No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1105 |
4. Check minimum number of eventsNone |
1105 |
5. Include endpointsNone |
1105 |
6. Filter based on genotype QC (FinnGen only) |
1105 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Dystrophia corneae hereditaria
Similar endpoints
↥List of similar endpoints to
Hereditary corneal dystrophies
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6239 | 4234 | 1985 |
| Only index persons | 5832 | 3982 | 1850 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.06 |
| Only index persons | 0.12 | 0.15 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 66.92 | 68.44 | 63.65 |
| Only index persons | 66.40 | 67.91 | 63.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1105 | 744 | 361 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.16 |
| Median age at first event (years) | 65.95 | 65.13 | 67.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 952
- Matched controls
- 9518
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
4503599627370496.0
323.0
942
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
356.8
226.1
220
8
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
1285.3
216.4
203
*
Z94.7
ICD-10 Finland
Corneal transplant status
2468.2
200.3
187
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
156.7
146
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
8.2
152.1
407
797
CG2S4
NOMESCO Finland
Photography of cornea
782.7
140.6
135
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
199.6
134.4
137
8
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.5
127.1
690
3081
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.6
121.1
325
604
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.8
118.5
353
758
H18.4
ICD-10 Finland
Corneal degeneration
1227.6
114.0
109
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.9
112.8
581
2319
H16.0
ICD-10 Finland
Corneal ulcer
32.8
91.4
121
42
H18.8
ICD-10 Finland
Other specified disorders of cornea
320.4
87.2
87
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
84.7
80
*
H18.6
ICD-10 Finland
Keratoconus
846.6
80.6
78
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.7
74.5
460
1911
WX140
NOMESCO Finland
Parabulbar anesthesy
8.6
63.3
145
194
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
60.0
57
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
99.6
59.7
65
7
ZXA10
NOMESCO Finland
Bilateral
3.6
57.0
328
1223
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
580.7
56.2
55
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.8
55.8
209
527
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.0
55.1
197
472
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
53.6
51
*
WX002
NOMESCO Finland
Sedation and analgesia
3.3
51.7
332
1329
H16.9
ICD-10 Finland
Keratitis, unspecified
140.1
50.3
53
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
49.4
47
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
123.4
44.2
47
*
H26.4
ICD-10 Finland
After-cataract
4.0
43.4
193
564
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.1
41.5
178
501
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.6
40.4
448
2442
E85.80
ICD-10 Finland
Meretoja sick
+∞
39.9
38
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
36.7
35
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
35.6
34
*
ZXA05
NOMESCO Finland
Left side
2.5
32.4
345
1780
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
74.5
32.1
36
5
ZXA00
NOMESCO Finland
Right side
2.3
29.6
350
1889
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
29.4
152
493
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
29.3
28
*
S01ED01
ATC
timolol; ophthalmic
6.2
29.2
81
140
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
11.9
28.7
53
47
S01AD03
ATC
aciclovir; ophthalmic
6.8
27.9
72
113
CGE10
NOMESCO Finland
Keratectomy
+∞
27.2
26
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
25.1
24
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
24.1
23
*
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
22.0
21
*
S01ED51
ATC
timolol, combinations; ophthalmic
3.3
21.7
115
377
H17.8
ICD-10 Finland
Other corneal scars and opacities
224.9
21.7
22
*
S01EA03
ATC
apraclonidine; ophthalmic
13.7
21.6
37
28
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.5
20.7
100
305
H52.2
ICD-10 Finland
Astigmatism
9.9
20.5
41
43
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
19.9
19
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
19.9
19
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
18.8
18
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
17.0
139
597
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.9
16.6
30
26
H25.8
ICD-10 Finland
Other senile cataract
2.4
16.6
150
682
CGF10
NOMESCO Finland
Suture of laceration of cornea
172.9
16.5
17
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
15.7
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
15.2
172
868
3715A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Hereditary corneal dystrophies
+∞
14.6
14
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
5.0
14.5
46
95
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
6.8
14.1
35
53
37102
ICD-8 Finland
Corneal opacity, Dystrophia corneae hereditaria
+∞
13.6
13
*
3604
FHL
Penetration of the cornea
+∞
13.6
13
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.6
13.0
97
395
S01EE01
ATC
latanoprost; ophthalmic
2.8
12.9
86
327
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
12.5
12.6
22
18
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
12.5
12
*
114
Kela drug reimbursment
Glaucoma
2.4
12.2
110
497
H25.0
ICD-10 Finland
Senile incipient cataract
2.8
11.8
78
297
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.2
11.8
63
209
CD2S4
NOMESCO Finland
Photography of eye
16.7
11.7
18
11
S01XA18
ATC
ciclosporin; ophthalmic
16.7
11.7
18
11
XCH00
NOMESCO Finland
Eye pressure measurement
3.4
11.6
55
167
WX142
NOMESCO Finland
Sub-tenon anesthesy
11.3
11.6
21
19
H19.8
ICD-10 Finland
Other disorders of sclera and cornea in diseases classified elsewhere
+∞
11.5
11
*
XCK00
NOMESCO Finland
Perimetry
2.6
11.4
85
346
S01AX11
ATC
[U] ofloxacin; ophthalmic
3.6
10.7
48
140
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
111.2
10.4
11
*
H16.8
ICD-10 Finland
Other keratitis
111.2
10.4
11
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
111.2
10.4
11
*
H18.7
ICD-10 Finland
Other corneal deformities
+∞
10.4
10
*
S01EE05
ATC
tafluprost; ophthalmic
3.3
10.3
52
166
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.9
10.1
60
215
H26.02
ICD-10 Finland
Presenil cataract
3.8
9.8
40
108
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
3.7
9.7
41
114
S01FA01
ATC
atropine; ophthalmic
11.5
9.6
17
15
WX110
NOMESCO Finland
Local anesthesy
1.5
9.4
607
5063
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
9.4
9
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
9.4
9
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
9.4
9
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
9.4
9
*
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
9.4
9
*
S01EC01
ATC
acetazolamide; systemic
4.6
9.3
31
69
H26.2
ICD-10 Finland
Complicated cataract
6.8
9.2
22
33
CKD60
NOMESCO Finland
Anterior vitrectomy
7.8
9.2
20
26
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.6
9.0
22
34
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
11.7
8.6
15
13
S01BC03
ATC
diclofenac; ophthalmic
4.2
8.5
31
76
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.3
8.5
42
133
QAJ20
NOMESCO Finland
Subperiosteal facelift
90.8
8.4
9
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
8.3
8
*
H57.1
ICD-10 Finland
Ocular pain
3.9
8.1
32
85
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
5.3
8.0
23
44
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.3
7.8
67
298
S01ED02
ATC
betaxolol; ophthalmic
5.5
7.6
21
39
S01EE04
ATC
travoprost; ophthalmic
3.8
7.5
30
81
QAJ15
NOMESCO Finland
Browlift using video-endoscope
80.7
7.4
8
*
H52.1
ICD-10 Finland
Myopia
4.0
7.4
28
72
H10.4
ICD-10 Finland
Chronic conjunctivitis
8.4
7.3
15
18
F29
ICPC
Eye symptom/complaint other
2.1
7.3
76
370
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
7.3
7
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
7.3
7
*
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
7.3
7
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
7.3
7
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
7.3
7
*
S01EC04
ATC
brinzolamide; ophthalmic
2.7
7.1
45
169
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
7.0
168
1090
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.5
6.9
53
223
S01KA02
ATC
hypromellose; ophthalmic
3.6
6.9
29
82
QAJ30
NOMESCO Finland
Other facelift
13.9
6.9
11
8
H02.2
ICD-10 Finland
Lagophthalmos
9.4
6.8
13
14
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.7
6.7
43
161
H02.1
ICD-10 Finland
Ectropion of eyelid
5.5
6.6
18
33
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
2.9
6.5
37
129
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.0
6.3
16
27
H02.4
ICD-10 Finland
Ptosis of eyelid
3.0
6.3
34
117
S01AA12
ATC
tobramycin; ophthalmic
18.1
6.3
9
5
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
6.3
6
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
6.3
6
*
H21.0
ICD-10 Finland
Hyphaema
+∞
6.3
6
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
6.3
6
*
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
6.3
6
*
EAB20
NOMESCO Finland
Plastic repair of lip
+∞
6.3
6
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
26.9
6.2
8
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
26.9
6.2
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.2
345
2703
H27.0
ICD-10 Finland
Aphakia
12.6
6.1
10
8
S01BC05
ATC
ketorolac; ophthalmic
2.5
6.0
46
192
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
64
5.61
18.45
1.3
1.3
—
—
—
0
0
1055
9662
3.03
14.34
19.5
17.8
4.0
4.0
mmol/l
0.85
1021
9385
1053
9639
2.96
14.23
19.4
17.7
139.7
139.7
mmol/l
0.52
1022
9378
965
8565
2.00
13.28
5.5
5.0
1.9
2.1
mu/l
0.59
858
7720
580
4530
1.59
12.70
5.9
5.8
1.2
1.2
mmol/l
0.76
515
4074
1011
9185
2.18
12.13
16.1
15.0
24.0
24.6
mg/l
0.20
811
7322
521
4025
1.56
11.57
2.4
2.3
79.7
79.1
nmol/l
0.18
443
3548
970
8757
1.88
10.76
16.0
14.2
76.9
76.8
ml/min/173m2
0.04
796
7195
612
4957
1.53
10.57
6.8
6.6
1.2
1.2
mmol/l
0.55
495
4175
810
6993
1.59
10.36
4.4
4.2
12.9
13.5
mm/h
0.50
724
6408
19
34
5.67
10.24
1.2
1.3
—
—
—
0
0
1050
9798
2.44
9.95
11.8
10.9
24.1
24.8
u/l
0.68
1002
9413
1013
9340
2.02
9.62
5.6
5.2
2.7
2.7
mmol/l
0.62
909
8475
1070
10112
2.84
9.13
24.9
22.4
248.1
250.7
e9/l
0.65
1034
9830
957
8699
1.75
9.09
6.5
6.1
40.2
40.1
mmol/mol
0.06
859
7965
1070
10114
2.83
9.09
24.9
22.4
4.4
4.4
e12/l
0.60
1029
9801
1070
10115
2.83
9.07
25.0
22.5
132.7
133.2
g/l
0.53
1052
9945
994
9140
1.87
9.03
5.0
4.6
4.6
4.7
mmol/l
0.36
896
8338
991
9109
1.85
8.94
5.3
4.8
6.0
6.0
mmol/l
0.44
877
8178
516
4139
1.46
8.68
2.1
2.1
100.4
95.8
pmol/l
1.05
248
2084
902
8138
1.59
8.07
18.1
16.4
38.9
38.9
%
0.02
606
5417
982
9067
1.75
7.83
5.0
4.6
1.5
1.5
mmol/l
0.06
876
8210
816
7224
1.50
7.77
4.6
4.2
14.9
15.0
pmol/l
0.19
718
6499
205
1383
1.59
7.74
2.5
2.4
2.3
2.3
g/l
0.12
188
1288
951
8752
1.62
7.12
4.4
4.1
1.3
1.3
mmol/l
0.33
840
7858
230
1634
1.51
6.84
2.5
2.8
0.8
1.3
e6/l
3.31
128
956
191
1305
1.56
6.78
2.6
2.4
23.6
22.3
%
0.59
164
1118
216
1521
1.52
6.68
2.7
3.0
4.5
2.9
e6/l
0.94
117
847
821
7365
1.45
6.55
7.7
7.6
78.0
79.5
u/l
0.52
758
6891
724
6371
1.40
6.30
5.0
4.9
458.3
2934.9
e6/l
—
7
97
429
3471
1.39
6.24
3.5
3.5
2.4
2.4
mmol/l
0.46
342
2983
209
1506
1.48
5.73
2.6
2.4
13.7
12.7
umol/l
0.95
191
1394
337
2670
1.38
5.41
3.1
3.2
0.5
0.5
e6/l
0.02
248
2044
149
1016
1.54
5.30
3.9
3.4
—
—
—
0
0
310
2447
1.37
5.04
2.4
2.1
2.9
3.1
mg/l
0.79
263
2064
144
1003
1.50
4.64
2.5
2.0
161.1
127.1
ug/g
0.45
107
788
319
2578
1.33
4.35
1.7
1.7
1.3
1.3
mmol/l
0.13
267
2140
500
4314
1.29
4.18
4.9
4.6
35.4
35.2
g/l
0.37
443
3991
370
3074
1.31
4.11
3.2
3.0
1731.8
1314.5
ng/l
0.67
304
2619
814
7498
1.33
4.06
20.6
18.5
13.7
13.8
%
0.32
796
7330
577
5087
1.28
4.01
5.7
6.3
10.8
11.3
umol/l
0.75
528
4818
24
102
2.38
3.76
1.1
1.2
50.8
50.8
u/l
0.00
17
73
627
5613
1.27
3.73
4.8
4.7
6.7
6.8
mmol/l
0.57
589
5268
237
1876
1.34
3.66
3.9
4.0
150.9
331.3
ng/l
2.09
198
1511
521
4583
1.26
3.52
4.0
3.9
0.0
0.0
estimate
0.00
100
867
448
3875
1.26
3.48
3.3
2.7
112.5
133.3
ug/l
1.79
406
3526
170
1290
1.38
3.45
23.1
25.7
1.5
1.3
inr
0.44
20
166
61
374
1.67
3.43
2.1
2.1
37.1
39.3
u/l
0.46
54
324
167
1265
1.38
3.42
5.3
4.8
33.2
33.0
%
0.10
113
811
251
2028
1.31
3.34
1.7
1.6
1.5
1.2
mg/l
0.47
183
1568
527
4664
1.25
3.30
4.0
3.9
0.0
0.0
estimate
0.80
97
850
605
5449
1.24
3.20
8.8
9.0
4.0
4.1
e9/l
0.66
517
4750
243
1967
1.30
3.18
2.8
3.1
2.5
2.5
mmol/l
1.31
204
1731
435
3791
1.24
3.07
4.1
3.8
190.2
60.4
ng/l
0.48
319
2768
519
4618
1.23
3.00
5.5
5.3
0.0
0.0
estimate
0.50
98
871
290
2423
1.27
2.93
2.5
2.7
2522.4
6944.9
umol/l
1.67
236
2064
32
170
1.91
2.93
1.4
1.2
—
—
—
0
0
290
2424
1.27
2.92
1.6
1.5
23.2
21.1
nmol/l
1.26
229
2028
112
816
1.41
2.90
3.6
3.4
91.1
84.8
ng/l
0.28
93
702
249
2050
1.28
2.84
2.6
2.6
4.3
6.3
e6/l
2.68
212
1808
557
5013
1.22
2.82
2.8
2.7
—
—
—
0
0
626
5704
1.22
2.80
3.4
3.1
42.4
51.1
u/l
2.65
571
5259
117
871
1.38
2.68
1.8
2.4
33.9
35.2
u/l
0.13
95
752
112
828
1.39
2.68
5.0
3.7
1.2
1.2
mmol/l
0.04
92
715
237
1959
1.27
2.60
1.8
1.7
1062.4
1187.7
nmol/l
1.24
153
1442
353
3061
1.23
2.51
3.6
3.2
6.8
7.0
mmol/l
0.45
288
2524
231
1918
1.26
2.44
1.3
1.3
2.1
1.7
u/ml
0.18
62
508
32
183
1.77
2.37
4.6
2.4
16.6
16.1
%
0.27
18
103
344
2997
1.21
2.31
2.1
2.1
151.7
217.2
u/l
1.49
307
2815
58
390
1.51
2.30
4.7
4.1
25.7
25.1
mmol/l
0.88
53
361
189
1544
1.27
2.28
1.3
1.2
10.4
14.8
u/ml
0.27
53
553
45
287
1.59
2.25
1.2
1.1
—
—
—
0
0
356
3134
1.20
2.11
4.4
4.0
9.1
8.1
mg/mmol
0.16
209
1893
193
1597
1.25
2.10
1.4
1.3
30.6
37.2
iu/ml
0.28
63
521
76
552
1.40
2.06
3.3
3.1
4.5
4.5
pmol/l
0.10
65
478
40
255
1.59
2.03
1.3
1.2
28.2
4.0
u/ml
—
5
47
190
1579
1.25
1.99
3.0
3.3
0.8
0.8
mmol/l
0.30
178
1468
166
1360
1.26
1.97
3.0
3.1
0.8
0.8
ug/l
0.15
126
920
111
865
1.31
1.94
7.5
6.2
1.2
1.4
mmol/l
1.72
106
829
34
212
1.62
1.90
1.2
1.2
—
—
—
0
0
140
1129
1.27
1.89
2.0
2.5
1.7
1.8
%
0.43
120
1009
79
587
1.37
1.89
4.7
3.6
2.4
2.0
mmol/l
0.40
65
455
41
268
1.55
1.89
1.3
1.2
—
13.9
—
0
15
154
1258
1.26
1.88
7.4
7.5
—
—
—
0
0
43
285
1.53
1.87
1.2
1.1
—
—
—
0
0
8
29
2.77
1.79
1.9
1.1
10.5
9.2
ug/l
—
8
29
33
208
1.60
1.78
1.1
1.4
—
—
—
0
0
20
109
1.85
1.78
2.8
1.8
89.8
89.0
%
0.27
20
109
328
2913
1.18
1.72
2.9
3.2
30.8
32.7
u/l
0.24
303
2763
28
172
1.64
1.68
2.7
2.7
4.0
4.4
e9/l
0.44
28
172
20
112
1.80
1.65
1.1
1.0
—
—
—
0
0
11
49
2.26
1.64
1.1
1.4
—
—
—
0
0
11
49
2.26
1.64
1.1
1.4
—
—
—
0
0
62
455
1.38
1.63
1.4
1.8
1.5
1.6
g/l
0.36
56
394
5
14
3.58
1.61
1.8
1.5
—
—
—
0
0
43
296
1.47
1.60
1.5
1.5
292.6
293.5
ug/g
0.01
27
178
53
380
1.41
1.60
1.4
2.7
10.9
10.3
g/l
0.47
42
323
152
1270
1.23
1.54
6.4
5.0
1.0
1.0
mmol/l
0.37
138
1157
7
27
2.60
1.51
1.6
1.9
—
—
—
0
0
130
1071
1.24
1.50
3.5
4.1
231.0
252.8
u/l
0.94
124
1009
128
1053
1.24
1.50
2.0
2.7
9.9
8.0
umol/l
0.23
110
909
28
179
1.58
1.47
3.2
3.0
56.3
59.3
%
0.55
28
179
9
38
2.38
1.45
8.4
4.9
—
—
—
0
0
267
2363
1.17
1.45
4.9
5.3
2.5
3.2
ug/l
0.48
233
2096
5
16
3.13
1.44
1.0
1.1
—
—
—
0
0
5
16
3.13
1.44
1.2
1.0
—
—
—
0
0
46
329
1.42
1.43
1.5
2.6
38.7
37.3
g/l
1.00
39
283
55
408
1.37
1.39
1.4
2.7
3.7
3.8
g/l
0.26
39
296
79
619
1.30
1.38
4.8
3.7
5.3
5.2
kpa
0.77
73
578
49
357
1.39
1.38
1.5
2.9
0.6
1.2
g/l
0.79
41
315
55
409
1.36
1.37
1.4
2.7
—
—
—
0
0
55
409
1.36
1.37
1.4
2.7
7.6
7.5
g/l
0.15
39
312
9
41
2.20
1.37
1.0
1.0
—
—
—
0
0
9
41
2.20
1.37
2.4
3.1
586.0
1015.0
u/ml
—
9
41
37
257
1.45
1.35
2.1
1.7
—
—
—
0
0
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
52
385
1.37
1.34
1.4
2.7
3.3
3.2
g/l
0.17
39
302
31
209
1.50
1.31
1.3
1.5
—
—
—
0
0
30
201
1.51
1.31
1.8
1.7
—
—
—
0
0
22
138
1.61
1.27
1.5
1.3
—
—
—
0
0
80
638
1.27
1.24
1.5
1.7
—
—
—
0
0
35
245
1.44
1.24
3.9
3.1
1.4
1.6
mg/l
0.59
30
222
115
957
1.23
1.24
2.3
2.0
0.2
0.2
g/l
0.32
108
907
25
163
1.55
1.24
1.2
1.2
44.3
32.9
u/l
0.15
18
140
55
417
1.34
1.23
1.5
1.3
—
—
—
0
0
106
875
1.23
1.23
2.0
2.5
8.9
7.6
ug/l
0.16
87
769
103
849
1.24
1.21
1.7
1.7
1.4
1.5
%
1.06
84
722
8
37
2.17
1.21
1.0
1.0
—
—
—
0
0
42
306
1.39
1.21
1.5
1.6
—
101.7
—
0
12
95
777
1.24
1.20
3.0
2.7
63.0
63.3
ml/min/173m2
0.03
36
332
36
256
1.42
1.19
1.7
1.5
109.1
0.3
iu/ml
—
10
53
133
1130
1.20
1.17
1.5
1.8
—
—
—
0
0
0
33
0.00
1.16
0.0
2.9
—
—
—
0
0
0
33
0.00
1.16
0.0
2.9
—
—
—
0
0
102
845
1.23
1.16
2.8
2.1
393.4
377.6
nmol/l
0.30
92
770
40
294
1.37
1.11
1.4
1.8
—
—
—
0
0
100
834
1.22
1.08
8.0
6.8
9.8
9.7
mmol/l
0.03
92
793
10
52
1.93
1.06
1.5
1.5
—
—
—
0
0
10
52
1.93
1.06
1.5
1.5
—
—
—
0
0
17
106
1.61
1.03
3.5
2.5
—
—
—
0
0
78
637
1.24
1.03
10.3
8.0
1.4
1.3
%
0.16
78
632
259
2347
1.14
1.01
2.3
2.3
—
—
—
0
0
181
1611
1.15
0.93
1.6
1.9
—
—
—
0
0
19
126
1.52
0.91
1.1
1.2
223.6
250.3
u/ml
0.14
12
71
16
243
0.65
0.91
1.3
1.7
—
—
—
0
0
146
1282
1.16
0.91
1.5
1.4
—
—
—
0
0
132
1151
1.17
0.90
7.5
6.9
13.1
12.1
kpa
0.86
127
1104
20
135
1.49
0.89
1.1
1.2
—
—
—
0
0
12
71
1.70
0.89
1.5
1.6
—
—
—
0
0
19
127
1.50
0.89
1.3
1.6
—
—
—
0
0
19
127
1.50
0.89
1.3
1.6
—
—
—
0
0
29
213
1.37
0.85
3.7
2.1
132.7
128.6
g/l
0.38
20
154
20
137
1.47
0.84
1.2
1.1
—
—
—
0
0
477
4514
1.10
0.84
3.8
4.0
—
—
—
0
0
19
129
1.48
0.83
1.3
1.6
—
—
—
0
0
15
97
1.55
0.81
1.4
1.7
—
—
—
0
0
19
131
1.46
0.78
1.3
1.5
—
—
—
0
0
19
131
1.46
0.78
1.3
1.5
—
—
—
0
0
12
74
1.63
0.78
2.0
1.2
2.4
0.9
u/ml
—
5
35
14
90
1.56
0.78
2.5
1.8
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
—
—
0
0
12
75
1.61
0.75
1.6
1.2
1.7
1.3
nmol/l
0.51
12
64
100
868
1.17
0.74
2.4
2.9
214.6
200.3
ng/l
0.16
93
795
5
24
2.09
0.74
1.4
1.3
—
—
—
0
0
32
245
1.32
0.74
2.6
2.4
110.7
100.0
ug/min
0.05
14
149
6
107
0.56
0.72
1.0
1.7
—
—
—
0
0
98
853
1.16
0.71
1.6
3.1
66.6
66.4
g/l
0.09
88
773
9
146
0.61
0.69
1.7
1.5
—
—
—
0
0
68
576
1.19
0.68
1.5
1.5
—
—
—
0
0
10
61
1.65
0.68
1.5
1.4
—
—
—
0
0
268
2492
1.10
0.67
4.5
4.3
0.0
0.0
estimate
0.80
96
841
81
698
1.17
0.67
1.9
1.6
—
—
—
0
0
35
276
1.28
0.67
1.6
1.4
—
—
—
0
0
129
1152
1.14
0.67
7.6
6.9
0.7
1.1
mmol/l
0.81
112
910
37
295
1.26
0.65
2.1
1.8
1.6
4.9
mg/l
1.12
31
224
127
1135
1.13
0.65
1.5
1.8
—
—
—
0
0
41
332
1.24
0.64
1.4
3.9
40.4
67.4
mg/l
0.79
36
279
33
261
1.27
0.63
1.8
1.5
—
—
—
0
0
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
16
113
1.42
0.61
1.4
1.7
38.9
61.8
%
—
8
78
9
138
0.65
0.61
1.1
1.2
0.5
0.6
nmol/l
—
9
129
0
21
0.00
0.60
0.0
2.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
18
131
1.38
0.59
1.3
1.5
—
—
—
0
0
8
53
1.51
0.58
2.4
1.6
1.0
1.0
g/l
—
8
53
15
106
1.42
0.58
1.1
1.1
—
—
—
0
0
48
403
1.20
0.56
1.0
1.0
—
—
—
0
0
60
515
1.17
0.55
1.5
1.3
306.9
166.8
u/ml
0.56
53
466
6
39
1.54
0.53
1.0
1.3
—
—
—
0
0
204
1897
1.09
0.53
3.9
4.6
24.1
21.1
%
1.73
100
957
231
2162
1.09
0.52
1.7
1.7
55882811.5
22892001.0
pmol/l
0.25
170
1743
6
99
0.60
0.52
1.0
1.7
—
—
—
0
0
9
136
0.66
0.51
1.1
1.2
—
0.6
nmol/l
—
0
9
29
235
1.24
0.48
2.0
1.8
4893.5
15317.6
e6/l
2.27
22
167
10
68
1.47
0.47
2.2
2.5
13.5
13.3
%
—
10
68
28
227
1.24
0.47
1.5
1.7
3.2
4.8
iu/l
—
9
71
67
590
1.14
0.46
1.1
1.2
224.5
130.4
iu/ml
0.70
20
237
122
1117
1.10
0.45
3.8
4.4
3.9
23.4
ug/l
1.92
90
923
25
201
1.25
0.45
1.1
1.3
—
—
—
0
0
25
201
1.25
0.45
1.1
1.3
—
—
—
0
0
191
2037
0.92
0.43
4.7
4.4
1.0
1.0
kg/l
0.85
33
306
32
267
1.20
0.42
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
14
105
1.34
0.41
1.1
1.0
1.5
1.5
u/ml
—
7
36
39
333
1.18
0.41
1.5
3.9
26.3
62.9
mg/l
1.27
34
280
8
59
1.36
0.41
1.0
1.3
5.8
6.1
u/l
—
8
48
11
79
1.40
0.40
1.6
2.3
490.0
631.6
ml
—
6
53
0
17
0.00
0.40
0.0
1.9
—
1.2
—
0
17
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
314
3006
1.06
0.39
2.5
2.5
55.6
58.3
u/l
0.76
271
2760
14
106
1.32
0.39
1.6
1.3
8.1
7.3
mmol/l
—
8
72
5
37
1.35
0.37
1.4
1.3
32.4
30.4
umol/l
—
5
37
16
125
1.28
0.37
1.4
1.6
—
—
—
0
0
27
321
0.84
0.36
4.8
3.8
3.8
3.9
mmol/l
0.32
27
300
6
43
1.40
0.35
1.3
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
—
—
—
0
0
10
73
1.37
0.34
1.0
1.2
—
—
—
0
0
6
46
1.31
0.33
1.3
1.3
—
—
—
0
0
6
46
1.31
0.33
1.3
1.3
—
—
—
0
0
6
88
0.68
0.33
1.5
1.5
—
—
—
0
0
6
47
1.28
0.32
1.0
1.3
—
—
—
0
0
29
248
1.17
0.32
1.3
1.5
—
—
—
0
0
12
92
1.31
0.32
1.2
1.4
2567.7
198736.8
e6/l
—
6
64
28
239
1.18
0.31
1.4
1.4
—
—
—
0
0
14
111
1.26
0.30
1.0
1.1
1.4
1.5
g/l
—
9
102
24
203
1.19
0.30
1.3
1.3
—
—
—
0
0
7
55
1.27
0.30
3.0
2.3
—
—
—
0
0
7
56
1.25
0.29
1.3
1.3
—
—
—
0
0
7
56
1.25
0.29
1.3
1.3
—
—
—
0
0
151
1428
1.07
0.29
1.4
1.3
—
—
—
0
0
13
162
0.80
0.28
1.4
1.5
—
—
—
0
0
364
3534
1.04
0.27
4.6
4.2
—
—
—
0
0
8
65
1.23
0.27
1.0
1.2
—
—
—
0
0
8
65
1.23
0.27
1.0
1.2
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
9
76
1.19
0.24
1.3
1.1
—
—
—
0
0
51
558
0.91
0.24
1.8
4.0
18.9
67.0
u/ml
4.07
46
538
6
81
0.74
0.24
1.7
1.4
—
—
—
0
0
6
84
0.71
0.24
1.3
1.4
—
—
—
0
0
6
84
0.71
0.24
1.3
1.4
—
—
—
0
0
6
84
0.71
0.24
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
11.1
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
19
164
1.16
0.20
1.2
1.2
231.8
248.7
miu/ml
—
8
70
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
48
1.25
0.20
1.3
1.1
135.5
525.2
u/l
—
6
43
6
51
1.18
0.19
1.0
1.9
—
—
—
0
0
96
911
1.06
0.19
3.4
3.2
2.3
2.0
mmol/l
0.43
80
732
7
61
1.15
0.17
1.4
1.8
—
—
—
0
0
12
142
0.84
0.17
1.4
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
320
1.10
0.17
3.9
2.6
0.3
0.4
u/ml
0.58
22
187
34
369
0.92
0.15
1.7
1.8
—
—
—
0
0
9
83
1.08
0.14
1.7
1.4
43.2
30.5
u/l
—
9
68
27
295
0.91
0.14
1.1
1.2
—
—
—
0
0
11
128
0.86
0.13
1.5
1.5
—
—
—
0
0
15
132
1.14
0.13
1.1
1.1
—
—
—
0
0
38
405
0.94
0.12
1.8
2.0
—
—
—
0
0
12
105
1.14
0.11
1.2
1.3
21874.3
41739.0
e6/l
—
7
51
35
373
0.94
0.11
4.0
3.6
1.3
1.4
mmol/l
0.46
35
367
10
86
1.16
0.11
1.2
1.1
—
50.5
—
0
6
25
231
1.08
0.10
1.1
1.5
76.6
299.6
pmol/l
2.34
25
226
5
46
1.09
0.09
1.4
1.5
—
—
—
0
0
5
48
1.04
0.09
1.2
4.2
—
94.3
—
0
8
6
56
1.07
0.08
1.0
1.2
—
—
—
0
0
12
107
1.12
0.08
1.3
1.1
0.2
1.5
u/ml
—
5
36
35
332
1.06
0.08
2.3
3.0
—
—
—
0
0
7
68
1.03
0.08
1.1
1.2
5.7
13.8
u/l
—
7
63
6
71
0.84
0.07
1.0
1.0
—
—
—
0
0
19
177
1.07
0.06
1.2
1.3
—
92.0
—
0
5
45
467
0.96
0.06
1.6
2.2
14.3
12.5
nmol/l
0.55
38
413
19
203
0.93
0.06
1.2
1.1
—
—
—
0
0
43
446
0.96
0.06
1.7
1.7
—
—
—
0
0
49
506
0.97
0.05
2.0
1.8
—
—
—
0
0
27
258
1.05
0.04
1.4
1.7
—
—
—
0
0
27
282
0.96
0.04
1.4
1.5
1.2
1.2
g/l
0.23
27
268
17
160
1.06
0.04
1.4
1.7
—
—
—
0
0
40
412
0.97
0.04
2.5
3.6
3197.6
3178.8
u/ml
0.00
30
359
26
268
0.97
0.02
1.5
1.5
0.2
0.2
g/l
0.24
26
256
59
598
0.99
0.01
1.9
1.7
—
—
—
0
0
22
227
0.97
0.01
1.3
1.6
—
—
—
0
0
25
244
1.03
0.00
4.1
3.0
24.6
25.2
mmol/l
0.41
25
217
13
132
0.98
0.00
2.0
2.7
—
588.2
—
0
10
23
228
1.01
0.00
1.7
1.9
—
—
—
0
0
18
179
1.01
0.00
1.3
1.8
—
—
—
0
0
22
219
1.00
0.00
1.3
1.6
—
—
—
0
0
11
113
0.97
0.00
1.5
1.8
169.2
231.6
pmol/l
0.96
11
105
12
123
0.98
0.00
1.4
1.5
—
—
—
0
0
12
115
1.04
0.00
1.0
1.1
—
—
—
0
0
20
205
0.98
0.00
6.7
3.0
34.1
32.2
umol/l
0.13
15
173
7
75
0.93
0.00
1.0
1.1
—
—
—
0
0
5
54
0.93
0.00
1.2
1.3
—
—
—
0
0
5
54
0.93
0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
434.0
—
0
7
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
22
220
1.00
0.00
5.0
2.8
8.2
8.1
kpa
0.22
22
204
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
13
130
1.00
0.00
2.1
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
7.8
—
0
5
9
98
0.92
0.00
4.2
4.1
—
—
—
0
0
8
86
0.93
0.00
3.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
2.8
—
0
6
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_KERATOCONUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATOCONUS | 0.924 [0.81, 1.05] | 0.231 |
| Birth year | 0.998 [0.99, 1.01] | 0.592 |
During the follow-up period (1.1.1998 — 31.12.2019), 527 out of 3224 females with H7_KERATOCONUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATOCONUS | 0.883 [0.73, 1.07] | 0.197 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 1522 males with H7_KERATOCONUS died.
Mortality risk
Mortality risk for people of age
years, who have H7_KERATOCONUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.166% |
| 5 | 0.582% | 1.079% |
| 10 | 1.379% | 2.724% |
| 15 | 2.655% | 5.079% |
| 20 | 4.734% | 8.566% |
Relationships between endpoints
↥Index endpoint: H7_KERATOCONUS – Hereditary corneal dystrophies
GWS hits: 20
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data