Hypertrophy of bone

M13_BONEHYPERTRPH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M89.3 Cause of death: ICD-10 — M89.3 2 out of 7 registries used, show all original rules.	114
4. Check minimum number of events None	114
5. Include endpoints None	114
6. Filter based on genotype QC (FinnGen only)	114

Control definitions (FinnGen only)

Control exclude: M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M89
Name in latin: Hypertrophia ossis

NAME	M13_BONEHYPERTRPH
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M893
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M893
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypertrophy of bone based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	932	474	453
Only index persons	900	464	436
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	41.88	43.81	40.03
Only index persons	41.76	43.39	40.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	114	69	45
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	42.27	38.91	47.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M89.3

ICD-10 Finland

Hypertrophy of bone

+∞

145.6

101

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

216.2

18.1

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

76.9

17.4

N02BE01

ATC

paracetamol; systemic, rectal

5.0

6.5

706

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

418

1.92

2.93

4.0

3.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

172

2.01

2.53

1.4

1.2

11.9

31.6

iu/ml

1.55

(3019309) Folate [Moles/volume] in Red Blood Cells

129

2.09

2.40

1.6

1.5

984.7

1200.2

nmol/l

0.96

(3007853) Bacteria identified in Skin by Aerobe culture

2.30

2.38

3.1

1.5

—

(3002256) Pathology report gross observation

2.23

2.32

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.07

2.29

1.3

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

171

1.93

2.25

1.4

1.2

11.2

7.6

u/ml

0.14

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

3.17

2.20

1.4

1.6

34.3

37.3

nmol/l

—

(3042936) Bacteria identified in Isolate by Culture

111

2.09

2.19

2.3

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.79

2.07

9.4

6.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

717

1.81

1.98

3.1

3.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.09

1.93

1.4

1.5

—

(3037756) Immunofixation for Serum or Plasma

4.30

1.84

6.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

127

1.91

1.80

1.5

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.63

1.78

1.7

2.0

—

(3025941) Bacteria identified in Stool by Culture

2.43

1.76

1.2

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

3.04

1.75

1.0

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

263

1.67

1.70

2.9

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.00

1.67

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.03

1.65

6.4

19.6

1.2

1.3

inr

—

(3023368) Bacteria identified in Blood by Culture

194

1.66

1.46

4.0

3.6

—

(4010399)

2.12

1.44

2.2

1.4

—

(40768797) Stomach Pathology biopsy report

115

1.78

1.35

1.1

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

216

1.60

1.33

3.4

2.7

340.6

11374.0

umol/l

1.50

182

(3023511) Choriogonadotropin [Units/volume] in Urine

2.58

1.32

2.3

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

333

1.52

1.32

1.8

1.7

93.6

93.9

pmol/l

0.01

181

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.38

1.30

1.3

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.31

1.27

1.3

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

373

1.50

1.26

7.8

6.1

1.2

mmol/l

0.11

318

(3013826) Glucose [Moles/volume] in Serum or Plasma

519

1.48

1.23

6.7

3.9

6.9

6.7

mmol/l

0.09

481

(3025130) Human papilloma virus identified in Specimen

2.70

1.23

1.2

2.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.19

1.21

1.5

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.38

1.20

1.0

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

716

1.52

1.17

6.6

3.8

8.1

9.5

mm/h

1.06

657

(1616796) Gas panel - Central venous blood

2.57

1.16

2.4

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

233

1.52

1.13

5.4

3.2

0.0

estimate

0.00

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

199

1.54

1.10

2.3

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

430

1.43

1.08

4.5

3.1

0.0

estimate

0.00

(3008152) Bicarbonate [Moles/volume] in Arterial blood

2.08

1.08

4.8

7.8

25.2

23.5

mmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

623

1.42

1.00

5.8

3.6

—

(3026008) Bacteria identified in Urine by Culture

230

1.48

0.99

3.6

2.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.00

0.99

1.3

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

152

1.55

0.97

3.7

2.5

23.2

88.7

ng/l

0.83

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

103

960

1.76

0.96

16.0

10.6

22.1

20.5

mg/l

0.22

727

(3045414) Leukocytes [Presence] in Urine

1.95

0.96

2.0

1.5

—

(40758558) Short blood count panel - Blood

224

1.46

0.93

7.3

6.6

—

(3009261) Glucose [Presence] in Urine by Test strip

439

1.39

0.93

4.5

3.1

0.0

estimate

0.00

(3013650) Neutrophils [#/volume] in Blood by Automated count

547

1.39

0.93

12.3

9.4

4.3

4.0

e9/l

0.30

487

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.20

0.93

3.3

6.4

3.2

1.7

—

(3016502) Oxygen saturation in Arterial blood

1.77

0.93

9.3

6.9

97.2

95.8

0.84

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.73

0.92

9.2

6.3

4.8

5.0

kpa

0.26

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.97

0.91

1.3

1.2

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.92

0.89

3.1

1.3

47.1

41.9

u/l

—

(3018418) pH of Serum or Plasma

236

1.43

0.87

6.2

4.0

7.4

—

(3044889) 12 lead EKG panel

635

1.36

0.82

3.5

3.2

—

(3019060) Gas panel - Arterial blood

1.72

0.80

3.9

3.7

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.79

0.0

2.7

—

4.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.71

0.78

1.5

2.3

0.2

g/l

0.07

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.90

0.75

13.6

6.8

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.85

0.74

12.3

6.7

1.2

1.9

—

(3026782) Osmolality of Urine

153

1.46

0.74

3.1

2.3

573.1

585.3

mosm/kgh2o

0.10

130

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

110

1.53

0.73

2.0

1.8

—

(40761511) CBC panel - Blood by Automated count

107

1024

1.73

0.72

14.5

10.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.60

0.72

4.6

1.9

0.8

1.8

g/l

—

(40768804) Tissue Pathology biopsy report

376

1.33

0.71

2.4

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

190

1.40

0.71

4.1

3.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.89

0.69

1.6

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.89

0.69

1.2

1.4

—

(4034850)

1.82

0.67

5.8

6.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.64

0.63

1.5

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

241

1.33

0.61

2.0

1.9

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.61

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.60

0.0

1.1

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.60

0.0

1.2

—

5.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

151

1.39

0.59

2.0

2.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.56

0.59

1.6

1.4

—

(3008898) HLA-B27 [Presence]

1.52

0.58

1.0

1.1

—

(3006315) Basophils [#/volume] in Blood

473

1.27

0.58

10.8

5.6

0.0

e9/l

0.53

426

(3021601) Nitrite [Presence] in Urine by Test strip

435

1.27

0.56

5.5

4.3

0.0

estimate

0.00

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.54

0.56

2.4

4.4

58.8

82.6

ng/l

—

(3000991) Gas panel - Venous blood

1.54

0.56

11.4

6.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.54

0.56

1.2

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.61

0.55

10.3

4.7

23.4

24.4

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

138

1.36

0.49

1.7

—

(3001604) Monocytes [#/volume] in Blood

470

1.24

0.49

11.0

5.7

0.6

e9/l

0.04

422

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

116

0.67

0.49

1.8

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.43

0.48

4.2

5.9

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

101

966

1.40

0.48

16.1

11.7

3.9

mmol/l

0.33

933

(36304419) Bacteria [Presence] in Urine

231

1.28

0.47

3.8

2.4

—

(3012516) Albumin [Mass/volume] in Urine

241

1.27

0.46

3.1

2.9

21.5

71.2

mg/l

2.02

157

(3006504) Eosinophils/100 leukocytes in Blood

443

1.23

0.46

11.2

5.5

2.8

2.9

0.10

417

(3003694) ABO and Rh group [Type] in Blood

279

1.26

0.46

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

131

1.35

0.45

3.5

2.5

1.5

3.1

e6/l

0.77

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.42

0.44

1.8

1.9

—

(3019069) Monocytes/100 leukocytes in Blood

445

1.22

0.44

11.3

5.8

8.8

8.3

0.55

425

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

225

1.26

0.42

1.4

1.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

8.6

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.6

—

56.1

—

(3002582) Erythrocytes [#/volume] in Urine

254

1.25

0.41

4.1

2.6

8.6

36.6

e6/l

2.48

192

(3020682) Albumin/Creatinine [Ratio] in Urine

254

1.25

0.41

3.4

3.5

1.9

13.3

mg/mmol

2.67

161

(1761868) Lipid panel - Serum or Plasma

391

0.81

0.41

2.6

2.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

170

1.29

0.41

2.0

2.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

152

1.30

0.40

2.9

2.7

0.6

0.7

ug/l

0.42

(3017143) Hepatitis C virus Ab [Presence] in Serum

143

1.31

0.40

2.0

1.5

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.41

0.38

1.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.41

0.38

1.4

1.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.41

0.38

1.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.41

0.38

1.0

1.1

—

(3018095) Leukocytes [#/volume] in Urine

305

1.21

0.37

5.0

3.0

13.7

53.5

e6/l

1.31

204

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

334

1.21

0.37

4.9

3.1

—

(3022096) Basophils/100 leukocytes in Blood

432

1.19

0.36

11.6

5.4

0.7

0.08

406

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

296

1.21

0.36

2.3

3.1

13.2

41.6

ng/l

1.22

175

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

194

1.23

0.33

1.3

1.7

0.6

0.8

mg/l

0.70

148

(3030467) Casts [#/volume] in Urine by Automated count

232

1.21

0.32

3.7

2.6

0.1

0.5

e6/l

1.59

169

(42870588) Differential panel, method unspecified - Blood

300

1.19

0.31

10.4

5.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

139

1.26

0.31

3.3

2.4

0.5

0.8

e6/l

0.75

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.35

0.29

1.6

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

937

1.24

0.29

4.0

1.5

mmol/l

0.04

874

(3015736) pH of Urine

332

1.17

0.28

3.4

2.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

294

1.17

0.27

4.5

2.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.23

0.26

2.1

1.8

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.22

0.25

8.2

2.0

10.1

9.9

g/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

889

1.18

0.24

5.0

4.6

2.2

1.8

mu/l

1.36

824

(36660697) Celiac disease serology panel - Serum

0.74

0.23

1.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.26

0.22

2.0

1.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.26

0.22

1.4

2.7

—

(3013512) EKG study

229

0.85

0.22

3.7

3.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

202

1.17

0.22

4.7

4.0

21.5

22.9

0.15

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

105.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

4.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

11.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.27

0.21

4.7

2.8

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.7

—

60.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3022145) Colonoscopy Study observation

112

0.79

0.21

1.2

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

232

1.16

0.21

6.2

5.3

—

(4062490)

0.00

0.21

0.0

1.4

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

7.8

—

899.9

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

2.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

12.2

—

1644.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

194

1.17

0.20

2.0

1.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

214

1.15

0.19

2.5

1.4

2.0

2.4

g/l

0.63

126

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

914

1.16

0.19

4.6

4.0

5.7

5.9

mmol/l

0.86

853

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

904

1.16

0.19

15.0

10.2

86.7

87.3

ml/min/173m2

0.10

713

(3021589) Normoblasts [#/volume] in Blood

420

1.12

0.19

11.2

8.4

0.0

e9/l

0.50

342

(3041096) Erythrocytes [Presence] in Urine by Automated

244

1.14

0.18

4.4

2.9

—

(40761535) Cells panel - Urine sediment

1.19

0.17

4.3

3.1

—

(40761536) Microorganisms panel - Urine sediment

0.76

0.16

4.5

3.2

—

(3032080) INR in Blood by Coagulation assay

286

1.12

0.15

17.8

5.8

1.4

1.2

inr

0.60

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

189

1.14

0.15

1.8

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

104

1024

1.18

0.12

12.7

9.1

25.0

27.3

u/l

1.10

989

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

728

1.09

0.12

4.2

4.0

14.6

pmol/l

0.11

678

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.18

0.11

2.0

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

839

0.92

0.11

22.8

13.6

0.12

826

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

943

1.11

0.10

4.2

4.1

4.7

mmol/l

0.03

886

(3004588) Protein electrophoresis panel - Serum or Plasma

1.17

0.10

17.2

3.0

—

(3022621) pH of Urine by Test strip

1.12

0.09

6.3

1.9

—

(3000764) Benzodiazepines [Presence] in Urine

1.08

0.09

1.3

1.5

—

(3027008) Opiates [Presence] in Urine

1.08

0.09

1.3

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.08

0.09

1.3

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

113

0.87

0.09

1.7

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.06

0.08

1.3

1.5

—

(3017732) Neutrophils [#/volume] in Blood

1.10

0.08

2.7

2.4

3.7

3.9

e9/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.08

0.08

1.1

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

703

1.07

0.08

2.7

2.9

38.4

45.9

u/l

0.62

663

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

956

1.10

0.08

4.8

4.4

2.8

mmol/l

0.15

889

(3019225) pH of Specimen

1.03

0.08

1.3

3.8

—

(3000494) Fungus identified in Specimen by Culture

101

1.10

0.04

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

919

0.95

0.03

17.5

11.5

40.9

40.5

0.24

712

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

718

1.01

0.00

9.1

6.6

71.0

75.7

u/l

0.73

663

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

916

1.02

0.00

3.8

3.6

1.3

mmol/l

0.22

854

(21494755) Public health laboratory ask at order entry panel

119

1.01

0.00

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

276.6

—

(40758355) Pancreatic polypeptide [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

57.3

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.2

—

1.7

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.0

—

87.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.8

—

90.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.8

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

124.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.0

—

12.5

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

6.8

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.90

0.00

1.8

1.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3012544) pH of Venous blood

0.90

0.00

2.5

3.8

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.92

0.00

1.4

1.5

369.4

324.6

mu/l

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

12.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.8

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.00

0.00

2.8

5.8

—

0.4

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.3

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

36.8

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

106.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(4035726)

0.99

0.00

1.1

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

0.8

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

0.5

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.5

—

1.7

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.97

0.00

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_BONEHYPERTRPH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_BONEHYPERTRPH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_BONEHYPERTRPH – Hypertrophy of bone

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypertrophy of bone

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints