Disorders of glossopharyngeal nerve

G6_DISGLO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G52.1
  • Hospital discharge: ICD-9 3521
  • Hospital discharge: ICD-8 35602
  • Cause of death: ICD-10 G52.1
  • Cause of death: ICD-9 3521
  • Cause of death: ICD-8 35602

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G52
Name in latin
Morbositates nervi glossopharyngei

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 479 287 186
Only index persons 424 266 158
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.76 53.17 56.97
Only index persons 53.35 52.25 55.20

-FinnGen-

Key figures

All Female Male
Number of individuals 65 39 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 54.55 53.63 55.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
59
Matched controls
591
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G52.1
ICD-10 Finland
Disorders of glossopharyngeal nerve
+∞
72.8
54
*
N03AF01
ATC
carbamazepine; oral, rectal
27.8
18.2
25
15
G50.0
ICD-10 Finland
Trigeminal neuralgia
+∞
10.7
10
*
N03AX16
ATC
pregabalin; oral
6.1
8.6
27
71
G50.1
ICD-10 Finland
Atypical facial pain
+∞
8.5
8
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
58
3.06
3.14
1.2
1.3
—
—
—
0
0
5
5
10.67
3.03
1.0
1.4
—
—
—
0
0
7
15
5.09
2.67
1.0
1.8
0.3
0.5
ug/l
—
7
15
8
20
4.41
2.66
1.8
1.9
—
—
—
0
0
35
235
2.06
2.12
12.3
6.4
1.2
1.2
mmol/l
0.88
30
213
6
15
4.29
2.09
1.2
1.1
—
—
—
0
0
20
113
2.11
1.88
3.5
1.9
1.0
1.4
mg/l
0.37
15
96
8
31
2.80
1.72
1.8
1.5
—
—
—
0
0
8
33
2.62
1.60
1.4
1.2
—
—
—
0
0
9
40
2.45
1.47
4.9
4.8
—
—
—
0
0
45
356
1.86
1.46
7.3
4.6
—
7348.4
—
0
8
9
41
2.38
1.44
2.3
3.4
—
—
—
0
0
29
206
1.74
1.32
2.4
1.9
81.1
88.6
pmol/l
0.63
13
91
20
130
1.78
1.21
3.8
4.4
—
—
—
0
0
30
221
1.66
1.16
3.5
3.2
—
—
—
0
0
5
21
2.49
1.11
3.2
3.3
—
—
—
0
0
29
215
1.63
1.08
10.4
7.6
1.3
1.2
inr
—
5
64
7
35
2.12
1.03
36.0
13.3
96.1
94.7
%
—
7
35
7
37
2.00
0.97
1.3
1.7
—
—
—
0
0
23
165
1.61
0.96
8.4
5.6
—
—
—
0
0
18
124
1.62
0.87
4.1
3.6
—
—
—
0
0
23
169
1.56
0.86
3.9
3.1
—
—
—
0
0
16
110
1.60
0.78
1.6
1.7
910.5
1280.9
nmol/l
—
10
78
16
111
1.59
0.75
2.1
1.6
442.6
466.6
pmol/l
0.16
11
91
5
93
0.50
0.73
4.0
2.8
0.9
0.8
mmol/l
—
5
87
5
26
2.00
0.72
1.4
1.1
—
—
—
0
0
7
44
1.66
0.67
2.9
2.5
—
—
—
0
0
5
29
1.78
0.65
1.2
1.1
—
—
—
0
0
19
142
1.48
0.64
2.7
3.0
6603.9
40.4
mg/l
0.77
12
91
8
52
1.61
0.62
32.6
10.7
108.8
122.3
g/l
—
8
52
0
19
0.00
0.61
0.0
2.9
—
—
—
0
0
11
73
1.61
0.61
3.3
1.7
—
—
—
0
0
6
35
1.79
0.59
36.3
9.7
26.2
26.1
mmol/l
—
6
35
6
36
1.73
0.58
5.8
5.0
—
—
—
0
0
21
163
1.43
0.58
2.9
2.5
—
—
—
0
0
6
38
1.64
0.56
3.0
2.2
—
—
—
0
0
9
64
1.47
0.54
28.7
9.4
1.8
1.8
mmol/l
—
9
53
15
112
1.44
0.50
4.2
4.0
—
1.0
—
0
8
27
225
1.34
0.48
1.9
2.2
—
—
—
0
0
55
512
1.48
0.46
4.8
4.6
1.5
1.5
mmol/l
0.06
50
462
8
59
1.41
0.43
1.6
1.5
—
—
—
0
0
35
307
1.30
0.43
7.7
9.4
3.6
4.1
e9/l
0.60
27
265
8
60
1.38
0.42
1.4
1.3
—
—
—
0
0
42
378
1.31
0.42
4.4
4.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.8
—
—
—
0
0
9
66
1.42
0.41
1.2
1.4
—
—
—
0
0
30
261
1.28
0.38
6.8
5.9
0.2
0.2
e9/l
0.46
23
225
39
351
1.28
0.37
7.7
4.5
—
—
—
0
0
29
252
1.27
0.37
6.7
5.8
0.5
0.6
e9/l
0.37
23
219
6
43
1.43
0.36
39.3
11.0
—
—
—
0
0
18
147
1.31
0.36
2.5
3.0
6.9
6.8
mmol/l
0.02
12
123
29
253
1.26
0.35
6.7
5.8
0.0
0.0
e9/l
0.27
23
219
11
141
0.74
0.34
1.9
1.4
—
—
—
0
0
7
54
1.33
0.31
1.7
2.6
4.9
7.5
umol/l
—
7
48
13
160
0.77
0.30
3.8
3.6
—
—
—
0
0
29
257
1.23
0.30
7.3
5.8
1.6
2.0
e9/l
0.69
23
224
9
74
1.25
0.27
1.4
1.8
—
—
—
0
0
21
182
1.23
0.26
2.3
3.0
2.3
2.4
mmol/l
0.27
16
161
57
546
1.36
0.23
27.1
16.2
4.0
4.0
mmol/l
0.01
57
530
10
123
0.78
0.23
4.9
7.0
—
—
—
0
0
27
243
1.19
0.22
7.6
9.3
0.0
0.0
e9/l
0.71
21
200
9
111
0.78
0.22
1.6
2.7
2.4
2.5
mmol/l
—
9
100
5
42
1.21
0.22
1.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
4.2
—
—
—
0
0
0
12
0.00
0.21
0.0
4.2
—
3.9
—
0
12
0
12
0.00
0.21
0.0
4.2
—
105.6
—
0
12
22
196
1.19
0.20
4.3
3.6
3.4
97.2
e6/l
1.24
11
146
8
69
1.18
0.17
1.5
1.4
—
—
—
0
0
9
80
1.14
0.16
3.0
1.8
9.9
13.1
umol/l
—
9
74
57
554
1.23
0.15
24.7
16.7
75.4
77.6
umol/l
0.37
57
554
42
440
0.87
0.15
20.5
17.5
13.8
13.9
%
0.28
42
429
55
534
1.19
0.13
22.7
13.9
24.8
22.7
mg/l
0.17
47
412
17
155
1.13
0.10
2.8
3.9
2.5
6.0
mg/mmol
—
8
98
5
43
1.18
0.10
1.6
2.4
10.0
10.6
g/l
—
5
38
16
175
0.89
0.10
3.3
3.0
4.1
42.6
e6/l
—
10
133
6
53
1.15
0.09
6.0
3.9
6.2
5.7
kpa
—
6
53
6
53
1.15
0.09
6.0
4.0
—
—
—
0
0
11
123
0.87
0.09
6.3
4.7
—
—
—
0
0
18
194
0.90
0.08
2.6
3.2
—
—
—
0
0
7
64
1.10
0.08
1.7
1.4
—
—
—
0
0
58
584
0.94
0.08
31.2
20.5
30.4
30.4
pg
0.10
58
574
58
584
0.94
0.08
31.6
20.5
4.3
4.5
e12/l
0.69
58
565
58
584
0.94
0.08
31.6
20.6
254.5
246.0
e9/l
0.59
58
568
58
584
0.94
0.08
31.3
20.5
91.5
91.3
fl
0.10
58
574
58
584
0.94
0.08
31.5
20.6
7.0
6.7
e9/l
0.17
58
564
58
584
0.94
0.08
31.6
20.7
131.8
134.7
g/l
0.75
58
574
17
157
1.11
0.08
3.5
2.8
—
—
—
0
0
57
556
1.20
0.07
17.8
13.2
—
—
—
0
0
15
162
0.90
0.07
5.1
4.4
—
—
—
0
0
17
162
1.07
0.02
3.3
2.8
0.0
0.4
e6/l
2.51
11
119
46
466
0.96
0.00
24.8
15.2
38.4
39.1
%
0.20
33
327
16
156
1.03
0.00
7.2
4.9
1.3
2.7
ug/l
1.18
11
136
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
25.8
—
0
8
0
5
0.00
0.00
0.0
1.0
—
329.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
7.0
—
0
5
0
8
0.00
0.00
0.0
1.3
—
4.2
—
0
8
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
12.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.9
—
0
5
7
74
0.94
0.00
3.0
1.8
2.5
2.3
g/l
—
7
69
0
5
0.00
0.00
0.0
1.0
—
13.3
—
0
5
5
51
0.98
0.00
1.2
1.7
0.2
0.2
g/l
—
5
46
7
71
0.98
0.00
1.0
1.3
—
—
—
0
0
7
70
1.00
0.00
2.9
1.9
14.9
21.0
%
—
7
65
0
5
0.00
0.00
0.0
1.2
—
8.6
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
31.9
—
0
7
0
5
0.00
0.00
0.0
3.0
—
3.5
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_DISGLO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_DISGLO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_DISGLO – Disorders of glossopharyngeal nerve

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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