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This is a non-core endpoint: only basic statistics are computed.

Hip and thigh

Z21_HIP_THIGH

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 ZA5.1
  • Cause of death: ICD-10 ZA5.1

2 out of 7 registries used, show all original rules.

82

4. Check minimum number of events

None

82

5. Include endpoints

None

82

6. Filter based on genotype QC (FinnGen only)

82

Control definitions (FinnGen only)

Control exclude
Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z[AB]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 82 58 24
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 62.92 59.27 71.73

-FinnGen-

Age distribution of first events

03040506070800246810121416AgeIndividuals

-FinnGen-

Year distribution of first events

19701975198019851990199520002010201520202023024681012141618202224262830YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
74
Matched controls
740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZA5.1
ICD-10 Finland
Hip and thigh
+∞
104.5
74
*
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
31.8
8.8
11
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
9.1
8.6
18
25
M16.1
ICD-10 Finland
Other primary coxarthrosis
4.9
6.0
20
52

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
115
2.85
4.28
5.2
4.1
24.23
53.03
ng/l
0.91
18
89
32
171
2.43
3.53
4.4
3.9
—
—
—
0
0
51
338
2.35
3.40
9.1
5.8
0.04
0.04
e9/l
0.46
46
295
11
34
3.58
3.19
9.9
7.3
—
—
—
0
0
50
337
2.24
3.09
9.3
5.7
0.61
0.59
e9/l
0.22
45
293
64
479
2.53
3.08
5.6
4.6
—
—
—
0
0
51
350
2.21
2.97
10.6
6.0
0.29
0.18
e9/l
0.86
46
307
50
349
2.11
2.69
9.4
5.8
1.93
1.87
e9/l
0.23
45
309
8
20
4.31
2.64
1.3
1.5
—
—
—
0
0
39
250
2.07
2.62
4.0
3.7
142.86
69.43
e6/l
0.34
31
187
36
226
2.06
2.54
4.0
3.1
—
—
—
0
0
36
228
2.03
2.47
11.3
6.0
—
—
—
0
0
54
396
2.06
2.45
12.6
8.9
4.04
4.21
e9/l
0.23
46
346
35
222
2.01
2.37
3.3
3.0
38.14
325.46
e6/l
0.51
30
175
16
75
2.41
2.26
1.5
2.0
92.19
168.31
ug/g
—
9
66
19
97
2.25
2.23
2.2
1.9
—
—
—
0
0
45
323
1.87
2.03
10.6
8.3
1.23
1.22
mmol/l
0.29
38
277
71
597
2.41
2.01
24.4
15.7
37.22
39.65
%
1.22
51
436
25
152
1.93
1.85
3.3
4.2
1.01
1.02
kg/l
—
5
21
21
122
1.97
1.76
1.1
1.2
30.21
4.10
u/ml
—
8
43
57
459
1.79
1.61
3.4
3.8
—
—
—
0
0
23
152
1.71
1.27
3.3
3.8
—
—
—
0
0
6
25
2.51
1.27
1.0
1.2
—
—
—
0
0
8
37
2.28
1.25
1.3
1.3
—
—
—
0
0
28
197
1.64
1.23
5.3
4.1
7.39
7.40
ph
—
6
34
44
346
1.59
1.22
4.3
3.9
0.00
0.00
estimate
—
9
67
15
88
1.86
1.21
1.1
1.8
—
—
—
0
0
49
397
1.58
1.18
8.0
4.9
6.47
6.62
mmol/l
0.27
41
367
28
201
1.60
1.12
3.6
2.9
0.58
0.33
e6/l
0.19
23
153
44
351
1.55
1.12
4.3
3.9
0.00
0.00
estimate
—
10
58
77
714
2.28
1.11
23.0
16.2
78.06
76.36
umol/l
0.23
77
714
38
294
1.55
1.10
2.8
2.7
111.06
101.61
ug/l
0.19
38
277
14
83
1.83
1.10
1.1
1.4
186.67
694.55
titre
—
6
22
35
267
1.54
1.08
3.0
3.7
—
—
—
0
0
27
194
1.58
1.07
3.7
2.8
—
—
—
0
0
12
68
1.90
1.07
2.3
1.9
322.08
380.14
nmol/l
0.31
12
63
16
100
1.75
1.06
5.9
5.9
0.77
0.80
mmol/l
0.82
16
91
43
344
1.53
1.06
5.7
5.5
0.00
0.00
estimate
—
8
66
9
52
1.82
0.96
4.4
4.0
—
—
—
0
0
22
155
1.57
0.94
4.9
4.2
—
—
—
0
0
10
56
1.89
0.92
1.6
2.7
7.26
4.67
ug/l
—
10
50
26
192
1.52
0.91
5.0
3.9
0.00
0.00
estimate
—
9
64
11
65
1.80
0.87
1.5
1.8
—
—
—
0
0
71
648
1.71
0.86
4.4
4.5
4.81
4.62
mmol/l
0.87
71
604
8
46
1.82
0.85
1.4
1.3
—
—
—
0
0
8
47
1.78
0.83
5.5
3.4
—
0.57
—
0
7
34
270
1.44
0.82
3.1
4.4
29.94
32.92
ng/l
0.10
23
187
16
109
1.58
0.78
2.7
2.9
3.45
2.19
e6/l
0.37
11
66
5
23
2.25
0.77
2.2
3.7
—
—
—
0
0
33
265
1.41
0.74
7.5
9.2
1.19
1.27
inr
—
9
86
18
128
1.52
0.74
1.3
1.2
95.17
34.83
iu/ml
—
6
47
7
40
1.82
0.73
1.4
2.0
0.88
1.25
g/l
—
7
34
7
43
1.69
0.69
7.4
4.2
5.01
4.47
pmol/l
—
7
38
33
273
1.35
0.60
2.3
2.0
93.61
96.50
pmol/l
0.15
17
141
6
35
1.77
0.59
2.0
2.9
—
—
—
0
0
9
61
1.53
0.56
20.1
4.8
—
—
—
0
0
9
62
1.51
0.55
3.6
2.4
2.93
3.51
e9/l
—
9
51
35
298
1.30
0.51
15.3
9.1
0.00
0.00
e9/l
0.50
30
245
7
46
1.57
0.50
2.6
3.1
9.13
9.34
g/l
—
7
41
20
157
1.36
0.49
1.6
2.1
2.91
3.05
mg/l
0.08
20
139
69
647
1.42
0.48
4.3
4.4
1.49
1.50
mmol/l
0.11
69
596
12
87
1.44
0.45
1.3
1.3
—
—
—
0
0
24
197
1.31
0.45
3.0
2.3
—
—
—
0
0
8
56
1.47
0.44
4.6
1.9
64.40
65.44
g/l
—
8
51
20
161
1.32
0.42
1.2
1.2
0.74
0.90
u/ml
—
5
49
25
208
1.29
0.42
4.5
3.5
—
—
—
0
0
0
15
0.00
0.41
0.0
3.4
—
—
—
0
0
5
34
1.50
0.41
8.0
13.2
25.56
25.14
mmol/l
—
5
34
0
18
0.00
0.40
0.0
3.3
—
2.22
—
0
13
0
18
0.00
0.40
0.0
3.3
—
4.90
—
0
18
0
18
0.00
0.40
0.0
3.3
—
8.69
—
0
18
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
5
36
1.41
0.39
7.4
13.1
—
—
—
0
0
20
164
1.29
0.37
1.5
1.4
—
—
—
0
0
6
44
1.39
0.35
1.7
1.5
—
—
—
0
0
7
53
1.35
0.32
32.0
8.0
—
—
—
0
0
7
54
1.32
0.31
1.0
1.4
—
—
—
0
0
74
712
1.40
0.31
18.9
13.4
—
—
—
0
0
15
122
1.28
0.29
1.6
1.8
—
—
—
0
0
21
242
0.82
0.27
2.6
2.9
—
—
—
0
0
6
84
0.69
0.25
11.2
5.9
101.67
103.00
mmol/l
—
6
78
5
38
1.34
0.23
15.4
7.9
95.12
93.35
%
—
5
38
5
40
1.27
0.23
1.6
1.1
—
—
—
0
0
65
624
1.20
0.21
4.0
4.0
1.35
1.25
mmol/l
0.63
65
571
0
11
0.00
0.21
0.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
90.78
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
108.50
—
0
12
0
12
0.00
0.21
0.0
3.1
—
3.89
—
0
12
0
13
0.00
0.21
0.0
2.2
—
1.68
—
0
13
0
14
0.00
0.20
0.0
18.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
15.82
—
0
5
6
51
1.19
0.20
2.7
4.0
1.25
1.23
mmol/l
—
6
43
21
186
1.17
0.19
12.8
7.6
—
—
—
0
0
6
76
0.77
0.16
1.2
1.3
—
—
—
0
0
6
78
0.75
0.16
1.3
1.1
—
—
—
0
0
9
77
1.19
0.16
1.7
1.4
—
—
—
0
0
27
288
0.91
0.11
2.1
2.0
—
—
—
0
0
5
43
1.17
0.10
41.2
12.9
25.60
25.07
mmol/l
—
5
43
5
61
0.81
0.08
3.4
3.6
—
—
—
0
0
10
88
1.16
0.08
1.4
1.5
—
—
—
0
0
5
64
0.77
0.08
1.2
1.6
—
—
—
0
0
6
72
0.82
0.08
1.5
1.7
—
—
—
0
0
21
198
1.08
0.06
3.1
4.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
5
59
0.84
0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
23.80
—
0
6
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
7
77
0.90
0.00
6.0
3.4
1.93
1.76
%
—
7
70
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
4.2
—
—
—
0
0
0
5
0.00
0.00
0.0
19.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
0.65
—
0
6
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
5
55
0.90
0.00
3.0
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
31.71
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
57
0.87
0.00
8.8
4.4
82.20
79.95
ng/l
—
5
52
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
9
96
0.93
0.00
1.8
1.7
—
—
—
0
0
5
53
0.94
0.00
3.0
2.6
—
—
—
0
0
5
57
0.87
0.00
1.4
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_HIP_THIGH – Hip and thigh

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).