testicular carcinoma: A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly males |
226754 |
2. Check conditionsNone |
226754 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
161 |
4. Check minimum number of eventsNone |
161 |
5. Include endpointsNone |
161 |
6. Filter based on genotype QC (FinnGen only) |
154 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D29
- Name in latin
- Neoplasma benignum testis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Testis
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of male genital organs
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1309 | - | 1309 |
| Only index persons | 1140 | - | 1140 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | - | 0.04 |
| Only index persons | 0.04 | - | 0.04 |
| Median age at first event (years) | |||
| Whole population | - | - | 39.28 |
| Only index persons | - | - | 36.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 154 | - | 154 |
| Unadjusted period prevalence (%) | 0.07 | - | 0.07 |
| Median age at first event (years) | 47.36 | - | 47.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 161
- Matched controls
- 1610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D29.2
ICD-10 Finland
Benign neoplasm: Testis
+∞
149.0
119
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
72.1
89.3
50
10
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
99.8
41.4
44
6
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
11.3
28.4
33
36
22200
ICD-8 Finland
Benign neoplasm of male genital organs, Testis
+∞
27.9
26
*
2220A
ICD-9 Finland
Benign neoplasm of male genital organs, Testis
+∞
17.0
16
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
+∞
13.7
13
*
KFA00
NOMESCO Finland
Exploration of testis
31.4
13.3
17
6
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
12.7
12
*
7501
FHL
Testicular exploration (includes removal of biopsy, detorsion or appendix test)
106.0
9.5
10
*
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
83.8
7.5
8
*
JN4BD
NOMESCO Finland
Extensive body CT
3.3
6.6
27
92
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
6
27.34
11.36
3.8
4.3
—
—
—
0
0
44
183
2.93
7.80
2.8
2.3
12.07
13.73
nmol/l
0.62
39
166
10
28
3.74
2.84
1.2
1.6
1.96
2.99
mg/l
—
10
21
82
623
1.64
2.48
13.7
15.9
1.24
1.39
inr
0.91
27
166
102
827
1.64
2.32
5.1
5.0
3.57
2.83
ug/l
0.16
90
737
18
89
2.15
2.15
1.6
1.8
—
—
—
0
0
23
128
1.93
2.03
4.3
3.3
—
—
—
0
0
69
524
1.55
1.97
2.7
2.9
—
—
—
0
0
62
460
1.57
1.96
3.8
3.3
—
—
—
0
0
16
80
2.11
1.87
4.5
2.7
63.33
60.97
ml/min/173m2
—
6
33
19
102
1.98
1.85
2.0
1.8
—
—
—
0
0
36
241
1.64
1.72
3.1
3.7
225.49
174.38
ng/l
0.11
29
196
0
49
0.00
1.71
0.0
1.1
—
83.26
—
0
12
6
19
3.24
1.67
1.0
1.3
—
—
—
0
0
14
70
2.10
1.65
12.2
8.8
24.78
24.38
mmol/l
0.13
14
70
49
358
1.53
1.62
3.8
3.1
0.74
0.44
e6/l
0.28
38
276
7
28
2.57
1.47
1.0
1.4
—
—
—
0
0
7
28
2.57
1.47
1.0
1.4
—
—
—
0
0
6
24
2.56
1.31
1.0
1.1
—
—
—
0
0
5
18
2.83
1.29
2.0
1.3
105.04
199.62
pmol/l
—
5
18
8
39
2.11
1.17
1.8
1.4
—
—
—
0
0
8
40
2.05
1.14
1.1
1.5
—
—
—
0
0
5
22
2.31
1.04
2.8
2.2
—
—
—
0
0
40
310
1.39
0.96
4.6
3.9
0.00
0.04
estimate
0.68
16
95
53
435
1.33
0.88
1.8
1.9
86.72
89.29
pmol/l
0.12
25
247
6
30
2.04
0.88
9.3
6.3
—
377.80
—
0
5
128
1190
1.37
0.84
17.0
15.9
31.92
26.16
mg/l
0.78
105
962
52
431
1.31
0.80
2.6
2.5
178.31
192.55
ug/l
0.14
47
398
29
220
1.39
0.79
1.9
1.9
31.43
29.71
s
0.74
29
214
31
239
1.37
0.77
1.6
1.7
1.64
1.53
mg/l
0.06
25
189
65
559
1.27
0.75
10.0
8.7
1.20
1.20
mmol/l
0.13
54
481
75
661
1.25
0.69
4.5
4.4
20.68
21.86
%
0.28
34
324
21
154
1.42
0.69
1.3
1.9
—
—
—
0
0
55
470
1.26
0.66
3.1
3.0
0.68
0.84
ug/l
0.66
36
303
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
23
178
1.34
0.57
7.6
8.3
105.74
103.84
mmol/l
1.05
23
178
33
391
0.80
0.48
3.9
4.1
6.34
10.34
mg/mmol
0.47
23
280
7
47
1.51
0.48
1.9
2.8
—
—
—
0
0
75
681
1.19
0.48
10.6
10.2
4.33
4.40
e9/l
0.10
69
590
5
32
1.58
0.42
1.0
1.4
—
—
—
0
0
16
123
1.33
0.42
2.6
4.0
1.65
1.58
mmol/l
0.04
11
92
91
847
1.17
0.41
4.3
4.0
10.74
11.88
mm/h
0.37
86
779
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
4.2
—
51.20
—
0
5
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
105
997
1.15
0.34
3.5
3.6
1.81
2.04
mu/l
1.53
95
888
19
156
1.25
0.33
1.4
2.0
—
—
—
0
0
8
106
0.74
0.30
1.4
1.8
—
—
—
0
0
8
62
1.31
0.28
2.4
2.4
1.84
3.07
ug/l
—
8
55
9
118
0.75
0.28
2.1
2.3
6.90
8.94
ug/l
—
9
104
11
139
0.78
0.28
7.5
9.0
—
—
—
0
0
11
88
1.27
0.23
3.4
2.3
301.36
233.78
ng/l
0.16
11
77
10
79
1.28
0.23
1.1
1.8
—
—
—
0
0
24
211
1.16
0.22
4.5
2.9
0.23
0.44
e6/l
0.75
13
118
0
11
0.00
0.21
0.0
1.8
—
3.67
—
0
6
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
58
543
1.11
0.21
5.3
4.7
0.00
0.00
estimate
-0.00
16
104
31
280
1.13
0.20
3.2
2.7
—
—
—
0
0
19
165
1.17
0.20
1.1
1.2
142.52
25.97
iu/ml
—
5
44
49
524
0.91
0.19
3.5
3.8
48.58
46.82
ng/l
0.03
36
382
114
1107
1.10
0.18
5.3
6.3
40.50
40.96
mmol/mol
0.19
106
1031
47
439
1.10
0.18
4.4
3.7
—
—
—
0
0
58
548
1.09
0.17
4.3
3.5
0.00
0.01
estimate
0.50
16
111
18
158
1.16
0.17
1.3
1.4
—
—
—
0
0
136
1337
1.11
0.14
26.5
22.9
42.02
45.07
%
0.40
127
1250
114
1113
1.08
0.14
18.0
14.8
82.66
81.66
ml/min/173m2
0.17
100
922
25
229
1.11
0.13
1.8
1.7
1332.83
1182.26
nmol/l
0.15
18
174
121
1186
1.08
0.12
4.0
4.5
4.48
4.43
mmol/l
0.23
112
1098
28
259
1.10
0.12
1.7
1.8
423.00
400.01
pmol/l
0.21
22
225
58
555
1.07
0.12
4.3
3.5
0.00
0.00
estimate
-0.00
14
94
24
223
1.09
0.10
3.9
2.7
0.46
1.11
e6/l
0.97
13
128
6
73
0.82
0.08
7.5
5.2
62.48
92.20
ng/l
—
6
67
120
1184
1.05
0.07
4.0
4.4
1.33
1.30
mmol/l
0.53
111
1085
8
92
0.86
0.07
5.0
3.6
1.18
1.56
mmol/l
—
8
67
74
723
1.04
0.06
2.9
2.9
—
—
—
0
0
79
775
1.04
0.05
2.8
2.9
15.33
14.82
pmol/l
1.06
73
678
129
1278
1.05
0.04
11.6
10.7
27.74
30.74
u/l
1.41
129
1232
113
1142
0.96
0.04
4.5
4.7
6.09
6.14
mmol/l
0.15
106
1029
11
102
1.08
0.03
1.7
1.5
—
—
—
0
0
115
1160
0.97
0.03
3.5
4.0
1.30
1.36
mmol/l
0.34
104
1059
121
1212
0.99
0.00
4.5
4.9
2.68
2.68
mmol/l
0.00
113
1113
22
215
1.03
0.00
2.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
38.20
—
0
5
5
50
1.00
-0.00
6.2
3.5
—
1.34
—
0
6
5
53
0.94
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
2.1
2.5
1.10
1.36
%
—
7
70
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.90
-0.00
1.6
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_TESTIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_TESTIS | 1.218 [0.97, 1.53] | 0.089 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 807 males with CD2_BENIGN_TESTIS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_TESTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.273% |
| 5 | No data | 1.509% |
| 10 | No data | 3.655% |
| 15 | No data | 6.935% |
| 20 | No data | 11.538% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_TESTIS – Benign neoplasm: Testis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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