Other infections specific to the perinatal period

P16_OTH_INFECTIONS_SPECIFIC_PERINA_PERIOD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P39
  • Cause of death: ICD-10 P39

2 out of 7 registries used, show all original rules.

209

4. Check minimum number of events

None

209

5. Include endpoints

None

209

6. Filter based on genotype QC (FinnGen only)

209

Control definitions (FinnGen only)

Control exclude
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P3
Name in latin
Alii infectiones temporis perinatalis specificae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15148 6214 8934
Only index persons 9358 3723 5635
Unadjusted period prevalence (%)
Whole population 0.22 0.18 0.25
Only index persons 0.18 0.14 0.22
Median age at first event (years)
Whole population - 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 209 109 100
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
185
Matched controls
1860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
+∞
176.3
140
*
P39.1
ICD-10 Finland
Neonatal conjunctivitis and dacryocystitis
+∞
23.4
22
*
P39.4
ICD-10 Finland
Neonatal skin infection
+∞
11.6
11
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
+∞
11.6
11
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
14.5
9.9
16
12
P39.0
ICD-10 Finland
Neonatal infective mastitis
+∞
9.5
9
*
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
7.1
7.3
17
26

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
105
2.45
3.68
3.1
3.0
—
—
—
0
0
6
7
8.77
3.28
2.2
1.6
32.3
32.9
pg
—
6
7
20
89
2.38
2.97
6.5
6.2
0.0
0.0
%
—
5
23
20
92
2.30
2.77
6.4
6.1
0.0
0.0
%
—
5
28
0
69
0.00
2.65
0.0
5.1
—
—
—
0
0
20
96
2.20
2.52
6.4
6.0
0.2
0.6
%
—
5
31
22
116
2.00
2.20
1.4
1.4
—
—
—
0
0
45
300
1.64
2.11
3.5
3.4
0.0
0.0
estimate
0.00
22
108
36
226
1.71
2.11
3.6
4.6
—
—
—
0
0
0
55
0.00
2.10
0.0
1.1
—
—
—
0
0
43
293
1.59
1.84
3.5
3.4
7.4
7.4
ph
—
8
55
5
12
4.24
1.83
1.0
1.1
—
—
—
0
0
17
90
1.97
1.70
2.5
2.7
4.9
5.1
pmol/l
0.71
17
81
6
20
3.05
1.59
6.2
6.8
—
—
—
0
0
8
33
2.48
1.55
18.8
14.8
71.1
71.9
%
—
8
33
0
44
0.00
1.53
0.0
1.4
—
—
—
0
0
106
894
1.37
1.47
9.5
11.4
0.0
0.0
e9/l
0.00
82
677
24
365
0.61
1.45
2.3
3.7
—
—
—
0
0
155
1396
1.42
1.42
10.1
11.7
3.9
3.9
mmol/l
0.15
150
1341
174
1609
1.48
1.30
9.6
10.4
21.3
22.4
mg/l
0.16
116
1046
62
765
0.73
1.27
1.6
1.8
0.3
2.3
u/ml
3.70
11
142
43
318
1.44
1.27
3.5
2.8
—
—
—
0
0
13
70
1.91
1.26
1.5
1.3
—
—
—
0
0
6
25
2.44
1.25
1.7
4.8
8.5
9.1
kpa
—
6
25
6
25
2.44
1.25
1.7
4.8
5.6
4.9
kpa
—
6
25
13
222
0.56
1.23
1.6
1.7
—
—
—
0
0
154
1400
1.38
1.22
10.1
11.7
139.5
139.5
mmol/l
0.01
149
1354
22
143
1.60
1.17
2.2
2.3
7.0
5.7
u/l
0.45
16
100
5
20
2.53
1.15
1.2
1.1
—
—
—
0
0
8
40
2.04
1.13
18.8
13.1
—
—
—
0
0
8
41
1.99
1.10
4.1
3.9
2.6
3.1
e9/l
—
8
41
8
41
1.99
1.10
4.4
4.4
43.0
50.3
%
—
8
41
39
293
1.41
1.06
3.1
3.4
468.1
629.5
mosm/kgh2o
3.47
32
263
9
47
1.95
1.03
2.7
6.5
202.8
454.3
mg/l
—
9
47
124
1365
0.77
1.02
4.5
3.7
2.1
2.0
mu/l
0.41
111
1282
13
78
1.71
0.93
1.5
1.5
—
—
—
0
0
39
493
0.74
0.90
1.8
1.5
—
—
—
0
0
18
120
1.55
0.88
1.8
1.4
508.5
63809944.8
pmol/l
0.50
11
105
22
304
0.69
0.86
1.3
1.2
—
—
—
0
0
164
1538
1.30
0.82
12.6
14.6
13.2
13.0
%
1.29
157
1505
0
27
0.00
0.78
0.0
1.9
—
40.0
—
0
27
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
51
422
1.27
0.74
4.2
4.5
0.1
0.2
e6/l
1.05
34
323
13
85
1.56
0.70
1.5
1.5
—
—
—
0
0
51
426
1.26
0.69
4.4
4.4
—
—
—
0
0
7
43
1.65
0.67
3.1
6.8
—
—
—
0
0
54
458
1.24
0.64
4.9
4.6
17.5
27.4
e6/l
0.45
38
361
43
357
1.26
0.61
5.8
4.9
—
—
—
0
0
25
193
1.33
0.61
2.2
2.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
29.5
—
0
6
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
21.4
—
0
5
23
177
1.34
0.57
1.2
1.2
8.8
14.0
iu/ml
—
5
37
70
620
1.19
0.54
3.6
3.3
0.0
0.0
estimate
0.00
20
106
70
621
1.19
0.53
5.1
4.7
0.0
0.0
estimate
0.00
22
114
83
913
0.85
0.53
2.9
2.8
4.3
4.3
mmol/l
0.23
78
867
37
308
1.24
0.52
4.5
3.4
8.2
8.3
e6/l
0.01
30
275
11
75
1.49
0.51
1.0
1.0
—
—
—
0
0
81
891
0.85
0.51
2.7
2.7
1.4
1.4
mmol/l
0.40
75
840
190
1845
1.32
0.49
13.5
15.0
4.6
4.7
e12/l
0.11
174
1755
70
626
1.18
0.48
3.7
3.3
0.0
0.0
estimate
0.00
22
109
11
153
0.70
0.48
2.1
1.8
—
—
—
0
0
8
117
0.67
0.47
1.3
1.4
—
—
—
0
0
8
116
0.68
0.47
1.1
1.4
—
—
—
0
0
190
1847
1.30
0.47
13.5
15.0
6.8
6.6
e9/l
0.75
175
1756
22
272
0.79
0.45
1.3
1.9
—
—
—
0
0
22
271
0.79
0.44
1.3
1.8
—
—
—
0
0
22
271
0.79
0.44
1.3
1.9
—
—
—
0
0
22
271
0.79
0.44
1.3
1.9
—
—
—
0
0
189
1839
1.28
0.43
13.6
15.1
269.2
268.1
e9/l
0.08
173
1754
5
31
1.63
0.43
2.8
5.5
—
—
—
0
0
6
94
0.63
0.43
2.3
2.1
—
—
—
0
0
8
57
1.42
0.42
3.0
1.6
—
—
—
0
0
8
58
1.39
0.42
5.8
11.8
22.3
23.3
mmol/l
—
8
52
36
307
1.21
0.42
1.6
1.4
101.6
100.0
pmol/l
0.07
19
161
5
33
1.53
0.41
1.2
1.4
—
—
—
0
0
78
849
0.87
0.41
2.7
2.6
1.3
1.1
mmol/l
1.08
73
809
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
62
685
0.86
0.40
1.5
1.7
1.7
1.6
g/l
0.13
33
359
115
1217
0.88
0.40
4.3
3.3
14.4
14.3
pmol/l
0.10
102
1086
0
19
0.00
0.39
0.0
2.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
27
320
0.82
0.39
1.4
1.6
—
—
—
0
0
17
212
0.78
0.38
1.3
1.9
—
—
—
0
0
21
252
0.81
0.34
1.3
1.9
—
—
—
0
0
61
554
1.14
0.34
5.7
5.2
67.7
62.4
e6/l
0.04
39
372
6
89
0.66
0.33
3.8
1.3
3.1
3.9
e9/l
—
6
83
30
258
1.19
0.33
4.9
8.1
—
—
—
0
0
74
796
0.89
0.31
4.5
3.5
75.6
51.4
ug/l
0.36
69
747
69
636
1.13
0.31
2.2
2.1
—
—
—
0
0
108
1023
1.11
0.30
4.7
4.6
8.7
6.7
mm/h
0.68
102
948
89
944
0.90
0.29
2.1
2.2
5.6
5.3
mmol/l
0.43
75
848
172
1674
1.15
0.29
11.5
13.1
39.7
39.9
%
0.13
143
1480
74
791
0.90
0.28
3.5
2.9
36.8
36.6
mmol/mol
0.05
69
744
76
712
1.10
0.25
7.7
10.1
—
—
—
0
0
30
265
1.15
0.25
1.4
1.7
—
—
—
0
0
55
507
1.11
0.24
3.4
3.2
—
—
—
0
0
33
295
1.14
0.24
7.5
12.8
—
—
—
0
0
5
38
1.32
0.23
1.4
1.4
—
—
—
0
0
32
286
1.14
0.23
2.7
1.7
—
—
—
0
0
8
104
0.76
0.21
1.1
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
34.7
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
5.5
—
0.6
—
0
10
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
28.9
—
0
10
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
156
1596
0.91
0.21
11.6
13.9
335.3
335.3
g/l
0.00
156
1573
0
13
0.00
0.21
0.0
2.6
—
18.7
—
0
13
38
348
1.11
0.19
2.8
2.3
—
—
—
0
0
93
892
1.07
0.17
4.5
4.2
—
—
—
0
0
86
895
0.93
0.16
2.7
2.7
2.6
2.6
mmol/l
0.19
80
839
6
77
0.77
0.16
1.0
1.9
—
—
—
0
0
35
323
1.10
0.15
12.4
13.0
25.0
25.1
mmol/l
0.04
35
323
34
367
0.91
0.15
2.9
3.7
128.7
91.2
ug/g
0.43
26
282
9
82
1.10
0.15
1.2
1.1
—
—
—
0
0
19
169
1.14
0.15
1.2
1.1
1.0
9.6
u/ml
—
5
56
51
481
1.08
0.14
4.8
8.0
12.5
12.5
umol/l
0.00
45
444
163
1600
1.08
0.14
7.3
7.4
—
—
—
0
0
11
128
0.85
0.14
1.2
2.3
—
—
—
0
0
25
228
1.11
0.14
1.3
1.4
—
13.1
—
0
8
17
151
1.14
0.13
1.4
1.5
—
—
—
0
0
96
990
0.94
0.13
8.5
10.4
0.2
0.2
e9/l
0.16
82
852
34
363
0.92
0.12
2.0
1.7
—
—
—
0
0
94
968
0.95
0.12
8.2
9.7
0.0
0.0
e9/l
2.06
79
817
94
968
0.95
0.12
8.1
9.7
0.6
0.5
e9/l
0.54
79
816
48
504
0.94
0.11
1.6
1.8
—
—
—
0
0
5
47
1.06
0.09
1.4
4.6
28.2
28.2
%
—
5
47
34
321
1.07
0.09
9.9
11.3
0.7
1.4
mmol/l
0.57
28
258
6
53
1.13
0.09
1.3
1.2
—
—
—
0
0
6
58
1.03
0.08
11.7
14.5
97.4
95.1
%
—
6
58
10
88
1.14
0.08
1.2
1.1
—
—
—
0
0
8
75
1.07
0.07
1.3
1.6
—
—
—
0
0
7
82
0.85
0.07
1.1
1.3
—
—
—
0
0
33
314
1.06
0.07
2.4
1.8
—
—
—
0
0
34
324
1.06
0.07
10.0
11.2
6.0
5.9
kpa
0.07
34
310
8
92
0.86
0.07
3.1
10.7
0.1
0.3
g/l
—
8
77
52
536
0.96
0.06
6.0
10.7
—
—
—
0
0
88
863
1.03
0.05
6.2
5.4
116.3
117.5
u/l
0.05
82
806
98
995
0.97
0.05
7.9
9.6
2.2
2.1
e9/l
0.26
84
861
35
337
1.05
0.05
2.9
3.2
—
—
—
0
0
15
141
1.07
0.03
1.4
1.2
4.0
3.0
u/ml
—
9
38
104
1027
1.02
0.03
9.1
11.3
3.5
3.4
e9/l
0.20
87
868
32
329
0.97
0.02
3.2
2.9
1.0
1.0
kg/l
—
6
37
27
261
1.04
0.02
1.9
1.6
—
—
—
0
0
42
411
1.03
0.02
2.7
3.8
2.6
2.7
mg/l
0.10
37
361
32
312
1.03
0.01
10.1
10.9
5.3
5.0
kpa
0.40
32
299
18
187
0.96
0.01
1.3
2.4
—
—
—
0
0
14
133
1.06
0.01
1.6
1.9
239.1
175.0
u/ml
—
8
59
24
234
1.03
0.00
2.9
5.4
0.5
1.4
mg/l
1.33
14
161
51
515
0.99
0.00
2.7
2.1
—
—
—
0
0
22
215
1.02
0.00
10.4
14.3
6.1
5.1
mmol/l
0.56
22
210
16
159
1.01
0.00
1.3
1.3
3.9
3.1
u/ml
0.08
11
99
30
300
1.00
0.00
2.5
4.1
1.1
1.1
inr
1.24
18
97
17
168
1.01
0.00
2.8
3.2
2143.7
1350.3
ng/l
—
7
85
21
213
0.98
0.00
2.3
2.3
13.6
15.8
ng/l
—
7
69
12
123
0.97
0.00
1.4
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
20.6
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2000.0
—
0
5
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
107.6
—
0
5
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
69
1.01
0.00
2.0
4.2
—
—
—
0
0
0
7
0.00
0.00
0.0
4.4
—
4.3
—
0
7
0
6
0.00
0.00
0.0
2.5
—
3.5
—
0
6
5
49
1.02
0.00
11.4
13.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
6
60
1.00
0.00
11.7
14.1
0.9
1.2
%
—
6
60
5
49
1.02
0.00
1.4
4.4
67.4
68.8
%
—
5
49
6
60
1.00
0.00
11.7
14.1
0.6
0.7
%
—
6
60
0
7
0.00
0.00
0.0
12.4
—
46.4
—
0
7
0
7
0.00
0.00
0.0
8.1
—
647.4
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
0.00
1.4
4.9
22.6
16.5
%
—
5
56
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
0.00
13.6
14.5
24.0
24.1
mmol/l
—
5
58
5
57
0.87
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
107.3
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_OTH_INFECTIONS_SPECIFIC_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_INFECTIONS_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_OTH_INFECTIONS_SPECIFIC_PERINA_PERIOD – Other infections specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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