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This is a non-core endpoint: only basic statistics are computed.

Hip and thigh

Z21_HIP_THIGH

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 ZA5.1
  • Cause of death: ICD-10 ZA5.1

2 out of 7 registries used, show all original rules.

94

4. Check minimum number of events

None

94

5. Include endpoints

None

94

6. Filter based on genotype QC (FinnGen only)

88

Control definitions (FinnGen only)

Control exclude
Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z[AB]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 88 59 29
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 64.16 60.47 71.67

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
94
Matched controls
940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZA5.1
ICD-10 Finland
Hip and thigh
+∞
130.3
94
*
NF1AA
NOMESCO Finland
Hip X-ray examination
11.4
24.6
31
39
M16.1
ICD-10 Finland
Other primary coxarthrosis
6.8
15.3
30
61
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
7.2
13.7
24
43
L13
ICPC
Hip symptom/complaint
4.8
11.7
37
113
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
24.6
8.2
11
5
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
7.4
8.1
19
31
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
17.5
7.4
11
7
M79.6
ICD-10 Finland
Pain in limb
3.2
7.0
56
297
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
8.7
6.4
13
17
N02AX02
ATC
tramadol; systemic, rectal
2.9
6.2
53
287

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
136
2.77
4.66
5.1
3.9
24.38
94.79
ng/l
1.18
21
107
7
5
14.96
4.65
1.1
1.2
—
—
—
0
0
60
382
2.58
4.62
9.0
6.1
0.04
0.04
e9/l
1.12
55
330
60
382
2.58
4.62
9.0
6.1
0.60
0.58
e9/l
0.21
55
330
60
396
2.42
4.07
9.1
6.1
1.94
1.85
e9/l
0.43
55
351
60
396
2.42
4.07
10.5
6.5
0.27
0.17
e9/l
0.93
55
347
37
205
2.33
3.67
4.9
4.2
—
—
—
0
0
6
6
10.56
3.55
1.2
1.2
—
—
—
0
0
64
452
2.30
3.48
13.1
9.3
3.88
4.21
e9/l
0.60
56
396
10
23
4.73
3.42
1.3
1.4
—
—
—
0
0
13
39
3.70
3.39
8.5
7.8
—
—
—
0
0
54
359
2.18
3.37
11.1
6.8
—
—
—
0
0
21
93
2.62
3.33
8.5
6.1
2.28
1.97
mmol/l
0.12
16
78
24
115
2.46
3.24
2.2
2.0
—
—
—
0
0
72
545
2.37
3.17
5.8
4.6
—
—
—
0
0
31
170
2.23
3.08
2.3
2.7
1.20
1.07
mg/l
0.15
26
135
26
135
2.28
2.92
1.2
1.2
27.03
3.91
u/ml
—
9
46
53
372
1.97
2.64
9.6
8.3
1.23
1.22
mmol/l
0.34
48
326
51
358
1.93
2.49
8.5
15.5
1.14
1.31
inr
0.55
13
111
43
288
1.91
2.40
4.3
3.9
128.93
63.33
e6/l
0.35
35
216
39
256
1.89
2.29
3.5
3.3
36.01
282.78
e6/l
0.51
34
203
39
256
1.89
2.29
3.8
3.2
—
—
—
0
0
29
173
1.98
2.25
3.1
4.4
1.01
1.02
kg/l
—
5
25
60
457
1.87
2.16
7.4
5.0
6.76
6.67
mmol/l
0.12
51
423
19
100
2.13
2.04
1.3
1.9
—
—
—
0
0
18
96
2.08
1.86
1.3
1.4
160.00
833.85
titre
—
8
26
66
532
1.81
1.83
3.5
3.8
—
—
—
0
0
17
91
2.06
1.74
1.5
2.1
90.77
157.90
ug/g
—
10
81
28
179
1.80
1.72
3.2
3.8
—
—
—
0
0
71
593
1.81
1.65
4.5
4.0
14.69
14.84
pmol/l
0.20
65
536
6
20
3.13
1.61
2.5
1.1
1.00
2.80
e6/l
—
6
15
5
15
3.46
1.54
2.8
1.1
—
—
—
0
0
6
21
2.98
1.53
2.0
1.6
0.25
0.22
g/l
—
6
21
33
229
1.68
1.51
4.8
4.6
7.39
7.40
ph
—
6
37
44
331
1.62
1.47
3.1
2.8
110.14
108.95
ug/l
0.02
44
309
6
22
2.84
1.46
2.0
1.5
1.26
1.17
g/l
—
6
22
20
121
1.83
1.45
5.8
5.6
0.75
0.80
mmol/l
1.32
20
110
30
206
1.67
1.42
4.3
3.2
1407.11
74.67
mg/l
0.47
25
134
9
41
2.32
1.41
1.2
1.3
—
—
—
0
0
9
42
2.26
1.38
10.1
8.0
95.46
93.45
%
—
9
42
89
825
2.48
1.36
23.7
16.4
77.64
77.29
umol/l
0.05
89
825
22
140
1.75
1.36
1.4
1.3
95.17
33.74
iu/ml
—
6
49
14
78
1.93
1.29
1.5
1.7
—
—
—
0
0
32
230
1.59
1.25
2.9
2.3
—
—
—
0
0
6
26
2.39
1.20
2.0
3.5
—
—
—
0
0
31
223
1.58
1.20
3.9
2.9
—
—
—
0
0
32
232
1.58
1.20
3.8
3.2
0.53
0.36
e6/l
0.15
27
177
11
58
2.02
1.17
4.0
4.2
—
—
—
0
0
49
394
1.51
1.14
4.2
4.1
0.00
0.00
estimate
—
10
75
8
41
2.04
1.12
22.6
5.1
25.38
24.17
mmol/l
—
8
41
13
76
1.82
1.05
2.3
1.8
310.08
378.00
nmol/l
0.42
13
71
9
48
1.97
1.04
1.6
2.1
0.75
1.24
g/l
—
9
42
49
401
1.46
1.01
4.2
4.0
0.00
0.00
estimate
—
10
64
48
394
1.45
0.96
5.5
5.8
0.00
0.00
estimate
—
8
72
6
28
2.22
0.93
1.0
1.2
—
—
—
0
0
10
56
1.88
0.92
1.6
1.4
—
—
—
0
0
19
131
1.56
0.87
3.1
3.2
2.71
2.00
e6/l
0.23
14
81
25
185
1.48
0.84
2.1
2.1
2.60
3.02
mg/l
0.37
25
164
8
47
1.77
0.83
6.6
4.1
5.08
4.51
pmol/l
—
8
41
21
282
0.67
0.82
2.6
3.0
—
—
—
0
0
28
214
1.44
0.80
4.8
3.9
0.00
0.00
estimate
—
9
70
29
224
1.43
0.78
4.7
3.7
4.55
10.87
mg/mmol
1.20
23
135
9
54
1.74
0.77
2.4
3.5
9.33
9.24
g/l
—
9
49
25
190
1.43
0.73
1.4
1.4
—
—
—
0
0
15
103
1.54
0.70
1.3
1.3
—
—
—
0
0
7
43
1.68
0.68
5.9
11.2
—
—
—
0
0
10
62
1.69
0.68
24.0
8.4
—
—
—
0
0
38
317
1.33
0.63
3.1
4.2
27.13
32.78
ng/l
0.23
27
220
0
20
0.00
0.61
0.0
14.9
—
—
—
0
0
14
98
1.50
0.61
1.4
1.4
—
—
—
0
0
38
319
1.32
0.60
2.3
2.0
93.44
95.21
pmol/l
0.09
19
165
27
216
1.35
0.58
13.5
7.8
—
—
—
0
0
9
65
1.42
0.52
4.3
3.1
65.24
65.46
g/l
—
9
60
40
346
1.27
0.49
15.0
9.5
0.00
0.00
e9/l
0.50
34
283
21
167
1.33
0.47
1.5
1.4
2.23
2.39
g/l
0.15
15
98
7
49
1.46
0.47
30.7
11.6
26.29
24.85
mmol/l
—
7
49
23
186
1.31
0.46
1.1
1.2
0.74
1.15
u/ml
—
5
57
8
56
1.47
0.44
5.6
9.6
5.39
5.01
kpa
—
8
56
0
15
0.00
0.41
0.0
2.9
—
16.45
—
0
6
0
17
0.00
0.41
0.0
3.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.2
—
8.68
—
0
19
0
19
0.00
0.39
0.0
3.2
—
4.90
—
0
19
0
19
0.00
0.39
0.0
3.2
—
2.22
—
0
13
5
36
1.41
0.39
1.4
1.2
—
—
—
0
0
85
816
1.43
0.38
18.6
13.5
—
—
—
0
0
6
43
1.42
0.36
2.0
2.8
—
—
—
0
0
6
90
0.64
0.34
1.2
1.3
—
—
—
0
0
7
51
1.40
0.32
1.7
2.9
—
—
—
0
0
17
139
1.27
0.32
1.8
1.8
—
—
—
0
0
8
63
1.29
0.28
3.0
3.8
—
—
—
0
0
11
87
1.30
0.25
4.5
3.5
2.09
1.76
%
1.01
11
80
0
11
0.00
0.21
0.0
2.3
—
90.78
—
0
11
0
11
0.00
0.21
0.0
1.1
—
2.40
—
0
5
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
4.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
1.68
—
0
13
0
14
0.00
0.20
0.0
2.8
—
3.92
—
0
14
0
14
0.00
0.20
0.0
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
2.8
—
108.36
—
0
14
5
68
0.72
0.17
2.4
5.7
—
—
—
0
0
5
68
0.72
0.17
3.4
3.5
—
—
—
0
0
11
92
1.22
0.17
1.8
1.5
—
—
—
0
0
30
324
0.89
0.15
2.4
2.0
—
—
—
0
0
7
89
0.77
0.15
1.9
1.2
—
—
—
0
0
25
232
1.11
0.11
4.5
3.7
—
—
—
0
0
5
48
1.04
0.09
1.6
1.2
—
—
—
0
0
6
56
1.08
0.09
2.7
4.1
1.25
1.22
mmol/l
—
6
48
6
58
1.04
0.08
1.7
1.8
—
—
—
0
0
5
62
0.80
0.08
3.0
2.6
—
—
—
0
0
7
64
1.10
0.08
1.3
1.1
—
—
—
0
0
8
76
1.06
0.07
1.5
1.7
—
—
—
0
0
24
231
1.05
0.03
3.1
4.3
—
—
—
0
0
10
96
1.05
0.00
8.5
6.1
102.40
103.37
mmol/l
—
10
96
11
109
1.01
0.00
1.9
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
69
1.02
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1561.00
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
69
1.02
-0.00
1.7
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
16.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
64
0.93
-0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
70
1.00
-0.00
1.1
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.7
—
0.67
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
50.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
23.80
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
8.28
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
25.43
—
0
6
0
9
0.00
-0.00
0.0
1.8
—
32.22
—
0
9

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_HIP_THIGH – Hip and thigh

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).