Maxillary hypoplasia

K11_MAXIL_HYPOPL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — K07.03 Hospital discharge: ICD-10 — K07.03 Cause of death: ICD-10 — K07.03 3 out of 7 registries used, show all original rules.	128
4. Check minimum number of events None	128
5. Include endpoints None	128
6. Filter based on genotype QC (FinnGen only)	121

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF7

NAME	K11_MAXIL_HYPOPL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	K0703
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K0703
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K0703
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Maxillary hypoplasia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3195	1607	1586
Only index persons	2886	1454	1432
Unadjusted period prevalence (%)
Whole population	0.05	0.05	0.04
Only index persons	0.05	0.05	0.05
Median age at first event (years)
Whole population	11.82	11.93	11.68
Only index persons	12.43	12.50	12.35

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	121	72	49
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	22.24	18.98	27.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
128: Matched controls
1280

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K07.03

ICD-10 Finland

Micrognatia (hypoplasia) of the upper jaw

+∞

184.8

128

K07.25

ICD-10 Finland

Anomalies of dental arch relationship

25.0

59.5

SJD20

NOMESCO Finland

Placement of modified orthodontic arch wire

18.4

52.2

SJD00

NOMESCO Finland

Removal and/or reactivation of orthodontic arch wire

14.3

48.8

SBB10

NOMESCO Finland

Dental impressions

12.1

46.5

151

SJD10

NOMESCO Finland

Placement of orthodontic arch wire

13.4

45.2

SAA04

NOMESCO Finland

Special examination of mouth

11.7

39.3

K07.14

ICD-10 Finland

Retrognaty, maxillary

184.8

39.2

SBB00

NOMESCO Finland

Clinical photography of mouth and teeth

12.7

39.2

SJX10

NOMESCO Finland

Orthodontic treatment/control appointment, short

9.8

37.8

118

EB1MA

NOMESCO Finland

Cephalometry with X-ray

11.4

36.2

EEC05

NOMESCO Finland

Le Fort I osteotomy

462.4

35.8

SJB00

NOMESCO Finland

Fitting of removable appliance incl. patient instructions

10.6

35.0

SJD40

NOMESCO Finland

Placement of prefabricated palatal or lingual arch

9.6

30.9

WZC10

NOMESCO Finland

Written specialist consultation based on a referral from a dentist or a physician

12.3

30.6

SJC50

NOMESCO Finland

Removal of fixed orthodontic appliance with at least 7 brackets

9.5

29.3

SJD30

NOMESCO Finland

Demanding placement of orthodontic arch wire

13.3

29.2

K07.11

ICD-10 Finland

Retrognathism (mandibular)(maxillary)

123.8

28.0

SJC10

NOMESCO Finland

Orthodontic band in one tooth

8.8

26.1

K07.01

ICD-10 Finland

Hyperplasia, hypoplasia mandibular

153.8

24.6

EDC10

NOMESCO Finland

Sagittal osteotomy of ramus of mandible

49.6

17.9

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

6.9

17.7

SJX20

NOMESCO Finland

Orthodontic treatment/control appointment

6.2

17.7

K07.13

ICD-10 Finland

Retrognaty, mandibular

17.6

17.3

SJB60

NOMESCO Finland

Adjustment and grinding of removable appliance

6.8

16.6

EFB40

NOMESCO Finland

Removal of internal or external fixation device from facial bones

97.3

16.0

SJC00

NOMESCO Finland

Bondable bracket or other fixed attachement

181.2

15.9

SJC01

NOMESCO Finland

Positioning and fixed attachment of single bracket (Bracket with fixed attachment)

6.4

15.2

SJC03

NOMESCO Finland

Positioning and fixed attachment of brackets, extensive

6.7

15.0

K07.24

ICD-10 Finland

Open bite

13.7

12.9

K07.30

ICD-10 Finland

Spacing, abnormal of tooth or teeth

5.0

12.9

SJX11

NOMESCO Finland

Therapeutic intervention or check-up related to orthodontic treatment, restricted

4.7

12.6

SXB00

NOMESCO Finland

Removal of sutures from oral mucosa

5.9

11.5

SXC05

NOMESCO Finland

Other oral or dental procedure

4.2

11.2

113

WZC00

NOMESCO Finland

Treatment plan or consultation

3.3

10.2

373

SHA03

NOMESCO Finland

Stomatognathic treatment, demanding

9.1

10.1

K00.00

ICD-10 Finland

Hypodontia

12.9

9.9

SJA03

NOMESCO Finland

Demanding workplan for orthodontic treatment

59.6

9.8

SAA03

NOMESCO Finland

Extended examination of mouth

3.5

9.8

537

SJC40

NOMESCO Finland

Removal of fixed orthodontic appliance with at most 6 brackets

4.4

9.6

EBB15

NOMESCO Finland

Insertion of dental implant abutment

+∞

9.5

SJC02

NOMESCO Finland

Positioning and fixed attachment of brackets

5.5

9.2

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

5.5

9.2

EBB10

NOMESCO Finland

Insertion of dental implant

53.8

8.8

K07.04

ICD-10 Finland

Macrognathism (mandibular)(maxillary)

53.8

8.8

EB1BI

NOMESCO Finland

Cone beam imaging of teeth and jaws (1–2 quarters)

21.9

8.6

K07.18

ICD-10 Finland

Another anomaly in the relationship between jaw and skull base

+∞

8.4

K07.10

ICD-10 Finland

Asymmetry of jaw

35.8

8.2

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.9

7.9

475

SJA01

NOMESCO Finland

Assesment of orthodontic treatment need

48.0

7.8

K07.1

ICD-10 Finland

Anomalies of jaw-cranial base relationship

48.0

7.8

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

48.0

7.8

SPA00

NOMESCO Finland

Changing form of teeth in prepation for prosthodontic work

13.0

7.8

ZXA10

NOMESCO Finland

Bilateral

3.4

7.5

120

SHA02

NOMESCO Finland

Stomatognathic treatment, basic

4.1

7.4

SHA04

NOMESCO Finland

Stomatognathic treatment, very demanding

17.0

7.4

SJX21

NOMESCO Finland

Therapeutic intervention or check-up related to orthodontic treatment

4.0

7.2

EBB11

NOMESCO Finland

Insertion of additional dental implant in one session

+∞

6.3

SJD50

NOMESCO Finland

Placement of prefabricated palatal or lingual arch, dentist-made

7.9

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.78

3.76

3.3

5.9

—

(40761511) CBC panel - Blood by Automated count

121

1088

3.05

2.70

10.6

8.6

—

(3044889) 12 lead EKG panel

544

1.80

2.66

2.6

3.0

—

(40761535) Cells panel - Urine sediment

2.62

2.36

4.7

3.4

—

(3000492) Spirometry study

2.17

2.24

1.5

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.54

2.09

1.2

2.1

99.83

85.12

ml/min/173m2

—

(4034850) Laboratory test

3.46

1.99

6.6

9.2

—

(3029937) Albumin [Presence] in Urine by Test strip

243

1.74

1.99

3.6

3.4

0.00

0.01

estimate

0.50

105

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.88

1.96

1.0

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

213

1.74

1.87

1.8

2.3

0.71

0.85

mg/l

0.14

157

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

767

1.64

1.76

4.8

3.6

14.70

14.46

pmol/l

0.45

700

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.18

1.66

2.8

2.6

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.01

1.63

1.3

1.4

46.84

123.49

iu/ml

1.50

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

374

1.55

1.57

5.6

6.5

1.22

mmol/l

0.40

332

(3019225) pH of Specimen

2.06

1.56

2.6

4.8

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.42

1.54

1.2

1.3

—

(3002256) Pathology report gross observation

1.94

1.49

1.3

1.2

—

(40758558) Short blood count panel - Blood

270

1.58

1.48

5.9

—

(3044640) Blood type and Crossmatch panel - Blood

272

1.56

1.43

3.6

2.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.94

1.43

1.1

1.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

676

1.49

1.34

8.2

6.8

78.31

78.75

u/l

0.03

633

(40760892) CBC W Ordered Manual Differential panel - Blood

499

1.47

1.33

7.4

6.9

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.85

1.29

2.0

4.9

—

(3035350) Ketones [Presence] in Urine by Test strip

454

1.46

1.28

3.2

3.3

0.00

estimate

-0.00

113

(3021589) Normoblasts [#/volume] in Blood

484

1.45

1.25

8.7

7.7

0.00

e9/l

-0.00

398

(40761536) Microorganisms panel - Urine sediment

1.84

1.25

1.6

3.3

—

(3013115) Eosinophils [#/volume] in Blood

553

1.44

1.23

8.2

6.7

0.19

e9/l

0.12

505

(3021601) Nitrite [Presence] in Urine by Test strip

450

1.43

1.18

4.0

4.8

0.00

estimate

-0.00

110

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

432

1.43

1.16

3.3

2.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

416

1.42

1.11

8.7

6.8

10.96

12.23

umol/l

0.32

397

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

2.43

1.10

1.6

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

342

1.44

1.09

3.5

3.3

—

(3025941) Bacteria identified in Stool by Culture

2.07

1.07

1.1

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

298

1.44

1.06

2.7

3.5

—

(3003694) ABO and Rh group [Type] in Blood

335

1.43

1.05

1.6

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.32

1.04

1.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.32

1.04

1.0

1.1

—

(3006315) Basophils [#/volume] in Blood

537

1.38

1.01

7.9

6.4

0.03

0.04

e9/l

0.24

484

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

193

1.51

1.01

2.0

2.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.90

1.01

1.8

1.7

—

(3001604) Monocytes [#/volume] in Blood

538

1.38

1.00

7.9

6.4

0.52

0.54

e9/l

0.40

484

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.94

0.95

1.3

1.4

—

(3011288) Drugs identified in Urine by Screen method

1.71

0.95

1.3

1.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

153

1.53

0.93

1.8

2.1

—

(3009261) Glucose [Presence] in Urine by Test strip

460

1.34

0.86

3.3

3.4

0.00

0.03

estimate

0.50

108

(3020682) Albumin/Creatinine [Ratio] in Urine

183

1.45

0.84

3.1

3.7

1.33

16.41

mg/mmol

1.81

121

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

113

1060

1.56

0.84

10.7

8.6

26.21

27.12

u/l

0.26

107

1031

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.75

0.82

1.8

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

621

1.32

0.80

9.8

8.2

3.68

3.83

e9/l

0.24

553

(3011397) Hemoglobin [Presence] in Urine by Test strip

203

1.42

0.79

4.3

3.3

—

(3022145) Colonoscopy Study observation

1.60

0.79

1.4

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.78

0.0

1.1

—

2.70

—

(3012516) Albumin [Mass/volume] in Urine

177

1.44

0.78

3.3

9.03

130.75

mg/l

1.95

118

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

161

1.44

0.74

3.3

4.1

784.47

523.51

ng/l

0.24

135

(3019198) Lymphocytes [#/volume] in Blood

559

1.29

0.70

8.0

6.3

1.94

1.99

e9/l

0.17

514

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

272

1.34

0.70

3.9

2.3

46.26

56.37

u/l

2.37

252

(3052851) Hemolysis interference index of Serum or Plasma

1.89

0.69

2.4

2.1

—

(36660697) Celiac disease serology panel - Serum

120

1.48

0.69

1.4

1.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

610

1.28

0.68

3.4

3.8

—

19.00

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

273

1.33

0.68

2.5

3.1

371.65

35.26

ng/l

0.43

138

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.82

0.67

1.4

1.5

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.50

0.62

4.1

2.6

2390.40

4803.43

u/l

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.61

0.0

2.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.61

0.0

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.6

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

717

1.27

0.60

4.1

3.8

9.00

8.02

mm/h

0.39

670

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

110

1042

1.40

0.60

13.1

10.2

20.24

20.10

mg/l

0.02

761

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

748

1.27

0.59

5.0

4.3

38.71

37.77

mmol/mol

0.35

713

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.59

0.0

2.8

—

136.76

—

(3012544) pH of Venous blood

0.54

0.58

3.2

6.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

206

1.33

0.57

3.5

2.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.54

0.56

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

0.65

0.55

2.0

1.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

652

1.24

0.53

2.8

4.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

910

1.27

0.51

5.3

4.2

1.81

1.87

mu/l

0.15

859

(3027944) Amphetamines [Presence] in Urine

119

1.39

0.51

1.4

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

285

1.26

0.50

2.1

2.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.52

0.48

1.1

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

373

1.23

0.47

2.0

1.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

874

1.23

0.45

10.5

8.7

100.60

96.93

ml/min/173m2

0.80

674

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

280

1.24

0.44

1.8

1.6

110.22

97.06

pmol/l

0.68

147

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.46

0.43

3.1

3.6

1.21

1.22

mmol/l

—

(3027008) Opiates [Presence] in Urine

123

1.34

0.43

1.4

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.41

0.0

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.0

—

233.93

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.41

0.0

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.41

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

124

1.33

0.41

1.4

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.7

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

152

1.29

0.40

2.4

3.2

0.60

0.70

e6/l

0.14

(1616796) Gas panel - Central venous blood

0.00

0.39

0.0

4.7

—

(40768804) Tissue Pathology biopsy report

332

1.21

0.38

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

361

1.20

0.38

1.9

2.1

—

(36304419) Bacteria [Presence] in Urine

247

1.23

0.37

2.1

3.3

—

(3018095) Leukocytes [#/volume] in Urine

324

1.20

0.36

2.3

3.9

5.21

40.34

e6/l

2.00

219

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.36

1.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

118

1.31

0.35

11.2

7.0

0.85

0.81

mmol/l

1.13

112

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

155

1.27

0.35

1.6

1.3

2.09

5.87

u/ml

—

(3000963) Hemoglobin [Mass/volume] in Blood

122

1193

1.48

0.34

19.4

14.8

137.35

137.40

g/l

0.01

122

1183

(3026361) Erythrocytes [#/volume] in Blood

122

1192

1.50

0.34

19.0

14.5

4.60

e12/l

0.03

122

1168

(3035941) MCH [Entitic mass]

122

1192

1.50

0.34

18.9

14.5

30.04

29.94

0.25

122

1181

(3024731) MCV [Entitic volume]

122

1192

1.50

0.34

18.9

14.5

89.52

89.35

0.14

122

1182

(3018418) pH of Serum or Plasma

221

1.22

0.34

2.5

3.0

7.40

—

(3007461) Platelets [#/volume] in Blood

122

1191

1.52

0.34

18.9

14.6

256.65

258.71

e9/l

0.13

122

1167

(3013512) EKG study

193

1.23

0.34

3.5

3.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

166

1.24

0.32

1.4

1.3

21.40

20.17

iu/ml

—

(3022217) INR in Platelet poor plasma by Coagulation assay

318

1.18

0.32

5.7

6.6

1.15

1.06

inr

0.38

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.71

0.32

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

309

1.18

0.31

2.0

2.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

102

1.31

0.31

2.6

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

102

1.31

0.31

1.3

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

271

1.19

0.31

1.6

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.34

0.29

5.5

7.2

105.30

104.59

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

370

1.16

0.28

2.4

2.1

—

(3022313) Gas panel - Capillary blood

1.21

0.27

2.1

5.8

—

(21494755) Public health laboratory ask at order entry panel

134

1.22

0.24

1.2

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

268

1.16

0.23

2.0

2.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

183

1.18

0.22

1.7

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

856

1.13

0.22

3.5

3.4

5.68

5.65

mmol/l

0.11

801

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.0

—

26.90

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.0

—

30.09

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.21

0.0

1.9

—

79.80

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

0.31

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

6.23

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

4.0

—

14.54

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

31.51

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

25.3

—

1187.17

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.1

—

722.75

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.24

0.20

1.3

1.9

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.6

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.20

0.0

3.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.21

0.20

1.2

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

920

1.13

0.19

4.1

3.7

—

(4035726) Immunohistochemistry procedure

1.22

0.18

1.7

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

273

1.13

0.18

1.9

3.4

12.36

34.01

e6/l

1.01

210

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.14

0.17

1.7

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.74

0.17

1.0

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.72

0.17

1.2

4.9

65.40

60.80

ng/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.70

0.17

4.6

9.9

26.36

25.20

mmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.19

0.17

1.8

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.15

0.16

1.8

2.0

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.15

0.16

20.5

9.1

5.26

6.55

mmol/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.78

0.16

1.0

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

334

1.11

0.16

1.8

1.4

1.10

1.16

u/ml

0.03

(3009343) pH of Capillary blood

1.22

0.16

2.2

5.1

—

7.42

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.81

0.15

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.77

0.15

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

122

1.17

0.14

1.5

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

248

1.11

0.14

2.2

3.4

0.12

0.23

e6/l

0.56

186

(3016879) Cocaine [Presence] in Urine

113

1.17

0.13

1.2

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

117

0.84

0.13

1.3

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.07

0.09

1.2

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

144

0.89

0.09

2.2

3.2

2.65

2.48

e6/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

107

1.13

0.09

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

0.80

0.08

1.4

1.8

—

(3022948) Iron [Moles/volume] in Serum or Plasma

123

0.88

0.08

3.1

2.2

15.85

15.56

umol/l

0.05

112

(3019832) Treponema pallidum Ab [Presence] in Serum

235

0.92

0.08

1.6

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.85

0.07

1.4

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

213

0.93

0.06

1.6

—

(3023368) Bacteria identified in Blood by Culture

168

1.08

0.06

3.6

3.4

—

(3026008) Bacteria identified in Urine by Culture

253

0.94

0.06

2.7

2.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

878

1.04

0.04

4.1

3.8

2.70

2.79

mmol/l

0.43

832

(3007164) IgA [Mass/volume] in Serum or Plasma

299

1.05

0.04

1.6

1.4

1.73

2.05

g/l

0.84

177

(1001926) Buprenorphine [Presence] in Urine by Screen method

101

1.10

0.04

1.3

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.08

0.02

1.5

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

126

1.04

0.00

1.8

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

171

0.99

0.00

2.2

1.4

—

(3000494) Fungus identified in Specimen by Culture

107

1.03

0.00

3.0

1.8

—

(40768797) Stomach Pathology biopsy report

107

1.03

0.00

1.4

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

127

1.03

0.00

4.9

4.2

28.45

19.45

—

(3003338) MCHC [Mass/volume]

959

1.00

0.00

16.3

12.4

333.63

334.25

g/l

0.29

949

(3042936) Bacteria identified in Isolate by Culture

115

1.05

0.00

2.7

2.1

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.0

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1650.60

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.6

—

197.14

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

3.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.49

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

91.40

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

6.97

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.95

-0.00

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

-0.00

0.0

1.9

—

18.43

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.7

—

(3037756) Immunofixation for Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

-0.00

0.0

1.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.02

-0.00

5.2

4.8

75.00

93.55

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.2

—

0.51

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

137.23

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.90

-0.00

2.4

1.7

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.7

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.7

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.6

—

(40768446) Kidney Pathology biopsy report

0.00

-0.00

0.0

2.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3022621) pH of Urine by Test strip

1.02

-0.00

1.5

2.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

3.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.51

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

8.4

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(4200892) Spirometry reversibility

0.98

-0.00

1.0

1.5

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

7.7

—

26.00

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

12.73

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.24

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint K11_MAXIL_HYPOPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MAXIL_HYPOPL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: K11_MAXIL_HYPOPL – Maxillary hypoplasia

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Maxillary hypoplasia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints