This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
125 |
4. Check minimum number of events
Min. number of events
3
|
125 |
5. Include endpointsNone |
125 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Use of riluzole
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 54 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 65.70 | 66.37 | 65.19 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 106
- Matched controls
- 1060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N07XX02
ATC
riluzole; oral
+∞
152.8
106
*
G12.2
ICD-10 Finland
Motor neuron disease
11213.6
137.8
101
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
157.8
40.0
40
*
N99
ICPC
Neurological disease other
178.8
36.3
36
*
J96.1
ICD-10 Finland
Chronic respiratory failure
79.8
34.0
37
7
R47.1
ICD-10 Finland
Dysarthria and anarthria
357.3
28.1
27
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
56.1
25.2
29
7
R4130
NOMESCO Finland
Speech therapy
35.7
19.8
25
9
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
12.5
18.6
35
40
Z51.5
ICD-10 Finland
Palliative care
11.9
16.8
32
37
R13
ICD-10 Finland
Dysphagia
8.9
13.9
31
47
XG466
NOMESCO Finland
Sleep oxymetry
14.2
11.4
19
16
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
10.6
10
*
WX725
NOMESCO Finland
Noninvasive ventilation
11.3
10.3
19
20
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.5
9.8
31
74
TJD20
NOMESCO Finland
Change of gastrostomy tube
40.4
9.2
11
*
N28
ICPC
Limited function/disability (N)
13.2
8.4
14
12
R1260
NOMESCO Finland
Evaluation of communicative skills
19.1
8.3
12
7
R4190
NOMESCO Finland
Nutritional therapy
10.1
7.8
15
17
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
8.3
7.5
16
22
A28
ICPC
Limited function/disability NOS
3.8
7.3
34
117
R1250
NOMESCO Finland
Evaluation of functional capability
13.4
6.7
11
9
R5599
NOMESCO Finland
Other rehabilitation service
10.2
6.5
12
13
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.5
6.3
13
17
L28
ICPC
Limited function/disability (L)
3.5
6.2
32
116
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
967
0.23
15.02
2.7
4.8
1.43
1.44
mmol/l
0.08
45
878
59
993
0.23
14.89
2.7
5.4
2.79
2.68
mmol/l
0.31
46
901
56
971
0.23
14.74
2.6
4.8
4.63
4.56
mmol/l
0.18
45
891
56
942
0.27
12.21
2.4
4.2
1.13
1.30
mmol/l
1.73
47
854
66
968
0.33
8.63
3.0
5.0
5.80
6.02
mmol/l
1.68
56
876
10
11
9.79
8.20
1.0
1.1
—
—
—
0
0
10
12
8.97
7.69
1.0
1.1
—
—
—
0
0
10
5
21.55
7.26
1.0
1.0
—
—
—
0
0
5
268
0.15
6.68
1.2
1.7
1.04
1.30
mmol/l
—
5
221
10
9
11.94
5.91
1.0
1.0
—
—
—
0
0
70
947
0.41
5.57
12.6
14.7
97.95
77.02
ml/min/173m2
9.11
63
779
65
885
0.45
4.64
3.3
4.5
1.93
1.99
mu/l
0.17
60
788
26
506
0.39
4.59
3.3
5.6
0.00
0.00
estimate
—
10
98
85
1042
0.42
4.45
13.7
19.0
54.21
81.04
umol/l
20.49
85
1042
31
550
0.42
4.29
2.8
2.7
—
—
—
0
0
28
505
0.43
3.91
2.7
4.0
0.00
0.00
estimate
—
10
100
29
510
0.44
3.75
2.6
4.0
0.00
0.00
estimate
—
10
91
27
127
2.44
3.70
3.9
5.9
5.80
5.04
kpa
1.49
27
121
63
839
0.50
3.59
15.0
16.5
40.62
40.04
%
0.22
46
581
20
397
0.41
3.42
3.1
4.3
—
—
—
0
0
26
127
2.32
3.26
4.0
5.9
11.19
11.95
kpa
0.40
26
121
26
453
0.46
3.10
3.5
5.3
18.65
2.45
ug/l
0.45
21
405
12
42
3.05
2.84
1.0
2.6
—
—
—
0
0
9
29
3.26
2.27
1.0
3.2
0.00
0.00
g/l
—
9
29
83
972
0.57
2.23
12.3
16.4
32.90
23.34
mg/l
1.26
71
799
22
370
0.51
2.20
4.2
4.7
18.41
21.17
%
—
7
190
30
448
0.57
1.97
2.1
4.4
205.39
46.82
ng/l
0.54
24
338
16
283
0.50
1.82
3.4
4.0
0.00
0.00
estimate
—
10
94
7
156
0.42
1.70
1.0
2.3
2.40
2.30
g/l
—
7
140
66
796
0.64
1.67
15.8
19.4
13.57
13.79
%
1.07
66
782
60
730
0.66
1.50
2.5
4.4
10.93
12.77
mm/h
0.52
55
660
9
41
2.29
1.40
1.1
2.2
39.00
41.07
u/l
—
9
34
17
100
1.81
1.31
2.7
2.2
0.25
0.22
g/l
1.42
17
92
10
51
2.04
1.15
1.7
3.0
0.73
0.71
%
—
10
51
8
150
0.50
1.12
1.1
2.3
18.00
23.50
%
—
8
127
5
22
2.32
1.04
1.2
1.1
—
—
—
0
0
10
54
1.93
1.00
1.7
3.0
0.76
1.26
%
—
10
54
0
28
0.00
0.99
0.0
1.6
—
2.53
—
0
21
0
30
0.00
0.98
0.0
1.6
—
222.56
—
0
25
19
128
1.57
0.92
4.2
6.1
102.37
103.54
mmol/l
0.42
19
122
36
448
0.72
0.85
2.9
4.2
—
—
—
0
0
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
0
25
0.00
0.80
0.0
1.8
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
5
24
2.13
0.75
1.2
1.3
—
—
—
0
0
31
387
0.74
0.73
3.2
3.3
—
—
—
0
0
17
122
1.46
0.64
1.8
2.0
—
—
—
0
0
5
88
0.55
0.58
1.2
1.3
—
—
—
0
0
17
126
1.40
0.55
1.8
2.0
—
—
—
0
0
34
404
0.78
0.55
1.9
2.0
86.62
93.77
pmol/l
0.40
15
203
23
182
1.32
0.51
1.6
2.0
—
—
—
0
0
11
153
0.69
0.49
8.9
27.2
1.32
1.45
inr
—
5
13
7
102
0.67
0.41
1.4
2.6
48.79
7.29
ug/l
—
7
90
0
15
0.00
0.41
0.0
1.1
—
228.29
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
45
502
0.84
0.38
4.1
6.6
1.22
1.21
mmol/l
0.83
38
424
22
181
1.26
0.38
1.5
3.1
0.82
0.82
mmol/l
0.09
16
166
9
119
0.74
0.29
1.4
3.5
5.22
8.39
umol/l
—
9
103
27
308
0.84
0.29
3.1
3.1
0.98
0.63
e6/l
0.26
19
228
8
67
1.21
0.27
1.1
1.4
—
—
—
0
0
5
41
1.23
0.22
1.2
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
98.82
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
1.27
—
0
5
0
10
0.00
0.21
0.0
4.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
4.7
—
97.17
—
0
12
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
13
109
1.22
0.19
6.2
3.9
—
—
—
0
0
7
60
1.18
0.18
2.4
1.8
—
—
—
0
0
13
152
0.84
0.18
1.5
2.1
31.08
29.89
s
0.26
13
146
16
182
0.86
0.16
2.4
2.7
0.92
1.26
e6/l
—
9
106
20
223
0.88
0.16
1.8
2.5
—
—
—
0
0
60
578
1.07
0.11
4.0
10.3
4.25
4.17
e9/l
0.11
53
510
5
44
1.14
0.10
1.2
2.3
—
—
—
0
0
21
227
0.91
0.10
1.0
1.8
462.50
442.86
pmol/l
0.18
16
190
11
124
0.88
0.09
6.6
9.1
—
—
—
0
0
6
71
0.84
0.08
1.2
1.5
—
—
—
0
0
8
77
1.04
0.07
2.3
2.5
296.13
233.91
ng/l
—
8
64
16
171
0.93
0.05
2.4
3.0
0.63
3.23
e6/l
—
8
95
12
124
0.96
0.00
1.1
5.3
207.75
230.87
u/l
1.25
12
117
18
183
0.98
0.00
3.1
4.0
64.89
129.91
ng/l
0.52
18
155
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
13.28
—
0
6
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
22
220
1.00
0.00
1.7
1.8
1.76
1.59
mg/l
0.06
16
174
0
9
0.00
0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
6.1
—
221.71
—
0
7
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
198.33
—
0
9
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
59
0.84
0.00
3.2
3.7
0.17
0.22
e6/l
—
5
59
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: MNMED_RILUZOLE – Use of riluzole
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).