No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
172 |
6. Filter based on genotype QC (FinnGen only) |
172 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of carbohydrate metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1407 | 651 | 742 |
| Only index persons | 1083 | 514 | 569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.79 | 35.37 | 20.72 |
| Only index persons | 26.10 | 32.40 | 20.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 172 | 81 | 91 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 24.99 | 29.17 | 21.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 162
- Matched controls
- 1621
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
27188
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Alii definiti
+∞
78.7
69
*
E74.0
ICD-10 Finland
Glycogen storage disease
+∞
17.0
16
*
27199
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Unspecified
+∞
12.7
12
*
E74.1
ICD-10 Finland
Disorders of fructose metabolism
+∞
11.6
11
*
2714A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Renal glycosuria
+∞
7.3
7
*
2712A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Hereditary fructose intolerance
+∞
7.3
7
*
E74.89
ICD-10 Finland
Other specified disorders of carbohydrate metabolism
+∞
7.3
7
*
Y0599
ICD-8 Finland
Investigation of digestive system
11.7
6.4
11
10
E74.4
ICD-10 Finland
Disorders of pyruvate metabolism and gluconeogenesis
+∞
6.3
6
*
503
Kela drug reimbursment
Inborn metabolic disorders
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
97
578
2.56
8.35
10.4
6.9
1.2
1.2
mmol/l
0.36
79
497
84
501
2.32
6.81
7.7
4.4
36.1
35.9
g/l
0.11
78
473
57
288
2.46
6.71
2.1
2.2
2.9
3.1
mg/l
0.25
50
251
88
539
2.30
6.66
9.2
6.1
1.2
1.2
mmol/l
0.70
78
500
23
75
3.39
6.03
7.6
3.7
92.8
77.1
ng/l
0.34
23
65
41
188
2.55
5.86
2.2
1.7
1279.1
1158.2
nmol/l
0.38
30
145
77
479
2.10
5.28
3.9
2.3
73.2
74.8
nmol/l
0.18
72
428
66
396
2.08
4.91
4.3
2.9
2.4
2.4
mmol/l
0.13
58
355
82
548
1.95
4.40
4.1
2.7
162.9
123.1
ug/l
0.59
76
505
7
6
12.08
4.31
2.1
4.7
36.4
26.8
umol/l
—
7
6
59
356
2.00
4.22
2.8
2.3
56.6
55.6
u/l
0.11
51
329
104
761
1.93
4.18
11.8
9.4
3.5
4.0
e9/l
1.39
97
666
123
953
2.02
4.17
11.0
6.8
85.2
82.4
u/l
0.24
117
892
116
884
1.96
4.09
3.4
3.2
43.2
43.2
u/l
0.01
109
836
69
444
1.93
4.08
2.4
1.8
97.8
97.8
pmol/l
0.00
43
227
67
428
1.93
4.04
4.0
3.1
30.2
50.2
ng/l
0.82
48
273
66
431
1.86
3.65
3.5
3.2
—
—
—
0
0
11
32
3.60
3.39
2.7
5.0
24.4
23.7
mmol/l
0.32
11
27
21
93
2.43
3.18
8.2
6.4
2.1
1.3
mmol/l
1.14
21
87
50
315
1.83
3.03
2.9
3.2
6003.3
1201.0
ng/l
0.58
42
253
25
123
2.21
3.00
8.8
4.5
5.9
5.8
kpa
0.14
25
118
22
103
2.30
2.96
7.7
5.8
4.9
5.2
kpa
1.12
22
95
10
30
3.48
2.95
1.2
1.4
—
—
—
0
0
21
97
2.33
2.91
7.8
6.1
0.1
1.8
mmol/l
1.14
16
74
5
6
8.53
2.76
1.0
1.2
241.4
261.0
mg/l
—
5
6
6
10
6.17
2.72
1.2
1.0
—
—
—
0
0
11
38
3.02
2.63
3.0
1.4
—
—
—
0
0
9
26
3.59
2.52
1.8
3.0
—
—
—
0
0
80
599
1.63
2.52
3.3
3.1
0.0
0.0
estimate
0.00
17
110
66
472
1.65
2.49
3.4
3.3
—
—
—
0
0
7
17
4.24
2.38
4.6
2.9
16.2
16.0
%
—
7
7
82
627
1.59
2.31
10.8
6.0
13.0
11.8
umol/l
0.30
75
595
115
955
1.62
2.26
5.0
4.0
12.9
11.2
mm/h
0.57
105
880
8
24
3.44
2.21
1.4
1.5
—
—
—
0
0
46
308
1.67
2.20
1.7
1.4
3.0
1.5
u/ml
0.37
14
75
46
309
1.67
2.17
3.8
3.6
0.0
0.0
estimate
0.00
18
107
79
607
1.56
2.14
3.4
3.2
0.0
0.0
estimate
0.00
18
111
78
599
1.55
2.11
4.4
4.3
0.0
0.0
estimate
0.00
19
108
6
155
0.37
2.02
1.2
1.8
—
—
—
0
0
5
12
4.26
1.83
1.0
1.2
226.8
193.5
mg/l
—
5
12
7
24
3.00
1.74
1.0
2.4
56.2
301.0
mg/l
—
7
19
7
24
3.00
1.74
1.0
2.4
34.5
24.7
mg/l
—
7
19
20
112
1.89
1.73
4.0
3.2
—
—
—
0
0
112
957
1.49
1.68
4.4
3.7
15.1
14.7
pmol/l
0.86
105
870
132
1170
1.55
1.63
4.9
4.3
1.8
1.9
mu/l
0.89
120
1070
23
139
1.76
1.58
6.6
6.7
—
—
—
0
0
14
72
2.03
1.54
1.7
1.5
—
—
—
0
0
9
37
2.51
1.50
1.0
1.2
—
—
—
0
0
14
73
2.00
1.48
1.1
1.2
—
—
—
0
0
136
1223
1.54
1.47
4.2
3.6
1.3
1.3
mmol/l
0.01
127
1119
5
16
3.19
1.45
1.2
1.2
—
—
—
0
0
5
16
3.19
1.45
1.0
1.9
—
—
—
0
0
11
54
2.11
1.36
3.8
3.7
1.2
1.3
%
0.20
11
54
33
229
1.55
1.35
1.5
1.2
11.1
32.8
iu/ml
—
9
80
8
38
2.16
1.20
1.0
1.2
—
—
—
0
0
145
1341
1.52
1.18
24.2
13.3
4.0
4.0
mmol/l
0.11
140
1305
45
343
1.42
1.17
3.1
2.9
0.2
0.3
e6/l
0.32
40
254
7
30
2.39
1.13
1.7
1.2
—
—
—
0
0
8
40
2.05
1.13
1.6
1.7
—
—
—
0
0
144
1333
1.49
1.13
21.3
12.3
26.0
23.1
mg/l
0.37
116
1021
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
9
46
2.01
1.05
1.4
1.7
—
—
—
0
0
30
217
1.46
1.02
1.3
1.2
0.9
2.5
u/ml
—
8
81
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
5
23
2.21
0.98
1.0
1.7
—
—
—
0
0
5
23
2.21
0.98
1.6
1.8
—
88.1
—
0
5
8
142
0.54
0.98
1.3
1.8
—
—
—
0
0
139
1290
1.40
0.96
5.1
4.3
2.7
2.8
mmol/l
0.55
131
1191
12
70
1.77
0.95
1.8
1.8
—
—
—
0
0
28
204
1.44
0.93
2.6
3.1
9.2
362.9
ng/l
1.51
20
150
8
43
1.90
0.88
1.4
3.8
—
—
—
0
0
8
43
1.90
0.88
1.6
1.5
—
—
—
0
0
10
165
0.58
0.87
1.3
2.0
—
—
—
0
0
136
1268
1.35
0.82
4.8
3.9
1.5
1.4
mmol/l
0.38
128
1170
12
74
1.67
0.80
2.2
3.6
187.8
134.6
ng/l
0.21
12
66
35
273
1.35
0.80
3.0
1.9
1.6
0.9
mg/l
0.30
28
208
8
48
1.70
0.80
3.8
3.6
41.5
50.2
%
—
8
48
136
1274
1.32
0.75
4.7
3.9
4.7
4.7
mmol/l
0.11
128
1187
5
26
1.95
0.71
1.4
1.8
—
—
—
0
0
21
154
1.41
0.69
3.8
4.1
11.5
8.4
umol/l
0.31
16
133
132
1238
1.28
0.67
5.0
4.0
6.1
5.9
mmol/l
0.91
120
1135
22
165
1.38
0.64
4.8
2.4
29.7
29.1
s
0.20
22
160
5
29
1.75
0.64
1.2
1.2
—
—
—
0
0
14
96
1.50
0.64
16.1
8.1
23.8
25.4
mmol/l
1.24
14
96
5
30
1.69
0.62
1.0
1.3
—
—
—
0
0
8
52
1.56
0.60
1.6
2.2
51.1
39.0
u/l
—
8
47
124
1161
1.24
0.60
7.1
4.9
40.2
39.3
mmol/mol
0.43
115
1085
6
36
1.69
0.57
3.3
2.0
—
—
—
0
0
6
36
1.69
0.57
1.7
1.3
—
—
—
0
0
6
36
1.69
0.57
2.8
3.3
5.2
101.0
u/ml
—
6
30
9
65
1.41
0.51
2.9
13.4
22.1
24.4
mmol/l
—
9
59
64
574
1.18
0.45
6.3
3.9
—
—
—
0
0
15
113
1.36
0.44
4.6
10.3
0.4
1.4
mmol/l
—
10
86
5
31
1.63
0.43
1.0
1.6
—
—
—
0
0
5
33
1.53
0.41
1.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.6
—
11.3
—
0
5
5
34
1.48
0.40
1.0
1.9
—
—
—
0
0
32
272
1.22
0.40
1.4
1.7
—
—
—
0
0
134
1285
1.19
0.39
21.6
12.7
39.0
40.4
%
0.99
101
1013
49
446
1.14
0.28
3.3
4.1
1.7
2.6
ug/l
0.63
44
397
8
66
1.22
0.27
2.1
3.4
4.3
4.6
pmol/l
—
8
57
17
142
1.22
0.26
4.8
3.9
31.2
30.8
%
0.04
11
93
14
115
1.24
0.24
4.4
10.2
12.1
12.3
kpa
0.06
14
110
14
115
1.24
0.24
4.4
10.2
4.8
5.2
kpa
0.96
14
109
98
936
1.11
0.24
3.0
3.3
—
—
—
0
0
5
37
1.36
0.23
1.0
1.1
—
—
—
0
0
32
354
0.88
0.22
3.2
3.6
20.3
21.5
%
—
9
152
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
13.1
—
0
10
0
13
0.00
0.21
0.0
2.8
—
33.0
—
0
13
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
121
1178
1.09
0.17
20.4
10.9
84.3
84.0
ml/min/173m2
0.04
106
958
11
129
0.84
0.15
1.8
1.8
—
—
—
0
0
23
208
1.12
0.15
2.2
2.6
2.1
0.9
e6/l
0.36
13
116
32
301
1.08
0.10
6.5
2.2
—
—
—
0
0
10
87
1.16
0.09
1.2
1.2
91.6
136.7
iu/ml
—
5
35
8
76
1.06
0.07
2.6
1.7
—
—
—
0
0
8
77
1.04
0.07
1.0
1.0
—
—
—
0
0
21
197
1.08
0.06
2.8
2.7
1.6
1.8
e6/l
0.06
11
105
19
182
1.05
0.02
1.6
1.4
—
—
—
0
0
12
126
0.95
0.00
1.8
1.8
—
—
—
0
0
19
187
1.02
0.00
1.6
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
27
270
1.00
0.00
1.7
2.8
0.5
0.7
ug/l
1.06
15
163
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
3.2
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
18.7
—
0
6
7
74
0.94
0.00
2.1
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_CARBO and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_CARBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_CARBO – Other disorders of carbohydrate metabolism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data