Changes in corneal membranes

H7_CORNEALMEMBRANE

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H18.3 Cause of death: ICD-10 — H18.3 2 out of 7 registries used, show all original rules.	89
4. Check minimum number of events None	89
5. Include endpoints None	89
6. Filter based on genotype QC (FinnGen only)	89

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H18
Name in latin: Abnormitates membranarum cornealium

NAME	H7_CORNEALMEMBRANE
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H183
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H183
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Changes in corneal membranes based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	414	262	151
Only index persons	402	255	147
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.95	63.82	58.75
Only index persons	61.37	62.88	58.75

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	89	62	27
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	63.62	63.48	63.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
721

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H18.3

ICD-10 Finland

Changes in corneal membranes

+∞

103.4

H18.5

ICD-10 Finland

Hereditary corneal dystrophies

253.0

19.5

CG2T4

NOMESCO Finland

Topography assessment of cornea

+∞

17.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

8.8

15.3

217

CG2X4

NOMESCO Finland

Optical coherence tomography (OCT) of cornea

+∞

12.9

H16.0

ICD-10 Finland

Corneal ulcer

63.8

9.9

XCW99

NOMESCO Finland

Other investigative procedure of eye

8.1

9.8

CG2S4

NOMESCO Finland

Photography of cornea

+∞

9.6

Z96.1

ICD-10 Finland

Presence of intraocular lens

6.8

8.7

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

8.5

8.2

H16.9

ICD-10 Finland

Keratitis, unspecified

+∞

6.3

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

+∞

6.3

H18.4

ICD-10 Finland

Corneal degeneration

+∞

6.3

ZXA10

NOMESCO Finland

Bilateral

4.3

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3001604) Monocytes [#/volume] in Blood

346

2.80

5.14

9.3

6.1

0.5

e9/l

0.11

304

(3006315) Basophils [#/volume] in Blood

347

2.79

5.10

9.3

6.1

0.0

e9/l

0.03

306

(42870588) Differential panel, method unspecified - Blood

212

2.73

5.05

9.9

5.5

—

(3022096) Basophils/100 leukocytes in Blood

314

2.70

4.96

10.1

5.8

0.6

0.7

0.20

294

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

124

2.84

4.57

2.6

2.8

1.3

1.0

e6/l

0.29

(3006504) Eosinophils/100 leukocytes in Blood

329

2.51

4.29

10.2

5.8

2.8

2.7

0.27

309

(3002030) Lymphocytes/100 leukocytes in Blood

341

2.48

4.17

10.1

5.8

29.2

28.8

0.10

317

(3037522) Nuclear Ab [Titer] in Serum

2.88

4.15

1.6

1.3

1248.0

761.4

titre

—

(3019069) Monocytes/100 leukocytes in Blood

333

2.46

4.13

10.2

6.0

8.4

8.2

0.33

314

(3002256) Pathology report gross observation

2.72

3.63

1.4

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

111

2.59

3.53

2.9

0.4

2.7

e6/l

1.33

(3011397) Hemoglobin [Presence] in Urine by Test strip

170

2.38

3.51

2.3

3.7

—

(3018095) Leukocytes [#/volume] in Urine

271

2.23

3.39

3.4

3.9

173.8

73.5

e6/l

0.51

186

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.14

3.34

1.3

1.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.66

3.31

1.5

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

267

2.18

3.21

3.2

3.1

—

(40758558) Short blood count panel - Blood

187

2.22

3.06

9.6

7.3

—

(36304419) Bacteria [Presence] in Urine

205

2.17

2.98

3.0

3.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

7.05

2.91

1.5

1.7

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

7.05

2.91

1.5

1.7

—

(3044889) 12 lead EKG panel

509

2.28

2.85

5.2

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

673

2.86

2.84

19.2

14.0

39.4

40.2

0.45

500

(3003694) ABO and Rh group [Type] in Blood

184

2.15

2.83

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

480

2.19

2.78

4.5

4.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

701

3.16

2.70

17.4

12.7

77.7

81.0

ml/min/173m2

0.64

576

(3030467) Casts [#/volume] in Urine by Automated count

206

2.05

2.60

3.3

0.6

0.4

e6/l

0.22

153

(3052851) Hemolysis interference index of Serum or Plasma

3.89

2.43

1.6

3.4

—

(3015736) pH of Urine

283

1.92

2.32

2.6

3.6

—

(3023368) Bacteria identified in Blood by Culture

172

2.02

2.31

6.2

4.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.86

2.31

6.8

3.8

57.0

64.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.86

2.31

4.0

2.2

3.1

6.3

e9/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

743

3.32

2.28

19.6

14.8

4.0

mmol/l

0.04

723

(3019550) Sodium [Moles/volume] in Serum or Plasma

743

3.32

2.28

19.6

14.8

139.7

139.8

mmol/l

0.16

724

(3004789) Transferrin [Mass/volume] in Serum or Plasma

103

2.21

2.28

2.3

2.0

2.3

2.4

g/l

0.65

(3007164) IgA [Mass/volume] in Serum or Plasma

149

2.05

2.27

1.7

1.3

2.2

2.3

g/l

0.02

(3002582) Erythrocytes [#/volume] in Urine

232

1.93

2.26

3.2

3.3

42.8

24.3

e6/l

0.45

174

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

243

1.89

2.18

2.8

3.1

32.1

29.2

u/l

0.23

234

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.71

2.10

3.0

1.6

11.8

12.3

mg/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

130

2.04

2.07

4.9

3.5

251.3

193.6

ng/l

0.10

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

720

2.76

2.06

20.2

13.3

27.3

22.3

mg/l

0.48

554

(3022948) Iron [Moles/volume] in Serum or Plasma

109

2.08

1.97

2.2

2.0

12.2

14.6

umol/l

0.64

101

(4035726)

2.27

1.94

1.7

1.3

—

(3021589) Normoblasts [#/volume] in Blood

315

1.78

1.91

13.9

9.1

0.0

e9/l

0.00

256

(40768804) Tissue Pathology biopsy report

308

1.77

1.85

2.7

2.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

2.28

1.76

1.7

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

285

1.73

1.9

98.8

99.8

pmol/l

0.06

138

(36660697) Celiac disease serology panel - Serum

2.42

1.71

1.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

2.95

1.69

2.0

2.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

362

1.71

1.67

6.8

5.4

1.2

mmol/l

0.20

305

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.11

1.66

2.0

1.9

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

3.72

1.64

1.6

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.99

1.53

1.7

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.99

1.53

1.3

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

2.59

1.53

1.7

1.6

—

(40761511) CBC panel - Blood by Automated count

767

2.69

1.51

15.2

11.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

105

1.90

1.47

2.1

1.9

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.85

1.46

3.3

1.5

0.3

0.2

g/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.16

1.46

1.4

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

172

1.72

1.42

4.2

4.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

335

1.62

1.41

2.9

3.5

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

2.72

1.39

1.5

2.8

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.72

1.39

1.5

2.8

0.0

g/l

—

(3008898) HLA-B27 [Presence]

2.60

1.32

1.0

1.1

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

2.60

1.32

1.5

2.7

0.0

g/l

—

(3044640) Blood type and Crossmatch panel - Blood

219

1.64

1.32

1.7

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

125

1.77

1.32

1.4

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.94

1.30

2.1

1.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

468

1.61

1.30

4.2

4.7

—

223.8

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

2.40

1.21

1.5

2.6

0.0

1.5

g/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

568

1.63

1.17

5.3

4.3

14.8

pmol/l

0.00

514

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.59

1.16

1.4

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

105

1.77

1.16

1.5

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.44

1.15

2.0

2.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.36

1.13

2.1

2.0

—

(3000330) Specific gravity of Urine by Test strip

2.36

1.13

4.7

3.0

—

(3003338) MCHC [Mass/volume]

636

1.69

1.12

24.3

17.7

329.5

331.8

g/l

1.69

636

(3032080) INR in Blood by Coagulation assay

273

1.54

1.12

7.4

7.5

1.3

1.2

inr

—

(3000991) Gas panel - Venous blood

2.04

1.11

2.8

5.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

158

1.61

1.08

1.7

1.8

0.7

1.0

mg/l

0.60

125

(3004588) Protein electrophoresis panel - Serum or Plasma

2.02

1.06

1.8

3.5

—

(3022145) Colonoscopy Study observation

1.79

1.05

1.3

—

(40768443) Skin Pathology biopsy report

2.02

0.99

1.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.88

0.99

2.5

1.9

56.0

56.9

ml/min/173m2

—

(3045414) Leukocytes [Presence] in Urine

2.22

0.93

2.0

1.8

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.22

0.93

1.5

2.5

3.5

3.6

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.22

0.93

1.5

2.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.73

0.90

1.5

—

(3012544) pH of Venous blood

1.85

0.88

2.8

3.5

—

(3000492) Spirometry study

1.85

0.88

1.3

1.5

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.71

0.87

2.5

2.8

1.8

0.01

(3009508) Creatinine [Moles/volume] in Urine

193

1.49

0.87

3.5

2.9

7.9

7.2

mmol/l

0.24

159

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.94

0.83

4.8

6.5

—

(3000494) Fungus identified in Specimen by Culture

1.62

0.78

1.5

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.72

0.70

1.0

1.5

—

(3026008) Bacteria identified in Urine by Culture

201

1.41

0.70

3.0

3.4

—

(3012516) Albumin [Mass/volume] in Urine

183

1.43

0.69

4.0

3.0

50.5

38.6

mg/l

0.16

113

(3022621) pH of Urine by Test strip

1.64

0.67

2.6

2.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.62

0.62

1.8

1.6

—

(4034850)

0.00

0.61

0.0

8.1

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.61

0.0

3.8

—

21.3

—

(40768797) Stomach Pathology biopsy report

107

1.48

0.60

1.1

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

197

1.37

0.60

4.5

3.7

10.7

6.1

mg/mmol

0.28

122

(40761535) Cells panel - Urine sediment

1.53

0.56

3.1

3.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

139

1.37

0.48

1.4

1.3

0.9

6.0

u/ml

—

(3019060) Gas panel - Arterial blood

1.46

0.47

3.3

4.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

262

1.28

0.46

4.5

3.8

51.5

42.4

ng/l

0.09

175

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

459

1.26

0.45

3.2

2.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.54

0.42

1.6

1.1

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.41

0.0

1.8

—

9005.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.9

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.0

—

2.2

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.2

—

15.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.39

0.0

1.6

—

(3042936) Bacteria identified in Isolate by Culture

1.37

0.38

1.4

2.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.46

0.36

2.7

5.7

1.6

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.46

0.36

2.7

5.7

0.4

0.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

270

1.23

0.35

3.6

3.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.36

0.34

1.5

—

(3013512) EKG study

217

0.79

0.34

3.6

3.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

112

1.30

0.30

3.1

4.1

15.1

20.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

143

1.23

0.25

3.6

4.4

1.3

1.6

ug/l

0.67

126

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.37

0.24

1.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.33

0.23

11.0

5.0

24.5

25.2

mmol/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

136

1.22

0.22

1.7

1.3

14.3

33.6

iu/ml

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.20

0.22

1.2

2.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.20

0.22

1.2

1.1

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.21

0.0

2.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

2.3

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(4268621)

0.00

0.21

0.0

1.8

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

3.1

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

19.9

—

(4146454)

0.00

0.21

0.0

3.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.3

—

56.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

2.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

3.1

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.20

0.0

1.5

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.2

—

7.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.20

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.25

0.19

2.1

1.4

—

(4010399)

1.20

0.18

1.6

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.18

4.7

4.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.21

0.17

2.1

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

159

1.17

0.16

1.5

2.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.19

0.16

1.1

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.79

0.15

1.3

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

136

0.86

0.12

1.3

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.18

0.11

10.0

7.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.07

0.09

1.0

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

519

0.96

0.03

2.8

40.5

40.7

u/l

0.01

494

(3041096) Erythrocytes [Presence] in Urine by Automated

192

1.05

0.02

3.5

—

(1761868) Lipid panel - Serum or Plasma

264

1.03

0.00

3.1

2.5

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.6

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

5.6

—

(3019977) pH of Arterial blood

0.00

0.0

1.9

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.0

—

315.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1448.0

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

6.4

—

(40761536) Microorganisms panel - Urine sediment

0.92

0.00

4.2

4.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.87

0.00

1.4

1.7

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.1

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.96

0.00

8.0

3.9

1.3

1.2

mmol/l

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

(44790048)

0.00

0.0

1.8

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.3

—

10.9

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.7

—

1233.5

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

20.1

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

2.8

—

21.7

—

(21494755) Public health laboratory ask at order entry panel

0.92

0.00

1.4

1.3

—

(44790049)

0.00

0.0

1.8

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.2

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.6

—

(44790047)

0.00

0.0

1.8

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

28.8

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

52.2

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(44806118)

0.00

0.0

1.8

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

18.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEALMEMBRANE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEALMEMBRANE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_CORNEALMEMBRANE – Changes in corneal membranes

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Changes in corneal membranes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints