No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
107 |
4. Check minimum number of eventsNone |
107 |
5. Include endpointsNone |
107 |
6. Filter based on genotype QC (FinnGen only) |
107 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced dystonia
based on the number of shared cases.
Similar with more cases:
- Dystonia
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 816 | 453 | 361 |
| Only index persons | 739 | 416 | 323 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.80 | 52.93 | 43.66 |
| Only index persons | 46.80 | 49.61 | 43.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 107 | 65 | 42 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 46.30 | 48.07 | 43.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 999
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G24.0
ICD-10 Finland
Drug-induced dystonia
+∞
144.2
100
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
40.1
40.7
52
26
N05AH03
ATC
olanzapine; systemic
26.1
30.7
44
29
N04AA02
ATC
biperiden; systemic
63.2
30.1
34
8
N05AX08
ATC
risperidone; systemic
28.0
29.5
41
24
N05AH04
ATC
quetiapine; oral
12.0
26.3
58
103
N05AX12
ATC
aripiprazole; systemic
35.4
25.0
32
13
F29
ICD-10 Finland
Unspecified nonorganic psychosis
42.0
24.5
30
10
N03AE01
ATC
clonazepam; systemic
20.0
22.8
35
26
N03AG01
ATC
valproic acid; systemic, rectal
16.5
20.6
34
30
N05AH02
ATC
clozapine; systemic
42.0
19.0
23
7
N05BA01
ATC
diazepam; systemic, rectal
9.2
17.7
41
70
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
77.2
17.4
19
*
N05AA02
ATC
levomepromazine; systemic
24.4
16.5
23
12
G24.9
ICD-10 Finland
Dystonia, unspecified
72.2
16.4
18
*
N05AD01
ATC
haloperidol; systemic
23.7
15.0
21
11
N05BA06
ATC
lorazepam; systemic, sublingual
14.6
13.7
23
20
N06AX11
ATC
mirtazapine; oral
5.1
13.2
56
198
R56.8
ICD-10 Finland
Other and unspecified convulsions
14.5
13.1
22
19
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
37.6
13.0
16
5
F20.9
ICD-10 Finland
Schizophrenia, unspecified
31.3
12.5
16
6
N06AB04
ATC
citalopram; systemic
5.5
12.5
44
125
T36
ICD-10 Finland
Poisoning by systemic antibiotics
12.5
12.3
22
22
P72
ICPC
Schizophrenia
34.8
12.0
15
5
N05BA04
ATC
oxazepam; oral
5.1
12.0
47
149
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
14.3
11.4
19
16
N05AB03
ATC
perphenazine; systemic, rectal
13.5
11.1
19
17
C07AA05
ATC
propranolol; systemic
5.5
11.0
37
97
N05BE01
ATC
buspirone; oral
16.8
11.0
17
12
G24.3
ICD-10 Finland
Spasmodic torticollis
122.3
10.6
11
*
N05AL01
ATC
sulpiride; systemic
36.9
10.6
13
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
26.8
10.6
14
6
N05CD07
ATC
temazepam; oral
8.0
10.4
24
38
N05AN01
ATC
lithium; oral
19.3
10.2
15
9
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.4
10.2
28
57
N07BB01
ATC
disulfiram; oral
13.4
10.0
17
15
N05AF03
ATC
chlorprothixene; systemic
17.4
9.9
15
10
SPAT1254
SPAT
Administration of medicine
5.9
9.7
29
65
N06AB03
ATC
fluoxetine; oral
5.3
9.4
31
78
N05AE04
ATC
ziprasidone; systemic
55.0
8.8
10
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
18.4
8.8
13
8
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
98.0
8.6
9
*
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
98.0
8.6
9
*
G72.8
ICD-10 Finland
Other specified myopathies
+∞
8.4
8
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
36.6
8.2
10
*
N06AB06
ATC
sertraline; oral
5.3
8.2
26
62
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
12.3
8.1
14
13
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.9
8.0
18
27
N06AX03
ATC
mianserin; oral
12.2
7.5
13
12
G24.8
ICD-10 Finland
Other dystonia
86.2
7.5
8
*
AA1AD
NOMESCO Finland
CT of head and brain
4.1
7.4
31
98
AA400
NOMESCO Finland
Electroconvulsive therapy
+∞
7.4
7
*
P99
ICPC
Psychological disorders other
13.4
7.3
12
10
N05AA01
ATC
chlorpromazine; systemic, rectal
32.6
7.3
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
7.1
33
114
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
43.1
6.9
8
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
11.2
6.7
12
12
N05AC02
ATC
thioridazine; oral
15.7
6.5
10
7
F22.0
ICD-10 Finland
Delusional disorder
74.4
6.5
7
*
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
74.4
6.5
7
*
N05AE05
ATC
lurasidone; oral
74.4
6.5
7
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
12.2
6.5
11
10
N05AF05
ATC
zuclopenthixol; systemic
28.7
6.3
8
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
28.7
6.3
8
*
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
+∞
6.3
6
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
6.2
21
54
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
16.3
6.0
9
6
188
Kela drug reimbursment
Psychosis requiring demanding treatment
16.3
6.0
9
6
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.9
6.0
16
31
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_DYSTON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_DYSTON | 2.337 [1.66, 3.29] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.327 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 404 females with DRUGADVERS_DYSTON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_DYSTON | 3.612 [2.33, 5.59] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 311 males with DRUGADVERS_DYSTON died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_DYSTON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.25% | 0.727% |
| 5 | 1.384% | 4.207% |
| 10 | 3.357% | 10.293% |
| 15 | 6.468% | 18.763% |
| 20 | 11.315% | 30.864% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_DYSTON – Drug-induced dystonia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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