Pneumoconiosis due to other inorganic dusts

J10_INORGPNEUMOC

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J63 Hospital discharge: ICD-9 — 503 Hospital discharge: ICD-8 — 51600 Cause of death: ICD-10 — J63 Cause of death: ICD-9 — 503 Cause of death: ICD-8 — 51600 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	129

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Pneumoconiosis ex aliis pulveribus inorganicis

NAME	J10_INORGPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J63
HD_ICD_9	503
HD_ICD_8	51600
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J63
COD_ICD_9	503
COD_ICD_8	51600
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to other inorganic dusts based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1874	796	1036
Only index persons	1034	447	587
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	72.58	76.03	69.86
Only index persons	68.26	72.40	65.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	129	38	91
Unadjusted period prevalence (%)	0.03	0.01	0.04
Median age at first event (years)	68.45	65.91	69.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
134: Matched controls
1340

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J63.3

ICD-10 Finland

Graphite fibrosis (of lung)

+∞

53.8

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

15.5

46.9

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

11.4

44.4

102

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

6.9

27.5

157

J63.8

ICD-10 Finland

Pneumoconiosis due to other specified inorganic dusts

+∞

24.7

J63.4

ICD-10 Finland

Siderosis

+∞

22.5

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

5.6

15.0

B01AC07

ATC

dipyridamole; systemic

4.6

11.4

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

118.9

10.6

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

8.4

9.7

J63.1

ICD-10 Finland

Bauxite fibrosis (of lung)

+∞

9.5

J63.0

ICD-10 Finland

Aluminosis (of lung)

+∞

8.4

AA1AD

NOMESCO Finland

CT of head and brain

2.9

7.9

283

B01AC04

ATC

clopidogrel; oral

2.9

7.6

208

51600

ICD-8 Finland

Other pneumoconiosis and related diseases, Due to inhalation of other inorganic dust

+∞

7.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.7

7.2

357

K90

ICPC

Stroke/cerebrovascular accident

6.6

6.5

I63.1

ICD-10 Finland

Cerebral infarction due to embolism of precerebral arteries

8.9

6.5

J63.5

ICD-10 Finland

Stannosis

+∞

6.3

5030A

ICD-9 Finland

Pneumoconiosis due to other inorganic dust[PNEUMOCONIOSIS ALIA DEFINITA]

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.14

3.41

4.8

6.0

25.88

24.48

mmol/l

0.73

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.69

3.29

1.9

1.7

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

6.64

3.22

2.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.11

2.70

10.7

8.8

—

(3000494) Fungus identified in Specimen by Culture

2.16

2.12

2.4

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

356

0.51

2.10

5.6

4.7

23.34

21.85

—

179

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.76

1.90

1.1

1.4

—

(3026361) Erythrocytes [#/volume] in Blood

883

0.64

1.75

44.8

26.1

4.35

4.36

e12/l

0.06

849

(3035941) MCH [Entitic mass]

883

0.64

1.75

44.5

26.0

30.32

30.45

0.24

863

(3024731) MCV [Entitic volume]

882

0.64

1.73

44.5

26.1

92.39

91.75

0.48

862

(3007461) Platelets [#/volume] in Blood

881

0.64

1.71

44.6

26.1

238.99

236.22

e9/l

0.14

852

(40760888) Immunoglobulin light chains.free panel - Serum

3.25

1.68

1.2

4.2

—

(3000991) Gas panel - Venous blood

2.05

1.55

9.1

7.4

—

(40761511) CBC panel - Blood by Automated count

818

0.68

1.41

29.9

17.7

—

(3020891) Body temperature

2.28

1.40

1.4

3.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

122

1.75

1.37

6.7

7.1

104.65

103.22

mmol/l

0.66

122

(3049717) Cytology report of Urine Cyto stain

2.17

1.31

2.0

2.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.46

1.26

2.2

3.2

5.22

5.19

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.46

1.26

2.2

3.2

7.28

7.93

kpa

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.17

1.20

1.9

3.8

24.36

23.58

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

111

1.72

1.19

3.7

2.0

—

(3017732) Neutrophils [#/volume] in Blood

1.98

1.16

5.5

3.0

3.39

3.53

e9/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.90

1.13

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

113

1.68

1.12

10.2

9.6

—

(3003338) MCHC [Mass/volume]

623

0.71

1.12

36.4

24.3

327.86

331.28

g/l

1.41

617

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.33

1.12

1.0

3.5

52.69

39.48

mg/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.33

1.12

1.0

3.5

45.46

70.52

mg/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.01

1.11

2.6

1.6

—

(3025941) Bacteria identified in Stool by Culture

2.02

1.06

1.6

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.32

1.04

1.6

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

757

0.73

1.03

8.5

6.7

44.35

41.60

mmol/mol

0.93

687

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

448

1.39

1.03

9.2

7.1

1.21

mmol/l

0.12

374

(36304419) Bacteria [Presence] in Urine

245

1.46

1.03

4.6

3.0

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.86

0.99

2.4

2.6

9.42

10.35

g/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.78

0.96

1.3

2.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

249

1.43

0.94

2.1

1.8

1340.84

1187.35

nmol/l

0.56

189

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

748

0.75

0.90

30.0

17.3

71.59

71.33

ml/min/173m2

0.03

613

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

844

0.75

0.88

15.4

10.8

22.19

22.68

u/l

0.18

802

(3020564) Creatinine [Moles/volume] in Serum or Plasma

853

0.75

0.87

32.3

21.4

90.04

87.30

umol/l

0.15

853

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

271

1.39

0.87

2.7

2.3

60.31

54.53

u/l

0.35

249

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

431

1.34

0.85

5.2

4.8

31.65

58.67

ng/l

1.48

337

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.79

0.84

2.9

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

338

1.35

0.82

4.7

3.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

791

0.76

0.82

5.9

5.2

2.17

2.46

mmol/l

2.17

701

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.79

0.0

2.7

—

(1616796) Gas panel - Central venous blood

2.22

0.77

2.6

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

178

1.42

0.75

2.9

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.71

3.1

1.8

—

(3037756) Immunofixation for Serum or Plasma

1.96

0.71

1.4

1.3

—

(40761535) Cells panel - Urine sediment

1.61

0.71

6.1

4.1

—

(3023368) Bacteria identified in Blood by Culture

327

1.32

0.70

7.5

4.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

128

1.47

0.70

1.2

1.5

2.77

2.83

g/l

0.03

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.55

0.70

4.8

2.2

4.10

10.64

umol/l

2.20

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

762

0.78

0.69

5.1

4.6

3.89

4.28

mmol/l

2.82

682

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

780

0.79

0.67

5.8

5.1

6.48

6.14

mmol/l

0.62

681

(3022217) INR in Platelet poor plasma by Coagulation assay

482

1.28

0.67

32.2

19.9

1.56

1.37

inr

0.57

143

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

756

0.80

0.62

5.2

4.6

1.28

1.41

mmol/l

2.24

668

(3029937) Albumin [Presence] in Urine by Test strip

243

1.30

0.56

7.4

4.5

0.00

estimate

-0.00

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

356

1.26

0.56

3.2

3.6

2884.89

2064.96

ng/l

0.41

297

(3019060) Gas panel - Arterial blood

1.49

0.54

2.7

3.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.41

0.52

1.8

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

577

0.81

0.51

4.8

3.5

15.25

15.09

pmol/l

0.16

499

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.40

0.42

1.8

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.41

0.0

1.3

—

54318.00

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.44

0.39

4.4

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.37

0.39

1.6

1.4

—

(40768797) Stomach Pathology biopsy report

114

0.68

0.39

2.0

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

293

1.21

0.39

4.7

3.2

70.18

296.41

e6/l

0.50

227

(3005322) IgE [Units/volume] in Serum or Plasma

1.40

0.38

1.4

1.1

15.18

133.95

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

146

0.73

0.38

4.4

3.0

1.40

2.55

e6/l

—

(4200892) Spirometry reversibility

1.33

0.38

1.8

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.33

0.38

10.1

3.2

2.38

1.68

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

733

0.85

0.36

4.5

4.1

1.30

1.23

mmol/l

0.51

643

(36660697) Celiac disease serology panel - Serum

1.45

0.36

1.3

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.40

0.35

7.7

3.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

118

1.31

0.35

3.2

4.2

225.33

248.39

u/l

0.58

109

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

192

1.24

0.35

6.7

3.5

172.87

239.52

ng/l

0.15

169

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.38

0.35

1.0

2.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

137

1.28

0.34

1.3

1.1

7.66

1.12

u/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

355

1.18

0.33

2.8

2.4

—

(3027945) Reticulocytes/100 erythrocytes in Blood

147

1.26

0.33

4.9

3.1

1.70

1.74

0.08

128

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.29

0.32

3.0

2.6

—

(3042936) Bacteria identified in Isolate by Culture

129

1.27

0.32

2.1

2.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

232

1.21

0.32

4.2

2.9

355.00

3764.52

umol/l

0.81

184

(3022313) Gas panel - Capillary blood

1.34

0.31

11.7

3.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

387

1.16

0.30

2.5

2.2

115.62

90.67

pmol/l

1.30

194

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

226

0.81

0.30

2.2

2.8

26.00

33.44

u/l

1.33

215

(3011397) Hemoglobin [Presence] in Urine by Test strip

177

1.22

0.30

6.2

4.6

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

272

1.18

0.29

2.5

2.2

3.98

3.17

mg/l

1.23

235

(3012516) Albumin [Mass/volume] in Urine

263

1.18

0.29

3.5

3.3

1961.65

529.00

mg/l

0.35

176

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

187

1.21

0.29

2.2

1.8

0.74

1.68

mg/l

2.39

149

(3044889) 12 lead EKG panel

583

0.88

0.27

5.4

4.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

333

1.15

0.26

6.5

4.4

—

(4035726) Immunohistochemistry procedure

0.72

0.25

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.36

0.24

1.4

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

6.2

2.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

116

1.23

0.23

2.9

1.8

—

(3003694) ABO and Rh group [Type] in Blood

188

0.83

0.23

1.4

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.25

0.22

1.2

1.3

103.41

45.01

iu/ml

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

117

1.22

0.21

2.9

1.8

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

7.7

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

2.2

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

2.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.3

—

76.13

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

5.0

—

(3019225) pH of Specimen

1.23

0.20

14.7

4.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.20

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.16

0.19

6.8

1.6

1.82

1.68

—

(3041096) Erythrocytes [Presence] in Urine by Automated

236

0.87

0.18

5.7

3.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

410

1.11

0.18

5.5

4.7

32.49

34.54

g/l

1.25

382

(40758558) Short blood count panel - Blood

196

1.15

0.18

7.0

6.9

—

(3009508) Creatinine [Moles/volume] in Urine

265

1.12

0.16

3.4

3.1

6.98

7.10

mmol/l

0.04

214

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.13

0.16

4.6

4.0

1.20

1.22

mmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.22

0.16

1.7

1.5

—

(40768804) Tissue Pathology biopsy report

325

0.90

0.15

2.1

—

(3002256) Pathology report gross observation

100

0.79

0.14

1.3

—

(3022096) Basophils/100 leukocytes in Blood

373

0.92

0.13

12.5

5.6

0.55

0.56

0.04

345

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

1.17

0.13

7.3

3.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

387

1.09

0.12

9.8

5.8

—

(3044640) Blood type and Crossmatch panel - Blood

291

0.91

0.12

3.6

2.7

—

(3018095) Leukocytes [#/volume] in Urine

331

1.08

0.10

5.2

3.7

32.62

54.77

e6/l

0.57

252

(3000492) Spirometry study

1.12

0.09

1.8

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.12

0.09

1.2

1.8

—

(3018010) Neutrophils/100 leukocytes in Blood

378

0.93

0.09

10.1

5.6

62.50

59.03

0.89

354

(1761868) Lipid panel - Serum or Plasma

195

0.91

0.08

1.8

3.5

—

(3018418) pH of Serum or Plasma

254

1.08

0.08

3.0

4.1

7.41

7.40

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.79

0.08

1.2

2.9

—

62.96

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.08

0.08

2.6

1.3

—

(3006504) Eosinophils/100 leukocytes in Blood

376

0.94

0.07

12.3

5.7

2.32

2.77

0.82

349

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.86

0.07

4.6

2.8

198.75

211.70

ng/l

—

(3013512) EKG study

294

0.94

0.06

5.0

4.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

192

0.93

0.06

2.4

3.1

2.44

2.46

mmol/l

0.39

167

(3037467) Urinalysis macro (dipstick) panel - Urine

594

0.96

0.05

7.2

4.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

329

1.04

0.04

2.6

2.1

80.63

75.37

nmol/l

0.54

275

(3020682) Albumin/Creatinine [Ratio] in Urine

280

1.05

0.03

4.6

3.7

35.71

8.14

mg/mmol

0.43

181

(3013707) Erythrocyte sedimentation rate by Westergren method

611

0.97

0.03

7.0

4.2

21.13

14.86

mm/h

1.45

554

(3026008) Bacteria identified in Urine by Culture

312

1.03

0.02

5.6

3.7

—

(3019069) Monocytes/100 leukocytes in Blood

378

0.97

0.02

12.8

6.1

8.07

8.97

1.04

351

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

217

0.96

0.01

3.4

2.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

306

1.02

0.00

3.7

3.3

2.31

2.33

mmol/l

0.43

267

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

382

0.99

0.00

3.2

3.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

153

0.98

0.00

3.9

2.8

0.93

1.25

e6/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

409

1.00

0.00

6.9

5.6

0.00

estimate

-0.00

(3009261) Glucose [Presence] in Urine by Test strip

415

0.98

0.00

6.2

4.2

0.00

estimate

—

(3002030) Lymphocytes/100 leukocytes in Blood

384

0.99

0.00

12.1

6.0

25.99

25.39

0.08

356

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

82.80

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.4

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.8

—

10.32

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.4

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.0

1.8

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

3.8

—

8.65

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

105.00

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

2.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.2

—

(3022145) Colonoscopy Study observation

0.88

0.00

1.6

1.2

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

2.0

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.2

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.2

—

148.40

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

192.80

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

(3036603) Volume of Urine

0.00

0.0

1.0

—

1376.00

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

3.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(3022621) pH of Urine by Test strip

0.93

-0.00

2.2

3.4

—

(3035350) Ketones [Presence] in Urine by Test strip

410

1.00

-0.00

6.2

4.2

0.00

estimate

-0.00

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_INORGPNEUMOC and mortality.

Females

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.348 [1.93, 2.85]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.312

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 557 females with J10_INORGPNEUMOC died.

Males

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.514 [2.05, 3.08]	< 0.001
Birth year	0.985 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 496 out of 715 males with J10_INORGPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_INORGPNEUMOC.

N-year risk	Females	Males
1	0.211%	0.488%
5	1.365%	2.745%
10	3.496%	6.969%
15	6.78%	12.907%
20	11.869%	21.3%

Relationships between endpoints

↥

Index endpoint: J10_INORGPNEUMOC – Pneumoconiosis due to other inorganic dusts

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to other inorganic dusts

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints