No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
288 |
4. Check minimum number of eventsNone |
288 |
5. Include endpointsNone |
288 |
6. Filter based on genotype QC (FinnGen only) |
288 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Keratopathia bullosa
Similar endpoints
↥List of similar endpoints to
Bullous keratopathy
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2359 | 1387 | 961 |
| Only index persons | 2101 | 1236 | 865 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.68 | 76.86 | 69.05 |
| Only index persons | 72.48 | 75.69 | 67.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 288 | 165 | 123 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | 70.80 | 70.96 | 70.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
323.0
248
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
87.8
79
*
H16.0
ICD-10 Finland
Corneal ulcer
315.2
87.6
84
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.5
64.0
153
305
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
63.3
58
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
14.1
62.8
218
841
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
731.2
60.4
57
*
S01ED01
ATC
timolol; ophthalmic
21.4
58.6
90
64
TCG10
NOMESCO Finland
Removal of sutures from cornea
319.1
52.2
51
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
8.3
48.2
196
774
S01EC01
ATC
acetazolamide; systemic
35.5
48.1
62
23
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
45.2
42
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
26.8
45.2
63
31
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
44.1
41
*
S01ED51
ATC
timolol, combinations; ophthalmic
10.3
42.8
94
139
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
40.8
38
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
40.8
38
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
54.6
38.4
45
10
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
37.4
35
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
36.3
34
*
WX140
NOMESCO Finland
Parabulbar anesthesy
13.4
36.2
66
65
114
Kela drug reimbursment
Glaucoma
7.2
34.3
97
204
H18.2
ICD-10 Finland
Other corneal oedema
+∞
30.9
29
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.9
29.9
84
170
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
29.8
28
*
S01EE01
ATC
latanoprost; ophthalmic
7.3
26.8
70
126
CG2S4
NOMESCO Finland
Photography of cornea
289.0
26.2
26
*
S01EA03
ATC
apraclonidine; ophthalmic
36.5
25.3
32
10
H18.6
ICD-10 Finland
Keratoconus
276.6
25.1
25
*
S01EX03
ATC
NA
13.5
24.9
44
39
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
15.1
23.9
40
31
XCK00
NOMESCO Finland
Perimetry
8.3
23.6
55
82
XCK10
NOMESCO Finland
Photography of fundus of eye
5.7
23.4
75
174
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
23.3
22
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
13.4
23.2
41
36
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.9
22.9
163
815
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.0
20.9
77
206
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
20.3
84
253
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
20.1
19
*
S01EC03
ATC
dorzolamide; ophthalmic
16.5
20.0
32
22
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
216.5
19.9
20
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.8
19.3
46
70
CKD60
NOMESCO Finland
Anterior vitrectomy
30.7
19.1
25
9
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
19.0
18
*
S01BC03
ATC
diclofenac; ophthalmic
11.2
18.9
36
37
S01EE04
ATC
travoprost; ophthalmic
13.4
18.4
32
27
S01EC04
ATC
brinzolamide; ophthalmic
7.9
18.3
43
64
H04.10
ICD-10 Finland
Dry eye syndrome
5.9
17.5
52
107
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
17.6
17.5
27
17
S01AD03
ATC
aciclovir; ophthalmic
9.0
16.8
36
46
H33.0
ICD-10 Finland
Retinal detachment with retinal break
11.0
16.8
32
33
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
16.9
16.6
26
17
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
43.3
16.6
20
5
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
15.8
15
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
170.2
15.7
16
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.9
15.3
54
134
H27.0
ICD-10 Finland
Aphakia
85.2
14.7
16
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
14.7
14
*
ZXA05
NOMESCO Finland
Left side
3.1
14.7
106
478
XCH00
NOMESCO Finland
Eye pressure measurement
9.3
14.5
30
36
CHD99
NOMESCO Finland
Other filtering operation
73.7
12.7
14
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
6.2
12.5
34
62
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
12.3
121
648
H40.0
ICD-10 Finland
Glaucoma suspect
4.6
12.1
43
107
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
11.4
12.0
22
21
S01AX11
ATC
[U] ofloxacin; ophthalmic
6.8
12.0
30
49
CGF10
NOMESCO Finland
Suture of laceration of cornea
68.2
11.7
13
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
11.5
11
*
3604
FHL
Penetration of the cornea
+∞
11.5
11
*
S01EA02
ATC
dipivefrine; ophthalmic
36.9
11.4
14
*
S01EB01
ATC
pilocarpine; ophthalmic
18.1
11.4
17
10
S01EE05
ATC
tafluprost; ophthalmic
6.2
10.8
29
52
CFD10
NOMESCO Finland
Repair of conjunctiva
114.6
10.5
11
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
10.5
10
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
10.5
10
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
10.5
10
*
S01ED02
ATC
betaxolol; ophthalmic
10.2
10.5
20
21
S01FA04
ATC
cyclopentolate; ophthalmic
24.6
10.4
14
6
WX002
NOMESCO Finland
Sedation and analgesia
2.8
10.2
77
341
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
10.1
56
204
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.9
10.1
12
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
41.9
10.1
12
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
57.3
9.7
11
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
103.8
9.5
10
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
103.8
9.5
10
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
9.4
9
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
9.4
9
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
9.4
9
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
+∞
9.4
9
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
9.4
9
*
H57.1
ICD-10 Finland
Ocular pain
8.8
9.3
19
23
ZXA00
NOMESCO Finland
Right side
2.4
9.0
98
527
ZXA10
NOMESCO Finland
Bilateral
2.6
8.8
74
347
CHC05
NOMESCO Finland
Iridotomy
12.2
8.7
15
13
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
28.6
8.6
11
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
93.1
8.5
9
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
8.4
8
*
S01KA02
ATC
hypromellose; ophthalmic
10.6
8.1
15
15
H26.4
ICD-10 Finland
After-cataract
2.8
8.1
56
235
S01EE03
ATC
bimatoprost; ophthalmic
6.1
8.0
21
37
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
15.7
7.8
12
8
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
46.4
7.8
9
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
46.4
7.8
9
*
S01FA01
ATC
atropine; ophthalmic
13.9
7.5
12
9
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
13.9
7.5
12
9
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
82.4
7.5
8
*
37401
ICD-8 Finland
Cataract, Praesenilis
82.4
7.5
8
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
+∞
7.3
7
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
7.3
7
*
H16.8
ICD-10 Finland
Other keratitis
+∞
7.3
7
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
7.3
7
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
7.3
7
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.0
7.2
22
47
3661A
ICD-9 Finland
Cataract, Senile cataract
8.3
7.2
15
19
H27.1
ICD-10 Finland
Dislocation of lens
14.3
7.0
11
8
H40.9
ICD-10 Finland
Glaucoma, unspecified
7.0
6.9
16
24
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
41.2
6.8
8
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
41.2
6.8
8
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
41.2
6.8
8
*
H26.2
ICD-10 Finland
Complicated cataract
12.7
6.6
11
9
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
12.7
6.6
11
9
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.2
6.6
15
22
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
71.6
6.5
7
*
L04AA01
ATC
[U] ciclosporin; systemic
11.4
6.4
11
10
S01AA12
ATC
tobramycin; ophthalmic
18.6
6.3
9
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
18.6
6.3
9
5
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
6.3
6
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
6.3
6
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
6.3
6
*
CHD10
NOMESCO Finland
Trabeculectomy
+∞
6.3
6
*
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
6.3
6
*
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
6.3
6
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
6.2
42
170
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
6.2
27
82
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.0
6.2
23
61
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
13
9.59
9.94
1.4
1.5
—
—
—
0
0
8
8
10.24
4.54
1.0
1.3
—
—
—
0
0
20
77
2.72
3.90
2.1
2.9
—
—
—
0
0
250
2246
1.86
3.20
20.9
19.2
139.4
139.5
mmol/l
0.22
244
2183
250
2253
1.83
3.06
21.0
19.3
4.0
4.0
mmol/l
0.95
244
2190
68
457
1.64
2.99
1.9
1.7
1.7
1.3
mg/l
0.27
53
371
240
2143
1.72
2.97
18.5
16.1
24.8
23.7
mg/l
0.21
212
1749
87
630
1.55
2.78
2.4
2.2
3.5
3.3
mg/l
0.39
78
533
139
1118
1.47
2.66
4.0
4.3
0.0
0.0
estimate
0.50
20
201
166
1388
1.46
2.56
4.5
4.4
7.0
6.9
mmol/l
0.16
156
1300
5
7
7.24
2.56
1.0
1.1
—
—
—
0
0
188
1617
1.47
2.46
4.2
4.1
13.7
14.4
mm/h
0.25
164
1468
136
1107
1.43
2.36
5.1
5.8
0.0
0.0
estimate
0.00
21
198
9
28
3.28
2.32
1.1
1.1
—
—
—
0
0
135
1103
1.42
2.27
3.8
4.4
0.0
0.0
estimate
0.00
22
209
9
29
3.17
2.24
1.3
1.4
—
—
—
0
0
219
1960
1.49
2.19
5.2
4.9
2.1
2.0
mu/l
0.30
192
1745
111
880
1.43
2.19
4.1
4.7
—
—
—
0
0
179
1546
1.42
2.15
5.4
5.3
637.2
2862.5
e6/l
—
5
42
94
726
1.44
2.13
2.4
2.5
54.7
56.4
u/l
0.26
83
674
88
672
1.45
2.11
3.0
2.7
31.9
31.2
u/l
0.10
80
640
245
2256
1.58
2.03
10.7
10.4
22.9
23.8
u/l
0.54
230
2166
186
1627
1.40
2.01
4.4
4.0
15.3
15.1
pmol/l
0.42
163
1446
7
21
3.39
1.97
2.7
2.2
—
—
—
0
0
195
1723
1.41
1.96
6.8
7.0
80.5
80.2
u/l
0.03
176
1602
205
1837
1.40
1.83
18.8
17.1
37.4
39.0
%
0.87
120
1195
7
24
2.96
1.73
2.1
7.7
—
146.8
—
0
5
5
13
3.89
1.72
1.0
1.2
—
—
—
0
0
5
14
3.61
1.62
1.2
1.1
—
—
—
0
0
106
871
1.34
1.59
3.3
3.4
—
—
—
0
0
42
293
1.51
1.58
8.8
8.6
—
—
—
0
0
119
998
1.33
1.55
5.9
4.0
—
—
—
0
0
147
1271
1.32
1.54
7.8
7.8
4.3
4.3
e9/l
0.12
134
1119
104
856
1.34
1.54
3.1
3.3
2719.8
1428.8
ng/l
0.80
92
730
5
15
3.37
1.53
1.8
2.3
—
—
—
0
0
31
206
1.57
1.45
6.0
3.7
1.2
1.2
mmol/l
0.16
25
182
80
639
1.35
1.43
4.1
4.7
0.0
0.0
estimate
0.00
19
201
70
553
1.35
1.34
1.8
1.8
1242.7
1218.2
nmol/l
0.08
51
404
217
2008
1.33
1.26
16.2
15.4
73.2
73.0
ml/min/173m2
0.03
182
1674
6
25
2.43
1.25
1.0
1.4
331.0
251.9
u/l
—
6
25
43
318
1.41
1.22
1.3
1.3
18.5
43.3
iu/ml
2.41
19
100
217
2022
1.30
1.10
7.6
6.5
41.4
41.1
mmol/mol
0.22
191
1854
23
154
1.54
1.07
1.2
1.4
—
—
—
0
0
10
52
1.96
1.07
1.3
1.5
—
—
—
0
0
121
1061
1.24
1.02
5.4
4.3
34.5
34.9
g/l
0.35
106
979
221
2073
1.28
1.01
4.9
4.7
4.4
4.5
mmol/l
1.43
198
1885
138
1229
1.24
1.01
4.9
5.5
10.8
11.5
umol/l
0.54
125
1155
133
1182
1.23
0.98
6.0
5.9
1.2
1.2
mmol/l
0.03
109
989
212
1987
1.25
0.92
4.4
4.2
1.3
1.3
mmol/l
0.19
185
1768
6
28
2.17
0.92
1.3
1.5
—
—
—
0
0
117
1032
1.23
0.92
2.3
2.1
93.4
93.5
pmol/l
0.01
54
520
114
1003
1.23
0.91
4.3
4.2
48.7
70.1
ng/l
0.27
86
756
69
577
1.26
0.87
3.5
2.7
383.0
11065.1
umol/l
3.81
55
479
218
2055
1.25
0.87
4.8
4.7
1.5
1.5
mmol/l
0.36
193
1845
32
241
1.37
0.85
2.7
3.3
2.0
2.2
mmol/l
0.07
22
185
32
243
1.36
0.81
2.7
3.3
5.7
5.8
kpa
0.21
32
232
225
2135
1.25
0.80
5.4
5.3
2.4
2.6
mmol/l
1.96
200
1920
8
48
1.69
0.79
1.4
1.5
—
—
—
0
0
8
48
1.69
0.79
1.4
1.5
—
—
—
0
0
36
282
1.32
0.76
2.0
1.7
—
—
—
0
0
9
57
1.60
0.72
1.4
1.3
—
—
—
0
0
5
26
1.94
0.71
1.4
1.4
—
—
—
0
0
49
405
1.25
0.69
2.5
2.4
12.9
12.3
umol/l
0.22
42
364
33
259
1.31
0.69
4.5
3.6
—
—
—
0
0
67
574
1.22
0.69
1.9
1.8
109259709.7
435.8
pmol/l
0.49
54
460
219
2086
1.21
0.67
5.4
4.9
6.2
6.1
mmol/l
0.50
195
1857
79
690
1.20
0.67
5.3
5.2
2.6
2.9
ug/l
0.15
65
608
85
749
1.19
0.65
1.8
2.1
168.3
200.5
u/l
0.27
79
707
43
353
1.26
0.65
2.4
2.4
22.8
21.4
%
0.24
34
298
24
182
1.35
0.64
2.5
3.1
74.9
58.1
ml/min/173m2
1.06
11
81
45
373
1.24
0.63
2.4
2.4
2.3
2.3
g/l
0.02
40
332
76
666
1.19
0.62
3.2
3.3
0.4
0.5
e6/l
0.12
63
513
5
30
1.68
0.61
1.4
1.7
—
—
—
0
0
5
30
1.68
0.61
1.4
1.7
—
—
—
0
0
5
30
1.68
0.61
1.4
1.7
—
—
—
0
0
5
30
1.68
0.61
1.4
1.7
—
—
—
0
0
5
30
1.68
0.61
1.4
1.7
—
—
—
0
0
8
51
1.58
0.61
1.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
3.9
—
—
—
0
0
58
497
1.21
0.60
4.7
4.1
116.9
199.8
ng/l
0.38
46
430
26
202
1.32
0.60
2.9
3.6
71.7
83.3
ng/l
0.53
19
177
0
22
0.00
0.59
0.0
1.0
—
1.3
—
0
10
6
35
1.73
0.58
1.3
1.6
—
—
—
0
0
8
54
1.50
0.57
1.5
1.5
—
—
—
0
0
45
378
1.23
0.57
2.3
2.9
0.8
0.8
mmol/l
0.20
40
349
8
123
0.64
0.56
8.4
6.1
22.3
24.7
mmol/l
—
8
110
33
268
1.26
0.55
3.7
3.9
225.3
245.3
u/l
0.81
33
247
6
38
1.59
0.54
1.3
1.4
—
—
—
0
0
35
288
1.25
0.53
1.4
1.3
7.3
13.0
u/ml
0.31
17
102
63
552
1.18
0.52
4.3
4.7
19.9
21.5
%
0.44
29
268
8
117
0.67
0.47
1.7
1.7
—
—
—
0
0
21
165
1.29
0.46
4.6
5.9
24.9
24.7
mmol/l
0.05
21
157
5
84
0.59
0.46
1.0
1.9
—
—
—
0
0
5
31
1.62
0.43
1.4
1.7
—
—
—
0
0
5
31
1.62
0.43
1.6
1.4
—
—
—
0
0
6
94
0.63
0.43
1.0
2.1
—
—
—
0
0
92
843
1.13
0.42
3.7
3.1
2.3
2.4
mmol/l
1.01
78
715
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
8
59
1.37
0.41
2.3
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
33
281
1.20
0.38
2.0
1.6
—
—
—
0
0
5
37
1.36
0.37
1.6
1.4
—
—
—
0
0
20
243
0.81
0.35
1.6
1.4
—
—
—
0
0
25
209
1.21
0.35
2.3
2.5
4.9
4.2
kpa
0.62
25
198
116
1090
1.11
0.34
5.2
5.0
1.2
1.2
mmol/l
0.65
105
975
29
248
1.19
0.33
2.0
2.6
5.7
6.5
ug/l
0.16
24
220
18
146
1.25
0.33
5.0
4.0
1.8
2.3
mmol/l
0.16
13
105
11
83
1.34
0.32
1.0
2.7
0.0
0.8
g/l
1.68
11
72
18
218
0.81
0.31
4.8
4.4
1.4
1.4
mmol/l
0.07
18
203
58
527
1.13
0.31
2.2
2.2
—
—
—
0
0
71
655
1.11
0.29
1.7
1.6
19.3
20.5
nmol/l
0.25
60
541
13
103
1.27
0.28
2.9
2.4
—
—
—
0
0
99
931
1.10
0.28
2.5
2.3
80.8
77.5
nmol/l
0.56
81
811
10
76
1.33
0.28
1.0
2.4
0.0
0.0
g/l
—
10
69
21
178
1.19
0.27
1.5
1.6
—
—
—
0
0
96
905
1.09
0.26
3.4
2.8
132.1
126.6
ug/l
0.11
90
811
31
274
1.15
0.25
4.5
4.9
32.0
32.6
%
0.10
16
176
7
93
0.75
0.23
1.0
1.2
—
—
—
0
0
8
103
0.77
0.21
2.6
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
5.4
—
221.5
—
0
11
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
135
1300
1.07
0.21
2.9
3.0
59.5
52.4
u/l
0.36
122
1196
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.6
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
45
414
1.10
0.20
2.1
1.7
—
—
—
0
0
105
1093
0.94
0.18
2.6
2.5
—
—
—
0
0
51
545
0.92
0.17
1.9
1.6
1.4
1.3
mmol/l
0.10
43
446
10
82
1.23
0.17
1.2
1.2
—
—
—
0
0
8
68
1.18
0.16
1.0
2.6
0.0
0.0
g/l
—
8
63
8
70
1.15
0.16
1.0
2.6
0.0
0.0
g/l
—
8
63
15
130
1.16
0.16
1.5
2.3
1.0
1.2
%
0.78
15
130
25
226
1.12
0.15
5.3
5.8
116.1
121.6
g/l
0.73
25
218
9
108
0.83
0.13
2.4
1.9
—
—
—
0
0
38
358
1.07
0.11
27.6
28.5
1.4
1.3
inr
—
7
45
5
61
0.82
0.08
1.0
1.5
—
—
—
0
0
39
372
1.06
0.08
2.8
3.1
2.7
3.4
e6/l
0.25
26
215
41
393
1.05
0.07
2.7
2.9
0.7
1.3
e6/l
1.67
28
233
9
88
1.02
0.07
1.0
1.0
—
—
—
0
0
16
149
1.08
0.05
5.7
5.7
0.8
0.7
%
0.03
16
149
53
518
1.03
0.03
3.2
2.9
2.5
2.5
mmol/l
0.13
44
448
16
151
1.06
0.03
5.7
5.5
1.5
1.6
%
0.12
16
151
42
410
1.03
0.03
3.1
3.0
0.5
0.9
ug/l
2.89
28
268
44
430
1.03
0.03
1.3
1.2
0.7
1.5
u/ml
0.95
15
120
11
103
1.07
0.02
1.4
2.5
30.2
33.1
u/ml
0.06
11
98
24
247
0.97
0.01
1.7
2.4
10.6
8.4
umol/l
0.21
18
213
29
288
1.01
0.00
4.7
5.1
1.0
1.7
mmol/l
0.32
22
227
16
155
1.03
0.00
1.9
1.6
—
—
—
0
0
29
285
1.02
0.00
4.7
5.2
5.1
5.1
kpa
0.02
29
271
29
285
1.02
0.00
4.7
5.2
11.3
11.4
kpa
0.06
29
273
26
265
0.98
0.00
1.5
1.5
—
—
—
0
0
10
104
0.96
0.00
1.9
3.2
7.7
1749.0
u/ml
—
10
91
6
62
0.97
0.00
1.2
1.3
—
—
—
0
0
6
62
0.97
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
73
0.96
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
7
73
0.96
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
1.2
—
0
7
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
14.3
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
3.2
—
85.1
—
0
9
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
95.0
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_BULLKERATOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.232 [1.06, 1.43] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 1262 females with H7_BULLKERATOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.031 [0.86, 1.23] | 0.739 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 869 males with H7_BULLKERATOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_BULLKERATOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.201% |
| 5 | 0.61% | 1.199% |
| 10 | 1.702% | 3.042% |
| 15 | 3.265% | 5.816% |
| 20 | 6.012% | 9.836% |
Relationships between endpoints
↥Index endpoint: H7_BULLKERATOPATHY – Bullous keratopathy
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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