Osteosarcoma, including Hilmo

C3_OSTEOSARCOMA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C40.1|C4103|C4107|C4113|C4121|C4131|C4141|C4181|C4191
  • Cause of death: ICD-10 C40.1|C4103|C4107|C4113|C4121|C4131|C4141|C4181|C4191
  • Cancer registry: Topography ICD-O-3 C4[0-1]
  • Cancer registry: Morphology ICD-O-3 9180|9181|9183|9200|9261
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

138

4. Check minimum number of events

None

138

5. Include endpoints

None

138

6. Filter based on genotype QC (FinnGen only)

134

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 134 59 75
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 36.56 29.16 42.39

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
86.9
74
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
59.8
53
*
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
58.6
52
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
218.8
55.5
54
*
A03FA01
ATC
metoclopramide; systemic, rectal
11.7
42.0
55
74
N02AA05
ATC
oxycodone; systemic
11.1
41.3
57
82
H02AB02
ATC
dexamethasone; systemic
115.9
33.5
35
*
GD1AD
NOMESCO Finland
Thorax CT examination
16.4
33.4
31
24
JN4BD
NOMESCO Finland
Extensive body CT
14.1
32.4
33
30
L03AA02
ATC
filgrastim; parenteral
332.6
27.8
27
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
90.8
27.0
29
*
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
27.0
25
*
A04AA01
ATC
ondansetron; systemic, rectal
35.6
25.9
33
12
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
24.7
23
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
24.7
23
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
32.8
23.9
31
12
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
25.1
23.6
33
17
NF3AA
NOMESCO Finland
Femur X-ray examination
30.3
23.4
31
13
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.9
22.9
27
30
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.7
22.7
91
348
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.3
22.6
50
114
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
22.5
21
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
21.4
20
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
21.4
20
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
8.6
21.3
31
45
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
50.3
21.3
25
6
B01AB05
ATC
enoxaparin; parenteral
5.2
20.4
66
208
L03AA13
ATC
pegfilgrastim; parenteral
231.9
20.1
20
*
ZXE20
NOMESCO Finland
More than three and less than five hours
6.0
18.8
41
91
WX306
NOMESCO Finland
Lumbar epidural anesthesy
8.1
18.1
27
40
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
18.1
17
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
18.1
17
*
Z51.5
ICD-10 Finland
Palliative care
34.1
18.1
23
8
WX408
NOMESCO Finland
General anesthesy, balanced
4.7
17.6
59
188
R4110
NOMESCO Finland
Physiotherapy
4.6
17.4
61
201
JN4AD
NOMESCO Finland
Body CT examination
15.0
17.3
29
24
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
17.0
16
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
17.0
16
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
17.0
16
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
17.0
16
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
54.6
16.5
19
*
WX402
NOMESCO Finland
General anaesthesia
5.0
16.2
45
122
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
15.9
15
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.9
15.7
33
70
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
51.3
15.5
18
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.2
15.4
68
261
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
14.8
14
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
14.3
14.8
25
21
A04AA02
ATC
granisetron; systemic, transdermal
166.9
14.8
15
*
WW500
NOMESCO Finland
Blood transfusion
18.4
14.5
22
14
N03AX16
ATC
[U] pregabalin
4.2
14.2
52
173
WZC00
NOMESCO Finland
Treatment plan or consultation
3.9
14.0
70
289
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
83.3
13.9
15
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
+∞
13.8
13
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
12.8
29
65
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
12.7
12
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
142.4
12.7
13
*
ZXA05
NOMESCO Finland
Left side
3.9
12.5
51
181
ZXE00
NOMESCO Finland
One hour or less
3.5
12.0
74
343
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
11.6
11
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
11.6
11
*
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
11.6
11
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.1
11.4
27
63
B01AB10
ATC
tinzaparin; parenteral
6.2
11.3
21
39
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.9
11.2
41
134
ZXE30
NOMESCO Finland
More than five and less than seven hours
10.1
10.7
21
24
TPX15
NOMESCO Finland
Removal of vascular injection port
118.7
10.6
11
*
NER30
NOMESCO Finland
Extended excision of soft tissue tumour of pelvis
+∞
10.5
10
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.5
10
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
10.5
10
*
C41.41
ICD-10 Finland
Osteosarcoma of the pelvic bones, sacrum and coccyx
+∞
10.5
10
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
+∞
10.5
10
*
115
Kela drug reimbursment
Breast cancer
+∞
10.5
10
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
10.5
10
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.5
10.4
47
176
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.2
10.2
23
51
WX302
NOMESCO Finland
Thoracal epidural anesthesy
18.5
10.1
15
9
J04AB02
ATC
rifampicin; systemic
59.3
9.8
11
*
XX3DW
NOMESCO Finland
Time consuming IT work
9.8
9.7
19
22
JN4CD
NOMESCO Finland
Very extensive body CT
32.6
9.6
12
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
107.1
9.5
10
*
ZXA00
NOMESCO Finland
Right side
3.3
9.5
49
198
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
9.5
9
*
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
9.5
9
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
9.5
9
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.5
9
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
+∞
9.5
9
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
9.5
9
*
9101
FHL
Bone biopsy
+∞
9.5
9
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
15.1
9.4
15
11
ZXE40
NOMESCO Finland
More than seven and less than nine hours
15.1
9.4
15
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
9.1
28
80
ZZA00
NOMESCO Finland
Split skin graft
15.4
8.9
14
10
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
17.8
8.7
13
8
R4120
NOMESCO Finland
Occupational therapy
5.2
8.6
19
41
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
10.5
8.5
16
17
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
C41.4
ICD-10 Finland
Malignant neoplasm: Pelvic bones, sacrum and coccyx
+∞
8.4
8
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
8.4
8
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.1
8.4
20
32
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
8.4
64
320
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
35.7
8.2
10
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.0
8.2
19
43
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.1
8.1
25
71
WZC30
NOMESCO Finland
Teaching
3.9
8.0
27
82
WX002
NOMESCO Finland
Sedation and analgesia
3.4
7.9
34
122
D70.82
ICD-10 Finland
Drug-induced neutropenia
47.7
7.8
9
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
47.7
7.8
9
*
ZX120
NOMESCO Finland
Intravenous
4.5
7.6
20
50
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
84.4
7.5
8
*
R50.9
ICD-10 Finland
Fever, unspecified
3.3
7.5
33
120
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.7
7.4
18
30
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
7.4
7
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
7.4
7
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
7.4
7
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
+∞
7.4
7
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
7.4
7
*
C40.31
ICD-10 Finland
Osteosarcoma of the short bones of the lower extremity
+∞
7.4
7
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
7.4
7
*
C40.81
ICD-10 Finland
Overall osteosarcoma of the extremities' bones and articular cartilage
+∞
7.4
7
*
L71
ICPC
Malignant neoplasm musculoskeletal
+∞
7.4
7
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
7.4
7
*
C49.20
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the lower extremity including the hip without histology
+∞
7.4
7
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
7.4
7
*
Z89.6
ICD-10 Finland
Acquired absence of leg above knee
+∞
7.4
7
*
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
+∞
7.4
7
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
7.4
7
*
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
7.4
7
*
C41.91
ICD-10 Finland
Osteosarcoma in unspecified localization in bone and articular cartilage
+∞
7.4
7
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
11.8
6.9
12
11
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
23.9
6.8
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
6.7
43
192
NB6AA
NOMESCO Finland
Humerus X-ray examination
13.1
6.7
11
9
J01FF01
ATC
clindamycin; systemic
2.7
6.6
45
208
B01AB04
ATC
dalteparin; parenteral
7.2
6.5
15
23
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.8
6.5
13
16
NFQ48
NOMESCO Finland
Revision of exarticulation or amputation stump of hip or femur
73.1
6.5
7
*
NB1DG
NOMESCO Finland
Shoulder and humerus very extensive MRI examination with high intensity magnet
73.1
6.5
7
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
19.1
6.4
9
5
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
19.1
6.4
9
5
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
28.1
6.3
8
*
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
28.1
6.3
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
A79
ICPC
Malignancy NOS
+∞
6.3
6
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
+∞
6.3
6
*
GDB10
NOMESCO Finland
Wedge resection of lung
+∞
6.3
6
*
NF3AD
NOMESCO Finland
Femur CT
+∞
6.3
6
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.1
6.2
16
29
J01MA12
ATC
levofloxacin; systemic
3.0
6.2
31
121

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
29
14.64
33.07
2.0
1.4
—
—
—
0
0
83
316
5.08
20.16
3.8
1.6
—
—
—
0
0
17
0
+∞
18.11
32.5
0.0
0.37
—
umol/l
—
17
0
28
49
6.91
16.13
15.8
9.5
0.87
0.72
%
0.90
28
49
28
50
6.77
15.81
15.6
9.4
1.25
1.57
%
0.64
28
50
82
355
4.23
15.75
10.1
4.7
35.06
36.39
g/l
1.31
77
333
70
272
4.19
15.65
5.9
2.0
—
—
—
0
0
88
405
4.24
15.39
23.8
6.7
1.20
1.21
mmol/l
0.75
82
371
35
83
5.31
14.65
1.5
1.1
—
—
—
0
0
61
226
4.05
14.37
7.9
3.5
—
—
—
0
0
91
445
4.07
14.22
26.1
7.1
1.21
1.21
mmol/l
0.55
77
398
36
95
4.77
13.20
13.1
7.5
5.44
5.10
kpa
0.84
36
90
36
95
4.77
13.20
13.1
7.5
14.25
11.74
kpa
1.70
36
90
28
67
4.99
11.45
46.1
11.7
25.34
24.50
mmol/l
0.75
28
67
35
106
4.08
10.59
30.9
6.1
104.66
104.39
mmol/l
0.12
35
106
81
427
3.17
10.08
13.6
11.7
1.10
1.29
inr
1.39
23
113
20
40
5.68
9.91
3.6
1.7
28.71
2.54
ug/l
0.49
15
28
41
145
3.60
9.88
2.7
1.7
—
—
—
0
0
26
67
4.55
9.66
2.9
3.6
0.21
0.21
g/l
0.03
26
62
57
255
3.10
9.29
8.2
3.4
7.41
7.40
ph
0.49
14
32
97
591
3.16
8.95
30.7
7.6
3.85
4.23
e9/l
0.80
86
511
19
40
5.35
8.89
14.2
9.4
—
—
—
0
0
34
121
3.40
7.98
2.2
1.8
—
—
—
0
0
52
254
2.68
6.87
24.8
6.0
—
—
—
0
0
27
93
3.37
6.60
27.9
8.5
—
—
—
0
0
79
489
2.44
6.14
17.2
6.7
—
—
—
0
0
83
529
2.43
6.00
13.5
6.1
0.52
0.56
e9/l
0.88
76
457
83
529
2.43
6.00
13.5
6.1
0.03
0.04
e9/l
1.29
76
455
84
542
2.41
5.85
13.5
6.2
1.54
1.90
e9/l
4.73
79
481
51
270
2.41
5.50
3.1
3.5
0.36
0.28
e6/l
0.21
39
194
32
135
2.78
5.49
3.4
2.9
13.46
14.15
umol/l
0.18
32
123
83
545
2.31
5.39
17.6
6.7
0.15
0.19
e9/l
2.32
77
479
18
55
3.61
5.24
4.5
5.4
—
—
—
0
0
54
300
2.31
5.17
3.3
3.5
48.22
284.42
e6/l
0.53
43
222
40
196
2.47
5.06
3.0
3.0
8.68
4.36
e6/l
0.71
40
171
48
264
2.25
4.63
3.2
3.4
—
—
—
0
0
48
274
2.15
4.16
1.7
1.4
—
—
—
0
0
7
7
10.45
4.05
2.4
3.4
—
—
—
0
0
36
191
2.20
3.70
3.1
3.2
566.78
571.23
mosm/kgh2o
0.04
36
151
14
46
3.27
3.64
9.1
2.3
21.00
20.56
s
0.21
14
41
8
13
6.46
3.55
6.3
5.0
7.33
8.15
kpa
—
8
13
8
13
6.46
3.55
6.3
5.0
5.20
4.93
kpa
—
8
13
55
350
1.95
3.45
4.4
4.0
28.65
88.08
e6/l
1.09
44
234
90
678
1.94
3.36
4.3
3.2
—
—
—
0
0
9
19
4.99
3.30
61.0
2.8
—
—
—
0
0
6
7
8.89
3.29
8.5
3.1
34.85
41.96
%
—
6
7
12
34
3.76
3.29
6.0
5.9
0.18
0.16
g/l
—
7
17
8
15
5.59
3.24
70.4
2.4
55.80
71.52
%
—
8
15
13
41
3.39
3.16
11.0
4.6
—
—
—
0
0
67
466
1.85
3.13
27.5
7.7
0.00
0.00
e9/l
0.50
56
368
5
5
10.30
3.00
108.6
2.6
8.76
13.36
%
—
5
5
15
61
2.64
2.72
8.0
8.2
—
—
—
0
0
19
88
2.34
2.65
7.1
6.6
5.15
4.90
kpa
0.97
19
82
6
11
5.64
2.57
1.2
1.2
—
—
—
0
0
5
7
7.35
2.57
2.2
1.7
—
—
—
0
0
7
16
4.55
2.51
2.9
4.8
—
—
—
0
0
53
364
1.74
2.45
4.2
3.5
16.31
41.28
ng/l
1.91
40
236
17
78
2.35
2.43
13.2
3.8
—
—
—
0
0
17
79
2.31
2.36
1.4
1.4
—
—
—
0
0
9
28
3.36
2.35
5.6
4.4
4.04
3.90
mmol/l
—
9
28
35
216
1.83
2.30
7.2
1.9
2.07
1.31
mg/l
0.57
30
163
5
9
5.71
2.23
1.0
1.0
—
—
—
0
0
96
789
1.71
2.19
4.6
3.5
15.14
14.71
pmol/l
0.81
88
720
125
1115
2.29
2.18
35.0
10.7
29.82
22.21
mg/l
1.53
111
821
5
10
5.14
2.09
1.2
1.0
—
—
—
0
0
6
15
4.13
2.06
1.7
1.0
—
—
—
0
0
17
84
2.17
2.06
5.0
3.8
—
—
—
0
0
8
26
3.20
2.05
1.4
1.2
—
—
—
0
0
5
11
4.67
1.96
2.2
1.8
—
—
—
0
0
6
16
3.87
1.95
3.8
3.2
56.67
55.94
%
—
6
16
6
16
3.87
1.95
3.0
3.2
3.89
4.09
e9/l
—
6
16
7
22
3.29
1.90
4.4
3.5
—
—
—
0
0
11
46
2.51
1.90
57.3
3.0
0.57
0.63
%
0.25
11
46
128
1167
2.34
1.86
40.2
11.8
78.58
76.44
umol/l
0.16
128
1167
15
74
2.15
1.83
7.2
3.2
—
—
—
0
0
11
47
2.46
1.83
57.3
3.0
1.27
1.15
%
0.37
11
47
84
704
1.49
1.47
6.0
4.2
—
—
—
0
0
5
16
3.20
1.45
1.2
1.4
0.12
0.76
nmol/l
—
5
11
23
144
1.72
1.43
1.5
1.5
—
—
—
0
0
6
23
2.68
1.38
2.2
1.8
—
—
—
0
0
6
25
2.46
1.25
1.3
1.3
—
—
—
0
0
126
1172
1.86
1.24
27.3
9.8
—
—
—
0
0
16
97
1.73
1.12
3.2
2.4
328.31
356.96
nmol/l
0.33
16
89
36
270
1.45
1.06
2.7
3.2
—
—
—
0
0
28
200
1.50
1.04
3.7
3.2
39.86
221.18
ng/l
2.27
23
145
10
53
1.96
1.04
6.0
3.5
5.03
5.03
pmol/l
—
10
46
10
53
1.96
1.04
1.1
1.3
—
—
—
0
0
43
335
1.41
1.03
3.4
3.3
7.32
8.05
mmol/l
0.40
36
296
6
116
0.50
0.99
1.5
1.7
—
—
—
0
0
108
987
1.43
0.95
5.2
4.1
2.12
1.86
mu/l
1.04
100
904
14
87
1.68
0.91
1.5
1.2
—
—
—
0
0
45
363
1.36
0.87
1.7
1.8
96.45
91.41
pmol/l
0.21
22
194
9
147
0.59
0.85
1.3
1.3
—
—
—
0
0
0
26
0.00
0.79
0.0
4.3
—
4.06
—
0
21
5
24
2.12
0.75
1.8
1.5
185.20
155.00
u/ml
—
5
11
58
495
1.30
0.74
6.0
3.6
0.00
0.00
estimate
-0.00
13
85
98
1054
0.76
0.71
4.4
3.9
1.42
1.43
mmol/l
0.14
91
984
30
235
1.35
0.69
5.2
3.8
—
—
—
0
0
30
235
1.35
0.69
5.2
3.7
—
—
—
0
0
101
1077
0.77
0.64
4.4
4.3
2.82
2.77
mmol/l
0.25
94
1010
26
202
1.35
0.63
1.6
1.6
—
—
—
0
0
94
1010
0.78
0.62
4.2
3.6
1.23
1.28
mmol/l
0.25
87
939
5
30
1.69
0.62
1.0
1.0
—
—
—
0
0
10
64
1.61
0.60
1.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.0
—
2.53
—
0
13
89
959
0.80
0.58
5.7
5.3
38.22
39.41
mmol/mol
0.64
82
906
6
36
1.70
0.57
1.0
1.1
—
—
—
0
0
100
1063
0.78
0.57
4.4
3.9
4.61
4.61
mmol/l
0.02
93
1000
33
396
0.78
0.56
2.6
2.7
—
—
—
0
0
32
265
1.27
0.51
7.7
3.7
0.00
0.00
estimate
-0.00
13
79
56
495
1.22
0.50
7.7
5.1
0.00
0.00
estimate
-0.00
13
77
12
163
0.71
0.47
1.3
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
193.79
—
0
15
5
34
1.49
0.41
1.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
7.70
—
0
9
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
79
0.62
0.36
1.2
1.2
—
192.63
—
0
28
6
47
1.29
0.32
2.0
2.2
—
—
—
0
0
20
166
1.24
0.32
1.4
1.8
385.50
432.90
pmol/l
0.44
14
147
130
1270
1.41
0.30
59.5
15.6
38.50
40.89
%
5.36
124
1195
55
505
1.15
0.30
6.2
3.6
0.00
0.00
estimate
-0.00
13
78
13
104
1.28
0.27
1.5
1.4
—
—
—
0
0
15
123
1.25
0.26
1.2
1.2
—
—
—
0
0
6
81
0.73
0.25
2.2
1.4
—
—
—
0
0
6
82
0.72
0.25
3.5
1.5
—
—
—
0
0
6
82
0.72
0.25
2.2
1.5
—
—
—
0
0
12
146
0.80
0.23
1.7
1.8
—
—
—
0
0
5
39
1.29
0.23
1.4
1.5
0.15
0.21
g/l
—
5
39
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
15
127
1.20
0.20
1.8
1.4
—
—
—
0
0
6
50
1.21
0.20
1.8
1.4
—
—
—
0
0
26
287
0.88
0.18
1.1
1.5
2.10
2.22
u/ml
—
6
69
5
70
0.70
0.17
9.0
2.3
—
—
—
0
0
6
78
0.76
0.16
2.2
1.4
—
—
—
0
0
6
80
0.74
0.16
2.2
1.4
—
—
—
0
0
30
276
1.11
0.15
3.0
3.2
241.18
67.33
mg/l
0.44
20
192
31
287
1.10
0.14
3.4
3.8
13.38
9.48
mg/mmol
0.17
20
194
28
260
1.10
0.12
1.8
1.4
2.29
2.15
g/l
0.23
18
155
5
63
0.79
0.08
2.4
1.5
—
—
—
0
0
7
65
1.08
0.08
1.3
1.3
—
—
—
0
0
9
84
1.08
0.07
2.0
3.0
3.19
6.46
ug/l
—
9
74
10
110
0.90
0.05
1.1
1.2
—
—
—
0
0
29
278
1.05
0.05
6.1
3.0
—
—
—
0
0
20
194
1.04
0.00
1.8
2.5
0.70
0.74
ug/l
0.07
14
116
26
263
0.99
0.00
1.5
1.9
—
—
—
0
0
101
1015
0.98
0.00
4.1
3.9
5.64
5.84
mmol/l
1.11
92
930
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.13
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.2
—
1.53
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
91.62
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.52
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_OSTEOSARCOMA_WIDE – Osteosarcoma, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).