eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other retinal disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
H7_RETINODISINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
79 |
4. Check minimum number of eventsNone |
79 |
5. Include endpointsNone |
79 |
6. Filter based on genotype QC (FinnGen only) |
75 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other retinal disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 264 | 305 |
| Only index persons | 475 | 225 | 250 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 73.40 | 75.61 | 71.43 |
| Only index persons | 71.89 | 74.19 | 69.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 75 | 23 | 52 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 71.23 | 70.43 | 71.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H36.8*I70.8
ICD-10 Finland
Atherosclerotic retinopathy
+∞
87.5
67
*
XCK10
NOMESCO Finland
Photography of fundus of eye
14.0
26.5
30
33
CKC12
NOMESCO Finland
Photocoagulation of retina
+∞
25.4
23
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
10.5
24.6
39
67
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
39.7
20.3
25
9
Z3229
NOMESCO Finland
Other healthcare associate professional
10.6
20.0
27
37
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
14.4
14.0
24
23
Z2221
NOMESCO Finland
Medical doctor
5.7
13.4
40
121
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.7
13.2
24
26
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
12.8
12
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
6.9
11.9
22
42
I25.1
ICD-10 Finland
Atherosclerotic heart disease
5.0
11.5
45
166
Z3231
NOMESCO Finland
Registered nurse
5.0
11.5
42
147
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
21.8
11.3
16
9
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
126.1
10.7
11
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
15.1
10.5
17
14
B01AC04
ATC
clopidogrel; oral
4.7
10.4
37
125
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
16.7
9.1
14
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
8.8
28
85
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.4
8.8
31
102
WX002
NOMESCO Finland
Sedation and analgesia
4.6
8.6
26
76
H36.8
ICD-10 Finland
Other retinal disorders in diseases classified elsewhere
+∞
8.5
8
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
13.9
8.5
14
12
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
37.6
8.3
10
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
11.3
8.2
15
16
A10AC01
ATC
insulin (human); parenteral
7.7
8.2
19
31
ZXA00
NOMESCO Finland
Right side
3.9
7.9
35
134
R4110
NOMESCO Finland
Physiotherapy
3.9
7.9
35
134
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
13.9
7.9
13
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
7.8
23
65
XF400
NOMESCO Finland
ECG with 12 standard connections
4.1
7.6
28
94
H34.8
ICD-10 Finland
Other retinal vascular occlusions
88.0
7.6
8
*
H3601, E113,
ICD-10 Finland
+∞
7.4
7
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
7.4
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.5
6.9
43
203
NHQ40
NOMESCO Finland
Amputation of toe
25.0
6.8
9
*
ZXA10
NOMESCO Finland
Bilateral
3.8
6.7
26
90
ZXE00
NOMESCO Finland
One hour or less
3.4
6.6
42
199
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
75.7
6.5
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.3
6.5
40
186
A10AA02, ,
ATC
20.0
6.4
9
5
A10AB05
ATC
insulin aspart; parenteral
6.6
6.4
16
29
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.9
6.4
23
75
A10AE04
ATC
insulin glargine; parenteral
4.6
6.4
17
44
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
29.3
6.4
8
*
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
6.3
6
*
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
6.3
6
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
6.3
6
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.4
6.3
11
11
Z3226
NOMESCO Finland
Physiotherapist
3.7
6.2
25
88
C10AA01
ATC
simvastatin; oral
3.3
6.1
52
290
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
50
4.69
7.02
21.6
5.0
1.61
2.45
mmol/l
0.48
19
36
33
136
3.45
6.49
5.1
2.3
—
—
—
0
0
10
9
12.49
5.98
3.5
3.3
194.40
243.56
%
—
10
9
42
225
2.85
4.98
2.5
1.9
92.42
90.17
pmol/l
0.11
19
119
9
12
8.29
4.49
4.0
3.0
3.43
4.06
g/l
—
9
12
19
69
3.31
4.40
21.0
7.7
103.68
105.26
mmol/l
0.67
19
69
47
283
2.63
4.22
21.3
6.0
1.19
1.21
mmol/l
1.17
41
239
20
77
3.14
4.20
22.3
6.8
1.27
1.04
mmol/l
1.29
20
71
10
20
5.56
3.83
2.3
2.4
341.90
349.68
ug/l
—
10
20
8
12
7.27
3.77
4.0
2.8
91.75
78.00
%
—
8
12
13
40
3.68
3.33
21.1
6.8
25.28
24.37
mmol/l
0.50
13
40
7
12
6.28
3.09
1.3
1.8
—
—
—
0
0
7
12
6.28
3.09
1.3
1.8
—
—
—
0
0
16
66
2.79
2.93
16.3
7.8
5.42
4.84
kpa
1.49
16
61
39
248
2.13
2.73
6.3
2.5
—
—
—
0
0
20
99
2.37
2.54
6.2
2.8
0.45
0.68
e6/l
0.60
11
58
11
38
3.19
2.53
22.2
9.0
2.11
1.37
%
0.35
11
38
11
38
3.19
2.53
22.2
9.7
0.65
0.72
%
0.29
11
38
7
17
4.41
2.42
2.0
1.8
—
—
—
0
0
19
94
2.34
2.41
6.4
2.9
2.40
0.80
e6/l
—
10
55
5
8
6.58
2.40
1.0
1.1
—
—
—
0
0
43
298
1.97
2.26
20.0
14.7
1.21
1.36
inr
—
7
84
10
37
2.94
2.16
2.0
1.5
—
—
—
0
0
9
33
2.94
2.00
1.6
1.2
—
—
—
0
0
5
11
4.77
1.97
1.0
1.4
—
—
—
0
0
28
175
1.93
1.93
5.9
3.7
52.03
11.49
mg/mmol
0.67
16
114
5
12
4.37
1.85
1.0
1.4
—
—
—
0
0
15
77
2.17
1.73
2.2
1.6
—
—
—
0
0
20
116
1.97
1.69
2.0
1.8
—
—
—
0
0
15
80
2.08
1.58
2.2
1.8
—
—
—
0
0
5
15
3.48
1.54
3.4
1.1
—
—
—
0
0
10
45
2.40
1.53
1.9
1.4
—
—
—
0
0
12
214
0.48
1.52
6.9
4.4
—
—
—
0
0
42
319
1.68
1.42
16.0
8.7
4.50
4.38
e9/l
0.09
37
273
5
19
2.74
1.23
1.4
1.1
—
—
—
0
0
6
26
2.41
1.21
16.8
2.9
1.07
1.35
%
—
6
26
43
344
1.55
1.08
14.3
4.8
7.61
6.77
mmol/l
1.15
43
320
0
30
0.00
0.99
0.0
1.1
—
—
—
0
0
8
137
0.54
0.94
2.3
1.6
1.08
1.36
mmol/l
—
8
114
29
224
1.47
0.81
6.0
3.5
—
—
—
0
0
57
501
1.49
0.81
32.8
15.0
69.24
75.96
ml/min/173m2
1.00
49
413
10
61
1.73
0.72
3.3
4.1
3.02
72.14
ug/l
—
10
56
5
28
1.84
0.67
1.6
1.9
—
—
—
0
0
45
388
1.37
0.65
3.1
3.5
14.71
14.94
pmol/l
0.19
38
339
54
493
1.30
0.45
4.6
4.3
1.71
2.00
mu/l
1.34
48
431
0
18
0.00
0.40
0.0
1.6
—
44.78
—
0
18
15
118
1.33
0.37
1.8
1.6
643.88
1211.69
nmol/l
—
8
86
21
175
1.27
0.35
4.8
2.8
42.62
33.39
u/l
0.36
21
169
59
556
1.24
0.30
42.6
15.3
29.68
26.16
mg/l
0.51
53
453
8
66
1.24
0.28
7.6
3.5
—
—
—
0
0
9
71
1.30
0.27
10.3
10.6
—
—
—
0
0
57
541
1.19
0.23
7.0
5.2
2.19
2.63
mmol/l
4.36
51
484
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
47.34
—
0
10
6
47
1.30
0.21
34.2
3.6
1.18
1.22
mmol/l
—
6
41
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
52
495
1.15
0.18
5.2
4.3
1.38
1.30
mmol/l
0.47
46
448
28
304
0.88
0.17
3.0
2.7
—
—
—
0
0
59
568
1.15
0.16
45.6
18.7
139.08
139.66
mmol/l
0.67
59
548
59
570
1.14
0.14
49.5
18.8
4.08
4.02
mmol/l
0.80
59
552
22
236
0.91
0.09
4.5
4.4
19.23
21.50
%
—
6
122
27
254
1.10
0.09
5.1
4.1
226.73
42.70
ng/l
0.65
22
180
6
72
0.82
0.08
2.2
1.4
—
—
—
0
0
59
576
1.10
0.08
38.1
18.5
126.44
85.81
umol/l
1.45
59
576
16
171
0.92
0.05
3.4
3.1
0.35
0.69
ug/l
—
10
118
30
308
0.96
0.02
4.1
5.1
33.82
2.38
ug/l
0.47
24
273
52
514
1.03
0.00
5.8
4.7
1.19
1.39
mmol/l
2.71
46
464
53
529
1.01
0.00
6.2
5.0
7.14
6.14
mmol/l
1.91
44
471
52
517
1.02
0.00
5.7
4.8
3.83
4.46
mmol/l
5.40
47
470
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINODISINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 2.022 [1.43, 2.87] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.309 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 224 females with H7_RETINODISINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 3.116 [2.09, 4.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 276 males with H7_RETINODISINOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINODISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | 0.653% |
| 5 | 1.355% | 3.505% |
| 10 | 3.207% | 8.552% |
| 15 | 5.726% | 16.384% |
| 20 | 10.189% | 26.337% |
Relationships between endpoints
↥Index endpoint: H7_RETINODISINOTH – Other retinal disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data