Bacterial sepsis of newborn

P16_BACTERIAL_SEPSIS_NEWBO

bacteriemia: An infectious disease caused by bacteria causing sepsis.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P36 Cause of death: ICD-10 — P36 2 out of 7 registries used, show all original rules.	213
4. Check minimum number of events None	213
5. Include endpoints None	213
6. Filter based on genotype QC (FinnGen only)	213

Control definitions (FinnGen only)

Control exclude: P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P3
Name in latin: Sepsis bacterialis neonatorum

NAME	P16_BACTERIAL_SEPSIS_NEWBO
CONTROL_EXCLUDE	P16_INFECTIONS_SPECIFIC_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P36
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P36
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Bacterial sepsis of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	26986	11234	15752
Only index persons	10206	4214	5992
Unadjusted period prevalence (%)
Whole population	0.39	0.32	0.44
Only index persons	0.20	0.15	0.23
Median age at first event (years)
Whole population	-	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	213	124	89
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
185: Matched controls
1850

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P36.90

ICD-10 Finland

Suspected bacterial sepsis of newborn

+∞

159.2

129

P36.0

ICD-10 Finland

Sepsis of newborn due to streptococcus, group B

+∞

21.2

P36.99

ICD-10 Finland

Bacterial sepsis of newborn, unspecified

+∞

20.2

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

7.7

18.0

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

18.6

11.4

P07.3

ICD-10 Finland

Other preterm infants

5.4

10.7

P36.3

ICD-10 Finland

Sepsis of newborn due to other and unspecified staphylococci

+∞

10.5

P39.9

ICD-10 Finland

Infection specific to the perinatal period, unspecified

+∞

7.3

P01.10

ICD-10 Finland

Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery

12.9

6.7

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

3.58

4.26

4.0

4.5

27.9

22.3

umol/l

0.88

(3001186) Copper [Moles/volume] in Serum or Plasma

8.77

3.28

1.2

1.0

17.6

21.9

umol/l

—

(3020891) Body temperature

3.35

3.10

3.7

6.7

—

(3019225) pH of Specimen

2.75

3.03

1.9

3.8

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

4.48

2.49

1.0

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

5.10

2.41

1.2

1.3

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

5.10

2.41

1.2

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.71

2.28

1.2

—

(3023368) Bacteria identified in Blood by Culture

288

1.66

2.21

5.9

4.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

355

1.57

2.00

4.0

4.3

4.5

2.6

e6/l

0.29

212

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

461

1.52

1.97

3.5

3.6

2.7

2.6

mg/l

0.03

409

(3005719) IgG [Mass/volume] in Serum or Plasma

211

1.67

1.81

3.4

5.0

7.8

8.7

g/l

0.59

203

(3009508) Creatinine [Moles/volume] in Urine

398

1.51

1.80

3.3

5.3

8.1

8.4

mmol/l

0.14

375

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

349

1.52

1.73

4.2

4.1

0.3

0.7

e6/l

1.57

205

(3011397) Hemoglobin [Presence] in Urine by Test strip

403

1.49

1.70

3.9

3.4

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

2.64

1.67

1.6

2.4

12.1

umol/l

—

(4034850)

3.21

1.67

8.5

5.6

—

(3002256) Pathology report gross observation

106

1.87

1.64

1.0

1.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

1.54

0.0

3.6

—

3.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.38

1.53

1.4

1.2

—

(3012516) Albumin [Mass/volume] in Urine

132

1.74

1.52

2.7

3.9

41.9

131.8

mg/l

1.00

112

(40761535) Cells panel - Urine sediment

2.06

1.52

4.5

3.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.03

1.46

3.1

4.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

191

1.60

1.44

1.6

1.3

18.5

18.8

nmol/l

0.04

165

(3000494) Fungus identified in Specimen by Culture

135

1.70

1.42

1.7

2.3

—

(3027653) Mycophenolate [Mass/volume] in Serum or Plasma

2.46

1.40

5.1

8.4

2.3

1.6

mg/l

—

(40768446) Kidney Pathology biopsy report

2.46

1.40

2.6

—

(4035726)

1.89

1.39

2.1

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.89

1.39

2.5

2.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.65

1.37

1.0

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

532

1.38

1.32

8.3

9.5

25.8

26.7

umol/l

0.05

486

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

187

1.57

1.32

2.9

2.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

131

1.67

1.29

3.0

4.5

0.5

12.1

mg/mmol

1.80

111

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

108

1.73

1.26

2.8

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

189

1.55

1.26

2.6

2.2

—

(3022313) Gas panel - Capillary blood

399

1.40

1.25

11.2

10.3

—

(3010015) Selenium [Moles/volume] in Serum or Plasma

2.67

1.22

1.6

2.4

0.9

1.1

umol/l

—

(3000991) Gas panel - Venous blood

410

1.39

1.21

9.7

11.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

358

1.40

1.18

4.6

3.5

—

(3023520) Reticulocytes [#/volume] in Blood

184

1.53

1.17

5.3

4.9

64.4

60.3

e9/l

0.22

113

(3029634) Reagin Ab [Titer] in Serum by VDRL

2.09

1.16

1.6

1.3

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

2.53

1.15

1.0

1.1

—

(21494434) Karyotype in Bone marrow

2.53

1.15

1.4

1.5

—

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.53

1.15

9.6

7.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

228

1.47

1.14

2.9

2.2

—

(40768441) Liver Pathology biopsy report

2.41

1.09

2.0

2.3

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

2.22

1.09

2.3

2.4

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

2.22

1.09

1.1

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

2.04

1.06

2.6

6.5

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

2.30

1.04

1.2

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

1.93

1.03

2.5

1.8

—

(44790048)

1.81

1.02

2.8

2.4

—

(44806118)

1.81

1.02

2.8

2.4

—

(44790047)

1.81

1.02

2.8

2.4

—

(44790049)

1.81

1.02

2.8

2.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.71

1.00

2.1

2.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

184

0.58

0.98

1.3

1.2

—

16.3

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

1.89

0.98

2.7

6.3

93.6

97.6

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.98

0.0

1.0

—

(40761511) CBC panel - Blood by Automated count

176

1651

1.37

0.97

11.3

8.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

603

1.29

0.96

5.2

5.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

398

1.33

0.96

3.3

2.7

2.4

mmol/l

0.00

362

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.96

0.0

2.5

—

26.2

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.96

0.0

1.1

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

1.81

0.96

5.0

7.0

520.6

454.1

mg/l

0.15

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

1.81

0.96

1.7

2.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

102

894

1.27

0.94

7.2

5.3

142.2

136.6

u/l

0.22

841

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.25

0.94

8.0

11.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.76

0.93

1.9

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

672

1.28

0.93

3.7

3.6

0.0

estimate

—

110

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.67

0.93

2.7

2.4

—

(3015736) pH of Urine

540

1.29

0.92

3.8

3.4

—

(3009261) Glucose [Presence] in Urine by Test strip

676

1.27

0.88

3.6

3.7

0.0

estimate

—

117

(3019060) Gas panel - Arterial blood

2.03

0.87

9.0

1.8

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

2.03

0.87

1.2

1.4

—

(3002032) Base excess in Venous blood by calculation

450

1.30

0.87

9.8

10.2

-0.4

1.2

mmol/l

1.25

340

(4010399)

1.60

0.86

1.4

1.5

—

(3016879) Cocaine [Presence] in Urine

198

1.41

0.85

1.1

1.9

—

(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence

1.96

0.85

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

1.96

0.85

7.2

5.2

—

(44813793)

1.96

0.85

1.0

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

1.96

0.85

4.3

6.3

—

(3030467) Casts [#/volume] in Urine by Automated count

536

1.28

0.85

5.3

4.9

0.2

0.3

e6/l

0.43

402

(3000093) Morphology [Interpretation] in Blood Narrative

1.90

0.82

1.2

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

1.90

0.82

2.8

1.9

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

454

1.28

0.81

14.4

10.4

1.1

0.9

mmol/l

0.14

321

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

136

1246

1.25

0.81

3.5

3.3

14.2

14.4

pmol/l

0.29

127

1134

(3044889) 12 lead EKG panel

633

0.78

0.80

2.4

2.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(3016038) Potassium [Moles/volume] in Urine

1.84

0.79

4.2

2.1

50.0

38.0

mmol/l

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.79

0.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

674

1.25

0.79

5.9

5.2

0.0

estimate

—

118

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.79

0.0

1.0

—

(3009343) pH of Capillary blood

456

1.28

0.79

14.5

10.4

—

7.4

—

(3019150) Specific gravity of Urine by Refractometry

345

1.31

0.78

2.6

3.1

1.0

kg/l

2.07

(40758558) Short blood count panel - Blood

647

1.24

0.77

7.7

10.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

796

0.80

0.77

13.5

6.8

109.9

112.3

ml/min/173m2

0.27

487

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

1.78

0.77

3.0

—

(3028300) Cannabinoids [Presence] in Urine

211

1.38

0.76

1.4

1.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.73

0.76

1.3

3.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.68

0.76

1.4

2.3

—

(3024928) Oxygen saturation in Venous blood

1.69

0.75

20.7

11.4

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

2.11

0.75

8.4

6.8

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

2.11

0.75

8.4

6.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.11

0.75

2.4

1.5

—

(40761536) Microorganisms panel - Urine sediment

110

0.53

0.74

1.7

3.9

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

158

0.61

0.74

1.5

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

158

0.61

0.74

1.1

1.2

—

(3023410) Appearance of Cerebral spinal fluid

1.63

0.73

6.1

7.3

—

(3045142) Bone marrow Pathology biopsy report

2.02

0.73

1.4

1.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

423

1.27

0.73

2.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

914

0.82

0.72

2.0

2.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

146

0.60

0.72

1.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.77

0.72

1.4

1.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

170

1.39

0.71

1.8

2.4

1.0

g/l

0.03

162

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.73

0.70

2.9

1.5

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

1.87

0.69

1.0

1.1

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

1.87

0.69

2.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

400

1.26

0.66

2.4

—

(36304419) Bacteria [Presence] in Urine

542

1.23

0.66

5.1

4.8

—

(3051651) Icteric interference index of Serum or Plasma

1.74

0.64

8.2

5.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

105

0.56

0.63

1.5

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

412

1.24

0.63

4.9

3.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

255

1.30

0.62

5.0

6.3

9.2

1.8

mg/l

0.53

186

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.60

0.0

2.5

—

(3027008) Opiates [Presence] in Urine

211

1.32

0.60

1.3

1.9

—

(3000764) Benzodiazepines [Presence] in Urine

211

1.32

0.60

1.3

1.9

—

(3020393) Adenovirus Ag [Presence] in Stool

1.56

0.60

1.3

2.3

—

(3002582) Erythrocytes [#/volume] in Urine

576

1.21

0.60

5.2

5.0

27.5

23.9

e6/l

0.07

440

(42870588) Differential panel, method unspecified - Blood

868

1.19

0.59

8.9

10.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.58

0.0

1.2

—

(3018095) Leukocytes [#/volume] in Urine

664

1.20

0.58

6.4

5.8

27.9

62.7

e6/l

0.68

454

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

1.50

0.58

1.1

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

881

1.18

0.56

2.7

2.2

5.5

5.3

mmol/l

0.76

792

(3044290) Cell count panel - Cerebral spinal fluid

1.55

0.55

6.0

6.9

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

1.59

0.54

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

1.49

0.54

1.4

2.4

—

(3032080) INR in Blood by Coagulation assay

335

1.24

0.53

8.0

4.3

1.1

inr

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

439

1.21

0.53

2.6

3.4

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

1.45

0.53

2.7

4.8

27.0

26.5

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

144

1.35

0.52

2.7

2.0

176.4

175.3

u/ml

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

123

1146

1.17

0.51

11.0

11.7

3.0

3.3

e9/l

0.97

100

948

(3027944) Amphetamines [Presence] in Urine

209

1.28

0.49

1.3

1.9

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.54

0.49

10.0

3.1

663.4

276.0

ug/l

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

146

1.33

0.48

2.7

2.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

837

0.86

0.48

1.8

1.9

1.3

3.6

u/ml

1.17

144

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

425

1.20

0.47

9.5

9.7

22.8

23.6

mmol/l

1.19

413

(3024891) Influenza virus A+B Ag [Presence] in Specimen

120

1.36

0.47

1.2

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

263

0.78

0.47

2.1

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

165

1.30

0.47

1.3

1.9

—

(3011288) Drugs identified in Urine by Screen method

156

1.31

0.47

1.3

2.4

—

(3001604) Monocytes [#/volume] in Blood

117

1092

1.16

0.46

8.1

10.1

0.6

e9/l

0.09

898

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

314

1.21

0.45

1.9

1.4

99.2

96.1

pmol/l

0.12

160

(3022217) INR in Platelet poor plasma by Coagulation assay

1.38

0.44

3.1

8.7

—

1.1

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.38

0.44

12.7

11.6

73.9

71.9

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.57

0.42

1.0

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.57

0.42

3.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

223

1.24

0.42

2.0

1.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.53

0.41

1.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

5.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

336.1

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.41

0.0

1.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

2.1

—

4.9

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.41

0.0

2.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

101

0.68

0.40

1.9

2.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.40

0.0

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

262

1.21

0.39

1.1

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.39

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.38

0.39

1.0

1.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.38

0.39

1.0

1.3

—

(1175426) CD3 cells/100 lymphocytes in Blood

1.36

0.38

2.7

4.8

69.7

66.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.36

0.38

1.0

1.2

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

1.40

0.38

2.4

4.0

508.8

420.6

umol/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.34

0.38

1.2

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

146

1395

1.15

0.37

4.2

3.6

2.0

mu/l

0.39

140

1307

(3006245) CD3-CD19+ cells/100 cells in Blood

1.41

0.37

2.8

4.9

13.2

18.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

102

953

1.13

0.37

4.5

4.0

—

76.1

—

(3006315) Basophils [#/volume] in Blood

116

1093

1.13

0.37

8.2

10.1

0.0

e9/l

0.14

898

(3034770) Mitochondria Ab [Titer] in Serum

1.48

0.36

1.2

2.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

1.48

0.36

1.3

2.9

—

54.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

247

1.20

0.35

3.1

1.9

—

(3000492) Spirometry study

100

1.32

0.34

1.8

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

183

1781

1.19

0.34

3.9

—

(3019198) Lymphocytes [#/volume] in Blood

118

1117

1.12

0.34

8.1

10.0

2.5

2.4

e9/l

0.41

103

949

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.31

0.33

4.2

2.8

17.1

7.3

ug/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.37

0.33

1.5

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.37

0.33

4.6

2.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.28

0.32

2.5

1.7

—

(3013115) Eosinophils [#/volume] in Blood

117

1109

1.12

0.32

9.6

10.9

0.2

e9/l

0.56

101

938

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.33

0.31

1.4

1.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

174

1691

1.15

0.30

15.0

11.6

23.3

24.2

mg/l

0.14

121

1140

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.26

0.29

1.0

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.26

0.29

3.9

2.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

501

1.13

0.29

16.5

13.7

24.5

24.7

mmol/l

0.25

501

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

1.23

0.29

2.1

1.5

—

(3007461) Platelets [#/volume] in Blood

196

1924

1.22

0.28

22.9

16.7

283.1

274.8

e9/l

0.81

188

1826

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.28

0.28

14.2

14.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

187

1.20

0.27

7.0

3.7

712.0

1093.9

ng/l

—

114

(3019832) Treponema pallidum Ab [Presence] in Serum

245

0.84

0.27

1.8

1.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

273

1.16

0.26

2.2

1.8

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.69

0.26

1.2

1.1

—

3.8

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.67

0.26

1.0

1.4

—

(3022145) Colonoscopy Study observation

1.26

0.26

1.6

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.26

0.26

12.3

14.8

90.1

95.3

—

(40768797) Stomach Pathology biopsy report

123

1.23

0.26

1.8

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

303

1.14

0.25

2.0

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

555

1.11

0.25

1.9

2.0

—

(3026361) Erythrocytes [#/volume] in Blood

196

1927

1.20

0.25

22.8

16.6

4.6

e12/l

0.01

188

1820

(3010813) Leukocytes [#/volume] in Blood

196

1928

1.20

0.24

22.8

16.7

6.8

6.9

e9/l

0.41

188

1822

(3009214) Lutropin [Units/volume] in Serum or Plasma

162

1.19

0.23

2.1

2.6

5.8

5.4

u/l

0.12

105

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

134

1.21

0.23

2.1

1.9

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

1.25

0.22

2.4

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

124

0.80

0.22

2.3

1.5

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

3.8

—

(3030313) Adrenal Ab [Titer] in Serum

0.00

0.21

0.0

1.4

—

(3020485) Acetaminophen [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

5.2

—

360.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3001820) Epstein Barr virus nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

126

1.20

0.21

1.3

1.4

630.3

58261321.1

pmol/l

0.50

115

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

302

0.88

0.21

2.0

2.1

—

(3040893) Potassium [Moles/volume] in Capillary blood

0.00

0.21

0.0

5.2

—

4.5

—

(3007302) Hemoglobin [Mass/volume] in Mixed venous blood

0.00

0.21

0.0

1.7

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

144

0.82

0.20

1.7

2.6

4.4

7.0

iu/l

—

(1001833) Epstein Barr virus DNA [Units/volume] (viral load) in Blood by NAA with probe detection

0.00

0.20

0.0

5.9

—

(40768804) Tissue Pathology biopsy report

309

0.89

0.18

1.7

1.6

—

(3000850) Epithelial cells [#/volume] in Urine

381

0.90

0.18

4.2

3.8

6.6

8.3

e6/l

0.34

335

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.23

0.17

1.3

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.23

0.17

1.3

1.5

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

1.18

0.17

2.8

4.8

—

(3013512) EKG study

172

0.86

0.16

3.1

2.7

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.79

0.15

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.78

0.15

1.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

103

1.17

0.14

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

106

0.84

0.13

1.2

1.3

—

(3003694) ABO and Rh group [Type] in Blood

503

1.07

0.13

1.8

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

191

1.11

0.12

4.3

2.6

31.6

19.0

ng/l

—

(36660697) Celiac disease serology panel - Serum

357

1.08

0.12

1.3

1.2

—

(1761868) Lipid panel - Serum or Plasma

231

1.09

0.11

1.9

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

421

0.94

0.10

2.0

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

184

1.09

0.09

1.2

0.4

1.0

u/ml

0.81

142

(3024980) IgG subclass 4 [Mass/volume] in Serum

1.13

0.09

1.5

1.7

1.1

0.6

g/l

—

(3035933) Granulocytes/100 leukocytes in Blood

1.07

0.08

1.7

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.81

0.08

2.4

1.3

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

185

1.09

0.08

1.2

10.6

7.0

u/ml

0.26

145

(3052851) Hemolysis interference index of Serum or Plasma

1.06

0.08

6.4

3.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.03

0.08

1.7

1.2

—

(3022621) pH of Urine by Test strip

0.80

0.07

4.0

1.8

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.08

0.07

13.1

14.4

0.8

0.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.84

0.07

1.7

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

552

1.04

0.07

6.2

4.4

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

139

1.08

0.05

4.8

2.8

30.3

33.6

u/l

—

108

(3009542) Hematocrit [Volume Fraction] of Blood

175

1760

0.96

0.04

22.0

15.1

38.7

38.9

0.27

157

1573

(3026008) Bacteria identified in Urine by Culture

400

0.97

0.03

3.4

2.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

341

1.03

0.02

5.0

5.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.08

0.02

1.8

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

786

0.99

0.01

1.8

1.3

1.5

g/l

0.70

390

(3029937) Albumin [Presence] in Urine by Test strip

326

0.98

0.01

2.8

3.9

0.0

estimate

—

114

(3021387) Prolactin [Units/volume] in Serum or Plasma

114

1.05

0.00

1.4

1.5

280.6

363.6

mu/l

0.60

109

(3003327) Ova and parasites identified in Stool by Light microscopy

114

1.05

0.00

2.1

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

983

1.01

0.00

5.3

4.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

168

1.01

0.00

1.8

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

111

0.99

0.00

1.3

2.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

315

1.02

0.00

2.2

3.2

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

197

1.02

0.00

1.3

2.0

3.6

u/ml

0.41

136

(3013826) Glucose [Moles/volume] in Serum or Plasma

867

1.00

0.00

12.3

7.6

6.4

6.1

mmol/l

0.63

815

(3021589) Normoblasts [#/volume] in Blood

104

1036

1.01

0.00

8.8

11.6

0.0

e9/l

0.47

773

(3013707) Erythrocyte sedimentation rate by Westergren method

106

1054

1.01

0.00

4.2

4.7

8.8

7.3

mm/h

0.51

100

982

(3048689) Calprotectin [Mass/mass] in Stool

391

1.00

0.00

2.0

3.6

39.7

71.1

ug/g

2.78

312

(3042936) Bacteria identified in Isolate by Culture

166

1.03

0.00

5.6

1.9

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

117

1.03

0.00

2.0

2.1

—

14.6

—

(43534046) Estradiol (E2) [Moles/volume] in Serum or Plasma by High sensitivity method

1.00

0.00

2.0

2.3

0.2

0.1

nmol/l

—

(3045414) Leukocytes [Presence] in Urine

1.00

0.00

4.4

1.7

—

(3016228) CD19 cells/100 cells in Blood

0.00

0.0

4.0

—

13.6

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.4

—

33.2

—

(40760512) CD34 cells/100 cells in Bone marrow

0.00

0.0

2.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.4

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.91

0.00

1.2

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.95

0.00

1.4

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

3.5

—

0.3

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

1.02

0.00

7.8

6.3

1.4

2.1

ug/l

—

(36305075) Vedolizumab [Mass/volume] in Serum or Plasma by Immunoassay

0.00

0.0

26.5

—

25.8

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.93

0.00

3.2

3.8

—

87.4

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

25.8

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.4

—

107.0

—

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

0.00

0.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(40757373) Influenza virus identified in Isolate

0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

9.9

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

0.0

2.2

—

1.3

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(4211845)

0.00

0.0

1.0

—

(3017461) Flecainide [Moles/volume] in Serum or Plasma

0.00

0.0

5.1

—

0.5

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

761.6

—

(3032641) Amino acids panel - Urine

0.00

0.0

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.96

0.00

1.0

1.2

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3008860) Bordetella pertussis IgM Ab [Presence] in Serum

0.00

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.86

0.00

1.3

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(40760435) Tropomyosin IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(37020300) Entamoeba histolytica DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.91

0.00

1.1

—

(3020229) Cytomegalovirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.6

—

(40757578) FLT3 gene targeted mutation analysis in Bone marrow by Molecular genetics method

0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3038702) Sodium [Moles/volume] in Capillary blood

0.00

0.0

5.6

—

138.7

—

(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)

0.00

0.0

1.5

—

1.6

—

(21494814) CD8 cells/100 lymphocytes in Specimen

0.00

0.0

4.0

—

(3004280) Aldosterone [Moles/volume] in Serum or Plasma --supine

0.00

0.0

1.0

—

305.0

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(1175553) Vedolizumab and Vedolizumab Ab panel [Mass/volume] - Serum or Plasma

0.00

0.0

26.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

11.4

—

47.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.96

0.00

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.02

0.00

1.2

1.4

—

(40758990) Choriogonadotropin.beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_BACTERIAL_SEPSIS_NEWBO and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
P16_BACTERIAL_SEPSIS_NEWBO	1.309 [1.03, 1.66]	0.027
Birth year	0.988 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 15045 males with P16_BACTERIAL_SEPSIS_NEWBO died.

Mortality risk

Mortality risk for people of age

years, who have P16_BACTERIAL_SEPSIS_NEWBO.

N-year risk	Females	Males
1	No data	0.274%
5	No data	1.604%
10	No data	3.955%
15	No data	7.652%
20	No data	12.738%

Relationships between endpoints

↥

Index endpoint: P16_BACTERIAL_SEPSIS_NEWBO – Bacterial sepsis of newborn

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Bacterial sepsis of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints