Infections specific to the perinatal period

P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P35-P39
  • Cause of death: ICD-10 P35-P39

2 out of 7 registries used, show all original rules.

438

4. Check minimum number of events

None

438

5. Include endpoints

438

6. Filter based on genotype QC (FinnGen only)

417

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Infectiones temporis perinatalis specificae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42413 17614 24798
Only index persons 19844 8095 11749
Unadjusted period prevalence (%)
Whole population 0.61 0.50 0.69
Only index persons 0.39 0.30 0.45
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 417 236 181
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
437
Matched controls
4368
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
+∞
177.5
158
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
+∞
165.4
148
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
5.0
30.0
72
166
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
7.5
28.5
43
63
P39.1
ICD-10 Finland
Neonatal conjunctivitis and dacryocystitis
+∞
26.3
25
*
P36.0
ICD-10 Finland
Sepsis of newborn due to streptococcus, group B
+∞
24.2
23
*
P36.99
ICD-10 Finland
Bacterial sepsis of newborn, unspecified
+∞
22.1
21
*
P07.3
ICD-10 Finland
Other preterm infants
4.2
21.4
62
165
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
18.4
20.3
31
18
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
11.5
13.2
24
22
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
12.6
12
*
P39.4
ICD-10 Finland
Neonatal skin infection
+∞
11.5
11
*
P39.0
ICD-10 Finland
Neonatal infective mastitis
+∞
10.5
10
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.0
8.2
36
125
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
6.3
7.9
20
33
WX722
NOMESCO Finland
PEEP
3.9
7.9
23
61
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
45.8
7.7
9
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
3.8
7.6
23
63
ZX198
NOMESCO Finland
Other local administration
11.1
7.3
13
12
602
Kela drug reimbursment
Children's severe malnutrition
2.8
6.6
33
124
P38
ICD-10 Finland
Omphalitis of newborn with or without mild haemorrhage
70.8
6.4
7
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
3.1
6.3
26
87
P35.1
ICD-10 Finland
Congenital cytomegalovirus infection
+∞
6.3
6
*
P36.4
ICD-10 Finland
Sepsis of newborn due to Escherichia coli
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
507
1.76
4.72
5.0
4.2
—
—
—
0
0
18
65
2.84
3.90
3.4
4.4
32.28
22.27
umol/l
1.06
18
65
26
129
2.08
2.92
10.3
11.9
0.67
0.63
%
0.23
26
129
8
20
4.05
2.58
1.1
1.2
—
—
—
0
0
32
185
1.79
2.35
5.0
5.9
0.17
0.00
%
0.78
12
59
6
13
4.66
2.27
1.0
1.1
—
—
—
0
0
5
9
5.60
2.22
1.0
1.0
—
—
—
0
0
14
61
2.34
2.16
3.5
8.0
—
—
—
0
0
7
19
3.72
2.16
1.0
1.1
—
—
—
0
0
9
31
2.94
2.08
1.2
3.5
—
—
—
0
0
33
201
1.69
2.05
5.2
5.8
0.92
0.54
%
0.38
12
80
6
15
4.04
2.04
1.2
1.2
17.65
18.38
umol/l
—
6
15
362
3377
1.42
2.02
12.3
10.3
22.72
22.71
mg/l
0.00
246
2249
83
628
1.40
1.93
3.4
3.7
4.11
3.59
e6/l
0.11
42
354
0
51
0.00
1.90
0.0
1.0
—
—
—
0
0
30
183
1.69
1.87
5.4
5.2
0.73
0.36
%
0.47
11
70
17
87
1.99
1.82
19.7
13.8
—
—
—
0
0
8
29
2.79
1.80
1.0
1.1
—
—
—
0
0
6
19
3.19
1.66
1.0
1.0
—
—
—
0
0
55
399
1.43
1.63
1.7
1.4
17.12
18.68
nmol/l
0.51
46
350
10
42
2.41
1.62
1.2
1.0
—
—
—
0
0
10
42
2.41
1.62
1.1
1.0
—
—
—
0
0
5
14
3.60
1.62
2.2
22.8
—
—
—
0
0
156
1328
1.27
1.59
3.5
3.3
0.00
0.00
estimate
-0.00
29
233
6
20
3.03
1.58
2.2
1.6
32.33
31.50
pg
—
6
20
170
1464
1.26
1.57
13.5
11.8
1.23
1.23
mmol/l
0.08
162
1397
30
193
1.59
1.55
5.4
5.8
0.00
0.04
%
—
10
71
82
642
1.34
1.55
4.7
4.2
7.39
7.39
ph
—
10
115
42
292
1.48
1.55
2.1
2.4
6.61
5.48
u/l
0.66
30
189
155
1324
1.26
1.53
5.3
4.8
0.00
0.00
estimate
-0.00
29
240
36
245
1.51
1.48
1.6
1.4
—
—
—
0
0
81
638
1.33
1.47
3.1
3.5
0.00
0.00
estimate
-0.00
30
231
28
180
1.59
1.46
1.6
1.5
—
—
—
0
0
19
110
1.76
1.45
1.3
4.1
64.08
63.74
g/l
0.06
19
102
176
1534
1.25
1.44
12.7
11.1
1.23
1.22
mmol/l
0.42
162
1405
5
16
3.15
1.44
2.2
1.2
—
—
—
0
0
32
214
1.53
1.42
1.0
1.1
—
—
—
0
0
155
1334
1.25
1.42
3.6
3.4
0.00
0.00
estimate
-0.00
30
235
15
81
1.88
1.41
15.9
15.9
72.40
70.50
%
0.18
15
81
120
1003
1.27
1.40
4.2
4.2
0.25
0.19
e6/l
0.19
84
762
214
1911
1.23
1.39
9.3
10.6
0.00
0.01
e9/l
0.48
166
1451
125
1052
1.26
1.38
7.1
7.7
19.26
19.97
umol/l
0.07
112
956
318
2974
1.25
1.30
15.4
11.6
3.91
3.91
mmol/l
0.06
311
2863
134
1145
1.24
1.29
3.4
3.1
6.44
6.15
ph
0.62
18
125
84
681
1.29
1.25
8.7
10.7
—
—
—
0
0
6
25
2.42
1.24
1.2
1.2
0.42
0.42
nmol/l
—
6
25
6
25
2.42
1.24
1.5
3.0
1.01
1.10
umol/l
—
6
25
91
746
1.28
1.24
3.3
3.2
—
—
—
0
0
125
1066
1.24
1.22
4.5
4.3
24.82
22.77
e6/l
0.07
89
819
106
891
1.25
1.18
3.0
3.3
2.61
2.70
mg/l
0.20
95
796
0
34
0.00
1.16
0.0
1.2
—
33.41
—
0
9
0
34
0.00
1.16
0.0
1.2
—
18.50
—
0
10
119
1015
1.24
1.16
4.2
4.2
—
—
—
0
0
32
225
1.45
1.16
2.7
3.6
—
—
—
0
0
8
39
2.07
1.15
6.6
8.5
—
—
—
0
0
92
764
1.26
1.13
3.7
2.7
2.39
2.40
mmol/l
0.33
81
704
21
136
1.57
1.10
3.4
3.9
—
—
—
0
0
12
66
1.84
1.10
1.8
1.6
4.03
4.96
iu/l
—
6
23
199
1795
1.20
1.09
6.9
5.4
124.97
120.05
u/l
0.34
183
1681
5
21
2.40
1.09
1.2
1.4
—
—
—
0
0
76
620
1.27
1.09
9.1
9.0
—
—
—
0
0
6
121
0.49
1.07
1.2
1.1
—
7.07
—
0
20
7
33
2.14
1.06
2.0
2.0
—
—
—
0
0
316
2980
1.22
1.05
15.4
11.6
139.43
139.47
mmol/l
0.15
309
2888
37
273
1.39
1.05
1.6
2.1
—
—
—
0
0
79
651
1.26
1.04
2.8
2.9
1.02
1.02
kg/l
1.58
18
106
5
22
2.29
1.03
1.2
1.2
—
—
—
0
0
5
110
0.45
1.01
2.8
2.6
—
—
—
0
0
62
500
1.28
0.98
1.8
1.7
—
—
—
0
0
60
482
1.28
0.98
1.9
1.6
—
—
—
0
0
40
303
1.35
0.98
1.3
1.3
306.77
136.52
iu/ml
—
8
93
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
79
658
1.24
0.96
3.0
2.9
—
—
—
0
0
34
253
1.37
0.93
2.2
2.0
207.75
168.88
u/ml
0.31
16
110
342
3268
1.21
0.90
17.8
14.3
13.69
13.26
%
1.51
335
3200
34
255
1.36
0.89
1.6
1.4
536.67
29515850.73
pmol/l
0.50
27
227
16
103
1.57
0.88
4.8
5.2
—
—
—
0
0
10
56
1.80
0.88
2.2
2.4
—
—
—
0
0
10
56
1.80
0.88
1.1
1.2
—
—
—
0
0
60
490
1.26
0.87
4.1
4.9
5.23
1.34
mg/l
0.52
39
340
23
162
1.44
0.86
1.5
1.6
—
—
—
0
0
324
3086
1.19
0.86
8.9
8.3
26.01
24.19
u/l
0.76
310
2975
23
163
1.43
0.83
1.8
1.7
—
—
—
0
0
141
1261
1.17
0.82
5.4
5.0
46.02
55.56
e6/l
0.16
91
852
139
1544
0.85
0.81
1.7
1.8
0.82
3.20
u/ml
2.79
23
288
8
47
1.71
0.81
6.0
8.8
2.67
2.38
mg/l
—
8
37
0
24
0.00
0.79
0.0
3.7
—
230.29
—
0
14
0
24
0.00
0.79
0.0
2.5
—
—
—
0
0
87
749
1.20
0.78
9.7
9.4
0.13
1.19
mmol/l
1.21
70
585
398
3878
1.29
0.78
18.2
14.8
86.21
86.07
fl
0.21
392
3798
16
107
1.51
0.77
4.7
4.9
3.54
3.28
mmol/l
0.59
16
102
16
107
1.51
0.77
2.4
1.6
—
—
—
0
0
350
3368
1.19
0.76
9.5
7.6
—
—
—
0
0
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
398
3880
1.28
0.75
18.2
14.8
28.86
28.91
pg
0.20
392
3803
398
3881
1.28
0.74
18.2
14.8
4.61
4.64
e12/l
0.50
374
3679
129
1155
1.17
0.74
6.7
9.3
—
—
—
0
0
193
1781
1.15
0.73
3.1
2.7
2.62
2.60
mmol/l
0.10
185
1668
5
25
2.01
0.73
1.0
1.1
—
—
—
0
0
7
39
1.81
0.72
1.3
1.7
—
—
—
0
0
398
3884
1.27
0.71
18.2
14.9
6.77
6.72
e9/l
0.16
375
3688
9
57
1.59
0.71
1.3
1.4
—
—
—
0
0
398
3885
1.27
0.70
18.5
15.1
132.57
133.54
g/l
0.70
392
3813
9
146
0.61
0.70
1.2
1.1
—
—
—
0
0
24
178
1.37
0.70
2.7
2.2
—
—
—
0
0
7
41
1.72
0.70
6.6
8.8
—
—
—
0
0
397
3875
1.26
0.69
18.3
14.9
274.86
270.44
e9/l
0.59
372
3689
5
27
1.86
0.68
1.0
1.5
—
—
—
0
0
397
3877
1.26
0.67
18.9
15.4
39.52
39.75
%
0.46
381
3689
80
694
1.19
0.67
9.4
9.1
22.84
23.62
mmol/l
1.56
80
694
57
673
0.82
0.67
1.6
1.7
—
—
—
0
0
13
86
1.53
0.66
5.7
6.0
—
—
—
0
0
78
676
1.19
0.66
1.8
1.5
97.98
99.13
pmol/l
0.06
48
358
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
7
44
1.60
0.65
2.6
2.5
—
—
—
0
0
205
1913
1.13
0.64
9.1
9.4
—
—
—
0
0
232
2183
1.13
0.63
10.0
10.5
3.27
3.44
e9/l
0.64
192
1826
24
182
1.34
0.62
1.7
1.6
1091.06
1126.66
nmol/l
0.06
18
137
36
290
1.26
0.61
11.8
9.7
105.06
105.39
mmol/l
0.19
36
290
60
512
1.20
0.61
1.9
1.7
1.60
1.18
mmol/l
0.51
55
474
182
1692
1.13
0.59
3.0
2.6
1.16
1.07
mmol/l
0.87
174
1596
6
36
1.67
0.57
2.2
1.9
—
—
—
0
0
11
73
1.52
0.56
1.2
2.3
—
—
—
0
0
215
2024
1.12
0.56
8.0
8.8
49.28
49.68
%
0.17
210
1936
8
55
1.46
0.56
1.4
1.4
—
—
—
0
0
8
55
1.46
0.56
7.1
2.6
—
—
—
0
0
8
55
1.46
0.56
1.4
1.4
—
—
—
0
0
10
65
1.55
0.56
1.6
1.6
—
—
—
0
0
6
37
1.63
0.55
1.3
1.3
—
—
—
0
0
39
323
1.23
0.54
5.2
5.0
62.05
62.41
e9/l
0.02
28
203
39
324
1.22
0.53
1.3
2.1
—
—
—
0
0
11
75
1.48
0.51
2.9
4.9
—
—
—
0
0
16
118
1.37
0.50
1.1
1.4
0.70
3.40
u/ml
1.40
11
77
43
363
1.20
0.50
4.9
3.2
1166.32
1394.04
ng/l
0.11
19
204
33
271
1.23
0.50
2.0
2.4
4.49
7.73
iu/l
2.85
24
182
33
271
1.23
0.50
5.1
4.2
5.74
9.38
mg/mmol
0.44
27
219
7
107
0.65
0.49
1.0
1.2
—
—
—
0
0
169
1580
1.11
0.49
4.2
3.2
36.85
36.35
mmol/mol
0.20
160
1481
33
272
1.23
0.49
4.0
3.8
55.50
92.90
mg/l
0.55
27
219
8
119
0.67
0.46
1.3
1.2
—
—
—
0
0
192
1812
1.11
0.46
3.2
2.8
4.29
4.30
mmol/l
0.03
185
1724
218
2071
1.10
0.46
8.3
8.9
35.56
34.90
%
0.34
213
1981
80
718
1.14
0.46
5.8
5.5
1.14
1.11
inr
0.14
26
206
78
699
1.14
0.45
3.1
3.4
509.97
609.95
mosm/kgh2o
2.80
68
611
73
652
1.14
0.45
2.0
1.6
—
—
—
0
0
6
95
0.63
0.42
1.0
1.0
—
—
—
0
0
6
95
0.63
0.42
1.0
1.0
18.50
19.17
mmol/l
—
6
95
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.6
—
3.78
—
0
15
0
15
0.00
0.41
0.0
4.7
—
4.56
—
0
15
0
16
0.00
0.41
0.0
1.1
—
1164.31
—
0
16
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
6.4
—
44.28
—
0
16
11
79
1.40
0.41
3.2
4.3
90.00
5.09
u/ml
0.48
11
79
214
2040
1.10
0.41
8.0
9.0
0.56
0.55
e9/l
0.11
180
1705
223
2130
1.09
0.41
4.3
4.4
8.97
6.91
mm/h
1.27
209
1981
31
260
1.21
0.40
2.9
1.8
2.43
2.41
mmol/l
0.27
25
214
0
18
0.00
0.40
0.0
1.2
—
208.91
—
0
18
86
784
1.12
0.39
14.7
12.9
24.64
24.73
mmol/l
0.12
86
784
186
1765
1.09
0.39
3.1
2.7
1.36
1.41
mmol/l
0.86
178
1664
11
80
1.38
0.38
1.5
2.0
—
—
—
0
0
5
36
1.39
0.38
1.8
1.3
—
—
—
0
0
207
1975
1.09
0.38
8.5
9.1
2.91
3.23
%
1.02
202
1879
62
555
1.14
0.38
2.3
1.8
—
—
—
0
0
13
98
1.34
0.37
2.3
4.4
26.00
26.14
%
0.02
13
98
16
125
1.29
0.37
11.5
13.9
92.99
95.69
%
0.37
16
125
5
37
1.35
0.37
3.8
2.1
—
—
—
0
0
219
2098
1.09
0.36
7.9
8.9
2.29
2.27
e9/l
0.08
190
1809
13
99
1.32
0.35
1.2
1.2
199.83
314.36
iu/ml
—
6
28
202
1930
1.09
0.35
4.6
4.0
—
—
—
0
0
16
126
1.28
0.35
13.7
9.0
22.38
23.18
mmol/l
0.61
16
121
208
1991
1.08
0.35
8.9
9.2
8.41
8.28
%
0.33
203
1892
213
2041
1.08
0.35
8.1
9.0
0.04
0.04
e9/l
0.96
179
1705
44
388
1.15
0.34
2.7
2.5
—
—
—
0
0
14
109
1.29
0.34
12.4
12.5
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
159
1509
1.08
0.32
3.6
4.3
27.77
26.33
u/l
0.22
146
1449
41
361
1.15
0.32
2.7
2.3
16801.80
7894.14
u/l
—
6
108
15
119
1.27
0.32
1.9
4.7
—
—
—
0
0
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
50
449
1.13
0.30
1.2
1.7
—
—
—
0
0
7
54
1.30
0.30
32.1
19.6
11.73
11.66
%
—
7
54
10
75
1.34
0.30
2.4
5.6
—
—
—
0
0
14
111
1.27
0.30
2.4
4.6
16.86
17.68
%
0.08
14
111
22
185
1.20
0.29
1.2
1.3
—
—
—
0
0
95
1016
0.92
0.29
1.8
1.5
—
—
—
0
0
7
56
1.25
0.29
5.9
4.5
—
—
—
0
0
35
396
0.87
0.29
1.1
1.2
—
3.30
—
0
5
40
448
0.88
0.28
1.6
1.6
592.00
524.44
titre
—
5
72
176
1686
1.07
0.28
3.9
3.3
57.74
46.98
ug/l
0.38
167
1596
49
443
1.12
0.27
2.2
2.7
374.05
350.88
nmol/l
0.34
44
424
11
139
0.79
0.27
3.0
2.1
—
—
—
0
0
13
104
1.26
0.26
2.3
4.4
67.62
68.02
%
0.04
13
104
13
104
1.26
0.26
2.3
4.4
10.23
8.09
%
0.71
13
104
30
263
1.15
0.26
1.7
1.4
—
—
—
0
0
80
745
1.09
0.26
3.1
2.3
—
—
—
0
0
59
641
0.91
0.26
1.3
1.2
—
—
—
0
0
111
1050
1.08
0.25
1.8
1.8
—
—
—
0
0
199
1921
1.07
0.25
2.5
2.2
5.57
5.33
mmol/l
0.84
177
1743
5
39
1.28
0.23
10.8
2.9
1.07
1.26
mmol/l
—
5
32
5
39
1.28
0.23
1.0
1.9
—
—
—
0
0
7
94
0.74
0.22
1.6
1.4
—
—
—
0
0
216
2096
1.06
0.22
9.0
9.6
0.19
0.21
e9/l
1.08
186
1796
172
1659
1.06
0.22
9.5
6.5
6.29
6.04
mmol/l
0.56
164
1549
5
42
1.19
0.21
4.2
3.0
62.20
56.50
umol/l
—
5
42
0
10
0.00
0.21
0.0
2.2
—
171.30
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
0.28
—
0
10
0
11
0.00
0.21
0.0
1.4
—
10311.83
—
0
6
8
102
0.78
0.21
1.3
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
5
43
1.16
0.21
3.6
2.8
35.00
52.83
u/ml
—
5
35
16
187
0.85
0.20
1.2
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
106.57
—
0
14
15
127
1.19
0.19
11.9
13.7
0.69
0.74
%
0.27
15
127
6
51
1.18
0.19
6.7
4.8
—
—
—
0
0
41
376
1.10
0.19
7.0
7.2
4.78
6.54
umol/l
0.95
35
313
29
261
1.12
0.18
3.5
2.4
27.58
30.80
u/l
0.43
24
212
7
58
1.21
0.18
3.4
8.0
7.96
9.16
kpa
—
7
58
7
58
1.21
0.18
3.3
8.0
5.70
4.85
kpa
—
7
58
19
167
1.14
0.17
1.5
1.3
—
—
—
0
0
8
70
1.14
0.16
1.0
1.1
—
—
—
0
0
52
487
1.08
0.16
1.3
1.7
—
—
—
0
0
6
76
0.79
0.15
3.8
1.9
—
—
—
0
0
9
78
1.16
0.15
1.3
1.4
—
—
—
0
0
9
80
1.13
0.15
1.1
1.7
0.74
4.76
u/ml
—
9
80
9
81
1.11
0.15
1.0
1.2
—
—
—
0
0
13
150
0.86
0.15
7.8
5.8
125.85
176.99
ng/l
0.41
13
141
9
82
1.10
0.15
4.1
4.4
43.78
50.89
%
—
9
82
22
198
1.12
0.14
1.2
1.1
10.90
6.31
u/ml
0.46
16
126
75
785
0.95
0.14
4.0
3.4
—
—
—
0
0
257
2525
1.04
0.14
3.9
3.2
14.32
14.36
pmol/l
0.10
232
2253
8
99
0.80
0.13
3.1
1.6
—
—
—
0
0
47
442
1.07
0.13
3.5
2.4
24.29
25.99
ng/l
0.05
14
155
17
151
1.13
0.13
1.3
1.4
0.22
0.20
g/l
0.43
17
145
9
110
0.81
0.13
5.4
3.5
—
—
—
0
0
29
313
0.92
0.12
4.2
1.9
—
—
—
0
0
17
152
1.12
0.12
1.2
1.4
1.18
1.15
g/l
0.26
17
145
18
162
1.12
0.12
1.1
1.1
—
—
—
0
0
75
720
1.05
0.12
3.9
3.4
7.58
7.36
e6/l
0.05
67
644
51
484
1.06
0.11
1.3
1.7
—
—
—
0
0
139
1425
0.96
0.11
1.6
1.7
1.48
1.54
g/l
0.25
74
725
135
1317
1.04
0.10
2.4
2.1
—
—
—
0
0
26
241
1.08
0.10
1.7
2.2
11.59
8.26
nmol/l
0.49
21
209
280
2832
0.97
0.10
4.3
3.6
2.01
1.99
mu/l
0.11
260
2655
12
135
0.89
0.10
1.1
1.2
—
—
—
0
0
51
487
1.05
0.10
1.3
1.7
—
—
—
0
0
5
45
1.11
0.10
1.0
1.8
7.57
7.71
u/ml
—
5
34
56
581
0.96
0.08
2.2
1.8
—
—
—
0
0
5
65
0.77
0.08
1.0
1.4
—
184.00
—
0
15
7
65
1.08
0.08
5.6
4.4
—
—
—
0
0
7
65
1.08
0.08
3.4
7.3
7.38
7.39
ph
—
7
59
8
78
1.03
0.07
4.6
7.8
—
—
—
0
0
43
446
0.96
0.06
2.5
1.7
—
—
—
0
0
76
741
1.03
0.06
2.4
3.3
79.36
113.07
ug/g
0.80
60
578
16
172
0.93
0.06
1.2
1.1
1.06
0.65
u/ml
—
8
77
30
314
0.95
0.06
1.3
1.2
2.30
2.61
u/ml
0.11
24
230
50
484
1.04
0.05
1.3
1.7
—
—
—
0
0
16
149
1.08
0.05
1.6
1.8
—
—
—
0
0
34
328
1.04
0.04
1.2
1.2
8.17
7.15
u/ml
0.11
25
245
19
181
1.05
0.03
1.2
1.1
26.50
10.07
u/ml
0.37
12
108
11
102
1.08
0.03
2.5
4.4
41.49
36.66
%
0.84
11
102
39
381
1.03
0.02
1.3
1.7
—
—
—
0
0
10
93
1.08
0.02
1.6
1.7
—
—
—
0
0
54
531
1.02
0.02
8.5
6.1
32.61
30.97
s
0.88
54
524
33
322
1.03
0.01
1.2
1.2
0.45
1.06
u/ml
1.28
24
230
97
963
1.01
0.00
2.4
2.1
—
—
—
0
0
34
346
0.98
0.00
1.2
1.2
2.11
10.23
u/ml
—
10
103
38
374
1.02
0.00
1.2
1.2
8.83
14.84
iu/ml
—
6
83
12
115
1.04
0.00
1.0
1.1
—
—
—
0
0
25
252
0.99
0.00
1.5
1.5
—
—
—
0
0
11
105
1.05
0.00
3.8
2.1
—
—
—
0
0
23
228
1.01
0.00
1.2
2.0
—
—
—
0
0
18
184
0.98
0.00
1.0
1.0
—
—
—
0
0
22
219
1.00
0.00
1.3
1.4
—
—
—
0
0
35
348
1.01
0.00
1.3
1.3
3.30
3.61
u/ml
0.06
25
244
12
116
1.03
0.00
1.0
1.1
—
—
—
0
0
8
80
1.00
0.00
1.3
1.8
211.50
139.65
ng/l
—
8
75
0
9
0.00
-0.00
0.0
1.4
—
61.33
—
0
9
8
81
0.99
-0.00
4.1
4.0
2.61
3.28
e9/l
—
8
81
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.6
—
—
—
0
0
7
76
0.92
-0.00
1.0
1.3
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
79
1.01
-0.00
2.0
3.6
724.38
782.81
e6/l
—
8
79
0
6
0.00
-0.00
0.0
3.5
—
13.17
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
305.00
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.60
—
0
6
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0
7
74
0.94
-0.00
7.4
5.9
2.01
2.05
ug/l
—
7
74
7
72
0.97
-0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
75.10
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.1
—
138.33
—
0
9
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
22.0
—
13.62
—
0
6
8
85
0.94
-0.00
1.6
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
95.98
—
0
8
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
1737.50
—
0
8
8
86
0.93
-0.00
9.1
3.1
611.25
335.88
ug/l
—
8
76
0
7
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_INFECTIONS_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.84 [1.45, 2.34] < 0.001
Birth year 0.998 [0.99, 1.01] 0.613

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 16734 females with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.099 [0.9, 1.34] 0.351
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 23642 males with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_INFECTIONS_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.158% 0.199%
5 1.081% 1.32%
10 2.695% 3.159%
15 5.399% 6.062%
20 9.582% 10.507%

Relationships between endpoints

Index endpoint: P16_INFECTIONS_SPECIFIC_PERINA_PERIOD – Infections specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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