Hereditary corneal dystrophies

H7_KERATOCONUS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H18.5
  • Hospital discharge: ICD-9 3715
  • Hospital discharge: ICD-8 37102
  • Cause of death: ICD-10 H18.5
  • Cause of death: ICD-9 3715
  • Cause of death: ICD-8 37102

2 out of 7 registries used, show all original rules.

1226

4. Check minimum number of events

None

1226

5. Include endpoints

None

1226

6. Filter based on genotype QC (FinnGen only)

1196

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Dystrophia corneae hereditaria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6239 4234 1985
Only index persons 5832 3982 1850
Unadjusted period prevalence (%)
Whole population 0.10 0.12 0.06
Only index persons 0.12 0.15 0.07
Median age at first event (years)
Whole population 66.92 68.44 63.65
Only index persons 66.40 67.91 63.14

-FinnGen-

Key figures

All Female Male
Number of individuals 1196 816 380
Unadjusted period prevalence (%) 0.25 0.29 0.17
Median age at first event (years) 66.63 65.89 68.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1226
Matched controls
12260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TCG10
NOMESCO Finland
Removal of sutures from cornea
178.6
317.6
156
10
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
4503599627370496.0
307.7
1217
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
268.2
307.7
238
11
CG2T4
NOMESCO Finland
Topography assessment of cornea
342.7
307.7
268
10
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
276.9
255
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.2
251.8
542
1217
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.8
224.7
484
1073
H16.0
ICD-10 Finland
Corneal ulcer
26.5
223.4
158
68
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
207.3
193
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.9
196.5
385
768
H18.4
ICD-10 Finland
Corneal degeneration
472.1
169.0
165
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.4
159.1
917
4340
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.8
155.8
780
3299
CG2S4
NOMESCO Finland
Photography of cornea
346.2
152.4
151
5
WX140
NOMESCO Finland
Parabulbar anesthesy
7.9
131.2
197
290
H18.8
ICD-10 Finland
Other specified disorders of cornea
1145.9
109.2
105
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.5
103.8
627
2795
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
92.9
88
*
H18.6
ICD-10 Finland
Keratoconus
+∞
92.9
88
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.4
89.7
269
738
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.2
78.3
242
675
ZXA10
NOMESCO Finland
Bilateral
3.3
76.6
398
1564
H26.4
ICD-10 Finland
After-cataract
3.9
76.3
271
834
XCK10
NOMESCO Finland
Photography of fundus of eye
4.1
73.9
238
682
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
751.2
72.9
71
*
H18.1
ICD-10 Finland
Bullous keratopathy
728.7
70.8
69
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
14.3
69.4
64
47
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
90.0
68.8
76
9
WX002
NOMESCO Finland
Sedation and analgesia
3.1
67.8
400
1676
H16.9
ICD-10 Finland
Keratitis, unspecified
102.8
62.5
68
7
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
62.0
59
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
573.2
56.1
55
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
105.1
55.3
60
6
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
54.0
190
573
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
52.6
227
780
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.5
51.3
581
3284
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
47.2
45
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
47.2
45
*
S01AD03
ATC
aciclovir; ophthalmic
6.1
46.9
85
149
S01ED01
ATC
timolol; ophthalmic
5.4
46.1
95
188
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
124.8
45.1
48
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
44.0
42
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.0
42.2
43
37
CGE10
NOMESCO Finland
Keratectomy
+∞
40.9
39
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
39.8
38
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
15.0
39.2
35
24
S01EA03
ATC
apraclonidine; ophthalmic
11.8
38.8
40
35
H52.2
ICD-10 Finland
Astigmatism
7.6
38.8
56
77
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.7
38.7
131
382
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
34.5
33
*
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
33.5
32
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.3
32.9
132
429
Z3231
NOMESCO Finland
Registered nurse
2.1
31.8
411
2345
ZXA05
NOMESCO Finland
Left side
2.1
31.4
404
2299
ZXA00
NOMESCO Finland
Right side
2.1
30.7
426
2490
ZXE00
NOMESCO Finland
One hour or less
2.0
30.4
546
3503
S01ED51
ATC
timolol, combinations; ophthalmic
3.0
30.3
150
551
H17.8
ICD-10 Finland
Other corneal scars and opacities
298.8
28.9
29
*
S01XA18
ATC
ciclosporin; ophthalmic
11.0
27.9
30
28
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
27.2
26
*
H25.8
ICD-10 Finland
Other senile cataract
2.4
27.0
205
932
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
276.9
26.8
27
*
CHC05
NOMESCO Finland
Iridotomy
6.5
26.7
44
70
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
26.1
25
*
CGD99
NOMESCO Finland
Other operation for error of refraction
266.0
25.8
26
*
S01EA05
ATC
brimonidine; ophthalmic
4.8
25.4
59
129
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
24.5
265
1394
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
24.0
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
23.5
524
3525
S01BA04
ATC
prednisolone; ophthalmic
5.7
23.3
44
80
XCH00
NOMESCO Finland
Eye pressure measurement
3.3
22.2
88
283
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
20.9
20
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
19.8
19
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
19.6
487
3337
Z2221
NOMESCO Finland
Medical doctor
1.8
19.5
368
2321
CKD60
NOMESCO Finland
Anterior vitrectomy
7.6
19.1
27
36
CGF10
NOMESCO Finland
Suture of laceration of cornea
96.5
17.6
19
*
S01EC01
ATC
acetazolamide; systemic
4.7
17.1
40
88
S01AA01
ATC
chloramphenicol; ophthalmic
3.0
17.0
79
279
XCK00
NOMESCO Finland
Perimetry
2.6
16.8
103
420
H57.1
ICD-10 Finland
Ocular pain
3.6
16.2
54
155
S01EE05
ATC
tafluprost; ophthalmic
3.0
15.3
70
245
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
15.1
174
925
H18.7
ICD-10 Finland
Other corneal deformities
+∞
14.6
14
*
3715A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Hereditary corneal dystrophies
+∞
14.6
14
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.2
14.1
125
601
CD2S4
NOMESCO Finland
Photography of eye
10.6
13.8
26
25
3604
FHL
Penetration of the cornea
+∞
13.6
13
*
37102
ICD-8 Finland
Corneal opacity, Dystrophia corneae hereditaria
+∞
13.6
13
*
ZXD20
NOMESCO Finland
Day surgery
1.9
13.5
177
983
S01GX01
ATC
cromoglicic acid; ophthalmic
1.8
13.3
242
1488
H26.02
ICD-10 Finland
Presenil cataract
3.4
13.0
47
143
S01EE01
ATC
latanoprost; ophthalmic
2.3
12.9
103
474
S01BA07
ATC
fluorometholone; ophthalmic
4.9
12.9
28
58
H16.8
ICD-10 Finland
Other keratitis
70.6
12.6
14
*
H02.1
ICD-10 Finland
Ectropion of eyelid
5.9
12.3
22
38
H26.2
ICD-10 Finland
Complicated cataract
5.0
12.2
26
53
S01BC03
ATC
diclofenac; ophthalmic
3.6
12.2
40
114
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.4
11.8
83
361
S01BA01
ATC
dexamethasone; ophthalmic
3.0
11.7
52
179
S01ED02
ATC
betaxolol; ophthalmic
5.0
11.7
25
51
S01FA01
ATC
atropine; ophthalmic
16.6
11.7
18
11
H16.2
ICD-10 Finland
Keratoconjunctivitis
65.6
11.6
13
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.2
11.5
104
503
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
11.5
11
*
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
11.5
11
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
11.5
11
*
S01AX11
ATC
[U] ofloxacin
2.8
11.3
55
199
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
8.4
11.3
24
29
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.7
11.1
60
230
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
110.9
10.4
11
*
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
10.4
10
*
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
10.4
10
*
114
Kela drug reimbursment
Glaucoma
1.9
10.1
128
700
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
4.0
10.1
28
71
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
100.8
9.4
10
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
17.7
9.4
14
8
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
9.4
9
*
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
9.4
9
*
H19.8
ICD-10 Finland
Other disorders of sclera and cornea in diseases classified elsewhere
+∞
9.4
9
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.2
9.4
19
37
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.1
9.3
90
448
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.3
472
3663
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
9.2
814
7012
S01KA02
ATC
hypromellose; ophthalmic
3.2
9.2
35
110
S01EC54
ATC
brinzolamide, combinations; ophthalmic
4.2
8.9
23
55
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
3.8
8.9
27
73
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.6
8.8
51
203
A98
ICPC
Health maint/preventive medicine
2.3
8.7
1172
11077
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
3.9
8.7
25
65
QAJ10
NOMESCO Finland
Browlift
16.4
8.6
13
8
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
27.7
8.5
11
*
S01BC05
ATC
ketorolac; ophthalmic
2.4
8.5
57
244
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
8.3
8
*
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
8.3
8
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
8.3
8
*
E0000UV, ,
ATC
1.4
8.3
475
3751
H52.1
ICD-10 Finland
Myopia
2.8
8.2
40
146
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.1
8.1
71
341
S01EE04
ATC
travoprost; ophthalmic
3.0
7.8
33
111
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
10.9
7.8
14
13
H02.2
ICD-10 Finland
Lagophthalmos
9.5
7.8
15
16
R06AX13
ATC
loratadine; oral
1.7
7.7
166
1060
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
45.3
7.7
9
*
D22
ICD-10 Finland
Melanocytic naevi
2.4
7.7
53
230
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.1
7.6
70
342
H27.0
ICD-10 Finland
Aphakia
11.9
7.6
13
11
CFD10
NOMESCO Finland
Repair of conjunctiva
25.2
7.6
10
*
F01
ICPC
Eye pain
2.9
7.4
33
115
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
7.3
7
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
7.3
7
*
H21.0
ICD-10 Finland
Hyphaema
+∞
7.3
7
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
7.3
7
*
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4.5
7.2
17
38
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
20.1
7.1
10
5
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
8.0
7.1
15
19
S01EC04
ATC
brinzolamide; ophthalmic
2.2
7.1
59
277
XCH05
NOMESCO Finland
Eye pressure longterm registration
4.2
7.0
18
43
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
3.7
6.9
21
57
D07AA02
ATC
hydrocortisone; topical
1.7
6.9
146
928
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.6
6.9
39
154
Z01.2
ICD-10 Finland
Dental examination
1.4
6.9
483
3918
QAJ30
NOMESCO Finland
Other facelift
11.0
6.8
12
11
QAJ15
NOMESCO Finland
Browlift using video-endoscope
40.3
6.8
8
*
J01DB01
ATC
cefalexin; oral
1.4
6.4
952
8670
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
70.2
6.4
7
*
H02.3
ICD-10 Finland
Blepharochalasis
1.8
6.3
88
497
S01EC03
ATC
dorzolamide; ophthalmic
3.6
6.3
20
56
R01AD08
ATC
fluticasone; nasal
1.4
6.3
305
2313
H15.1
ICD-10 Finland
Episcleritis
11.1
6.3
11
10
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
2.4
6.3
41
174
E85.8
ICD-10 Finland
Other amyloidosis
+∞
6.3
6
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
4.0
6.2
17
43
S01FA04
ATC
cyclopentolate; ophthalmic
6.3
6.2
15
24
D07AC13
ATC
mometasone; topical
1.4
6.1
323
2491
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.6
6.0
132
847

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
610
4334
1.81
22.59
2.5
2.2
—
—
—
0
0
1169
10762
2.85
14.43
19.0
17.9
3.96
3.97
mmol/l
0.61
1132
10459
1167
10738
2.80
14.36
18.8
17.8
139.74
139.65
mmol/l
0.60
1133
10454
580
4501
1.55
12.44
2.3
2.3
80.68
79.15
nmol/l
0.62
497
3969
1067
9584
1.87
12.29
5.5
5.1
1.93
2.08
mu/l
0.58
949
8657
637
5055
1.54
12.28
5.6
5.8
1.22
1.21
mmol/l
1.13
563
4578
901
7793
1.59
11.26
4.4
4.2
12.98
13.38
mm/h
0.35
807
7150
1113
10215
1.97
10.85
15.8
15.1
23.74
24.68
mg/l
0.38
894
8140
1127
10402
2.03
10.59
5.6
5.2
2.68
2.73
mmol/l
0.90
1012
9462
1166
10905
2.41
10.56
11.8
11.0
24.17
24.88
u/l
0.68
1113
10482
1107
10185
1.90
10.06
5.0
4.6
4.64
4.67
mmol/l
0.48
998
9308
672
5541
1.47
9.84
6.5
6.6
1.22
1.22
mmol/l
1.07
544
4696
188
1167
1.72
9.83
1.8
1.7
—
—
—
0
0
1188
11256
2.79
9.55
24.4
22.5
247.45
250.70
e9/l
0.99
1149
10944
1188
11257
2.79
9.53
24.3
22.5
6.66
6.68
e9/l
0.10
1144
10906
1188
11257
2.79
9.53
24.3
22.4
91.69
91.39
fl
1.58
1169
11072
1188
11259
2.78
9.49
24.4
22.5
4.41
4.42
e12/l
0.50
1144
10910
1188
11261
2.77
9.44
24.5
22.6
132.90
133.24
g/l
0.36
1168
11076
1187
11249
2.74
9.40
24.5
22.6
39.54
39.52
%
0.03
1119
10445
1187
11258
2.71
9.22
24.2
22.4
30.41
30.33
pg
0.90
1169
11072
430
3284
1.48
9.14
3.9
4.0
7.40
7.40
ph
0.28
81
622
1061
9697
1.70
9.12
6.5
6.1
40.18
40.06
mmol/mol
0.16
954
8887
1095
10103
1.78
8.99
5.0
4.6
1.51
1.51
mmol/l
0.01
978
9172
1098
10147
1.79
8.85
5.3
4.9
6.01
5.97
mmol/l
0.51
973
9125
570
4619
1.44
8.76
2.1
2.0
100.02
95.58
pmol/l
1.07
280
2288
1062
9759
1.66
8.31
4.4
4.1
1.29
1.28
mmol/l
0.13
937
8781
898
8052
1.43
6.98
4.6
4.2
14.91
14.96
pmol/l
0.23
792
7259
217
1531
1.51
6.55
2.5
2.4
2.31
2.33
g/l
0.15
200
1426
907
8195
1.41
6.37
7.7
7.7
77.93
79.24
u/l
0.46
838
7686
801
7097
1.37
6.28
5.0
4.8
458.29
2690.50
e6/l
—
7
106
958
8752
1.43
6.22
19.2
18.1
15.75
15.20
%
1.52
941
8599
1120
10580
1.68
6.10
15.6
14.5
—
—
—
0
0
346
2704
1.39
5.99
3.5
3.8
88.28
90.14
%
0.71
335
2636
470
3863
1.35
5.91
3.4
3.6
2.36
2.36
mmol/l
0.61
383
3367
203
1447
1.48
5.80
2.6
2.5
23.66
22.42
%
0.55
174
1242
362
2878
1.37
5.57
3.0
3.1
—
—
—
0
0
613
5280
1.32
5.45
6.2
5.6
2.07
1.89
e9/l
0.48
532
4637
245
1831
1.42
5.44
2.6
2.8
0.71
1.27
e6/l
3.85
140
1069
191
1367
1.47
5.33
1.4
1.3
—
—
—
0
0
812
7292
1.34
5.32
4.7
4.6
—
—
—
0
0
601
5175
1.32
5.30
6.1
5.5
0.04
0.04
e9/l
0.61
510
4437
229
1699
1.43
5.28
2.8
3.0
4.13
2.92
e6/l
0.70
128
945
566
4835
1.32
5.28
6.7
6.0
—
—
—
0
0
451
3737
1.33
5.20
3.7
3.8
71.63
104.78
e6/l
0.56
309
2680
599
5167
1.31
5.17
6.1
5.5
0.60
0.59
e9/l
0.70
509
4433
224
1670
1.42
5.01
2.6
2.4
13.64
12.81
umol/l
0.84
208
1560
614
5347
1.30
4.80
6.3
5.8
0.21
0.19
e9/l
1.71
528
4648
568
4912
1.29
4.63
6.2
5.6
57.60
57.63
%
0.02
526
4575
575
4987
1.29
4.55
6.4
5.8
27.23
27.38
%
0.11
535
4650
823
7478
1.31
4.53
4.5
4.0
—
—
—
0
0
158
1129
1.46
4.44
2.4
2.0
151.57
128.87
ug/g
0.31
120
895
563
4886
1.28
4.38
6.6
6.0
8.79
8.67
%
0.37
523
4546
362
2968
1.31
4.35
3.1
3.2
0.47
0.48
e6/l
0.02
272
2283
560
4862
1.28
4.32
6.4
5.7
3.16
2.80
%
2.56
519
4517
336
2729
1.32
4.32
2.4
2.2
2.89
3.08
mg/l
0.88
286
2298
178
1310
1.42
4.27
1.4
1.3
602.50
578.57
titre
0.06
48
293
590
5162
1.28
4.26
16.1
15.9
1.22
1.27
inr
0.88
164
1444
387
3212
1.30
4.23
3.2
3.3
20.25
79.79
e6/l
2.16
287
2487
172
1264
1.42
4.16
1.5
1.4
—
—
—
0
0
543
4721
1.27
4.07
6.5
5.7
0.69
0.67
%
0.40
505
4380
165
1214
1.41
3.96
1.4
1.3
—
—
—
0
0
61
361
1.73
3.85
1.2
1.2
—
1.41
—
0
21
404
3407
1.28
3.83
3.1
3.1
1631.21
1294.65
ng/l
0.56
329
2907
348
2886
1.29
3.76
1.7
1.7
1.35
1.35
mmol/l
0.04
292
2398
73
457
1.64
3.75
1.9
2.0
—
—
—
0
0
125
883
1.46
3.74
4.3
4.2
—
—
—
0
0
544
4778
1.25
3.59
4.8
4.6
35.45
35.25
g/l
0.36
484
4434
200
1546
1.35
3.56
1.3
1.2
—
—
—
0
0
632
5651
1.24
3.53
5.8
6.4
10.73
11.30
umol/l
0.98
581
5356
694
6270
1.25
3.53
4.6
4.7
6.65
6.74
mmol/l
0.65
651
5897
703
6366
1.24
3.48
3.3
3.2
43.87
51.25
u/l
2.08
640
5866
279
2274
1.29
3.41
1.7
1.8
1.38
1.30
mg/l
0.16
204
1756
259
2094
1.30
3.36
3.9
3.9
150.61
324.92
ng/l
2.18
215
1690
321
2691
1.26
3.10
1.6
1.5
23.22
21.11
nmol/l
1.36
254
2253
571
5099
1.22
3.08
4.0
3.9
0.00
0.00
estimate
0.75
121
1037
10
26
3.87
2.98
1.3
1.4
—
—
—
0
0
383
3297
1.24
2.90
4.7
4.1
—
—
—
0
0
489
4319
1.22
2.88
3.3
2.8
113.55
133.77
ug/l
1.75
442
3936
385
3319
1.23
2.87
3.6
3.3
599.30
317.19
mg/l
0.41
220
2020
122
903
1.39
2.86
3.4
3.4
89.75
85.36
ng/l
0.20
102
769
265
2194
1.27
2.83
2.8
3.0
2.48
2.46
mmol/l
1.72
224
1939
397
3441
1.23
2.80
3.5
3.1
6.71
6.94
mmol/l
0.52
323
2853
574
5166
1.21
2.76
4.0
4.0
0.00
0.01
estimate
0.80
109
944
78
538
1.48
2.69
1.3
1.2
—
—
—
0
0
218
1773
1.28
2.69
1.3
1.3
28.45
36.52
iu/ml
0.43
73
584
46
281
1.66
2.67
1.3
1.2
23.70
7.24
u/ml
—
6
50
261
2171
1.26
2.67
1.3
1.3
1.92
1.65
u/ml
0.13
70
563
259
2155
1.26
2.64
1.8
1.7
1054.36
1179.72
nmol/l
1.38
168
1589
417
3654
1.21
2.61
3.3
3.3
—
—
—
0
0
318
2713
1.23
2.58
2.5
2.7
3451.59
6812.43
umol/l
0.97
263
2332
150
1168
1.32
2.56
4.2
4.3
—
—
—
0
0
270
2268
1.24
2.53
2.5
2.6
4.36
6.29
e6/l
2.73
233
2049
70
479
1.49
2.53
1.2
1.2
—
—
—
0
0
401
3511
1.21
2.51
4.1
3.8
8.53
7.96
mg/mmol
0.10
229
2110
230
1899
1.26
2.50
1.3
1.5
2.49
2.46
g/l
0.07
135
1105
262
2196
1.25
2.50
2.9
2.9
517.44
532.86
mosm/kgh2o
0.52
216
1892
509
4561
1.20
2.49
11.6
9.7
0.00
0.00
e9/l
1.41
415
3703
103
760
1.39
2.49
2.0
2.9
10.49
10.57
g/l
0.08
94
691
210
1717
1.27
2.48
1.3
1.3
9.94
14.18
u/ml
0.29
57
616
565
5113
1.19
2.47
5.4
5.3
0.00
0.00
estimate
0.50
111
966
460
4086
1.20
2.47
3.3
3.6
6.14
5.80
ph
0.87
22
247
662
6082
1.19
2.43
8.8
9.0
4.00
4.09
e9/l
0.50
565
5301
469
4179
1.20
2.42
4.0
3.8
175.53
56.78
ng/l
0.48
348
3052
37
223
1.68
2.29
5.9
4.0
—
—
—
0
0
133
1037
1.32
2.27
1.4
1.4
—
—
—
0
0
92
678
1.39
2.26
2.3
2.5
13.46
24.70
au/ml
—
5
40
127
985
1.32
2.25
1.8
2.3
34.37
34.70
u/l
0.03
105
844
381
3353
1.20
2.22
2.1
2.1
147.81
231.33
u/l
2.35
338
3146
45
288
1.58
2.22
2.6
2.7
—
—
—
0
0
186
1526
1.26
2.14
2.3
2.0
—
—
—
0
0
179
1466
1.26
2.09
3.0
3.1
0.75
0.78
ug/l
0.16
138
995
282
2438
1.20
1.97
3.6
3.9
—
—
—
0
0
62
440
1.43
1.92
4.6
4.1
25.77
25.02
mmol/l
1.15
57
406
27
159
1.71
1.86
1.3
1.5
—
—
—
0
0
16
79
2.04
1.86
1.7
1.2
1.86
1.86
u/ml
—
8
41
32
198
1.63
1.85
3.0
2.7
3.91
4.29
e9/l
0.43
32
198
21
115
1.84
1.83
2.1
1.7
—
—
—
0
0
83
626
1.35
1.81
3.2
3.3
4.48
4.47
pmol/l
0.04
71
546
118
936
1.29
1.81
4.9
3.7
1.23
1.23
mmol/l
0.04
98
806
34
215
1.60
1.81
4.4
2.5
16.36
16.05
%
0.17
20
121
31
195
1.61
1.69
2.0
1.7
—
—
—
0
0
6
19
3.17
1.66
6.0
6.4
—
—
—
0
0
32
205
1.58
1.63
3.6
3.0
55.91
58.98
%
0.66
32
205
21
120
1.76
1.63
1.5
1.3
275.73
275.26
mosm/kgh2o
0.05
15
88
79
605
1.33
1.59
1.4
1.7
0.96
1.44
g/l
3.56
71
551
46
322
1.45
1.57
1.2
1.1
—
—
—
0
0
145
1207
1.23
1.50
1.6
1.6
—
—
—
0
0
28
178
1.59
1.49
1.2
1.2
122.82
33.23
u/l
0.51
21
155
289
2569
1.16
1.45
5.0
5.2
2.42
3.08
ug/l
0.53
255
2282
362
3276
1.15
1.42
2.8
3.2
30.72
32.46
u/l
0.25
335
3111
46
331
1.40
1.38
1.5
1.5
286.32
288.68
ug/g
0.03
29
200
331
2982
1.15
1.38
4.1
4.1
—
—
—
0
0
86
682
1.28
1.37
2.7
3.1
4.05
6.33
e9/l
1.35
59
535
116
954
1.24
1.36
2.8
2.1
392.39
375.58
nmol/l
0.35
105
871
300
2689
1.15
1.34
7.0
6.7
—
—
—
0
0
39
274
1.44
1.34
4.2
3.0
1.45
1.63
mg/l
0.61
34
250
149
1262
1.21
1.32
2.3
2.5
1.79
1.83
%
0.18
129
1127
46
335
1.39
1.31
3.0
3.1
—
—
—
0
0
90
725
1.26
1.28
3.5
3.2
—
—
—
0
0
66
511
1.31
1.27
1.4
1.8
1.47
1.54
g/l
0.30
60
440
56
424
1.34
1.26
1.4
2.7
10.74
10.26
g/l
0.40
49
379
87
700
1.26
1.25
4.6
3.7
5.37
5.17
kpa
1.19
81
670
109
902
1.23
1.23
1.5
1.5
—
—
—
0
0
86
693
1.26
1.23
4.6
3.6
7.40
7.40
ph
0.02
13
96
11
56
1.97
1.22
1.4
1.2
—
—
—
0
0
32
223
1.45
1.17
1.1
1.2
—
—
—
0
0
6
126
0.47
1.17
1.5
2.1
—
—
—
0
0
8
39
2.06
1.15
2.4
2.6
—
—
—
0
0
23
150
1.54
1.15
2.0
1.8
0.99
0.87
g/l
0.19
16
111
114
956
1.21
1.14
3.0
2.5
70.25
71.09
e9/l
0.09
82
743
97
800
1.23
1.14
1.5
2.6
—
—
—
0
0
138
1180
1.19
1.13
2.0
2.7
9.44
8.07
umol/l
0.16
118
1020
202
1786
1.16
1.10
2.9
3.3
0.82
0.81
mmol/l
0.22
190
1669
7
32
2.19
1.08
2.0
1.5
—
—
—
0
0
73
588
1.26
1.07
3.3
3.6
—
—
—
0
0
20
129
1.56
1.06
2.8
1.9
89.76
89.22
%
0.20
20
129
163
1424
1.17
1.04
6.1
5.1
1.01
1.03
mmol/l
0.52
147
1301
64
509
1.27
1.04
4.3
3.8
—
—
—
0
0
15
90
1.67
1.04
1.1
1.5
0.20
0.39
g/l
—
9
60
15
90
1.67
1.04
1.1
1.5
2.54
2.76
g/l
—
9
61
15
90
1.67
1.04
1.1
1.5
6.73
7.18
g/l
—
9
60
9
46
1.96
1.03
2.4
3.1
586.00
1437.76
u/ml
—
9
46
109
921
1.20
1.03
1.4
1.5
—
—
—
0
0
73
592
1.25
1.02
1.2
1.3
—
—
—
0
0
861
8321
1.12
1.01
21.1
20.0
330.96
331.41
g/l
0.78
854
8259
5
23
2.18
0.98
1.4
1.4
—
—
—
0
0
72
589
1.24
0.95
1.5
1.3
342.43
159.90
u/ml
0.87
64
532
47
365
1.30
0.94
1.4
2.5
38.78
37.51
g/l
0.89
40
322
15
93
1.62
0.94
1.1
1.5
—
—
—
0
0
90
757
1.20
0.91
1.2
1.2
—
—
—
0
0
6
29
2.07
0.89
1.3
1.8
71.17
93.90
nmol/24h
—
6
29
261
2384
1.12
0.88
1.7
1.7
48969533.33
24571864.44
pmol/l
0.20
194
1925
13
205
0.63
0.87
3.2
1.3
—
—
—
0
0
8
43
1.87
0.87
1.0
1.0
—
—
—
0
0
12
72
1.67
0.85
2.0
2.3
—
—
—
0
0
8
45
1.78
0.84
1.0
1.0
—
—
—
0
0
19
129
1.48
0.83
1.4
1.3
—
—
—
0
0
113
980
1.17
0.83
2.0
2.5
8.77
7.46
ug/l
0.17
94
861
124
1084
1.16
0.82
2.3
2.1
0.21
0.21
g/l
0.13
116
1027
8
48
1.67
0.79
1.3
1.3
153.13
165.66
mmol/24h
—
8
48
21
148
1.43
0.78
1.0
1.1
221.00
274.38
u/ml
0.35
13
85
0
27
0.00
0.77
0.0
1.4
—
—
—
0
0
34
261
1.31
0.77
1.5
1.7
3.07
5.07
iu/l
0.69
12
78
105
912
1.17
0.76
8.5
7.6
—
—
—
0
0
0
28
0.00
0.76
0.0
1.7
—
—
—
0
0
9
53
1.70
0.75
1.4
1.2
—
—
—
0
0
45
360
1.26
0.75
1.7
1.6
—
—
—
0
0
24
321
0.74
0.71
9.9
10.8
—
—
—
0
0
292
2718
1.10
0.70
4.0
3.6
—
—
—
0
0
18
127
1.42
0.68
1.2
1.2
—
50.26
—
0
8
31
241
1.29
0.66
3.6
2.2
131.64
127.98
g/l
0.34
22
180
5
28
1.79
0.66
1.0
1.0
—
—
—
0
0
34
270
1.27
0.63
2.3
2.2
99.00
94.14
ug/min
0.02
16
161
280
2619
1.09
0.61
2.2
2.3
—
—
—
0
0
70
602
1.17
0.61
2.7
2.5
—
—
—
0
0
109
970
1.14
0.60
2.4
3.1
205.40
193.09
ng/l
0.15
100
887
46
381
1.22
0.60
3.8
3.3
0.39
0.29
g/l
0.46
18
151
294
2759
1.09
0.60
4.5
4.3
0.00
0.00
estimate
1.08
109
936
90
791
1.15
0.60
1.5
1.4
—
—
—
0
0
10
150
0.66
0.58
1.1
1.2
—
0.60
nmol/l
—
0
9
209
2254
0.91
0.58
4.6
4.4
1.01
1.02
kg/l
1.22
40
347
522
5013
1.07
0.58
2.5
2.6
—
—
—
0
0
17
123
1.39
0.58
1.2
1.2
—
—
—
0
0
21
158
1.33
0.57
4.9
2.9
—
—
—
0
0
29
229
1.27
0.57
6.6
4.6
3.50
2.77
mmol/l
0.68
20
161
106
949
1.13
0.55
1.5
3.0
66.68
66.44
g/l
0.12
95
862
115
1035
1.12
0.54
1.6
1.5
—
—
—
0
0
16
116
1.38
0.54
1.8
2.2
—
—
—
0
0
25
195
1.29
0.54
4.4
2.9
—
—
—
0
0
12
82
1.47
0.54
1.2
1.1
—
—
—
0
0
13
91
1.43
0.53
1.3
1.0
3.07
1.10
u/ml
—
8
41
116
1048
1.12
0.52
1.6
1.6
—
—
—
0
0
9
63
1.43
0.52
2.4
1.5
—
—
—
0
0
10
146
0.68
0.52
4.8
2.0
34.10
32.44
pg
—
10
146
32
260
1.24
0.51
2.0
1.8
4894.40
14671.30
e6/l
2.41
25
186
11
75
1.47
0.50
2.1
2.4
13.55
13.31
%
0.26
11
75
13
92
1.42
0.50
1.0
1.1
—
—
—
0
0
24
189
1.28
0.49
1.2
1.5
—
—
—
0
0
17
127
1.34
0.49
1.4
1.7
40.11
61.80
%
—
9
86
10
144
0.69
0.49
1.5
1.1
—
—
—
0
0
44
372
1.19
0.49
1.6
2.0
22.66
21.60
s
0.23
38
333
312
3284
0.93
0.48
3.3
2.9
—
—
—
0
0
13
93
1.40
0.48
1.8
1.8
—
—
—
0
0
14
102
1.38
0.47
1.1
1.4
12163.25
176808.80
e6/l
—
8
71
281
2660
1.07
0.47
1.3
1.4
—
—
—
0
0
21
164
1.29
0.46
1.1
1.4
—
—
—
0
0
19
147
1.30
0.45
1.1
1.1
—
—
—
0
0
22
174
1.27
0.45
2.1
1.5
—
—
—
0
0
10
141
0.71
0.45
1.1
1.2
—
—
—
0
0
12
86
1.40
0.44
1.6
1.3
1.67
1.34
nmol/l
0.48
12
74
11
152
0.72
0.44
1.1
1.2
0.55
0.64
nmol/l
0.88
11
143
80
717
1.12
0.43
10.2
8.3
1.36
1.31
%
0.22
80
712
43
369
1.17
0.42
1.5
3.7
40.45
65.01
mg/l
0.79
36
308
18
140
1.29
0.42
1.6
1.2
—
—
—
0
0
18
140
1.29
0.42
2.4
2.7
—
—
—
0
0
104
949
1.10
0.41
7.8
7.3
9.79
9.67
mmol/l
0.06
96
902
5
33
1.52
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
46.67
—
0
6
0
15
0.00
0.41
0.0
1.2
—
205.33
—
0
9
76
682
1.12
0.41
1.3
1.3
—
—
—
0
0
31
259
1.20
0.41
1.2
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
7.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.2
—
42.88
—
0
12
16
123
1.30
0.40
1.1
1.0
1.47
1.84
u/ml
—
7
44
8
60
1.34
0.40
2.4
1.6
1.00
1.01
g/l
—
8
60
9
67
1.35
0.38
1.2
1.1
—
—
—
0
0
29
244
1.19
0.36
1.0
1.2
—
—
—
0
0
359
3456
1.05
0.36
2.3
2.4
—
—
—
0
0
138
1287
1.08
0.36
7.2
7.0
5.12
5.12
kpa
0.03
133
1235
138
1287
1.08
0.36
7.2
7.0
13.03
12.08
kpa
0.77
132
1237
36
310
1.17
0.35
1.3
1.3
—
—
—
0
0
93
853
1.10
0.35
4.5
4.1
0.06
0.13
%
0.62
31
268
10
134
0.74
0.35
1.1
1.3
—
—
nmol/l
—
0
0
69
625
1.11
0.33
1.4
1.3
—
—
—
0
0
16
127
1.26
0.33
1.0
1.1
1.42
1.54
g/l
—
10
116
14
109
1.29
0.33
1.3
1.1
—
—
—
0
0
6
46
1.31
0.33
2.5
1.4
1.53
1.60
g/l
—
6
46
88
810
1.09
0.32
4.6
4.2
0.00
0.49
%
0.67
26
222
22
183
1.21
0.32
2.3
3.4
—
—
—
0
0
7
98
0.71
0.31
4.9
1.2
—
—
—
0
0
11
142
0.77
0.30
1.1
1.1
—
—
—
0
0
7
55
1.27
0.30
1.3
1.1
118.71
465.94
u/l
—
7
50
40
451
0.88
0.29
1.5
1.4
—
—
—
0
0
89
824
1.09
0.29
4.5
3.9
0.27
0.68
%
3.41
30
270
37
418
0.88
0.28
3.9
3.6
1.29
1.38
mmol/l
0.27
37
411
65
594
1.10
0.28
8.9
9.6
—
—
—
0
0
11
140
0.78
0.28
1.2
1.1
—
—
—
0
0
11
85
1.30
0.28
1.4
1.4
—
—
—
0
0
347
3361
1.05
0.28
2.5
2.5
56.85
82.95
u/l
0.56
298
3089
8
64
1.25
0.27
9.1
6.4
—
—
—
0
0
20
168
1.19
0.27
1.1
1.4
—
—
—
0
0
15
122
1.23
0.27
1.3
1.1
1.10
1.59
u/ml
—
8
55
13
104
1.25
0.26
1.1
1.3
—
—
—
0
0
8
67
1.20
0.26
1.0
1.3
5.76
6.04
u/l
—
8
54
12
95
1.27
0.26
1.2
1.2
—
—
—
0
0
96
900
1.07
0.24
4.4
4.1
0.82
1.02
%
0.51
33
314
11
87
1.27
0.24
1.6
2.2
490.00
640.24
ml
—
6
59
6
82
0.73
0.24
1.3
1.4
—
—
—
0
0
6
82
0.73
0.24
1.3
1.4
—
—
—
0
0
6
85
0.70
0.24
1.5
1.5
—
—
—
0
0
41
370
1.11
0.23
1.5
3.7
26.27
59.89
mg/l
1.29
34
309
5
38
1.32
0.23
52.4
25.3
6.86
6.98
ug/l
—
5
33
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
5
39
1.28
0.23
3.2
2.6
35840.00
38089.87
ug/l
—
5
39
5
39
1.28
0.23
1.6
2.3
—
—
—
0
0
23
200
1.15
0.22
2.7
1.9
63.68
60.64
%
0.29
23
200
32
286
1.12
0.22
1.0
1.1
—
—
—
0
0
28
315
0.89
0.21
1.4
1.5
1.22
1.18
g/l
0.25
28
298
135
1287
1.06
0.21
7.3
7.0
0.77
1.17
mmol/l
0.65
118
1032
5
42
1.19
0.21
1.4
1.2
32.40
30.02
umol/l
—
5
42
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
27
304
0.89
0.21
3.6
4.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
46
421
1.10
0.21
3.0
2.7
—
—
—
0
0
5
43
1.16
0.21
3.4
4.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
21
183
1.15
0.20
1.1
1.3
215.08
250.12
miu/ml
—
9
79
27
240
1.13
0.20
2.5
2.4
—
—
—
0
0
72
768
0.93
0.20
3.6
4.7
—
—
—
0
0
42
458
0.91
0.19
4.2
4.4
—
—
—
0
0
6
52
1.15
0.19
1.8
1.4
—
—
—
0
0
72
677
1.07
0.18
1.1
1.2
214.15
132.76
iu/ml
0.61
21
267
59
630
0.93
0.17
1.8
3.8
18.09
71.26
u/ml
5.04
54
609
27
299
0.90
0.17
1.5
1.5
0.24
0.24
g/l
0.18
27
284
7
63
1.11
0.17
2.1
1.4
1.10
1.23
promille
—
7
52
8
69
1.16
0.16
1.0
1.0
—
—
—
0
0
130
1251
1.04
0.16
3.9
4.4
4.38
21.67
ug/l
1.88
95
1033
8
73
1.10
0.15
1.0
1.1
—
—
—
0
0
6
78
0.77
0.15
1.7
1.8
0.98
1.18
e9/l
—
6
70
30
274
1.10
0.15
1.4
4.0
—
—
—
0
0
14
161
0.87
0.15
1.7
1.2
—
—
—
0
0
9
83
1.08
0.14
1.9
2.4
—
—
—
0
0
20
179
1.12
0.14
1.1
1.4
—
—
—
0
0
20
179
1.12
0.14
1.1
1.4
—
—
—
0
0
65
617
1.06
0.14
1.2
1.4
—
—
—
0
0
38
354
1.08
0.13
1.1
1.1
—
—
—
0
0
20
180
1.11
0.13
1.1
1.4
—
—
—
0
0
12
137
0.87
0.12
1.3
1.2
—
—
—
0
0
13
115
1.13
0.10
1.2
1.6
—
—
—
0
0
14
125
1.12
0.10
1.4
1.7
—
—
—
0
0
6
54
1.11
0.09
1.0
2.1
—
—
—
0
0
43
451
0.95
0.09
2.7
3.5
2998.60
2978.27
u/ml
0.00
32
388
6
57
1.05
0.08
4.0
2.0
8.00
10.18
mmol/l
—
6
57
93
904
1.03
0.08
4.2
3.7
—
—
—
0
0
5
61
0.82
0.08
1.0
2.0
—
—
—
0
0
5
63
0.79
0.08
2.8
2.5
—
—
—
0
0
7
66
1.06
0.08
1.7
1.8
33.64
35.07
%
—
7
66
8
75
1.07
0.07
1.0
1.2
—
—
—
0
0
12
108
1.11
0.07
1.2
1.3
—
—
—
0
0
13
118
1.10
0.07
2.2
3.2
—
—
—
0
0
8
90
0.89
0.06
1.4
1.6
10.66
10.65
%
—
8
90
9
105
0.86
0.06
4.2
1.3
—
—
—
0
0
12
109
1.10
0.06
1.0
1.1
—
—
—
0
0
103
1009
1.02
0.06
3.3
3.3
2.32
1.96
mmol/l
0.62
86
847
28
267
1.05
0.05
1.1
1.5
73.19
233.22
pmol/l
2.37
28
262
12
110
1.09
0.05
1.0
1.1
—
—
—
0
0
18
169
1.07
0.05
4.6
2.0
—
—
—
0
0
19
179
1.06
0.05
1.1
1.4
—
—
—
0
0
21
199
1.06
0.04
5.0
2.7
—
—
—
0
0
42
407
1.03
0.04
1.5
1.7
—
—
—
0
0
14
131
1.07
0.03
1.1
1.3
—
—
—
0
0
15
141
1.06
0.03
1.1
1.4
—
—
—
0
0
27
262
1.03
0.02
1.0
1.1
—
—
—
0
0
11
103
1.07
0.02
1.1
1.1
—
—
—
0
0
11
103
1.07
0.02
1.2
1.4
6.85
6.58
mmol/l
0.16
11
96
10
107
0.93
0.02
1.0
1.9
—
—
—
0
0
12
113
1.06
0.02
1.4
1.4
—
—
—
0
0
12
114
1.05
0.00
1.0
1.0
—
—
—
0
0
12
126
0.95
0.00
1.6
1.8
169.92
226.88
pmol/l
0.97
12
117
11
106
1.04
0.00
1.1
1.0
0.38
0.69
u/ml
—
5
35
14
144
0.97
0.00
2.3
2.5
—
—
—
0
0
17
166
1.02
0.00
1.2
1.2
—
—
—
0
0
11
109
1.01
0.00
1.1
1.0
1.85
3.79
u/ml
—
6
45
12
119
1.01
0.00
1.2
1.3
21874.29
37686.90
e6/l
—
7
61
13
131
0.99
0.00
1.2
1.3
1247.57
1975.39
e6/l
—
7
85
51
511
1.00
0.00
1.9
2.1
14.21
12.51
nmol/l
0.62
43
456
48
483
0.99
0.00
1.6
1.5
—
—
—
0
0
16
165
0.97
0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
68
0.88
0.00
1.0
1.3
10.55
9.51
mmol/l
—
6
63
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
2.1
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
320.67
—
0
6
0
8
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
2.08
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.44
—
0
5
7
69
1.01
-0.00
1.4
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
18.19
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
1.7
1.4
43.18
30.89
u/l
—
9
74
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
-0.00
5.6
4.0
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.3
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_KERATOCONUS and mortality.

Females

Parameter HR [95% CI] p-value
H7_KERATOCONUS 0.924 [0.81, 1.05] 0.231
Birth year 0.998 [0.99, 1.01] 0.592

During the follow-up period (1.1.1998 — 31.12.2019), 527 out of 3224 females with H7_KERATOCONUS died.

Males

Parameter HR [95% CI] p-value
H7_KERATOCONUS 0.883 [0.73, 1.07] 0.197
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 1522 males with H7_KERATOCONUS died.

Mortality risk

Mortality risk for people of age

years, who have H7_KERATOCONUS.

N-year risk Females Males
1 0.09% 0.166%
5 0.582% 1.079%
10 1.379% 2.724%
15 2.655% 5.079%
20 4.734% 8.566%

Relationships between endpoints

Index endpoint: H7_KERATOCONUS – Hereditary corneal dystrophies

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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