Drug-induced myopathy

G6_DRUGMYOP

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G72.0# Cause of death: ICD-10 — G72.0# 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Control exclude: G6_MYONEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G72
Name in latin: Myopathia medicamento provocata

NAME	G6_DRUGMYOP
CONTROL_EXCLUDE	G6_MYONEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G720
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G720
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced myopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1105	444	652
Only index persons	966	397	569
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	64.92	70.20	61.21
Only index persons	64.72	69.67	61.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	39	64
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	61.87	59.54	63.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
93: Matched controls
929

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G72.0

ICD-10 Finland

Drug-induced myopathy

+∞

134.0

G72.8

ICD-10 Finland

Other specified myopathies

+∞

34.5

G72.9

ICD-10 Finland

Myopathy, unspecified

+∞

21.7

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

4.3

9.4

166

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

8.8

8.1

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

9.4

8.0

N17.9

ICD-10 Finland

Acute renal failure, unspecified

12.4

7.6

N05BA01

ATC

diazepam; systemic, rectal

4.8

7.4

N03AG01

ATC

valproic acid; systemic, rectal

7.5

7.4

AA1AD

NOMESCO Finland

CT of head and brain

3.8

7.3

138

C07AB07

ATC

bisoprolol; oral

3.3

7.1

330

N05CF01

ATC

zopiclone; oral

3.4

7.0

179

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.3

6.6

171

G72.1

ICD-10 Finland

Alcoholic myopathy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024561) Albumin [Mass/volume] in Serum or Plasma

343

3.03

6.99

4.6

4.0

34.6

35.7

g/l

0.61

325

(3023368) Bacteria identified in Blood by Culture

229

2.82

6.11

6.8

4.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

139

3.02

5.92

3.2

3.7

0.8

mmol/l

0.63

130

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

300

2.68

5.70

2.4

2.0

87.7

91.3

pmol/l

0.22

153

(3000991) Gas panel - Venous blood

3.57

5.60

8.6

7.4

—

(3032080) INR in Blood by Coagulation assay

356

2.64

5.48

15.1

9.2

1.3

inr

—

(3006315) Basophils [#/volume] in Blood

392

2.56

5.08

8.6

5.8

0.0

e9/l

0.11

350

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

349

2.51

5.00

3.8

3.7

—

(3019198) Lymphocytes [#/volume] in Blood

400

2.48

4.75

8.7

5.9

2.2

1.9

e9/l

0.30

361

(3013115) Eosinophils [#/volume] in Blood

405

2.43

4.55

10.9

6.1

0.2

e9/l

0.18

360

(3044640) Blood type and Crossmatch panel - Blood

258

2.41

4.51

2.7

2.4

—

(3001604) Monocytes [#/volume] in Blood

390

2.38

4.42

8.8

5.7

0.7

0.6

e9/l

1.06

346

(3012544) pH of Venous blood

3.11

4.39

5.4

4.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.65

4.38

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.91

4.22

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.71

4.19

3.1

1.1

—

(3026008) Bacteria identified in Urine by Culture

225

2.37

4.16

3.7

3.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

164

2.49

4.16

2.0

1.7

1337.3

1222.0

nmol/l

0.25

126

(42870588) Differential panel, method unspecified - Blood

268

2.29

4.04

8.8

5.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

264

2.25

3.85

2.4

3.1

2.3

2.4

mmol/l

0.61

228

(46235355) HIV 1 and 2 tests - Meaningful Use set

106

2.65

3.82

1.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

251

2.22

3.70

3.0

3.3

2154.6

1722.2

ng/l

0.34

212

(3037467) Urinalysis macro (dipstick) panel - Urine

519

2.29

3.63

5.4

4.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

457

2.14

3.39

14.5

9.5

4.7

4.2

e9/l

0.89

395

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

2.38

3.35

1.9

1.8

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

392

2.10

3.34

8.7

6.4

1.2

mmol/l

1.24

340

(3006504) Eosinophils/100 leukocytes in Blood

374

2.09

3.32

9.6

5.7

2.6

2.7

0.14

344

(3019069) Monocytes/100 leukocytes in Blood

376

2.07

3.26

10.0

6.0

9.6

8.7

1.02

352

(40758558) Short blood count panel - Blood

190

2.18

3.19

10.8

6.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

426

2.06

3.15

7.8

6.2

13.7

12.1

umol/l

0.19

409

(3018010) Neutrophils/100 leukocytes in Blood

380

2.04

3.12

9.3

5.6

56.3

58.7

0.71

356

(3022096) Basophils/100 leukocytes in Blood

362

2.03

3.11

10.2

5.8

0.6

0.7

0.25

336

(3003181) Sodium [Moles/volume] in Urine

6.17

3.07

1.3

1.6

44.6

51.8

mmol/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.46

3.02

2.2

1.9

1.8

0.03

(3011397) Hemoglobin [Presence] in Urine by Test strip

156

2.20

2.96

4.8

3.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

195

2.11

2.96

2.3

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

342

1.97

2.87

5.5

4.2

66.9

55.3

ng/l

0.19

259

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

300

1.96

2.79

2.4

2.1

76.8

77.1

nmol/l

0.01

262

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

294

1.94

2.70

4.6

3.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

386

1.91

2.65

10.1

6.0

25.8

26.3

0.12

359

(3027944) Amphetamines [Presence] in Urine

4.92

2.64

8.6

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

4.92

2.64

8.6

1.7

—

(3011288) Drugs identified in Urine by Screen method

5.71

2.58

9.3

1.7

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

7.43

2.57

1.0

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.33

2.52

1.7

—

(3028300) Cannabinoids [Presence] in Urine

4.61

2.52

8.6

1.6

—

(3016879) Cocaine [Presence] in Urine

4.61

2.52

8.4

1.6

—

(3027008) Opiates [Presence] in Urine

4.61

2.52

8.6

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

174

2.02

2.49

2.2

1.7

3.6

1.3

mg/l

0.63

142

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

623

2.04

2.47

9.6

7.3

80.6

79.3

u/l

0.08

582

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.06

2.38

6.8

7.0

—

(3015736) pH of Urine

288

1.85

2.32

5.6

3.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.83

2.30

4.7

1.5

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.83

2.30

1.2

1.0

—

(3018418) pH of Serum or Plasma

237

1.88

2.29

5.3

3.4

7.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.27

2.28

1.8

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

238

1.87

2.25

4.7

3.2

7.4

8.0

mmol/l

0.29

205

(3028707) Methadone [Presence] in Urine by Screen method

5.77

2.24

6.2

1.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

118

2.10

2.23

2.5

2.1

23.2

21.3

0.18

106

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

197

1.91

2.22

2.8

1.8

3.7

3.1

mg/l

0.63

173

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.08

2.13

1.2

1.7

—

(40768797) Stomach Pathology biopsy report

106

2.10

2.09

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.21

1.98

1.9

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.71

1.96

1.4

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.56

1.92

1.7

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.43

1.89

1.2

2.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

574

1.76

1.88

5.9

4.1

13.9

12.5

mm/h

0.39

528

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

134

1.92

1.86

4.6

2.6

4.2

2.4

e6/l

0.28

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.47

1.77

1.2

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.75

0.0

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

211

1.75

3.2

2.5

388.4

8796.0

umol/l

1.23

173

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.26

1.74

2.8

219.0

155.9

ng/l

0.36

(3042936) Bacteria identified in Isolate by Culture

115

1.92

1.67

3.1

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

533

1.66

1.65

4.5

3.1

94.4

52.4

u/l

1.01

499

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.70

1.63

3.0

3.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.70

1.63

1.0

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.12

1.60

1.0

1.3

—

(1616796) Gas panel - Central venous blood

3.45

1.54

2.2

2.9

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.97

1.53

1.3

1.8

0.0

g/l

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.20

1.44

3.4

2.8

195.5

71.0

ng/l

1.04

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.51

1.42

1.3

1.8

2.5

3.1

g/l

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.70

1.39

1.0

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

3.04

1.37

1.2

1.5

—

(3024928) Oxygen saturation in Venous blood

3.04

1.37

2.8

2.1

—

(3027315) Oxygen [Partial pressure] in Blood

3.04

1.37

2.6

2.5

8.3

7.6

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.04

1.37

2.6

2.5

4.8

kpa

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.86

1.30

1.4

1.3

—

(3021901) Oxygen saturation in Capillary blood

2.86

1.30

3.8

2.2

—

(40761535) Cells panel - Urine sediment

2.08

1.27

4.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

367

1.52

1.24

6.3

5.4

0.0

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

790

1.78

1.24

29.8

15.0

27.0

23.8

mg/l

0.44

633

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

177

1.63

1.24

1.6

1.7

570.2

463.8

pmol/l

0.50

151

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.71

1.23

1.2

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.71

1.23

1.2

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

103

1.78

1.22

13.6

8.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

692

1.61

1.21

5.7

4.5

1.8

2.0

mu/l

0.82

619

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.82

1.19

1.6

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

145

1.66

1.18

4.5

2.4

0.8

0.9

e6/l

0.02

(3019060) Gas panel - Arterial blood

2.00

1.17

2.6

3.7

—

(3034770) Mitochondria Ab [Titer] in Serum

2.45

1.10

1.0

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.34

1.04

2.0

—

(3020891) Body temperature

2.07

1.02

4.6

4.1

—

(1761868) Lipid panel - Serum or Plasma

273

0.63

1.02

4.6

2.9

—

(3021589) Normoblasts [#/volume] in Blood

332

1.45

1.00

13.5

10.2

0.0

e9/l

0.62

280

(3022313) Gas panel - Capillary blood

1.96

0.96

2.7

2.9

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.30

0.95

1.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.21

0.93

1.3

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.98

0.91

4.8

2.9

0.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.93

0.90

4.8

2.9

1.5

1.2

—

(3012516) Albumin [Mass/volume] in Urine

229

1.44

0.85

3.8

3.4

29.1

319.4

mg/l

0.58

157

(3002256) Pathology report gross observation

1.62

0.84

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.70

0.82

2.0

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.72

0.81

1.8

1.4

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.80

0.0

1.3

—

3.9

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.80

0.0

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

169

1.46

0.78

1.6

1.2

2.3

2.4

u/ml

—

(3044889) 12 lead EKG panel

541

1.37

0.78

4.7

4.0

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.23

0.77

1.6

2.8

27.9

319.2

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.23

0.77

1.6

2.8

22.9

25.3

mg/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

253

1.38

0.74

4.6

4.0

2.3

8.7

mg/mmol

2.15

163

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.89

0.69

1.2

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

1.82

0.67

2.0

3.5

—

(40761511) CBC panel - Blood by Automated count

814

1.44

0.62

26.1

14.4

—

(36660697) Celiac disease serology panel - Serum

1.55

0.60

1.5

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.59

0.0

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.57

0.59

3.4

2.2

404.0

365.1

nmol/l

0.22

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

211

0.71

0.54

1.9

2.9

1.0

0.9

ug/l

—

137

(40768804) Tissue Pathology biopsy report

306

1.27

0.49

2.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

675

1.28

0.49

36.2

15.6

37.0

40.6

1.80

485

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.49

0.48

13.1

6.0

26.4

24.5

mmol/l

—

(3019225) pH of Specimen

1.45

0.47

5.2

4.5

—

(3013512) EKG study

270

1.27

0.46

6.2

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

291

1.25

0.44

4.6

4.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

169

1.30

0.43

5.7

5.0

—

(3000850) Epithelial cells [#/volume] in Urine

188

1.29

0.42

4.0

2.4

5.8

4.8

e6/l

0.19

165

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.3

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.41

0.0

1.3

—

9646.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.3

—

6.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.49

0.41

2.0

1.8

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.40

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.42

0.35

1.5

—

(3003694) ABO and Rh group [Type] in Blood

184

1.25

0.34

1.2

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

760

1.24

0.34

5.6

4.8

6.2

6.0

mmol/l

0.49

689

(3022621) pH of Urine by Test strip

1.37

0.32

3.0

2.3

—

(36304419) Bacteria [Presence] in Urine

233

1.22

0.32

5.3

2.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

837

1.25

0.30

33.9

18.0

87.1

81.6

umol/l

0.47

837

(3007164) IgA [Mass/volume] in Serum or Plasma

151

1.23

0.27

1.6

1.3

2.8

2.5

g/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.37

0.24

2.0

2.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.28

0.23

4.6

3.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.33

0.23

2.0

2.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.33

0.23

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.30

0.23

1.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.23

0.22

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

3.0

—

(4268621)

0.00

0.21

0.0

2.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3021788) Differential panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(4306422)

0.00

0.20

0.0

1.3

—

(3000492) Spirometry study

1.14

0.16

1.8

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

419

1.09

0.12

3.5

2.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

279

0.91

0.11

3.0

4.5

25.0

20.9

0.52

141

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.08

1.7

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.08

3.3

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.82

0.08

2.0

1.4

—

(4035726)

1.10

0.08

1.4

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

219

1.06

0.05

3.8

3.6

—

(3022145) Colonoscopy Study observation

1.11

0.04

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

770

1.05

0.04

5.4

4.1

1.4

1.3

mmol/l

1.07

700

(3000494) Fungus identified in Specimen by Culture

102

1.09

0.03

1.2

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

751

1.05

0.03

29.1

13.8

79.1

79.0

ml/min/173m2

0.01

617

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

356

0.97

0.00

4.0

5.1

1.7

2.6

ug/l

0.77

314

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

103

0.97

0.00

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

786

1.02

0.00

5.6

4.6

1.4

1.5

mmol/l

1.20

715

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

789

1.01

0.00

5.5

4.6

4.4

4.5

mmol/l

0.93

723

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

31.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.92

0.00

2.2

1.7

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(4024509)

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3048879) Bone marrow aspiration report

0.00

0.0

3.8

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

16.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

22.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(4010399)

1.00

0.00

1.5

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.96

0.00

1.4

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

2.4

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.5

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.5

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

6.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.4

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

4.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.2

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

1.7

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.8

—

3.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.7

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

4.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.8

—

12.8

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(4281824)

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DRUGMYOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	2.524 [1.94, 3.28]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.681

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 406 females with G6_DRUGMYOP died.

Males

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	3.526 [2.43, 5.11]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 603 males with G6_DRUGMYOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_DRUGMYOP.

N-year risk	Females	Males
1	0.338%	0.656%
5	1.617%	3.793%
10	4.124%	9.144%
15	7.844%	16.717%
20	13.534%	27.041%

Relationships between endpoints

↥

Index endpoint: G6_DRUGMYOP – Drug-induced myopathy

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced myopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints