
—
5
12
77
504
1.80
4.02
4.7
4.3
0.5
0.3
e6/l
0.64
58
370
16
54
3.11
3.93
1.3
4.7
0.3
0.2
e9/l
0.65
11
38
57
342
1.89
3.91
2.9
3.8
2.2
1.6
e6/l
0.31
30
205
11
29
3.94
3.85
1.3
1.4
—
—
—
0
0
19
72
2.79
3.84
1.8
1.3
—
—
—
0
0
19
72
2.79
3.84
1.8
1.3
—
—
—
0
0
15
50
3.14
3.76
1.3
4.9
13.9
27.7
%
5.32
15
50
21
87
2.56
3.59
3.0
2.7
—
—
—
0
0
55
339
1.82
3.44
3.1
3.8
0.5
0.6
e6/l
0.03
28
201
9
18
5.16
3.40
8.2
13.1
2.5
2.1
mg/l
—
9
13
23
103
2.37
3.35
1.6
1.9
—
—
—
0
0
15
54
2.90
3.32
14.1
5.6
53.1
63.2
%
0.62
15
54
12
38
3.28
3.26
1.7
1.6
—
—
—
0
0
22
98
2.38
3.25
1.9
1.8
—
—
—
0
0
16
62
2.70
3.12
9.3
12.7
—
2462.3
—
0
10
9
21
4.42
3.03
1.4
1.8
—
—
—
0
0
5
5
10.18
2.99
1.4
1.6
—
—
—
0
0
160
1815
0.60
2.95
3.9
3.9
—
—
—
0
0
10
31
3.33
2.81
1.9
5.3
56.3
49.3
%
—
10
31
17
72
2.47
2.80
2.4
1.4
—
—
—
0
0
22
105
2.21
2.79
2.8
1.9
—
—
—
0
0
48
713
0.59
2.75
1.5
1.8
0.3
3.0
u/ml
—
6
132
13
49
2.75
2.67
1.4
1.7
—
—
—
0
0
8
20
4.11
2.59
1.5
1.8
—
—
—
0
0
11
39
2.91
2.51
1.9
2.0
—
—
—
0
0
7
16
4.48
2.49
2.6
1.5
—
—
—
0
0
6
13
4.71
2.28
1.8
1.8
—
—
—
0
0
0
56
0.00
2.09
0.0
2.1
—
—
—
0
0
12
52
2.38
1.91
2.0
1.8
—
—
—
0
0
5
12
4.23
1.83
2.4
1.4
—
—
—
0
0
17
89
1.98
1.75
9.1
4.0
—
—
—
0
0
0
47
0.00
1.72
0.0
1.2
—
—
—
0
0
5
14
3.63
1.62
1.6
2.0
—
—
—
0
0
5
14
3.63
1.62
1.6
2.0
—
—
—
0
0
5
14
3.63
1.62
1.6
2.0
—
—
—
0
0
16
85
1.95
1.59
1.3
1.4
—
—
—
0
0
10
47
2.18
1.36
1.0
1.0
156.2
163.7
g/l
—
10
47
5
116
0.42
1.29
1.2
1.4
—
—
—
0
0
12
63
1.96
1.25
1.5
1.2
—
—
—
0
0
6
25
2.44
1.25
5.0
6.3
—
—
—
0
0
9
168
0.52
1.24
1.4
1.5
—
—
—
0
0
11
56
2.01
1.24
1.1
3.3
—
—
—
0
0
0
34
0.00
1.17
0.0
1.1
—
—
—
0
0
0
34
0.00
1.17
0.0
1.1
—
—
—
0
0
0
34
0.00
1.17
0.0
1.1
—
—
—
0
0
7
31
2.30
1.11
1.4
1.5
—
—
—
0
0
6
124
0.47
1.08
1.2
2.0
—
—
—
0
0
18
114
1.63
1.06
2.3
2.1
—
—
—
0
0
5
22
2.30
1.04
1.6
2.3
0.0
0.0
g/l
—
5
22
5
22
2.30
1.04
1.6
2.3
0.0
0.0
g/l
—
5
22
5
23
2.20
0.98
1.6
2.3
0.0
0.0
g/l
—
5
23
12
69
1.78
0.98
4.6
3.9
1.3
1.2
mmol/l
0.79
12
57
6
29
2.10
0.90
2.2
1.8
—
—
—
0
0
24
174
1.42
0.81
3.4
2.7
31.9
33.1
u/l
0.06
19
147
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
9
53
1.73
0.76
2.7
1.8
—
—
—
0
0
5
25
2.02
0.73
1.6
2.2
—
—
—
0
0
5
27
1.87
0.69
1.8
1.8
—
—
—
0
0
8
131
0.60
0.65
1.0
1.2
—
—
—
0
0
10
153
0.64
0.65
1.4
1.3
85.9
166.3
iu/ml
—
5
51
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
43
506
0.81
0.55
4.3
3.1
—
—
—
0
0
18
234
0.75
0.51
1.2
1.3
10.0
19.0
iu/ml
—
6
59
117
1254
0.86
0.50
3.4
2.8
5.5
5.6
mmol/l
0.56
110
1163
8
116
0.68
0.47
1.1
1.3
—
—
—
0
0
14
184
0.75
0.44
2.0
2.1
13.2
13.3
nmol/l
0.02
14
159
35
409
0.83
0.42
1.8
2.2
—
—
—
0
0
16
205
0.76
0.42
1.8
1.8
—
—
—
0
0
5
33
1.53
0.41
5.8
4.9
22.0
27.3
umol/l
—
5
33
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
74.0
—
0
10
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
12.6
—
0
5
0
16
0.00
0.41
0.0
7.0
—
—
—
0
0
0
16
0.00
0.41
0.0
7.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
0.7
—
0
10
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
2.3
—
0
11
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
3.1
—
757.7
—
0
18
6
41
1.48
0.36
2.2
2.3
—
—
—
0
0
25
211
1.21
0.33
1.2
1.4
—
—
—
0
0
133
1268
1.12
0.33
4.3
3.0
1.3
1.3
mmol/l
0.02
126
1204
27
235
1.17
0.27
3.3
2.8
353.0
337.6
nmol/l
0.15
27
222
11
137
0.79
0.25
1.2
1.2
—
—
—
0
0
21
242
0.85
0.23
1.7
2.0
—
—
—
0
0
40
363
1.12
0.23
1.9
1.6
86.7
96.6
pmol/l
0.82
24
193
5
39
1.29
0.23
1.8
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
26.9
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
2.0
—
0
8
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
41
444
0.91
0.19
1.9
2.4
—
—
—
0
0
37
340
1.11
0.18
4.1
3.6
0.2
0.0
estimate
0.47
13
119
13
152
0.85
0.17
1.3
1.5
—
—
—
0
0
5
67
0.74
0.17
1.0
1.7
—
—
—
0
0
5
68
0.73
0.17
2.4
2.0
1.8
0.4
nmol/l
—
5
59
6
79
0.75
0.16
1.0
1.7
—
—
—
0
0
6
79
0.75
0.16
1.8
1.3
44.8
31.9
nmol/l
—
6
79
135
1326
1.04
0.09
4.3
3.2
2.6
2.8
mmol/l
1.88
128
1251
7
67
1.05
0.08
1.0
1.1
—
—
—
0
0
134
1319
1.04
0.07
4.3
3.1
1.2
1.4
mmol/l
7.35
129
1250
10
112
0.89
0.07
1.7
1.6
—
—
—
0
0
9
85
1.06
0.07
1.3
1.6
—
—
—
0
0
16
172
0.92
0.06
1.6
2.7
0.5
1.2
ug/l
5.23
11
160
74
756
0.97
0.05
4.1
3.4
0.0
0.0
estimate
0.00
12
115
149
1506
0.97
0.05
4.7
4.0
2.2
1.9
mu/l
1.83
142
1416
128
1292
0.98
0.03
4.2
3.7
15.7
14.4
pmol/l
6.29
121
1200
74
750
0.98
0.02
5.7
5.0
0.0
0.0
estimate
0.00
14
123
23
238
0.96
0.02
4.1
4.7
25.3
15.7
mg/mmol
0.35
18
173
74
746
0.99
0.00
1.9
1.9
—
—
—
0
0
115
1146
1.01
0.00
4.0
3.8
35.2
37.8
mmol/mol
4.10
110
1093
75
749
1.00
0.00
4.1
3.3
0.0
0.0
estimate
0.00
14
118
10
97
1.03
0.00
1.0
1.0
21.6
19.2
mmol/l
—
10
97
7
79
0.88
0.00
1.6
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
74
0.94
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
79
0.88
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
18.3
—
0
5
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
4.0
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
79
0.88
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
21.7
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
74.0
—
0
5
7
69
1.01
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO | 9.355 [4.38, 19.97] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.586 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 576 females with Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO | 7.222 [4.72, 11.04] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 760 males with Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.913% | 1.304% |
| 5 | 6.522% | 6.938% |
| 10 | 15.52% | 17.531% |
| 15 | 25.751% | 31.095% |
| 20 | 40.699% | 46.393% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO – Congenital malformations of cardiac chambers and connections
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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