Disorder of carbohydrate metabolism, other/unspecified

E4_CARBONAS

renal glycosuria: An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E74.80, E74.89, E74.9 Hospital discharge: ICD-9 — 271[4-9] Hospital discharge: ICD-8 — 271[8-9] Cause of death: ICD-10 — E74.80, E74.89, E74.9 Cause of death: ICD-9 — 271[4-9] Cause of death: ICD-8 — 271[8-9] 2 out of 7 registries used, show all original rules.	118
4. Check minimum number of events None	118
5. Include endpoints None	118
6. Filter based on genotype QC (FinnGen only)	118

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_CARBONAS
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E74[8-9]
HD_ICD_9	271[4-9]
HD_ICD_8	271[8-9]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E74[8-9]
COD_ICD_9	271[4-9]
COD_ICD_8	271[8-9]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorder of carbohydrate metabolism, other/unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	944	427	508
Only index persons	762	350	412
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	27.25	34.74	20.56
Only index persons	25.83	32.23	20.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	118	51	67
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	23.86	28.29	20.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1111

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

27188

ICD-8 Finland

Congenital disorders of carbohydrate metabolism, Alii definiti

+∞

83.0

27199

ICD-8 Finland

Congenital disorders of carbohydrate metabolism, Unspecified

+∞

12.7

E74.89

ICD-10 Finland

Other specified disorders of carbohydrate metabolism

+∞

7.4

2714A

ICD-9 Finland

Disorders of carbohydrate transport and metabolism, Renal glycosuria

+∞

7.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

366

2.64

6.26

5.9

6.8

1.22

mmol/l

0.34

344

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

395

2.61

6.11

7.3

1.21

mmol/l

0.28

341

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

3.78

4.95

5.4

3.9

71.20

86.77

ng/l

0.35

(3018418) pH of Serum or Plasma

223

2.46

4.93

5.2

3.4

7.39

7.41

—

(3006504) Eosinophils/100 leukocytes in Blood

408

2.17

4.11

7.2

6.0

3.39

3.06

0.55

383

(3024561) Albumin [Mass/volume] in Serum or Plasma

349

2.15

4.00

7.5

4.3

35.84

g/l

0.00

329

(3019069) Monocytes/100 leukocytes in Blood

411

2.14

4.00

7.4

6.4

9.13

8.53

0.76

389

(3022096) Basophils/100 leukocytes in Blood

396

2.12

3.90

7.5

6.1

0.72

0.69

0.22

370

(3048689) Calprotectin [Mass/mass] in Stool

112

2.56

3.81

2.4

2.7

48.88

85.47

ug/g

1.48

(3001604) Monocytes [#/volume] in Blood

431

2.06

3.63

6.8

6.1

0.60

0.58

e9/l

0.31

379

(3006315) Basophils [#/volume] in Blood

433

2.04

3.56

7.0

6.1

0.04

e9/l

0.52

381

(3019309) Folate [Moles/volume] in Red Blood Cells

130

2.40

3.53

2.0

1.7

1360.75

1228.71

nmol/l

0.28

(3002030) Lymphocytes/100 leukocytes in Blood

425

2.03

3.52

7.5

6.2

29.84

29.60

0.06

398

(3028626) Oxygen [Partial pressure] in Capillary blood

3.69

3.42

5.1

9.2

9.42

9.08

kpa

0.24

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

249

2.07

3.30

2.6

2.3

60.53

53.92

u/l

0.85

231

(3041096) Erythrocytes [Presence] in Urine by Automated

226

2.08

3.25

3.5

2.6

—

(3021901) Oxygen saturation in Capillary blood

6.68

3.23

3.4

3.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

270

2.00

3.13

4.7

3.1

2.35

2.36

mmol/l

0.15

243

(42870588) Differential panel, method unspecified - Blood

297

1.97

3.06

7.8

5.6

—

(4035726)

2.63

2.66

1.5

1.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.81

2.63

3.4

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

301

1.87

2.63

2.2

1.8

102.18

99.37

pmol/l

0.14

156

(3029937) Albumin [Presence] in Urine by Test strip

201

1.97

2.63

3.5

3.6

0.00

estimate

0.00

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

202

1.96

2.59

1.7

1.3

3.38

1.82

u/ml

0.33

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.66

2.54

1.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.66

2.54

1.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

323

1.82

2.49

3.3

3.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

352

1.79

2.42

2.7

2.5

131.03

127.78

ug/l

0.05

320

(3009343) pH of Capillary blood

2.56

2.40

5.3

7.0

7.45

7.37

—

(1616796) Gas panel - Central venous blood

6.46

2.39

9.0

7.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

6.46

2.39

6.2

1.9

13.60

11.59

umol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

117

2.08

2.25

1.5

2.0

—

(3021589) Normoblasts [#/volume] in Blood

404

1.73

2.24

14.4

8.5

0.00

e9/l

0.44

323

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

288

1.78

2.22

3.2

2.9

—

(40768797) Stomach Pathology biopsy report

126

2.03

2.17

1.3

—

(3025941) Bacteria identified in Stool by Culture

2.59

1.99

1.1

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

414

1.67

1.99

3.4

3.0

0.00

estimate

0.00

(3035350) Ketones [Presence] in Urine by Test strip

405

1.67

1.98

3.3

2.9

0.00

estimate

0.00

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.10

1.97

1.0

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

407

1.66

1.93

4.5

4.0

0.00

estimate

0.00

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.31

1.91

1.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.21

1.90

4.3

2.2

34.07

29.77

u/l

0.19

(3013707) Erythrocyte sedimentation rate by Westergren method

645

1.68

1.86

4.9

3.9

9.94

10.79

mm/h

0.27

598

(40767503) Oxygen content in Capillary blood by calculation

4.30

1.84

5.4

3.3

17.06

14.90

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.42

1.76

1.1

1.2

—

(3042936) Bacteria identified in Isolate by Culture

121

1.89

1.72

1.9

2.6

—

(3022145) Colonoscopy Study observation

2.01

1.71

1.6

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

299

1.63

1.67

4.3

3.1

23.98

59.29

ng/l

1.24

191

(3032080) INR in Blood by Coagulation assay

293

1.61

1.60

4.5

8.4

1.07

1.24

inr

2.08

(3015736) pH of Urine

304

1.59

1.55

2.6

2.8

—

(3012516) Albumin [Mass/volume] in Urine

210

1.65

1.48

3.6

2.9

2476.90

344.66

mg/l

0.40

140

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

792

1.65

1.47

4.4

4.3

1.75

1.94

mu/l

1.21

727

(3037467) Urinalysis macro (dipstick) panel - Urine

565

1.53

1.45

5.0

3.5

—

(40758558) Short blood count panel - Blood

230

1.60

1.41

6.7

6.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

188

1.64

1.38

1.3

1.5

2.10

2.65

g/l

0.79

110

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.96

1.36

1.4

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

116

0.41

1.34

1.2

2.0

—

(3018095) Leukocytes [#/volume] in Urine

286

1.54

1.34

3.5

3.2

11.43

51.90

e6/l

1.66

204

(3044640) Blood type and Crossmatch panel - Blood

251

1.56

1.32

2.6

2.2

—

(3044889) 12 lead EKG panel

623

1.50

1.30

3.5

—

(40768804) Tissue Pathology biopsy report

315

1.52

1.30

2.1

2.0

—

(40761536) Microorganisms panel - Urine sediment

2.01

1.28

4.5

3.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.85

1.26

1.3

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.47

1.26

1.7

1.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

2.47

1.26

2.8

5.17

97.20

u/ml

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.85

1.19

1.6

1.5

—

(3023368) Bacteria identified in Blood by Culture

204

1.56

1.18

6.6

4.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.13

1.18

1.1

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.56

1.16

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.56

1.16

1.4

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

188

1.57

1.15

4.9

5.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.42

1.14

1.9

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

643

1.46

1.14

3.1

3.3

47.92

43.59

u/l

0.32

610

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

121

0.47

1.13

1.2

2.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.85

1.12

3.5

3.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

217

1.51

1.08

5.0

3.5

7.78

5.60

mg/mmol

0.13

141

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.33

1.04

1.4

1.9

—

(36304419) Bacteria [Presence] in Urine

220

1.49

1.01

2.9

2.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

444

1.40

0.99

7.8

5.8

13.33

11.57

umol/l

0.42

420

(3045414) Leukocytes [Presence] in Urine

2.20

0.93

1.0

1.5

—

(3000991) Gas panel - Venous blood

1.79

0.89

5.7

7.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

190

1.47

0.89

1.9

1.8

0.66

0.79

mg/l

0.28

145

(3005719) IgG [Mass/volume] in Serum or Plasma

1.74

0.89

3.8

2.6

10.52

10.34

g/l

0.06

(36660697) Celiac disease serology panel - Serum

1.70

0.89

1.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

165

1.49

0.86

1.6

1.3

12.70

27.57

iu/ml

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

871

1.47

0.86

3.9

3.7

1.31

1.35

mmol/l

0.22

790

(3000494) Fungus identified in Specimen by Culture

1.61

0.83

1.3

1.6

—

(3022313) Gas panel - Capillary blood

1.71

0.80

6.4

7.4

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.22

0.77

1.0

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.89

0.75

1.6

2.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

912

1.44

0.73

4.8

4.5

2.77

2.83

mmol/l

0.24

840

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.96

0.71

1.0

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

925

1.44

0.70

18.9

11.9

21.60

23.90

mg/l

0.26

712

(3049717) Cytology report of Urine Cyto stain

1.82

0.67

1.2

2.0

—

(3003694) ABO and Rh group [Type] in Blood

230

1.35

0.64

1.2

1.4

—

(3012544) pH of Venous blood

1.56

0.62

5.9

3.8

—

(3000492) Spirometry study

1.50

0.62

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.61

0.62

2.0

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

383

1.28

0.60

4.0

3.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.55

0.60

1.9

1.6

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.70

0.57

3.0

2.7

0.43

0.10

e6/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.57

0.56

13.0

9.5

23.67

25.45

mmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.61

0.55

1.5

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

100

1.45

0.55

1.0

1.7

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.57

0.54

1.5

32.42

27.50

iu/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

101

1.44

0.52

2.9

7.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

138

1.36

0.49

2.9

3.2

8.08

428.09

ng/l

1.09

100

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.52

0.48

2.4

15.1

21.70

24.40

mmol/l

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.46

0.47

2.1

3.2

4.26

4.53

pmol/l

—

(40761511) CBC panel - Blood by Automated count

102

974

1.35

0.46

18.5

10.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

901

1.28

0.44

4.5

4.0

1.48

1.44

mmol/l

0.40

828

(3009542) Hematocrit [Volume Fraction] of Blood

880

1.27

0.43

16.6

12.4

40.39

40.52

0.06

687

(3028026) IgM [Mass/volume] in Serum or Plasma

1.41

0.42

2.0

1.7

1.26

1.49

g/l

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3022621) pH of Urine by Test strip

1.36

0.41

5.4

2.3

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

51.39

—

(40768443) Skin Pathology biopsy report

1.49

0.41

1.0

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

170

1.29

0.41

1.4

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.5

—

(3002256) Pathology report gross observation

1.37

0.39

1.1

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.39

0.0

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

153

1.29

0.38

1.4

1.3

0.83

2.92

u/ml

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

822

1.22

0.38

19.0

10.8

83.35

82.90

ml/min/173m2

0.06

676

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

823

1.22

0.37

6.5

4.8

40.87

39.23

mmol/mol

0.73

770

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

109

1.32

0.35

1.7

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

903

1.20

0.29

4.5

4.1

4.67

4.75

mmol/l

0.31

836

(40761535) Cells panel - Urine sediment

1.23

0.27

2.5

3.3

—

(3003396) Base excess in Arterial blood by calculation

1.33

0.27

2.2

12.7

0.98

1.38

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.66

0.27

1.4

1.8

—

(3019225) pH of Specimen

1.25

0.26

4.7

3.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

190

1.19

0.25

2.5

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.69

0.25

1.5

1.9

—

(3008898) HLA-B27 [Presence]

1.33

0.23

1.2

1.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

271

0.86

0.23

2.8

3.5

19.33

22.08

—

116

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.1

—

24.57

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.2

—

(4062490)

0.00

0.21

0.0

1.3

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.19

0.19

2.3

3.0

52.50

103.19

ng/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

861

1.14

0.19

4.9

4.1

6.16

5.84

mmol/l

1.06

795

(21494755) Public health laboratory ask at order entry panel

119

1.20

0.18

1.2

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

334

1.11

0.16

3.0

3.8

1.49

1.83

ug/l

0.71

302

(1761868) Lipid panel - Serum or Plasma

385

0.91

0.15

3.0

2.5

—

(3013512) EKG study

239

1.11

0.13

4.6

3.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

125

1.14

0.10

2.6

2.7

1.89

1.81

e6/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.14

0.09

1.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

136

1.12

0.09

1.8

2.5

2.01

0.89

e6/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

205

1.09

0.08

1.9

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

620

0.97

0.03

2.7

3.3

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

108

0.92

0.03

4.0

2.3

31.93

28.65

—

103

(3026008) Bacteria identified in Urine by Culture

208

1.01

0.00

4.7

2.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

117

1.03

0.00

1.4

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

207

1.02

0.00

1.9

2.7

0.45

0.69

ug/l

1.67

120

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

13.66

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.01

0.00

1.7

12.4

4.90

5.20

kpa

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.2

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.4

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.00

0.00

1.8

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.8

—

(3017704) Immunofixation for Urine

0.00

0.0

1.8

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1392.00

—

(4024509)

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.6

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3022670) pH of Venous cord blood

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.01

0.00

1.7

12.5

12.09

11.54

kpa

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.4

—

13.67

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.57

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(4010399)

0.89

0.00

1.4

1.5

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.5

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.4

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.2

—

11.50

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

174.17

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3019060) Gas panel - Arterial blood

0.98

0.00

2.2

12.4

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.95

0.00

1.7

1.1

173.67

468.06

u/ml

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

18.6

—

903.71

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

0.97

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.1

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.4

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

20.3

—

1631.29

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(4306422)

0.00

0.0

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.89

0.00

1.6

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.00

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CARBONAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_CARBONAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_CARBONAS – Disorder of carbohydrate metabolism, other/unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Disorder of carbohydrate metabolism, other/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints