Drug-induced myopathy

G6_DRUGMYOP

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G72.0# Cause of death: ICD-10 — G72.0# 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	100

Control definitions (FinnGen only)

Control exclude: G6_MYONEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G72
Name in latin: Myopathia medicamento provocata

NAME	G6_DRUGMYOP
CONTROL_EXCLUDE	G6_MYONEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G720
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G720
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced myopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1105	444	652
Only index persons	966	397	569
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	64.92	70.20	61.21
Only index persons	64.72	69.67	61.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	100	39	61
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	61.85	59.54	63.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
103: Matched controls
1030

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G72.0

ICD-10 Finland

Drug-induced myopathy

+∞

148.5

103

G72.8

ICD-10 Finland

Other specified myopathies

+∞

40.3

G72.9

ICD-10 Finland

Myopathy, unspecified

+∞

26.2

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

6.7

11.2

N05BA01

ATC

diazepam; systemic, rectal

4.6

9.6

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.6

9.5

226

A06AD11

ATC

lactulose; oral

3.8

8.0

100

N03AG01

ATC

valproic acid; systemic, rectal

8.3

7.9

AA1AD

NOMESCO Finland

CT of head and brain

3.3

7.8

191

ZXD05

NOMESCO Finland

Urgent procedure

3.1

7.0

187

N17.9

ICD-10 Finland

Acute renal failure, unspecified

7.9

6.5

XF400

NOMESCO Finland

ECG with 12 standard connections

3.2

6.4

127

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.2

6.4

134

G72

ICD-10 Finland

Other myopathies

+∞

6.3

G72.1

ICD-10 Finland

Alcoholic myopathy

+∞

6.3

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

4.4

6.3

T36

ICD-10 Finland

Poisoning by systemic antibiotics

11.0

6.2

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.9

6.1

200

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024561) Albumin [Mass/volume] in Serum or Plasma

340

2.95

6.69

4.7

4.0

34.54

35.71

g/l

0.67

323

(3022217) INR in Platelet poor plasma by Coagulation assay

414

3.02

6.56

21.2

17.3

1.34

1.33

inr

0.02

111

(3012095) Magnesium [Moles/volume] in Serum or Plasma

140

3.00

5.84

3.2

3.7

0.79

0.83

mmol/l

0.73

132

(3000991) Gas panel - Venous blood

3.57

5.60

8.6

7.4

—

(3023368) Bacteria identified in Blood by Culture

231

2.68

5.53

6.9

4.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

297

2.62

5.43

2.4

2.0

87.01

91.62

pmol/l

0.28

149

(3006315) Basophils [#/volume] in Blood

392

2.46

4.70

8.7

5.7

0.04

e9/l

0.14

350

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.82

4.67

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

352

2.39

4.49

2.6

2.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

160

2.56

4.40

2.0

1.7

1337.34

1229.23

nmol/l

0.23

124

(3019198) Lymphocytes [#/volume] in Blood

401

2.37

4.35

8.8

5.8

2.18

1.85

e9/l

0.34

364

(3007853) Bacteria identified in Skin by Aerobe culture

2.94

4.31

1.7

—

(3013115) Eosinophils [#/volume] in Blood

405

2.33

4.20

11.1

6.0

0.20

0.19

e9/l

0.16

360

(3044640) Blood type and Crossmatch panel - Blood

259

2.31

4.08

2.7

2.4

—

(3001604) Monocytes [#/volume] in Blood

391

2.28

4.03

8.9

5.7

0.74

0.58

e9/l

1.10

348

(3015377) Calcium [Moles/volume] in Serum or Plasma

261

2.29

3.99

2.4

3.2

2.32

2.35

mmol/l

0.57

229

(3014576) Chloride [Moles/volume] in Serum or Plasma

104

2.70

3.97

6.8

5.8

103.38

103.62

mmol/l

0.08

104

(46235355) HIV 1 and 2 tests - Meaningful Use set

107

2.62

3.75

1.7

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

373

2.18

3.68

9.2

6.2

—

(3026008) Bacteria identified in Urine by Culture

228

2.23

3.63

3.7

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

521

2.27

3.56

5.3

4.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

248

2.17

3.47

3.0

3.3

2175.03

1735.12

ng/l

0.33

210

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.50

3.29

3.1

1.1

—

(40758558) Short blood count panel - Blood

188

2.21

3.28

10.8

6.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

425

2.07

3.18

7.8

6.2

13.72

12.02

umol/l

0.20

408

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

137

2.32

3.18

1.9

1.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

298

2.06

3.17

2.4

2.1

76.30

77.00

nmol/l

0.04

260

(3027945) Reticulocytes/100 erythrocytes in Blood

2.52

3.16

2.2

1.9

1.79

1.75

0.06

(3003181) Sodium [Moles/volume] in Urine

6.17

3.07

1.3

1.6

44.57

51.75

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

458

2.05

3.06

14.7

9.5

4.67

4.15

e9/l

1.02

394

(3006504) Eosinophils/100 leukocytes in Blood

375

2.00

2.99

9.8

5.7

2.63

2.77

0.20

346

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

395

1.99

2.94

8.7

6.4

1.19

1.21

mmol/l

1.28

344

(3019069) Monocytes/100 leukocytes in Blood

377

1.98

2.92

10.2

5.9

9.57

8.69

1.02

353

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

196

2.10

2.91

2.3

2.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

158

2.16

2.86

4.8

3.9

—

(3018010) Neutrophils/100 leukocytes in Blood

381

1.95

2.80

9.5

5.6

56.15

58.63

0.73

359

(3022096) Basophils/100 leukocytes in Blood

363

1.95

2.78

10.3

5.7

0.61

0.66

0.20

337

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

340

1.91

2.65

5.5

4.2

67.94

55.23

ng/l

0.20

259

(3000764) Benzodiazepines [Presence] in Urine

4.92

2.64

8.6

1.7

—

(3027944) Amphetamines [Presence] in Urine

4.92

2.64

8.6

1.6

—

(3011288) Drugs identified in Urine by Screen method

5.71

2.58

9.3

1.7

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

7.43

2.57

1.0

1.1

—

(3027008) Opiates [Presence] in Urine

4.61

2.52

8.6

1.6

—

(3016879) Cocaine [Presence] in Urine

4.61

2.52

8.4

1.6

—

(3028300) Cannabinoids [Presence] in Urine

4.61

2.52

8.6

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

174

2.02

2.49

2.2

1.7

3.63

1.26

mg/l

0.63

143

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.31

2.46

1.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

387

1.83

2.35

10.2

5.9

25.85

26.25

0.10

362

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

296

1.85

2.34

4.6

3.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.83

2.30

1.2

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.83

2.30

4.7

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

237

1.88

2.29

4.7

3.2

7.86

7.93

mmol/l

0.03

204

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.05

2.28

6.8

7.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

196

1.92

2.26

2.7

1.8

3.71

3.10

mg/l

0.59

171

(40768797) Stomach Pathology biopsy report

103

2.17

2.24

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

5.77

2.24

6.2

1.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

118

2.10

2.23

2.5

2.0

23.24

21.44

0.17

106

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

623

1.93

2.21

9.6

7.3

80.83

78.62

u/l

0.15

582

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.21

2.16

1.8

1.7

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.08

2.13

1.2

1.7

—

(3018418) pH of Serum or Plasma

242

1.83

2.12

5.3

3.4

7.39

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.21

1.98

1.9

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.71

1.96

1.4

1.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

573

1.77

1.90

5.9

4.1

14.02

12.51

mm/h

0.44

526

(3004588) Protein electrophoresis panel - Serum or Plasma

2.43

1.89

1.2

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.50

1.85

1.7

1.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

209

1.77

1.81

3.2

2.5

388.44

8746.95

umol/l

1.23

174

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.75

0.0

1.5

—

(3023183) Ammonium ion [Moles/volume] in Plasma

3.05

1.75

1.9

3.6

29.29

35.11

umol/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.26

1.74

2.8

219.00

155.91

ng/l

0.36

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.98

1.73

1.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

114

1.94

1.72

3.1

2.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.29

1.68

1.2

1.4

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.70

1.63

3.0

3.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

535

1.65

1.61

4.4

3.1

94.57

52.15

u/l

1.03

501

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.12

1.60

1.0

1.3

—

(1616796) Gas panel - Central venous blood

3.45

1.54

2.2

2.9

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.97

1.53

1.3

1.8

0.00

g/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

135

1.80

1.51

4.7

2.5

4.55

2.49

e6/l

0.30

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.83

1.45

1.0

1.3

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.20

1.44

3.4

2.8

195.45

70.99

ng/l

1.04

(3013290) Carbon dioxide [Partial pressure] in Blood

3.04

1.37

2.6

2.5

4.78

4.77

kpa

—

(3021901) Oxygen saturation in Capillary blood

3.04

1.37

3.8

2.2

—

(3027315) Oxygen [Partial pressure] in Blood

3.04

1.37

2.6

2.5

8.28

7.58

kpa

—

(3024928) Oxygen saturation in Venous blood

2.86

1.30

2.8

2.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.86

1.30

1.4

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.86

1.30

1.2

1.7

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.86

1.30

1.2

1.7

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

175

1.65

1.30

1.6

1.8

570.16

465.88

pmol/l

0.49

151

(40761535) Cells panel - Urine sediment

2.08

1.27

3.9

4.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

102

1.80

1.26

13.6

8.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

368

1.51

1.22

5.9

5.4

0.00

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

791

1.77

1.22

29.7

15.0

26.61

23.67

mg/l

0.39

635

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.39

1.20

1.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.39

1.20

1.3

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.82

1.19

1.6

1.5

—

(3019060) Gas panel - Arterial blood

2.00

1.17

2.6

3.7

—

(3034770) Mitochondria Ab [Titer] in Serum

2.57

1.16

1.0

1.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

695

1.59

1.15

5.7

4.5

1.79

1.96

mu/l

0.70

623

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.34

1.04

2.0

—

(1761868) Lipid panel - Serum or Plasma

274

0.62

1.04

4.1

2.9

—

(3020891) Body temperature

2.07

1.02

4.6

4.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

168

1.56

1.02

1.5

1.2

2.30

2.39

u/ml

—

(3022313) Gas panel - Capillary blood

2.01

0.99

2.7

2.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

146

1.55

0.92

4.6

2.4

0.88

0.82

e6/l

0.05

(3002256) Pathology report gross observation

1.64

0.87

1.3

—

(3012516) Albumin [Mass/volume] in Urine

228

1.45

0.87

3.8

3.4

29.15

321.55

mg/l

0.58

156

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.73

0.86

2.0

1.5

—

(3021589) Normoblasts [#/volume] in Blood

333

1.38

0.81

13.5

10.1

0.00

e9/l

0.62

280

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.80

0.0

1.3

—

3.86

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.79

0.0

1.7

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.23

0.77

1.6

2.8

22.90

25.34

mg/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.23

0.77

1.6

2.8

27.92

319.24

mg/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

252

1.39

0.76

4.4

3.9

2.30

8.77

mg/mmol

2.16

162

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.97

0.71

1.2

1.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.67

0.68

5.3

2.9

0.73

0.72

—

(3052851) Hemolysis interference index of Serum or Plasma

1.82

0.67

2.0

3.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.63

0.66

5.3

2.9

1.54

1.15

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.68

0.64

1.8

1.4

—

(40761511) CBC panel - Blood by Automated count

813

1.45

0.64

25.9

14.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.59

0.62

3.4

2.2

404.00

362.93

nmol/l

0.24

(36660697) Celiac disease serology panel - Serum

1.58

0.61

1.5

1.2

—

(3044889) 12 lead EKG panel

543

1.30

0.61

4.8

4.0

—

(3008898) HLA-B27 [Presence]

0.00

0.59

0.0

1.0

—

(3019225) pH of Specimen

1.49

0.52

5.2

4.5

—

(40768804) Tissue Pathology biopsy report

307

1.27

0.48

2.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.49

0.48

13.1

6.0

26.39

24.64

mmol/l

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

206

0.74

0.47

1.9

2.9

1.00

0.91

ug/l

—

134

(3000850) Epithelial cells [#/volume] in Urine

188

1.29

0.42

4.0

2.4

5.80

4.74

e6/l

0.20

166

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.3

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.41

0.0

1.3

—

9646.44

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.41

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.2

—

6.00

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.45

0.40

2.0

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

294

1.23

0.40

4.4

4.1

—

(3013512) EKG study

268

1.22

0.36

6.1

4.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.42

0.35

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

760

1.24

0.34

5.6

4.7

6.19

5.99

mmol/l

0.54

691

(3022621) pH of Urine by Test strip

1.32

0.31

3.0

2.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

836

1.26

0.31

33.7

18.0

87.14

81.42

umol/l

0.49

836

(3007164) IgA [Mass/volume] in Serum or Plasma

149

1.25

0.30

1.6

1.3

2.76

2.36

g/l

—

(36304419) Bacteria [Presence] in Urine

236

1.20

0.28

5.3

2.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.37

0.24

1.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.28

0.23

4.6

3.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.33

0.23

2.0

2.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.30

0.23

2.0

2.4

—

(3003694) ABO and Rh group [Type] in Blood

183

1.19

0.22

1.2

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.23

0.22

1.2

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.21

0.0

2.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

3.04

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.1

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3021788) Differential panel - Synovial fluid

0.00

0.21

0.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

870

1.17

0.15

44.4

22.0

38.55

40.59

2.36

824

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.08

1.7

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.10

0.08

3.3

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.81

0.08

2.0

1.4

—

(4035726) Immunohistochemistry procedure

1.10

0.08

1.4

1.3

—

(3000492) Spirometry study

1.09

0.08

1.7

1.4

—

(3022145) Colonoscopy Study observation

1.14

0.07

1.4

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

273

0.94

0.06

3.0

4.5

24.99

20.95

0.51

138

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

768

1.06

0.05

5.4

4.1

1.42

1.26

mmol/l

1.09

700

(3000494) Fungus identified in Specimen by Culture

101

1.10

0.04

1.2

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

750

1.05

0.03

29.0

13.9

79.08

79.21

ml/min/173m2

0.02

618

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

350

0.96

0.03

3.9

5.0

1.75

2.58

ug/l

0.72

309

(3041096) Erythrocytes [Presence] in Urine by Automated

221

1.05

0.03

3.4

3.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

421

1.04

0.02

3.6

2.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

784

1.03

0.00

5.6

4.6

1.36

1.46

mmol/l

1.25

716

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

102

0.98

0.00

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

787

1.02

0.00

5.5

4.6

4.40

4.56

mmol/l

0.75

724

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.02

0.00

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.92

0.00

2.2

1.7

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.6

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.4

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.2

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

3.0

—

3.28

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

2.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.6

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.8

—

12.80

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

4.26

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.8

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.4

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.52

—

(3048879) Bone marrow aspiration report

0.00

-0.00

0.0

3.8

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

1.07

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

16.36

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.6

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

1.7

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.1

—

(4200892) Spirometry reversibility

1.02

-0.00

1.5

1.3

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

31.04

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

22.06

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

6.02

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

2.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DRUGMYOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	2.524 [1.94, 3.28]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.681

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 406 females with G6_DRUGMYOP died.

Males

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	3.526 [2.43, 5.11]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 603 males with G6_DRUGMYOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_DRUGMYOP.

N-year risk	Females	Males
1	0.338%	0.656%
5	1.617%	3.793%
10	4.124%	9.144%
15	7.844%	16.717%
20	13.534%	27.041%

Relationships between endpoints

↥

Index endpoint: G6_DRUGMYOP – Drug-induced myopathy

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced myopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints