eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other retinal disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
H7_RETINODISINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
72 |
4. Check minimum number of eventsNone |
72 |
5. Include endpointsNone |
72 |
6. Filter based on genotype QC (FinnGen only) |
72 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other retinal disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 264 | 305 |
| Only index persons | 475 | 225 | 250 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 73.40 | 75.61 | 71.43 |
| Only index persons | 71.89 | 74.19 | 69.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 72 | 20 | 52 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 70.61 | 68.00 | 71.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 65
- Matched controls
- 648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H36.8*I70.8
ICD-10 Finland
Atherosclerotic retinopathy
+∞
66.5
52
*
CKC12
NOMESCO Finland
Photocoagulation of retina
131.4
18.7
19
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
12.0
16.0
33
51
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
37.4
15.3
19
7
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
21.5
13.7
20
13
XCK10
NOMESCO Finland
Photography of fundus of eye
12.0
13.0
25
32
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
10.7
10
*
H36.8
ICD-10 Finland
Other retinal disorders in diseases classified elsewhere
+∞
10.7
10
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.2
10.3
21
29
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
26.5
9.8
13
6
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
13.5
8.9
15
14
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
102.8
8.6
9
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
26.0
8.3
11
5
B01AC04
ATC
clopidogrel; oral
5.7
8.3
27
72
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.2
8.2
24
56
C08CA01
ATC
amlodipine; oral
4.7
8.2
39
157
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.7
7.7
24
60
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
14.4
7.4
12
10
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
+∞
7.4
7
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
6.8
6.8
17
32
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.1
6.7
36
152
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
11.0
6.6
12
13
XF400
NOMESCO Finland
ECG with 12 standard connections
4.7
6.5
24
72
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
6.3
6
*
H3601, E113
ICD-10 Finland
NA
+∞
6.3
6
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
6.3
6
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
6.5
6.2
16
31
ZXA00
NOMESCO Finland
Right side
4.1
6.2
30
112
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.3
6.1
13
19
ZXA10
NOMESCO Finland
Bilateral
4.7
6.1
22
64
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
120
3.37
5.65
4.9
2.3
—
—
—
0
0
9
9
11.21
5.19
3.8
3.3
174.8
243.6
%
—
9
9
16
49
3.91
4.80
17.8
5.1
1.2
2.2
mmol/l
0.54
16
34
18
69
3.14
3.82
20.0
7.4
1.3
1.0
mmol/l
1.06
18
64
8
12
7.34
3.78
4.4
3.0
3.2
4.1
g/l
—
8
12
35
195
2.55
3.67
2.4
1.9
91.5
91.0
pmol/l
0.02
17
106
41
247
2.53
3.63
19.5
6.3
1.2
1.2
mmol/l
0.85
35
211
7
12
6.33
3.10
4.4
2.8
91.6
78.0
%
—
7
12
16
67
2.78
2.88
18.1
7.7
103.8
105.4
mmol/l
0.57
16
67
15
62
2.79
2.76
16.9
7.9
5.4
4.9
kpa
1.27
15
57
35
220
2.15
2.56
10.5
3.8
—
—
—
0
0
7
16
4.72
2.54
2.0
1.8
—
—
—
0
0
6
12
5.34
2.45
1.3
1.8
—
—
—
0
0
6
12
5.34
2.45
1.3
1.8
—
—
—
0
0
19
94
2.39
2.44
6.1
2.6
0.4
0.7
e6/l
—
10
54
10
36
3.06
2.31
23.7
10.2
0.6
0.7
%
—
10
36
10
37
2.98
2.20
23.7
9.3
2.3
1.6
%
—
10
37
18
91
2.30
2.19
6.4
2.7
0.3
0.6
e6/l
—
9
52
10
38
2.89
2.11
21.0
7.1
24.7
24.4
mmol/l
—
10
38
8
29
2.97
1.85
1.6
1.2
—
—
—
0
0
5
15
3.50
1.55
3.4
1.1
—
—
—
0
0
8
35
2.44
1.32
2.1
1.5
—
—
—
0
0
11
188
0.51
1.22
7.4
4.1
—
—
—
0
0
12
68
1.92
1.08
2.2
1.6
—
—
—
0
0
16
101
1.75
1.04
2.1
1.8
—
—
—
0
0
0
29
0.00
1.00
0.0
1.1
—
—
—
0
0
23
165
1.58
0.94
6.2
3.8
59.1
12.6
mg/mmol
0.67
14
106
12
72
1.80
0.92
2.2
1.7
—
—
—
0
0
38
311
1.47
0.82
12.6
4.8
7.7
6.8
mmol/l
0.94
38
290
9
53
1.80
0.79
2.3
3.9
3.1
79.8
ug/l
—
9
48
8
127
0.58
0.72
2.3
1.5
1.1
1.3
mmol/l
—
8
107
26
202
1.45
0.72
6.4
3.4
—
—
—
0
0
7
42
1.74
0.71
2.0
1.5
—
—
—
0
0
40
342
1.38
0.62
3.0
3.4
14.4
14.9
pmol/l
0.50
33
301
9
60
1.57
0.57
10.3
11.5
—
—
—
0
0
50
448
1.38
0.55
31.0
14.9
70.5
75.6
ml/min/173m2
0.63
44
371
0
18
0.00
0.40
0.0
1.5
—
45.7
—
0
18
23
271
0.78
0.39
3.3
2.7
—
—
—
0
0
19
226
0.78
0.34
4.7
4.4
19.2
21.9
%
—
6
117
13
103
1.32
0.31
1.9
1.6
643.9
1186.0
nmol/l
—
8
77
47
438
1.21
0.27
4.3
4.1
1.8
2.0
mu/l
0.78
41
382
53
502
1.21
0.24
41.6
15.1
28.4
26.9
mg/l
0.15
47
410
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
27
297
0.85
0.21
4.2
5.1
38.5
2.3
ug/l
0.47
21
262
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
58
1.23
0.19
8.1
3.5
—
—
—
0
0
47
445
1.16
0.19
5.0
4.2
1.4
1.3
mmol/l
0.25
41
402
15
166
0.88
0.11
3.3
3.1
0.3
0.7
ug/l
—
9
113
5
62
0.79
0.08
2.4
1.5
—
—
—
0
0
17
157
1.11
0.08
5.4
2.7
46.6
34.0
u/l
0.41
17
151
50
487
1.09
0.07
6.8
5.1
2.2
2.6
mmol/l
3.66
44
434
46
472
0.93
0.06
6.3
5.0
7.2
6.2
mmol/l
1.59
37
419
47
462
1.05
0.02
5.7
4.6
1.2
1.4
mmol/l
1.96
41
415
52
513
1.05
0.01
42.7
18.4
139.0
139.6
mmol/l
0.61
52
496
47
464
1.04
0.00
5.6
4.7
3.8
4.4
mmol/l
4.29
42
421
52
515
1.03
0.00
46.7
18.5
4.1
4.0
mmol/l
0.98
52
498
0
9
0.00
0.00
0.0
1.4
—
44.9
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
0
9
0.00
0.00
0.0
5.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
52
520
1.00
0.00
35.9
18.4
126.9
87.1
umol/l
1.22
52
520
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINODISINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 2.022 [1.43, 2.87] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.309 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 224 females with H7_RETINODISINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 3.116 [2.09, 4.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 276 males with H7_RETINODISINOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINODISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | 0.653% |
| 5 | 1.355% | 3.505% |
| 10 | 3.207% | 8.552% |
| 15 | 5.726% | 16.384% |
| 20 | 10.189% | 26.337% |
Relationships between endpoints
↥Index endpoint: H7_RETINODISINOTH – Other retinal disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data