adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
153 |
4. Check minimum number of eventsNone |
153 |
5. Include endpointsNone |
153 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- ILD_SYST_AUTO_DISEASES
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatoid lung disease
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Polyarthropathies
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 998 | 519 | 473 |
| Only index persons | 705 | 370 | 335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 70.83 | 71.81 | 69.83 |
| Only index persons | 70.05 | 70.59 | 69.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | 67 | 84 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 72.47 | 73.23 | 71.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 153
- Matched controls
- 1530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
208.8
220.2
134
50
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
166.8
193.3
138
80
P01BA02
ATC
hydroxychloroquine; oral
62.6
153.6
112
64
A07EC01
ATC
sulfasalazine; oral, rectal
58.8
144.9
98
45
L04AX03
ATC
methotrexate; systemic
43.4
128.4
99
62
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
118.7
98
*
L01BA01
ATC
methotrexate; systemic
69.3
99.9
57
13
L04AA13
ATC
[U] leflunomide
69.3
99.9
57
13
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
48.7
95.5
60
20
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
49.9
94.8
59
19
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
37.8
86.6
59
25
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
48.7
84.1
52
16
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
22.9
75.7
66
49
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
24.0
71.4
59
39
M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
67.9
60
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
17.7
57.4
55
47
J99.0
ICD-10 Finland
Rheumatoid lung disease
+∞
54.5
49
*
H02AB06
ATC
prednisolone; systemic
48.8
50.4
148
577
L04AX01
ATC
azathioprine; systemic
51.7
33.1
39
10
TGC00
NOMESCO Finland
Bronchial lavation
14.7
32.7
32
27
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
89.8
32.5
35
5
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
86.6
31.4
34
5
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.1
29.8
111
414
L88
ICPC
Rheumatoid/seropositive arthritis
35.6
29.8
38
14
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.7
29.1
51
93
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
77.6
23.7
26
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.2
23.1
93
350
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.3
22.2
33
49
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.7
21.3
51
123
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
46.9
20.2
24
6
GD1AD
NOMESCO Finland
Thorax CT examination
7.9
19.5
30
46
M01CB01
ATC
sodium aurothiomalate; parenteral
35.2
19.0
24
8
L04AB01
ATC
etanercept; parenteral
189.8
16.8
17
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
45.6
16.8
20
5
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
53.8
16.4
19
*
M05BA04
ATC
alendronic acid; oral
5.2
15.4
37
88
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.2
14.2
34
80
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
153.0
13.7
14
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
12.1
13.3
24
23
ZX120
NOMESCO Finland
Intravenous
4.6
13.2
37
99
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.4
12.7
28
61
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.3
12.5
23
42
H02AB07
ATC
prednisone; oral
4.1
12.3
42
130
L04AA06
ATC
mycophenolic acid; systemic
29.5
12.3
16
6
R06.0
ICD-10 Finland
Dyspnoea
3.3
11.8
72
325
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
11.6
104
587
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
22.1
11.4
16
8
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
11.2
26
59
M01CB03
ATC
auranofin; oral
47.0
11.1
13
*
L04AB04
ATC
adalimumab; parenteral
47.0
11.1
13
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.1
11.1
23
29
L04AA01
ATC
[U] ciclosporin
30.6
10.9
14
5
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
17.7
10.6
16
10
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.2
9.9
22
48
R50.9
ICD-10 Finland
Fever, unspecified
3.5
9.7
40
140
GX1K5
NOMESCO Finland
Diffusion capacity
106.3
9.5
10
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
15.0
9.4
15
11
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
20.1
9.1
13
7
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
8.9
46
184
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.2
8.9
26
71
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
12.6
8.8
15
13
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
53.1
8.8
10
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
53.1
8.8
10
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
17.6
8.7
13
8
J01MA14
ATC
moxifloxacin; systemic
3.8
8.6
30
93
ZYC01
NOMESCO Finland
Remote contact by phone
5.4
8.6
18
37
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
9.4
8.6
17
20
L04AK01
ATC
leflunomide; oral
95.1
8.5
9
*
N03AX12
ATC
[U] gabapentin; oral
3.2
8.3
41
159
NDL52
NOMESCO Finland
Tenosynovectomy of hand
18.4
8.2
12
7
L04AD01
ATC
ciclosporin; systemic
35.4
8.2
10
*
XG410
NOMESCO Finland
Flow-volume spirometry
6.6
7.7
19
32
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
26.5
7.7
10
*
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
26.5
7.7
10
*
L04AA24
ATC
abatacept; parenteral
84.0
7.5
8
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.4
7.5
30
102
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
+∞
7.3
7
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
7.3
7
*
SPAT1229
SPAT
Assessment of need for aid
3.6
7.2
26
82
R81
ICPC
Pneumonia
7.6
7.2
16
23
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
6.9
7.2
17
27
M01AC06
ATC
meloxicam; systemic, rectal
2.5
7.2
72
400
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.2
7.1
20
53
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
6.9
27
90
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
6.9
45
202
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.1
6.9
20
54
C03CA01
ATC
furosemide; systemic
2.4
6.9
78
456
A02BC02
ATC
pantoprazole; systemic
2.9
6.9
122
879
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.7
6.7
16
26
SPAT1255
SPAT
Intravenous administration of medicine
4.1
6.6
19
51
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
8.0
6.6
14
19
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
72.8
6.5
7
*
GX1D5
NOMESCO Finland
Flow volume spirometry
72.8
6.5
7
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
72.8
6.5
7
*
H02AB04
ATC
methylprednisolone; systemic
2.9
6.4
34
136
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
11.7
6.4
11
10
R03AK08
ATC
formoterol and beclometasone; inhalant
7.6
6.4
14
20
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
27.9
6.3
8
*
ZX140
NOMESCO Finland
Intra articular
27.9
6.3
8
*
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
27.9
6.3
8
*
291
Kela drug reimbursment
Tofacitinib
+∞
6.3
6
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
6.3
6
*
L01EX09
ATC
nintedanib; oral
+∞
6.3
6
*
J990, M058,
ICD-10 Finland
+∞
6.3
6
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
6.3
6
*
J01MA12
ATC
levofloxacin; systemic
2.6
6.3
45
211
NG1DA
NOMESCO Finland
X-ray of knees
10.7
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
27
21.76
52.43
1.7
1.4
0.18
0.06
iu/ml
—
13
6
38
55
8.86
26.36
3.3
3.2
—
—
—
0
0
63
178
5.32
22.06
1.6
1.2
112.59
23.02
u/ml
3.80
30
58
26
32
9.58
20.27
1.5
1.3
—
—
—
0
0
62
191
4.78
19.18
1.5
1.2
136.10
45.16
iu/ml
1.66
44
67
26
40
7.63
16.79
2.2
1.8
—
—
—
0
0
28
24
14.01
16.37
1.4
1.4
—
—
—
0
0
25
40
7.28
15.55
2.9
1.8
—
—
—
0
0
32
66
5.87
15.55
2.5
1.9
2.37
5.74
ug/l
0.35
32
59
21
13
18.49
13.92
1.4
1.4
—
—
—
0
0
60
222
3.80
13.83
3.0
1.9
—
—
—
0
0
51
176
3.85
12.91
5.6
7.2
1.57
1.35
mmol/l
0.16
46
144
46
157
3.76
11.72
2.1
1.9
—
—
—
0
0
45
155
3.70
11.27
2.0
1.8
—
—
—
0
0
22
27
9.32
10.77
2.2
1.6
—
—
—
0
0
22
27
9.32
10.77
2.2
1.6
—
—
—
0
0
22
28
8.98
10.55
1.5
1.9
—
—
—
0
0
31
86
4.27
10.45
5.7
3.5
54.00
57.21
ml/min/173m2
0.26
15
33
89
480
3.04
10.36
2.9
2.3
85.64
77.17
nmol/l
1.75
84
416
110
675
3.24
10.04
6.8
7.2
1.21
1.21
mmol/l
0.01
97
569
18
18
11.17
9.83
2.4
1.7
—
—
—
0
0
18
18
11.17
9.83
2.4
1.7
—
—
—
0
0
18
18
11.17
9.83
2.4
1.7
—
—
—
0
0
20
25
9.03
9.71
1.3
1.1
—
—
—
0
0
19
23
9.26
9.40
1.6
1.9
—
—
—
0
0
20
27
8.35
9.29
1.5
1.9
—
—
—
0
0
19
24
8.87
9.18
1.5
1.9
—
—
—
0
0
17
18
10.47
9.04
3.2
1.7
—
—
—
0
0
94
556
2.79
8.68
5.0
4.1
50.96
34.09
ng/l
0.49
84
421
20
31
7.25
8.53
3.1
1.9
—
—
—
0
0
16
18
9.78
8.27
3.3
1.7
—
—
—
0
0
68
348
2.72
8.27
10.1
4.0
0.00
0.00
estimate
-0.00
21
113
99
619
2.70
7.91
8.7
3.9
0.00
0.00
estimate
-0.00
22
114
15
17
9.65
7.75
1.5
1.7
—
—
—
0
0
15
17
9.65
7.75
1.5
1.7
—
—
—
0
0
97
609
2.62
7.55
8.7
3.9
0.00
0.00
estimate
-0.00
22
131
97
611
2.61
7.47
10.0
5.3
0.00
0.00
estimate
-0.00
22
116
17
38
4.91
7.38
1.5
1.5
—
—
—
0
0
15
19
8.62
7.30
1.0
1.2
—
—
—
0
0
22
63
3.91
7.01
4.2
2.9
1.63
0.99
%
2.12
22
63
26
84
3.52
6.98
5.5
4.1
3.21
2.16
mmol/l
0.98
18
63
21
62
3.77
6.41
3.9
2.9
0.72
0.69
%
0.10
21
62
17
43
4.32
6.36
1.4
1.4
—
—
—
0
0
15
24
6.81
6.34
1.8
1.9
—
—
—
0
0
80
486
2.35
6.32
6.2
3.2
—
—
—
0
0
32
125
2.97
6.29
1.7
2.4
64.61
65.05
g/l
0.10
27
109
87
572
2.21
5.41
4.4
4.4
31.95
34.60
g/l
3.33
81
534
69
416
2.20
5.31
2.9
2.4
55.00
69.81
u/l
0.71
64
383
44
223
2.37
5.09
3.3
2.8
0.93
1.03
e6/l
0.15
32
124
75
480
2.10
4.84
9.8
4.1
—
—
—
0
0
61
376
2.03
4.23
4.6
3.1
0.47
0.50
e6/l
0.05
52
282
21
82
2.81
4.09
4.5
4.0
133.38
127.73
g/l
0.56
21
82
11
22
5.30
4.09
4.3
2.8
4.49
4.49
e9/l
0.00
11
22
7
7
10.40
4.05
1.1
1.0
—
—
—
0
0
11
23
5.07
3.95
4.6
3.1
58.64
57.22
%
0.12
11
23
70
466
1.93
3.81
3.1
2.7
386.08
155.09
ug/l
0.81
65
421
19
74
2.79
3.71
2.6
1.7
—
—
—
0
0
46
272
1.99
3.49
2.6
1.7
2.51
1.63
mg/l
0.42
36
219
7
10
7.27
3.40
3.9
1.5
—
—
—
0
0
7
10
7.27
3.40
3.9
1.5
—
—
—
0
0
18
77
2.52
2.95
1.8
1.4
—
—
—
0
0
14
53
2.81
2.88
4.4
1.8
—
—
—
0
0
63
436
1.76
2.83
2.4
3.4
2.33
2.34
mmol/l
0.20
57
378
15
60
2.66
2.80
1.7
1.2
198.99
125.73
u/ml
0.31
15
51
77
568
1.72
2.74
3.0
2.4
—
—
—
0
0
90
693
1.73
2.73
14.0
15.4
1.26
1.34
inr
0.40
27
203
25
130
2.10
2.64
4.0
2.5
3.59
5.85
ug/l
1.45
25
112
13
51
2.69
2.52
2.8
1.5
—
—
—
0
0
5
8
6.41
2.39
4.8
1.6
—
—
—
0
0
5
8
6.41
2.39
4.8
1.6
—
—
—
0
0
5
8
6.41
2.39
4.8
1.6
—
—
—
0
0
5
8
6.41
2.39
1.0
1.1
—
—
—
0
0
7
17
4.26
2.39
3.9
3.5
—
—
—
0
0
7
17
4.26
2.39
1.9
2.0
—
—
—
0
0
9
28
3.35
2.35
1.2
1.5
—
—
—
0
0
28
159
1.93
2.34
13.0
8.7
—
—
—
0
0
8
24
3.46
2.21
1.0
1.1
—
—
—
0
0
11
44
2.62
2.06
1.8
1.7
—
—
—
0
0
6
15
4.12
2.06
1.0
1.1
—
—
—
0
0
11
45
2.56
1.98
1.4
1.3
—
—
—
0
0
75
587
1.54
1.89
4.2
2.6
—
—
—
0
0
18
97
1.97
1.75
1.7
1.6
—
—
—
0
0
41
285
1.60
1.70
1.8
1.8
1615.75
1221.24
nmol/l
0.74
35
207
5
15
3.41
1.53
1.4
1.3
—
—
—
0
0
9
43
2.16
1.33
1.6
1.1
—
—
—
0
0
6
24
2.56
1.31
1.3
1.6
—
—
—
0
0
5
117
0.41
1.31
1.0
1.2
—
—
—
0
0
9
44
2.11
1.29
1.6
1.1
—
—
—
0
0
6
26
2.36
1.20
1.0
1.1
—
—
—
0
0
19
119
1.68
1.18
3.0
4.4
1.22
1.23
mmol/l
0.16
19
105
0
33
0.00
1.17
0.0
2.1
—
2.20
—
0
25
66
542
1.38
1.15
2.1
2.1
86.83
94.90
pmol/l
0.90
40
268
37
292
1.35
0.80
3.9
2.4
—
—
—
0
0
20
141
1.48
0.79
4.5
3.7
—
—
—
0
0
40
323
1.32
0.74
1.4
1.8
626.35
437.12
pmol/l
1.83
34
268
5
25
2.03
0.73
1.4
1.5
—
—
—
0
0
5
25
2.03
0.73
1.4
1.5
—
—
—
0
0
9
58
1.59
0.71
1.6
1.2
—
—
—
0
0
132
1251
1.40
0.70
39.7
19.9
79.23
82.91
umol/l
0.92
132
1251
27
209
1.35
0.66
1.9
2.5
2.29
2.30
g/l
0.03
27
189
24
308
0.74
0.65
3.4
3.3
0.58
0.82
ug/l
1.21
17
219
29
231
1.32
0.60
1.3
1.2
0.69
1.71
u/ml
—
9
62
0
23
0.00
0.59
0.0
1.5
—
14.84
—
0
23
115
1081
1.26
0.55
4.9
4.8
2.00
2.05
mu/l
0.17
109
938
9
64
1.43
0.52
1.7
2.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
133
1290
1.24
0.34
54.2
24.6
128.71
133.56
g/l
3.70
133
1265
39
436
0.86
0.31
2.8
3.8
3.55
6.19
mg/mmol
0.91
31
281
48
522
0.88
0.26
4.5
5.4
2.09
2.97
ug/l
0.65
43
458
5
42
1.20
0.21
1.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
73
692
1.11
0.21
4.3
3.0
69.78
56.29
u/l
0.24
67
634
0
14
0.00
0.20
0.0
1.0
—
36.14
—
0
9
0
14
0.00
0.20
0.0
1.0
—
549.89
—
0
9
0
14
0.00
0.20
0.0
1.1
—
1.08
—
0
5
6
52
1.16
0.19
1.5
1.1
—
—
—
0
0
15
129
1.18
0.17
1.1
1.4
—
—
—
0
0
24
219
1.11
0.13
4.1
3.1
8.50
2.84
e6/l
0.40
13
124
121
1188
1.09
0.12
5.1
5.5
2.46
2.60
mmol/l
0.93
115
1065
118
1160
1.08
0.10
4.9
5.2
6.02
6.11
mmol/l
0.28
107
1034
5
46
1.09
0.09
1.0
1.7
—
—
—
0
0
6
56
1.07
0.09
1.2
4.1
23.65
23.74
mmol/l
—
6
56
9
87
1.04
0.07
4.4
3.3
0.17
0.26
e6/l
—
9
87
112
1105
1.05
0.06
4.3
4.3
1.41
1.25
mmol/l
1.55
105
981
40
414
0.95
0.05
4.0
4.7
20.82
21.76
%
0.15
24
215
113
1123
1.02
0.01
5.9
6.6
41.27
41.17
mmol/mol
0.04
107
1028
116
1154
1.02
0.00
4.7
4.8
4.35
4.49
mmol/l
0.79
108
1043
114
1134
1.02
0.00
25.8
16.1
74.84
73.99
ml/min/173m2
0.16
103
943
115
1149
1.00
0.00
4.6
4.8
1.44
1.46
mmol/l
0.09
108
1027
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.1
—
71.63
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
96.20
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.33
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMAT_LUNG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 4.335 [3.39, 5.55] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 379 females with RHEUMAT_LUNG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 3.125 [2.41, 4.05] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 351 males with RHEUMAT_LUNG died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMAT_LUNG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.334% | 0.578% |
| 5 | 2.191% | 3.843% |
| 10 | 5.284% | 9.686% |
| 15 | 10.592% | 17.551% |
| 20 | 19.317% | 28.326% |
Relationships between endpoints
↥Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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