≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Bullous keratopathy

DOID EFO Endpoint Browser PheWeb

H7_BULLKERATOPATHY

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.1
  • Cause of death: ICD-10 — H18.1

2 out of 7 registries used, show all original rules.

288

4. Check minimum number of events

None

288

5. Include endpoints

None

288

6. Filter based on genotype QC (FinnGen only)

288

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Keratopathia bullosa

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2359 1387 961
Only index persons 2101 1236 865
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 73.68 76.86 69.05
Only index persons 72.48 75.69 67.89

-FinnGen-

Key figures

All Female Male
Number of individuals 288 165 123
Unadjusted period prevalence (%) 0.06 0.06 0.05
Median age at first event (years) 70.80 70.96 70.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
248
Matched controls
2479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
323.0
248
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
87.8
79
*
H16.0
ICD-10 Finland
Corneal ulcer
315.2
87.6
84
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.5
64.0
153
305
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
63.3
58
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
14.1
62.8
218
841
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
731.2
60.4
57
*
S01ED01
ATC
timolol; ophthalmic
21.4
58.6
90
64
TCG10
NOMESCO Finland
Removal of sutures from cornea
319.1
52.2
51
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
8.3
48.2
196
774
S01EC01
ATC
acetazolamide; systemic
35.5
48.1
62
23
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
45.2
42
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
26.8
45.2
63
31
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
44.1
41
*
S01ED51
ATC
timolol, combinations; ophthalmic
10.3
42.8
94
139
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
40.8
38
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
40.8
38
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
54.6
38.4
45
10
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
37.4
35
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
36.3
34
*
WX140
NOMESCO Finland
Parabulbar anesthesy
13.4
36.2
66
65
114
Kela drug reimbursment
Glaucoma
7.2
34.3
97
204
H18.2
ICD-10 Finland
Other corneal oedema
+∞
30.9
29
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.9
29.9
84
170
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
29.8
28
*
S01EE01
ATC
latanoprost; ophthalmic
7.3
26.8
70
126
CG2S4
NOMESCO Finland
Photography of cornea
289.0
26.2
26
*
S01EA03
ATC
apraclonidine; ophthalmic
36.5
25.3
32
10
H18.6
ICD-10 Finland
Keratoconus
276.6
25.1
25
*
S01EX03
ATC
NA
13.5
24.9
44
39
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
15.1
23.9
40
31
XCK00
NOMESCO Finland
Perimetry
8.3
23.6
55
82
XCK10
NOMESCO Finland
Photography of fundus of eye
5.7
23.4
75
174
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
23.3
22
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
13.4
23.2
41
36
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.9
22.9
163
815
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.0
20.9
77
206
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
20.3
84
253
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
20.1
19
*
S01EC03
ATC
dorzolamide; ophthalmic
16.5
20.0
32
22
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
216.5
19.9
20
*
Z3229
NOMESCO Finland
Other healthcare associate professional
5.9
19.6
59
124
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.8
19.3
46
70
CKD60
NOMESCO Finland
Anterior vitrectomy
30.7
19.1
25
9
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
19.0
18
*
S01BC03
ATC
diclofenac; ophthalmic
11.2
18.9
36
37
S01EE04
ATC
travoprost; ophthalmic
13.4
18.4
32
27
S01EC04
ATC
brinzolamide; ophthalmic
7.9
18.3
43
64
H04.10
ICD-10 Finland
Dry eye syndrome
5.9
17.5
52
107
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
17.6
17.5
27
17
S01AD03
ATC
aciclovir; ophthalmic
9.0
16.8
36
46
H33.0
ICD-10 Finland
Retinal detachment with retinal break
11.0
16.8
32
33
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
16.9
16.6
26
17
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
43.3
16.6
20
5
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
15.8
15
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
170.2
15.7
16
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.9
15.3
54
134
H27.0
ICD-10 Finland
Aphakia
85.2
14.7
16
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
14.7
14
*
ZXA05
NOMESCO Finland
Left side
3.1
14.7
106
478
XCH00
NOMESCO Finland
Eye pressure measurement
9.3
14.5
30
36
CHD99
NOMESCO Finland
Other filtering operation
73.7
12.7
14
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
6.2
12.5
34
62
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
12.3
121
648
H40.0
ICD-10 Finland
Glaucoma suspect
4.6
12.1
43
107
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
11.4
12.0
22
21
S01AX11
ATC
[U] ofloxacin; ophthalmic
6.8
12.0
30
49
CGF10
NOMESCO Finland
Suture of laceration of cornea
68.2
11.7
13
*
3604
FHL
Penetration of the cornea
+∞
11.5
11
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
11.5
11
*
S01EA02
ATC
dipivefrine; ophthalmic
36.9
11.4
14
*
S01EB01
ATC
pilocarpine; ophthalmic
18.1
11.4
17
10
S01EE05
ATC
tafluprost; ophthalmic
6.2
10.8
29
52
CFD10
NOMESCO Finland
Repair of conjunctiva
114.6
10.5
11
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
10.5
10
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
10.5
10
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
10.5
10
*
S01ED02
ATC
betaxolol; ophthalmic
10.2
10.5
20
21
S01FA04
ATC
cyclopentolate; ophthalmic
24.6
10.4
14
6
WX002
NOMESCO Finland
Sedation and analgesia
2.8
10.2
77
341
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
10.1
56
204
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.9
10.1
12
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
41.9
10.1
12
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
57.3
9.7
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
9.6
116
667
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
103.8
9.5
10
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
103.8
9.5
10
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
9.4
9
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
9.4
9
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
9.4
9
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
+∞
9.4
9
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
9.4
9
*
H57.1
ICD-10 Finland
Ocular pain
8.8
9.3
19
23
ZXA00
NOMESCO Finland
Right side
2.4
9.0
98
527
ZXA10
NOMESCO Finland
Bilateral
2.6
8.8
74
347
CHC05
NOMESCO Finland
Iridotomy
12.2
8.7
15
13
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
28.6
8.6
11
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
93.1
8.5
9
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
8.4
8
*
S01KA02
ATC
hypromellose; ophthalmic
10.6
8.1
15
15
H26.4
ICD-10 Finland
After-cataract
2.8
8.1
56
235
S01EE03
ATC
bimatoprost; ophthalmic
6.1
8.0
21
37
ZXD20
NOMESCO Finland
Day surgery
3.0
7.9
48
185
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
15.7
7.8
12
8
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
46.4
7.8
9
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
46.4
7.8
9
*
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
13.9
7.5
12
9
S01FA01
ATC
atropine; ophthalmic
13.9
7.5
12
9
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
82.4
7.5
8
*
37401
ICD-8 Finland
Cataract, Praesenilis
82.4
7.5
8
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
7.3
7
*
H16.8
ICD-10 Finland
Other keratitis
+∞
7.3
7
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
7.3
7
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
+∞
7.3
7
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
7.3
7
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.0
7.2
22
47
3661A
ICD-9 Finland
Cataract, Senile cataract
8.3
7.2
15
19
H27.1
ICD-10 Finland
Dislocation of lens
14.3
7.0
11
8
H40.9
ICD-10 Finland
Glaucoma, unspecified
7.0
6.9
16
24
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
6.9
104
635
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
41.2
6.8
8
*
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
41.2
6.8
8
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
41.2
6.8
8
*
H26.2
ICD-10 Finland
Complicated cataract
12.7
6.6
11
9
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
12.7
6.6
11
9
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.2
6.6
15
22
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
71.6
6.5
7
*
L04AA01
ATC
[U] ciclosporin; systemic
11.4
6.4
11
10
S01AA12
ATC
tobramycin; ophthalmic
18.6
6.3
9
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
18.6
6.3
9
5
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
6.3
6
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
6.3
6
*
CHD10
NOMESCO Finland
Trabeculectomy
+∞
6.3
6
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
6.3
6
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
6.3
6
*
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
6.3
6
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
6.2
42
170
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
6.2
27
82
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.0
6.2
23
61

Mortality – FinRegistry

↥

Association

Association between endpoint H7_BULLKERATOPATHY and mortality.

Females

Parameter HR [95% CI] p-value
H7_BULLKERATOPATHY 1.232 [1.06, 1.43] 0.006
Birth year 0.994 [0.99, 1.0] 0.165

During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 1262 females with H7_BULLKERATOPATHY died.

Males

Parameter HR [95% CI] p-value
H7_BULLKERATOPATHY 1.031 [0.86, 1.23] 0.739
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 869 males with H7_BULLKERATOPATHY died.

Mortality risk

Mortality risk for people of age

years, who have H7_BULLKERATOPATHY.

N-year risk Females Males
1 0.117% 0.201%
5 0.61% 1.199%
10 1.702% 3.042%
15 3.265% 5.816%
20 6.012% 9.836%

Relationships between endpoints

↥

Index endpoint: H7_BULLKERATOPATHY – Bullous keratopathy

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data