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Changes in corneal membranes

DOID EFO Endpoint Browser PheWeb

H7_CORNEALMEMBRANE

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.3
  • Cause of death: ICD-10 — H18.3

2 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

104

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Abnormitates membranarum cornealium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 414 262 151
Only index persons 402 255 147
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.95 63.82 58.75
Only index persons 61.37 62.88 58.75

-FinnGen-

Key figures

All Female Male
Number of individuals 104 72 32
Unadjusted period prevalence (%) 0.02 0.03 0.01
Median age at first event (years) 64.65 64.85 64.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
106
Matched controls
1060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
152.9
106
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
13.4
26.5
92
349
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
26.1
24
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
214.4
18.1
18
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.6
17.3
29
50
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
16.0
15
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
12.8
31
75
CJB10
NOMESCO Finland
Laser discission of secondary cataract
6.7
12.2
22
40
H26.4
ICD-10 Finland
After-cataract
6.0
12.2
25
52
H18.4
ICD-10 Finland
Corneal degeneration
+∞
11.7
11
*
H16.0
ICD-10 Finland
Corneal ulcer
18.1
11.3
17
11
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.3
10.7
25
58
CG2S4
NOMESCO Finland
Photography of cornea
+∞
10.6
10
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.8
9.2
24
61
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
8.4
8
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.7
8.2
16
19
ZXA10
NOMESCO Finland
Bilateral
3.6
7.9
34
124
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.7
6.3
16
39
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
6.3
6
*
CGE10
NOMESCO Finland
Keratectomy
+∞
6.3
6
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
6.3
6
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.8
6.1
50
259

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
61
391
2.32
4.31
8.7
6.1
—
—
—
0
0
69
490
2.17
3.51
10.9
9.8
3.92
4.06
e9/l
0.23
64
436
57
377
2.11
3.48
9.6
5.6
0.62
0.66
%
0.24
57
352
61
419
2.07
3.32
8.8
5.9
0.56
0.55
e9/l
0.14
55
367
61
419
2.07
3.32
8.9
5.9
0.04
0.04
e9/l
0.05
55
366
35
199
2.13
3.12
2.3
3.6
—
—
—
0
0
9
21
4.58
3.07
1.3
1.0
—
—
—
0
0
62
439
1.99
2.99
8.9
6.0
0.19
0.17
e9/l
0.30
57
394
49
322
1.97
2.91
3.2
3.7
160.26
80.91
e6/l
0.42
38
221
57
395
1.96
2.89
9.7
5.7
2.87
2.65
%
0.36
57
372
57
399
1.93
2.77
9.7
5.9
8.56
8.21
%
0.51
57
377
58
409
1.92
2.75
9.6
5.7
29.30
28.56
%
0.22
58
386
37
224
2.00
2.75
1.3
1.3
—
—
—
0
0
24
124
2.21
2.68
1.6
1.3
1248.00
674.59
titre
—
5
37
37
226
1.98
2.67
8.9
6.6
—
—
—
0
0
25
135
2.11
2.49
2.8
2.7
0.42
2.78
e6/l
1.80
13
69
39
248
1.91
2.48
2.8
3.0
—
—
—
0
0
22
114
2.17
2.43
1.4
1.2
—
—
—
0
0
7
17
4.33
2.40
6.1
3.6
55.43
63.88
%
—
7
17
7
17
4.33
2.40
3.7
2.4
2.99
5.88
e9/l
—
7
17
78
627
1.92
2.28
5.0
3.6
—
—
—
0
0
8
25
3.37
2.14
1.6
3.1
—
—
—
0
0
26
154
1.91
2.00
4.4
3.4
219.24
161.97
ng/l
0.12
21
118
57
429
1.71
1.96
4.0
5.1
0.00
0.00
estimate
—
6
71
37
247
1.77
1.95
3.1
3.1
0.55
0.54
e6/l
0.02
29
184
28
172
1.85
1.93
1.6
1.4
2.30
2.23
g/l
0.05
15
109
57
431
1.70
1.91
2.7
3.8
0.00
0.00
estimate
—
6
72
7
22
3.33
1.91
3.0
2.5
11.84
13.39
mg/l
—
7
22
40
276
1.72
1.87
3.0
3.2
39.53
51.91
e6/l
0.19
34
209
32
207
1.78
1.86
6.1
4.2
—
—
—
0
0
98
894
2.27
1.65
18.2
14.9
139.68
139.82
mmol/l
0.26
98
870
21
124
1.86
1.62
2.3
2.2
2.26
2.38
g/l
0.63
21
115
12
57
2.25
1.62
1.0
1.1
—
—
—
0
0
70
574
1.65
1.61
4.5
4.2
—
—
—
0
0
22
133
1.83
1.58
2.2
2.2
12.09
14.05
umol/l
0.55
22
125
13
65
2.14
1.56
2.8
5.9
—
—
—
0
0
55
428
1.59
1.55
2.8
3.8
0.00
0.00
estimate
—
7
78
98
896
2.24
1.52
18.2
14.9
3.98
3.98
mmol/l
0.07
98
871
6
22
2.83
1.45
1.0
1.2
—
—
—
0
0
6
23
2.70
1.39
1.3
1.1
—
—
—
0
0
10
47
2.25
1.38
1.6
1.6
—
—
—
0
0
47
365
1.52
1.27
2.6
2.0
—
—
—
0
0
15
86
1.87
1.27
1.7
1.4
—
—
—
0
0
28
193
1.61
1.27
1.6
1.8
0.65
1.02
mg/l
1.01
21
151
54
434
1.50
1.23
6.4
5.6
1.21
1.22
mmol/l
0.49
48
372
48
377
1.50
1.22
13.6
9.6
0.00
0.00
e9/l
-0.00
40
307
8
40
2.08
1.15
2.0
2.0
—
—
—
0
0
7
30
2.43
1.14
2.0
3.1
—
—
—
0
0
77
674
1.52
1.10
4.9
4.1
14.80
14.82
pmol/l
0.02
72
608
99
925
2.06
1.07
14.1
11.7
—
—
—
0
0
7
36
2.01
0.99
4.7
3.0
—
—
—
0
0
43
342
1.43
0.98
2.0
1.9
98.82
99.77
pmol/l
0.06
17
163
34
259
1.46
0.97
1.7
2.0
—
—
—
0
0
12
70
1.81
0.97
2.5
3.2
—
—
—
0
0
65
558
1.43
0.97
4.0
4.6
—
207.77
—
0
13
7
37
1.95
0.96
1.3
1.3
—
—
—
0
0
18
119
1.62
0.96
1.4
1.6
—
—
—
0
0
99
931
1.96
0.96
19.9
15.5
75.65
74.78
umol/l
0.16
99
931
6
27
2.29
0.95
3.3
1.4
0.26
0.25
g/l
—
6
27
47
382
1.41
0.95
19.2
12.4
1.42
1.25
inr
—
10
111
10
56
1.87
0.91
1.7
3.5
—
—
—
0
0
6
29
2.13
0.91
1.5
2.5
37.95
38.01
g/l
—
6
29
8
47
1.76
0.83
8.1
4.8
24.99
25.09
mmol/l
—
8
47
12
74
1.70
0.82
1.4
1.3
—
—
—
0
0
32
249
1.41
0.81
2.8
3.3
—
—
—
0
0
6
33
1.87
0.80
1.0
1.1
—
—
—
0
0
0
25
0.00
0.80
0.0
3.5
—
19.39
—
0
14
0
25
0.00
0.80
0.0
9.8
—
—
—
0
0
15
101
1.57
0.75
2.2
6.0
103.73
103.49
mmol/l
0.08
15
101
11
69
1.66
0.71
1.3
1.4
—
—
—
0
0
14
95
1.55
0.68
2.5
2.7
1.74
1.77
%
0.05
14
88
14
96
1.53
0.65
1.5
1.4
—
—
—
0
0
15
105
1.50
0.64
1.3
1.2
—
—
—
0
0
83
767
1.38
0.64
22.4
17.3
330.64
331.61
g/l
0.50
83
767
92
865
1.48
0.63
4.1
4.4
5.79
5.88
mmol/l
0.54
87
793
8
52
1.58
0.61
2.4
2.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.7
—
40211.27
—
0
15
6
35
1.76
0.59
2.0
1.8
—
—
—
0
0
15
108
1.45
0.57
1.5
1.3
—
—
—
0
0
92
872
1.42
0.53
18.9
13.2
26.62
21.58
mg/l
0.53
72
669
17
130
1.37
0.47
1.1
1.2
—
—
—
0
0
7
49
1.46
0.47
3.0
6.8
1.63
1.44
%
—
7
49
7
49
1.46
0.47
3.0
6.8
0.40
0.71
%
—
7
49
28
232
1.28
0.46
3.9
3.0
47.80
57.91
mg/l
0.13
18
149
37
319
1.25
0.44
4.1
4.1
45.28
49.58
ng/l
0.05
25
216
7
102
0.66
0.42
1.3
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
13.43
—
0
14
0
19
0.00
0.39
0.0
1.0
—
2.86
—
0
14
29
247
1.24
0.38
4.2
3.5
10.05
9.12
mg/mmol
0.05
16
155
21
174
1.26
0.35
3.7
4.4
1.18
1.70
ug/l
1.41
21
155
6
46
1.32
0.33
1.5
1.5
—
—
—
0
0
8
66
1.23
0.27
1.5
1.4
—
—
—
0
0
22
254
0.83
0.27
3.4
3.4
—
—
—
0
0
0
10
0.00
0.21
0.0
3.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
19.90
—
0
10
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
0.24
—
0
7
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
6
51
1.19
0.20
2.3
2.6
129.33
125.96
g/l
—
6
51
7
58
1.22
0.18
3.3
4.2
—
—
—
0
0
19
170
1.14
0.15
1.4
1.3
0.93
8.62
u/ml
—
8
66
8
96
0.82
0.14
1.4
1.3
—
—
—
0
0
22
241
0.89
0.14
3.3
3.5
—
—
—
0
0
14
123
1.16
0.13
1.4
2.0
—
—
—
0
0
5
44
1.14
0.10
1.8
2.4
0.52
0.68
%
—
5
44
5
48
1.04
0.09
1.2
1.1
—
—
—
0
0
6
54
1.12
0.09
1.0
1.2
—
—
—
0
0
6
71
0.84
0.08
1.3
1.6
—
—
—
0
0
33
329
1.00
0.00
3.1
2.6
—
—
—
0
0
22
223
0.98
0.00
3.3
4.3
0.00
0.00
estimate
—
5
72
17
175
0.97
0.00
1.6
1.3
14.33
27.44
iu/ml
—
6
73
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
32.89
—
0
8
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
163.97
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1.71
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
9
92
0.98
0.00
1.1
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
28.80
—
0
5
5
51
0.98
-0.00
1.2
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1448.00
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
75.33
—
0
6
0
6
0.00
-0.00
0.0
19.7
—
1233.50
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
6.38
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
6.43
—
0
9
0
6
0.00
-0.00
0.0
1.5
—
10.67
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
290.33
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.86
-0.00
3.7
4.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
32.95
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEALMEMBRANE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEALMEMBRANE.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: H7_CORNEALMEMBRANE – Changes in corneal membranes

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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