Benign neoplasm: Other specified/unspecified intrathoracic organs (+ respiratory system NOS of Icd-9)

CD2_BENIGN_INTRATHORACIC_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D15.7&, D15.9&
  • Hospital discharge: ICD-9 212[8-9]|2124
  • Hospital discharge: ICD-8 2124
  • Cause of death: ICD-10 D15.7&, D15.9&
  • Cause of death: ICD-9 212[8-9]|2124
  • Cause of death: ICD-8 2124

2 out of 7 registries used, show all original rules.

93

4. Check minimum number of events

None

93

5. Include endpoints

None

93

6. Filter based on genotype QC (FinnGen only)

93

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Similar endpoints

List of similar endpoints to Benign neoplasm: Other specified/unspecified intrathoracic organs (+ respiratory system NOS of Icd-9) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 643 324 311
Only index persons 503 282 221
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.15 54.00 51.91
Only index persons 50.65 52.73 48.01

-FinnGen-

Key figures

All Female Male
Number of individuals 93 45 48
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 53.42 53.98 52.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
87
Matched controls
871
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D15.9
ICD-10 Finland
Benign neoplasm: Intrathoracic organ, unspecified
+∞
43.4
38
*
D15.7
ICD-10 Finland
Benign neoplasm: Other specified intrathoracic organs
+∞
37.2
33
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.4
9.4
26
54
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
8.5
8
*
2129X
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Site unspecified
+∞
6.3
6
*
D15.1
ICD-10 Finland
Benign neoplasm: Heart
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
6
5
12.69
3.81
2.5
1.6
37.8
25.2
g/l
—
6
5
40
232
2.27
3.56
2.2
2.3
—
—
—
0
0
5
5
10.46
3.01
2.8
1.6
—
—
—
0
0
5
6
8.71
2.78
2.2
2.3
—
—
—
0
0
12
43
3.06
2.76
2.3
2.6
4.1
3.8
e9/l
0.24
12
32
45
298
1.99
2.67
11.1
8.4
1.2
1.3
inr
0.15
16
86
9
30
3.21
2.21
1.1
1.2
—
—
—
0
0
9
31
3.10
2.14
2.2
5.3
—
—
—
0
0
43
298
1.82
2.10
2.2
1.9
—
—
—
0
0
17
85
2.22
2.06
5.8
7.0
1.1
1.0
mmol/l
1.31
17
79
12
53
2.45
1.90
1.7
3.3
66.0
66.8
g/l
0.14
12
46
43
312
1.70
1.71
13.6
8.8
0.0
0.0
e9/l
0.66
38
258
27
173
1.79
1.65
7.3
7.7
—
—
—
0
0
15
80
2.04
1.55
1.1
1.3
—
—
—
0
0
9
37
2.58
1.53
6.0
3.8
25.6
24.6
mmol/l
—
9
37
34
238
1.68
1.51
4.8
5.4
—
—
—
0
0
17
98
1.90
1.43
2.1
1.6
—
—
—
0
0
13
68
2.06
1.41
1.4
1.5
—
—
—
0
0
9
44
2.16
1.31
1.2
1.4
—
—
—
0
0
14
78
1.94
1.29
4.6
4.2
2.4
93.8
ug/l
0.53
14
65
46
361
1.54
1.23
5.8
5.6
1.7
1.8
e9/l
0.24
41
323
47
371
1.54
1.22
5.6
6.1
0.2
0.2
e9/l
0.29
41
330
6
26
2.40
1.20
1.2
1.2
—
—
—
0
0
45
357
1.50
1.12
5.6
5.5
0.0
0.0
e9/l
0.23
39
314
45
357
1.50
1.12
5.6
5.5
0.6
0.6
e9/l
0.10
39
314
17
109
1.68
1.02
1.9
1.6
—
—
—
0
0
59
502
1.48
0.99
4.9
4.0
—
—
—
0
0
11
62
1.88
0.99
1.5
1.3
—
—
—
0
0
11
63
1.85
0.95
3.6
5.1
—
—
—
0
0
19
130
1.58
0.90
2.1
1.7
1282.1
1243.5
nmol/l
0.07
14
100
27
203
1.47
0.84
3.9
4.1
—
—
—
0
0
14
90
1.65
0.84
1.2
1.2
—
—
—
0
0
27
209
1.41
0.72
6.0
3.6
7.4
7.4
ph
—
7
38
27
209
1.41
0.72
1.9
2.1
162.5
199.4
u/l
0.30
27
200
36
293
1.37
0.71
4.8
4.1
16.9
56.1
ng/l
1.65
24
207
7
43
1.68
0.68
1.9
1.2
282.0
153.0
u/ml
—
7
36
21
159
1.41
0.62
5.0
5.0
—
—
—
0
0
8
51
1.62
0.62
4.3
2.6
132.6
133.5
ng/l
—
8
45
8
52
1.59
0.61
9.4
3.4
1.2
1.2
mmol/l
—
8
45
0
20
0.00
0.61
0.0
6.3
—
32.5
—
0
14
72
766
0.73
0.53
20.8
13.5
—
—
—
0
0
78
817
0.72
0.46
29.0
20.6
4.4
4.5
e12/l
0.96
78
790
78
817
0.72
0.46
29.1
20.5
6.8
6.7
e9/l
0.22
78
792
78
816
0.73
0.44
28.9
20.5
90.3
90.9
fl
0.70
78
804
78
816
0.73
0.44
28.8
20.5
29.8
30.3
pg
1.57
78
804
8
57
1.44
0.43
7.1
3.4
—
—
—
0
0
78
815
0.73
0.42
29.1
20.6
251.0
248.2
e9/l
0.15
78
791
0
15
0.00
0.41
0.0
1.8
—
3.4
—
0
6
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
0.2
—
0
18
0
18
0.00
0.40
0.0
2.8
—
—
—
0
0
12
89
1.40
0.40
1.8
2.1
126.6
153.5
ug/g
—
7
73
67
711
0.79
0.39
4.6
4.4
1.4
1.5
mmol/l
0.16
60
645
24
201
1.26
0.37
5.4
4.0
0.0
0.0
estimate
—
10
66
26
220
1.25
0.37
3.5
3.2
—
—
—
0
0
21
174
1.27
0.35
1.4
1.3
—
—
—
0
0
10
74
1.39
0.34
1.9
1.6
—
—
—
0
0
67
706
0.82
0.32
4.8
4.7
5.8
6.0
mmol/l
0.51
61
646
7
54
1.32
0.31
1.3
1.9
—
—
—
0
0
7
54
1.32
0.31
3.0
2.7
9.4
9.7
g/l
—
7
47
25
215
1.22
0.31
5.3
4.1
—
—
—
0
0
11
87
1.30
0.25
1.7
1.5
—
—
—
0
0
66
691
0.85
0.25
4.0
4.0
1.2
1.3
mmol/l
0.20
61
627
38
347
1.16
0.24
6.2
5.4
0.0
0.0
estimate
0.00
12
66
22
192
1.19
0.23
3.8
3.1
23.2
47.5
mg/l
0.80
13
116
5
41
1.23
0.22
1.4
1.6
—
—
—
0
0
5
42
1.20
0.22
2.4
2.3
—
—
—
0
0
5
42
1.20
0.22
4.6
4.6
1.0
1.5
%
—
5
42
5
42
1.20
0.22
4.6
5.3
0.7
0.7
%
—
5
42
0
11
0.00
0.21
0.0
4.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
70.4
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
53.0
—
0
5
31
281
1.15
0.21
1.8
1.9
88.6
91.9
pmol/l
0.15
14
133
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
23
204
1.17
0.20
5.4
3.8
1.8
5.8
mg/mmol
1.55
15
126
38
351
1.14
0.20
4.8
4.0
0.0
0.0
estimate
0.00
11
65
6
51
1.19
0.20
1.3
2.9
—
—
—
0
0
45
421
1.13
0.19
8.9
9.8
4.1
4.0
e9/l
0.11
40
364
23
205
1.16
0.19
4.0
3.6
—
—
—
0
0
77
747
1.18
0.18
21.3
16.1
139.9
139.7
mmol/l
0.24
77
728
13
111
1.20
0.17
1.2
1.4
34.2
19.8
u/ml
—
5
44
69
713
0.88
0.17
4.7
4.5
4.5
4.6
mmol/l
0.16
62
654
77
749
1.16
0.16
21.5
16.2
3.9
4.0
mmol/l
0.66
77
730
27
248
1.13
0.15
2.5
2.2
56.5
56.6
u/l
0.01
20
231
63
607
1.12
0.15
21.6
17.0
14.1
13.7
%
0.73
63
597
12
103
1.19
0.14
1.3
1.2
—
—
—
0
0
11
94
1.19
0.14
1.3
1.4
—
—
—
0
0
17
153
1.14
0.12
1.1
1.3
0.8
1.1
u/ml
—
8
42
48
500
0.92
0.11
4.9
4.0
—
—
—
0
0
16
144
1.13
0.11
2.8
2.9
2.5
2.5
mmol/l
0.51
16
124
27
252
1.10
0.11
2.7
3.0
—
—
—
0
0
37
351
1.09
0.11
4.9
3.9
0.0
0.0
estimate
0.00
12
69
48
461
1.09
0.10
4.8
4.2
—
45.7
—
0
10
6
58
1.04
0.08
4.3
5.3
—
—
—
0
0
6
73
0.81
0.08
1.5
1.2
—
—
—
0
0
10
89
1.14
0.07
3.8
3.2
1.7
1.7
%
—
10
80
26
273
0.93
0.06
4.3
3.8
—
—
—
0
0
72
732
0.93
0.06
5.0
5.0
2.6
2.7
mmol/l
0.41
63
667
29
278
1.06
0.05
3.3
3.4
520.7
74.6
e6/l
0.65
24
198
21
199
1.07
0.05
3.0
2.6
—
—
—
0
0
13
123
1.07
0.02
1.2
1.3
115.2
35.9
iu/ml
—
5
46
67
676
0.97
0.00
5.8
5.9
38.6
40.0
mmol/mol
0.67
60
633
66
654
1.03
0.00
13.7
15.0
39.6
40.5
%
0.69
43
480
11
108
1.02
0.00
4.6
2.6
18.4
21.5
%
0.66
11
90
16
163
0.98
0.00
5.5
3.7
—
—
—
0
0
73
733
0.98
0.00
19.9
14.3
15.3
23.4
mg/l
3.10
64
579
14
144
0.97
0.00
1.5
1.4
2.1
2.4
g/l
—
8
82
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
7
72
0.97
0.00
1.9
2.0
299.6
370.1
nmol/l
—
7
65
5
54
0.92
0.00
7.4
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
1.2
—
0
5
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
5
57
0.87
0.00
6.2
3.7
—
—
—
0
0
8
81
0.99
0.00
1.5
1.6
—
—
—
0
0
6
59
1.02
0.00
1.3
4.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
78
780
1.00
0.00
21.9
16.4
82.9
77.5
umol/l
0.35
78
780
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
0.2
—
0
6
5
49
1.02
0.00
2.2
1.6
0.9
1.1
g/l
—
5
42
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
9
96
0.93
0.00
1.6
1.3
—
475.0
—
0
24
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_INTRATHORACIC_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_INTRATHORACIC_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_INTRATHORACIC_NOS – Benign neoplasm: Other specified/unspecified intrathoracic organs (+ respiratory system NOS of Icd-9)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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