Maxillary hypoplasia

K11_MAXIL_HYPOPL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — K07.03 Hospital discharge: ICD-10 — K07.03 Cause of death: ICD-10 — K07.03 3 out of 7 registries used, show all original rules.	124
4. Check minimum number of events None	124
5. Include endpoints None	124
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF7

NAME	K11_MAXIL_HYPOPL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	K0703
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K0703
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K0703
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Maxillary hypoplasia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3195	1607	1586
Only index persons	2886	1454	1432
Unadjusted period prevalence (%)
Whole population	0.05	0.05	0.04
Only index persons	0.05	0.05	0.05
Median age at first event (years)
Whole population	11.82	11.93	11.68
Only index persons	12.43	12.50	12.35

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	75	49
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	22.09	18.85	27.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1108

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K07.03

ICD-10 Finland

Micrognatia (hypoplasia) of the upper jaw

+∞

160.1

111

EEC05

NOMESCO Finland

Le Fort I osteotomy

141.4

30.4

K07.14

ICD-10 Finland

Retrognaty, maxillary

77.1

30.1

SBB10

NOMESCO Finland

Teeth copy

11.2

28.5

132

SJD00

NOMESCO Finland

Removal or reattacment of arrow in fixed orthodontisk device

12.4

26.1

K07.25

ICD-10 Finland

Anomalies of dental arch relationship

24.6

25.9

SJD20

NOMESCO Finland

Attachment of modifiable arrow of fixed orthodontisk device

14.0

25.4

SJX10

NOMESCO Finland

Short check-up visit for orthodontisk therapy

10.3

25.1

110

SJD10

NOMESCO Finland

Attachment of arrow to fixed orthodontisk device

11.6

24.1

SAA04

NOMESCO Finland

Special inverstigation of mouth

10.9

22.6

K07.01

ICD-10 Finland

Hyperplasia, hypoplasia mandibular

143.5

22.5

K07.11

ICD-10 Finland

Retrognathism (mandibular)(maxillary)

143.5

22.5

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

11.4

21.7

EB1MA

NOMESCO Finland

Cephalometry with X-ray

11.4

20.4

SJB00

NOMESCO Finland

Fitting of loose orthodontic device with user information

9.4

18.2

K07.13

ICD-10 Finland

Retrognaty, mandibular

22.2

18.0

SJD40

NOMESCO Finland

Fixation of ready made palatinal or lingual arrow

9.8

17.9

EDC10

NOMESCO Finland

Sagittal osteotomy of ramus of mandible

60.3

17.7

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

14.1

16.7

SJC10

NOMESCO Finland

Orthodontic bandage in one tooth

9.9

16.5

SJC50

NOMESCO Finland

Removal of orthodontisk device with at least 7 brackets

8.6

16.2

SJD30

NOMESCO Finland

Demanding attachment of arrow to fixed orthodontisk device

11.7

14.8

EFB40

NOMESCO Finland

Removal of internal or external fixation device from facial bones

61.6

14.2

SJC00

NOMESCO Finland

Bracket with fixed attachment

85.6

13.9

K07.24

ICD-10 Finland

Open bite

19.2

12.1

SJX20

NOMESCO Finland

Check-up visit for orthodontisk therapy

6.8

12.0

K07.10

ICD-10 Finland

Asymmetry of jaw

+∞

10.6

SJX11

NOMESCO Finland

Therapeutic intervention or check-up related to orthodontic treatment, restricted

5.1

10.0

K07.04

ICD-10 Finland

Macrognathism (mandibular)(maxillary)

108.9

9.6

SJC03

NOMESCO Finland

Positioning and fixed attachment of brackets, extensive

6.1

9.1

K07.30

ICD-10 Finland

Spacing, abnormal of tooth or teeth

5.3

8.9

SJA03

NOMESCO Finland

Demanding plan for orthodontic care

54.4

8.8

SAA03

NOMESCO Finland

Extended examination of mouth

3.4

8.4

436

SXC05

NOMESCO Finland

Other oral or dental procedure

4.6

8.3

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

4.7

8.1

SJB60

NOMESCO Finland

External device grinding and adaptation

5.6

7.9

SJA01

NOMESCO Finland

Estimation of need for orthodontic care

48.5

7.8

K00.00

ICD-10 Finland

Hypodontia

9.4

7.6

SJC40

NOMESCO Finland

Removal of orthodontisk device with at most 6 brackets

4.8

7.4

SHA04

NOMESCO Finland

Correction of physiology of bite - very demanding therapy visit

32.3

7.3

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

32.3

7.3

SJC01

NOMESCO Finland

Positioning and fixed attachment of single bracket (Bracket with fixed attachment)

4.5

7.2

EB1BI

NOMESCO Finland

Cone beam imaging of teeth and jaws (1–2 quarters)

15.1

7.1

SHA03

NOMESCO Finland

Correction of physiology of bite - demanding therapy visit

8.7

6.9

SXB00

NOMESCO Finland

Removeal of sutres from oral mucosa

5.9

6.7

K07.1

ICD-10 Finland

Anomalies of jaw-cranial base relationship

73.9

6.5

K07.21

ICD-10 Finland

Anomalies of dental arch relationship

28.5

6.3

EBB15

NOMESCO Finland

Insertion of dental implant abutment

+∞

6.3

SJC02

NOMESCO Finland

Positioning and fixed attachment of brackets

5.7

6.2

SJD50

NOMESCO Finland

Production and attachment of palatinal or lingual arrow

8.8

6.0

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

2.7

6.0

302

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.53

2.91

3.5

6.0

—

(3044889) 12 lead EKG panel

528

1.81

2.63

2.6

3.1

—

(40761511) CBC panel - Blood by Automated count

117

1055

2.93

2.56

10.7

8.7

—

(3000492) Spirometry study

2.14

2.08

1.4

1.5

—

(40761535) Cells panel - Urine sediment

2.45

1.94

5.0

3.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.12

1.84

1.3

1.4

46.84

120.92

iu/ml

1.37

(3002256) Pathology report gross observation

2.12

1.84

1.3

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

740

1.65

1.74

4.9

3.6

14.65

14.44

pmol/l

0.35

675

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

203

1.70

1.67

1.8

2.3

0.74

0.87

mg/l

0.13

148

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.19

1.66

2.8

2.6

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.32

1.62

1.3

2.1

99.83

85.12

ml/min/173m2

—

(3044640) Blood type and Crossmatch panel - Blood

265

1.63

1.62

3.6

2.2

—

(3029937) Albumin [Presence] in Urine by Test strip

239

1.65

1.62

3.7

3.1

0.00

0.01

estimate

0.50

103

(3019225) pH of Specimen

2.10

1.61

2.6

4.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

257

1.63

1.60

5.1

4.9

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.43

1.54

1.2

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.43

1.54

1.0

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.43

1.54

2.0

—

(4034850)

2.95

1.52

7.3

9.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

357

1.51

1.36

5.9

6.5

1.22

mmol/l

0.26

313

(40761536) Microorganisms panel - Urine sediment

1.87

1.30

1.6

2.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

655

1.46

1.22

8.3

6.8

78.71

78.13

u/l

0.04

613

(40758558) Short blood count panel - Blood

255

1.52

1.21

6.2

6.0

—

(3021589) Normoblasts [#/volume] in Blood

469

1.44

1.20

8.8

7.6

0.00

e9/l

0.00

385

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

422

1.45

1.18

6.1

3.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.82

1.14

1.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

188

1.56

1.14

2.0

2.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

2.44

1.10

1.6

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

446

1.42

1.10

3.3

3.2

0.00

estimate

0.00

105

(3013826) Glucose [Moles/volume] in Serum or Plasma

504

1.41

1.09

4.7

4.4

6.50

6.16

mmol/l

0.70

449

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

148

1.59

1.07

1.8

2.1

—

(3013115) Eosinophils [#/volume] in Blood

535

1.41

1.07

8.4

6.6

0.19

0.18

e9/l

0.12

488

(3003694) ABO and Rh group [Type] in Blood

328

1.42

1.02

1.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.90

1.01

1.8

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

442

1.39

1.00

4.0

4.6

0.00

estimate

0.00

108

(3011288) Drugs identified in Urine by Screen method

1.73

0.99

1.3

1.9

—

(3022145) Colonoscopy Study observation

1.69

0.92

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

180

1.49

0.91

3.3

3.9

1.33

16.82

mg/mmol

1.81

118

(3025941) Bacteria identified in Stool by Culture

1.92

0.89

1.1

1.2

—

(3006315) Basophils [#/volume] in Blood

519

1.35

0.86

8.1

6.3

0.03

0.04

e9/l

0.41

467

(3012516) Albumin [Mass/volume] in Urine

174

1.47

0.85

3.3

9.03

134.03

mg/l

1.95

115

(3001604) Monocytes [#/volume] in Blood

520

1.34

0.84

8.1

6.3

0.52

0.54

e9/l

0.37

467

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

338

1.37

0.84

3.6

3.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.79

0.84

1.8

1.2

—

(42870588) Differential panel, method unspecified - Blood

322

1.36

0.80

6.5

6.1

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.79

0.0

1.1

—

2.70

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

286

1.36

0.78

2.9

3.3

—

(36660697) Celiac disease serology panel - Serum

118

1.51

0.74

1.4

1.1

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

109

1027

1.51

0.73

10.9

8.6

26.23

27.26

u/l

0.28

103

999

(3023511) Choriogonadotropin [Units/volume] in Urine

1.62

0.73

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

452

1.30

0.70

3.4

3.3

0.00

0.03

estimate

0.50

106

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

404

1.31

0.70

9.2

6.9

10.90

12.36

umol/l

0.36

385

(3052851) Hemolysis interference index of Serum or Plasma

1.89

0.69

2.4

2.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

200

1.38

0.68

3.5

2.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.82

0.67

1.4

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.63

0.66

1.1

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

724

1.30

0.66

5.0

4.3

38.80

37.66

mmol/mol

0.44

690

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

157

1.41

0.64

3.4

4.0

784.47

531.78

ng/l

0.23

132

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.61

0.0

1.2

—

(4268621)

0.00

0.61

0.0

2.1

—

(3027944) Amphetamines [Presence] in Urine

115

1.45

0.60

1.4

1.7

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.60

0.0

2.4

—

136.50

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.51

0.58

3.1

2.7

1.21

1.22

mmol/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

104

982

1.37

0.58

12.0

10.7

41.18

40.77

0.41

829

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.70

0.57

1.3

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

280

1.30

0.57

2.1

2.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

197

1.34

0.57

4.5

3.3

—

(40768804) Tissue Pathology biopsy report

319

1.28

0.55

1.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

692

1.25

0.55

4.2

3.7

9.08

8.08

mm/h

0.38

647

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

358

1.26

0.54

2.0

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

273

1.28

0.54

1.8

1.6

110.22

96.91

pmol/l

0.69

145

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

264

1.29

0.53

4.1

2.3

46.97

56.35

u/l

1.98

243

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.52

0.52

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

106

1008

1.36

0.52

13.3

10.2

18.27

19.51

mg/l

0.18

733

(3027008) Opiates [Presence] in Urine

119

1.40

0.51

1.4

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

881

1.28

0.51

5.3

4.2

1.81

1.87

mu/l

0.16

831

(3028300) Cannabinoids [Presence] in Urine

120

1.38

0.49

1.4

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

268

1.26

0.47

2.6

3.1

394.50

35.60

ng/l

0.44

136

(3032080) INR in Blood by Coagulation assay

268

1.26

0.47

3.8

4.0

1.09

1.06

inr

0.19

(3018418) pH of Serum or Plasma

212

1.29

0.47

2.5

2.8

7.40

—

(3012544) pH of Venous blood

0.57

0.47

3.2

6.1

—

(1761868) Lipid panel - Serum or Plasma

354

1.24

0.47

2.4

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

354

1.24

0.47

1.9

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

129

0.67

0.46

2.0

1.9

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.41

0.46

4.3

2.5

2390.40

5077.72

u/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

592

1.21

0.43

3.5

3.7

—

19.00

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

115

1.35

0.41

11.2

6.3

0.85

0.81

mmol/l

1.08

109

(1616796) Gas panel - Central venous blood

0.00

0.40

0.0

1.7

—

(3013512) EKG study

189

1.27

0.40

3.5

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

636

1.19

0.39

2.8

3.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

850

1.21

0.39

10.5

8.7

100.37

96.75

ml/min/173m2

0.75

651

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

303

1.22

0.39

2.0

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

266

1.22

0.37

1.6

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.35

0.37

2.6

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

118

1154

1.47

0.34

19.6

14.9

137.37

137.50

g/l

0.03

118

1144

(3035941) MCH [Entitic mass]

118

1153

1.48

0.34

19.0

14.5

30.04

29.95

0.21

118

1142

(3024731) MCV [Entitic volume]

118

1153

1.48

0.34

19.1

14.5

89.53

89.39

0.12

118

1143

(3026361) Erythrocytes [#/volume] in Blood

118

1153

1.48

0.34

19.2

14.6

4.60

e12/l

0.01

118

1129

(3007461) Platelets [#/volume] in Blood

118

1152

1.50

0.34

19.1

14.6

257.26

257.95

e9/l

0.04

118

1128

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.65

0.34

1.0

—

(21494755) Public health laboratory ask at order entry panel

130

1.26

0.30

1.2

1.3

—

(4035726)

1.29

0.30

1.7

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

158

1.24

0.30

1.4

1.3

21.40

21.03

iu/ml

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

150

1.23

0.28

1.6

1.3

2.16

6.04

u/ml

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.23

0.27

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

266

1.17

0.26

2.0

2.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

180

1.20

0.26

1.7

1.5

—

(36304419) Bacteria [Presence] in Urine

239

1.17

0.24

2.1

3.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

318

1.14

0.22

1.8

1.3

1.17

1.18

u/ml

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.0

—

26.90

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

4.0

—

14.54

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.21

0.0

1.9

—

79.80

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.0

—

30.09

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

31.51

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

25.3

—

1733.83

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.1

—

722.75

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

1.42

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

146

1.19

0.20

2.4

3.2

0.65

0.72

e6/l

0.09

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.24

0.20

1.3

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.20

0.0

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.8

—

(44790048)

0.00

0.20

0.0

1.2

—

(44790049)

0.00

0.20

0.0

1.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.1

—

(44790047)

0.00

0.20

0.0

1.2

—

(44806118)

0.00

0.20

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

118

1.21

0.20

1.5

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.21

0.20

1.2

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

100

1.22

0.19

1.2

1.9

—

(3016879) Cocaine [Presence] in Urine

110

1.20

0.18

1.2

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.14

0.17

1.7

1.6

—

(3018095) Leukocytes [#/volume] in Urine

313

1.12

0.17

2.3

3.7

5.05

41.03

e6/l

1.98

213

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.75

0.17

1.2

4.9

65.40

61.66

ng/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.75

0.17

1.0

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

284

1.12

0.17

1.6

1.4

1.73

2.04

g/l

0.82

169

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.19

0.17

1.8

2.0

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.19

0.17

20.5

8.1

5.28

6.56

mmol/l

—

(3015736) pH of Urine

353

1.11

0.16

3.7

3.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.79

0.16

1.0

1.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.15

0.15

2.2

5.1

5.10

kpa

—

(3009343) pH of Capillary blood

1.13

0.15

2.2

5.0

—

7.42

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.11

0.15

3.3

2.6

25.33

29.66

u/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.80

0.15

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

835

1.10

0.14

3.6

3.4

5.68

5.64

mmol/l

0.16

782

(3021879) Hepatitis B virus core Ab [Presence] in Serum

104

1.17

0.13

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

850

1.08

0.10

4.0

3.8

2.70

2.79

mmol/l

0.45

805

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

891

1.08

0.10

4.1

3.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.12

0.10

1.2

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.04

0.09

5.2

4.9

75.00

93.81

—

(3022621) pH of Urine by Test strip

1.06

0.08

1.5

2.1

—

(4010399)

1.04

0.08

1.0

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

0.83

0.08

1.4

1.8

—

(3008898) HLA-B27 [Presence]

0.80

0.08

1.0

—

(3022313) Gas panel - Capillary blood

1.10

0.08

2.1

5.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.13

0.08

1.3

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.85

0.07

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

118

1.11

0.07

1.8

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.13

0.07

1.5

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.88

0.07

1.4

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

233

0.93

0.06

1.6

1.8

—

(3042936) Bacteria identified in Isolate by Culture

111

1.09

0.04

2.7

2.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

119

0.92

0.04

3.1

2.2

15.85

15.57

umol/l

0.05

106

(3030467) Casts [#/volume] in Urine by Automated count

240

1.05

0.04

2.2

3.2

0.13

0.21

e6/l

0.42

179

(3000494) Fungus identified in Specimen by Culture

102

1.09

0.03

3.0

1.8

—

(3026008) Bacteria identified in Urine by Culture

239

0.95

0.03

2.7

2.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

122

1.07

0.03

4.9

4.3

28.45

19.36

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

117

0.93

0.02

1.3

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

164

1.04

0.00

2.2

1.4

—

(40768797) Stomach Pathology biopsy report

101

0.99

0.00

1.4

1.3

—

(3003338) MCHC [Mass/volume]

925

0.98

0.00

16.4

12.5

333.51

334.20

g/l

0.31

915

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

205

0.97

0.00

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.93

0.00

2.4

1.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.49

—

(40768446) Kidney Pathology biopsy report

0.00

0.0

1.6

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

3.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(3023368) Bacteria identified in Blood by Culture

160

1.00

0.00

3.8

3.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

1.1

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.32

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.3

—

(4211845)

0.00

0.0

1.6

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

91.40

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

12.73

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

8.2

—

0.51

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

1.24

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.6

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.90

0.00

2.0

4.1

33.30

7.66

umol/l

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

0.0

2.0

—

19.65

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.6

—

197.14

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1650.60

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

137.23

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.36

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

8.8

—

27.00

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

9.1

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.6

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint K11_MAXIL_HYPOPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MAXIL_HYPOPL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: K11_MAXIL_HYPOPL – Maxillary hypoplasia

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Maxillary hypoplasia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints