Pneumoconiosis due to other inorganic dusts

J10_INORGPNEUMOC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J63 Hospital discharge: ICD-9 — 503 Hospital discharge: ICD-8 — 51600 Cause of death: ICD-10 — J63 Cause of death: ICD-9 — 503 Cause of death: ICD-8 — 51600 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	134

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Pneumoconiosis ex aliis pulveribus inorganicis

NAME	J10_INORGPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J63
HD_ICD_9	503
HD_ICD_8	51600
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J63
COD_ICD_9	503
COD_ICD_8	51600
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to other inorganic dusts based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1874	796	1036
Only index persons	1034	447	587
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	72.58	76.03	69.86
Only index persons	68.26	72.40	65.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	134	40	94
Unadjusted period prevalence (%)	0.03	0.01	0.04
Median age at first event (years)	68.26	65.91	69.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
127: Matched controls
1269

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J63.3

ICD-10 Finland

Graphite fibrosis (of lung)

+∞

49.2

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

10.6

26.6

J63.8

ICD-10 Finland

Pneumoconiosis due to other specified inorganic dusts

+∞

24.8

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

12.4

23.0

J63.4

ICD-10 Finland

Siderosis

+∞

20.3

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

6.1

18.0

162

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

+∞

11.6

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

6.0

10.7

B01AC07

ATC

dipyridamole; systemic

5.1

9.1

J63.1

ICD-10 Finland

Bauxite fibrosis (of lung)

+∞

8.4

J63.0

ICD-10 Finland

Aluminosis (of lung)

+∞

8.4

51600

ICD-8 Finland

Other pneumoconiosis and related diseases, Due to inhalation of other inorganic dust

+∞

7.4

I63.1

ICD-10 Finland

Cerebral infarction due to embolism of precerebral arteries

13.1

7.2

AA1AD

NOMESCO Finland

CT of head and brain

3.0

7.2

226

B01AC04

ATC

clopidogrel; oral

3.2

7.1

180

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.8

6.8

296

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

5.8

6.6

H53.4

ICD-10 Finland

Visual field defects

15.4

6.5

J63.5

ICD-10 Finland

Stannosis

+∞

6.3

5030A

ICD-9 Finland

Pneumoconiosis due to other inorganic dust[PNEUMOCONIOSIS ALIA DEFINITA]

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.14

3.41

4.8

6.0

25.9

24.5

mmol/l

0.73

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.69

3.29

1.9

1.7

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

6.64

3.22

2.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.12

2.94

10.7

8.8

—

(3000494) Fungus identified in Specimen by Culture

2.16

2.12

2.4

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

356

0.51

2.10

5.6

4.7

23.3

21.8

—

179

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.76

1.90

1.1

1.4

—

(3026361) Erythrocytes [#/volume] in Blood

883

0.64

1.75

44.8

26.1

4.4

e12/l

0.06

849

(3035941) MCH [Entitic mass]

883

0.64

1.75

44.5

26.0

30.3

30.5

0.24

863

(3024731) MCV [Entitic volume]

882

0.64

1.73

44.5

26.1

92.4

91.8

0.48

862

(3007461) Platelets [#/volume] in Blood

881

0.64

1.71

44.6

26.1

239.0

236.2

e9/l

0.14

852

(40760888) Immunoglobulin light chains.free panel - Serum

3.25

1.68

1.2

4.2

—

(3000991) Gas panel - Venous blood

2.05

1.55

9.1

7.4

—

(40761511) CBC panel - Blood by Automated count

818

0.68

1.41

29.9

17.7

—

(3020891) Body temperature

2.28

1.40

1.4

3.9

—

(3049717) Cytology report of Urine Cyto stain

2.17

1.31

2.0

2.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.46

1.26

2.2

3.2

5.2

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.46

1.26

2.2

3.2

7.3

7.9

kpa

—

(3007853) Bacteria identified in Skin by Aerobe culture

111

1.72

1.19

3.7

2.0

—

(3032080) INR in Blood by Coagulation assay

402

1.43

1.17

19.6

10.4

1.5

1.4

inr

0.32

114

(3017732) Neutrophils [#/volume] in Blood

1.98

1.16

5.5

3.0

3.4

3.5

e9/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.90

1.13

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

113

1.68

1.12

10.2

9.6

—

(3003338) MCHC [Mass/volume]

623

0.71

1.12

36.4

24.3

327.9

331.3

g/l

1.40

617

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.33

1.12

1.0

3.5

45.5

70.5

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.33

1.12

1.0

3.5

52.7

39.5

mg/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.01

1.11

2.6

1.6

—

(3025941) Bacteria identified in Stool by Culture

2.02

1.06

1.6

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.32

1.04

1.6

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

757

0.73

1.03

8.6

6.7

44.3

41.6

mmol/mol

0.93

687

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

448

1.39

1.03

9.2

7.1

1.2

mmol/l

0.11

370

(36304419) Bacteria [Presence] in Urine

245

1.46

1.03

4.6

3.0

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.86

0.99

2.4

2.6

9.4

10.4

g/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.78

0.96

1.3

2.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

249

1.43

0.94

2.2

1.8

1340.8

1187.3

nmol/l

0.56

189

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

747

0.75

0.89

30.0

17.3

71.6

71.3

ml/min/173m2

0.04

611

(3010421) pH of Blood

2.05

0.88

2.2

3.3

7.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

844

0.75

0.88

15.4

10.8

22.2

22.7

u/l

0.18

802

(3020564) Creatinine [Moles/volume] in Serum or Plasma

853

0.75

0.87

32.3

21.4

90.0

87.3

umol/l

0.15

853

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

271

1.39

0.87

2.7

2.3

60.3

54.5

u/l

0.35

249

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

431

1.34

0.85

5.2

4.8

31.7

58.7

ng/l

1.47

336

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.79

0.84

2.9

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

338

1.35

0.82

4.7

3.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

791

0.76

0.82

5.9

5.2

2.2

2.5

mmol/l

2.17

701

(3009542) Hematocrit [Volume Fraction] of Blood

681

0.76

0.80

34.0

19.3

38.9

37.9

0.26

400

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.79

0.0

2.7

—

(1616796) Gas panel - Central venous blood

2.22

0.77

2.6

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

178

1.42

0.75

2.9

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.71

3.1

1.8

—

(3037756) Immunofixation for Serum or Plasma

1.96

0.71

1.4

1.3

—

(40761535) Cells panel - Urine sediment

1.61

0.71

6.1

4.1

—

(3023368) Bacteria identified in Blood by Culture

327

1.32

0.70

7.5

4.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

128

1.47

0.70

1.2

1.5

2.8

g/l

0.03

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.55

0.70

4.8

2.2

4.1

10.6

umol/l

2.20

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

762

0.78

0.69

5.1

4.6

3.9

4.3

mmol/l

2.82

682

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

780

0.79

0.67

5.8

5.1

6.5

6.1

mmol/l

0.62

681

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

756

0.80

0.62

5.2

4.6

1.3

1.4

mmol/l

2.24

668

(3029937) Albumin [Presence] in Urine by Test strip

243

1.30

0.56

7.4

4.5

0.0

estimate

0.00

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

356

1.26

0.56

3.2

3.6

2884.9

2065.0

ng/l

0.41

297

(3019060) Gas panel - Arterial blood

1.49

0.54

2.7

3.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.41

0.52

1.8

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

577

0.81

0.51

4.8

3.5

15.2

15.1

pmol/l

0.16

499

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.40

0.42

1.8

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3017354) Segmented neutrophils/100 leukocytes in Blood

0.00

0.41

0.0

3.4

—

50.9

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.41

0.0

1.3

—

54318.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.44

0.39

4.4

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.37

0.39

1.6

1.4

—

(40768797) Stomach Pathology biopsy report

114

0.68

0.39

2.0

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

293

1.21

0.39

4.7

3.2

70.2

296.4

e6/l

0.50

227

(3005322) IgE [Units/volume] in Serum or Plasma

1.40

0.38

1.4

1.1

15.2

133.9

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

146

0.73

0.38

4.4

3.0

1.4

2.5

e6/l

—

(4010399)

1.33

0.38

1.8

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.33

0.38

10.1

3.2

2.4

1.7

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

733

0.85

0.36

4.5

4.1

1.3

1.2

mmol/l

0.51

643

(36660697) Celiac disease serology panel - Serum

1.45

0.36

1.3

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.40

0.35

7.7

3.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

118

1.31

0.35

3.2

4.2

225.3

248.4

u/l

0.58

109

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

192

1.24

0.35

6.7

3.5

172.9

239.5

ng/l

0.15

169

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.38

0.35

1.0

2.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

137

1.28

0.34

1.3

1.1

7.7

1.1

u/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

355

1.18

0.33

2.8

2.4

—

(3027945) Reticulocytes/100 erythrocytes in Blood

147

1.26

0.33

4.9

3.1

1.7

0.08

128

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.29

0.32

3.0

2.6

—

(3042936) Bacteria identified in Isolate by Culture

129

1.27

0.32

2.1

2.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

232

1.21

0.32

4.2

2.9

355.0

3764.5

umol/l

0.81

184

(3022313) Gas panel - Capillary blood

1.34

0.31

11.7

3.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

387

1.16

0.30

2.5

2.2

115.6

90.7

pmol/l

1.30

194

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

226

0.81

0.30

2.2

2.8

26.0

33.4

u/l

1.33

215

(3011397) Hemoglobin [Presence] in Urine by Test strip

177

1.22

0.30

6.2

4.6

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

272

1.18

0.29

2.5

2.2

4.0

3.2

mg/l

1.23

235

(3012516) Albumin [Mass/volume] in Urine

263

1.18

0.29

3.5

3.3

1961.7

529.0

mg/l

0.35

176

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

187

1.21

0.29

2.2

1.8

0.7

1.7

mg/l

2.39

149

(3044889) 12 lead EKG panel

583

0.88

0.27

5.4

4.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

333

1.15

0.26

6.5

4.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.21

0.25

10.4

3.1

5.5

4.9

kpa

—

(4035726)

0.72

0.25

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.36

0.24

1.4

1.2

—

(3012544) pH of Venous blood

1.27

0.23

1.7

4.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

6.2

2.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

116

1.23

0.23

2.9

1.8

—

(3003694) ABO and Rh group [Type] in Blood

188

0.83

0.23

1.4

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.25

0.22

1.2

1.3

103.4

45.0

iu/ml

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

117

1.22

0.21

2.9

1.8

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

7.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(4146454)

0.00

0.21

0.0

2.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

2.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.3

—

76.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

5.0

—

(3019225) pH of Specimen

1.23

0.20

14.7

4.7

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.20

0.0

1.1

—

(3000492) Spirometry study

1.16

0.19

1.8

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.16

0.19

6.8

1.6

1.8

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

236

0.87

0.18

5.7

3.7

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

410

1.11

0.18

5.5

4.7

32.5

34.5

g/l

1.22

381

(40758558) Short blood count panel - Blood

196

1.15

0.18

7.0

6.9

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.14

0.17

3.4

3.5

—

0.5

—

(3009508) Creatinine [Moles/volume] in Urine

265

1.12

0.16

3.4

3.1

7.0

7.1

mmol/l

0.04

214

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.13

0.16

4.6

4.0

1.2

mmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.22

0.16

1.7

1.5

—

(40768804) Tissue Pathology biopsy report

325

0.90

0.15

2.1

—

(3013512) EKG study

294

0.90

0.15

5.1

4.6

—

(3002256) Pathology report gross observation

100

0.79

0.14

1.3

—

(3022096) Basophils/100 leukocytes in Blood

373

0.92

0.13

12.5

5.6

0.6

0.04

345

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

1.17

0.13

7.3

3.6

—

(3044640) Blood type and Crossmatch panel - Blood

291

0.91

0.12

3.6

2.7

—

(3018095) Leukocytes [#/volume] in Urine

331

1.08

0.10

5.2

3.7

32.6

54.8

e6/l

0.57

252

(3018010) Neutrophils/100 leukocytes in Blood

378

0.93

0.09

10.1

5.5

62.5

59.0

0.89

352

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.10

0.09

1.2

1.8

—

(1761868) Lipid panel - Serum or Plasma

195

0.91

0.08

1.8

3.5

—

(3018418) pH of Serum or Plasma

254

1.08

0.08

3.0

4.1

7.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.79

0.08

1.2

3.0

—

63.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.08

0.08

2.6

1.3

—

(3006504) Eosinophils/100 leukocytes in Blood

376

0.94

0.07

12.3

5.7

2.3

2.8

0.82

348

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.86

0.07

4.6

2.8

198.8

211.7

ng/l

—

(42870588) Differential panel, method unspecified - Blood

294

0.94

0.06

10.9

5.3

—

(3026008) Bacteria identified in Urine by Culture

307

1.06

0.05

5.5

3.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

594

0.96

0.05

7.2

4.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

191

0.93

0.05

2.4

3.1

2.4

2.5

mmol/l

0.34

166

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

329

1.04

0.04

2.6

2.1

80.6

75.4

nmol/l

0.54

275

(3020682) Albumin/Creatinine [Ratio] in Urine

280

1.05

0.03

4.6

3.9

35.7

8.1

mg/mmol

0.43

181

(3013707) Erythrocyte sedimentation rate by Westergren method

611

0.97

0.03

7.0

4.2

21.1

14.9

mm/h

1.45

554

(40760892) CBC W Ordered Manual Differential panel - Blood

161

1.06

0.03

5.7

4.4

—

(3019069) Monocytes/100 leukocytes in Blood

378

0.97

0.02

12.8

6.0

8.1

9.0

1.04

351

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

217

0.96

0.01

3.4

2.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

306

1.02

0.00

3.7

3.3

2.3

mmol/l

0.42

265

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

382

0.99

0.00

4.9

4.8

—

(3035350) Ketones [Presence] in Urine by Test strip

408

1.01

0.00

6.2

4.2

0.0

estimate

0.00

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

153

0.98

0.00

3.9

2.8

0.9

1.2

e6/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

409

1.00

0.00

6.9

5.6

0.0

estimate

0.00

(3009261) Glucose [Presence] in Urine by Test strip

415

0.98

0.00

6.2

4.2

0.0

estimate

—

(3002030) Lymphocytes/100 leukocytes in Blood

384

0.99

0.00

12.1

5.9

26.0

25.3

0.10

351

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

2.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.4

—

(44806420)

0.00

0.0

2.6

—

(4268621)

0.00

0.0

1.8

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.4

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

2.2

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(4281824)

0.00

0.0

1.0

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

105.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

3.8

—

8.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.7

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.4

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.2

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.8

—

10.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3022145) Colonoscopy Study observation

0.88

0.00

1.6

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3022621) pH of Urine by Test strip

0.93

0.00

2.2

3.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

3.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_INORGPNEUMOC and mortality.

Females

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.348 [1.93, 2.85]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.312

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 557 females with J10_INORGPNEUMOC died.

Males

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.514 [2.05, 3.08]	< 0.001
Birth year	0.985 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 496 out of 715 males with J10_INORGPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_INORGPNEUMOC.

N-year risk	Females	Males
1	0.211%	0.488%
5	1.365%	2.745%
10	3.496%	6.969%
15	6.78%	12.907%
20	11.869%	21.3%

Relationships between endpoints

↥

Index endpoint: J10_INORGPNEUMOC – Pneumoconiosis due to other inorganic dusts

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to other inorganic dusts

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints