No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
930 |
4. Check minimum number of eventsNone |
930 |
5. Include endpointsNone |
930 |
6. Filter based on genotype QC (FinnGen only) |
930 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Keratoconus
Similar endpoints
↥List of similar endpoints to
Keratoconus
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7756 | 2530 | 5162 |
| Only index persons | 7472 | 2441 | 5031 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.07 | 0.14 |
| Only index persons | 0.16 | 0.09 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 36.99 | 41.37 | 34.91 |
| Only index persons | 36.87 | 41.09 | 34.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 930 | 403 | 527 |
| Unadjusted period prevalence (%) | 0.19 | 0.14 | 0.23 |
| Median age at first event (years) | 40.96 | 43.61 | 38.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 838
- Matched controls
- 8379
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.6
ICD-10 Finland
Keratoconus
4503599627370496.0
323.0
815
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
208.2
191
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
261.2
185.6
184
9
CGG11
NOMESCO Finland
Corneal cross-linking
1677.5
148.5
140
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
145.1
135
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
1437.2
129.7
123
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.4
128.0
262
320
WX100
NOMESCO Finland
Conjunctival surface anesthesia
11.7
116.7
233
266
TCG10
NOMESCO Finland
Removal of sutures from cornea
326.7
114.1
113
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.5
113.0
498
1768
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
856.6
80.8
78
*
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
75.1
71
*
H52.2
ICD-10 Finland
Astigmatism
29.9
71.0
96
36
WX140
NOMESCO Finland
Parabulbar anesthesy
14.6
63.0
109
85
CGD40
NOMESCO Finland
Implantation of intracorneal ring segments
+∞
62.3
59
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.1
58.1
153
255
ZXA10
NOMESCO Finland
Bilateral
4.3
54.9
240
716
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.0
54.5
197
484
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.4
52.4
342
1418
3604
FHL
Penetration of the cornea
+∞
50.5
48
*
H16.0
ICD-10 Finland
Corneal ulcer
15.4
45.4
76
54
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
44.1
42
*
WX002
NOMESCO Finland
Sedation and analgesia
3.6
44.0
240
846
37103
ICD-8 Finland
Corneal opacity, Keratoconus
+∞
42.0
40
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.8
41.7
151
364
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
40.3
205
677
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.5
39.7
221
782
H16.9
ICD-10 Finland
Keratitis, unspecified
107.6
38.1
41
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
23.5
37.0
53
24
ZXA00
NOMESCO Finland
Right side
3.0
36.9
271
1160
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
36.7
35
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
36.7
35
*
ZXA05
NOMESCO Finland
Left side
3.0
35.8
257
1079
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.4
34.5
95
164
CG2S4
NOMESCO Finland
Photography of cornea
350.6
34.2
34
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
176.9
32.9
34
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
32.5
31
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
31.4
30
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
8.3
29.2
66
85
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
27.2
26
*
H18.4
ICD-10 Finland
Corneal degeneration
279.5
26.9
27
*
H18.7
ICD-10 Finland
Other corneal deformities
279.5
26.9
27
*
S01ED01
ATC
timolol; ophthalmic
10.4
26.8
53
54
H25.1
ICD-10 Finland
Senile nuclear cataract
3.0
25.2
162
616
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.3
24.8
97
248
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
133.9
24.7
26
*
S01GX01
ATC
cromoglicic acid; ophthalmic
2.5
22.0
207
981
S01FA01
ATC
atropine; ophthalmic
51.4
21.2
25
5
S01AD03
ATC
aciclovir; ophthalmic
7.7
21.0
49
67
H18.8
ICD-10 Finland
Other specified disorders of cornea
215.0
20.7
21
*
H26.4
ICD-10 Finland
After-cataract
4.3
19.9
77
194
H18.2
ICD-10 Finland
Other corneal oedema
+∞
19.9
19
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
204.5
19.6
20
*
H26.2
ICD-10 Finland
Complicated cataract
12.2
18.9
34
29
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
18.8
18
*
H16.8
ICD-10 Finland
Other keratitis
+∞
18.8
18
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
194.1
18.6
19
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
53.7
18.0
21
*
3606
FHL
Keratophakic corneal surgery
+∞
17.8
17
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
22.4
16.9
24
11
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.2
16.8
66
169
S01AX11
ATC
[U] ofloxacin; ophthalmic
5.5
16.1
48
92
L20.0
ICD-10 Finland
Besnier prurigo
3.4
16.1
82
262
S01AA12
ATC
tobramycin; ophthalmic
48.5
16.1
19
*
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
15.7
15
*
S01EA03
ATC
apraclonidine; ophthalmic
19.7
15.6
23
12
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
8.9
15.3
32
37
H16.2
ICD-10 Finland
Keratoconjunctivitis
57.7
14.8
17
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
8.9
14.8
31
36
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
14.6
14
*
H26.02
ICD-10 Finland
Presenil cataract
5.8
14.5
41
74
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
8.4
13.9
30
37
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
13.6
13
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
142.2
13.5
14
*
D07AA02
ATC
hydrocortisone; topical
2.2
12.9
137
672
9881
FHL
Bandage replacement, suture or spike removal, or the like in an operating room or anesthesia
50.8
12.9
15
*
XCK00
NOMESCO Finland
Perimetry
3.5
12.8
61
186
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
70.9
12.6
14
*
D11AH01
ATC
tacrolimus; topical
10.7
11.8
22
21
S01EC01
ATC
acetazolamide; systemic
7.5
11.8
27
37
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
11.7
76
287
CFD10
NOMESCO Finland
Repair of conjunctiva
65.9
11.6
13
*
S01ED51
ATC
timolol, combinations; ophthalmic
3.5
11.5
54
163
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
11.5
11
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.4
11.3
26
36
E000001
ATC
NA
1.9
11.1
170
970
H02AB06
ATC
prednisolone; systemic
1.7
10.7
344
2476
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
60.8
10.6
12
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.0
10.5
60
208
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
111.3
10.4
11
*
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
10.4
10
*
D11AX14
ATC
[U] tacrolimus; topical
19.1
10.3
15
8
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
9.4
9
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
15.8
9.0
14
9
S01GX08
ATC
ketotifen; ophthalmic
3.8
8.7
36
99
CKD60
NOMESCO Finland
Anterior vitrectomy
14.2
8.7
14
10
H27.0
ICD-10 Finland
Aphakia
50.5
8.7
10
*
D11AH02
ATC
pimecrolimus; topical
16.5
8.6
13
8
S01EE01
ATC
latanoprost; ophthalmic
3.4
8.5
39
117
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
8.0
8.4
18
23
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
8.4
213
1417
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
7.9
142
850
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.0
7.8
18
26
L04AA01
ATC
[U] ciclosporin; systemic
6.5
7.7
19
30
S01BC05
ATC
ketorolac; ophthalmic
3.8
7.7
31
84
H02AB04
ATC
methylprednisolone; systemic
1.9
7.6
108
595
S01BC03
ATC
diclofenac; ophthalmic
4.5
7.5
25
57
H20.1
ICD-10 Finland
Chronic iridocyclitis
80.7
7.4
8
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
80.7
7.4
8
*
D07AB08
ATC
desonide; topical
2.1
7.3
82
412
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
2.7
7.3
47
179
R03BA05
ATC
fluticasone; inhalant
1.8
7.2
132
795
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
8.9
7.1
14
16
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
13.9
6.9
11
8
S01AX12
ATC
[U] norfloxacin; ophthalmic
11.0
6.8
12
11
D11AX15
ATC
[U] pimecrolimus; topical
40.4
6.8
8
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
16.8
6.8
10
6
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.9
6.6
14
18
E0000UV
ATC
NA
1.5
6.5
285
2147
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.0
6.5
76
391
CGD00
NOMESCO Finland
Keratotomy for error of refraction
70.3
6.4
7
*
CDW99
NOMESCO Finland
Other operation on eyeball
70.3
6.4
7
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
70.3
6.4
7
*
CGF20
NOMESCO Finland
Suture of laceration of cornea with plastic repair of conjunctiva
70.3
6.4
7
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
6.6
6.4
15
23
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.2
6.3
22
53
H57.1
ICD-10 Finland
Ocular pain
3.6
6.3
26
73
S01EB01
ATC
pilocarpine; ophthalmic
18.2
6.3
9
5
CGE10
NOMESCO Finland
Keratectomy
+∞
6.3
6
*
37108
ICD-8 Finland
Corneal opacity, Alia definita
+∞
6.3
6
*
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
+∞
6.3
6
*
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
+∞
6.3
6
*
Z96.7
ICD-10 Finland
Presence of other bone and tendon implants
+∞
6.3
6
*
B00.5
ICD-10 Finland
Herpesviral ocular disease
+∞
6.3
6
*
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
6.3
6
*
37102
ICD-8 Finland
Corneal opacity, Dystrophia corneae hereditaria
+∞
6.3
6
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
6.3
6
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
6.3
6
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
6.1
26
75
L04AD01
ATC
ciclosporin; systemic
4.1
6.1
22
55
E000002
ATC
NA
1.9
6.0
90
505
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
370
2828
1.51
8.29
5.0
5.1
36.5
36.5
g/l
0.02
340
2651
316
2511
1.39
5.17
1.9
1.8
91.6
97.4
pmol/l
1.36
173
1347
735
6708
1.46
5.11
4.8
4.3
1.9
2.0
mu/l
0.28
673
6230
23
85
2.75
4.70
1.8
1.2
—
—
—
0
0
814
7632
1.53
4.46
15.2
13.4
139.7
139.7
mmol/l
0.09
799
7440
816
7664
1.53
4.33
15.4
13.5
4.0
4.0
mmol/l
0.08
802
7459
37
185
2.04
3.93
1.6
1.8
—
—
—
0
0
197
1516
1.38
3.76
2.4
2.1
3.1
3.0
mg/l
0.22
165
1311
71
444
1.65
3.71
4.8
4.2
103.3
81.7
ng/l
1.07
64
401
606
5494
1.30
3.45
4.2
3.7
14.7
14.7
pmol/l
0.04
557
5057
135
988
1.43
3.44
1.7
1.6
1135.8
1175.1
nmol/l
0.17
100
753
606
5502
1.29
3.37
7.4
7.5
77.5
77.1
u/l
0.08
577
5216
14
48
2.95
3.31
1.6
1.2
—
—
—
0
0
64
406
1.62
3.19
3.1
3.6
4.7
4.7
pmol/l
0.09
55
366
230
1865
1.31
3.06
2.7
2.6
368.7
5741.5
umol/l
5.72
207
1674
332
2832
1.27
2.96
2.5
2.2
71.1
74.2
nmol/l
1.29
294
2591
239
1956
1.30
2.96
4.1
4.1
12.4
9.3
mg/mmol
0.35
159
1273
96
680
1.46
2.92
3.3
3.0
—
—
—
0
0
177
1392
1.34
2.91
1.5
1.5
19.8
20.2
nmol/l
0.15
154
1206
26
130
2.03
2.83
1.7
2.2
141.8
133.9
g/l
0.62
18
94
163
1272
1.34
2.82
1.7
1.6
411.9
28428215.9
pmol/l
1.23
141
1094
797
7585
1.35
2.69
13.3
12.1
22.2
22.7
mg/l
0.15
645
5884
31
169
1.86
2.65
1.2
1.4
—
—
—
0
0
131
998
1.36
2.65
2.6
2.4
14.3
13.9
umol/l
0.14
119
926
59
386
1.56
2.63
1.3
1.4
—
—
—
0
0
728
6854
1.29
2.57
5.4
5.0
39.9
39.1
mmol/mol
1.26
681
6476
169
1348
1.31
2.51
2.6
2.4
5.0
5.4
e6/l
0.16
149
1196
332
2878
1.24
2.49
7.7
6.1
1.2
1.2
mmol/l
0.41
299
2639
852
8227
1.42
2.35
10.2
9.4
32.0
29.6
u/l
1.05
831
8002
262
2228
1.24
2.31
2.6
2.6
55.4
57.4
u/l
0.24
242
2098
449
4044
1.21
2.26
5.4
4.7
6.8
6.7
mmol/l
0.61
412
3780
410
3662
1.21
2.24
5.9
6.5
11.1
11.7
umol/l
0.49
386
3487
30
172
1.77
2.23
1.1
1.1
8.6
2.3
u/ml
0.62
16
76
26
143
1.84
2.20
1.9
4.0
57.8
58.0
%
0.02
26
143
13
54
2.43
2.20
1.4
1.1
—
—
—
0
0
255
2174
1.24
2.19
2.9
3.4
2.4
2.4
mmol/l
0.28
225
1946
112
864
1.34
2.11
7.9
6.1
1.0
1.0
mmol/l
0.12
107
816
349
3082
1.21
2.11
3.0
2.7
119.7
127.4
ug/l
0.29
313
2881
5
10
5.02
2.07
1.2
1.0
—
—
—
0
0
131
1037
1.31
2.07
3.1
2.8
1.9
1.9
e6/l
0.01
70
545
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
184
1.71
2.06
3.5
3.0
0.4
0.3
u/ml
0.74
16
95
6
15
4.02
2.04
1.3
1.0
—
—
—
0
0
360
3200
1.20
2.02
8.5
6.7
1.2
1.2
mmol/l
0.59
309
2742
24
133
1.83
2.01
1.0
1.1
31.4
2.3
u/ml
0.60
13
52
25
141
1.79
1.98
1.9
3.6
4.3
4.3
e9/l
0.01
25
141
16
77
2.10
1.97
2.2
1.3
—
—
—
0
0
247
2126
1.22
1.91
3.3
3.3
8.0
8.3
mmol/l
0.31
214
1817
16
78
2.07
1.91
1.0
1.3
—
—
—
0
0
806
7759
1.29
1.91
4.6
4.4
2.8
2.9
mmol/l
0.44
747
7284
21
114
1.86
1.88
1.3
2.4
17.6
17.0
%
0.18
14
65
63
454
1.42
1.83
2.5
2.9
277.8
145.1
ng/l
0.46
55
404
749
7166
1.23
1.76
12.5
10.9
87.4
87.6
ml/min/173m2
0.10
624
5864
213
1821
1.22
1.76
3.1
2.9
0.4
0.4
e6/l
0.09
163
1359
568
5305
1.18
1.71
3.9
3.8
10.4
10.2
mm/h
0.18
525
4953
457
4196
1.18
1.68
9.4
9.4
4.1
4.0
e9/l
0.20
412
3676
135
1106
1.26
1.65
2.6
3.0
2.4
2.4
mmol/l
0.09
116
978
31
197
1.59
1.64
1.3
1.1
—
—
—
0
0
791
7634
1.24
1.58
4.1
4.0
1.4
1.4
mmol/l
4.37
735
7180
50
357
1.42
1.56
1.9
1.8
—
—
—
0
0
31
200
1.57
1.55
1.3
1.3
—
—
—
0
0
66
495
1.36
1.55
1.3
1.3
1682.3
191.5
u/ml
1.81
59
460
13
64
2.05
1.54
1.2
1.4
45683.7
54065.9
e6/l
—
7
45
92
726
1.30
1.53
21.4
18.7
1.1
1.2
inr
2.51
12
111
793
7669
1.23
1.46
4.2
4.0
4.7
4.7
mmol/l
1.17
736
7235
268
2379
1.18
1.46
3.6
3.0
—
—
—
0
0
752
7239
1.20
1.43
4.3
4.0
6.0
5.9
mmol/l
0.81
700
6718
18
103
1.76
1.41
1.1
1.2
—
—
—
0
0
764
7373
1.20
1.37
3.8
3.6
1.5
1.3
mmol/l
3.83
705
6915
12
61
1.98
1.33
2.2
1.5
1.0
1.0
g/l
0.08
12
61
20
122
1.65
1.28
1.1
1.1
16.5
3.6
u/ml
1.19
13
51
33
228
1.46
1.25
2.0
1.8
—
—
—
0
0
681
6528
1.16
1.24
16.7
14.6
13.6
13.5
%
0.30
669
6399
470
4394
1.14
1.22
4.4
3.8
114.1
1397.0
e6/l
—
8
58
111
924
1.23
1.21
2.7
2.4
2.4
2.4
g/l
0.10
103
861
888
8734
1.37
1.20
20.0
17.6
139.1
139.6
g/l
0.46
880
8634
64
501
1.30
1.17
1.2
1.2
86.2
153.5
iu/ml
1.00
19
205
377
3486
1.14
1.14
3.4
3.2
0.0
0.0
estimate
0.00
70
624
23
151
1.54
1.12
1.0
1.1
10.5
4.0
u/ml
0.66
11
41
23
151
1.54
1.12
1.7
1.6
—
—
—
0
0
41
303
1.37
1.11
1.5
1.5
296.1
266.5
mu/l
0.33
36
279
7
31
2.27
1.10
1.4
1.7
—
—
—
0
0
373
3453
1.13
1.10
3.4
3.2
0.0
0.0
estimate
0.00
75
644
23
152
1.53
1.09
1.4
1.7
3411.7
15129.6
e6/l
2.16
14
114
18
112
1.62
1.09
1.1
1.1
—
—
—
0
0
12
205
0.58
1.07
2.0
1.5
—
—
—
0
0
21
138
1.53
1.03
2.0
1.6
—
—
—
0
0
9
47
1.92
1.02
1.2
3.1
—
—
—
0
0
10
53
1.90
1.01
1.0
1.1
1.1
1.1
u/l
—
5
31
12
201
0.59
1.01
1.8
1.5
—
—
—
0
0
9
49
1.84
0.98
1.7
1.8
—
—
—
0
0
7
37
1.90
0.94
2.4
1.4
—
—
—
0
0
7
37
1.90
0.94
2.4
1.4
—
—
—
0
0
181
1613
1.15
0.94
1.7
1.8
1.5
1.0
mg/l
0.71
138
1203
101
860
1.20
0.92
2.9
2.4
21.8
24.2
%
1.09
88
744
45
350
1.30
0.90
1.3
1.4
30.8
24.5
iu/l
0.58
38
303
279
2565
1.13
0.90
3.4
3.4
35.4
33.5
u/l
0.16
267
2442
142
1250
1.16
0.87
4.0
3.6
1197.2
643.9
ng/l
0.27
104
907
6
30
2.01
0.87
1.0
1.0
—
—
—
0
0
130
1479
0.86
0.87
2.6
2.5
0.7
0.7
ug/l
0.08
67
832
116
1006
1.17
0.86
1.9
1.9
—
—
—
0
0
369
3456
1.11
0.85
4.6
4.3
0.0
0.0
estimate
0.50
76
661
52
416
1.26
0.85
3.7
3.2
5.1
5.1
kpa
0.01
45
390
127
1112
1.16
0.84
2.5
2.6
0.8
1.1
e6/l
0.50
67
621
192
1734
1.14
0.83
1.3
1.2
2.6
1.8
u/ml
0.24
70
491
12
189
0.63
0.82
1.8
1.4
—
—
—
0
0
12
189
0.63
0.82
1.8
1.4
—
—
—
0
0
49
392
1.26
0.81
3.7
3.3
1.4
1.8
mmol/l
0.32
31
289
12
188
0.63
0.80
1.8
1.4
—
—
—
0
0
12
188
0.63
0.80
1.8
1.4
—
—
—
0
0
175
1576
1.14
0.79
1.6
1.5
—
—
—
0
0
580
5580
1.10
0.77
3.5
3.1
46.6
47.8
u/l
0.16
550
5300
10
59
1.70
0.76
1.1
1.8
—
—
—
0
0
44
351
1.27
0.76
1.7
1.7
—
—
—
0
0
29
218
1.34
0.76
1.1
1.1
—
—
—
0
0
18
124
1.46
0.75
1.3
1.1
—
—
—
0
0
11
67
1.65
0.75
3.1
2.0
—
—
—
0
0
32
245
1.32
0.74
2.8
2.0
—
—
—
0
0
29
219
1.33
0.74
1.1
1.1
—
—
—
0
0
7
38
1.85
0.73
1.4
1.4
6.3
6.3
mmol/l
—
7
38
5
25
2.01
0.72
5.4
2.3
—
—
—
0
0
5
25
2.01
0.72
5.4
2.3
—
—
—
0
0
5
25
2.01
0.72
1.4
2.4
—
—
—
0
0
5
25
2.01
0.72
1.2
1.2
8.4
8.8
ug/l
—
5
25
5
25
2.01
0.72
5.4
2.3
—
—
—
0
0
19
264
0.71
0.72
1.8
1.7
—
—
—
0
0
12
76
1.59
0.72
2.1
2.0
31.3
33.5
pg
0.58
12
76
266
2471
1.11
0.71
3.5
3.8
1.5
1.9
ug/l
1.41
241
2275
7
41
1.71
0.70
1.0
1.1
20.0
27.5
u/l
—
7
33
28
213
1.32
0.69
1.4
1.4
—
—
—
0
0
27
205
1.33
0.67
1.1
1.3
827.7
491.0
mg/l
0.51
27
194
5
92
0.54
0.67
1.0
1.4
—
0.5
nmol/l
—
0
6
5
92
0.54
0.67
1.2
1.5
—
—
—
0
0
5
93
0.54
0.67
1.0
1.4
0.5
0.6
nmol/l
—
5
87
14
94
1.50
0.67
1.3
1.6
—
—
—
0
0
14
94
1.50
0.67
1.3
1.6
—
—
—
0
0
5
28
1.79
0.66
2.6
3.2
—
921.8
—
0
5
14
95
1.48
0.64
1.3
1.6
—
—
—
0
0
175
1600
1.12
0.63
2.7
3.1
1376.9
941.0
ng/l
0.75
146
1316
14
96
1.47
0.61
1.3
1.6
—
—
—
0
0
14
96
1.47
0.61
1.3
1.6
—
—
—
0
0
14
96
1.47
0.61
1.3
1.5
—
—
—
0
0
8
50
1.61
0.61
3.6
3.0
—
—
—
0
0
8
50
1.61
0.61
1.1
1.2
—
—
—
0
0
8
50
1.61
0.61
1.1
1.2
—
—
—
0
0
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
56
474
1.19
0.59
4.1
4.3
1.2
1.2
mmol/l
0.39
47
409
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
10
64
1.57
0.58
1.2
1.8
—
—
—
0
0
70
606
1.17
0.58
4.3
3.7
1.7
2.0
mmol/l
0.19
57
495
6
35
1.72
0.57
2.7
1.4
—
—
—
0
0
6
35
1.72
0.57
2.7
1.4
—
—
—
0
0
6
37
1.63
0.55
1.2
1.1
—
—
—
0
0
83
734
1.14
0.53
9.2
8.1
2.0
1.1
mmol/l
1.35
62
599
70
612
1.16
0.52
4.3
3.6
5.9
5.9
kpa
0.00
65
597
9
64
1.41
0.51
2.3
2.7
—
—
—
0
0
79
698
1.14
0.51
1.4
1.8
—
—
—
0
0
83
736
1.14
0.51
9.3
8.1
12.2
12.7
kpa
0.35
78
711
178
1650
1.10
0.51
2.2
2.2
—
—
—
0
0
80
708
1.14
0.51
1.5
1.8
—
—
—
0
0
96
1068
0.89
0.50
1.7
1.9
—
—
—
0
0
6
41
1.47
0.50
1.5
3.7
399.3
772.7
u/ml
—
6
41
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
18
137
1.32
0.47
1.8
1.7
—
—
—
0
0
129
1182
1.11
0.47
1.2
1.3
10.5
11.5
u/ml
0.06
52
481
7
48
1.46
0.47
1.3
2.2
—
—
—
0
0
746
7331
1.09
0.46
14.5
12.5
41.2
41.2
%
0.01
561
5770
13
94
1.39
0.46
1.1
1.1
—
—
—
0
0
18
138
1.31
0.45
2.2
3.5
—
2406.8
—
0
12
11
77
1.43
0.45
3.1
1.9
—
—
—
0
0
21
165
1.28
0.45
2.4
2.5
27.8
108.5
ug/min
1.67
14
104
108
1181
0.90
0.43
1.9
2.0
—
—
—
0
0
21
166
1.27
0.43
1.2
1.4
—
—
—
0
0
28
230
1.22
0.43
1.8
2.2
7.3
7.4
g/l
0.17
19
182
28
230
1.22
0.43
1.8
2.2
4.1
3.9
g/l
0.34
18
171
28
230
1.22
0.43
1.8
2.2
—
—
—
0
0
74
662
1.13
0.42
2.4
2.1
353.3
364.9
nmol/l
0.18
65
624
22
176
1.26
0.42
4.3
3.9
44.7
87.8
mg/l
0.60
16
144
28
337
0.83
0.41
1.7
1.5
—
—
—
0
0
27
222
1.22
0.41
1.7
2.2
372.1
299.9
ug/l
0.13
27
212
34
287
1.19
0.40
1.5
1.3
321.4
232.8
miu/ml
0.48
13
140
11
149
0.74
0.40
1.6
3.5
48.5
21.3
mg/l
—
6
95
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
73
811
0.89
0.40
4.2
4.1
29.6
30.7
%
0.32
52
568
13
97
1.35
0.39
1.1
1.1
—
—
—
0
0
87
790
1.11
0.39
6.3
6.2
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
71.6
12.2
u/l
—
5
28
0
19
0.00
0.39
0.0
1.2
—
338.5
—
0
13
21
169
1.25
0.39
1.5
1.5
82.5
106.0
u/ml
—
6
30
5
36
1.39
0.38
5.4
2.0
—
—
—
0
0
5
36
1.39
0.38
5.4
2.0
—
—
—
0
0
5
36
1.39
0.38
1.4
1.1
1301.4
1622.1
miu/ml
—
5
36
5
36
1.39
0.38
5.4
2.0
—
—
—
0
0
5
36
1.39
0.38
5.4
2.0
—
—
—
0
0
79
716
1.11
0.37
4.0
4.6
227.8
252.5
u/l
1.05
73
682
21
170
1.24
0.37
1.5
1.2
—
—
—
0
0
93
851
1.10
0.37
2.2
2.2
13.1
14.1
nmol/l
0.64
80
791
9
69
1.31
0.37
1.0
1.0
—
—
—
0
0
5
37
1.35
0.37
1.2
1.2
174.2
73.6
u/l
—
5
31
191
1805
1.07
0.36
3.9
3.5
0.0
0.0
estimate
1.08
71
641
5
76
0.66
0.36
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
31
264
1.18
0.35
2.5
2.5
2965.7
4160.1
u/l
0.18
11
113
18
222
0.81
0.35
1.5
1.5
—
—
—
0
0
10
73
1.37
0.34
1.0
1.0
297.4
284.9
mg/l
—
10
66
134
1254
1.08
0.34
1.2
1.3
21.3
31.7
iu/ml
0.68
38
383
29
338
0.85
0.32
3.6
2.5
1.1
1.3
%
0.88
29
338
7
52
1.35
0.31
1.0
1.0
—
—
—
0
0
7
97
0.72
0.31
1.4
3.2
106.6
18.8
u/ml
—
7
97
7
53
1.32
0.31
1.4
2.4
0.2
0.2
e9/l
—
7
45
7
53
1.32
0.31
1.0
1.6
—
—
—
0
0
7
54
1.30
0.30
1.0
1.2
—
81.8
—
0
6
7
54
1.30
0.30
1.4
2.3
470.1
666.5
e6/l
—
7
45
7
56
1.25
0.29
1.1
1.1
—
—
—
0
0
264
2541
1.05
0.29
3.1
3.2
63.2
39.8
ng/l
0.33
157
1588
21
176
1.20
0.29
4.5
3.9
31.8
32.5
mg/l
0.04
16
145
11
85
1.30
0.28
1.0
1.1
—
—
—
0
0
22
186
1.19
0.28
8.2
5.7
407.0
344.4
iu/ml
—
6
25
48
532
0.90
0.28
1.8
2.0
—
—
—
0
0
92
987
0.92
0.27
2.0
1.7
—
—
—
0
0
8
64
1.25
0.27
1.4
2.1
—
—
—
0
0
16
131
1.23
0.27
1.7
1.5
—
—
—
0
0
203
1947
1.05
0.26
1.8
1.6
1.5
1.5
mmol/l
0.07
171
1677
15
123
1.22
0.25
1.7
1.9
12.9
13.1
%
0.44
15
123
28
246
1.14
0.24
1.1
1.1
5.3
6.6
u/ml
—
6
36
25
218
1.15
0.23
1.9
2.2
3.3
3.1
g/l
0.34
19
175
5
39
1.28
0.23
1.2
1.7
—
—
—
0
0
94
997
0.94
0.22
1.5
1.4
—
—
—
0
0
207
1996
1.05
0.22
2.2
2.1
230.3
207.6
u/l
0.18
199
1905
50
459
1.09
0.21
1.4
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
14
117
1.20
0.20
2.6
1.9
—
—
—
0
0
15
127
1.18
0.19
1.2
1.1
—
10.2
—
0
14
280
2727
1.04
0.19
3.6
3.2
—
—
—
0
0
10
81
1.24
0.19
8.9
14.4
822.0
771.7
nmol/l
—
10
76
17
195
0.87
0.17
1.3
1.2
—
—
—
0
0
37
403
0.91
0.17
1.0
1.1
—
—
—
0
0
14
120
1.17
0.16
1.2
1.7
—
—
—
0
0
566
5593
1.03
0.16
3.2
3.2
—
—
—
0
0
21
187
1.13
0.16
1.0
1.2
—
3.2
—
0
6
19
168
1.13
0.15
2.3
1.8
—
—
—
0
0
6
76
0.79
0.15
1.7
1.4
—
—
—
0
0
23
207
1.11
0.15
2.2
3.4
—
—
—
0
0
9
82
1.10
0.15
1.1
1.9
—
—
—
0
0
324
3300
0.97
0.14
4.0
3.9
—
—
—
0
0
39
419
0.93
0.14
1.8
2.0
—
—
—
0
0
42
392
1.07
0.14
2.5
1.8
33.8
36.8
nmol/l
0.40
42
382
20
180
1.11
0.13
2.0
1.9
3.4
5.4
iu/l
—
5
64
15
133
1.13
0.12
1.0
1.2
—
7.5
—
0
12
17
189
0.90
0.12
1.5
1.2
315.3
238.6
u/ml
0.48
12
117
14
157
0.89
0.11
1.2
1.3
—
—
—
0
0
132
1285
1.03
0.10
1.7
1.9
1.3
1.5
%
3.61
121
1156
194
1979
0.98
0.10
3.4
3.5
24.3
20.9
%
1.52
66
763
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
61
586
1.04
0.09
3.9
4.8
7.1
30.6
ug/l
0.96
51
483
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
12
107
1.12
0.08
1.1
1.3
—
—
—
0
0
5
63
0.79
0.08
5.4
1.8
—
—
—
0
0
5
63
0.79
0.08
1.0
1.9
—
—
—
0
0
5
63
0.79
0.08
5.4
1.8
—
—
—
0
0
5
63
0.79
0.08
5.4
1.8
—
—
—
0
0
7
64
1.09
0.08
22.0
11.6
0.6
0.6
mmol/l
—
7
59
72
698
1.03
0.07
2.5
2.6
41.7
106.0
u/l
0.47
61
614
6
75
0.80
0.07
1.7
1.3
—
—
—
0
0
18
167
1.08
0.07
1.9
1.6
—
—
—
0
0
51
528
0.96
0.06
2.0
2.3
7.6
8.2
ug/l
0.12
43
481
12
109
1.10
0.06
1.2
1.4
29.8
68.3
pmol/l
—
5
34
11
121
0.91
0.06
1.0
1.1
—
—
—
0
0
12
110
1.09
0.05
1.3
2.3
—
1340.0
—
0
8
14
130
1.08
0.04
1.3
1.3
—
—
—
0
0
14
130
1.08
0.04
1.3
1.3
—
—
—
0
0
11
101
1.09
0.04
1.3
1.6
—
—
—
0
0
12
128
0.94
0.02
1.2
1.2
1.6
5.4
u/ml
—
5
56
14
132
1.06
0.02
1.1
1.2
1.8
4.1
u/ml
—
5
42
31
319
0.97
0.02
1.4
1.4
—
—
—
0
0
14
133
1.05
0.01
1.1
1.1
—
—
—
0
0
151
1520
0.99
0.01
4.0
3.4
1.0
1.0
kg/l
1.32
19
196
42
412
1.02
0.01
1.1
1.3
—
—
—
0
0
18
173
1.04
0.01
2.3
1.8
—
—
—
0
0
57
563
1.01
0.01
2.9
2.5
70.9
73.8
ml/min/173m2
0.21
28
230
35
346
1.01
0.00
1.7
1.8
4.8
3.8
mg/l
0.26
23
235
10
102
0.98
0.00
1.3
1.7
—
—
—
0
0
14
138
1.01
0.00
1.3
1.8
—
—
—
0
0
16
159
1.01
0.00
1.5
1.5
—
—
—
0
0
12
119
1.01
0.00
1.3
1.5
—
—
—
0
0
22
225
0.98
0.00
2.2
1.8
—
—
—
0
0
19
195
0.97
0.00
1.5
1.5
325.5
295.2
ug/g
—
9
116
5
52
0.96
0.00
1.2
7.9
—
66.3
—
0
19
6
61
0.98
0.00
3.3
4.1
—
—
—
0
0
9
89
1.01
0.00
1.3
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
0.3
—
0
8
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
12.8
—
0
9
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.2
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.3
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
54
0.93
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
9
90
1.00
0.00
1.3
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALDEFORM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDEFORM | 1.128 [0.92, 1.38] | 0.242 |
| Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 1933 females with H7_CORNEALDEFORM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDEFORM | 1.021 [0.86, 1.21] | 0.808 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 4002 males with H7_CORNEALDEFORM died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALDEFORM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.207% |
| 5 | 0.733% | 1.187% |
| 10 | 1.729% | 2.947% |
| 15 | 3.295% | 5.608% |
| 20 | 5.82% | 9.48% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALDEFORM – Keratoconus
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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