renal glycosuria: An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
120 |
4. Check minimum number of eventsNone |
120 |
5. Include endpointsNone |
120 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of carbohydrate metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of carbohydrate metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 944 | 427 | 508 |
| Only index persons | 762 | 350 | 412 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.25 | 34.74 | 20.56 |
| Only index persons | 25.83 | 32.23 | 20.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118 | 50 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 23.98 | 28.73 | 20.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 120
- Matched controls
- 1200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
27188
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Alii definiti
+∞
87.5
73
*
27199
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Unspecified
+∞
13.8
13
*
E74.89
ICD-10 Finland
Other specified disorders of carbohydrate metabolism
+∞
9.5
9
*
2714A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Renal glycosuria
+∞
7.4
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
69
402
2.69
6.54
7.8
7.5
1.21
1.21
mmol/l
0.50
57
347
65
373
2.62
6.28
6.5
7.0
1.22
1.22
mmol/l
0.29
60
349
17
50
3.80
5.25
5.2
4.3
70.60
84.27
ng/l
0.32
17
43
58
355
2.23
4.42
7.5
4.4
35.97
35.83
g/l
0.06
53
334
9
15
6.39
3.89
3.0
4.3
24.44
24.61
mmol/l
—
9
15
27
128
2.43
3.65
2.0
1.7
1360.75
1236.88
nmol/l
0.26
20
97
12
33
3.92
3.40
4.9
9.0
9.42
9.05
kpa
0.28
12
33
45
271
2.06
3.40
4.8
3.1
2.35
2.36
mmol/l
0.24
40
245
43
258
2.04
3.26
2.6
2.3
59.11
55.96
u/l
0.28
36
239
10
25
4.26
3.16
3.2
1.5
—
—
—
0
0
50
331
1.88
2.77
3.4
3.0
—
—
—
0
0
35
206
1.99
2.74
3.7
3.5
0.00
0.00
estimate
-0.00
14
69
46
303
1.84
2.55
2.2
1.8
102.17
100.50
pmol/l
0.08
28
161
52
357
1.81
2.52
2.7
2.5
128.69
126.95
ug/l
0.02
47
326
45
297
1.82
2.47
3.7
2.9
—
—
—
0
0
9
27
3.52
2.45
1.0
1.1
—
—
—
0
0
34
208
1.89
2.35
1.7
1.3
3.38
1.80
u/ml
0.34
12
51
58
421
1.73
2.26
3.5
2.9
0.00
0.00
estimate
-0.00
13
73
57
416
1.71
2.15
4.7
3.9
0.00
0.00
estimate
-0.00
14
71
57
416
1.71
2.15
3.5
2.9
0.00
0.00
estimate
-0.00
13
78
16
77
2.24
2.08
4.1
2.1
33.56
28.93
u/l
0.22
16
60
8
27
3.10
1.97
1.0
1.1
—
—
—
0
0
81
660
1.70
1.95
5.0
3.9
9.90
10.66
mm/h
0.25
73
611
49
354
1.65
1.86
9.5
11.8
1.07
1.23
inr
2.03
17
90
5
12
4.30
1.84
10.0
4.6
54.00
54.67
%
—
5
12
43
303
1.65
1.79
4.3
3.1
23.41
58.39
ng/l
1.26
33
195
7
24
3.03
1.75
1.3
1.3
—
—
—
0
0
5
13
3.96
1.73
5.4
3.2
17.06
14.90
%
—
5
5
7
25
2.91
1.67
1.6
1.1
—
—
—
0
0
6
20
3.10
1.60
1.5
1.5
—
—
—
0
0
32
217
1.65
1.52
4.7
3.3
7.48
6.37
mg/mmol
0.07
22
139
11
52
2.23
1.49
1.1
1.2
—
—
—
0
0
92
804
1.62
1.40
4.4
4.2
1.74
1.92
mu/l
1.05
85
738
16
91
1.87
1.37
3.4
5.1
104.44
104.41
mmol/l
0.01
16
91
5
115
0.41
1.33
1.2
1.9
—
—
—
0
0
14
77
1.93
1.32
4.7
3.4
—
—
—
0
0
5
18
2.85
1.30
2.0
3.1
—
—
—
0
0
6
25
2.47
1.26
1.3
1.8
—
—
—
0
0
76
649
1.47
1.19
3.3
3.3
47.41
43.43
u/l
0.29
71
615
5
21
2.44
1.10
1.0
1.4
—
—
—
0
0
97
878
1.55
1.06
4.0
3.7
1.30
1.35
mmol/l
0.30
90
797
27
195
1.50
0.98
2.0
1.8
0.66
0.83
mg/l
0.38
20
150
55
455
1.39
0.96
8.4
5.8
13.18
11.37
umol/l
0.44
49
431
7
37
1.95
0.95
1.9
1.5
28.49
27.43
iu/l
—
7
28
7
127
0.52
0.95
2.0
2.0
—
—
—
0
0
6
28
2.20
0.93
2.8
3.0
5.17
90.14
u/ml
—
6
22
100
920
1.52
0.91
4.9
4.4
2.75
2.83
mmol/l
0.32
94
850
23
163
1.51
0.91
1.6
1.3
25.41
27.75
iu/ml
—
7
55
9
54
1.72
0.76
2.7
1.5
—
—
—
0
0
9
54
1.72
0.76
1.8
1.6
—
—
—
0
0
101
942
1.46
0.74
19.9
11.9
22.44
23.86
mg/l
0.15
80
727
5
28
1.82
0.67
1.0
1.6
—
—
—
0
0
15
104
1.51
0.66
2.9
7.1
—
—
—
0
0
97
909
1.35
0.59
4.6
4.0
1.48
1.44
mmol/l
0.35
91
838
0
23
0.00
0.59
0.0
1.5
—
—
—
0
0
46
395
1.27
0.57
2.6
2.5
—
—
—
0
0
6
37
1.65
0.56
3.0
2.7
0.43
0.10
e6/l
—
6
37
9
62
1.49
0.54
13.0
9.2
23.67
25.51
mmol/l
—
9
62
7
46
1.55
0.49
2.4
15.3
21.70
24.90
mmol/l
—
7
41
89
834
1.26
0.47
6.8
4.7
40.96
39.14
mmol/mol
0.86
82
779
89
834
1.26
0.47
19.7
10.8
83.16
83.22
ml/min/173m2
0.01
80
691
18
139
1.35
0.47
2.9
3.3
8.08
437.39
ng/l
1.14
13
101
7
49
1.45
0.47
2.1
3.2
4.26
4.54
pmol/l
—
7
41
15
113
1.37
0.45
1.7
1.3
—
—
—
0
0
96
911
1.27
0.43
4.6
4.0
4.65
4.74
mmol/l
0.35
90
847
19
151
1.31
0.42
1.4
1.3
0.83
2.97
u/ml
—
6
60
0
15
0.00
0.41
0.0
3.5
—
7.86
—
0
5
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
22
179
1.28
0.41
1.6
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
51.39
—
0
17
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
91
871
1.19
0.29
4.8
4.1
6.17
5.83
mmol/l
1.14
83
803
24
276
0.84
0.28
2.8
3.6
19.33
21.60
%
—
7
120
108
1054
1.25
0.23
26.7
17.2
40.07
40.69
%
0.52
103
996
7
92
0.75
0.23
1.6
1.9
—
—
—
0
0
10
79
1.29
0.23
2.2
12.6
0.98
1.46
mmol/l
—
5
64
0
11
0.00
0.21
0.0
2.4
—
13.50
—
0
11
0
10
0.00
0.21
0.0
3.1
—
24.57
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
15
127
1.21
0.21
2.7
2.6
1.80
1.81
e6/l
—
10
64
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
52
1.16
0.19
2.3
3.0
52.50
100.99
ng/l
—
6
46
16
138
1.18
0.18
2.0
2.5
1.83
0.88
e6/l
0.23
11
75
37
343
1.11
0.17
3.0
3.9
1.47
1.82
ug/l
0.75
32
310
6
79
0.75
0.16
1.3
1.8
—
—
—
0
0
23
210
1.12
0.13
1.9
2.2
—
—
—
0
0
6
53
1.14
0.09
1.0
1.0
—
—
—
0
0
62
632
0.96
0.04
2.7
3.3
—
—
—
0
0
12
112
1.08
0.03
3.7
2.3
31.52
28.56
s
0.97
12
107
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
81
0.99
-0.00
1.8
12.3
4.89
5.25
kpa
—
8
75
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
21
210
1.00
-0.00
1.9
2.7
0.45
0.69
ug/l
1.69
12
123
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
81
0.99
-0.00
1.8
12.3
12.09
11.39
kpa
—
8
76
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
11.50
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.97
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1392.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_CARBONAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_CARBONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_CARBONAS – Disorder of carbohydrate metabolism, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data