corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3642 |
4. Check minimum number of eventsNone |
3642 |
5. Include endpoints |
3755 |
6. Filter based on genotype QC (FinnGen only) |
3755 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H15-H22
- Name in latin
- Aliae morbositates corneae
Similar endpoints
↥List of similar endpoints to
Other disorders of cornea
based on the number of shared cases.
Similar with more cases:
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27514 | 14348 | 13021 |
| Only index persons | 25515 | 13289 | 12226 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.41 | 0.36 |
| Only index persons | 0.48 | 0.49 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 52.38 | 59.94 | 44.18 |
| Only index persons | 51.37 | 58.67 | 43.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3755 | 2171 | 1584 |
| Unadjusted period prevalence (%) | 0.72 | 0.74 | 0.70 |
| Median age at first event (years) | 55.30 | 57.13 | 52.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3287
- Matched controls
- 32869
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
221.6
323.0
408
21
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
1330.9
323.0
950
10
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
323.0
402
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.3
323.0
944
1728
H18.8
ICD-10 Finland
Other specified disorders of cornea
3280.0
323.0
796
*
H18.4
ICD-10 Finland
Corneal degeneration
1231.0
323.0
429
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.7
323.0
2241
8981
CG2T4
NOMESCO Finland
Topography assessment of cornea
214.8
323.0
509
28
H16.0
ICD-10 Finland
Corneal ulcer
45.9
323.0
609
162
H18.6
ICD-10 Finland
Keratoconus
2226.4
323.0
817
5
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.3
305.2
940
1974
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
262.0
248
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.9
250.4
801
1714
TCG10
NOMESCO Finland
Removal of sutures from cornea
129.8
246.4
263
22
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
232.1
220
*
CG2S4
NOMESCO Finland
Photography of cornea
210.7
228.6
235
12
H16.9
ICD-10 Finland
Keratitis, unspecified
225.7
225.7
231
11
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
301.5
222.4
224
8
H18.2
ICD-10 Finland
Other corneal oedema
+∞
218.2
207
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.2
197.2
1529
7072
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
187.3
178
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
179.3
1313
5725
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
159.7
152
*
WX140
NOMESCO Finland
Parabulbar anesthesy
7.6
140.3
350
510
S01AD03
ATC
aciclovir; ophthalmic
9.2
137.8
302
357
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.5
133.1
524
1328
H25.1
ICD-10 Finland
Senile nuclear cataract
2.9
132.9
1061
4690
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
234.5
131.9
135
6
XCK10
NOMESCO Finland
Photography of fundus of eye
4.0
131.5
590
1690
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
66.4
120.9
140
22
H04.10
ICD-10 Finland
Dry eye syndrome
4.0
114.8
521
1494
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
139.5
113.9
121
9
S01ED01
ATC
timolol; ophthalmic
7.7
112.4
276
389
Z3229
NOMESCO Finland
Other healthcare associate professional
4.0
111.7
493
1377
ZXA10
NOMESCO Finland
Bilateral
2.8
110.5
858
3654
H18.7
ICD-10 Finland
Other corneal deformities
+∞
110.0
105
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
987.2
98.6
96
*
WX002
NOMESCO Finland
Sedation and analgesia
2.6
97.1
852
3855
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
96.6
729
3015
S01ED51
ATC
timolol, combinations; ophthalmic
4.2
94.2
386
998
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
114.6
92.5
100
9
H26.4
ICD-10 Finland
After-cataract
3.6
90.0
454
1405
H52.2
ICD-10 Finland
Astigmatism
12.7
89.6
164
135
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
25.4
88.3
125
51
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
86.8
83
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
85.8
408
1200
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
118.3
85.4
92
8
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
83.7
80
*
ZXA05
NOMESCO Finland
Left side
2.3
83.6
1009
5327
3604
FHL
Penetration of the cornea
+∞
81.6
78
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
8.2
81.5
189
242
H18.3
ICD-10 Finland
Changes in corneal membranes
270.4
77.8
79
*
ZXA00
NOMESCO Finland
Right side
2.2
76.9
1032
5679
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
74.2
71
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.0
71.8
314
854
H17.8
ICD-10 Finland
Other corneal scars and opacities
147.1
68.2
72
5
CGE10
NOMESCO Finland
Keratectomy
+∞
67.9
65
*
S01EC01
ATC
acetazolamide; systemic
7.9
67.2
159
210
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
66.9
64
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
661.2
66.2
65
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
5.7
65.4
197
363
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
8.7
64.5
143
170
CGD40
NOMESCO Finland
Implantation of intracorneal ring segments
+∞
63.7
61
*
H17.1
ICD-10 Finland
Other central corneal opacity
619.5
62.0
61
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
318.7
61.6
62
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
97.7
61.1
67
7
S01EA03
ATC
apraclonidine; ophthalmic
14.1
59.5
103
75
Z3231
NOMESCO Finland
Registered nurse
2.0
58.8
981
5780
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
54.3
52
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
54.3
52
*
H57.1
ICD-10 Finland
Ocular pain
5.6
53.4
162
301
S01BC03
ATC
diclofenac; ophthalmic
6.5
53.3
143
227
XCK00
NOMESCO Finland
Perimetry
3.2
53.0
298
984
114
Kela drug reimbursment
Glaucoma
2.9
51.7
351
1318
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
48.7
468
2136
S01EE01
ATC
latanoprost; ophthalmic
3.3
48.3
258
820
H16.8
ICD-10 Finland
Other keratitis
75.6
46.1
52
7
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
45.9
44
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
45.4
1270
8745
E85.80
ICD-10 Finland
Meretoja sick
453.8
45.4
45
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
43.8
42
*
ZXE00
NOMESCO Finland
One hour or less
1.7
43.4
1285
8962
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.2
43.2
107
152
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.2
42.6
236
770
H26.2
ICD-10 Finland
Complicated cataract
9.0
42.1
91
104
37103
ICD-8 Finland
Corneal opacity, Keratoconus
+∞
41.7
40
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
49.7
40.8
49
10
S01FA01
ATC
atropine; ophthalmic
27.1
40.7
56
21
S01AX11
ATC
[U] ofloxacin; ophthalmic
4.0
40.6
168
432
3619
FHL
Other operations in this group, such as corneal refractive surgery
207.5
39.9
41
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
8.6
39.3
87
104
ZXD20
NOMESCO Finland
Day surgery
2.2
39.0
467
2346
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
87.2
38.9
43
5
H26.02
ICD-10 Finland
Presenil cataract
4.4
37.6
140
326
S01EC04
ATC
brinzolamide; ophthalmic
3.9
37.4
160
424
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.0
37.3
227
789
H40.0
ICD-10 Finland
Glaucoma suspect
2.6
37.1
287
1156
XCH00
NOMESCO Finland
Eye pressure measurement
3.6
36.9
177
517
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
36.1
653
3852
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
35.5
34
*
S01XA18
ATC
ciclosporin; ophthalmic
16.1
35.1
57
36
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
43.5
35.0
43
10
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
5.3
34.6
108
208
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
57.8
34.2
40
7
CD2S4
NOMESCO Finland
Photography of eye
16.8
33.2
53
32
H33.0
ICD-10 Finland
Retinal detachment with retinal break
4.4
33.1
123
286
H27.0
ICD-10 Finland
Aphakia
24.7
31.4
44
18
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.0
31.3
67
76
S01EE05
ATC
tafluprost; ophthalmic
3.7
31.1
141
393
CGF10
NOMESCO Finland
Suture of laceration of cornea
33.7
30.9
40
12
CFD10
NOMESCO Finland
Repair of conjunctiva
111.1
30.7
33
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
3.0
30.5
182
625
S01EX03
ATC
NA
4.8
29.9
103
222
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
29.9
1135
8229
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
15.7
29.4
48
31
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
18.2
29.2
45
25
H25.8
ICD-10 Finland
Other senile cataract
2.1
28.2
338
1688
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
28.2
27
*
S01AA12
ATC
tobramycin; ophthalmic
19.3
27.8
42
22
S01FA04
ATC
cyclopentolate; ophthalmic
9.8
27.1
55
57
WX142
NOMESCO Finland
Sub-tenon anesthesy
14.2
26.6
45
32
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
3.8
26.1
112
299
S01EC03
ATC
dorzolamide; ophthalmic
5.3
25.7
80
155
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
136.1
25.6
27
*
CKD60
NOMESCO Finland
Anterior vitrectomy
7.6
24.8
58
77
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.6
24.5
181
710
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.4
24.3
74
140
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
24.0
23
*
Z2221
NOMESCO Finland
Medical doctor
1.6
23.9
853
6023
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
67.9
23.8
27
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
241.6
23.7
24
*
S01KA02
ATC
hypromellose; ophthalmic
4.1
23.6
94
235
S01BC05
ATC
ketorolac; ophthalmic
2.9
23.2
145
514
H15.1
ICD-10 Finland
Episcleritis
14.8
22.9
38
26
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
26.1
22.6
31
12
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
7.2
22.6
55
78
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.0
21.8
89
228
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
21.6
195
853
F29
ICPC
Eye symptom/complaint other
2.1
21.6
253
1247
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
115.8
21.6
23
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
115.8
21.6
23
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
43.6
21.4
26
6
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.7
21.3
61
108
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.1
21.0
119
394
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
20.8
20
*
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
20.8
20
*
L04AA01
ATC
[U] ciclosporin; systemic
4.5
20.6
73
164
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
19.8
19
*
3606
FHL
Keratophakic corneal surgery
+∞
19.8
19
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
19.7
1084
8334
H10.4
ICD-10 Finland
Chronic conjunctivitis
6.5
19.6
51
80
H16.3
ICD-10 Finland
Interstitial and deep keratitis
201.1
19.6
20
*
WX110
NOMESCO Finland
Local anesthesy
1.4
19.5
2044
17692
H02AB06
ATC
prednisolone; systemic
1.4
19.3
1353
10885
H54.4
ICD-10 Finland
Blindness, monocular
16.8
19.1
30
18
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.6
19.1
145
580
S01EB01
ATC
pilocarpine; ophthalmic
6.9
18.9
47
69
S01EE04
ATC
travoprost; ophthalmic
3.5
18.9
89
259
H52.1
ICD-10 Finland
Myopia
3.1
18.6
102
333
H3603, E103
ICD-10 Finland
NA
5.6
18.5
54
98
S01ED02
ATC
betaxolol; ophthalmic
5.3
18.3
56
108
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
11.9
18.3
33
28
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.9
18.2
112
394
S01FA02
ATC
scopolamine; ophthalmic
8.6
18.1
39
46
CHD99
NOMESCO Finland
Other filtering operation
13.7
17.7
30
22
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
24.1
17.3
24
10
H40.9
ICD-10 Finland
Glaucoma, unspecified
4.0
17.2
69
176
CBH30
NOMESCO Finland
Tarsorraphy
50.3
17.0
20
*
H01.0
ICD-10 Finland
Blepharitis
2.3
17.0
163
734
D07AA02
ATC
hydrocortisone; topical
1.7
16.8
388
2421
H21.0
ICD-10 Finland
Hyphaema
90.5
16.6
18
*
S01EE03
ATC
bimatoprost; ophthalmic
3.2
16.4
87
278
A10AA01
ATC
NA
2.9
16.3
99
345
S01EA02
ATC
dipivefrine; ophthalmic
9.8
16.1
32
33
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
30.2
16.1
21
7
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
24.6
16.0
22
9
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
6.4
15.8
41
65
J01DB01
ATC
cefalexin; oral
1.4
15.7
2487
22626
J05AB11
ATC
valaciclovir; oral
1.7
15.7
367
2298
3710A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal scars and opacities
+∞
15.6
15
*
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
15.6
15
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
85.5
15.6
17
*
H17.0
ICD-10 Finland
Adherent leukoma
160.7
15.5
16
*
H27.1
ICD-10 Finland
Dislocation of lens
10.8
15.4
29
27
F01
ICPC
Eye pain
3.0
15.2
89
305
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
15.2
779
5851
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.5
14.9
119
490
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.9
14.9
88
304
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
9.2
14.7
30
33
9881
FHL
Bandage replacement, suture or spike removal, or the like in an operating room or anesthesia
21.1
14.6
21
10
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
+∞
14.6
14
*
3715A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Hereditary corneal dystrophies
+∞
14.6
14
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
14.6
14
*
J05AB01
ATC
aciclovir; systemic
1.5
14.6
575
4092
N02BE01
ATC
paracetamol; systemic, rectal
1.4
14.3
2625
24232
H54.1
ICD-10 Finland
Severe visual impairment, binocular
17.0
14.3
22
13
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.9
14.3
87
304
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.0
14.1
83
286
L20.0
ICD-10 Finland
Besnier prurigo
2.0
14.0
180
922
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.1
13.9
77
255
A10AA02
ATC
NA
2.5
13.9
110
453
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
4.7
13.8
46
99
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
4.2
13.7
51
122
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
75.4
13.6
15
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
3.9
13.6
55
143
37102
ICD-8 Finland
Corneal opacity, Dystrophia corneae hereditaria
+∞
13.5
13
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.7
13.4
92
349
CKD20
NOMESCO Finland
Removal of vitreous body substitute
7.8
13.3
30
39
L04AD01
ATC
ciclosporin; systemic
3.4
13.2
63
188
E000001
ATC
NA
1.5
13.1
561
4053
E0000UV
ATC
NA
1.3
13.0
1105
9001
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
13.0
176
920
H11.0
ICD-10 Finland
Pterygium
5.8
13.0
36
63
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
22.6
12.9
18
8
H15.0
ICD-10 Finland
Scleritis
50.2
12.8
15
*
D11AH01
ATC
tacrolimus; topical
5.0
12.7
40
81
H20.8
ICD-10 Finland
Other iridocyclitis
70.1
12.6
14
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
12.5
12
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
12.5
1302
10921
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
130.5
12.4
13
*
B00.5
ICD-10 Finland
Herpesviral ocular disease
13.2
12.4
21
16
S01AX12
ATC
[U] norfloxacin; ophthalmic
7.1
12.3
29
41
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
10.5
12.2
23
22
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.0
12.2
151
765
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
4.1
12.2
46
113
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
15.9
12.1
19
12
127
Kela drug reimbursment
Transplant complication
3.5
12.0
55
160
Z97.0
ICD-10 Finland
Presence of artificial eye
46.8
11.9
14
*
3643
FHL
Vitrectomy through pars Plana
23.0
11.6
16
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
11.5
889
7111
3661A
ICD-9 Finland
Cataract, Senile cataract
4.7
11.5
38
82
M79.6
ICD-10 Finland
Pain in limb
1.3
11.5
958
7753
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.5
11.4
39
87
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.4
11.3
96
411
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
10.6
11.2
21
20
R03AC02
ATC
salbutamol; inhalant
1.3
11.2
1473
12693
H02.4
ICD-10 Finland
Ptosis of eyelid
2.6
11.2
82
325
S01XA02
ATC
retinol; ophthalmic
5.7
11.1
31
55
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
25.1
11.1
15
6
CS494
NOMESCO Finland
Other visual field testing
2.8
10.9
68
244
CHC05
NOMESCO Finland
Iridotomy
3.2
10.9
56
178
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
3.2
10.6
53
165
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
60.2
10.6
12
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.7
10.6
228
1393
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.8
10.5
67
245
CBB30
NOMESCO Finland
Excision of lesion of eyelid
2.4
10.5
85
357
S18
ICPC
Laceration/cut
1.3
10.5
1138
9537
D07AB08
ATC
desonide; topical
1.6
10.4
291
1906
H19.8
ICD-10 Finland
Other disorders of sclera and cornea in diseases classified elsewhere
110.3
10.4
11
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
10.4
10
*
CGD00
NOMESCO Finland
Keratotomy for error of refraction
+∞
10.4
10
*
SPAT1009
SPAT
Measurement of intraocular pressure
3.4
10.4
48
141
CKD40
NOMESCO Finland
Endophotocoagulation of retina
3.6
10.4
45
126
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
2.9
10.3
60
207
H02AB04
ATC
methylprednisolone; systemic
1.5
10.3
388
2720
CKD15
NOMESCO Finland
Injection of vitreous substitute
7.1
10.3
24
34
H44.5
ICD-10 Finland
Degenerated conditions of globe
18.8
10.2
15
8
UJF32
NOMESCO Finland
Coloscopy
1.4
10.2
677
5271
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
23.4
10.2
14
6
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
1.9
10.2
152
826
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
10.2
726
5715
XCH05
NOMESCO Finland
Eye pressure longterm registration
4.0
10.2
39
98
S01GX08
ATC
ketotifen; ophthalmic
2.2
10.1
101
468
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
2.7
10.1
68
258
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4.5
10.0
34
76
J01FF01
ATC
clindamycin; systemic
1.3
10.0
734
5802
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
10.0
1570
13764
37403
ICD-8 Finland
Cataract, Complicata
40.2
10.0
12
*
D11AX14
ATC
[U] tacrolimus; topical
5.8
9.9
27
47
R51.80
ICD-10 Finland
Headache
1.5
9.8
371
2604
C03CA01
ATC
furosemide; systemic
1.3
9.8
696
5469
37404
ICD-8 Finland
Cataract, Secundaria
26.1
9.8
13
5
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
26.1
9.8
13
5
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
5.4
9.8
28
52
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.8
9.8
61
219
CFW99
NOMESCO Finland
Other operation on conjunctiva
8.7
9.8
20
23
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
9.7
196
1175
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
4.3
9.7
34
79
N02AX02
ATC
tramadol; systemic, rectal
1.3
9.6
1154
9765
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
5.0
9.5
29
58
H54.0
ICD-10 Finland
Blindness, binocular
15.1
9.5
15
10
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
9.5
763
6115
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
9.4
646
5050
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
100.3
9.4
10
*
QAJ20
NOMESCO Finland
Subperiosteal facelift
100.3
9.4
10
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.0
9.4
121
623
CBH25
NOMESCO Finland
Tarsorrhaphy
30.1
9.4
12
*
R3120
NOMESCO Finland
Training in mobility skills
17.6
9.4
14
8
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
17.6
9.4
14
8
36300
ICD-8 Finland
Keratitis, Ulcerosa
+∞
9.4
9
*
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
9.4
9
*
3656F
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POST UVEITIDEM]
+∞
9.4
9
*
A10AE04
ATC
insulin glargine; parenteral
1.6
9.4
246
1587
S01GX05
ATC
lodoxamide; ophthalmic
3.1
9.3
50
165
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.6
9.3
64
246
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
9.3
186
1113
H35.36
ICD-10 Finland
Macular cyst
5.6
9.3
26
47
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
9.2
1314
11341
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
4.5
9.2
31
69
A98
ICPC
Health maint/preventive medicine
1.5
9.2
3033
29214
D07AC01
ATC
betamethasone; topical
1.3
9.2
913
7530
-1
NOMESCO Finland
NA
1.3
9.1
867
7099
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
4.3
9.1
32
75
H04AA01
ATC
glucagon; nasal, parenteral
2.5
9.0
69
282
T89
ICPC
Diabetes insulin dependent
2.0
9.0
108
544
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.3
8.9
78
342
M25.5
ICD-10 Finland
Pain in joint
1.3
8.9
741
5953
H44.2
ICD-10 Finland
Degenerative myopia
18.6
8.9
13
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
8.9
1149
9793
A02BC02
ATC
pantoprazole; systemic
1.2
8.8
1827
16456
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.7
1970
17898
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
3.0
8.7
48
162
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.4
8.7
30
69
CFB00
NOMESCO Finland
Suture of conjunctiva
14.1
8.7
14
10
H20
ICD-10 Finland
Iridocyclitis
14.1
8.7
14
10
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
50.1
8.7
10
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
50.1
8.7
10
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
50.1
8.7
10
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
8.7
720
5781
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
3.5
8.6
38
109
J01AA02
ATC
doxycycline; systemic
1.3
8.6
2299
21291
D11AH02
ATC
pimecrolimus; topical
6.9
8.5
20
29
H33.4
ICD-10 Finland
Traction detachment of retina
10.0
8.5
16
16
H10.5
ICD-10 Finland
Blepharoconjunctivitis
2.9
8.5
50
176
H10
ICD-10 Finland
Conjunctivitis
1.8
8.5
147
845
3708
FHL
Trabeculectomy or equivalent
20.1
8.5
12
6
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
20.1
8.5
12
6
N03AX16
ATC
pregabalin; oral
1.3
8.5
616
4852
F99
ICPC
Eye/adnexa disease other
5.4
8.4
24
45
3719
FHL
Other measure in this category
90.3
8.4
9
*
3705A
ICD-9 Finland
Keratitis, Interstitial and deep keratitis
+∞
8.3
8
*
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
+∞
8.3
8
*
CGF20
NOMESCO Finland
Suture of laceration of cornea with plastic repair of conjunctiva
+∞
8.3
8
*
37108
ICD-8 Finland
Corneal opacity, Alia definita
+∞
8.3
8
*
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
8.3
8
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
6.2
8.3
21
34
A10AE06
ATC
insulin degludec; parenteral
2.2
8.3
79
362
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
8.3
1166
10017
ZXD05
NOMESCO Finland
Urgent procedure
1.3
8.3
813
6679
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
14.5
8.2
13
9
F05
ICPC
Visual disturbance other
2.3
8.2
73
325
CKC12
NOMESCO Finland
Photocoagulation of retina
1.9
8.2
110
582
3852
FHL
Reoperation for another reason
33.4
8.1
10
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.7
8.1
172
1050
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
6.8
8.1
19
28
CJF20
NOMESCO Finland
Removal of artificial lens
22.1
8.0
11
5
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.6
8.0
188
1180
D07AC13
ATC
mometasone; topical
1.3
8.0
768
6287
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.9
8.0
47
166
H02.2
ICD-10 Finland
Lagophthalmos
5.3
8.0
23
44
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
4.1
8.0
29
71
R4110
NOMESCO Finland
Physiotherapy
1.3
8.0
703
5689
R06AE09
ATC
levocetirizine; oral
1.4
7.8
360
2625
H02.1
ICD-10 Finland
Ectropion of eyelid
3.4
7.8
35
103
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.7
7.7
32
88
A02BC05
ATC
esomeprazole; systemic
1.2
7.7
1087
9318
CDC00
NOMESCO Finland
Enucleation of eye
45.1
7.7
9
*
37520
ICD-8 Finland
Glaucoma, Secondary
15.0
7.7
12
8
E10
ICD-10 Finland
Type 1 diabetes mellitus
2.5
7.7
58
238
CKC10
NOMESCO Finland
Local photocoagulation of retina
2.6
7.7
53
205
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.4
7.7
331
2384
C08CA01
ATC
amlodipine; oral
1.3
7.6
904
7591
G47.3
ICD-10 Finland
Sleep apnoea
1.3
7.6
528
4122
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.5
7.6
293
2063
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.6
1023
8720
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.6
7.6
179
1126
H3603, E113
ICD-10 Finland
NA
4.0
7.6
28
70
J01FA10
ATC
azithromycin; systemic
1.2
7.5
1602
14355
D02AE01
ATC
carbamide; topical
1.6
7.5
172
1073
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
5.1
7.5
22
43
M01AH05
ATC
etoricoxib; oral
1.2
7.5
1623
14566
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
5.7
7.5
20
35
R06AX13
ATC
loratadine; oral
1.4
7.5
387
2879
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.5
7.5
230
1545
R42
ICD-10 Finland
Dizziness and giddiness
1.3
7.5
544
4279
S01EC54
ATC
brinzolamide, combinations; ophthalmic
3.1
7.5
38
123
CGA00
NOMESCO Finland
Biopsy of cornea
80.3
7.4
8
*
R06AE07
ATC
cetirizine; oral
1.2
7.4
1170
10153
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2.1
7.3
77
369
N05BB01
ATC
hydroxyzine; systemic
1.7
7.3
160
985
36309
ICD-8 Finland
Keratitis, Ulcus corneae NUD
+∞
7.3
7
*
CDW99
NOMESCO Finland
Other operation on eyeball
+∞
7.3
7
*
3712A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal oedema
+∞
7.3
7
*
T85.3
ICD-10 Finland
Mechanical complication of other ocular prosthetic devices, implants and grafts
+∞
7.3
7
*
R01AD08
ATC
fluticasone; nasal
1.3
7.3
743
6120
H54.7
ICD-10 Finland
Unspecified visual loss
4.0
7.3
27
68
S01GX09
ATC
olopatadine; ophthalmic
2.2
7.2
66
297
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
4.3
7.2
25
59
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
2.3
7.2
60
258
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
7.2
535
4222
286
Kela drug reimbursment
Ciclosporin eye drop
30.1
7.1
9
*
37401
ICD-8 Finland
Cataract, Praesenilis
30.1
7.1
9
*
R01AD09
ATC
mometasone; nasal
1.2
7.1
1198
10446
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
7.1
428
3264
F28
ICPC
Limited function/disability (F)
4.8
7.1
22
46
CWD00
NOMESCO Finland
Reoperation for superficial heamorrhage in eye and adjacent structures
20.0
7.1
10
5
05405
ICD-8 Finland
Herpes simplex, Kerato-conjunctivitis herpetica
20.0
7.1
10
5
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
7.1
339
2488
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
7.1
906
7665
F03
ICPC
Eye discharge
1.7
7.1
139
832
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
8.8
7.0
14
16
D11AX15
ATC
[U] pimecrolimus; topical
8.8
7.0
14
16
M03BX02
ATC
tizanidine; oral
1.2
7.0
1736
15754
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.1
7.0
79
390
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
7.0
7.0
16
23
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.3
6.9
762
6330
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.9
431
3309
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
7.5
6.9
15
20
CJF15
NOMESCO Finland
Secondary implantation of skleral fixed artificial lens in posterior chamber
13.8
6.9
11
8
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.8
1368
12136
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.2
6.8
943
8045
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.8
1557
13995
H40.8
ICD-10 Finland
Other glaucoma
6.7
6.8
16
24
M79.0
ICD-10 Finland
Rheumatism, unspecified
1.9
6.8
88
460
3747
FHL
Combined ablation and vitreous surgery with coagulation
40.1
6.8
8
*
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.6
6.7
149
925
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
7.2
6.7
15
21
A46
ICD-10 Finland
Erysipelas
1.4
6.7
336
2488
H44.0
ICD-10 Finland
Purulent endophthalmitis
22.5
6.7
9
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
22.5
6.7
9
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.4
6.6
271
1930
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.6
615
4997
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.4
6.5
330
2445
J01CA04
ATC
amoxicillin; systemic
1.2
6.5
2341
21970
CF2S4
NOMESCO Finland
Photography of conjunctiva
10.0
6.5
12
12
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
1.9
6.5
92
495
E000002
ATC
NA
1.4
6.5
273
1961
ZXC20
NOMESCO Finland
Use of chemical agents
2.3
6.5
56
248
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.5
6.5
238
1664
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
6.2
6.5
16
26
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
6.4
1744
15904
H18
ICD-10 Finland
Other disorders of cornea
70.0
6.4
7
*
S01EX05
ATC
netarsudil; ophthalmic
70.0
6.4
7
*
H17
ICD-10 Finland
Corneal scars and opacities
70.0
6.4
7
*
Z96.7
ICD-10 Finland
Presence of other bone and tendon implants
70.0
6.4
7
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
6.4
588
4771
E000003
ATC
NA
1.7
6.4
112
650
Q12.0
ICD-10 Finland
Congenital cataract
14.3
6.4
10
7
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
3.8
6.4
25
67
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
6.3
602
4906
M01AB05
ATC
diclofenac; systemic, rectal
1.2
6.3
1879
17271
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
6.3
1058
9195
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.3
1488
13382
CBH40
NOMESCO Finland
Division of tarsorrhaphy
+∞
6.2
6
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
6.2
6
*
3719X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Unspecified corneal disorder
+∞
6.2
6
*
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
+∞
6.2
6
*
3659
FHL
Other measure in this category
+∞
6.2
6
*
CWW99
NOMESCO Finland
Other reoperation on eye and adjacent structures
26.7
6.2
8
*
CHD10
NOMESCO Finland
Trabeculectomy
26.7
6.2
8
*
H54.5
ICD-10 Finland
Severe visual impairment, monocular
4.8
6.2
19
40
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
6.2
504
4019
R03BA05
ATC
fluticasone; inhalant
1.3
6.2
456
3588
R53
ICD-10 Finland
Malaise and fatigue
1.3
6.1
497
3970
E66.8
ICD-10 Finland
Other obesity
1.7
6.0
121
731
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
10.0
6.0
11
11
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
10.0
6.0
11
11
R5140
NOMESCO Finland
Monitoring the use of the aid
1.4
6.0
246
1755
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOTH | 1.079 [0.97, 1.2] | 0.167 |
| Birth year | 0.994 [0.99, 1.0] | 0.158 |
During the follow-up period (1.1.1998 — 31.12.2019), 1796 out of 10978 females with H7_CORNEALOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOTH | 1.064 [0.93, 1.21] | 0.35 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1173 out of 10027 males with H7_CORNEALOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.197% |
| 5 | 0.575% | 1.265% |
| 10 | 1.581% | 3.053% |
| 15 | 3.064% | 5.747% |
| 20 | 5.477% | 9.251% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOTH – Other disorders of cornea
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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