No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
174 |
6. Filter based on genotype QC (FinnGen only) |
169 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of carbohydrate metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1407 | 651 | 742 |
| Only index persons | 1083 | 514 | 569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.79 | 35.37 | 20.72 |
| Only index persons | 26.10 | 32.40 | 20.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 169 | 80 | 89 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 25.01 | 29.17 | 21.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
27188
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Alii definiti
+∞
83.1
73
*
E74.0
ICD-10 Finland
Glycogen storage disease
+∞
18.0
17
*
27199
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Unspecified
+∞
13.7
13
*
E74.1
ICD-10 Finland
Disorders of fructose metabolism
+∞
11.6
11
*
E74.89
ICD-10 Finland
Other specified disorders of carbohydrate metabolism
+∞
9.5
9
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
8.8
24
62
2712A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Hereditary fructose intolerance
+∞
8.4
8
*
1310
FHL
Esophagogastroscopy
+∞
7.3
7
*
503
Kela drug reimbursment
Inborn metabolic disorders
+∞
7.3
7
*
2714A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Renal glycosuria
+∞
7.3
7
*
E74.4
ICD-10 Finland
Disorders of pyruvate metabolism and gluconeogenesis
+∞
7.3
7
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.7
7.3
25
76
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.4
7.2
28
93
UJF32
NOMESCO Finland
Coloscopy
2.5
6.5
51
248
Y0599
ICD-8 Finland
Investigation of digestive system
9.8
6.4
12
13
A02BC05
ATC
esomeprazole; systemic
2.3
6.3
74
428
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
6.3
43
195
Z31.5
ICD-10 Finland
Genetic counselling
4.2
6.1
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
99
584
2.61
8.82
10.7
7.1
1.21
1.21
mmol/l
0.47
83
504
86
506
2.38
7.30
7.7
4.5
36.21
35.89
g/l
0.20
80
477
58
291
2.49
6.95
2.1
2.2
2.92
3.10
mg/l
0.23
51
254
89
543
2.31
6.82
9.6
6.3
1.22
1.21
mmol/l
0.75
81
505
24
77
3.46
6.45
7.4
4.1
91.47
76.51
ng/l
0.34
24
67
41
188
2.54
5.85
2.2
1.7
1279.07
1160.70
nmol/l
0.37
30
146
78
480
2.13
5.55
3.9
2.3
73.14
74.97
nmol/l
0.22
73
429
8
6
13.88
5.13
2.0
4.7
34.50
26.83
umol/l
—
8
6
67
399
2.10
5.11
4.4
2.9
2.35
2.36
mmol/l
0.14
59
362
83
552
1.96
4.54
4.1
2.7
161.09
123.04
ug/l
0.56
77
510
68
430
1.95
4.25
3.9
3.1
29.70
49.88
ng/l
0.84
49
275
105
769
1.92
4.19
12.4
9.3
3.53
3.94
e9/l
1.42
98
674
60
365
1.98
4.18
2.8
2.3
55.81
69.32
u/l
0.53
53
339
117
890
1.96
4.15
3.5
3.2
42.87
43.18
u/l
0.02
110
840
124
964
2.00
4.10
11.3
6.9
85.07
81.84
u/l
0.28
118
903
69
444
1.92
4.06
2.4
1.8
97.82
98.30
pmol/l
0.03
43
228
77
514
1.89
4.05
12.7
11.7
1.05
1.24
inr
3.56
26
137
68
441
1.89
3.87
3.8
3.1
—
—
—
0
0
52
310
1.97
3.80
5.0
3.6
21.20
6.39
mg/mmol
0.95
35
192
27
129
2.29
3.46
8.3
4.6
5.82
5.83
kpa
0.02
27
124
22
101
2.35
3.09
7.6
5.9
0.09
1.77
mmol/l
1.16
16
78
11
31
3.72
3.05
2.7
5.1
24.38
23.61
mmol/l
0.36
11
31
27
137
2.15
3.00
4.9
5.7
103.93
104.30
mmol/l
0.13
27
137
12
37
3.41
3.00
2.8
1.5
—
—
—
0
0
50
316
1.82
2.99
2.9
3.2
6003.31
1229.73
ng/l
0.58
42
254
10
27
3.86
2.93
1.7
3.6
—
—
—
0
0
5
6
8.53
2.76
1.0
1.2
241.40
261.00
mg/l
—
5
6
9
24
3.89
2.71
1.4
1.5
—
—
—
0
0
82
609
1.66
2.70
3.4
3.1
0.00
0.00
estimate
-0.00
19
119
68
483
1.67
2.65
3.4
3.2
—
—
—
0
0
6
11
5.60
2.56
1.2
1.0
—
—
—
0
0
10
31
3.36
2.56
1.2
1.5
—
—
—
0
0
5
8
6.39
2.38
1.0
1.3
—
—
—
0
0
81
614
1.60
2.38
3.5
3.1
0.00
0.00
estimate
-0.00
19
113
117
969
1.63
2.36
5.1
4.0
12.86
11.21
mm/h
0.57
107
893
80
607
1.59
2.33
4.6
4.2
0.00
0.00
estimate
-0.00
20
111
7
18
4.01
2.27
4.6
2.8
16.21
15.99
%
—
7
7
83
640
1.57
2.23
11.2
6.0
12.85
11.65
umol/l
0.33
76
607
47
316
1.67
2.21
3.9
3.6
0.00
0.00
estimate
-0.00
19
110
21
111
2.01
2.12
4.8
3.3
—
—
—
0
0
46
314
1.63
2.03
1.7
1.4
2.96
1.53
u/ml
0.38
14
76
5
11
4.64
1.95
1.0
1.7
—
—
—
0
0
15
73
2.15
1.87
1.7
1.5
—
—
—
0
0
6
154
0.37
1.87
1.2
1.8
—
—
—
0
0
6
17
3.62
1.85
1.8
1.9
—
—
—
0
0
5
12
4.26
1.83
1.0
1.2
226.80
193.50
mg/l
—
5
12
24
142
1.80
1.76
6.5
6.6
—
—
—
0
0
138
1227
1.60
1.73
4.3
3.6
1.31
1.32
mmol/l
0.04
129
1122
133
1186
1.52
1.52
4.9
4.2
1.78
1.91
mu/l
0.78
121
1084
47
346
1.49
1.47
3.5
2.8
0.22
0.32
e6/l
0.45
41
259
7
28
2.56
1.47
1.0
3.1
34.50
36.03
mg/l
—
7
23
7
28
2.56
1.47
1.0
3.1
56.20
251.95
mg/l
—
7
23
9
39
2.38
1.45
1.0
1.2
—
—
—
0
0
112
973
1.42
1.41
4.4
3.6
15.06
14.67
pmol/l
0.86
105
883
6
23
2.66
1.38
9.0
5.7
48.17
55.70
%
—
6
23
33
228
1.55
1.38
1.5
1.3
20.99
33.01
iu/ml
—
9
78
5
17
3.00
1.37
1.2
1.1
—
—
—
0
0
9
43
2.15
1.32
1.6
1.8
—
—
—
0
0
5
18
2.83
1.29
2.2
1.8
0.35
0.33
nmol/l
—
5
13
147
1355
1.55
1.27
24.6
13.5
3.97
3.96
mmol/l
0.15
142
1317
6
25
2.45
1.25
2.2
1.7
—
—
—
0
0
14
78
1.86
1.25
1.1
1.2
—
—
—
0
0
11
56
2.03
1.25
3.8
3.6
1.16
1.33
%
0.18
11
56
146
1347
1.52
1.22
21.9
12.4
26.45
23.13
mg/l
0.44
118
1036
8
39
2.10
1.17
1.0
1.2
—
—
—
0
0
141
1297
1.46
1.14
5.2
4.3
2.69
2.80
mmol/l
0.66
133
1199
7
30
2.39
1.13
1.7
1.2
—
—
—
0
0
13
74
1.82
1.10
2.2
1.8
—
—
—
0
0
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
30
215
1.48
1.07
1.3
1.2
0.88
2.50
u/ml
—
8
81
9
47
1.96
1.04
1.4
1.6
—
—
—
0
0
138
1274
1.40
1.01
4.8
3.9
1.48
1.44
mmol/l
0.34
130
1177
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
7
36
1.98
0.98
3.0
2.0
—
—
—
0
0
7
36
1.98
0.98
1.6
1.3
—
—
—
0
0
6
27
2.26
0.94
1.5
1.8
—
—
—
0
0
10
55
1.87
0.94
3.5
3.6
0.55
0.65
%
—
10
55
138
1279
1.38
0.94
4.8
3.9
4.65
4.69
mmol/l
0.15
130
1195
9
52
1.77
0.94
3.6
3.4
37.79
51.43
%
—
9
52
8
42
1.95
0.90
1.6
1.5
—
—
—
0
0
24
171
1.47
0.89
4.6
2.3
29.69
29.02
s
0.24
24
166
36
277
1.38
0.89
3.0
1.9
1.56
0.92
mg/l
0.29
28
211
8
43
1.90
0.88
1.1
3.7
—
—
—
0
0
28
208
1.41
0.84
2.6
3.1
9.15
363.43
ng/l
1.58
20
154
9
147
0.59
0.83
1.2
1.8
—
—
—
0
0
6
33
1.85
0.80
2.2
1.6
—
—
—
0
0
22
158
1.45
0.79
4.4
4.1
11.00
8.28
umol/l
0.28
17
135
134
1248
1.32
0.79
5.0
4.0
6.09
5.86
mmol/l
0.98
122
1143
11
171
0.62
0.77
1.4
2.0
—
—
—
0
0
12
76
1.62
0.74
2.2
3.6
187.83
132.51
ng/l
0.22
12
68
5
26
1.95
0.71
1.2
1.3
—
—
—
0
0
126
1171
1.28
0.71
7.3
4.8
40.24
39.25
mmol/mol
0.50
117
1094
5
27
1.88
0.69
1.2
1.3
—
—
—
0
0
5
28
1.81
0.66
1.0
1.3
—
—
—
0
0
5
29
1.74
0.64
2.0
1.7
—
—
—
0
0
8
51
1.60
0.61
1.6
2.2
51.13
38.80
u/l
—
8
46
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
6
37
1.64
0.56
1.8
1.8
—
—
—
0
0
6
37
1.64
0.56
1.8
1.8
—
—
—
0
0
14
99
1.45
0.56
16.1
7.9
23.79
25.39
mmol/l
1.29
14
99
6
39
1.56
0.53
2.8
3.4
5.17
95.91
u/ml
—
6
32
9
65
1.41
0.51
2.9
13.4
22.08
24.65
mmol/l
—
9
60
158
1530
1.36
0.50
30.7
17.7
39.20
40.58
%
1.90
148
1450
33
280
1.22
0.42
1.6
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
65
588
1.17
0.41
4.8
2.5
—
—
—
0
0
0
17
0.00
0.41
0.0
3.4
—
10.72
—
0
6
15
116
1.32
0.38
4.6
10.2
0.35
1.47
mmol/l
—
10
92
50
454
1.14
0.30
3.3
4.2
1.64
2.54
ug/l
0.65
45
404
32
359
0.87
0.26
3.1
3.7
20.27
21.15
%
—
9
156
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
24
210
1.17
0.23
2.3
2.5
1.96
0.93
e6/l
0.33
14
117
123
1191
1.11
0.22
20.9
10.9
84.14
84.23
ml/min/173m2
0.01
108
973
99
949
1.10
0.22
3.0
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
32.98
—
0
13
17
146
1.18
0.20
4.8
3.8
31.18
31.26
%
0.01
11
98
14
118
1.20
0.20
4.4
10.1
12.14
12.20
kpa
0.02
14
113
14
118
1.20
0.20
4.4
10.1
4.82
5.21
kpa
1.04
14
112
6
53
1.14
0.19
8.2
7.9
24.05
24.89
mmol/l
—
6
53
8
68
1.18
0.17
2.1
3.4
4.26
4.57
pmol/l
—
8
59
22
198
1.13
0.15
2.9
2.6
1.58
1.78
e6/l
0.09
12
105
33
308
1.09
0.12
6.3
2.2
—
—
—
0
0
8
77
1.04
0.07
1.0
1.0
—
—
—
0
0
9
84
1.08
0.07
2.4
1.8
—
—
—
0
0
10
89
1.13
0.07
1.2
1.2
91.62
147.75
iu/ml
—
5
36
12
132
0.90
0.07
2.3
1.8
—
—
—
0
0
20
187
1.08
0.06
1.6
1.4
—
—
—
0
0
20
191
1.05
0.03
1.8
1.9
—
—
—
0
0
13
129
1.01
0.00
2.2
1.8
—
—
—
0
0
27
274
0.98
0.00
1.7
2.8
0.52
0.69
ug/l
1.08
15
167
7
72
0.97
0.00
2.1
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
14.00
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
18.72
—
0
6
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.29
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
70
1.00
-0.00
2.9
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.22
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
106.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_CARBO and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_CARBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_CARBO – Other disorders of carbohydrate metabolism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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