info icon

This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Endocrine gland, other/unspecified

CD2_BENIGN_ENDOCRINE_NOS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D35.7&, D35.9&
  • Hospital discharge: ICD-9 227[8-9]
  • Hospital discharge: ICD-8 226[8-9]
  • Cause of death: ICD-10 D35.7&, D35.9&
  • Cause of death: ICD-9 227[8-9]
  • Cause of death: ICD-8 226[8-9]

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 119 86 33
Unadjusted period prevalence (%) 0.03 0.03 0.01
Median age at first event (years) 46.47 44.48 51.64

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1068
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
+∞
73.7
62
*
22680
ICD-8 Finland
Benign neoplasm of endocrine glands, Other specified endocrine glands
+∞
28.4
26
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
30.3
15.3
20
8
D35.7
ICD-10 Finland
Benign neoplasm: Other specified endocrine glands
+∞
13.8
13
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
53.1
12.2
14
*
JN4BD
NOMESCO Finland
Extensive body CT
14.2
10.3
17
14
101
Kela drug reimbursment
Anterior pituitary hypofunction
44.5
10.2
12
*
H02AB09
ATC
hydrocortisone; systemic
17.2
9.9
15
10
E23.00
ICD-10 Finland
Panhypopituitarism
60.6
9.8
11
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
60.6
9.8
11
*
D35.59
ICD-10 Finland
Other paragangliom
+∞
8.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
85.8
7.5
8
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.4
7
*
H02AB02
ATC
dexamethasone; systemic
32.4
7.3
9
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
74.1
6.5
7
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.3
6
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
6.3
6
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
6.3
6
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
6.3
6
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
6.3
38
158

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
25
8.85
13.99
1.4
1.1
—
—
—
0
0
11
13
9.22
8.60
1.9
1.2
—
—
nmol/l
—
0
0
10
14
7.71
6.81
2.2
1.2
—
—
—
0
0
19
55
3.92
6.02
1.8
2.0
0.2
0.2
g/l
0.21
19
48
8
6
14.16
5.15
3.4
1.0
4.3
5.9
nmol/l
—
8
6
54
310
2.36
4.92
2.4
1.6
—
—
—
0
0
26
114
2.64
4.15
3.6
2.0
0.8
0.8
mmol/l
1.50
26
107
7
8
9.20
3.82
1.6
1.3
—
—
—
0
0
6
7
8.94
3.30
3.2
1.1
—
—
—
0
0
42
252
2.03
3.18
1.9
1.9
—
—
—
0
0
21
100
2.34
2.79
1.4
1.3
—
—
—
0
0
37
224
1.95
2.67
8.0
4.0
—
—
—
0
0
5
8
6.46
2.39
3.0
1.4
—
—
—
0
0
68
521
1.71
2.15
11.8
5.6
3.9
4.1
e9/l
0.30
58
447
16
76
2.28
2.14
1.4
1.0
—
—
—
0
0
50
354
1.71
2.11
10.3
7.6
1.1
1.2
inr
0.36
15
107
22
122
1.99
2.01
1.7
2.7
2.4
2.3
g/l
0.12
17
112
12
53
2.41
1.87
1.3
1.4
—
—
—
0
0
7
24
3.03
1.75
1.3
1.2
—
—
—
0
0
10
44
2.39
1.58
4.0
6.7
91.7
94.4
%
—
10
44
16
87
1.97
1.55
1.4
1.5
—
—
—
0
0
7
27
2.69
1.54
4.6
1.8
—
—
—
0
0
10
46
2.28
1.44
4.0
6.3
1.5
1.6
%
—
10
46
22
137
1.74
1.42
1.3
1.4
506.7
492.6
titre
—
6
38
19
115
1.78
1.35
1.9
1.8
—
—
—
0
0
6
24
2.58
1.32
3.2
1.2
45.8
68.5
pmol/l
—
6
24
8
34
2.45
1.32
1.0
1.2
—
—
—
0
0
6
25
2.47
1.26
4.3
4.6
24.2
25.6
mmol/l
—
6
25
16
94
1.81
1.25
3.6
5.0
-0.0
1.3
mmol/l
0.92
11
75
5
19
2.70
1.23
1.0
1.2
—
—
—
0
0
78
672
1.47
1.15
4.7
4.2
—
—
—
0
0
49
388
1.45
1.13
3.9
3.7
27.9
32.9
ng/l
0.15
37
274
8
41
2.02
1.11
1.6
1.2
—
—
—
0
0
12
67
1.88
1.09
3.8
6.5
—
—
—
0
0
17
107
1.69
1.06
1.7
1.6
—
—
—
0
0
9
46
2.03
1.06
4.2
6.3
0.6
0.7
%
—
9
46
30
218
1.50
1.06
2.2
2.0
4.5
2.9
mg/l
0.69
25
183
28
202
1.50
1.02
1.6
1.3
2.6
2.6
g/l
0.03
19
108
30
220
1.49
1.01
3.4
3.1
—
—
—
0
0
58
482
1.40
1.00
7.0
5.0
1.7
1.9
e9/l
1.11
52
423
28
203
1.50
1.00
1.5
1.6
0.6
1.1
mg/l
1.10
17
158
57
473
1.39
0.99
6.6
4.8
0.6
0.6
e9/l
0.13
49
405
57
473
1.39
0.99
6.7
4.9
0.0
0.0
e9/l
0.14
49
406
27
196
1.49
0.95
4.5
4.6
—
—
—
0
0
20
136
1.57
0.94
28.3
21.4
—
1.2
—
0
25
26
189
1.48
0.91
3.4
2.3
7.5
5.7
e6/l
0.45
21
168
6
29
2.12
0.90
4.8
4.3
—
—
—
0
0
18
122
1.56
0.86
1.4
1.4
—
—
—
0
0
84
754
1.39
0.85
4.3
4.3
12.2
11.7
mm/h
0.10
76
689
37
292
1.39
0.84
4.0
2.0
2.4
2.4
mmol/l
0.18
31
246
39
311
1.38
0.83
6.8
4.7
—
—
—
0
0
58
493
1.34
0.83
7.0
4.8
0.2
0.2
e9/l
0.04
53
433
85
766
1.38
0.82
5.1
4.1
15.2
14.6
pmol/l
1.29
85
700
27
203
1.43
0.80
5.3
3.9
—
—
—
0
0
29
221
1.41
0.80
3.6
3.7
1.0
1.0
kg/l
—
5
41
15
99
1.59
0.80
1.7
2.1
27.7
5.7
umol/l
0.46
15
83
0
25
0.00
0.80
0.0
2.2
—
—
—
0
0
57
486
1.33
0.79
4.4
4.9
0.0
0.0
estimate
0.00
11
89
27
347
0.71
0.78
3.2
3.1
—
—
—
0
0
9
56
1.66
0.74
3.3
4.4
25.9
25.2
mmol/l
—
9
56
9
56
1.66
0.74
1.7
3.8
4.4
4.7
pmol/l
—
9
50
18
127
1.49
0.73
1.1
1.2
—
—
—
0
0
57
492
1.30
0.70
3.5
3.6
0.0
0.0
estimate
0.00
12
89
48
405
1.31
0.70
9.0
7.8
0.0
0.0
e9/l
0.00
40
319
56
483
1.30
0.69
3.7
3.6
0.0
0.0
estimate
—
10
90
7
43
1.67
0.68
1.0
1.1
—
—
—
0
0
32
258
1.33
0.63
4.5
3.6
0.0
0.0
estimate
0.00
12
89
0
21
0.00
0.60
0.0
2.1
—
130.2
—
0
12
94
994
0.74
0.59
5.3
5.3
2.6
2.8
mmol/l
1.16
88
917
26
206
1.34
0.57
3.1
3.5
17.2
97.0
ng/l
0.78
21
158
12
82
1.52
0.57
1.4
1.4
—
—
—
0
0
44
376
1.27
0.56
3.2
3.2
—
—
—
0
0
6
96
0.61
0.55
2.0
1.8
—
—
—
0
0
92
970
0.77
0.49
4.5
4.7
1.5
1.5
mmol/l
0.25
87
895
97
918
1.31
0.48
5.6
4.9
1.8
3.2
mu/l
0.53
89
836
5
33
1.54
0.42
4.8
4.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
0.9
—
0
9
0
16
0.00
0.41
0.0
2.4
—
63.2
—
0
16
74
686
1.21
0.41
4.4
3.7
—
—
—
0
0
0
17
0.00
0.41
0.0
3.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
1.8
—
0
10
8
61
1.33
0.40
1.9
1.7
—
—
—
0
0
9
66
1.39
0.39
1.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
2.7
—
—
—
0
0
33
286
1.21
0.36
3.6
3.1
—
—
—
0
0
27
229
1.23
0.36
1.5
1.3
—
—
—
0
0
7
51
1.40
0.32
5.4
3.5
4.7
5.2
kpa
—
7
46
32
286
1.16
0.25
1.5
1.7
1.3
1.3
mmol/l
0.20
27
243
29
325
0.86
0.25
3.2
3.8
1.0
7.4
mg/mmol
3.00
17
191
23
200
1.19
0.24
1.7
1.8
475.5
461.6
pmol/l
0.07
18
161
28
314
0.86
0.24
3.6
3.0
7.3
49.9
mg/l
2.68
13
190
90
930
0.87
0.22
5.6
5.9
38.9
39.8
mmol/mol
0.55
85
868
5
42
1.20
0.22
2.0
14.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.26
0.20
4.7
3.6
—
7.4
—
0
7
6
49
1.24
0.20
1.0
1.7
—
—
—
0
0
6
51
1.19
0.19
3.8
3.9
—
—
—
0
0
30
328
0.89
0.18
2.8
2.9
5.9
7.6
mmol/l
1.71
25
273
37
342
1.12
0.18
5.9
3.6
93.4
134.2
e6/l
0.19
25
231
17
193
0.86
0.17
1.2
1.3
4.1
14.2
u/ml
—
6
69
100
977
1.15
0.16
18.6
11.4
17.0
20.5
mg/l
0.69
82
735
6
75
0.79
0.16
1.0
2.8
—
—
—
0
0
91
934
0.89
0.16
4.1
4.2
1.3
1.3
mmol/l
0.20
85
853
31
286
1.11
0.15
5.6
3.0
72.6
27.2
e6/l
0.39
23
211
28
257
1.12
0.15
5.4
2.8
—
—
—
0
0
30
277
1.11
0.14
3.0
3.4
—
—
—
0
0
12
105
1.16
0.11
2.4
1.5
—
—
—
0
0
104
1023
1.13
0.11
14.9
10.6
—
—
—
0
0
10
88
1.15
0.08
3.8
3.6
—
—
—
0
0
95
965
0.92
0.08
5.0
4.6
5.7
6.0
mmol/l
2.13
86
885
7
67
1.05
0.08
4.7
1.3
—
—
—
0
0
7
68
1.03
0.08
3.6
2.2
—
—
—
0
0
6
71
0.84
0.08
4.7
3.0
1.2
1.2
mmol/l
—
6
59
6
72
0.82
0.08
1.8
1.4
—
—
—
0
0
6
74
0.80
0.08
2.0
3.8
—
—
—
0
0
8
93
0.85
0.07
2.8
2.6
2.1
1.6
%
—
8
84
14
130
1.09
0.05
2.2
1.8
—
—
—
0
0
30
290
1.05
0.03
4.2
3.7
—
—
—
0
0
104
1032
1.06
0.02
20.7
13.6
72.7
75.9
umol/l
0.83
104
1032
27
263
1.03
0.01
5.9
3.0
1.8
0.4
e6/l
0.40
20
188
20
194
1.04
0.00
1.2
1.3
14.6
43.2
iu/ml
—
6
64
87
875
0.98
0.00
17.8
12.7
39.8
39.9
%
0.01
63
629
43
425
1.02
0.00
2.3
1.9
103.0
97.7
pmol/l
0.35
30
202
25
251
0.99
0.00
3.0
2.2
23955.3
3383.0
umol/l
0.40
18
213
0
5
0.00
0.00
0.0
1.0
—
124.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
28.3
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
—
—
0
0
6
62
0.97
0.00
2.2
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
11.3
—
0
7
8
79
1.01
0.00
1.3
1.4
—
—
—
0
0
9
90
1.00
0.00
2.8
3.8
2.7
2.2
mmol/l
—
9
73
0
7
0.00
0.00
0.0
1.7
—
14.0
—
0
7
9
97
0.92
0.00
2.8
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
78
0.89
0.00
1.1
1.4
—
—
—
0
0
8
82
0.97
0.00
1.5
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_ENDOCRINE_NOS_EXALLC – Benign neoplasm: Endocrine gland, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).