ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
108 |
4. Check minimum number of eventsNone |
108 |
5. Include endpointsNone |
108 |
6. Filter based on genotype QC (FinnGen only) |
108 |
Control definitions (FinnGen only)
- Control exclude
- K11_ENERCOLNONINF
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K51
- Name in latin
- Pseudopolyposis coli
Similar endpoints
↥List of similar endpoints to
Pseudopolyposis of colon
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 578 | 213 | 362 |
| Only index persons | 556 | 208 | 348 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.37 | 48.91 | 49.79 |
| Only index persons | 49.04 | 48.02 | 49.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 108 | 50 | 58 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 48.67 | 42.83 | 53.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 108
- Matched controls
- 1080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
155.8
108
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
128.0
96
*
A07EC02
ATC
mesalazine; oral, rectal
1587.9
115.8
93
*
K51.5
ICD-10 Finland
Left sided colitis
+∞
105.0
83
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
89.4
73
*
UJF30
NOMESCO Finland
Ileoscopy through colon
35.5
75.1
57
33
UJF32
NOMESCO Finland
Coloscopy
33.6
71.1
88
125
L04AX01
ATC
azathioprine; systemic
246.3
67.0
63
6
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
58.8
51
*
A07EA02
ATC
hydrocortisone; rectal
930.4
57.1
51
*
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
40.1
36
*
A07EA06
ATC
budesonide; oral, local oral
156.3
39.9
40
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
15.3
37.8
40
40
A07EC01
ATC
sulfasalazine; oral, rectal
14.1
33.1
36
37
H02AB07
ATC
prednisone; oral
11.2
33.1
46
67
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
30.7
28
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
27.2
25
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
25.0
23
*
K51
ICD-10 Finland
Ulcerative colitis
+∞
23.8
22
*
H02AB06
ATC
prednisolone; systemic
8.4
22.5
85
329
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
21.6
20
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
20.5
19
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.5
17.7
57
182
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
17.1
16
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
17.1
16
*
L01BB02
ATC
mercaptopurine; oral
+∞
16.0
15
*
D94
ICPC
Chronic enteritis/ulcerative colitis
185.8
15.9
16
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
+∞
13.8
13
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
13.8
13
*
A07EA01
ATC
prednisolone; oral, rectal
+∞
13.8
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.6
13.7
49
164
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
12.7
12
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
12.7
12
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
11.7
11
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
28.7
11.5
15
6
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
14.1
11.4
19
16
WX002
NOMESCO Finland
Sedation and analgesia
4.5
11.0
34
100
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
11.0
65
302
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
10.1
27
70
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
9.8
37
125
J01MA02
ATC
ciprofloxacin; systemic
3.6
9.7
59
273
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
9.5
9
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
20.8
9.2
13
7
P01AB01
ATC
metronidazole; oral, rectal
3.4
9.0
61
299
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.1
8.9
21
49
A07EC03
ATC
olsalazine; oral
+∞
8.4
8
*
A06AC01
ATC
ispaghula (psylla seeds); oral
3.6
8.2
36
133
L04AB02
ATC
infliximab; parenteral
85.7
7.5
8
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
7.4
7
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
7.4
7
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
10.4
7.0
13
14
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
74.0
6.5
7
*
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
74.0
6.5
7
*
Z93.2
ICD-10 Finland
Ileostomy status
+∞
6.3
6
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
+∞
6.3
6
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.1
6.2
19
54
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
36
10.65
22.93
1.9
1.7
—
—
—
0
0
51
166
4.93
15.04
2.7
2.0
2.89
3.37
mg/l
0.69
41
144
86
499
4.55
10.16
15.4
9.4
4.37
4.13
e9/l
0.43
81
437
63
332
3.15
7.91
6.6
5.3
1.19
1.22
mmol/l
1.40
57
305
63
344
3.00
7.23
11.1
10.8
1.10
1.22
inr
0.67
21
106
55
289
2.84
6.63
5.3
2.8
33.16
31.97
u/l
0.14
50
269
13
16
9.06
6.55
1.5
1.6
—
—
—
0
0
64
371
2.78
6.28
7.4
6.5
1.20
1.22
mmol/l
0.89
52
320
27
100
3.27
5.98
2.3
2.4
20.30
25.37
%
1.33
20
89
10
11
9.88
5.41
4.1
2.8
3.15
3.82
e9/l
—
10
11
10
12
9.05
5.18
4.2
3.0
52.30
55.00
%
—
10
12
8
7
12.21
4.87
1.0
1.0
—
—
—
0
0
6
6
10.48
3.54
2.5
1.0
—
—
titre
—
0
0
13
42
3.38
3.50
4.5
2.1
91.03
176.40
ng/l
0.53
13
36
7
10
7.39
3.42
1.0
1.1
—
—
—
0
0
22
99
2.53
3.34
10.5
6.3
103.45
104.06
mmol/l
0.20
22
99
48
301
2.07
3.32
1.8
1.9
92.59
95.62
pmol/l
0.18
29
153
7
12
6.15
3.07
1.0
1.6
—
—
—
0
0
12
37
3.52
3.05
1.2
1.6
—
—
—
0
0
8
17
4.99
2.98
1.8
1.2
—
—
—
0
0
18
78
2.57
2.94
11.2
7.7
4.73
5.18
kpa
0.78
18
72
6
9
6.98
2.90
1.3
2.0
—
—
—
0
0
5
6
8.66
2.77
1.6
1.3
—
—
—
0
0
5
6
8.66
2.77
1.6
1.3
—
—
—
0
0
6
10
6.28
2.73
1.3
1.9
—
—
—
0
0
6
10
6.28
2.73
1.3
1.9
—
—
—
0
0
6
10
6.28
2.73
1.3
1.9
—
—
—
0
0
6
10
6.28
2.73
1.3
1.9
—
—
—
0
0
6
10
6.28
2.73
1.3
1.9
—
—
—
0
0
27
147
2.12
2.64
6.2
2.8
642.06
149.98
ng/l
0.49
16
99
17
77
2.43
2.53
11.8
7.7
2.76
0.92
mmol/l
—
10
61
31
184
1.96
2.39
1.5
1.5
19.79
20.65
nmol/l
0.12
26
150
6
14
4.47
2.18
1.3
1.4
—
—
—
0
0
29
174
1.91
2.15
1.5
1.7
0.75
0.83
mg/l
0.14
23
142
5
10
5.18
2.09
1.6
1.5
—
—
—
0
0
5
10
5.18
2.09
1.6
1.5
—
—
—
0
0
103
937
3.14
2.07
33.0
13.5
73.29
76.91
umol/l
1.02
103
937
6
15
4.17
2.07
1.5
1.5
—
—
—
0
0
53
390
1.70
1.97
3.0
2.4
—
—
—
0
0
6
16
3.90
1.96
1.5
1.5
—
—
—
0
0
6
16
3.90
1.96
1.3
1.4
—
—
—
0
0
31
199
1.78
1.84
1.4
1.4
0.77
1.19
u/ml
—
6
63
32
208
1.77
1.83
2.0
2.0
—
—
—
0
0
5
14
3.69
1.63
1.4
1.4
—
—
—
0
0
18
105
1.86
1.44
4.1
6.0
0.98
0.99
mmol/l
0.04
18
96
6
23
2.70
1.38
1.2
1.3
—
—
—
0
0
37
270
1.56
1.32
3.2
3.0
2.33
2.35
mmol/l
0.71
32
241
6
25
2.48
1.26
1.2
1.1
—
5.30
—
0
7
5
19
2.71
1.23
1.2
1.3
—
—
—
0
0
17
103
1.77
1.21
3.3
4.1
32.70
30.48
%
—
10
67
0
33
0.00
1.18
0.0
1.5
—
—
—
0
0
0
35
0.00
1.17
0.0
1.8
—
4.76
—
0
26
5
20
2.57
1.16
1.8
1.1
—
—
—
0
0
39
299
1.48
1.09
3.9
3.4
45.23
33.88
ng/l
0.22
25
201
7
35
2.07
1.02
1.1
1.8
—
—
—
0
0
87
785
1.56
1.01
4.7
4.5
1.58
1.89
mu/l
1.94
76
724
17
250
0.62
0.99
3.9
4.1
16.02
22.17
%
—
9
103
11
62
1.86
0.98
3.8
3.3
55.00
64.64
ml/min/173m2
—
5
28
0
31
0.00
0.98
0.0
1.4
—
—
—
0
0
0
31
0.00
0.98
0.0
1.3
—
—
—
0
0
0
31
0.00
0.98
0.0
1.4
—
—
—
0
0
74
649
1.45
0.97
3.9
4.0
14.99
14.69
pmol/l
0.42
66
597
30
229
1.43
0.84
6.0
3.3
0.00
0.00
estimate
—
10
86
84
763
1.45
0.83
32.8
14.0
14.60
14.48
%
0.08
84
754
8
48
1.72
0.80
1.1
3.4
4.84
4.56
pmol/l
—
8
40
6
33
1.86
0.80
1.2
2.0
—
—
—
0
0
5
26
1.97
0.71
3.0
1.3
—
—
—
0
0
5
27
1.89
0.69
1.2
1.8
—
—
—
0
0
5
29
1.76
0.64
1.4
1.0
—
—
—
0
0
5
29
1.76
0.64
1.4
1.0
—
—
—
0
0
87
819
1.32
0.49
4.0
4.1
5.79
5.85
mmol/l
0.20
77
756
7
47
1.52
0.48
9.9
9.9
0.59
0.71
%
—
7
47
7
47
1.52
0.48
9.9
9.9
0.94
1.36
%
—
7
47
13
95
1.42
0.46
3.5
2.3
11.62
14.80
nmol/l
0.67
13
90
7
50
1.43
0.46
1.0
1.3
160.43
311.77
mu/l
—
7
44
5
33
1.54
0.42
2.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
9
68
1.35
0.39
4.8
2.1
16.53
5.53
ug/l
—
9
60
38
335
1.21
0.36
5.7
3.2
—
—
—
0
0
15
119
1.30
0.34
3.6
1.6
—
—
—
0
0
8
109
0.71
0.30
1.4
1.7
—
—
—
0
0
84
805
1.20
0.27
5.5
5.1
39.05
39.16
mmol/mol
0.04
79
763
9
75
1.22
0.26
4.9
1.5
—
—
—
0
0
5
37
1.37
0.24
3.0
1.3
—
—
—
0
0
20
173
1.19
0.23
1.5
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
87
843
1.16
0.20
3.9
3.7
1.33
1.30
mmol/l
0.14
80
779
6
52
1.16
0.19
1.3
1.2
—
—
—
0
0
15
129
1.19
0.18
1.6
1.5
—
—
—
0
0
66
632
1.11
0.17
3.4
3.4
—
—
—
0
0
9
77
1.18
0.16
5.0
1.5
—
—
—
0
0
30
277
1.11
0.15
4.3
2.8
—
—
—
0
0
16
142
1.15
0.13
1.7
2.7
2.44
2.43
mmol/l
0.03
16
126
84
820
1.11
0.12
24.7
11.0
89.38
86.04
ml/min/173m2
0.74
72
668
90
883
1.12
0.11
4.6
4.2
4.62
4.68
mmol/l
0.19
85
825
24
223
1.10
0.10
5.4
3.9
8.02
9.93
mg/mmol
0.10
17
145
5
43
1.17
0.10
2.6
6.1
24.96
25.11
mmol/l
—
5
43
44
422
1.07
0.09
5.3
3.3
0.00
0.00
estimate
-0.00
11
80
10
88
1.15
0.08
4.7
3.0
—
—
—
0
0
7
63
1.12
0.08
2.1
1.9
—
—
—
0
0
41
421
0.96
0.04
5.6
3.2
0.00
0.01
estimate
0.49
12
90
13
121
1.08
0.04
2.1
2.0
—
—
—
0
0
90
891
1.06
0.03
4.8
4.6
2.76
2.82
mmol/l
0.20
83
828
41
418
0.97
0.02
6.7
4.5
0.00
0.00
estimate
-0.00
11
87
15
147
1.02
0.00
1.1
1.3
1.21
7.78
u/ml
—
7
64
14
136
1.03
0.00
2.1
2.2
—
—
—
0
0
10
105
0.95
0.00
16.5
6.8
—
—
—
0
0
88
879
1.01
0.00
4.4
4.1
1.41
1.42
mmol/l
0.04
82
818
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
2.4
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint COLONPSEUDOP and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COLONPSEUDOP | 1.439 [1.04, 2.0] | 0.029 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 325 males with COLONPSEUDOP died.
Mortality risk
Mortality risk for people of age
years, who have COLONPSEUDOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.245% |
| 5 | No data | 1.514% |
| 10 | No data | 3.885% |
| 15 | No data | 7.248% |
| 20 | No data | 12.735% |
Relationships between endpoints
↥Index endpoint: COLONPSEUDOP – Pseudopolyposis of colon
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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