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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_PROSTATE_EXALLC for full statistics.

Carcinoma in situ of prostate

DOID EFO Endpoint Browser

CD2_INSITU_PROSTATE

Grade III Prostatic Intraepithelial Neoplasia: High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

  • not C3_PROSTATE
207159

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D07.5&
  • Hospital discharge: ICD-9 — 2334
  • Cause of death: ICD-10 — D07.5&
  • Cause of death: ICD-9 — 2334
  • Cancer registry: Topography ICD-O-3 — C61
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

190

4. Check minimum number of events

None

190

5. Include endpoints

None

190

6. Filter based on genotype QC (FinnGen only)

190

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D07
Name in latin
Carcinoma in situ oculi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 190 - 190
Unadjusted period prevalence (%) 0.08 - 0.08
Median age at first event (years) 68.07 - 68.07

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
180
Matched controls
1799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8148/2-C61.9
ICD-O-3
Glandular intraepithelial neoplasia, high grade of prostate gland
+∞
200.5
153
*
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
11.2
40.5
89
144
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
12.6
40.0
80
107
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
14.5
29.6
52
49
N40
ICD-10 Finland
Hyperplasia of prostate
6.3
27.9
136
590
8140/2-C61.9
ICD-O-3
Adenocarcinoma in situ, NOS, of prostate gland
+∞
24.5
23
*
XKD00
NOMESCO Finland
Uroflowmetry
5.3
24.3
111
420
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.8
20.7
93
328
KE1DG
NOMESCO Finland
Very extensive MRI of prostate
24.8
16.0
22
10
TKE00
NOMESCO Finland
Needle biopsy of prostate
6.9
15.4
40
71
KEB00
NOMESCO Finland
Biopsy of prostate
14.3
14.9
25
20
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
3.9
13.1
63
217
KDE20
NOMESCO Finland
Removal of foreign body from urethra
34.9
12.8
16
5
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
9.4
9.0
18
21
XJH00
NOMESCO Finland
Transanal ultrasonography
3.8
8.9
40
127
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
5.1
7.2
22
48
C61
ICD-10 Finland
Malignant neoplasm of prostate
2.7
7.0
53
238
KC1GB
NOMESCO Finland
Cystography with X-ray
15.0
6.5
10
7

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_PROSTATE – Carcinoma in situ of prostate

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).