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Monocytic leukaemia

CD2_MONOCYTIC_LEUKAEMIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C93
  • Hospital discharge: ICD-9 206
  • Hospital discharge: ICD-8 206
  • Cause of death: ICD-10 C93
  • Cause of death: ICD-9 206
  • Cause of death: ICD-8 206

2 out of 7 registries used, show all original rules.

111

4. Check minimum number of events

None

111

5. Include endpoints

None

111

6. Filter based on genotype QC (FinnGen only)

111

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF8
Parent code in ICD-10
C81-C96
Name in latin
Leuc(h)aemia monocytica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 111 47 64
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 65.71 60.56 69.49

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1008
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C93.1
ICD-10 Finland
Chronic myelomonocytic leukaemia
+∞
46.5
41
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
53.0
46.1
55
22
C93.0
ICD-10 Finland
Acute monoblastic/monocytic leukaemia
+∞
36.7
33
*
XW000
NOMESCO Finland
Bone marrow biopsy
44.3
32.0
39
14
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
+∞
25.0
23
*
9945/3-C42.1
ICD-O-3
Chronic myelomonocytic leukemia, NOS, of bone marrow
+∞
21.6
20
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
246.1
20.3
20
*
WW500
NOMESCO Finland
Blood transfusion
22.0
19.8
29
18
D64.9
ICD-10 Finland
Anaemia, unspecified
7.2
13.2
35
69
R50.9
ICD-10 Finland
Fever, unspecified
6.3
12.0
35
78
C93.9
ICD-10 Finland
Monocytic leukaemia, unspecified
+∞
11.7
11
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.9
11.4
30
58
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.0
10.5
31
69
A04AA01
ATC
ondansetron; systemic, rectal
7.5
9.3
22
36
Z51.5
ICD-10 Finland
Palliative care
7.7
9.1
21
33
M04AA01
ATC
allopurinol; systemic
4.6
9.1
35
104
L01XX05
ATC
hydroxycarbamide; oral
30.5
8.7
11
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.3
8.6
15
14
9891/3-C42.1
ICD-O-3
Acute monocytic leukemia of bone marrow
+∞
8.4
8
*
9860/3-C42.1
ICD-O-3
Myeloid leukemia, NOS, of bone marrow
+∞
8.4
8
*
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
+∞
8.4
8
*
L03AA02
ATC
filgrastim; parenteral
19.2
8.3
12
7
J05AB11
ATC
valaciclovir; oral
4.6
7.1
25
67
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
74.3
6.5
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
8.6
6.3
13
17
A05AA02
ATC
ursodeoxycholic acid; oral
28.6
6.3
8
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
28.6
6.3
8
*
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
+∞
6.3
6
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
6.3
6
*
B03XA02
ATC
darbepoetin alfa; parenteral
11.0
6.2
11
11
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
8.9
6.0
12
15

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
14
26.41
37.55
1.5
1.3
—
—
—
0
0
32
24
18.33
35.50
3.5
1.8
—
—
—
0
0
22
13
20.86
27.07
1.5
1.7
—
—
—
0
0
41
92
6.48
18.95
12.6
3.5
84.0
71.5
e9/l
0.62
35
71
37
82
6.27
17.17
17.7
4.1
1.2
1.0
%
0.29
30
34
35
76
6.27
16.54
15.2
4.2
0.1
0.2
%
0.22
29
30
32
77
5.43
13.32
5.5
2.3
10.0
9.7
g/l
0.13
32
68
30
70
5.50
12.90
14.2
4.5
1.7
0.0
%
0.71
24
25
29
69
5.34
12.15
15.2
3.9
0.5
0.4
%
0.31
21
18
41
153
3.66
9.32
7.4
3.5
0.8
0.8
mmol/l
0.05
41
141
14
21
7.48
9.13
18.0
5.0
—
—
—
0
0
25
71
4.25
8.27
3.0
2.0
—
—
—
0
0
27
83
3.98
8.02
1.7
1.5
—
—
—
0
0
10
12
9.06
7.70
1.2
1.5
—
—
—
0
0
21
55
4.48
7.67
1.5
1.4
—
—
—
0
0
70
417
2.84
6.54
20.5
5.9
2.1
2.5
%
0.55
70
382
70
421
2.79
6.35
22.9
6.2
16.0
8.6
%
6.89
70
387
68
403
2.77
6.35
21.1
5.9
0.6
0.6
%
0.08
68
365
56
301
2.74
6.34
24.3
5.9
—
—
—
0
0
55
298
2.68
6.06
11.4
4.3
—
—
—
0
0
12
24
5.48
5.89
1.8
1.4
—
—
—
0
0
70
434
2.66
5.77
22.4
6.1
26.9
26.8
%
0.02
70
394
31
132
2.87
5.35
1.9
1.8
—
—
—
0
0
28
115
2.92
5.15
1.8
1.7
—
—
—
0
0
27
111
2.89
4.94
1.9
1.5
—
—
—
0
0
32
148
2.63
4.67
2.0
1.8
—
—
—
0
0
11
26
4.59
4.47
2.5
3.3
—
—
—
0
0
69
461
2.31
4.35
20.0
6.3
0.1
0.2
e9/l
1.79
64
404
24
99
2.82
4.34
4.3
5.4
—
—
—
0
0
24
102
2.73
4.09
4.2
5.3
5.7
5.8
kpa
0.17
24
97
51
311
2.18
3.90
17.0
2.5
—
—
—
0
0
7
8
9.24
3.83
2.1
1.3
—
—
—
0
0
7
9
8.20
3.61
4.3
2.3
—
—
—
0
0
32
166
2.30
3.57
3.1
1.5
4.0
2.9
g/l
0.52
26
101
8
13
6.53
3.57
7.3
1.8
33.8
33.8
pg
—
8
13
34
183
2.24
3.47
21.4
6.1
—
—
—
0
0
9
20
4.80
3.19
1.3
1.1
—
—
—
0
0
6
8
7.84
3.09
1.3
1.6
—
—
—
0
0
6
8
7.84
3.09
14.5
6.6
45.5
44.3
%
—
6
8
20
89
2.52
3.09
1.4
1.3
—
—
—
0
0
7
12
6.14
3.07
1.6
1.0
—
—
—
0
0
20
90
2.49
3.02
6.8
6.6
—
—
—
0
0
5
5
10.38
3.00
3.8
1.2
—
—
—
0
0
46
293
1.97
2.96
12.3
4.1
7.4
7.4
ph
—
8
59
6
9
6.97
2.90
1.0
1.1
—
—
—
0
0
11
36
3.28
2.90
4.0
1.4
34.9
36.8
g/l
0.41
11
30
7
14
5.26
2.77
1.3
1.0
—
—
—
0
0
14
55
2.77
2.74
1.1
1.3
—
—
—
0
0
5
7
7.41
2.57
3.8
1.4
—
—
—
0
0
71
857
0.52
2.57
4.8
4.6
1.2
1.4
mmol/l
3.31
64
759
7
16
4.59
2.52
1.6
1.0
—
—
—
0
0
39
247
1.89
2.48
21.8
7.1
—
—
—
0
0
72
863
0.53
2.48
5.1
4.6
4.1
4.4
mmol/l
1.54
66
773
9
27
3.53
2.45
8.4
1.3
0.2
0.2
g/l
—
9
27
75
887
0.52
2.44
5.4
5.1
2.4
2.6
mmol/l
0.84
68
787
59
429
1.80
2.39
14.7
6.1
1.2
1.2
mmol/l
0.50
59
381
18
87
2.28
2.32
1.3
2.6
0.2
0.2
g/l
0.03
18
77
9
29
3.28
2.28
8.4
1.3
1.3
1.2
g/l
—
9
29
9
29
3.28
2.28
1.7
1.3
—
—
—
0
0
69
830
0.55
2.24
4.9
4.2
1.5
1.3
mmol/l
1.25
63
731
5
9
5.75
2.23
1.8
1.3
—
—
—
0
0
21
111
2.10
2.19
3.0
1.2
384.0
535.2
titre
—
5
29
17
83
2.24
2.15
3.0
5.1
4.0
4.3
kpa
0.39
17
78
17
85
2.18
2.03
3.9
4.2
—
—
—
0
0
6
16
3.90
1.96
1.7
1.8
—
—
—
0
0
6
16
3.90
1.96
1.7
1.8
—
—
—
0
0
6
16
3.90
1.96
1.7
1.8
—
—
—
0
0
6
16
3.90
1.96
1.7
1.8
—
—
—
0
0
5
11
4.70
1.96
2.4
1.3
—
—
—
0
0
0
53
0.00
1.93
0.0
1.4
—
—
—
0
0
6
17
3.67
1.86
14.7
2.2
52.0
62.6
%
—
6
17
8
29
2.89
1.83
1.0
1.1
—
—
—
0
0
9
36
2.63
1.78
3.8
6.0
1.3
1.6
%
—
9
31
15
76
2.13
1.74
6.9
3.0
4.8
5.0
kpa
0.32
15
68
55
420
1.61
1.68
8.3
9.7
1.4
1.3
inr
0.53
18
124
10
43
2.46
1.65
9.2
3.8
24.4
25.7
mmol/l
—
10
43
33
225
1.66
1.56
2.2
1.4
—
—
—
0
0
42
308
1.58
1.48
4.0
3.1
—
—
—
0
0
11
54
2.15
1.38
1.8
1.6
—
—
—
0
0
26
172
1.67
1.37
1.2
1.3
1.1
1.4
u/ml
—
9
51
85
937
0.60
1.34
52.1
19.7
92.7
81.9
umol/l
1.65
85
937
9
43
2.19
1.34
1.9
6.4
0.7
0.7
%
—
9
43
9
44
2.14
1.30
3.7
4.8
—
—
—
0
0
17
266
0.57
1.28
3.2
3.3
—
—
—
0
0
6
25
2.48
1.26
1.0
1.1
—
—
—
0
0
83
911
0.65
1.10
36.3
16.0
—
—
—
0
0
11
60
1.93
1.07
7.5
3.5
0.0
0.1
e6/l
1.77
11
60
9
47
1.99
1.05
1.9
6.0
2.0
1.2
%
—
9
47
10
53
1.97
1.05
8.8
3.2
—
—
—
0
0
44
347
1.44
1.05
7.4
3.6
144.2
50.0
e6/l
0.60
36
266
74
827
0.68
1.03
6.5
6.3
40.8
40.9
mmol/mol
0.02
67
754
36
280
1.42
0.91
5.1
3.0
0.8
0.4
e6/l
0.51
31
223
39
308
1.41
0.90
6.5
3.2
38.0
249.5
e6/l
0.54
33
250
79
865
0.70
0.88
5.8
5.0
6.4
6.1
mmol/l
0.70
74
768
53
445
1.37
0.84
6.1
4.1
0.0
0.0
estimate
0.00
12
77
52
436
1.36
0.83
7.5
5.4
0.0
0.0
estimate
0.00
12
83
27
202
1.44
0.83
4.6
4.0
—
—
—
0
0
52
437
1.36
0.82
6.3
4.1
0.0
0.0
estimate
0.00
11
86
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
47
391
1.35
0.78
3.9
4.5
37.5
50.5
ng/l
0.35
35
295
5
24
2.13
0.75
4.6
5.8
50.0
36.1
mg/l
—
5
17
47
393
1.34
0.75
2.9
2.0
83.9
91.8
pmol/l
0.65
30
200
5
25
2.05
0.73
1.8
1.3
—
—
—
0
0
5
26
1.97
0.71
1.2
2.2
116.0
125.1
g/l
—
5
15
5
27
1.89
0.69
2.2
2.1
—
—
—
0
0
12
79
1.58
0.66
6.7
4.1
—
—
—
0
0
14
97
1.51
0.62
6.5
7.0
1.3
1.3
mmol/l
0.05
14
91
13
89
1.52
0.61
1.6
1.3
—
—
—
0
0
33
271
1.31
0.58
5.2
2.9
—
—
—
0
0
6
36
1.70
0.57
2.0
2.6
7.7
8.1
kpa
—
6
30
6
37
1.66
0.56
6.3
3.9
1.4
1.6
mg/l
—
6
32
6
37
1.66
0.56
1.7
3.0
—
—
—
0
0
70
635
1.28
0.56
7.5
4.3
—
—
—
0
0
31
258
1.28
0.49
8.0
4.5
0.0
0.0
estimate
—
9
77
18
141
1.33
0.43
5.8
5.6
11.1
11.4
kpa
0.10
18
133
18
141
1.33
0.43
5.8
5.7
4.9
5.0
kpa
0.18
18
132
5
31
1.64
0.43
1.2
1.2
—
—
—
0
0
16
123
1.35
0.43
5.9
6.2
95.5
95.5
%
0.02
16
118
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
71
659
1.21
0.40
5.5
3.8
14.8
14.9
pmol/l
0.13
66
581
15
117
1.33
0.37
2.1
1.2
—
—
—
0
0
5
76
0.64
0.37
1.2
1.5
—
—
—
0
0
6
43
1.42
0.35
15.0
3.6
4.6
4.4
pmol/l
—
6
38
29
251
1.21
0.33
6.6
3.8
—
—
—
0
0
15
120
1.29
0.32
3.0
1.5
—
—
—
0
0
5
75
0.65
0.26
1.4
1.4
—
—
—
0
0
15
126
1.22
0.22
1.4
1.3
1.2
13.5
u/ml
—
5
44
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
8.0
—
7.4
—
0
5
0
12
0.00
0.21
0.0
3.7
—
3.9
—
0
12
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
6
75
0.79
0.16
3.2
2.2
8.7
14.3
nmol/l
—
6
68
7
85
0.81
0.15
1.3
1.7
—
—
—
0
0
10
85
1.19
0.13
15.0
3.6
—
—
—
0
0
10
85
1.19
0.13
2.5
3.5
—
—
—
0
0
16
143
1.14
0.12
6.1
5.7
1.8
1.2
mmol/l
0.19
11
116
5
48
1.04
0.09
1.0
3.7
13.0
230.6
u/ml
—
5
41
87
886
0.92
0.09
50.0
17.0
30.2
25.7
mg/l
0.69
80
721
38
363
1.07
0.08
3.0
2.1
—
—
—
0
0
6
58
1.04
0.08
1.2
1.2
—
—
—
0
0
6
58
1.04
0.08
1.5
1.2
—
34.7
—
0
5
6
72
0.82
0.08
4.2
2.3
—
—
—
0
0
64
625
1.06
0.06
5.0
4.3
—
—
—
0
0
32
307
1.06
0.06
5.1
3.8
35.6
8.8
mg/mmol
1.04
25
189
30
288
1.06
0.05
5.0
4.3
—
—
—
0
0
12
122
0.98
0.00
1.4
1.4
—
—
—
0
0
76
757
1.01
0.00
41.2
18.0
33.7
39.2
%
2.59
44
510
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
3.2
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
72
720
1.00
0.00
57.2
21.4
15.3
14.0
%
4.07
72
701
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
13.8
—
0
7
0
5
0.00
0.00
0.0
1.0
—
29.2
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_MONOCYTIC_LEUKAEMIA – Monocytic leukaemia

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).