This is a non-core endpoint: only basic statistics are computed.
Carcinoma in situ of prostate
CD2_INSITU_PROSTATE
Grade III Prostatic Intraepithelial Neoplasia: High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly males |
226754 |
2. Check conditions
|
206128 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D07
- Name in latin
- Carcinoma in situ oculi
Carcinoma in situ of prostate
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | - | 196 |
| Unadjusted period prevalence (%) | 0.09 | - | 0.09 |
| Median age at first event (years) | 68.07 | - | 68.07 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8148/2-C61.9
ICD-O-3
Glandular intraepithelial neoplasia, high grade of prostate gland
4976.5
222.8
173
*
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
11.7
70.6
108
180
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
11.0
64.0
94
147
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
15.2
58.0
58
52
XKD00
NOMESCO Finland
Uroflowmetry
6.3
37.8
125
414
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.4
32.4
111
369
N40
ICD-10 Finland
Hyperplasia of prostate
6.5
31.1
159
726
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
5.0
27.0
83
246
8140/2-C61.9
ICD-O-3
Adenocarcinoma in situ, NOS, of prostate gland
+∞
26.6
25
*
TKE00
NOMESCO Finland
Needle biopsy of prostate
6.5
24.0
45
85
KEB00
NOMESCO Finland
Biopsy of prostate
15.3
17.1
28
21
C61
ICD-10 Finland
Malignant neoplasm of prostate
3.2
12.5
66
267
KE1DG
NOMESCO Finland
Very extensive MRI of prostate
9.9
12.1
24
27
XJH00
NOMESCO Finland
Transanal ultrasonography
3.7
11.4
41
129
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
4.7
9.9
24
56
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
10.3
9.5
18
19
G04CA52
ATC
tamsulosin and dutasteride; systemic
2.6
8.9
66
314
R33
ICD-10 Finland
Retention of urine
3.1
8.7
41
152
KDE20
NOMESCO Finland
Removal of foreign body from urethra
10.7
8.2
15
15
G04CB02
ATC
dutasteride; oral
2.7
8.1
52
229
G04CA02
ATC
tamsulosin; oral
2.3
7.8
119
772
R39.1
ICD-10 Finland
Other difficulties with micturition
4.5
7.5
19
46
G04CB01
ATC
finasteride; oral
2.4
6.7
60
307
KED22
NOMESCO Finland
Transurethral resection of prostate
2.9
6.3
33
129
ZXC96
NOMESCO Finland
Robot assisted procedure
4.3
6.0
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
160
840
5.27
23.50
6.4
3.1
0.95
0.75
ug/l
3.01
147
581
121
587
3.63
18.18
4.9
3.3
261.62
150.57
e6/l
0.17
106
469
132
706
3.49
16.39
4.9
3.3
—
—
—
0
0
178
1175
5.18
15.66
8.3
4.4
15.76
21.37
%
14.16
153
588
110
540
3.26
15.51
4.6
3.2
0.09
0.53
e6/l
3.11
97
421
116
622
3.02
13.45
4.7
3.7
—
—
—
0
0
192
1460
6.81
11.38
10.3
5.1
6.13
2.41
ug/l
18.75
186
1309
131
796
2.82
11.30
5.9
4.7
0.00
0.00
estimate
-0.00
44
151
131
798
2.81
11.21
4.5
3.5
0.04
0.01
estimate
0.39
48
158
132
809
2.81
11.13
4.5
3.5
0.00
0.00
estimate
-0.00
44
138
72
332
2.81
10.53
4.4
3.0
0.30
0.53
e6/l
1.60
52
199
69
347
2.50
8.18
3.6
2.8
0.66
0.86
e6/l
0.54
49
211
82
447
2.40
8.14
4.8
3.6
0.00
0.02
estimate
0.50
43
135
192
1617
4.46
6.41
18.2
15.6
74.86
76.85
ml/min/173m2
0.77
179
1376
45
212
2.44
5.96
4.8
3.0
—
—
—
0
0
194
1722
3.85
5.37
5.6
5.5
2.54
2.54
mmol/l
0.00
179
1577
14
36
4.10
4.08
3.8
3.0
18.26
16.18
%
—
9
22
189
1675
2.86
3.80
5.0
5.2
6.13
6.23
mmol/l
0.60
176
1519
186
1636
2.63
3.79
4.6
4.4
1.30
1.33
mmol/l
0.22
171
1491
195
1794
3.21
3.47
20.4
20.4
139.44
139.58
mmol/l
0.31
195
1757
195
1800
3.11
3.32
20.4
20.5
4.03
4.04
mmol/l
0.28
195
1765
188
1682
2.59
3.32
5.2
5.0
4.30
4.30
mmol/l
0.00
173
1553
187
1671
2.51
3.27
5.1
4.9
1.30
1.30
mmol/l
0.06
172
1527
181
1625
2.05
2.65
6.9
6.8
40.69
41.25
mmol/mol
0.42
171
1513
106
832
1.57
2.59
2.4
2.8
—
—
—
0
0
184
1668
2.10
2.51
16.6
16.9
26.58
27.17
mg/l
0.07
163
1380
10
34
3.04
2.31
1.4
3.4
105.10
104.65
mmol/l
—
10
34
9
29
3.20
2.25
5.9
3.2
61.11
55.79
%
—
9
29
130
1113
1.47
1.84
4.5
5.6
6.98
6.95
mmol/l
0.06
121
1066
8
30
2.73
1.74
1.4
1.4
—
—
—
0
0
7
28
2.55
1.46
1.7
1.5
—
—
—
0
0
25
159
1.65
1.43
3.2
3.2
4.33
4.53
kpa
0.23
25
151
159
1457
1.42
1.25
3.8
3.8
2.00
2.05
mu/l
0.21
148
1295
16
259
0.59
1.24
7.9
9.1
12.18
11.76
kpa
0.17
16
250
16
259
0.59
1.24
7.9
9.1
5.28
5.00
kpa
0.70
16
249
28
192
1.53
1.19
4.5
4.2
5.91
5.68
kpa
0.61
28
184
125
1107
1.34
1.19
3.0
3.0
14.95
14.93
pmol/l
0.04
110
966
5
21
2.41
1.09
3.0
2.5
—
—
—
0
0
5
21
2.41
1.09
1.0
1.3
259.60
158.27
pmol/l
—
5
21
7
33
2.16
1.06
1.0
1.1
—
—
—
0
0
139
1261
1.32
1.06
4.0
4.1
10.32
12.82
mm/h
1.24
130
1167
87
742
1.30
1.05
1.6
2.0
87.31
90.60
pmol/l
0.30
44
446
5
23
2.20
0.98
1.4
1.3
—
—
—
0
0
36
273
1.39
0.94
5.7
6.9
0.95
1.02
mmol/l
1.01
36
259
16
102
1.62
0.93
2.3
2.6
0.69
0.66
%
0.25
16
102
110
978
1.27
0.93
17.3
16.2
1.33
1.35
inr
0.08
44
272
14
87
1.65
0.90
2.1
1.8
44.50
43.74
nmol/l
0.06
14
82
41
323
1.34
0.85
4.3
3.4
2.44
2.45
mmol/l
0.25
35
287
16
105
1.57
0.84
2.3
2.7
0.93
1.22
%
1.16
16
105
63
529
1.28
0.83
2.6
3.1
14854.67
8024.44
umol/l
0.29
55
464
70
598
1.26
0.80
1.8
2.8
56.22
66.62
u/l
0.70
65
565
0
25
0.00
0.79
0.0
1.0
—
21.50
—
0
6
13
83
1.61
0.77
1.2
1.1
176.66
159.15
u/ml
0.10
13
71
107
967
1.23
0.72
7.7
9.7
4.24
4.35
e9/l
0.18
89
844
44
360
1.28
0.71
1.5
1.6
1.69
1.69
mg/l
0.00
33
286
16
225
0.69
0.70
7.9
10.0
123.94
122.77
g/l
0.11
16
219
21
154
1.41
0.68
2.3
2.1
461.76
364.86
nmol/l
0.84
21
140
75
657
1.22
0.67
4.1
4.1
6.95
9.54
mg/mmol
0.39
55
458
8
131
0.59
0.66
1.9
1.7
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
6
36
1.69
0.57
2.7
2.3
—
—
—
0
0
6
36
1.69
0.57
1.3
1.4
—
—
—
0
0
103
944
1.18
0.55
5.4
7.8
12.30
13.42
umol/l
0.78
98
907
54
468
1.21
0.53
1.6
1.7
1.54
1.40
mmol/l
0.60
40
385
9
64
1.42
0.52
1.8
1.5
—
—
—
0
0
62
546
1.20
0.52
2.3
2.2
156.93
393.74
u/l
1.05
57
510
72
644
1.18
0.51
2.4
2.6
205.91
218.81
ug/l
0.14
64
589
87
793
1.17
0.48
4.4
4.0
40.13
49.33
ng/l
0.33
68
630
19
148
1.31
0.45
1.1
1.2
—
—
—
0
0
64
572
1.17
0.45
2.0
2.2
81.45
74.57
nmol/l
1.19
57
502
31
368
0.81
0.44
5.3
4.1
593.88
389.40
ng/l
0.21
26
313
18
140
1.31
0.43
1.9
2.6
63.75
61.45
ml/min/173m2
—
8
64
5
31
1.63
0.43
1.0
1.4
2.20
3941.00
e6/l
—
5
24
18
227
0.77
0.43
9.3
8.3
—
—
—
0
0
0
15
0.00
0.41
0.0
3.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
40
458
0.84
0.40
2.4
2.6
—
—
—
0
0
0
18
0.00
0.40
0.0
2.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
2.60
—
0
7
6
42
1.44
0.36
4.2
3.9
13.00
28.50
mg/l
—
6
29
86
799
1.13
0.35
2.4
2.3
—
—
—
0
0
17
209
0.80
0.34
5.1
4.7
11.40
26.64
ug/l
0.33
12
174
10
131
0.75
0.32
2.0
1.7
—
—
—
0
0
39
346
1.16
0.31
1.5
2.0
32.08
29.53
s
1.94
39
335
7
55
1.28
0.30
1.0
1.0
—
—
—
0
0
69
642
1.11
0.27
2.7
3.2
1504.31
1333.72
ng/l
0.11
63
555
50
458
1.12
0.25
1.5
1.6
22.51
18.97
nmol/l
0.64
42
389
114
1092
1.10
0.25
2.7
3.8
57.30
64.80
u/l
0.25
104
1021
6
82
0.72
0.24
2.7
3.8
12.67
582.86
u/ml
—
6
66
92
874
1.10
0.23
5.7
8.3
1.20
1.20
mmol/l
0.16
68
762
8
103
0.77
0.21
1.5
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
5.3
—
67.25
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
11.69
—
0
14
6
52
1.16
0.19
2.7
2.1
—
—
—
0
0
6
53
1.14
0.19
1.0
1.3
—
—
—
0
0
6
53
1.14
0.19
2.7
2.1
—
—
—
0
0
7
60
1.17
0.18
1.1
1.5
—
—
—
0
0
30
328
0.90
0.17
2.2
2.0
—
—
—
0
0
77
803
0.93
0.15
4.9
5.8
35.28
34.80
g/l
0.29
70
755
9
82
1.10
0.15
1.0
1.5
—
—
—
0
0
49
464
1.07
0.13
1.8
2.0
3.01
3.10
mg/l
0.11
41
402
16
143
1.13
0.12
2.1
2.9
36.64
41.24
u/l
0.23
11
125
5
44
1.14
0.10
1.8
8.5
—
138.88
—
0
8
42
400
1.06
0.09
1.7
1.8
449.35
400.50
pmol/l
0.54
34
339
8
76
1.05
0.07
1.8
3.0
—
1.10
—
0
8
29
277
1.05
0.05
1.3
1.2
9.90
1.01
u/ml
0.51
12
76
22
231
0.95
0.04
2.2
2.0
—
—
—
0
0
29
283
1.03
0.01
8.0
7.9
104.52
104.16
mmol/l
0.14
29
283
27
264
1.03
0.00
3.8
3.9
464.93
242.35
u/l
1.08
27
249
12
124
0.97
0.00
1.2
1.4
—
—
—
0
0
35
355
0.98
0.00
2.2
1.7
1639.70
1156.90
nmol/l
2.04
27
283
23
232
0.99
0.00
2.1
2.1
—
—
—
0
0
19
192
0.99
0.00
1.3
1.3
1.19
14.71
u/ml
—
10
67
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
69
0.87
-0.00
4.7
3.5
4.08
4.38
pmol/l
—
6
62
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.32
—
0
5
0
5
0.00
-0.00
0.0
4.6
—
5.00
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.2
—
94.33
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
39.14
—
0
7
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_PROSTATE – Carcinoma in situ of prostate
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).