Acne varioliformis

L12_ACNE_VARIOLIFORMIS

acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L70.2 Hospital discharge: ICD-9 — 7060A Hospital discharge: ICD-8 — 70601 Cause of death: ICD-10 — L70.2 Cause of death: ICD-9 — 7060A Cause of death: ICD-8 — 70601 2 out of 7 registries used, show all original rules.	93
4. Check minimum number of events None	93
5. Include endpoints None	93
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L70
Name in latin: Acne varioliformis

NAME	L12_ACNE_VARIOLIFORMIS
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L702
HD_ICD_9	7060A
HD_ICD_8	70601
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L702
COD_ICD_9	7060A
COD_ICD_8	70601
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acne varioliformis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	575	296	276
Only index persons	520	275	245
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.38	52.45	56.29
Only index persons	51.46	50.11	52.97

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	52	39
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	51.97	47.48	57.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
93: Matched controls
930

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L70.2

ICD-10 Finland

Acne varioliformis

9551.7

121.5

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.0

10.8

A10AE04

ATC

insulin glargine; parenteral

5.5

9.7

PD4AC

NOMESCO Finland

Arterigography of lower extremity with X-ray

110.8

9.6

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

8.8

9.4

L73.2

ICD-10 Finland

Hidradenitis suppurativa

41.1

9.2

TPH07

NOMESCO Finland

Cathetrisation of artery

5.5

9.1

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

4.9

9.0

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

14.7

8.7

N05BA04

ATC

oxazepam; oral

3.7

8.4

140

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

14.9

8.2

F32.9

ICD-10 Finland

Depressive episode, unspecified

4.3

7.6

SPAT1148

SPAT

Treatment of chronic ulcer or burn

4.4

7.6

ZXE00

NOMESCO Finland

One hour or less

3.3

7.3

245

S97

ICPC

Chronic ulcer skin

7.8

7.2

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

10.6

7.1

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

8.3

7.0

N02AX02

ATC

tramadol; systemic, rectal

3.1

6.5

273

103

Kela drug reimbursment

Diabetes, insulin-treated

3.2

6.4

135

N06AX16

ATC

venlafaxine; oral

3.7

6.4

PEF23

NOMESCO Finland

Thrombendarterectomy of femoral artery

28.8

6.3

A46

ICD-10 Finland

Erysipelas

3.9

6.3

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

4.5

6.3

Z2221

NOMESCO Finland

Medical doctor

3.0

6.1

166

N03AX16

ATC

[U] pregabalin

3.3

6.0

113

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.99

10.94

3.8

1.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

113

3.44

6.64

1.7

1.9

1338.32

1303.15

nmol/l

0.06

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.51

6.63

2.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

284

2.88

5.91

2.1

1.9

88.44

98.40

pmol/l

0.64

144

(3013115) Eosinophils [#/volume] in Blood

369

2.90

5.62

12.8

5.2

0.17

0.18

e9/l

0.18

333

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.43

5.37

8.1

3.7

—

(40758558) Short blood count panel - Blood

196

2.70

5.03

14.1

6.2

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

3.33

4.95

2.0

2.9

22.47

28.57

u/l

0.91

(3024561) Albumin [Mass/volume] in Serum or Plasma

305

2.60

4.86

7.1

3.8

33.84

35.79

g/l

1.09

293

(3011288) Drugs identified in Urine by Screen method

5.63

4.84

5.2

1.7

—

(3006315) Basophils [#/volume] in Blood

359

2.64

4.84

8.2

5.0

0.04

e9/l

0.09

317

(3042936) Bacteria identified in Isolate by Culture

101

3.02

4.80

4.0

2.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

307

2.57

4.76

13.8

5.8

1.21

mmol/l

0.12

287

(3002256) Pathology report gross observation

3.10

4.75

1.5

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

440

2.72

4.65

18.2

8.4

4.90

4.25

e9/l

0.83

391

(3021589) Normoblasts [#/volume] in Blood

340

2.51

4.48

18.3

8.6

0.00

e9/l

0.50

279

(3019198) Lymphocytes [#/volume] in Blood

379

2.52

4.40

8.2

5.0

1.94

1.99

e9/l

0.10

348

(3001604) Monocytes [#/volume] in Blood

361

2.50

4.37

8.4

4.9

0.64

0.57

e9/l

0.99

320

(3009508) Creatinine [Moles/volume] in Urine

208

2.51

4.34

5.8

2.9

6.74

8.04

mmol/l

1.28

178

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

590

3.25

4.28

10.9

6.8

91.70

75.76

u/l

1.81

554

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

334

2.36

3.99

13.5

6.3

1.20

1.21

mmol/l

0.61

282

(3023368) Bacteria identified in Blood by Culture

184

2.45

3.96

9.5

4.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

240

2.37

3.95

4.8

2.9

2.35

mmol/l

0.01

215

(40760892) CBC W Ordered Manual Differential panel - Blood

337

2.33

3.87

9.6

5.4

—

(3018418) pH of Serum or Plasma

202

2.38

3.83

9.6

3.4

7.39

7.41

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

6.10

3.76

3.4

1.7

—

(3026008) Bacteria identified in Urine by Culture

221

2.32

3.69

3.2

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

232

2.27

3.56

4.3

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

506

2.41

3.43

4.9

3.7

—

(3028707) Methadone [Presence] in Urine by Screen method

4.74

3.42

8.1

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.14

3.42

1.9

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.14

3.42

1.9

1.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.73

3.32

19.3

8.7

102.42

104.55

mmol/l

0.77

(40768806) Pleura Pathology biopsy report

9.05

3.31

1.7

2.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

554

2.48

3.27

4.8

3.5

17.59

11.01

mm/h

1.59

515

(3007164) IgA [Mass/volume] in Serum or Plasma

175

2.26

3.22

1.5

1.2

2.95

2.30

g/l

0.57

101

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

110

2.45

3.12

2.2

1.8

—

(3018095) Leukocytes [#/volume] in Urine

286

2.11

3.09

4.8

3.2

183.52

89.17

e6/l

0.37

204

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.63

3.08

2.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

323

2.09

3.04

34.9

11.9

1.31

1.23

inr

0.31

109

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

10.46

3.01

1.0

1.2

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

430

2.11

2.95

11.2

4.7

8.22

6.57

mmol/l

2.74

397

(3016879) Cocaine [Presence] in Urine

3.38

2.90

8.4

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

100

2.42

2.86

1.4

706.67

380.87

titre

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.55

2.82

2.2

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

108

2.36

2.80

3.7

2.7

3.50

2.31

e6/l

0.22

(36304419) Bacteria [Presence] in Urine

217

2.08

2.79

3.9

2.4

—

(36660697) Celiac disease serology panel - Serum

2.74

2.78

1.2

1.1

—

(3028300) Cannabinoids [Presence] in Urine

3.21

2.74

8.7

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

3.21

2.74

8.4

1.3

—

(3027008) Opiates [Presence] in Urine

3.21

2.74

8.4

1.3

—

(3027944) Amphetamines [Presence] in Urine

3.21

2.74

8.6

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

6.32

2.74

4.8

1.1

59.33

63.98

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

132

2.22

2.69

3.8

2.9

490.12

223.42

ng/l

0.32

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.38

2.67

2.0

2.7

4.38

8.55

umol/l

0.64

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.33

2.67

7.8

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

3.87

2.65

2.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

719

2.74

2.64

28.1

12.2

86.80

85.46

ml/min/173m2

0.16

602

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

164

2.12

2.63

4.5

2.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

165

2.10

2.59

1.8

1.7

1.18

0.98

mg/l

0.22

136

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

283

1.97

2.57

4.2

2.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

192

2.02

2.47

1.5

1.6

1.47

1.26

mmol/l

0.71

163

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

114

2.22

2.47

3.2

2.3

1.36

1.11

e6/l

0.15

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.27

2.44

22.9

7.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

389

1.93

2.43

6.2

6.1

10.33

10.38

umol/l

0.02

373

(3000991) Gas panel - Venous blood

2.62

2.43

24.9

8.8

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

6.52

2.40

4.6

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.85

2.31

1.2

1.3

—

(3024928) Oxygen saturation in Venous blood

4.85

2.31

5.3

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

567

2.07

2.30

4.9

3.6

14.49

14.71

pmol/l

0.27

511

(3000492) Spirometry study

2.44

2.25

1.6

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

198

1.94

2.24

4.8

3.8

19.05

9.21

mg/mmol

0.34

130

(3044889) 12 lead EKG panel

506

1.95

2.23

5.1

3.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

332

1.84

2.18

4.7

2.5

147.27

91.27

ug/l

0.87

313

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.40

2.15

1.6

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.30

2.11

2.4

1.7

—

(3012516) Albumin [Mass/volume] in Urine

185

1.92

2.10

3.9

3.0

107.34

69.29

mg/l

0.26

127

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

5.21

2.10

2.0

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

178

1.91

2.06

2.5

1.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

195

1.88

2.04

1.5

1.2

2.66

1.12

u/ml

—

(3031040) Bacteria [#/volume] in Urine by Automated count

495

1.85

1.99

5.5

3.9

—

16.10

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.91

1.99

1.2

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.14

1.99

2.1

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.58

1.93

1.8

1.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

134

1.95

1.88

1.5

1.2

52.72

35.27

iu/ml

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.34

1.84

1.4

1.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.49

1.77

2.7

3.4

5.76

4.40

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.49

1.77

3.0

3.5

66.83

58.33

—

(3021901) Oxygen saturation in Capillary blood

3.49

1.77

7.2

2.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.00

1.74

1.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.73

1.70

2.3

1.5

—

(3000494) Fungus identified in Specimen by Culture

2.07

1.67

1.5

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

108

1.95

1.66

2.2

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.10

1.65

2.6

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

767

2.26

1.55

34.6

12.7

24.93

23.03

mg/l

0.25

592

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.46

1.54

1.0

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

703

1.99

1.48

6.0

4.2

2.32

1.87

mu/l

0.87

639

(3034770) Mitochondria Ab [Titer] in Serum

2.53

1.42

1.1

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

353

1.60

1.40

4.2

2.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.60

1.32

2.8

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.00

1.24

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

2.72

1.23

5.8

4.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.40

1.20

1.5

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.86

1.17

6.2

3.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.36

1.13

4.6

2.0

0.51

0.74

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.04

1.12

2.6

2.5

—

(40768804) Tissue Pathology biopsy report

310

1.51

1.11

2.6

2.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.28

1.11

4.7

2.0

1.01

1.83

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.21

1.08

4.7

2.2

105.00

127.61

g/l

—

(1616796) Gas panel - Central venous blood

2.34

1.04

16.2

3.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

811

2.13

1.02

30.1

14.4

81.49

75.83

umol/l

0.43

811

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.08

1.02

12.3

2.5

24.29

24.69

mmol/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.92

1.02

1.6

2.3

303.89

201.26

ng/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

126

1.64

1.01

1.5

1.3

1.13

5.02

u/ml

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.92

0.96

2.4

1.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.22

0.93

1.5

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

1.88

0.92

1.4

2.1

79.58

69.23

e9/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.99

0.91

1.5

—

(40768443) Skin Pathology biopsy report

2.07

0.88

1.3

1.2

—

(4035726) Immunohistochemistry procedure

1.79

0.87

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

681

1.52

0.82

8.0

5.2

45.09

39.71

mmol/mol

1.88

641

(3025941) Bacteria identified in Stool by Culture

1.73

0.81

1.5

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.87

0.80

1.2

—

(4034850) Laboratory test

0.00

0.80

0.0

7.3

—

(40768797) Stomach Pathology biopsy report

1.61

0.77

1.6

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

170

1.47

0.77

3.5

3.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

138

1.47

0.69

1.6

1.8

454.00

467.04

pmol/l

0.07

117

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

147

1.46

0.69

2.2

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

755

1.56

0.69

5.4

4.5

2.51

2.74

mmol/l

1.36

705

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

185

1.40

0.65

3.1

6511.89

1274.92

ng/l

0.90

154

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

260

1.35

0.63

5.5

3.7

17.23

37.94

ng/l

1.36

172

(1761868) Lipid panel - Serum or Plasma

291

0.72

0.63

3.6

2.5

—

(40761511) CBC panel - Blood by Automated count

811

1.56

0.49

27.2

11.5

—

(3013512) EKG study

194

1.32

0.48

3.9

3.8

—

(3008898) HLA-B27 [Presence]

1.59

0.43

1.2

1.0

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.54

0.42

1.0

1.5

6.49

2.93

mg/l

—

(3002032) Base excess in Venous blood by calculation

1.36

0.41

10.5

2.6

1.36

2.25

mmol/l

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.36

0.41

9.3

2.6

5.75

5.85

kpa

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.41

0.0

1.3

—

64.13

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

3.6

—

24.00

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.39

0.0

1.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.39

0.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.44

0.38

2.8

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.41

0.38

9.0

6.5

—

(3029937) Albumin [Presence] in Urine by Test strip

220

1.25

0.37

5.2

3.3

0.00

0.01

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

230

0.78

0.37

4.9

2.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

745

1.29

0.34

5.0

4.0

4.25

4.63

mmol/l

2.28

702

(3024354) Oxygen [Partial pressure] in Venous blood

1.40

0.32

5.7

2.2

4.67

4.53

kpa

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

741

1.23

0.25

4.9

4.0

1.24

1.46

mmol/l

4.17

691

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

1.60

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

6.74

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

67.70

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3019060) Gas panel - Arterial blood

1.24

0.20

4.0

4.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.24

0.20

1.0

1.1

—

(4200892) Spirometry reversibility

1.24

0.20

1.2

1.3

—

(3019225) pH of Specimen

1.19

0.20

2.2

5.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

174

0.84

0.20

2.8

1.5

—

(3019150) Specific gravity of Urine by Refractometry

168

1.16

0.17

4.0

3.1

—

1.02

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.21

0.17

2.6

1.8

379.63

373.34

nmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.78

0.15

1.4

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

141

1.16

0.15

1.3

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

123

1.16

0.13

3.2

2.3

—

(3022145) Colonoscopy Study observation

1.20

0.13

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

389

1.10

0.12

5.3

4.0

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

391

1.09

0.10

4.3

3.0

0.00

0.01

estimate

0.49

(3003694) ABO and Rh group [Type] in Blood

233

1.10

0.10

1.6

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.17

0.10

1.0

1.3

—

(40761535) Cells panel - Urine sediment

0.80

0.08

5.4

3.3

—

(3009261) Glucose [Presence] in Urine by Test strip

394

1.07

0.08

4.3

3.0

0.00

estimate

—

(3019832) Treponema pallidum Ab [Presence] in Serum

101

0.88

0.06

1.6

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

556

1.07

0.06

4.9

2.8

77.96

40.98

u/l

0.87

535

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

552

0.95

0.05

3.9

3.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

719

1.07

0.05

4.5

3.6

1.47

1.29

mmol/l

1.09

670

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

131

1.08

0.04

3.8

2.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

729

0.95

0.03

5.2

4.1

6.99

5.87

mmol/l

1.70

673

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

302

0.99

0.00

4.5

3.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.0

1.0

—

4.03

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.8

—

6.72

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

52.40

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.6

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.0

—

46.34

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.0

1.0

—

5.94

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.0

—

194.40

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.0

1.0

—

0.49

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

1.4

—

0.15

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1524.20

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.1

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.4

—

0.63

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

107.38

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.3

—

185.75

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

3.39

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

107.67

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

3.75

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.9

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

2.3

—

13.39

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

16.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.89

-0.00

6.4

4.7

24.43

33.28

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACNE_VARIOLIFORMIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_ACNE_VARIOLIFORMIS	3.159 [1.69, 5.9]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.158

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 248 females with L12_ACNE_VARIOLIFORMIS died.

Males

Parameter	HR [95% CI]	p-value
L12_ACNE_VARIOLIFORMIS	2.79 [1.74, 4.47]	< 0.001
Birth year	0.985 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 222 males with L12_ACNE_VARIOLIFORMIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_VARIOLIFORMIS.

N-year risk	Females	Males
1	0.295%	0.545%
5	1.815%	3.121%
10	4.642%	7.312%
15	8.799%	13.825%
20	14.855%	22.752%

Relationships between endpoints

↥

Index endpoint: L12_ACNE_VARIOLIFORMIS – Acne varioliformis

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acne varioliformis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints