≡ Risteys
FG R12 + FR

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Other mycoses, not elsewhere classified/unspecified

Endpoint Browser PheWeb

AB1_MYSOSIS_NOS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B48, B49
  • Hospital discharge: ICD-9 — 11[7-9]
  • Hospital discharge: ICD-8 — 117
  • Hospital discharge: excluded ICD-9 — 117[1-5]
  • Hospital discharge: excluded ICD-8 — 117[1-3]
  • Cause of death: ICD-10 — B48, B49
  • Cause of death: ICD-9 — 11[7-9]
  • Cause of death: ICD-8 — 117
  • Cause of death: excluded ICD-9 — 117[1-5]
  • Cause of death: excluded ICD-8 — 117[1-3]

2 out of 7 registries used, show all original rules.

104

4. Check minimum number of events

None

104

5. Include endpoints

None

104

6. Filter based on genotype QC (FinnGen only)

104

Control definitions (FinnGen only)

Control exclude
AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1022 457 554
Only index persons 724 330 394
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.01 0.01 0.02
Median age at first event (years)
Whole population 56.38 57.52 55.64
Only index persons 53.71 56.31 51.53

-FinnGen-

Key figures

All Female Male
Number of individuals 104 48 56
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 60.41 56.72 63.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B49
ICD-10 Finland
Unspecified mycosis
+∞
35.9
32
*
B48.8
ICD-10 Finland
Other specified mycoses
238.8
19.3
19
*
B48.7
ICD-10 Finland
Opportunistic mycoses
+∞
18.4
17
*
J02AC03
ATC
voriconazole; systemic
+∞
12.8
12
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.4
11.6
43
132
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.7
10.8
21
25
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
13.7
9.5
16
14
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.4
9.3
19
25
XW000
NOMESCO Finland
Bone marrow biopsy
11.0
8.2
15
16
TGC00
NOMESCO Finland
Bronchial lavation
20.7
7.8
11
6
A04AA01
ATC
ondansetron; systemic, rectal
9.3
7.5
15
19
11799
ICD-8 Finland
Other systemic mycosis, Unspecified
+∞
7.4
7
*
127
Kela drug reimbursment
Transplant complication
22.2
7.3
10
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.3
7.1
22
52
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.3
6.9
16
26
A41.8
ICD-10 Finland
Other specified sepsis
24.8
6.8
9
*
L03AA02
ATC
filgrastim; parenteral
13.7
6.8
11
9
D64.9
ICD-10 Finland
Anaemia, unspecified
5.4
6.7
20
45
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
6.3
6
*
R50.9
ICD-10 Finland
Fever, unspecified
4.3
6.1
23
67

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
107
7.19
21.92
4.6
1.3
—
—
—
0
0
35
62
8.00
20.60
6.9
2.6
8.1
9.7
g/l
1.11
35
57
15
10
17.36
17.10
3.1
2.1
—
—
—
0
0
15
10
17.36
17.10
3.1
2.1
—
—
—
0
0
15
10
17.36
17.10
3.1
2.1
—
—
—
0
0
15
10
17.36
17.10
3.1
2.1
—
—
—
0
0
33
70
6.44
16.03
5.0
3.0
79.0
69.9
e9/l
0.49
28
50
41
114
5.29
14.68
4.2
1.8
—
—
—
0
0
13
10
14.71
13.62
2.5
3.1
—
—
—
0
0
34
91
5.07
12.53
21.9
6.8
2.2
1.0
mmol/l
0.52
27
70
56
222
4.30
12.37
13.4
4.6
—
—
—
0
0
16
20
9.27
12.23
1.6
1.3
—
—
—
0
0
23
49
5.74
10.85
9.6
3.7
—
—
—
0
0
35
107
4.42
10.78
17.4
5.8
1.1
1.0
mmol/l
0.25
35
102
27
67
5.09
10.75
8.1
3.6
1.1
1.0
%
0.02
15
25
24
57
5.17
10.01
8.3
3.7
0.8
0.4
%
0.53
13
15
58
266
3.67
9.81
21.6
5.5
—
—
—
0
0
27
74
4.58
9.46
10.6
3.8
2.3
2.1
mmol/l
0.05
20
57
27
75
4.51
9.30
11.0
3.8
—
—
—
0
0
16
28
6.57
9.11
1.7
1.3
—
—
—
0
0
10
10
10.96
8.78
6.8
3.4
—
—
—
0
0
13
9
16.27
8.46
1.2
1.7
—
—
—
0
0
68
371
3.41
8.27
20.6
5.5
2.2
2.7
%
1.31
63
349
10
11
9.95
8.22
8.0
3.5
—
—
—
0
0
22
57
4.63
8.20
7.1
3.7
0.0
0.5
%
0.56
12
19
69
383
3.38
8.09
20.9
5.7
24.0
27.8
%
1.47
64
360
11
6
20.25
7.78
3.7
1.7
—
—
—
0
0
11
15
8.08
7.71
5.5
6.6
—
—
—
0
0
7
0
+∞
7.37
3.3
0.0
—
—
—
0
0
22
69
3.78
6.30
34.7
7.3
—
—
—
0
0
22
70
3.72
6.17
1.8
1.3
—
—
—
0
0
20
60
3.89
6.09
8.1
3.8
0.2
0.2
%
0.01
13
21
10
9
12.13
5.93
1.3
1.0
—
—
—
0
0
17
46
4.22
5.92
38.2
6.0
—
—
—
0
0
26
97
3.24
5.70
4.2
1.6
—
—
—
0
0
13
29
4.98
5.69
2.8
1.3
—
—
—
0
0
36
173
2.65
4.95
2.0
1.9
—
—
—
0
0
9
10
9.72
4.89
5.0
2.5
—
—
—
0
0
44
236
2.50
4.80
5.8
3.2
—
—
—
0
0
11
25
4.80
4.68
1.2
1.2
—
—
—
0
0
26
113
2.73
4.29
4.5
2.2
31.9
22.5
%
1.18
21
102
30
141
2.58
4.24
6.2
3.3
568.2
205.5
ng/l
0.52
24
106
16
55
3.26
3.94
13.3
4.9
25.3
24.7
mmol/l
0.26
16
55
28
133
2.51
3.85
1.8
1.7
—
—
—
0
0
7
8
9.27
3.83
1.3
1.0
—
—
—
0
0
7
8
9.27
3.83
1.9
1.9
—
—
—
0
0
7
8
9.27
3.83
1.1
1.1
—
—
—
0
0
24
107
2.62
3.74
1.8
1.5
—
—
—
0
0
23
101
2.64
3.69
8.1
3.1
5.9
6.3
umol/l
0.08
23
89
35
189
2.28
3.60
5.6
1.9
2.5
1.2
mg/l
0.76
28
145
12
36
3.64
3.60
12.3
2.7
1.9
1.5
%
0.40
12
36
9
17
5.68
3.60
3.3
1.6
—
—
—
0
0
6
6
10.50
3.54
1.0
1.3
—
—
—
0
0
36
199
2.24
3.49
23.3
7.5
—
—
—
0
0
35
192
2.24
3.46
5.9
3.7
—
—
—
0
0
19
78
2.76
3.45
1.7
1.4
—
—
—
0
0
8
14
6.09
3.41
16.6
2.4
—
—
—
0
0
44
266
2.13
3.41
9.5
2.4
—
—
—
0
0
51
329
2.08
3.31
14.7
6.4
1.1
1.2
inr
2.09
11
103
32
175
2.20
3.15
2.2
1.4
2.2
2.3
g/l
0.17
24
109
17
69
2.75
3.15
1.6
1.6
—
—
—
0
0
33
183
2.18
3.14
11.5
5.0
—
—
—
0
0
14
51
3.02
3.13
5.4
3.5
—
—
—
0
0
7
12
6.16
3.07
1.1
1.0
—
—
—
0
0
9
21
4.59
3.07
6.8
4.7
—
—
—
0
0
5
5
10.41
3.01
1.0
1.0
—
—
—
0
0
6
9
6.99
2.91
3.7
4.9
—
—
—
0
0
48
315
1.97
2.87
2.4
1.9
93.9
97.4
pmol/l
0.14
29
162
8
18
4.72
2.86
1.0
1.2
—
—
titre
—
0
0
15
61
2.70
2.76
3.9
4.0
—
—
—
0
0
13
49
2.89
2.74
2.2
2.5
3.5
3.7
e9/l
—
8
42
79
625
2.10
2.66
7.4
3.6
19.1
11.5
mm/h
2.68
74
566
9
26
3.69
2.55
8.6
4.0
—
—
—
0
0
73
569
1.95
2.47
9.1
4.1
—
—
—
0
0
11
40
2.96
2.46
7.8
3.5
—
—
—
0
0
6
12
5.23
2.44
1.2
1.0
—
—
—
0
0
38
242
1.90
2.40
12.6
4.4
7.4
7.4
ph
—
8
44
46
313
1.84
2.36
5.1
3.5
—
—
—
0
0
27
154
2.02
2.33
2.0
1.6
1243.0
1208.9
nmol/l
0.07
22
113
7
18
4.09
2.29
1.6
1.4
—
—
—
0
0
69
543
1.80
2.10
9.0
4.2
—
68.7
—
0
10
39
263
1.77
2.00
6.0
3.0
2.3
2.4
mmol/l
1.21
34
231
7
21
3.50
2.00
7.1
1.7
—
—
—
0
0
5
11
4.71
1.96
1.8
1.4
—
—
—
0
0
9
35
2.72
1.85
14.8
2.7
0.6
0.7
%
—
9
35
54
408
1.67
1.80
5.4
3.6
0.0
0.0
estimate
—
8
79
43
309
1.67
1.71
8.2
3.6
84.8
69.2
e6/l
0.08
35
214
44
321
1.64
1.64
3.2
2.2
—
—
—
0
0
53
407
1.62
1.60
8.4
4.9
0.0
0.0
estimate
—
8
77
27
175
1.73
1.55
4.9
2.2
3.3
4.0
e6/l
0.32
27
150
35
244
1.65
1.54
1.6
1.4
—
—
—
0
0
38
271
1.63
1.53
6.8
3.0
58.1
284.2
e6/l
0.45
32
203
53
412
1.58
1.49
5.5
3.6
0.0
0.0
estimate
—
8
73
5
16
3.23
1.45
1.2
1.8
—
—
—
0
0
14
77
1.95
1.33
12.6
5.8
—
—
—
0
0
6
25
2.48
1.26
7.3
1.9
5.1
5.0
kpa
—
6
25
6
25
2.48
1.26
7.3
1.9
7.7
8.6
kpa
—
6
25
6
25
2.48
1.26
1.5
1.2
—
—
—
0
0
22
143
1.68
1.24
1.3
1.2
27.6
29.0
iu/ml
—
8
50
33
238
1.57
1.24
7.4
2.8
—
—
—
0
0
48
377
1.51
1.23
27.2
9.9
0.0
0.0
e9/l
0.00
40
316
10
50
2.11
1.21
1.0
1.3
—
—
—
0
0
5
20
2.57
1.16
1.2
1.2
—
—
—
0
0
11
59
1.97
1.12
1.4
1.2
—
—
—
0
0
7
32
2.27
1.10
1.9
1.8
—
—
—
0
0
20
287
0.62
1.07
2.4
2.9
—
—
—
0
0
0
32
0.00
0.97
0.0
1.8
—
—
—
0
0
42
336
1.42
0.93
5.5
3.4
17.8
50.9
ng/l
1.68
36
222
19
129
1.58
0.91
1.3
1.3
68.3
8.9
u/ml
—
6
52
8
42
1.98
0.91
2.5
2.3
—
—
—
0
0
8
42
1.98
0.91
3.0
4.5
—
—
—
0
0
12
73
1.73
0.86
2.0
2.0
10.1
14.3
nmol/l
0.90
12
68
11
66
1.75
0.82
1.1
1.1
—
—
—
0
0
14
201
0.65
0.73
2.2
2.9
0.9
0.8
ug/l
—
9
135
17
120
1.50
0.70
1.2
1.3
—
—
—
0
0
10
62
1.68
0.68
9.9
3.8
1.2
1.2
mmol/l
—
10
55
6
35
1.76
0.59
2.0
2.5
—
—
—
0
0
12
85
1.47
0.49
1.5
1.9
—
—
—
0
0
8
58
1.41
0.43
5.9
2.4
—
—
—
0
0
29
245
1.25
0.41
5.8
4.3
18.4
8.8
mg/mmol
0.64
21
161
27
229
1.24
0.37
4.6
3.8
0.0
0.0
estimate
—
8
77
27
231
1.23
0.34
5.3
3.4
119.0
55.9
mg/l
0.63
20
157
28
248
1.18
0.25
5.0
4.0
—
—
—
0
0
79
758
1.18
0.24
63.8
13.9
37.9
40.6
%
1.79
57
551
0
10
0.00
0.21
0.0
4.6
—
2.0
—
0
10
12
102
1.20
0.16
1.3
1.2
—
—
—
0
0
88
865
1.11
0.09
45.5
13.2
—
—
—
0
0
8
75
1.07
0.07
5.6
3.1
—
—
—
0
0
22
230
0.94
0.04
3.6
3.1
—
—
—
0
0
80
790
1.05
0.04
6.3
4.6
6.3
6.0
mmol/l
0.67
75
719
75
741
1.04
0.03
5.6
4.4
1.7
1.9
mu/l
0.84
69
659
58
571
1.04
0.02
7.1
3.8
—
—
—
0
0
84
838
1.01
0.00
62.0
13.3
28.2
24.2
mg/l
0.68
79
646
82
817
1.02
0.00
5.0
4.9
2.6
2.7
mmol/l
0.58
76
752
80
805
0.97
0.00
4.6
4.3
1.3
1.5
mmol/l
1.85
75
738
10
96
1.05
0.00
1.5
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
11.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
7
79
0.88
0.00
1.9
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
12.1
—
0
7
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
53
0.94
0.00
1.8
1.1
—
33.9
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
15.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MYSOSIS_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_MYSOSIS_NOS 4.838 [2.52, 9.31] < 0.001
Birth year 0.991 [0.98, 1.0] 0.043

During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 207 females with AB1_MYSOSIS_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_MYSOSIS_NOS 4.742 [2.8, 8.04] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 240 males with AB1_MYSOSIS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MYSOSIS_NOS.

N-year risk Females Males
1 0.397% 1.023%
5 2.369% 4.884%
10 6.124% 12.269%
15 11.84% 22.656%
20 19.31% 36.018%

Relationships between endpoints

↥

Index endpoint: AB1_MYSOSIS_NOS – Other mycoses, not elsewhere classified/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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