Congenital malformations of larynx

Q17_CONGEN_MALFO_LARYNX

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Q31 Cause of death: ICD-10 — Q31 2 out of 7 registries used, show all original rules.	109
4. Check minimum number of events None	109
5. Include endpoints None	109
6. Filter based on genotype QC (FinnGen only)	102

Control definitions (FinnGen only)

Control exclude: Q17_CONGEN_MALFO_RESPI_SYSTEM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Q3[0-4]
Name in latin: Malformationes congenitae laryngis

NAME	Q17_CONGEN_MALFO_LARYNX
CONTROL_EXCLUDE	Q17_CONGEN_MALFO_RESPI_SYSTEM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q31
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q31
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Congenital malformations of larynx based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2624	1091	1532
Only index persons	1351	574	777
Unadjusted period prevalence (%)
Whole population	0.04	0.03	0.04
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	0.34	0.30	0.37
Only index persons	0.49	0.48	0.49

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	102	53	49
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	9.68	17.88	0.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
109: Matched controls
1089

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Q31.40

ICD-10 Finland

Congenital laryngomalasia

956.8

58.3

Q31.3

ICD-10 Finland

Laryngocele

+∞

29.5

Q31.1

ICD-10 Finland

Congenital subglottic stenosis

+∞

16.0

UGC02

NOMESCO Finland

Rigid bronchoscopy

53.3

15.6

UGC12

NOMESCO Finland

Flexible bronchoscopy

13.3

14.7

DQB10

NOMESCO Finland

Endoscopic excision of lesion of larynx

+∞

12.7

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.0

11.7

285

WX408

NOMESCO Finland

General anesthesy, balanced

3.4

9.0

223

WX402

NOMESCO Finland

General anaesthesia

3.3

8.1

199

EN1BD

NOMESCO Finland

Very extensive CT examination of mouth and soft tissues of neck

85.6

7.5

R06.1

ICD-10 Finland

Stridor

85.6

7.5

UGB02

NOMESCO Finland

Tracheoscopy

85.6

7.5

UDQ22

NOMESCO Finland

Microlaryngoscopy

+∞

7.4

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

4.8

7.0

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.4

7.0

114

UDQ02

NOMESCO Finland

Direct laryngoscopy

18.1

6.9

Z01.8

ICD-10 Finland

Other specified special examinations

3.2

6.6

137

Z3229

NOMESCO Finland

Other healthcare associate professional

3.7

6.5

Q32.0

ICD-10 Finland

Congenital tracheomalacia

+∞

6.3

Q31.48

ICD-10 Finland

Other congenital laryngeal warts

+∞

6.3

DQW99

NOMESCO Finland

Other operation on larynx

+∞

6.3

J38.6

ICD-10 Finland

Stenosis of larynx

+∞

6.3

DQD40

NOMESCO Finland

Plastic repair of larynx

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3006315) Basophils [#/volume] in Blood

540

2.45

4.37

7.7

9.8

0.04

e9/l

0.54

424

(3001604) Monocytes [#/volume] in Blood

542

2.32

3.97

7.8

9.7

0.58

0.60

e9/l

0.38

426

(3023368) Bacteria identified in Blood by Culture

182

2.36

3.93

4.0

4.3

—

(3013115) Eosinophils [#/volume] in Blood

557

2.30

3.82

8.8

10.7

0.19

0.22

e9/l

0.76

457

(3019198) Lymphocytes [#/volume] in Blood

552

2.24

3.66

7.9

9.8

2.25

2.49

e9/l

0.87

453

(3013650) Neutrophils [#/volume] in Blood by Automated count

595

2.29

3.60

10.2

12.4

3.85

3.66

e9/l

0.35

485

(4062490) Immunoglobulin typing, IgG

5.66

3.25

1.1

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

125

2.30

3.01

2.3

1.6

—

(3022313) Gas panel - Capillary blood

196

2.07

2.87

10.8

10.9

—

(3042936) Bacteria identified in Isolate by Culture

113

2.31

2.87

1.7

2.0

—

(3037522) Nuclear Ab [Titer] in Serum

101

2.33

2.75

1.4

1.6

264.00

534.74

titre

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.27

2.73

1.7

1.6

—

(40768804) Tissue Pathology biopsy report

234

1.96

2.65

2.0

1.8

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.22

2.43

1.3

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

184

1.95

2.38

2.6

3.5

80.99

20.40

ng/l

0.44

(40760892) CBC W Ordered Manual Differential panel - Blood

508

1.82

2.36

9.5

10.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

138

2.05

2.34

3.9

6.2

483.16

1141.86

ng/l

2.27

120

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.04

2.27

1.6

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.04

2.27

1.6

1.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

5.75

2.23

1.4

1.0

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

223

1.84

2.15

12.1

11.3

1.54

1.12

mmol/l

0.65

167

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

5.17

2.09

1.4

253.60

1135.00

pmol/l

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

5.17

2.09

1.0

1.7

—

(3000475) Leukocytes [#/volume] in Synovial fluid

5.17

2.09

2.2

2.0

29915.60

20336.20

e6/l

—

(3000991) Gas panel - Venous blood

192

1.86

2.08

17.8

12.3

—

(4200892) Spirometry reversibility

2.45

2.06

1.8

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.23

2.05

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

572

1.76

2.03

5.1

4.5

—

(40761536) Microorganisms panel - Urine sediment

2.52

2.03

3.4

4.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.55

1.92

2.1

1.3

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

2.79

1.91

2.3

1.9

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

2.79

1.91

2.3

1.9

—

(3021589) Normoblasts [#/volume] in Blood

528

1.69

1.89

12.9

11.2

0.00

0.03

e9/l

0.51

380

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.67

1.86

1.5

1.9

—

(3038515) Glucose [Moles/volume] in Venous blood

4.31

1.84

3.4

4.3

6.04

6.77

mmol/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

481

1.67

1.83

24.4

12.7

1.23

mmol/l

0.04

436

(3000494) Fungus identified in Specimen by Culture

2.08

1.82

1.8

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.37

1.81

11.4

2.8

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.37

1.81

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

351

1.65

1.77

4.0

4.6

—

(3024928) Oxygen saturation in Venous blood

2.79

1.76

13.1

25.4

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

2.79

1.76

1.3

1.5

—

(3012544) pH of Venous blood

210

1.74

1.75

9.4

11.8

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.04

1.75

1.3

1.5

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.97

1.73

2.6

2.1

—

(3008037) Lactate [Moles/volume] in Venous blood

3.97

1.73

4.4

4.1

1.40

1.18

mmol/l

—

(3002032) Base excess in Venous blood by calculation

212

1.72

1.69

8.8

11.3

1.47

0.91

mmol/l

0.35

160

(3022217) INR in Platelet poor plasma by Coagulation assay

275

1.65

1.63

5.9

9.1

1.21

1.12

inr

0.20

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.17

1.61

1.6

2.9

26.73

14.34

iu/l

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.11

1.60

1.0

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

251

1.65

1.57

3.5

3.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.20

1.55

9.5

16.8

0.50

0.67

0.99

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

110

1.88

1.55

2.2

1.9

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

193

1.68

1.50

6.4

10.5

24.17

23.21

mmol/l

1.13

193

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

1.76

1.47

2.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

2.42

1.47

2.3

2.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

2.42

1.47

2.3

2.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.12

1.44

9.5

16.3

1.19

1.30

0.13

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.70

1.38

1.3

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.24

1.37

2.4

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

115

1.79

1.35

2.2

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

342

1.54

1.34

3.6

3.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.19

1.34

2.8

2.0

—

(36304419) Bacteria [Presence] in Urine

299

1.53

1.27

3.5

4.4

—

(40758558) Short blood count panel - Blood

327

1.52

1.26

4.3

8.7

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.14

1.26

6.9

6.6

0.80

0.37

—

(40767503) Oxygen content in Capillary blood by calculation

2.70

1.23

2.0

3.2

16.72

18.03

—

(3002582) Erythrocytes [#/volume] in Urine

329

1.51

1.22

4.0

4.4

24.70

18.21

e6/l

0.28

238

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

111

1.74

1.21

1.4

1.2

18.00

15.75

iu/ml

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

195

1.58

1.20

1.5

1.6

102.98

93.73

pmol/l

0.67

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.38

1.20

1.5

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

188

1.58

1.16

5.4

4.2

0.00

estimate

-0.00

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.42

1.14

1.4

1.8

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.42

1.14

12.6

22.8

75.86

72.34

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

105

1.73

1.14

1.3

1.2

54.90

6.20

u/ml

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

198

1.56

1.13

3.7

3.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.44

1.10

1.2

1.1

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.99

1.05

8.6

7.9

71.39

59.61

—

(3002385) Erythrocyte distribution width [Ratio]

883

1.72

1.02

23.7

17.8

14.72

13.89

0.71

876

(3022948) Iron [Moles/volume] in Serum or Plasma

125

1.63

1.02

4.9

3.4

15.45

14.46

umol/l

0.27

118

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.07

1.02

1.3

1.5

—

(3017181) Myelocytes/100 leukocytes in Blood

1.94

1.00

11.0

7.5

0.40

0.46

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.99

0.0

2.1

—

0.43

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.99

0.0

1.2

—

87.00

—

(3000492) Spirometry study

1.80

0.97

1.3

1.5

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.90

0.95

1.8

3.1

10.22

6.43

u/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

119

1.61

0.95

4.9

4.2

550.77

682.20

ng/l

0.15

(3021901) Oxygen saturation in Capillary blood

2.29

0.95

2.2

6.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.21

0.93

1.2

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

307

1.42

0.92

3.9

4.4

0.25

0.31

e6/l

0.15

213

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

261

1.44

0.92

3.7

5.5

29.38

33.64

u/l

0.86

251

(3003458) Phosphate [Moles/volume] in Serum or Plasma

207

1.47

0.91

18.4

9.9

1.30

1.38

mmol/l

0.49

198

(3014007) Fractional oxyhemoglobin in Arterial blood

1.88

0.88

50.3

18.9

95.88

94.48

—

(3018418) pH of Serum or Plasma

200

1.46

0.87

4.9

3.4

7.43

7.41

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.83

0.86

1.4

1.6

—

(40761511) CBC panel - Blood by Automated count

906

1.63

0.81

16.4

9.8

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.72

0.80

47.8

17.2

24.75

24.40

mmol/l

—

(3003985) Beta hydroxybutyrate [Moles/volume] in Serum or Plasma

0.00

0.80

0.0

2.3

—

2.41

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.80

0.0

4.7

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.79

0.0

6.1

—

2.47

—

(3018095) Leukocytes [#/volume] in Urine

373

1.35

0.76

5.4

5.6

36.07

30.50

e6/l

0.08

249

(3035637) Corticotropin [Mass/volume] in Plasma

1.69

0.76

2.9

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

2.13

0.75

1.6

1.7

—

(3011648) Oxygen content in Venous blood

2.13

0.75

12.6

27.7

12.76

11.35

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.04

0.73

2.6

1.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.89

0.69

1.0

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.63

0.66

51.0

17.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

239

1.35

0.65

21.8

16.3

24.77

24.67

mmol/l

0.07

239

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.62

0.61

1.7

2.5

0.56

0.70

ug/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.60

0.0

1.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

107

1.46

0.59

2.4

4.5

0.18

0.20

g/l

0.60

102

(3003338) MCHC [Mass/volume]

887

1.43

0.57

20.6

18.2

333.99

335.08

g/l

0.46

881

(3013512) EKG study

143

1.40

0.57

4.8

3.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.54

0.56

2.8

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.61

0.55

1.2

3.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

109

1.43

0.54

15.6

13.2

107.20

104.28

mmol/l

2.28

109

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

547

1.26

0.53

14.3

9.9

94.56

92.99

ml/min/173m2

0.14

409

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

1.38

0.47

3.4

1.5

—

(3044889) 12 lead EKG panel

453

1.23

0.46

3.6

2.9

—

(3023520) Reticulocytes [#/volume] in Blood

1.42

0.46

2.5

5.7

91.90

66.34

e9/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

186

1.30

0.45

3.2

2.1

—

(3022145) Colonoscopy Study observation

1.46

0.44

1.4

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.64

0.43

1.6

1.4

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

1.64

0.43

2.6

4.7

—

(3028707) Methadone [Presence] in Urine by Screen method

1.59

0.43

1.6

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.38

0.42

3.0

2.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

1.54

0.42

1.8

1.5

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.41

0.0

1.7

—

175.53

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.2

—

1.57

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.7

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.41

0.0

1.1

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.7

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

5.3

—

1.96

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.9

—

11.63

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

5.3

—

4.75

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

5.3

—

9.18

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.6

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

0.39

0.0

1.4

—

22.06

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

333

1.22

0.38

1.8

1.9

—

(40768797) Stomach Pathology biopsy report

1.43

0.38

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

166

0.75

0.36

3.0

2.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.42

0.35

1.2

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

147

1.27

0.33

3.1

1.6

—

(1761868) Lipid panel - Serum or Plasma

205

0.80

0.31

2.9

2.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.34

0.31

10.0

5.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.31

0.29

1.1

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

104

1.28

0.28

2.0

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

158

0.80

0.26

2.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.22

0.25

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

901

1.21

0.24

21.4

13.1

26.96

23.69

mg/l

0.35

641

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

278

1.16

0.23

5.4

3.8

—

(3003396) Base excess in Arterial blood by calculation

1.29

0.23

41.4

12.7

0.54

1.03

mmol/l

—

(3025941) Bacteria identified in Stool by Culture

1.26

0.22

1.6

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

788

1.16

0.22

3.8

3.7

—

(3011288) Drugs identified in Urine by Screen method

1.20

0.22

1.8

1.7

—

(3002256) Pathology report gross observation

1.26

0.21

1.3

1.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.21

0.0

1.4

—

85.70

—

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

7.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

4.1

—

81.80

—

(3010015) Selenium [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

1.11

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

0.00

0.21

0.0

4.9

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.21

0.0

1.8

—

94.27

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.1

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.7

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

0.00

0.21

0.0

4.9

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.8

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

70.28

—

(40761535) Cells panel - Urine sediment

1.24

0.20

5.3

4.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.20

0.0

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.20

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.19

0.20

1.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.16

0.19

3.2

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

333

1.12

0.17

1.5

1.8

1.89

1.65

g/l

0.33

171

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

216

1.14

0.17

2.8

4.1

1.11

0.53

e6/l

0.34

126

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

168

1.16

0.17

3.3

4.8

2.45

1.60

mg/l

0.29

135

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.79

0.16

3.7

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

102

1.20

0.16

1.0

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

237

1.13

0.15

5.2

4.2

—

(3009261) Glucose [Presence] in Urine by Test strip

418

1.09

0.12

5.7

4.1

0.00

estimate

-0.00

(3003694) ABO and Rh group [Type] in Blood

270

1.10

0.12

1.6

1.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

115

1.15

0.11

6.6

3.4

2.51

2.57

g/l

0.12

108

(3035350) Ketones [Presence] in Urine by Test strip

410

1.08

0.10

5.7

4.1

0.00

estimate

-0.00

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

1.14

0.10

1.0

173.00

165.41

g/l

—

(3019225) pH of Specimen

1.09

0.10

26.8

3.7

—

(3044290) Cell count panel - Cerebral spinal fluid

1.04

0.09

1.6

4.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.14

0.09

3.5

2.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.07

0.09

1.8

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.82

0.08

1.6

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.08

0.08

1.6

1.4

—

(3027008) Opiates [Presence] in Urine

1.06

0.08

1.6

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.06

0.08

1.6

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.06

0.08

4.7

8.7

150.71

170.82

—

(3028300) Cannabinoids [Presence] in Urine

1.05

0.08

1.6

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.02

0.07

3.0

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

197

1.08

0.06

4.3

3.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

415

1.06

0.06

8.0

6.0

0.00

estimate

-0.00

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

342

0.95

0.05

1.4

1.7

1.60

1.64

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

209

1.06

0.04

3.4

4.3

2.90

1.46

e6/l

—

121

(3015736) pH of Urine

350

0.96

0.03

4.6

3.9

6.00

6.21

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

226

0.97

0.01

2.0

—

(3026008) Bacteria identified in Urine by Culture

227

1.02

0.00

4.0

3.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

488

1.01

0.00

3.8

4.6

41.29

36.75

u/l

0.32

468

(36660697) Celiac disease serology panel - Serum

152

0.98

0.00

1.1

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.06

0.00

1.0

1.1

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.9

—

7.86

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3020047) Haemophilus influenzae B Ab [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

0.77

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

5.2

—

314.00

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

38266.67

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

11.2

—

8.62

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

3.07

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

209.83

—

(3006598) pH of Arterial cord blood

0.98

-0.00

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.9

—

(42870560) Thyrotropin [Units/volume] in Cord blood

0.98

-0.00

1.0

12.86

8.58

mu/l

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

87.56

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

12.1

—

609.44

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.90

-0.00

2.6

2.5

—

9697.25

u/l

—

(3009410) PHENobarbital [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

16.6

—

104.20

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.45

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.95

-0.00

2.0

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.98

-0.00

3.2

1.9

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.3

—

13.57

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.0

—

50.20

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.9

—

(3016879) Cocaine [Presence] in Urine

0.95

-0.00

1.7

1.4

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

-0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3019977) pH of Arterial blood

0.00

-0.00

0.0

1.3

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

1.01

-0.00

1.0

2.84

3.25

kpa

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.7

—

51.83

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.99

-0.00

6.4

9.3

82.00

90.59

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

2.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

2.86

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.6

—

(3035400) Alkaline phosphatase.liver [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

49.80

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

-0.00

0.0

3.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.98

-0.00

1.0

8.27

7.50

kpa

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

246.00

—

(3045684) Alkaline phosphatase.other fractions [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

19.40

—

(4035726) Immunohistochemistry procedure

0.93

-0.00

1.8

1.6

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.1

—

(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.0

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

23.00

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3033882) Carnitine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

31.25

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.3

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_MALFO_LARYNX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_MALFO_LARYNX.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_MALFO_LARYNX – Congenital malformations of larynx

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Congenital malformations of larynx

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints