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Monocytic leukaemia

CD2_MONOCYTIC_LEUKAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C93
  • Hospital discharge: ICD-9 206
  • Hospital discharge: ICD-8 206
  • Cause of death: ICD-10 C93
  • Cause of death: ICD-9 206
  • Cause of death: ICD-8 206

2 out of 7 registries used, show all original rules.

121

4. Check minimum number of events

None

121

5. Include endpoints

None

121

6. Filter based on genotype QC (FinnGen only)

113

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF8
Parent code in ICD-10
C81-C96
Name in latin
Leuc(h)aemia monocytica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 113 49 64
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 68.52 64.22 71.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
121
Matched controls
1210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
45.3
101.9
75
42
XW000
NOMESCO Finland
Bone marrow biopsy
28.1
69.5
56
36
C93.1
ICD-10 Finland
Chronic myelomonocytic leukaemia
+∞
68.3
59
*
C93.0
ICD-10 Finland
Acute monoblastic/monocytic leukaemia
+∞
38.6
35
*
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
136.6
37.2
38
*
9945/3-C42.1
ICD-O-3
Chronic myelomonocytic leukemia, NOS, of bone marrow
+∞
36.3
33
*
WW500
NOMESCO Finland
Blood transfusion
10.1
23.7
31
40
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
79.0
18.3
20
*
Z51.5
ICD-10 Finland
Palliative care
6.7
17.7
34
67
D64.9
ICD-10 Finland
Anaemia, unspecified
5.9
17.6
41
97
M04AA01
ATC
allopurinol; systemic
5.5
17.6
47
126
A04AA01
ATC
ondansetron; systemic, rectal
6.5
16.6
32
63
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.2
15.4
41
108
L01XX05
ATC
hydroxycarbamide; oral
41.8
14.9
18
5
R50.9
ICD-10 Finland
Fever, unspecified
4.6
13.3
42
126
C93.9
ICD-10 Finland
Monocytic leukaemia, unspecified
+∞
12.7
12
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.6
12.7
38
109
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
72.1
11.9
13
*
B03XA02
ATC
darbepoetin alfa; parenteral
16.9
9.8
15
10
A05AA02
ATC
ursodeoxycholic acid; oral
33.0
9.6
12
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
13.0
8.9
15
13
9860/3-C42.1
ICD-O-3
Myeloid leukemia, NOS, of bone marrow
+∞
8.4
8
*
127
Kela drug reimbursment
Transplant complication
24.0
8.2
11
5
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.0
7.9
16
20
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
48.1
7.8
9
*
WW200
NOMESCO Finland
Immunization
13.1
7.8
13
11
9891/3-C42.1
ICD-O-3
Acute monocytic leukemia of bone marrow
+∞
7.4
7
*
L03AA02
ATC
filgrastim; parenteral
7.8
7.3
16
23
J05AB11
ATC
valaciclovir; oral
3.3
7.0
32
119
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
42.5
6.8
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
6.9
6.7
16
26
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
13.3
6.7
11
9
L04AA01
ATC
[U] ciclosporin
73.6
6.5
7
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
6.3
53
274
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
28.3
6.3
8
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
6.1
16
40

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
26
22.49
48.28
3.6
1.7
—
—
—
0
0
35
15
32.20
26.71
1.6
1.3
—
—
—
0
0
50
101
7.73
26.25
11.4
3.4
80.50
73.35
e9/l
0.32
41
79
27
15
22.74
18.84
1.6
1.7
—
—
—
0
0
37
82
6.06
17.03
4.9
2.4
10.28
9.94
g/l
0.16
37
73
34
88
4.98
12.88
1.6
1.5
—
—
—
0
0
26
58
5.44
11.61
1.4
1.4
—
—
—
0
0
29
80
4.45
9.99
2.8
2.0
—
—
—
0
0
45
171
3.60
9.89
7.2
3.5
0.80
0.80
mmol/l
0.21
45
158
81
458
3.32
9.02
30.5
6.9
—
—
—
0
0
80
453
3.26
8.82
22.3
5.9
1.95
2.56
%
0.89
80
418
78
436
3.22
8.78
22.8
5.9
0.61
0.61
%
0.02
78
398
34
116
3.69
8.68
1.7
1.5
—
—
—
0
0
80
457
3.22
8.61
25.0
6.2
16.43
8.59
%
8.69
80
423
37
139
3.39
8.10
1.8
1.7
—
—
—
0
0
80
470
3.07
7.95
24.5
6.1
27.14
26.50
%
0.17
80
437
63
329
2.91
7.72
11.4
4.4
—
—
—
0
0
16
21
8.60
7.68
19.1
5.0
—
—
—
0
0
60
338
2.54
5.92
17.3
2.5
—
—
—
0
0
11
13
9.18
5.69
1.2
1.5
—
—
—
0
0
78
503
2.55
5.68
21.1
6.3
0.12
0.18
e9/l
2.51
71
440
76
489
2.49
5.49
17.2
5.9
1.07
0.60
e9/l
2.03
70
424
36
164
2.70
5.42
2.0
1.8
—
—
—
0
0
76
491
2.47
5.41
17.2
5.9
0.04
0.04
e9/l
0.22
70
423
12
18
7.27
5.40
9.2
2.0
—
—
—
0
0
38
180
2.62
5.28
3.3
1.5
3.98
2.84
g/l
0.68
30
110
76
501
2.39
5.03
17.8
6.0
1.69
1.78
e9/l
0.46
71
448
13
25
5.69
4.93
1.8
1.4
—
—
—
0
0
29
125
2.74
4.81
1.7
1.7
—
—
—
0
0
27
114
2.76
4.65
4.4
5.0
5.70
5.84
kpa
0.22
27
109
7
5
14.73
4.63
3.0
1.2
—
—
—
0
0
8
8
10.60
4.59
2.0
1.3
—
—
—
0
0
8
9
9.41
4.35
4.0
2.3
—
—
—
0
0
26
113
2.66
4.22
4.6
5.0
1.31
2.35
mmol/l
0.36
21
84
12
29
4.47
3.82
2.8
3.5
—
—
—
0
0
7
8
9.19
3.82
15.0
6.6
47.29
44.31
%
—
7
8
8
12
7.05
3.73
1.0
1.1
—
—
—
0
0
9
16
5.98
3.73
7.0
1.8
33.56
34.25
pg
—
9
16
23
100
2.61
3.71
6.6
6.8
—
—
—
0
0
23
100
2.61
3.71
1.3
1.4
—
—
—
0
0
8
13
6.50
3.56
1.5
1.0
—
—
—
0
0
10
22
4.85
3.51
1.4
1.1
—
—
—
0
0
22
97
2.55
3.45
1.4
2.6
0.20
0.21
g/l
0.13
22
86
7
10
7.35
3.41
5.0
1.8
28.33
33.78
%
—
7
10
7
10
7.35
3.41
1.0
1.1
—
—
—
0
0
74
531
2.01
3.40
16.8
6.8
1.19
1.21
mmol/l
0.84
67
442
67
471
1.95
3.20
14.7
6.1
1.19
1.20
mmol/l
0.72
67
422
51
327
1.97
3.19
12.0
4.0
7.42
7.40
ph
—
9
69
25
123
2.30
3.09
2.9
1.3
426.67
520.00
titre
—
6
30
11
31
3.80
3.08
7.3
1.3
0.24
0.22
g/l
0.35
11
31
44
271
1.98
3.07
22.3
7.3
—
—
—
0
0
5
5
10.35
3.00
2.0
1.4
1002.40
1014.40
u/ml
—
5
5
8
17
4.96
2.97
1.5
1.0
—
—
—
0
0
12
38
3.39
2.95
3.8
1.4
35.72
36.54
g/l
0.15
12
32
20
92
2.41
2.86
3.5
4.8
4.11
4.20
kpa
0.12
20
87
11
34
3.45
2.81
7.3
1.3
1.29
1.17
g/l
0.74
11
34
5
6
8.62
2.77
1.6
2.3
—
—
—
0
0
10
30
3.54
2.67
1.6
1.3
—
—
—
0
0
7
15
4.88
2.64
1.3
1.0
—
—
—
0
0
10
31
3.42
2.58
1.1
1.1
—
—
—
0
0
40
251
1.89
2.58
2.2
1.4
—
—
—
0
0
6
11
5.67
2.57
1.3
1.9
—
—
—
0
0
29
166
1.98
2.43
4.8
3.0
1.56
1.95
e6/l
0.15
19
102
5
8
6.46
2.39
1.4
1.0
—
—
—
0
0
14
60
2.51
2.32
1.1
1.3
—
—
—
0
0
7
18
4.06
2.29
13.3
2.3
49.14
62.56
%
—
7
18
5
9
5.74
2.23
1.6
4.4
—
—
—
0
0
84
973
0.55
2.20
5.4
5.2
2.41
2.58
mmol/l
0.81
76
866
71
548
1.72
2.18
16.1
15.7
1.47
1.29
inr
0.83
24
168
80
938
0.57
2.17
4.8
4.6
1.21
1.44
mmol/l
3.32
72
833
81
946
0.57
2.15
5.1
4.6
4.12
4.44
mmol/l
1.52
74
850
19
98
2.11
2.09
4.9
4.0
—
—
—
0
0
5
11
4.69
1.96
2.4
1.3
—
—
—
0
0
5
11
4.69
1.96
1.8
1.7
—
—
—
0
0
0
53
0.00
1.92
0.0
1.4
—
—
—
0
0
30
188
1.79
1.90
1.2
1.3
0.97
1.33
u/ml
—
10
56
78
909
0.60
1.84
4.8
4.2
1.46
1.27
mmol/l
1.20
71
804
26
158
1.82
1.81
8.3
7.1
104.38
104.02
mmol/l
0.16
26
158
11
49
2.37
1.69
2.0
5.8
0.67
0.71
%
0.16
11
49
57
436
1.58
1.68
2.9
2.1
81.62
92.10
pmol/l
1.16
39
222
12
56
2.27
1.67
8.7
3.2
—
—
—
0
0
10
43
2.44
1.63
4.5
6.2
1.34
1.58
%
—
10
38
5
14
3.68
1.63
2.6
5.7
—
—
—
0
0
13
64
2.16
1.61
6.9
3.5
0.03
0.12
e6/l
1.11
13
64
12
58
2.19
1.55
1.8
1.6
—
—
—
0
0
47
349
1.57
1.54
4.1
3.0
—
—
—
0
0
7
27
2.69
1.54
1.0
1.1
—
—
—
0
0
51
388
1.54
1.50
7.2
3.6
124.00
50.83
e6/l
0.53
42
294
46
342
1.56
1.50
6.2
3.2
34.48
230.95
e6/l
0.56
39
275
43
317
1.55
1.44
4.9
3.0
0.67
0.46
e6/l
0.38
37
251
11
53
2.18
1.43
2.0
5.5
2.07
1.12
%
0.62
11
53
10
47
2.23
1.38
4.5
4.8
—
—
—
0
0
98
1061
0.60
1.29
74.9
25.1
34.50
39.64
%
7.48
91
990
92
1007
0.64
1.20
37.9
15.7
—
—
—
0
0
95
1032
0.63
1.18
53.7
19.7
91.42
81.46
umol/l
1.63
95
1032
20
294
0.62
1.15
3.0
3.3
—
—
—
0
0
15
89
1.78
1.14
2.1
2.1
103.80
174.14
ug/g
—
10
68
32
235
1.49
1.07
1.5
1.9
488.63
443.90
pmol/l
0.32
27
198
59
491
1.39
1.00
7.5
5.3
0.00
0.00
estimate
-0.00
14
99
60
501
1.39
1.00
6.1
4.1
0.00
0.00
estimate
-0.00
14
93
39
302
1.43
0.99
4.9
2.9
—
—
—
0
0
53
434
1.39
0.99
4.7
4.4
38.23
46.95
ng/l
0.25
40
335
59
493
1.38
0.97
6.2
4.1
0.00
0.00
estimate
-0.00
16
108
6
27
2.28
0.95
1.7
1.3
—
—
—
0
0
6
28
2.20
0.93
3.3
2.3
—
—
—
0
0
30
226
1.44
0.88
4.8
4.0
—
—
—
0
0
81
721
1.37
0.86
5.4
3.8
15.04
14.93
pmol/l
0.13
76
633
19
132
1.52
0.82
2.6
1.5
—
—
—
0
0
78
696
1.34
0.78
7.4
4.2
—
—
—
0
0
5
24
2.13
0.75
2.2
2.6
—
—
—
0
0
5
24
2.13
0.75
3.8
2.8
—
—
—
0
0
19
135
1.48
0.75
6.0
6.8
95.21
95.49
%
0.12
19
130
10
60
1.73
0.74
4.6
7.4
—
—
—
0
0
21
153
1.45
0.73
5.9
6.3
10.77
11.26
kpa
0.20
21
145
21
153
1.45
0.73
5.9
6.3
4.93
5.04
kpa
0.23
21
144
7
40
1.80
0.72
6.1
3.7
1.32
1.60
mg/l
—
7
33
5
27
1.89
0.69
1.8
1.7
—
—
—
0
0
84
909
0.75
0.69
6.3
6.3
40.13
40.94
mmol/mol
0.29
77
831
89
951
0.76
0.61
5.9
5.0
6.36
6.10
mmol/l
0.59
83
845
13
90
1.50
0.58
6.5
4.1
—
—
—
0
0
14
101
1.44
0.52
1.6
1.3
—
—
—
0
0
17
128
1.38
0.51
2.1
1.2
—
—
—
0
0
7
46
1.55
0.49
13.9
3.8
4.59
4.40
pmol/l
—
7
41
13
94
1.43
0.48
2.8
3.9
—
—
—
0
0
5
85
0.57
0.47
1.2
1.5
—
—
—
0
0
37
318
1.24
0.44
5.8
4.3
—
—
—
0
0
5
33
1.54
0.42
2.4
3.3
—
—
—
0
0
18
142
1.31
0.41
1.5
1.3
6.30
13.38
u/ml
—
6
47
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
8
60
1.36
0.41
1.3
1.2
—
—
—
0
0
8
61
1.33
0.40
1.4
1.2
—
34.70
—
0
5
5
35
1.45
0.40
4.6
4.7
—
—
—
0
0
34
293
1.22
0.39
7.9
4.4
0.00
0.00
estimate
-0.00
11
92
12
89
1.39
0.39
15.8
3.6
—
—
—
0
0
6
42
1.45
0.36
1.7
2.9
—
—
—
0
0
44
393
1.19
0.35
3.0
2.0
—
—
—
0
0
19
155
1.27
0.35
6.2
6.3
2.04
1.30
mmol/l
0.30
14
127
7
96
0.71
0.32
1.3
1.6
—
—
—
0
0
32
282
1.18
0.29
6.5
3.7
—
—
—
0
0
11
86
1.31
0.27
3.7
7.3
24.66
24.77
mmol/l
0.02
11
81
6
85
0.69
0.24
1.3
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
5
39
1.29
0.23
1.2
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
2.90
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.3
—
4.32
—
0
14
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
6
78
0.76
0.16
3.2
2.1
9.25
14.47
nmol/l
—
6
71
36
340
1.08
0.11
5.3
3.7
31.95
9.21
mg/mmol
0.96
28
212
81
829
0.93
0.10
61.0
20.7
15.53
15.12
%
0.57
81
811
8
76
1.06
0.07
4.3
2.3
—
—
—
0
0
71
694
1.06
0.07
5.1
4.4
—
—
—
0
0
88
893
0.95
0.05
6.5
4.6
2.06
1.99
mu/l
0.20
83
785
45
437
1.05
0.05
4.3
5.5
1.80
2.90
ug/l
0.76
40
383
13
138
0.94
0.02
1.4
1.3
—
—
—
0
0
97
977
0.96
0.01
51.7
16.9
30.35
26.14
mg/l
0.67
89
796
0
9
0.00
-0.00
0.0
1.1
—
13.28
—
0
9
6
59
1.02
-0.00
3.0
2.4
—
—
—
0
0
5
52
0.96
-0.00
5.4
3.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
1.0
3.5
13.00
216.07
u/ml
—
5
44
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
147.16
—
0
5
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
29.18
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_MONOCYTIC_LEUKAEMIA – Monocytic leukaemia

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).