No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
306 |
4. Check minimum number of eventsNone |
306 |
5. Include endpointsNone |
306 |
6. Filter based on genotype QC (FinnGen only) |
295 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Keratopathia bullosa
Similar endpoints
↥List of similar endpoints to
Bullous keratopathy
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2359 | 1387 | 961 |
| Only index persons | 2101 | 1236 | 865 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.68 | 76.86 | 69.05 |
| Only index persons | 72.48 | 75.69 | 67.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 295 | 169 | 126 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 70.82 | 70.96 | 70.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 306
- Matched controls
- 3060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
307.7
306
*
H16.0
ICD-10 Finland
Corneal ulcer
106.3
217.0
114
17
S01ED01
ATC
timolol; ophthalmic
30.7
155.7
114
58
S01EA05
ATC
brimonidine; ophthalmic
41.3
145.2
93
32
S01EC01
ATC
acetazolamide; systemic
33.7
123.7
84
34
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.7
121.1
206
400
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
118.7
106
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
70.4
112.2
62
11
S01ED51
ATC
timolol, combinations; ophthalmic
13.2
105.9
130
162
WX140
NOMESCO Finland
Parabulbar anesthesy
15.8
95.6
95
85
114
Kela drug reimbursment
Glaucoma
9.5
81.2
131
224
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
76.3
70
*
S01EA03
ATC
apraclonidine; ophthalmic
44.9
76.0
46
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
14.6
74.3
271
1060
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
74.0
68
*
S01EX03, ,
ATC
20.8
72.2
58
34
S01EE01
ATC
latanoprost; ophthalmic
9.5
64.5
92
133
TCG10
NOMESCO Finland
Removal of sutures from cornea
724.1
62.1
59
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
8.4
60.7
244
976
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
60.4
56
*
S01EC03
ATC
dorzolamide; ophthalmic
22.2
57.3
44
23
S01BC03
ATC
diclofenac; ophthalmic
20.1
56.0
45
26
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.1
55.7
109
221
S01EC04
ATC
brinzolamide; ophthalmic
11.2
55.5
65
72
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
634.6
55.4
53
*
S01EE04
ATC
travoprost; ophthalmic
17.3
53.1
46
31
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
51.5
48
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.9
50.6
99
199
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
11.4
49.3
56
59
XCK00
NOMESCO Finland
Perimetry
8.1
49.1
77
122
CG2T4
NOMESCO Finland
Topography assessment of cornea
104.1
48.6
52
6
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
283.4
48.5
48
*
S01BA07
ATC
fluorometholone; ophthalmic
20.9
47.3
37
20
H18.2
ICD-10 Finland
Other corneal oedema
+∞
47.1
44
*
S01AD03
ATC
aciclovir; ophthalmic
13.7
46.5
46
39
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.4
42.7
114
301
S01BA04
ATC
prednisolone; ophthalmic
15.9
42.4
38
27
S01BA01
ATC
dexamethasone; ophthalmic
10.4
40.0
48
54
H16.9
ICD-10 Finland
Keratitis, unspecified
229.1
39.8
40
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
38.3
36
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.7
36.4
82
184
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
35.1
33
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
34.9
116
359
H18.8
ICD-10 Finland
Other specified disorders of cornea
376.9
34.7
34
*
S01EE05
ATC
tafluprost; ophthalmic
8.4
32.7
46
63
CG2S4
NOMESCO Finland
Photography of cornea
184.2
32.4
33
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
6.8
31.8
55
95
Z3229
NOMESCO Finland
Other healthcare associate professional
5.3
31.2
75
177
XCH00
NOMESCO Finland
Eye pressure measurement
7.3
31.0
50
80
H04.10
ICD-10 Finland
Dry eye syndrome
5.4
30.4
71
163
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.1
30.0
212
1086
H18.6
ICD-10 Finland
Keratoconus
+∞
28.6
27
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
27.5
26
*
CKD60
NOMESCO Finland
Anterior vitrectomy
27.9
27.3
37
15
H33.0
ICD-10 Finland
Retinal detachment with retinal break
8.7
27.0
36
46
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
79.6
26.3
29
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
25.4
24
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.8
23.8
61
150
S01EE03
ATC
bimatoprost; ophthalmic
8.4
23.4
32
42
H18.4
ICD-10 Finland
Corneal degeneration
+∞
22.1
21
*
S01AX11
ATC
[U] ofloxacin
6.2
21.6
40
73
H27.0
ICD-10 Finland
Aphakia
64.8
21.2
24
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
21.1
20
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
82.7
21.0
23
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.8
20.0
72
227
H57.1
ICD-10 Finland
Ocular pain
8.4
19.9
27
35
S01AA01
ATC
chloramphenicol; ophthalmic
5.4
19.1
41
86
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
18.9
18
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
32.4
18.6
24
8
S01ED02
ATC
betaxolol; ophthalmic
16.3
17.0
27
18
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
16.8
16
*
ZXA05
NOMESCO Finland
Left side
2.8
16.7
124
596
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
179.4
16.7
17
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
7.7
15.9
23
32
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
15.8
15
*
CFD10
NOMESCO Finland
Repair of conjunctiva
168.2
15.6
16
*
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
5.1
15.6
35
76
S01FA04
ATC
cyclopentolate; ophthalmic
40.3
15.6
19
5
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.7
15.3
38
90
ZXA10
NOMESCO Finland
Bilateral
2.8
15.2
101
454
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
15.1
164
941
WX002
NOMESCO Finland
Sedation and analgesia
2.8
14.8
95
419
ZXD20
NOMESCO Finland
Day surgery
3.3
14.7
66
237
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
84.2
14.7
16
*
H26.2
ICD-10 Finland
Complicated cataract
23.7
14.4
20
9
ZXC20
NOMESCO Finland
Use of chemical agents
6.8
14.3
23
36
S01EB01
ATC
pilocarpine; ophthalmic
16.8
14.2
22
14
S01EA02
ATC
dipivefrine; ophthalmic
56.0
13.9
16
*
H26.4
ICD-10 Finland
After-cataract
3.1
13.6
69
266
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
146.2
13.6
14
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
22.4
13.5
19
9
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.7
13.5
33
77
ZXA00
NOMESCO Finland
Right side
2.5
13.3
125
660
CHD99
NOMESCO Finland
Other filtering operation
29.9
13.1
17
6
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.5
12.9
26
51
CHC05
NOMESCO Finland
Iridotomy
11.7
12.8
23
21
S01EC54
ATC
brinzolamide, combinations; ophthalmic
14.0
12.6
21
16
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
12.6
12
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
12.6
12
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
12.6
12
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
135.3
12.5
13
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
28.0
12.2
16
6
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
24.0
11.7
16
7
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
11.5
11
*
3604
FHL
Penetration of the cornea
+∞
11.5
11
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
11.5
11
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
8.6
11.3
24
30
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
11.1
143
852
S01FA01
ATC
atropine; ophthalmic
29.2
10.8
14
5
H54.4
ICD-10 Finland
Blindness, monocular
62.2
10.7
12
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
113.8
10.5
11
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
113.8
10.5
11
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
10.5
10
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
10.5
10
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
10.5
10
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
10.0
9.9
19
20
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
103.1
9.5
10
*
H27.1
ICD-10 Finland
Dislocation of lens
22.5
9.4
13
6
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
9.4
9
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
9.4
9
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
9.4
9
*
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
9.4
9
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
10.5
9.1
17
17
L04AA01
ATC
[U] ciclosporin
16.2
9.1
14
9
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
37.9
9.1
11
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.6
9.0
22
51
CFW99
NOMESCO Finland
Other operation on conjunctiva
24.9
9.0
12
5
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.0
8.8
26
70
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
28.4
8.5
11
*
S01FA02
ATC
scopolamine; ophthalmic
28.4
8.5
11
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
92.5
8.5
9
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
13.3
8.5
14
11
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
3.4
8.4
32
103
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
8.4
8
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
8.4
8
*
H16.8
ICD-10 Finland
Other keratitis
+∞
8.4
8
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
8.4
8
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
8.4
8
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
8.4
8
*
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
8.4
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
8.1
53
231
H43.1
ICD-10 Finland
Vitreous haemorrhage
7.3
7.9
18
26
S01KA02
ATC
hypromellose; ophthalmic
6.7
7.8
19
30
CD2S4
NOMESCO Finland
Photography of eye
15.5
7.8
12
8
S01BC05
ATC
ketorolac; ophthalmic
3.4
7.8
29
92
CA1ME
NOMESCO Finland
Ultrasound oculometry
18.9
7.7
11
6
H35.36
ICD-10 Finland
Macular cyst
25.7
7.6
10
*
CFB00
NOMESCO Finland
Suture of conjunctiva
82.0
7.4
8
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
82.0
7.4
8
*
37401
ICD-8 Finland
Cataract, Praesenilis
82.0
7.4
8
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
7.3
7
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
7.3
7
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
7.3
7
*
H21.0
ICD-10 Finland
Hyphaema
+∞
7.3
7
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
7.3
7
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
7.3
7
*
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
7.3
7
*
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
7.3
7
*
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
20.6
7.2
10
5
S01AA12
ATC
tobramycin; ophthalmic
20.6
7.2
10
5
Z3231
NOMESCO Finland
Registered nurse
2.0
7.1
101
603
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
7.3
7.1
16
23
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
14.2
6.9
11
8
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.9
128
835
ZXE00
NOMESCO Finland
One hour or less
1.9
6.9
129
846
Z97.0
ICD-10 Finland
Presence of artificial eye
41.0
6.8
8
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
41.0
6.8
8
*
H40.8
ICD-10 Finland
Other glaucoma
23.1
6.7
9
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
4.3
6.6
17
41
R06AX13
ATC
loratadine; oral
2.4
6.5
48
221
CJF20
NOMESCO Finland
Removal of artificial lens
71.3
6.4
7
*
CHD10
NOMESCO Finland
Trabeculectomy
71.3
6.4
7
*
D07AA02
ATC
hydrocortisone; topical
2.3
6.3
50
237
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
6.3
6
*
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
+∞
6.3
6
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
6.3
6
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
6.3
6
*
S01EX05
ATC
netarsudil; ophthalmic
+∞
6.3
6
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.6
6.3
17
32
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
11
11.30
6.85
1.4
1.5
—
—
—
0
0
8
7
11.69
4.81
1.0
1.3
—
—
—
0
0
20
82
2.54
3.46
2.1
2.9
—
—
—
0
0
267
2409
1.85
3.25
20.8
19.4
139.46
139.56
mmol/l
0.26
261
2340
73
490
1.64
3.21
1.8
1.7
1.61
1.37
mg/l
0.17
57
396
7
11
6.48
3.20
1.0
1.3
—
—
—
0
0
150
1188
1.52
3.19
4.0
4.4
0.00
0.01
estimate
0.50
23
216
257
2297
1.74
3.18
18.5
16.2
24.56
23.83
mg/l
0.13
225
1873
267
2417
1.82
3.10
20.9
19.5
3.97
4.00
mmol/l
1.11
261
2348
148
1175
1.50
3.08
3.9
4.4
0.00
0.00
estimate
0.50
31
241
6
8
7.62
3.07
1.0
1.1
—
—
—
0
0
203
1724
1.53
3.03
4.5
4.2
13.66
14.42
mm/h
0.31
175
1564
95
689
1.55
3.01
2.4
2.2
3.45
3.29
mg/l
0.26
85
585
147
1176
1.48
2.89
5.1
5.8
0.00
0.00
estimate
-0.00
23
214
22
103
2.22
2.88
2.9
4.5
1.53
1.54
%
0.01
22
95
179
1493
1.48
2.83
4.4
4.4
6.95
6.89
mmol/l
0.13
169
1400
193
1649
1.46
2.59
5.3
5.3
531.17
2862.52
e6/l
—
6
42
272
2508
1.76
2.52
27.1
23.9
245.20
242.10
e9/l
0.30
264
2444
272
2509
1.76
2.51
26.9
23.9
38.53
39.42
%
1.10
252
2338
272
2509
1.76
2.51
27.1
24.0
4.33
4.39
e12/l
1.16
263
2435
96
725
1.47
2.45
3.1
2.8
31.35
30.91
u/l
0.07
86
689
237
2122
1.52
2.41
5.1
4.8
2.11
2.02
mu/l
0.40
205
1894
211
1848
1.46
2.38
7.2
7.2
80.72
80.14
u/l
0.06
192
1722
118
934
1.43
2.33
4.1
4.7
—
—
—
0
0
9
29
3.17
2.24
1.1
1.1
—
—
—
0
0
263
2422
1.61
2.22
11.3
10.6
22.84
23.83
u/l
0.61
248
2325
9
30
3.06
2.16
1.3
1.5
—
—
—
0
0
162
1372
1.38
2.10
8.6
8.0
4.32
4.24
e9/l
0.19
149
1210
199
1744
1.40
2.10
4.3
4.0
15.27
15.07
pmol/l
0.48
174
1550
13
57
2.34
2.00
1.5
1.5
—
—
—
0
0
99
780
1.40
1.95
2.4
2.5
54.94
56.47
u/l
0.23
87
724
35
222
1.65
1.92
5.6
3.6
1.23
1.23
mmol/l
0.10
28
196
131
1087
1.36
1.87
3.1
2.5
—
—
—
0
0
112
910
1.36
1.81
3.1
3.3
2605.30
1489.12
ng/l
0.72
99
777
7
23
3.09
1.81
2.7
2.2
—
—
—
0
0
45
314
1.51
1.67
8.8
8.6
—
—
—
0
0
99
799
1.35
1.65
4.1
3.8
8.26
10.05
mg/mmol
0.25
65
507
10
44
2.31
1.57
1.4
2.5
104.40
105.45
mmol/l
—
10
44
147
1266
1.31
1.55
5.9
6.0
1.22
1.22
mmol/l
0.06
123
1069
5
15
3.37
1.53
1.2
1.1
—
—
—
0
0
5
15
3.37
1.53
1.8
2.3
—
—
—
0
0
7
27
2.63
1.52
1.0
1.6
288.29
246.68
u/l
—
7
27
7
27
2.63
1.52
2.1
7.0
—
146.80
—
0
5
85
678
1.35
1.52
4.2
4.6
0.00
0.00
estimate
-0.00
22
214
112
935
1.31
1.46
3.2
3.4
—
—
—
0
0
234
2161
1.35
1.43
16.4
15.7
74.13
73.41
ml/min/173m2
0.19
194
1793
235
2174
1.35
1.40
7.5
6.5
41.28
41.01
mmol/mol
0.16
206
1989
74
588
1.34
1.35
1.7
1.8
1247.32
1217.68
nmol/l
0.10
54
431
239
2229
1.33
1.26
4.9
4.7
4.39
4.51
mmol/l
1.02
212
2028
38
273
1.45
1.25
4.4
3.6
—
—
—
0
0
230
2139
1.30
1.20
4.3
4.2
1.26
1.27
mmol/l
0.20
198
1905
149
1316
1.26
1.19
4.9
5.7
10.78
11.46
umol/l
0.56
136
1235
46
348
1.38
1.15
1.2
1.3
18.22
45.66
iu/ml
2.72
20
108
236
2209
1.30
1.12
4.9
4.7
1.46
1.48
mmol/l
0.18
207
1987
146
1300
1.24
1.05
19.6
17.8
1.43
1.32
inr
0.47
41
377
25
172
1.49
1.03
4.6
6.0
24.98
24.66
mmol/l
0.13
25
165
35
258
1.40
1.02
2.6
3.7
1.59
2.05
mmol/l
0.24
26
207
243
2293
1.29
1.02
5.5
5.3
2.46
2.60
mmol/l
1.75
214
2063
129
1137
1.23
1.01
5.3
4.3
34.48
34.93
g/l
0.38
114
1053
35
261
1.39
0.97
2.6
3.7
5.68
5.83
kpa
0.28
35
250
122
1074
1.23
0.96
4.2
4.1
49.43
69.61
ng/l
0.28
93
817
6
27
2.25
0.94
1.0
1.1
—
—
—
0
0
124
1096
1.22
0.93
5.6
5.1
59.06
58.71
%
0.13
113
1013
24
168
1.47
0.93
1.3
1.3
—
—
—
0
0
74
621
1.25
0.90
3.5
2.7
377.31
10162.45
umol/l
3.80
59
523
237
2244
1.25
0.87
5.5
4.9
6.17
6.08
mmol/l
0.50
210
2000
125
1113
1.21
0.86
6.2
5.4
25.79
26.27
%
0.19
115
1028
124
1107
1.20
0.83
2.2
2.1
92.86
93.23
pmol/l
0.03
55
563
6
32
1.89
0.82
1.3
1.5
—
—
—
0
0
92
802
1.21
0.78
1.8
2.1
165.50
203.09
u/l
0.36
86
754
0
27
0.00
0.78
0.0
1.0
—
2.71
—
0
12
85
736
1.21
0.77
5.5
5.2
2.54
2.90
ug/l
0.22
71
648
8
133
0.59
0.75
8.4
6.4
22.32
24.81
mmol/l
—
8
127
5
24
2.10
0.75
1.0
1.3
—
—
—
0
0
129
1166
1.18
0.73
5.2
5.1
1.21
1.22
mmol/l
0.41
118
1048
5
25
2.02
0.73
1.0
1.6
—
20.33
—
0
6
42
338
1.28
0.73
3.5
5.2
104.48
103.69
mmol/l
0.39
42
338
7
40
1.77
0.71
1.0
1.1
—
—
—
0
0
68
585
1.21
0.66
4.5
4.7
20.26
21.52
%
0.34
31
290
62
531
1.21
0.63
4.5
4.0
114.74
183.44
ng/l
0.32
47
459
5
30
1.68
0.61
1.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
3.9
—
—
—
0
0
52
440
1.22
0.60
2.4
2.4
12.95
12.27
umol/l
0.25
45
399
81
717
1.18
0.58
3.1
3.3
0.43
0.48
e6/l
0.11
66
555
37
303
1.25
0.58
2.0
1.7
—
—
—
0
0
8
54
1.49
0.57
1.4
1.4
—
—
—
0
0
8
55
1.47
0.56
1.4
1.5
—
—
—
0
0
8
125
0.63
0.55
1.8
1.6
—
—
—
0
0
70
615
1.18
0.55
2.0
1.8
103509220.02
440.53
pmol/l
0.49
57
493
27
214
1.29
0.54
2.8
3.8
71.68
84.50
ng/l
0.61
19
188
9
61
1.49
0.54
2.9
2.7
3.09
3.35
g/l
—
9
56
45
381
1.21
0.53
2.4
2.5
22.30
21.34
%
0.16
36
321
9
63
1.44
0.53
1.4
1.3
—
—
—
0
0
18
234
0.75
0.50
4.8
4.7
1.41
1.53
mmol/l
0.27
18
226
47
402
1.20
0.50
2.4
2.4
2.31
2.31
g/l
0.00
42
360
28
227
1.26
0.48
2.3
2.7
4.89
4.22
kpa
0.63
28
216
5
82
0.60
0.46
4.4
2.6
25.68
24.81
mmol/l
—
5
82
24
193
1.26
0.45
2.5
3.0
74.91
59.15
ml/min/173m2
0.97
11
86
108
997
1.13
0.43
2.5
2.3
80.19
77.43
nmol/l
0.48
90
869
6
92
0.65
0.43
1.0
1.9
—
—
—
0
0
8
58
1.39
0.42
1.4
1.5
—
—
—
0
0
37
316
1.19
0.41
1.4
1.3
7.28
14.63
u/ml
0.43
17
114
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
7
102
0.68
0.40
1.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
10
137
0.72
0.40
2.1
2.6
—
14.10
—
0
7
8
61
1.32
0.40
1.5
1.5
—
—
—
0
0
5
35
1.44
0.39
1.6
1.4
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.4
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
31
264
1.19
0.36
2.0
2.6
5.48
6.38
ug/l
0.20
26
234
6
41
1.47
0.36
1.3
1.6
—
—
—
0
0
6
44
1.37
0.34
1.3
1.3
—
—
—
0
0
34
294
1.18
0.34
3.9
4.0
224.18
243.67
u/l
0.82
34
272
6
45
1.34
0.34
5.0
3.6
64.17
61.56
%
—
6
45
111
1177
0.91
0.31
2.7
2.5
—
—
—
0
0
7
99
0.70
0.31
1.0
1.3
—
—
—
0
0
75
694
1.11
0.29
1.7
1.6
20.28
20.48
nmol/l
0.03
64
573
147
1405
1.09
0.29
2.9
3.1
59.99
52.24
u/l
0.43
130
1290
9
120
0.74
0.28
1.2
1.4
—
40.36
—
0
11
104
981
1.09
0.27
3.3
2.8
132.23
128.46
ug/l
0.07
96
882
17
141
1.22
0.26
2.2
2.6
0.91
1.22
%
1.16
17
141
8
67
1.20
0.26
1.9
1.4
—
—
—
0
0
34
302
1.14
0.26
2.0
1.7
—
—
—
0
0
19
161
1.19
0.24
4.8
3.9
2.14
2.19
mmol/l
0.01
14
117
96
908
1.08
0.24
3.7
3.2
2.32
2.35
mmol/l
1.25
81
777
34
304
1.13
0.24
4.5
4.9
32.94
32.59
%
0.06
17
199
5
42
1.19
0.21
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
172.63
—
0
11
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
47
433
1.10
0.21
3.2
3.0
0.53
0.86
ug/l
3.32
32
284
10
80
1.26
0.20
1.0
2.4
0.00
0.00
g/l
—
10
73
12
99
1.22
0.20
1.1
1.0
—
—
—
0
0
11
90
1.23
0.19
1.0
2.6
0.00
0.76
g/l
1.83
11
78
8
72
1.11
0.16
1.0
2.6
0.00
0.00
g/l
—
8
67
13
111
1.18
0.16
2.9
2.3
—
—
—
0
0
61
578
1.07
0.15
2.2
2.2
—
—
—
0
0
22
198
1.12
0.15
1.5
1.6
—
—
—
0
0
33
305
1.09
0.14
4.7
5.4
1.36
1.64
mmol/l
0.12
23
245
47
443
1.07
0.13
2.1
1.8
—
—
—
0
0
9
109
0.82
0.13
2.4
1.7
—
—
—
0
0
49
466
1.06
0.11
1.3
1.2
0.64
1.49
u/ml
1.11
16
126
25
270
0.92
0.11
1.6
1.4
—
—
—
0
0
10
115
0.87
0.11
2.3
1.9
—
—
—
0
0
26
241
1.09
0.10
5.7
5.9
115.85
121.44
g/l
0.78
26
235
56
584
0.95
0.10
1.9
1.6
1.35
1.32
mmol/l
0.12
47
478
5
44
1.14
0.10
1.6
1.3
—
—
—
0
0
10
114
0.87
0.09
1.9
3.4
7.70
1593.71
u/ml
—
10
100
32
302
1.07
0.09
4.3
5.4
5.10
5.12
kpa
0.03
32
287
32
302
1.07
0.09
4.3
5.4
11.04
11.40
kpa
0.17
32
289
8
74
1.08
0.07
1.0
2.5
0.00
0.00
g/l
—
8
67
54
558
0.96
0.07
3.3
3.0
2.45
2.46
mmol/l
0.21
45
485
12
110
1.09
0.05
3.1
2.3
3.48
3.52
g/l
0.04
12
97
16
170
0.94
0.04
1.9
1.6
—
—
—
0
0
41
399
1.03
0.03
2.8
3.2
2.56
3.22
e6/l
0.25
27
231
43
421
1.02
0.02
2.7
3.0
0.72
1.30
e6/l
1.53
29
250
10
94
1.07
0.01
1.2
1.2
—
—
—
0
0
11
112
0.98
0.00
1.4
2.5
30.18
31.54
u/ml
0.03
11
107
13
126
1.03
0.00
2.5
4.2
23.32
24.09
mmol/l
0.58
13
120
27
266
1.02
0.00
1.8
2.4
10.09
8.54
umol/l
0.16
20
229
28
284
0.98
0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
95.00
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
14.34
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
75
0.93
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.18
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.5
—
—
—
0
0
7
75
0.93
-0.00
1.0
1.2
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.3
—
—
—
0
0
5
50
1.00
-0.00
2.2
1.5
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_BULLKERATOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.232 [1.06, 1.43] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 1262 females with H7_BULLKERATOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.031 [0.86, 1.23] | 0.739 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 869 males with H7_BULLKERATOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_BULLKERATOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.201% |
| 5 | 0.61% | 1.199% |
| 10 | 1.702% | 3.042% |
| 15 | 3.265% | 5.816% |
| 20 | 6.012% | 9.836% |
Relationships between endpoints
↥Index endpoint: H7_BULLKERATOPATHY – Bullous keratopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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