Labyrinthitis

H8_LABYRINTHITIS

labyrinthitis: Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [ https://en.wikipedia.org/wiki/Labyrinthitis NCIT:C128369 ]

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H83.0
  • Hospital discharge: ICD-9 3863
  • Hospital discharge: ICD-8 38403
  • Cause of death: ICD-10 H83.0
  • Cause of death: ICD-9 3863
  • Cause of death: ICD-8 38403

2 out of 7 registries used, show all original rules.

117

4. Check minimum number of events

None

117

5. Include endpoints

None

117

6. Filter based on genotype QC (FinnGen only)

117

Control definitions (FinnGen only)

Control exclude
H8_INNER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H83
Name in latin
Labyrinthitis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1255 675 574
Only index persons 913 513 400
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 36.37 39.34 32.62
Only index persons 37.48 39.64 34.71

-FinnGen-

Key figures

All Female Male
Number of individuals 117 80 37
Unadjusted period prevalence (%) 0.02 0.03 0.02
Median age at first event (years) 43.02 38.94 51.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
108
Matched controls
1080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.0
ICD-10 Finland
Labyrinthitis
+∞
89.4
73
*
38403
ICD-8 Finland
Other inflammatory diseases of ear, Labyrinthitis
+∞
34.2
31
*
R42
ICD-10 Finland
Dizziness and giddiness
4.7
10.6
42
129
H81.3
ICD-10 Finland
Other peripheral vertigo
97.3
8.5
9
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
6.2
7.2
19
36
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
9.7
6.8
13
15
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
28.5
6.3
8
*
H81.2
ICD-10 Finland
Vestibular neuronitis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
95
2.92
4.66
2.8
1.5
—
—
—
0
0
52
324
2.09
3.65
3.5
3.4
243.4
64.6
e6/l
0.39
39
235
42
249
2.07
3.31
3.3
2.8
0.6
0.3
e6/l
0.40
34
194
20
88
2.54
3.15
7.5
2.5
—
—
—
0
0
45
279
2.00
3.11
7.1
4.4
—
—
—
0
0
24
119
2.28
2.92
3.2
2.1
—
—
—
0
0
44
276
1.95
2.91
3.4
2.9
32.5
57.2
e6/l
0.43
37
219
32
181
2.06
2.81
4.0
1.6
1.3
1.1
mg/l
0.25
26
142
72
536
1.89
2.79
10.3
8.7
4.2
4.0
e9/l
0.28
63
465
64
459
1.87
2.79
9.0
5.4
0.2
0.2
e9/l
0.66
58
409
64
459
1.87
2.79
8.3
5.0
1.9
1.9
e9/l
0.02
59
413
62
443
1.85
2.71
8.4
5.1
0.0
0.0
e9/l
0.65
54
388
62
447
1.82
2.60
3.4
3.7
0.0
0.0
estimate
0.00
12
87
62
447
1.82
2.60
4.8
5.0
0.0
0.0
estimate
0.00
12
87
39
245
1.89
2.52
3.1
2.7
—
—
—
0
0
35
213
1.92
2.48
2.5
3.8
1.0
1.0
kg/l
—
6
27
6
12
5.20
2.43
1.2
2.6
10.8
9.4
mg/l
—
6
12
61
444
1.78
2.42
8.5
5.0
0.6
0.6
e9/l
0.03
53
385
17
82
2.26
2.20
2.3
2.3
487.9
367.2
nmol/l
0.69
17
75
35
221
1.83
2.19
6.1
3.8
—
—
—
0
0
61
454
1.72
2.17
3.5
3.7
0.0
0.0
estimate
0.00
12
85
40
266
1.77
2.11
4.3
3.6
7.3
7.4
ph
—
6
51
12
50
2.56
2.10
7.6
3.1
24.2
24.8
mmol/l
0.21
12
50
37
245
1.75
1.96
9.2
6.2
—
—
—
0
0
6
17
3.66
1.86
1.2
1.1
—
—
—
0
0
19
103
2.01
1.85
1.7
1.3
—
—
—
0
0
7
23
3.17
1.83
5.7
10.8
—
—
—
0
0
82
681
1.68
1.78
5.4
3.7
14.4
11.0
mm/h
1.06
77
614
54
407
1.61
1.72
11.8
8.3
0.0
0.0
e9/l
0.00
41
328
48
353
1.61
1.68
3.1
3.6
—
—
—
0
0
5
14
3.68
1.63
1.0
1.1
—
—
—
0
0
14
71
2.10
1.62
6.6
5.9
—
—
—
0
0
13
64
2.16
1.61
5.8
2.5
91.4
72.0
ng/l
0.36
13
57
20
117
1.86
1.57
1.5
1.3
400.0
591.1
titre
—
5
27
46
340
1.58
1.56
11.6
7.2
1.0
1.2
inr
3.41
13
112
77
641
1.59
1.55
4.7
4.3
—
—
—
0
0
30
200
1.67
1.53
2.7
3.8
—
—
—
0
0
6
22
2.82
1.45
9.2
3.5
1.5
1.4
mmol/l
—
6
22
95
840
1.70
1.41
4.2
4.3
5.7
5.9
mmol/l
0.48
87
753
17
98
1.86
1.40
3.7
6.1
0.6
1.3
mmol/l
0.67
11
75
100
898
1.78
1.38
24.1
13.0
25.3
22.4
mg/l
0.36
87
693
39
289
1.52
1.27
3.1
3.1
—
—
—
0
0
40
302
1.49
1.19
3.4
2.2
—
—
—
0
0
30
213
1.55
1.18
4.7
5.0
—
—
—
0
0
11
59
1.95
1.11
4.1
3.7
—
—
—
0
0
5
21
2.44
1.10
1.6
1.2
310.2
394.5
mg/l
—
5
21
5
21
2.44
1.10
10.8
3.6
10.9
7.5
mmol/l
—
5
21
9
45
2.08
1.08
2.3
1.8
—
—
—
0
0
9
45
2.08
1.08
2.3
2.2
—
—
—
0
0
9
47
1.99
1.05
4.9
2.1
—
—
—
0
0
5
22
2.33
1.04
9.2
2.8
22.2
25.2
mmol/l
—
5
16
11
61
1.89
1.02
3.3
3.8
4.5
4.5
pmol/l
0.03
11
54
97
885
1.56
1.00
5.1
4.6
3.0
2.7
mmol/l
2.61
88
806
7
37
1.95
0.96
1.1
1.8
—
—
—
0
0
10
55
1.89
0.95
1.7
1.2
—
—
—
0
0
6
27
2.29
0.95
2.3
1.3
0.2
0.2
g/l
—
6
27
92
834
1.48
0.94
23.9
13.2
38.3
39.7
%
0.72
71
623
6
28
2.20
0.93
2.3
1.3
1.2
1.2
g/l
—
6
28
34
265
1.40
0.83
3.6
3.1
—
—
—
0
0
6
32
1.92
0.83
2.2
1.2
—
—
—
0
0
6
32
1.92
0.83
1.5
1.2
—
—
—
0
0
6
32
1.92
0.83
1.3
1.6
—
—
—
0
0
6
33
1.86
0.80
15.5
3.2
—
—
—
0
0
14
93
1.57
0.73
2.0
2.1
—
—
—
0
0
16
110
1.53
0.73
1.1
1.2
—
—
—
0
0
5
26
1.96
0.71
6.4
5.0
—
—
—
0
0
5
29
1.76
0.64
16.2
1.7
31.2
20.6
s
—
5
24
5
30
1.70
0.62
1.2
1.2
—
—
—
0
0
8
51
1.61
0.62
5.0
2.2
0.9
1.5
%
—
8
51
0
21
0.00
0.60
0.0
3.7
—
50.6
—
0
21
27
214
1.34
0.60
1.7
1.4
2.6
2.3
g/l
0.56
19
122
87
805
1.31
0.59
5.7
5.5
40.1
39.6
mmol/mol
0.20
82
738
32
262
1.30
0.57
3.7
3.8
0.0
0.0
estimate
0.00
13
85
101
957
1.40
0.56
20.7
12.2
—
—
—
0
0
27
219
1.30
0.51
2.0
3.0
2950.4
57.0
mg/l
0.47
14
136
7
46
1.55
0.49
6.3
3.9
—
—
—
0
0
29
240
1.28
0.48
3.2
3.8
10.9
7.2
mg/mmol
0.22
16
147
41
356
1.23
0.45
2.0
1.8
103.2
97.3
pmol/l
0.19
20
175
16
123
1.35
0.43
1.4
1.6
—
—
—
0
0
41
359
1.22
0.41
2.2
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
1.2
—
0
8
0
18
0.00
0.40
0.0
1.0
—
9.9
—
0
10
14
107
1.35
0.39
1.1
1.2
—
—
—
0
0
5
36
1.41
0.38
1.0
1.5
—
—
—
0
0
29
247
1.23
0.38
2.0
2.8
8.4
7.7
mmol/l
0.25
23
207
67
619
1.19
0.38
3.5
3.5
—
—
—
0
0
5
80
0.61
0.36
8.4
4.9
—
—
—
0
0
6
41
1.49
0.36
4.5
4.0
—
—
—
0
0
6
43
1.42
0.35
1.2
1.1
—
—
—
0
0
37
329
1.18
0.31
6.5
3.8
27.8
36.3
ng/l
0.31
25
228
20
168
1.23
0.29
1.2
1.7
—
—
—
0
0
10
77
1.33
0.27
3.2
3.5
—
—
—
0
0
27
238
1.17
0.25
1.4
1.2
0.7
1.1
u/ml
—
7
65
36
327
1.15
0.23
3.1
2.7
—
—
—
0
0
5
40
1.26
0.22
1.0
1.5
—
—
—
0
0
5
41
1.23
0.22
1.0
1.5
—
—
—
0
0
5
41
1.23
0.22
1.0
1.5
—
—
—
0
0
8
101
0.78
0.22
2.9
2.5
2.1
1.7
%
—
8
87
5
42
1.20
0.22
1.0
1.5
—
—
—
0
0
5
42
1.20
0.22
1.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
88.6
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.9
—
0
5
0
13
0.00
0.21
0.0
1.5
—
32.1
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
14
119
1.20
0.18
1.4
1.7
—
—
—
0
0
22
196
1.15
0.18
1.5
2.0
—
—
—
0
0
10
82
1.24
0.17
1.2
1.2
—
—
—
0
0
5
66
0.75
0.17
1.2
2.4
—
—
—
0
0
5
69
0.71
0.17
2.4
2.8
72.5
72.9
e9/l
—
5
57
6
76
0.78
0.16
6.7
3.6
—
—
—
0
0
6
75
0.79
0.16
1.5
1.4
—
—
—
0
0
9
79
1.15
0.15
1.0
1.1
—
—
—
0
0
27
252
1.09
0.10
7.0
3.7
—
—
—
0
0
6
58
1.04
0.08
1.3
1.3
—
—
—
0
0
5
60
0.83
0.08
1.4
1.2
—
—
—
0
0
8
74
1.09
0.07
1.4
1.6
—
—
—
0
0
8
78
1.03
0.07
1.6
1.3
—
—
—
0
0
18
170
1.07
0.04
2.7
2.4
2.4
2.5
mmol/l
0.24
13
149
11
101
1.10
0.04
1.6
1.3
—
—
—
0
0
31
320
0.96
0.03
3.4
3.0
2.3
2.4
mmol/l
0.56
26
274
11
103
1.08
0.02
1.9
1.5
—
—
—
0
0
26
257
1.02
0.00
1.3
1.5
—
—
—
0
0
16
161
0.99
0.00
1.7
1.2
25.0
42.5
iu/ml
—
5
44
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
4.0
—
0
7
0
6
0.00
0.00
0.0
13.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
26.3
—
0
9
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
2.8
—
0
9
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
10.0
—
0.6
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
30.0
—
1592.3
—
0
6
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
20.5
—
870.8
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
10.4
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_LABYRINTHITIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_LABYRINTHITIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_LABYRINTHITIS – Labyrinthitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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