Other retinal disorders in diseases classified elsewhere

H7_RETINODISINOTH

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H36.8, H36.8D57.8, H36.8E75.6, H36.8I70.8 Cause of death: ICD-10 — H36.8, H36.8D57.8, H36.8E75.6, H36.8I70.8 2 out of 7 registries used, show all original rules.	72
4. Check minimum number of events None	72
5. Include endpoints None	72
6. Filter based on genotype QC (FinnGen only)	72

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_RETINODISINOTH
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H368
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H368
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other retinal disorders in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	574	264	305
Only index persons	475	225	250
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	73.40	75.61	71.43
Only index persons	71.89	74.19	69.82

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	72	20	52
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	70.61	68.00	71.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
65: Matched controls
648

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H36.8*I70.8

ICD-10 Finland

Atherosclerotic retinopathy

+∞

66.5

CKC12

NOMESCO Finland

Photocoagulation of retina

131.4

18.7

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

12.0

16.0

I65.2

ICD-10 Finland

Occlusion and stenosis of carotid artery

37.4

15.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

21.5

13.7

XCK10

NOMESCO Finland

Photography of fundus of eye

12.0

13.0

Z3229

NOMESCO Finland

Other healthcare associate professional

11.2

11.7

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

+∞

10.7

H36.8

ICD-10 Finland

Other retinal disorders in diseases classified elsewhere

+∞

10.7

XCW99

NOMESCO Finland

Other investigative procedure of eye

10.2

10.3

PAF14

NOMESCO Finland

Thrombendarterectomy of internal carotid artery

26.5

9.8

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

13.5

8.9

Z3231

NOMESCO Finland

Registered nurse

5.1

8.7

120

PAN14

NOMESCO Finland

Plastic repair of arteries internal carotid artery

102.8

8.6

I70.9

ICD-10 Finland

Generalized and unspecified atherosclerosis

26.0

8.3

B01AC04

ATC

clopidogrel; oral

5.7

8.3

Z2221

NOMESCO Finland

Medical doctor

5.0

8.3

111

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

6.2

8.2

C08CA01

ATC

amlodipine; oral

4.7

8.2

157

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

5.7

7.7

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

14.4

7.4

I70.8

ICD-10 Finland

Atherosclerosis of other arteries

+∞

7.4

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

6.8

I25.1

ICD-10 Finland

Atherosclerotic heart disease

4.1

6.7

152

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

11.0

6.6

XF400

NOMESCO Finland

ECG with 12 standard connections

4.7

6.5

H34.8

ICD-10 Finland

Other retinal vascular occlusions

+∞

6.3

H3601, E113

ICD-10 Finland

+∞

6.3

XCD20

NOMESCO Finland

Photoangiography of eye

+∞

6.3

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

6.5

6.2

ZXA00

NOMESCO Finland

Right side

4.1

6.2

112

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

8.3

6.1

ZXA10

NOMESCO Finland

Bilateral

4.7

6.1

Mortality – FinRegistry

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Association

Association between endpoint H7_RETINODISINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_RETINODISINOTH	2.022 [1.43, 2.87]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.309

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 224 females with H7_RETINODISINOTH died.

Males

Parameter	HR [95% CI]	p-value
H7_RETINODISINOTH	3.116 [2.09, 4.64]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 276 males with H7_RETINODISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINODISINOTH.

N-year risk	Females	Males
1	0.201%	0.653%
5	1.355%	3.505%
10	3.207%	8.552%
15	5.726%	16.384%
20	10.189%	26.337%

Relationships between endpoints

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Index endpoint: H7_RETINODISINOTH – Other retinal disorders in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other retinal disorders in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints