This is a non-core endpoint: only basic statistics are computed.
See its core counterpart CD2_INSITU_PROSTATE_EXALLC for full statistics.
Carcinoma in situ of prostate
CD2_INSITU_PROSTATE
Grade III Prostatic Intraepithelial Neoplasia: High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditions
|
207159 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
190 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D07
- Name in latin
- Carcinoma in situ oculi
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of prostate
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of prostate
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 190 | - | 190 |
| Unadjusted period prevalence (%) | 0.08 | - | 0.08 |
| Median age at first event (years) | 68.07 | - | 68.07 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8148/2-C61.9
ICD-O-3
Glandular intraepithelial neoplasia, high grade of prostate gland
+∞
200.5
153
*
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
11.2
40.5
89
144
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
12.6
40.0
80
107
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
14.5
29.6
52
49
N40
ICD-10 Finland
Hyperplasia of prostate
6.3
27.9
136
590
8140/2-C61.9
ICD-O-3
Adenocarcinoma in situ, NOS, of prostate gland
+∞
24.5
23
*
XKD00
NOMESCO Finland
Uroflowmetry
5.3
24.3
111
420
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.8
20.7
93
328
KE1DG
NOMESCO Finland
Very extensive MRI of prostate
24.8
16.0
22
10
TKE00
NOMESCO Finland
Needle biopsy of prostate
6.9
15.4
40
71
KEB00
NOMESCO Finland
Biopsy of prostate
14.3
14.9
25
20
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
3.9
13.1
63
217
KDE20
NOMESCO Finland
Removal of foreign body from urethra
34.9
12.8
16
5
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
9.4
9.0
18
21
XJH00
NOMESCO Finland
Transanal ultrasonography
3.8
8.9
40
127
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
5.1
7.2
22
48
C61
ICD-10 Finland
Malignant neoplasm of prostate
2.7
7.0
53
238
KC1GB
NOMESCO Finland
Cystography with X-ray
15.0
6.5
10
7
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
799
5.01
20.78
6.3
3.2
0.9
0.8
ug/l
2.87
136
554
111
586
3.15
13.55
4.7
3.8
—
—
—
0
0
121
671
3.21
13.55
4.9
3.4
—
—
—
0
0
165
1109
4.71
13.50
8.2
4.4
15.5
21.3
%
14.43
141
558
101
514
3.06
13.01
4.5
3.2
0.2
0.5
e6/l
1.80
91
393
123
747
2.83
10.68
6.0
4.8
0.0
0.0
estimate
0.00
44
142
124
759
2.82
10.56
4.5
3.5
0.0
0.0
estimate
0.00
44
129
180
1375
6.87
10.53
10.4
5.2
6.2
2.4
ug/l
17.40
173
1229
122
747
2.77
10.27
4.6
3.6
0.0
0.0
estimate
0.00
44
139
47
196
2.86
8.16
4.8
3.1
—
—
—
0
0
64
313
2.58
8.14
4.4
3.0
0.3
0.6
e6/l
1.62
50
186
78
423
2.43
7.91
4.8
3.7
0.0
0.0
estimate
0.50
42
128
180
1510
4.65
6.25
17.8
15.9
74.8
76.5
ml/min/173m2
0.64
168
1284
15
36
4.44
5.94
3.7
3.0
18.5
15.8
%
—
10
22
60
327
2.22
5.72
3.5
2.8
0.7
0.9
e6/l
0.49
46
198
182
1603
4.21
5.59
5.5
5.6
2.5
2.5
mmol/l
0.09
167
1464
178
1566
3.16
3.98
4.9
5.2
6.2
6.2
mmol/l
0.48
164
1415
174
1523
2.69
3.74
4.4
4.4
1.3
1.3
mmol/l
0.02
159
1385
183
1676
3.49
3.63
19.3
20.4
139.4
139.6
mmol/l
0.47
183
1641
183
1681
3.40
3.48
19.3
20.6
4.0
4.0
mmol/l
0.43
183
1648
176
1567
2.67
3.31
5.1
5.0
4.3
4.3
mmol/l
0.04
161
1442
175
1556
2.58
3.26
5.0
4.9
1.3
1.3
mmol/l
0.00
160
1418
10
32
3.24
2.69
1.4
3.5
105.1
104.5
mmol/l
—
10
32
100
779
1.60
2.60
4.7
4.3
—
—
—
0
0
126
1042
1.62
2.51
4.1
5.4
7.0
7.0
mmol/l
0.01
117
996
169
1518
2.03
2.45
6.7
7.0
40.7
41.4
mmol/mol
0.59
158
1413
171
1553
2.01
2.23
15.8
17.0
27.2
27.4
mg/l
0.02
152
1279
7
24
2.99
1.74
1.1
1.5
—
—
—
0
0
0
48
0.00
1.72
0.0
1.5
—
—
—
0
0
10
43
2.40
1.63
3.2
2.6
146.2
127.4
g/l
—
10
33
13
240
0.51
1.57
6.7
8.4
12.6
11.8
kpa
0.29
13
234
13
240
0.51
1.57
6.8
8.4
5.3
5.0
kpa
0.51
13
233
118
1030
1.38
1.35
3.1
3.0
15.0
14.9
pmol/l
0.19
103
895
130
1172
1.35
1.09
3.8
4.1
9.9
12.7
mm/h
1.65
120
1084
26
180
1.51
1.08
4.0
4.1
5.9
5.7
kpa
0.54
26
172
147
1354
1.38
1.05
3.8
3.8
2.0
2.1
mu/l
0.40
136
1199
5
22
2.31
1.04
1.4
1.4
—
—
—
0
0
22
150
1.53
0.98
3.0
3.2
4.4
4.6
kpa
0.14
22
142
0
30
0.00
0.98
0.0
3.3
—
41.0
—
0
7
147
1360
1.36
0.97
13.9
18.5
38.2
39.8
%
0.59
87
878
13
207
0.60
0.97
6.7
9.1
125.8
123.1
g/l
0.26
13
202
22
151
1.52
0.96
2.3
2.2
444.4
364.8
nmol/l
0.65
22
137
81
695
1.29
0.93
1.5
2.1
86.9
90.8
pmol/l
0.35
41
415
6
28
2.18
0.92
1.0
1.1
—
—
—
0
0
6
29
2.10
0.90
1.3
1.4
—
—
—
0
0
6
29
2.10
0.90
1.7
1.5
—
—
—
0
0
66
556
1.29
0.87
1.8
2.8
56.7
59.0
u/l
0.29
61
524
7
124
0.55
0.81
2.0
1.7
—
—
—
0
0
53
438
1.29
0.80
1.6
1.7
1.5
1.4
mmol/l
0.45
39
359
15
99
1.56
0.78
1.6
2.7
0.9
1.3
%
1.41
15
99
33
258
1.34
0.74
4.0
6.8
0.9
1.0
mmol/l
1.73
33
244
34
425
0.76
0.74
2.6
2.5
—
—
—
0
0
62
531
1.25
0.70
2.0
2.2
82.1
74.9
nmol/l
1.18
55
465
99
895
1.22
0.67
6.9
9.9
4.4
4.3
e9/l
0.03
82
784
5
30
1.68
0.62
1.0
1.4
2.2
4112.3
e6/l
—
5
23
83
742
1.21
0.61
4.3
4.1
40.0
47.6
ng/l
0.25
66
583
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
40
332
1.26
0.59
1.3
1.7
2.0
1.7
mg/l
0.17
29
262
97
883
1.20
0.59
5.4
7.8
12.1
13.4
umol/l
0.99
92
846
8
122
0.64
0.57
1.6
1.7
—
—
—
0
0
18
138
1.34
0.47
1.1
1.2
—
—
—
0
0
22
175
1.29
0.46
4.0
7.3
1.3
1.4
mmol/l
0.14
22
167
56
495
1.19
0.46
2.6
3.1
9219.4
8592.3
umol/l
0.02
48
432
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
1.4
—
0
6
5
35
1.44
0.39
3.0
2.2
—
—
—
0
0
57
512
1.16
0.38
2.3
2.2
161.6
407.3
u/l
1.01
52
481
5
79
0.62
0.36
2.2
3.6
9.6
609.7
u/ml
—
5
63
26
306
0.83
0.35
2.1
2.0
—
—
—
0
0
17
208
0.80
0.33
4.7
8.3
—
—
—
0
0
16
196
0.80
0.31
5.3
4.8
12.2
28.3
ug/l
0.32
11
162
7
55
1.28
0.30
1.7
1.4
—
—
—
0
0
14
173
0.79
0.30
1.3
1.2
1.1
16.3
u/ml
—
7
60
18
215
0.82
0.29
2.0
1.9
—
—
—
0
0
65
601
1.12
0.29
2.1
2.6
208.1
211.1
ug/l
0.03
57
546
16
132
1.23
0.26
1.9
2.6
71.4
62.0
ml/min/173m2
—
7
62
5
71
0.70
0.26
1.0
1.5
11.3
11.2
g/l
—
5
57
71
756
0.90
0.25
4.4
5.7
35.0
34.8
g/l
0.11
64
710
65
606
1.11
0.25
2.5
3.2
1417.2
1298.9
ng/l
0.07
58
523
106
1015
1.10
0.23
2.6
3.8
58.9
61.9
u/l
0.08
96
948
5
38
1.32
0.23
1.8
9.2
—
159.3
—
0
6
5
39
1.29
0.23
3.8
4.1
14.6
30.1
mg/l
—
5
27
7
93
0.74
0.23
1.6
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
5.6
—
66.4
—
0
11
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.5
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
86
820
1.09
0.20
4.7
8.0
1.2
1.2
mmol/l
0.26
61
713
0
14
0.00
0.20
0.0
2.2
—
—
—
0
0
6
52
1.16
0.19
1.0
1.0
—
—
—
0
0
7
59
1.19
0.18
1.1
1.5
—
—
—
0
0
35
328
1.08
0.12
1.6
2.0
32.3
29.6
s
1.87
35
318
18
163
1.12
0.11
2.6
3.0
68.9
65.9
g/l
0.88
18
145
10
86
1.17
0.11
5.9
3.7
23.7
23.8
mmol/l
—
10
78
45
428
1.07
0.11
1.4
1.6
22.3
19.0
nmol/l
0.52
37
361
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
20
215
0.92
0.08
1.9
2.1
—
—
—
0
0
10
111
0.90
0.06
6.9
10.2
24.7
24.5
mmol/l
—
10
105
39
377
1.04
0.05
1.7
1.8
450.3
402.1
pmol/l
0.48
31
322
25
259
0.96
0.03
1.4
1.2
10.7
1.0
u/ml
0.50
11
69
26
267
0.97
0.01
6.9
7.0
104.6
104.2
mmol/l
0.17
26
262
34
333
1.03
0.01
2.2
1.7
1618.7
1168.7
nmol/l
1.75
26
264
11
116
0.95
0.01
1.2
1.4
—
—
—
0
0
14
136
1.03
0.00
1.9
2.9
40.6
41.9
u/l
—
9
119
24
243
0.99
0.00
3.8
4.1
497.4
248.3
u/l
1.08
24
229
43
435
0.99
0.00
1.6
1.9
3.1
3.0
mg/l
0.06
35
374
74
737
1.01
0.00
2.1
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
5
51
0.98
0.00
3.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
7
79
0.88
0.00
1.0
1.4
—
—
—
0
0
7
70
1.00
0.00
1.9
3.1
—
1.1
—
0
8
0
7
0.00
0.00
0.0
5.4
—
—
—
0
0
0
9
0.00
0.00
0.0
3.2
—
94.3
—
0
9
0
7
0.00
0.00
0.0
2.4
—
242.1
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
6
61
0.98
0.00
4.7
3.1
4.1
4.3
pmol/l
—
6
54
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
39.1
—
0
7
5
50
1.00
0.00
3.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.3
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
12.0
—
0
6
0
7
0.00
0.00
0.0
5.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_PROSTATE – Carcinoma in situ of prostate
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).