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Carcinoma in situ of skin of eyelid, including canthus

CD2_INSITU_SKIN_EYELID

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.1&
  • Hospital discharge: ICD-9 2321
  • Cause of death: ICD-10 D04.1&
  • Cause of death: ICD-9 2321

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis palpebrae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 65 28 37
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 75.37 75.82 75.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
58
Matched controls
577
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.1
ICD-10 Finland
Carcinoma in situ: Skin of eyelid, including canthus
+∞
80.4
57
*
CBA10
NOMESCO Finland
Biopsy of eyelid
54.6
11.5
13
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
24.6
11.0
15
8
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
133.1
10.8
11
*
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
133.1
10.8
11
*
L57.0
ICD-10 Finland
Actinic keratosis
7.6
10.2
27
59
TQW99
NOMESCO Finland
Other minor procedure on skin
12.5
10.0
18
20
CBB30
NOMESCO Finland
Excision of lesion of eyelid
37.0
9.8
12
*
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
19.0
7.6
11
7
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.2
6.8
19
42
C44.12
ICD-10 Finland
Spinocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
6.4
6
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.7
6.1
18
42

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
186
6.04
10.93
4.1
2.2
—
—
—
0
0
22
58
5.22
8.36
1.9
1.3
—
—
—
0
0
10
20
5.73
4.95
1.0
1.3
—
—
—
0
0
34
173
3.02
4.60
10.3
5.1
—
—
—
0
0
33
174
2.82
4.06
5.9
4.1
—
—
—
0
0
42
252
2.88
4.03
10.5
5.4
2.2
1.7
e9/l
0.34
37
229
41
247
2.79
3.84
10.7
5.3
0.6
0.6
e9/l
0.10
36
220
41
247
2.79
3.84
10.7
5.3
0.0
0.0
e9/l
0.06
36
222
14
48
3.44
3.56
1.1
1.2
—
—
—
0
0
41
256
2.63
3.44
11.0
5.5
0.2
0.2
e9/l
0.08
35
229
38
233
2.52
3.25
2.5
2.1
89.1
90.4
pmol/l
0.07
24
110
13
45
3.36
3.24
5.3
7.3
—
—
—
0
0
13
48
3.14
2.92
5.4
4.1
—
—
—
0
0
50
361
2.67
2.85
5.3
4.7
20.2
15.2
mm/h
0.79
44
326
39
254
2.34
2.77
8.9
5.8
1.2
1.2
mmol/l
0.16
33
222
57
456
3.03
2.66
31.4
18.3
35.6
23.6
mg/l
1.13
50
384
48
349
2.44
2.55
6.8
5.8
—
435.7
—
0
12
10
34
3.29
2.54
3.0
6.3
23.9
25.1
mmol/l
—
10
29
9
28
3.56
2.41
1.3
2.2
1.3
1.5
g/l
—
9
22
58
475
3.05
2.39
33.3
21.4
101.7
86.5
umol/l
0.74
58
475
5
9
5.91
2.25
1.2
1.1
—
—
—
0
0
58
482
2.88
2.22
32.9
21.0
138.9
139.6
mmol/l
0.87
58
465
58
484
2.84
2.21
33.8
20.9
4.0
4.0
mmol/l
0.21
58
466
9
31
3.20
2.17
3.1
5.4
24.6
25.1
mmol/l
—
9
31
30
191
2.06
2.09
2.7
3.5
2.4
2.3
mmol/l
0.43
25
158
7
21
3.60
2.03
3.6
3.6
—
—
—
0
0
26
159
2.06
2.00
3.2
2.1
—
—
—
0
0
54
434
2.44
1.97
5.6
7.4
39.5
41.7
mmol/mol
0.85
48
396
16
83
2.23
1.84
11.7
5.1
1.1
1.0
mmol/l
0.37
16
68
51
408
2.16
1.76
4.7
4.5
1.1
1.2
mmol/l
0.36
45
349
53
431
2.24
1.74
5.2
4.9
4.1
4.3
mmol/l
0.86
47
378
7
26
2.89
1.63
6.3
3.4
—
—
—
0
0
8
33
2.62
1.60
3.4
7.3
93.7
92.4
%
—
8
33
24
153
1.90
1.59
6.4
3.3
—
—
—
0
0
54
449
2.20
1.57
5.8
5.6
2.3
2.5
mmol/l
0.79
48
388
22
137
1.92
1.56
3.2
3.1
394.7
2448.1
umol/l
0.48
16
106
31
218
1.81
1.50
14.3
11.3
0.0
0.0
e9/l
0.71
25
185
11
53
2.29
1.48
2.7
2.0
334.5
227.8
ng/l
0.29
11
44
23
151
1.81
1.37
3.2
2.8
32.3
78.7
mg/l
0.84
18
91
47
383
1.82
1.31
29.2
19.1
38.0
38.6
%
0.13
28
233
11
56
2.16
1.31
1.5
1.5
—
—
—
0
0
24
162
1.76
1.30
6.5
3.3
0.1
0.3
e6/l
1.04
19
125
25
171
1.75
1.29
4.9
5.0
—
—
—
0
0
51
427
1.90
1.29
5.3
5.0
1.4
1.4
mmol/l
0.36
45
370
6
25
2.54
1.27
2.3
1.5
0.6
1.3
g/l
—
6
20
10
50
2.18
1.24
3.2
1.6
—
—
—
0
0
28
202
1.68
1.18
3.8
3.5
—
—
—
0
0
24
166
1.71
1.18
3.5
3.7
5.8
11.3
mg/mmol
0.71
19
101
10
52
2.09
1.13
3.0
7.0
115.6
121.8
g/l
—
10
52
13
75
1.92
1.13
2.1
1.6
—
—
—
0
0
18
118
1.73
1.05
3.3
4.1
—
—
—
0
0
5
22
2.37
1.05
1.4
1.2
—
—
—
0
0
28
207
1.62
1.05
7.1
4.3
46.3
86.3
e6/l
0.50
20
155
49
417
1.71
1.03
4.6
4.9
2.0
2.0
mu/l
0.06
44
358
6
27
2.34
0.96
2.8
2.5
—
—
—
0
0
43
361
1.56
0.89
8.3
5.0
—
—
—
0
0
8
47
1.80
0.84
1.1
1.3
—
—
—
0
0
23
171
1.53
0.81
2.4
2.3
55.3
61.2
u/l
0.29
18
159
0
24
0.00
0.81
0.0
5.3
—
—
—
0
0
13
85
1.66
0.76
4.7
2.5
19.8
21.8
%
0.26
13
71
13
86
1.64
0.73
4.5
2.4
2.2
2.2
g/l
0.02
13
73
5
28
1.85
0.67
1.4
1.2
—
—
—
0
0
52
470
1.53
0.63
27.8
16.9
—
—
—
0
0
11
73
1.61
0.61
1.1
1.3
—
—
—
0
0
6
34
1.84
0.60
2.8
2.9
—
—
—
0
0
24
190
1.42
0.60
6.6
3.6
8.8
353.6
e6/l
0.52
17
148
9
59
1.61
0.58
4.9
4.1
-0.5
2.3
mmol/l
—
9
44
9
62
1.52
0.56
4.9
3.9
—
—
—
0
0
27
223
1.36
0.52
11.8
10.4
1.3
1.3
inr
—
5
76
7
46
1.58
0.50
1.1
2.4
—
—
—
0
0
49
446
1.40
0.49
5.9
5.4
6.0
6.1
mmol/l
0.15
43
388
13
96
1.44
0.46
7.7
5.4
—
—
—
0
0
18
144
1.35
0.41
8.4
7.0
—
—
—
0
0
5
35
1.46
0.40
4.0
1.4
—
—
—
0
0
5
35
1.46
0.40
2.4
1.4
—
—
—
0
0
6
42
1.47
0.37
2.5
3.9
—
—
—
0
0
39
354
1.25
0.33
36.3
23.9
329.6
330.4
g/l
0.21
39
349
12
150
0.75
0.31
5.3
4.7
—
—
—
0
0
27
238
1.23
0.29
6.1
4.7
32.3
34.4
ng/l
0.11
21
192
10
127
0.75
0.29
3.4
4.0
—
—
—
0
0
5
38
1.34
0.24
1.6
1.5
—
—
—
0
0
5
40
1.27
0.23
1.6
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
11
90
1.27
0.21
2.6
1.8
29.6
30.0
s
0.12
11
83
10
82
1.26
0.18
2.2
3.0
1.6
1.7
%
—
10
70
8
77
1.04
0.07
1.0
1.2
—
49.0
iu/ml
—
0
25
35
338
1.08
0.06
5.3
4.5
—
—
—
0
0
11
106
1.05
0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
428.7
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
37.5
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
6.2
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
57.2
—
0
5
0
5
0.00
0.00
0.0
1.8
—
15.9
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
30.4
—
0
5
5
49
1.02
0.00
2.6
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
6.0
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_EYELID – Carcinoma in situ of skin of eyelid, including canthus

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).