labyrinthitis: Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [ https://en.wikipedia.org/wiki/Labyrinthitis NCIT:C128369 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
117 |
4. Check minimum number of eventsNone |
117 |
5. Include endpointsNone |
117 |
6. Filter based on genotype QC (FinnGen only) |
117 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H83
- Name in latin
- Labyrinthitis
Similar endpoints
↥List of similar endpoints to
Labyrinthitis
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1255 | 675 | 574 |
| Only index persons | 913 | 513 | 400 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.37 | 39.34 | 32.62 |
| Only index persons | 37.48 | 39.64 | 34.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 117 | 80 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 43.02 | 38.94 | 51.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 108
- Matched controls
- 1080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.0
ICD-10 Finland
Labyrinthitis
+∞
89.4
73
*
38403
ICD-8 Finland
Other inflammatory diseases of ear, Labyrinthitis
+∞
34.2
31
*
R42
ICD-10 Finland
Dizziness and giddiness
4.7
10.6
42
129
H81.3
ICD-10 Finland
Other peripheral vertigo
97.3
8.5
9
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
6.2
7.2
19
36
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
9.7
6.8
13
15
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
28.5
6.3
8
*
H81.2
ICD-10 Finland
Vestibular neuronitis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
272
2.38
4.82
4.5
2.8
34.0
28.3
u/l
1.08
49
256
51
308
2.16
3.95
3.3
2.9
—
—
—
0
0
16
55
3.21
3.91
1.8
1.6
—
—
—
0
0
42
249
2.07
3.31
3.3
2.8
0.6
0.3
e6/l
0.40
34
194
8
16
5.28
3.11
1.6
1.3
—
—
—
0
0
32
181
2.06
2.81
4.0
1.6
1.3
1.1
mg/l
0.25
26
142
72
536
1.89
2.79
10.3
8.7
4.2
4.0
e9/l
0.28
63
465
62
447
1.82
2.60
3.4
3.7
0.0
0.0
estimate
0.00
12
87
62
447
1.82
2.60
4.8
5.0
0.0
0.0
estimate
0.00
12
87
6
12
5.20
2.43
1.7
1.7
—
—
—
0
0
23
121
2.12
2.42
2.4
2.7
3.4
3.6
e6/l
0.05
14
70
7
17
4.31
2.40
2.7
1.7
—
—
—
0
0
7
17
4.31
2.40
2.1
1.6
—
—
—
0
0
5
8
6.47
2.39
2.0
2.3
—
—
—
0
0
5
8
6.47
2.39
2.6
1.1
—
—
—
0
0
5
8
6.47
2.39
2.0
2.3
—
—
—
0
0
5
9
5.74
2.23
1.0
1.8
—
—
—
0
0
5
9
5.74
2.23
1.2
1.8
—
—
—
0
0
17
82
2.26
2.20
2.3
2.3
487.9
367.2
nmol/l
0.69
17
75
7
19
3.85
2.18
2.6
1.7
—
—
—
0
0
61
454
1.72
2.17
3.5
3.7
0.0
0.0
estimate
0.00
12
85
12
50
2.56
2.10
7.6
3.1
24.2
24.8
mmol/l
0.21
12
50
7
20
3.65
2.09
1.1
1.1
—
—
—
0
0
83
679
1.77
2.04
10.3
7.0
82.3
76.4
u/l
0.44
76
630
82
681
1.68
1.78
5.4
3.7
14.4
11.0
mm/h
1.06
77
614
50
369
1.62
1.74
3.6
3.7
—
—
—
0
0
72
582
1.62
1.71
4.4
2.8
48.7
43.2
u/l
0.26
67
550
32
211
1.71
1.70
3.5
2.2
—
—
—
0
0
13
64
2.16
1.61
5.8
2.5
91.4
72.0
ng/l
0.36
13
57
6
20
3.10
1.60
2.2
2.6
—
—
—
0
0
22
133
1.81
1.56
2.7
2.6
2.5
0.9
e6/l
1.27
14
81
51
389
1.55
1.50
2.6
2.1
77.3
75.4
nmol/l
0.15
42
336
5
16
3.22
1.45
1.8
1.2
—
—
—
0
0
95
840
1.70
1.41
4.2
4.3
5.7
5.9
mmol/l
0.48
87
753
17
98
1.86
1.40
3.7
6.1
0.6
1.3
mmol/l
0.67
11
75
100
898
1.78
1.38
24.1
13.0
25.3
22.4
mg/l
0.36
87
693
10
47
2.23
1.38
9.8
3.6
52.3
48.4
%
—
10
47
5
19
2.70
1.23
6.2
1.1
0.0
0.0
g/l
—
5
19
7
30
2.42
1.14
1.4
1.1
—
—
—
0
0
5
21
2.44
1.10
1.6
1.2
310.2
394.5
mg/l
—
5
21
20
131
1.64
1.09
3.3
1.8
—
—
—
0
0
71
607
1.43
1.07
3.7
3.4
—
—
—
0
0
14
83
1.78
1.07
3.6
1.7
—
—
—
0
0
14
83
1.78
1.07
3.2
1.7
—
—
—
0
0
5
22
2.33
1.04
9.2
2.8
22.2
25.2
mmol/l
—
5
16
5
22
2.33
1.04
1.6
1.8
—
—
—
0
0
11
61
1.89
1.02
3.3
3.8
4.5
4.5
pmol/l
0.03
11
54
97
885
1.56
1.00
5.1
4.6
3.0
2.7
mmol/l
2.61
88
806
6
27
2.29
0.95
5.3
1.1
—
—
—
0
0
6
28
2.20
0.93
2.7
1.4
—
—
—
0
0
6
31
1.98
0.85
1.5
1.2
—
—
—
0
0
6
32
1.92
0.83
1.5
1.2
—
—
—
0
0
10
58
1.79
0.82
1.8
1.3
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
6
34
1.80
0.77
1.7
1.3
—
—
—
0
0
26
196
1.42
0.76
2.1
1.6
—
—
—
0
0
91
836
1.40
0.75
18.5
12.0
81.5
82.3
ml/min/173m2
0.12
79
668
7
39
1.84
0.74
2.1
1.5
—
—
—
0
0
13
190
0.64
0.73
1.5
1.5
—
—
—
0
0
5
27
1.89
0.69
2.4
2.1
—
—
—
0
0
5
30
1.70
0.62
1.6
1.3
—
—
—
0
0
8
51
1.61
0.62
5.0
2.2
0.9
1.5
%
—
8
51
13
89
1.52
0.61
3.0
2.0
34.3
28.1
u/l
0.24
13
72
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
87
805
1.31
0.59
5.7
5.5
40.1
39.6
mmol/mol
0.20
82
738
32
262
1.30
0.57
3.7
3.8
0.0
0.0
estimate
0.00
13
85
6
38
1.61
0.55
2.0
1.9
—
—
—
0
0
6
97
0.60
0.55
3.2
4.8
31.7
32.5
%
—
6
57
50
436
1.26
0.54
5.6
4.2
—
—
—
0
0
6
40
1.53
0.52
2.3
2.2
—
—
—
0
0
41
356
1.23
0.45
2.0
1.8
103.2
97.3
pmol/l
0.19
20
175
12
87
1.42
0.44
2.0
3.3
—
—
—
0
0
5
80
0.61
0.36
2.2
2.2
—
—
—
0
0
37
329
1.18
0.31
6.5
3.8
27.8
36.3
ng/l
0.31
25
228
7
56
1.27
0.30
1.1
1.0
—
—
—
0
0
27
238
1.17
0.25
1.4
1.2
0.7
1.1
u/ml
—
7
65
17
144
1.21
0.23
3.8
4.0
19.5
24.5
%
—
9
64
10
112
0.88
0.07
8.8
7.2
—
—
—
0
0
18
170
1.07
0.04
2.7
2.4
2.4
2.5
mmol/l
0.24
13
149
31
320
0.96
0.03
3.4
3.0
2.3
2.4
mmol/l
0.56
26
274
12
124
0.96
0.00
2.3
1.9
—
—
—
0
0
16
161
0.99
0.00
1.7
1.2
25.0
42.5
iu/ml
—
5
44
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
82
0.97
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
3.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
12.9
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.3
—
0
6
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
13.9
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
14
140
1.00
0.00
2.3
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_LABYRINTHITIS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_LABYRINTHITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_LABYRINTHITIS – Labyrinthitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data