Hypertrophy of bone

M13_BONEHYPERTRPH

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M89.3 Cause of death: ICD-10 — M89.3 2 out of 7 registries used, show all original rules.	118
4. Check minimum number of events None	118
5. Include endpoints None	118
6. Filter based on genotype QC (FinnGen only)	115

Control definitions (FinnGen only)

Control exclude: M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M89
Name in latin: Hypertrophia ossis

NAME	M13_BONEHYPERTRPH
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M893
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M893
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypertrophy of bone based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	932	474	453
Only index persons	900	464	436
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	41.88	43.81	40.03
Only index persons	41.76	43.39	40.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	115	71	44
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	44.49	42.82	47.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
118: Matched controls
1180

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M89.3

ICD-10 Finland

Hypertrophy of bone

+∞

170.3

118

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

224.2

19.1

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

26.4

14.8

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

4.8

8.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

435

2.03

3.50

2.7

2.3

—

(3002256) Pathology report gross observation

2.50

3.31

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.38

2.68

3.1

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

178

2.01

2.60

1.6

1.2

30.71

31.55

iu/ml

0.01

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

180

1.98

2.51

1.5

1.2

9.65

7.17

u/ml

0.11

(3019309) Folate [Moles/volume] in Red Blood Cells

130

2.06

2.34

1.6

1.5

984.67

1187.39

nmol/l

0.89

(3042936) Bacteria identified in Isolate by Culture

116

2.10

2.30

2.3

1.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

2.31

2.20

1.8

2.5

10.49

14.55

nmol/l

1.55

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

3.16

2.20

1.4

1.6

34.33

37.30

nmol/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.65

2.09

1.3

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.71

1.99

9.4

6.0

—

(40768797) Stomach Pathology biopsy report

117

1.97

1.90

1.1

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

275

1.69

1.84

2.9

2.1

—

(3037756) Immunofixation for Serum or Plasma

4.30

1.84

6.8

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.01

1.78

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

747

1.70

1.71

3.1

3.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

534

1.59

1.67

6.4

3.9

6.83

6.65

mmol/l

0.12

493

(3029937) Albumin [Presence] in Urine by Test strip

238

1.67

1.66

5.6

3.1

0.00

estimate

-0.00

(3023511) Choriogonadotropin [Units/volume] in Urine

2.80

1.60

2.3

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

384

1.58

1.60

7.6

6.2

1.22

mmol/l

0.06

328

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

132

1.82

1.60

1.5

1.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

225

1.65

1.54

3.4

2.7

336.79

10851.72

umol/l

1.50

191

(3015171) Extractable nuclear Ab [Units/volume] in Serum

2.69

1.54

1.0

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.92

1.53

1.5

1.4

—

(3023368) Bacteria identified in Blood by Culture

200

1.67

1.53

3.9

3.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.55

1.51

1.7

2.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

353

1.55

1.47

14.0

9.5

1.24

1.19

inr

0.14

110

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.35

1.43

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

2.19

1.43

1.2

—

(4200892) Spirometry reversibility

2.08

1.38

2.2

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

341

1.52

1.33

1.8

1.7

96.12

94.75

pmol/l

0.06

184

(3026008) Bacteria identified in Urine by Culture

243

1.56

1.30

3.7

2.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.85

1.30

3.0

3.6

3.74

3.95

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

448

1.48

1.26

4.7

3.1

0.00

0.01

estimate

0.49

(3018418) pH of Serum or Plasma

237

1.54

1.23

6.1

4.0

7.40

—

(3013707) Erythrocyte sedimentation rate by Westergren method

742

1.52

1.21

6.5

3.8

7.85

9.51

mm/h

1.34

683

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.38

1.20

1.0

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.13

1.18

1.3

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.13

1.18

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.13

1.18

1.3

1.4

—

(1616796) Gas panel - Central venous blood

2.56

1.16

2.4

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

455

1.44

1.13

4.7

3.1

0.00

estimate

-0.00

(3037467) Urinalysis macro (dipstick) panel - Urine

644

1.45

1.12

5.7

3.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

566

1.43

1.08

12.0

9.4

4.22

3.96

e9/l

0.31

503

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

209

1.51

1.06

2.4

2.1

—

(3025130) Human papilloma virus identified in Specimen

2.33

1.04

1.2

2.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

107

997

1.79

1.02

15.8

10.6

22.03

20.49

mg/l

0.21

757

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

159

1.55

1.01

3.8

2.5

21.87

93.30

ng/l

1.00

(40758558) Short blood count panel - Blood

229

1.48

1.01

7.1

6.7

—

(3044889) 12 lead EKG panel

651

1.42

1.01

3.5

3.2

—

(3045414) Leukocytes [Presence] in Urine

1.95

0.95

2.0

1.5

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.20

0.93

3.3

6.4

3.23

1.63

—

(3016502) Oxygen saturation in Arterial blood

1.77

0.93

9.3

7.0

97.24

95.83

0.85

(3024561) Albumin [Mass/volume] in Serum or Plasma

355

1.38

0.88

6.2

3.9

36.14

36.58

g/l

0.27

336

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.88

0.88

3.1

1.4

47.10

41.13

u/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.68

0.85

9.2

6.5

4.82

4.99

kpa

0.28

(3026782) Osmolality of Urine

157

1.49

0.84

3.0

2.5

595.06

581.78

mosm/kgh2o

0.10

134

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.79

0.84

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

202

1.44

0.82

1.3

1.7

0.52

0.83

mg/l

1.01

156

(3019060) Gas panel - Arterial blood

1.75

0.82

3.9

3.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.66

0.82

11.0

6.4

105.85

104.13

mmol/l

0.91

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.80

0.0

2.8

—

4.47

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.22

0.77

1.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.72

0.76

1.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.68

0.74

1.5

2.3

0.23

0.22

g/l

0.04

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.84

0.74

13.6

7.2

0.74

0.66

—

(40768804) Tissue Pathology biopsy report

393

1.33

0.73

2.4

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

451

1.32

0.73

5.7

4.3

0.00

estimate

-0.00

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.80

0.72

12.3

7.1

1.20

1.85

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

198

1.40

0.72

4.7

3.0

—

(40761511) CBC panel - Blood by Automated count

111

1063

1.74

0.72

14.3

10.0

—

(3008898) HLA-B27 [Presence]

1.60

0.71

1.0

1.1

—

(3006315) Basophils [#/volume] in Blood

492

1.31

0.70

10.5

5.5

0.04

e9/l

0.50

442

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.89

0.69

1.2

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.76

0.64

1.4

—

(4034850) Laboratory test

1.70

0.62

5.8

—

(3003694) ABO and Rh group [Type] in Blood

287

1.31

0.62

1.5

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.61

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.60

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

345

1.29

0.60

5.2

3.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

105

998

1.47

0.60

15.9

11.6

3.93

3.94

mmol/l

0.30

966

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.2

—

5.09

—

(3001604) Monocytes [#/volume] in Blood

491

1.27

0.59

10.7

5.5

0.55

e9/l

0.04

440

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.50

0.58

1.8

1.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.54

0.58

1.6

1.4

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.57

0.56

4.6

1.8

0.81

1.76

g/l

—

(3012516) Albumin [Mass/volume] in Urine

244

1.31

0.56

3.0

2.9

21.48

60.19

mg/l

1.76

161

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.51

0.55

2.4

4.4

58.78

79.35

ng/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.49

0.54

1.2

1.3

—

(36304419) Bacteria [Presence] in Urine

236

1.30

0.54

3.7

2.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

236

1.30

0.54

1.4

1.6

—

(3000991) Gas panel - Venous blood

1.46

0.54

11.3

6.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

118

1.41

0.53

2.0

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

466

1.25

0.53

9.8

6.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.53

0.52

10.3

5.1

23.35

24.45

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

137

1.37

0.51

3.4

2.5

1.45

3.15

e6/l

0.82

(3020682) Albumin/Creatinine [Ratio] in Urine

257

1.28

0.50

3.3

3.4

1.87

11.78

mg/mmol

2.41

164

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

120

0.64

0.48

1.8

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

306

1.25

0.48

2.3

3.0

13.22

41.13

ng/l

1.21

177

(3002582) Erythrocytes [#/volume] in Urine

261

1.25

0.44

4.1

2.6

8.50

36.43

e6/l

2.52

195

(46235355) HIV 1 and 2 tests - Meaningful Use set

252

1.26

0.44

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.40

0.44

4.2

5.8

—

(1761868) Lipid panel - Serum or Plasma

404

0.81

0.43

2.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.59

0.43

1.6

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

160

1.30

0.42

2.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

8.53

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

0.92

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

1.29

—

(3018095) Leukocytes [#/volume] in Urine

311

1.23

0.41

4.9

3.1

13.66

53.04

e6/l

1.31

206

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

0.26

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.4

—

53.41

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

152

1.30

0.40

2.9

2.8

0.62

0.67

ug/l

0.25

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.41

0.40

1.5

—

(3018010) Neutrophils/100 leukocytes in Blood

468

1.20

0.39

10.7

5.3

55.97

56.82

0.22

447

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

304

1.22

0.38

4.3

2.6

—

(40761535) Cells panel - Urine sediment

1.29

0.37

5.0

3.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

145

1.28

0.36

3.2

2.4

0.45

0.80

e6/l

0.75

(3002030) Lymphocytes/100 leukocytes in Blood

471

1.19

0.36

10.9

5.5

30.07

28.94

0.36

451

(3021589) Normoblasts [#/volume] in Blood

432

1.19

0.36

10.9

8.2

0.00

e9/l

0.50

350

(3030467) Casts [#/volume] in Urine by Automated count

239

1.22

0.36

3.7

2.6

0.08

0.49

e6/l

1.62

172

(3006504) Eosinophils/100 leukocytes in Blood

463

1.18

0.34

11.0

5.4

2.82

2.90

0.09

438

(3019832) Treponema pallidum Ab [Presence] in Serum

147

1.26

0.33

1.7

—

(3013512) EKG study

238

0.81

0.32

3.8

3.4

—

(3019069) Monocytes/100 leukocytes in Blood

465

1.17

0.32

11.1

5.7

8.84

8.31

0.57

444

(3041096) Erythrocytes [Presence] in Urine by Automated

252

1.20

0.31

4.2

2.9

—

(3022621) pH of Urine by Test strip

1.31

0.31

5.7

2.0

—

(3022145) Colonoscopy Study observation

116

0.76

0.29

1.2

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

150

1.24

0.28

2.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

887

0.85

0.28

5.7

5.0

39.62

39.23

mmol/mol

0.12

841

(3022096) Basophils/100 leukocytes in Blood

450

1.15

0.27

11.4

5.3

0.74

0.72

0.11

423

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

179

1.21

0.27

2.0

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.33

0.27

2.0

1.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

937

1.20

0.26

14.7

10.1

87.25

87.81

ml/min/173m2

0.09

748

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

917

1.18

0.25

5.2

4.6

2.15

1.84

mu/l

1.29

851

(3005719) IgG [Mass/volume] in Serum or Plasma

1.18

0.25

8.2

2.0

10.08

9.97

g/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.37

0.24

1.4

1.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.33

0.23

1.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.33

0.23

1.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.33

0.23

1.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.26

0.22

2.0

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

202

1.17

0.22

4.7

4.0

21.46

22.54

0.11

(3004588) Protein electrophoresis panel - Serum or Plasma

1.20

0.22

17.2

3.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.20

0.22

1.4

2.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

11.72

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.1

—

4.04

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.1

—

104.40

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

222

1.16

0.21

2.4

1.4

2.02

2.34

g/l

0.59

131

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.7

—

60.17

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

100

973

1.18

0.21

4.1

4.0

1.48

1.47

mmol/l

0.06

911

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

2.57

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

12.1

—

1703.36

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

7.9

—

923.43

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

1.58

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.26

0.19

4.7

2.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

205

1.15

0.19

2.0

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

946

1.14

0.17

4.7

4.0

5.69

5.85

mmol/l

0.85

882

(40761536) Microorganisms panel - Urine sediment

0.76

0.16

4.5

3.2

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

108

1062

1.20

0.15

12.7

9.1

24.88

27.34

u/l

1.24

103

1025

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

199

1.13

0.14

1.7

1.4

—

(36660697) Celiac disease serology panel - Serum

0.80

0.14

1.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.19

0.13

1.9

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

747

1.09

0.13

4.4

4.0

14.57

14.62

pmol/l

0.06

695

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

728

1.08

0.12

2.6

2.9

37.59

46.31

u/l

0.79

687

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

252

1.09

0.10

1.3

18.78

1.18

u/ml

—

(3000494) Fungus identified in Specimen by Culture

106

1.15

0.10

1.4

—

(1002224) Polysomnography panel

0.83

0.08

1.8

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.12

0.08

1.0

—

(3017732) Neutrophils [#/volume] in Blood

1.06

0.08

2.7

2.3

3.74

13.38

e9/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.05

0.08

1.1

1.3

—

(3012544) pH of Venous blood

1.03

0.08

2.3

3.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

121

0.90

0.06

1.6

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

979

1.07

0.05

4.2

4.0

4.75

4.76

mmol/l

0.05

922

(21494755) Public health laboratory ask at order entry panel

128

0.93

0.03

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

100

992

1.05

0.02

4.9

4.4

2.80

2.86

mmol/l

0.30

926

(3002385) Erythrocyte distribution width [Ratio]

892

1.04

0.02

21.5

13.3

15.26

14.49

0.51

880

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

744

1.02

0.00

8.9

6.6

70.80

75.42

u/l

0.73

689

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

948

1.01

0.00

3.8

3.6

1.34

1.31

mmol/l

0.13

885

(3000764) Benzodiazepines [Presence] in Urine

1.00

0.00

1.3

1.5

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.2

—

1.74

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.0

—

87.60

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(3027008) Opiates [Presence] in Urine

1.00

0.00

1.3

1.5

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

67.80

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.8

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.0

—

210.92

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

14.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

1126.00

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(40758355) Pancreatic polypeptide [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

57.30

—

(3028300) Cannabinoids [Presence] in Urine

1.00

0.00

1.3

1.5

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

124.40

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

7.76

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3019225) pH of Specimen

0.97

-0.00

1.3

4.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(4035726) Immunohistochemistry procedure

0.95

-0.00

1.1

1.3

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

1.54

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

253.61

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.6

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

1.67

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.8

—

90.15

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

0.83

—

(3027944) Amphetamines [Presence] in Urine

0.98

-0.00

1.3

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

0.50

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.89

-0.00

1.4

1.5

369.40

323.28

mu/l

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.0

—

12.54

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

106.71

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3017354) Segmented neutrophils/100 leukocytes in Blood

0.00

-0.00

0.0

2.7

—

63.29

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

33.48

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_BONEHYPERTRPH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_BONEHYPERTRPH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_BONEHYPERTRPH – Hypertrophy of bone

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypertrophy of bone

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints