Infections specific to the perinatal period

P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P35-P39
  • Cause of death: ICD-10 P35-P39

2 out of 7 registries used, show all original rules.

436

4. Check minimum number of events

None

436

5. Include endpoints

436

6. Filter based on genotype QC (FinnGen only)

436

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Infectiones temporis perinatalis specificae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42413 17614 24798
Only index persons 19844 8095 11749
Unadjusted period prevalence (%)
Whole population 0.61 0.50 0.69
Only index persons 0.39 0.30 0.45
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 436 246 190
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
383
Matched controls
3828
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
+∞
157.5
140
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
+∞
144.1
129
*
P39.1
ICD-10 Finland
Neonatal conjunctivitis and dacryocystitis
+∞
23.2
22
*
P36.0
ICD-10 Finland
Sepsis of newborn due to streptococcus, group B
+∞
21.0
20
*
P36.99
ICD-10 Finland
Bacterial sepsis of newborn, unspecified
+∞
20.0
19
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
5.1
19.0
63
142
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
21.3
18.0
26
13
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
7.6
15.0
35
50
P07.3
ICD-10 Finland
Other preterm infants
4.5
14.5
53
132
P39.4
ICD-10 Finland
Neonatal skin infection
+∞
11.5
11
*
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
10.5
10
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
9.5
10.1
20
22
P39.0
ICD-10 Finland
Neonatal infective mastitis
+∞
9.4
9
*
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
+∞
9.4
9
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
6.0
7.0
18
31
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
7.6
6.5
14
19
P38
ICD-10 Finland
Omphalitis of newborn with or without mild haemorrhage
71.0
6.4
7
*
ZX198
NOMESCO Finland
Other local administration
9.5
6.3
12
13
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
4.7
6.1
19
42

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
504
1.72
4.30
5.0
4.2
—
—
—
0
0
18
65
2.84
3.90
3.4
4.4
32.3
22.3
umol/l
1.06
18
65
8
20
4.05
2.58
1.1
1.2
—
—
—
0
0
6
13
4.66
2.27
1.0
1.1
—
—
—
0
0
14
60
2.38
2.24
3.5
7.8
—
—
—
0
0
5
9
5.60
2.22
1.0
1.0
—
—
—
0
0
7
19
3.72
2.16
1.0
1.1
—
—
—
0
0
31
184
1.74
2.10
5.2
5.9
0.0
0.0
%
—
10
52
6
15
4.04
2.04
1.2
1.2
17.6
18.4
umol/l
—
6
15
360
3362
1.41
1.96
12.1
10.3
22.6
22.7
mg/l
0.01
244
2237
0
51
0.00
1.90
0.0
1.0
—
—
—
0
0
17
86
2.02
1.87
19.8
14.0
—
—
—
0
0
32
199
1.66
1.86
5.4
5.8
0.6
0.5
%
—
10
66
8
29
2.79
1.80
1.0
1.1
—
—
—
0
0
8
30
2.70
1.73
1.3
2.4
—
—
—
0
0
10
42
2.41
1.68
1.2
1.0
—
—
—
0
0
10
42
2.41
1.68
1.1
1.0
—
—
—
0
0
6
19
3.19
1.66
1.0
1.0
—
—
—
0
0
29
182
1.64
1.65
5.6
5.2
0.7
0.4
%
—
9
46
5
14
3.60
1.62
2.2
22.8
—
—
—
0
0
54
392
1.43
1.60
1.7
1.4
17.1
18.7
nmol/l
0.51
45
343
6
20
3.03
1.58
2.2
1.6
32.3
31.5
pg
—
6
20
42
291
1.49
1.57
2.1
2.4
6.6
5.4
u/l
0.69
30
188
169
1456
1.26
1.55
13.5
11.8
1.2
1.2
mmol/l
0.06
161
1387
28
179
1.60
1.49
1.6
1.5
—
—
—
0
0
81
637
1.33
1.49
4.7
4.1
7.4
7.4
ph
—
10
114
81
637
1.33
1.49
3.1
3.5
0.0
0.0
estimate
0.00
30
231
15
80
1.91
1.46
15.9
16.1
72.4
70.8
%
0.15
15
80
154
1322
1.25
1.44
3.4
3.3
0.0
0.0
estimate
0.00
27
228
35
240
1.50
1.39
1.6
1.4
—
—
—
0
0
153
1317
1.25
1.39
5.1
4.8
0.0
0.0
estimate
0.00
29
240
6
23
2.63
1.37
1.2
1.2
0.4
0.4
nmol/l
—
6
23
29
192
1.55
1.35
5.5
5.9
0.0
0.0
%
—
10
61
174
1524
1.24
1.35
12.7
11.1
1.2
1.2
mmol/l
0.49
160
1393
153
1326
1.24
1.30
3.5
3.4
0.0
0.0
estimate
0.00
30
235
316
2955
1.25
1.29
15.2
11.6
3.9
3.9
mmol/l
0.07
309
2845
212
1902
1.22
1.29
9.2
10.6
0.0
0.0
e9/l
0.48
164
1444
123
1042
1.25
1.28
7.2
7.7
19.5
20.0
umol/l
0.05
110
946
118
997
1.25
1.25
4.2
4.2
0.3
0.2
e6/l
0.20
82
754
6
25
2.42
1.24
1.5
3.0
1.0
1.1
umol/l
—
6
25
18
108
1.69
1.24
1.3
3.7
63.7
63.7
g/l
0.01
18
100
31
214
1.48
1.22
1.0
1.1
—
—
—
0
0
90
741
1.27
1.19
3.3
3.2
—
—
—
0
0
21
134
1.60
1.16
3.6
3.9
—
—
—
0
0
0
34
0.00
1.16
0.0
1.2
—
33.4
—
0
9
0
34
0.00
1.16
0.0
1.2
—
18.5
—
0
10
83
679
1.27
1.16
8.6
10.7
—
—
—
0
0
32
225
1.46
1.16
2.7
3.6
—
—
—
0
0
8
39
2.07
1.15
6.6
8.5
—
—
—
0
0
16
95
1.71
1.15
2.6
2.2
—
—
—
0
0
16
95
1.71
1.15
2.6
2.2
—
—
—
0
0
16
95
1.71
1.15
2.6
2.2
—
—
—
0
0
16
95
1.71
1.15
2.6
2.2
—
—
—
0
0
91
757
1.25
1.11
3.7
2.6
2.4
2.4
mmol/l
0.40
79
694
76
619
1.28
1.10
9.1
9.0
—
—
—
0
0
173
1540
1.20
1.10
8.3
9.2
—
—
—
0
0
12
66
1.84
1.10
1.8
1.6
4.0
5.0
iu/l
—
6
23
123
1059
1.22
1.10
4.4
4.4
25.2
22.1
e6/l
0.11
87
813
5
21
2.40
1.09
1.2
1.4
—
—
—
0
0
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
124
1069
1.22
1.09
3.4
3.1
—
—
—
0
0
6
121
0.49
1.07
1.2
1.1
—
7.1
—
0
20
7
33
2.14
1.06
2.0
2.0
—
—
—
0
0
197
1780
1.19
1.05
6.9
5.4
125.6
120.6
u/l
0.34
181
1664
37
273
1.39
1.05
1.6
2.1
—
—
—
0
0
314
2961
1.22
1.04
15.2
11.6
139.4
139.5
mmol/l
0.18
307
2870
104
885
1.23
1.03
3.0
3.4
2.6
2.7
mg/l
0.27
94
790
117
1009
1.22
1.02
4.2
4.2
—
—
—
0
0
62
499
1.28
0.99
1.8
1.7
—
—
—
0
0
34
250
1.39
0.99
2.2
2.0
207.8
169.4
u/ml
0.31
16
110
40
303
1.35
0.98
1.3
1.3
306.8
136.5
iu/ml
—
8
93
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
78
649
1.25
0.96
2.8
2.9
1.0
1.0
kg/l
1.99
17
106
16
102
1.59
0.91
4.8
5.2
—
—
—
0
0
59
478
1.27
0.91
1.9
1.6
—
—
—
0
0
6
29
2.08
0.89
2.0
2.2
—
—
—
0
0
10
56
1.80
0.88
1.1
1.2
—
—
—
0
0
10
56
1.80
0.88
2.2
2.4
—
—
—
0
0
78
657
1.23
0.86
2.9
2.9
—
—
—
0
0
138
1538
0.85
0.85
1.7
1.8
0.8
3.2
u/ml
2.80
23
287
23
163
1.43
0.83
1.8
1.7
—
—
—
0
0
59
484
1.25
0.83
4.1
4.9
5.4
1.3
mg/l
0.52
38
337
16
105
1.54
0.82
2.4
1.6
—
—
—
0
0
8
47
1.71
0.81
6.0
8.8
2.7
2.4
mg/l
—
8
37
0
24
0.00
0.79
0.0
2.5
—
—
—
0
0
0
24
0.00
0.79
0.0
3.7
—
230.3
—
0
14
16
107
1.51
0.77
4.7
4.9
3.5
3.3
mmol/l
0.59
16
102
396
3859
1.29
0.77
18.0
14.8
86.2
86.0
fl
0.18
390
3781
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
396
3861
1.28
0.74
18.0
14.8
28.9
28.9
pg
0.19
390
3786
139
1252
1.16
0.73
5.4
5.0
45.3
56.0
e6/l
0.18
89
845
396
3862
1.28
0.73
18.0
14.8
4.6
4.6
e12/l
0.46
372
3663
7
39
1.81
0.72
1.3
1.7
—
—
—
0
0
348
3353
1.19
0.72
9.3
7.6
—
—
—
0
0
191
1763
1.15
0.72
3.0
2.7
2.6
2.6
mmol/l
0.21
182
1648
24
177
1.38
0.72
2.7
2.2
—
—
—
0
0
22
160
1.39
0.71
1.5
1.6
—
—
—
0
0
7
40
1.76
0.71
6.6
9.1
—
—
—
0
0
9
57
1.59
0.71
1.3
1.4
—
—
—
0
0
128
1149
1.16
0.71
6.7
9.3
—
—
—
0
0
337
3241
1.17
0.70
17.4
14.3
13.3
13.1
%
1.98
329
3176
9
146
0.61
0.70
1.2
1.1
—
—
—
0
0
396
3866
1.27
0.69
18.3
15.0
132.6
133.5
g/l
0.65
390
3796
396
3866
1.27
0.69
18.0
14.8
6.8
6.7
e9/l
0.12
373
3673
60
505
1.22
0.69
1.9
1.7
1.6
1.2
mmol/l
0.51
55
468
5
27
1.86
0.68
1.0
1.5
—
—
—
0
0
395
3856
1.26
0.68
18.1
14.9
274.8
270.7
e9/l
0.54
370
3673
77
666
1.19
0.67
1.8
1.5
98.9
98.9
pmol/l
0.00
47
352
13
86
1.53
0.66
5.7
6.0
—
—
—
0
0
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
57
671
0.83
0.65
1.6
1.7
—
—
—
0
0
7
44
1.60
0.65
2.6
2.5
—
—
—
0
0
32
252
1.29
0.64
1.6
1.4
567.2
29911146.1
pmol/l
0.50
25
224
85
747
1.17
0.62
9.8
9.4
0.0
1.2
mmol/l
1.40
68
581
10
64
1.57
0.59
1.6
1.6
—
—
—
0
0
180
1674
1.13
0.58
2.9
2.6
1.2
1.1
mmol/l
0.82
172
1580
6
35
1.72
0.58
1.3
1.2
—
—
—
0
0
8
54
1.49
0.57
7.1
2.6
—
—
—
0
0
6
36
1.67
0.57
1.3
1.3
—
—
—
0
0
11
73
1.52
0.56
1.2
2.3
—
—
—
0
0
8
55
1.46
0.56
1.4
1.4
—
—
—
0
0
8
55
1.46
0.56
1.4
1.4
—
—
—
0
0
230
2177
1.12
0.54
10.1
10.4
3.3
3.4
e9/l
0.74
190
1821
39
324
1.22
0.53
1.3
2.1
—
—
—
0
0
23
179
1.30
0.52
1.7
1.7
1124.9
1102.0
nmol/l
0.04
17
134
79
701
1.15
0.52
5.4
5.2
—
—
—
0
0
11
75
1.48
0.51
2.9
4.9
—
—
—
0
0
16
118
1.37
0.50
1.1
1.4
0.8
3.4
u/ml
1.29
11
78
33
271
1.23
0.50
2.0
2.4
4.5
7.7
iu/l
2.85
24
182
7
107
0.65
0.49
1.0
1.2
—
—
—
0
0
213
2017
1.11
0.48
8.0
8.8
49.0
49.6
%
0.28
208
1927
38
320
1.20
0.46
5.3
5.0
62.1
62.0
e9/l
0.00
27
201
8
119
0.67
0.46
1.3
1.2
—
—
—
0
0
167
1565
1.11
0.46
3.9
3.1
36.6
36.3
mmol/mol
0.12
158
1468
190
1794
1.10
0.45
3.1
2.8
4.3
4.3
mmol/l
0.04
182
1705
32
266
1.22
0.44
3.8
3.8
57.3
93.5
mg/l
0.50
26
212
6
95
0.63
0.42
1.0
1.0
18.5
19.2
mmol/l
—
6
95
6
95
0.63
0.42
1.0
1.0
—
—
—
0
0
42
361
1.18
0.42
5.0
3.2
1229.9
1407.8
ng/l
0.08
18
202
0
15
0.00
0.41
0.0
2.6
—
3.8
—
0
15
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
4.7
—
4.6
—
0
15
0
16
0.00
0.41
0.0
6.4
—
44.3
—
0
16
0
16
0.00
0.41
0.0
1.1
—
1164.3
—
0
16
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
10
138
0.72
0.41
3.1
2.1
—
—
—
0
0
72
647
1.13
0.41
2.1
1.6
—
—
—
0
0
34
288
1.20
0.40
12.1
9.7
105.0
105.5
mmol/l
0.30
34
283
7
102
0.68
0.40
1.3
1.2
—
—
—
0
0
216
2063
1.09
0.39
8.3
8.9
35.9
35.0
%
0.56
210
1966
11
80
1.38
0.38
1.5
2.0
—
—
—
0
0
5
36
1.39
0.38
1.8
1.3
—
—
—
0
0
184
1747
1.09
0.38
3.0
2.7
1.4
1.4
mmol/l
0.86
175
1646
13
98
1.34
0.37
2.3
4.4
26.0
26.1
%
0.02
13
98
76
690
1.12
0.37
2.9
3.4
510.4
610.3
mosm/kgh2o
2.69
66
602
5
37
1.35
0.37
3.8
2.1
—
—
—
0
0
221
2117
1.09
0.37
4.3
4.4
8.9
6.9
mm/h
1.19
207
1968
9
70
1.29
0.37
1.0
1.1
—
—
—
0
0
13
99
1.32
0.35
1.2
1.2
199.8
314.4
iu/ml
—
6
28
15
117
1.29
0.35
1.9
4.7
—
—
—
0
0
31
265
1.18
0.34
5.2
4.4
6.0
9.0
mg/mmol
0.33
25
215
30
256
1.18
0.34
3.0
1.8
2.4
2.4
mmol/l
0.28
25
210
212
2033
1.08
0.34
8.1
9.0
0.6
0.6
e9/l
0.11
177
1698
6
45
1.34
0.34
1.2
1.1
—
—
—
0
0
94
1012
0.91
0.33
1.8
1.5
—
—
—
0
0
85
783
1.11
0.33
14.9
12.9
24.7
24.7
mmol/l
0.01
85
783
72
658
1.11
0.32
5.9
4.3
1.1
1.1
inr
0.75
24
197
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
41
362
1.15
0.31
2.7
2.3
16801.8
7894.1
u/l
—
6
108
205
1968
1.08
0.31
8.5
9.1
2.9
3.2
%
0.88
200
1869
7
53
1.33
0.31
32.1
20.0
11.7
11.7
%
—
7
53
49
439
1.13
0.31
2.2
2.7
374.0
351.1
nmol/l
0.34
44
420
7
100
0.69
0.31
3.4
1.6
—
—
—
0
0
50
449
1.13
0.30
1.2
1.7
—
—
—
0
0
217
2090
1.08
0.30
8.0
8.9
2.3
2.3
e9/l
0.16
187
1798
14
111
1.27
0.30
2.4
4.6
16.9
17.7
%
0.08
14
111
200
1921
1.08
0.30
4.6
4.0
—
—
—
0
0
22
185
1.20
0.29
1.2
1.3
—
—
—
0
0
7
56
1.25
0.29
6.3
4.6
—
—
—
0
0
40
448
0.88
0.28
1.6
1.6
592.0
524.4
titre
—
5
72
30
261
1.16
0.28
1.7
1.4
—
—
—
0
0
27
311
0.86
0.28
4.4
1.9
—
—
—
0
0
60
548
1.11
0.28
2.3
1.8
—
—
—
0
0
206
1985
1.07
0.28
8.9
9.2
8.4
8.3
%
0.33
201
1885
356
3499
1.09
0.27
16.4
13.1
39.3
39.4
%
0.26
307
3077
211
2037
1.07
0.27
8.1
9.0
0.0
0.0
e9/l
1.09
177
1702
13
104
1.26
0.26
2.3
4.4
10.2
8.1
%
0.72
13
99
13
104
1.26
0.26
2.3
4.4
67.6
68.0
%
0.04
13
104
15
123
1.23
0.25
12.1
14.0
93.0
95.7
%
0.34
15
123
59
640
0.91
0.25
1.3
1.2
—
—
—
0
0
9
75
1.20
0.25
2.6
5.6
—
—
—
0
0
12
148
0.81
0.25
8.2
5.8
111.8
177.5
ng/l
0.54
12
139
79
737
1.09
0.25
3.0
2.3
—
—
—
0
0
197
1904
1.06
0.23
2.5
2.2
5.5
5.3
mmol/l
0.72
175
1728
5
39
1.28
0.23
10.8
2.6
1.1
1.3
mmol/l
—
5
32
5
39
1.28
0.23
1.0
1.9
—
—
—
0
0
174
1677
1.06
0.23
3.9
3.3
57.7
46.5
ug/l
0.39
165
1587
7
94
0.74
0.22
1.6
1.4
—
—
—
0
0
42
382
1.11
0.22
2.5
2.4
—
—
—
0
0
5
42
1.19
0.21
4.2
3.0
62.2
56.5
umol/l
—
5
42
5
42
1.19
0.21
3.6
2.8
35.0
54.0
u/ml
—
5
34
0
10
0.00
0.21
0.0
2.2
—
171.3
—
0
10
0
10
0.00
0.21
0.0
2.7
—
0.3
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
10311.8
—
0
6
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
15
126
1.20
0.21
14.5
9.0
22.6
23.1
mmol/l
0.34
15
115
0
14
0.00
0.20
0.0
2.7
—
106.6
—
0
14
0
14
0.00
0.20
0.0
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
13
108
1.21
0.20
13.2
12.5
—
—
—
0
0
16
186
0.85
0.19
1.2
1.1
—
—
—
0
0
6
51
1.18
0.19
7.0
4.8
—
—
—
0
0
41
376
1.10
0.19
7.0
7.2
4.8
6.5
umol/l
0.95
35
313
7
58
1.21
0.18
3.3
8.0
5.7
4.8
kpa
—
7
58
7
58
1.21
0.18
3.4
8.0
8.0
9.2
kpa
—
7
58
74
780
0.94
0.17
4.0
3.4
—
—
—
0
0
170
1650
1.05
0.17
9.5
6.5
6.2
6.0
mmol/l
0.32
162
1540
5
69
0.72
0.17
4.2
1.7
—
—
—
0
0
52
486
1.08
0.17
1.3
1.7
—
—
—
0
0
11
92
1.20
0.16
1.5
1.7
—
—
—
0
0
214
2091
1.05
0.16
9.1
9.6
0.2
0.2
e9/l
0.97
184
1792
109
1048
1.05
0.15
1.8
1.8
—
—
—
0
0
22
197
1.12
0.15
1.2
1.1
12.4
6.6
u/ml
0.53
14
110
9
78
1.16
0.15
1.3
1.4
—
—
—
0
0
9
81
1.11
0.15
1.0
1.2
—
—
—
0
0
9
82
1.10
0.15
4.1
4.4
43.8
50.9
%
—
9
82
26
237
1.10
0.14
1.7
2.2
12.8
9.0
nmol/l
0.53
19
183
10
84
1.19
0.14
1.2
1.1
0.4
1.6
u/ml
—
5
23
255
2508
1.04
0.13
3.9
3.2
14.3
14.4
pmol/l
0.10
230
2236
9
109
0.82
0.13
5.6
3.7
—
—
—
0
0
51
483
1.06
0.12
1.3
1.7
—
—
—
0
0
18
162
1.12
0.12
1.1
1.1
—
—
—
0
0
46
435
1.06
0.11
3.2
2.4
20.7
16.3
ng/l
0.26
13
148
278
2814
0.97
0.11
4.3
3.6
2.0
2.0
mu/l
0.12
258
2638
42
444
0.94
0.11
2.5
1.7
—
—
—
0
0
12
136
0.88
0.11
1.1
1.2
—
—
—
0
0
51
486
1.06
0.10
1.3
1.7
—
—
—
0
0
14
125
1.12
0.10
12.5
13.8
0.7
0.7
%
0.11
14
125
139
1419
0.97
0.09
1.6
1.7
1.5
1.5
g/l
0.24
74
721
5
65
0.77
0.08
1.0
1.4
—
184.0
—
0
15
7
64
1.09
0.08
5.6
4.5
—
—
—
0
0
7
65
1.08
0.08
3.4
7.3
7.4
7.4
ph
—
7
58
56
580
0.96
0.07
2.2
1.8
—
—
—
0
0
9
105
0.85
0.06
3.2
2.1
—
—
—
0
0
50
483
1.04
0.06
1.3
1.7
—
—
—
0
0
33
345
0.95
0.06
1.2
1.2
2.1
10.2
u/ml
—
10
103
16
148
1.08
0.06
1.6
1.8
—
—
—
0
0
133
1308
1.02
0.06
2.3
2.1
—
—
—
0
0
30
313
0.95
0.05
1.3
1.2
3.0
3.0
u/ml
0.01
13
102
16
171
0.93
0.05
1.2
1.1
1.1
0.7
u/ml
—
8
74
73
715
1.02
0.04
3.9
3.4
7.6
7.3
e6/l
0.07
64
634
34
328
1.04
0.04
1.2
1.2
8.2
7.2
u/ml
0.11
25
245
19
180
1.06
0.04
1.2
1.1
26.5
10.1
u/ml
0.37
12
108
16
151
1.06
0.03
1.3
1.4
0.2
0.2
g/l
0.42
16
145
16
152
1.05
0.02
1.3
1.4
1.2
1.1
g/l
0.31
16
145
39
381
1.03
0.02
1.3
1.7
—
—
—
0
0
33
322
1.03
0.01
1.2
1.2
0.5
1.1
u/ml
1.28
24
230
75
741
1.01
0.01
2.4
3.3
78.5
112.8
ug/g
0.81
59
577
52
527
0.98
0.01
8.8
6.1
32.6
31.0
s
0.81
52
520
17
167
1.02
0.00
1.4
1.3
—
—
—
0
0
22
218
1.01
0.00
1.3
1.4
—
—
—
0
0
35
348
1.01
0.00
1.3
1.3
2.9
3.0
u/ml
0.02
24
225
23
228
1.01
0.00
1.2
2.0
—
—
—
0
0
18
184
0.98
0.00
1.0
1.0
—
—
—
0
0
12
115
1.04
0.00
1.0
1.1
—
—
—
0
0
12
116
1.03
0.00
1.0
1.1
—
—
—
0
0
96
959
1.00
0.00
2.4
2.1
—
—
—
0
0
37
373
0.99
0.00
1.2
1.2
8.8
14.9
iu/ml
—
6
82
25
251
1.00
0.00
1.5
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
1737.5
—
0
8
8
80
1.00
0.00
1.3
1.8
211.5
139.7
ng/l
—
8
75
0
9
0.00
0.00
0.0
5.1
—
138.3
—
0
9
7
76
0.92
0.00
1.0
1.3
—
—
—
0
0
7
73
0.96
0.00
7.4
6.0
2.0
2.1
ug/l
—
7
73
8
86
0.93
0.00
9.1
3.1
611.3
335.9
ug/l
—
8
76
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.4
1.1
—
—
—
0
0
7
78
0.90
0.00
5.1
7.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
8
85
0.94
0.00
1.6
1.3
—
—
—
0
0
8
81
0.99
0.00
4.1
4.0
2.6
3.3
e9/l
—
8
81
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
6
66
0.91
0.00
1.5
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
8
79
1.01
0.00
2.0
3.6
—
717.3
—
0
6
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
22.0
—
13.6
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
75.1
—
0
6
0
6
0.00
-0.00
0.0
3.5
—
13.2
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_INFECTIONS_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.84 [1.45, 2.34] < 0.001
Birth year 0.998 [0.99, 1.01] 0.613

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 16734 females with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.099 [0.9, 1.34] 0.351
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 23642 males with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_INFECTIONS_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.158% 0.199%
5 1.081% 1.32%
10 2.695% 3.159%
15 5.399% 6.062%
20 9.582% 10.507%

Relationships between endpoints

Index endpoint: P16_INFECTIONS_SPECIFIC_PERINA_PERIOD – Infections specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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