No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
583 |
4. Check minimum number of eventsNone |
583 |
5. Include endpointsNone |
583 |
6. Filter based on genotype QC (FinnGen only) |
567 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Degeneratio corneae
Similar endpoints
↥List of similar endpoints to
Corneal degeneration
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3016 | 1902 | 1102 |
| Only index persons | 2762 | 1757 | 1005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.03 |
| Only index persons | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.63 | 67.79 | 62.16 |
| Only index persons | 64.93 | 66.76 | 61.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 567 | 377 | 190 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.09 |
| Median age at first event (years) | 65.77 | 64.61 | 68.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 583
- Matched controls
- 5830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.4
ICD-10 Finland
Corneal degeneration
+∞
307.7
564
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
2062.3
164.8
152
*
H16.0
ICD-10 Finland
Corneal ulcer
31.6
145.9
98
37
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.1
115.8
195
339
CG2T4
NOMESCO Finland
Topography assessment of cornea
206.3
115.1
116
7
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
8.6
112.4
474
1957
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.4
94.3
205
454
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
275.9
93.5
93
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
84.4
207
507
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.9
68.8
149
321
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
65.9
62
*
CG2S4
NOMESCO Finland
Photography of cornea
182.5
63.4
65
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
579.2
54.5
53
*
WX140
NOMESCO Finland
Parabulbar anesthesy
7.3
54.5
87
137
ZXA10
NOMESCO Finland
Bilateral
3.9
51.4
206
709
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
50.5
129
316
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
185.9
49.7
51
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.4
46.4
309
1454
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
166.1
44.5
46
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
41.8
294
1406
H16.9
ICD-10 Finland
Keratitis, unspecified
118.8
41.3
44
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
41.1
39
*
S01ED01
ATC
timolol; ophthalmic
8.6
41.1
55
70
TCG10
NOMESCO Finland
Removal of sutures from cornea
425.6
40.6
40
*
CGE10
NOMESCO Finland
Keratectomy
+∞
40.1
38
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.6
39.1
105
265
H25.1
ICD-10 Finland
Senile nuclear cataract
3.1
38.6
260
1201
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.1
34.5
80
178
H26.4
ICD-10 Finland
After-cataract
3.9
34.1
115
342
WX002
NOMESCO Finland
Sedation and analgesia
3.1
33.4
188
773
H04.10
ICD-10 Finland
Dry eye syndrome
3.8
33.0
120
376
H18.6
ICD-10 Finland
Keratoconus
+∞
30.5
29
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
28.4
27
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
28.4
27
*
S01ED51
ATC
timolol, combinations; ophthalmic
4.1
27.4
83
227
S01EA05
ATC
brimonidine; ophthalmic
9.0
26.9
34
40
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
4.5
26.3
69
169
S01BC03
ATC
diclofenac; ophthalmic
9.6
25.8
31
34
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
25.2
24
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
25.2
24
*
S01BA01
ATC
dexamethasone; ophthalmic
6.1
25.0
45
79
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
90.6
23.9
26
*
S01EC01
ATC
acetazolamide; systemic
8.2
23.6
32
41
Z3231
NOMESCO Finland
Registered nurse
2.5
23.4
207
1047
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
23.3
154
675
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
23.1
22
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
23.1
22
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.5
22.6
85
269
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
22.0
21
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
22.0
21
*
ZXA05
NOMESCO Finland
Left side
2.4
21.1
199
1028
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
19.9
19
*
XCK00
NOMESCO Finland
Perimetry
3.8
19.1
62
177
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
18.8
18
*
S01BA04
ATC
prednisolone; ophthalmic
7.3
18.8
28
40
CD2S4
NOMESCO Finland
Photography of eye
29.8
17.5
23
8
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
14.5
17.5
29
21
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
16.7
16
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
20.8
16.5
24
12
S01GX01
ATC
cromoglicic acid; ophthalmic
2.4
16.4
144
711
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
15.7
15
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
164.2
15.6
16
*
S01EE01
ATC
latanoprost; ophthalmic
3.4
14.8
56
177
H40.0
ICD-10 Finland
Glaucoma suspect
3.0
14.7
70
254
S01EE04
ATC
travoprost; ophthalmic
6.5
14.7
24
38
H18.2
ICD-10 Finland
Other corneal oedema
+∞
14.6
14
*
H18.7
ICD-10 Finland
Other corneal deformities
+∞
14.6
14
*
S01AD03
ATC
aciclovir; ophthalmic
4.6
14.5
35
80
H52.2
ICD-10 Finland
Astigmatism
6.4
14.3
24
39
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
22.9
14.3
20
9
H57.1
ICD-10 Finland
Ocular pain
4.4
13.6
35
84
Z2221
NOMESCO Finland
Medical doctor
2.0
13.3
184
1076
H16.2
ICD-10 Finland
Keratoconjunctivitis
71.5
12.6
14
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
12.5
271
1836
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
12.5
12
*
H3603, E103,
ICD-10 Finland
132.8
12.5
13
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.6
12.4
42
123
S01BA07
ATC
fluorometholone; ophthalmic
9.3
12.4
25
28
S01EA03
ATC
apraclonidine; ophthalmic
16.3
12.2
19
12
H26.2
ICD-10 Finland
Complicated cataract
11.4
12.1
22
20
ZXA00
NOMESCO Finland
Right side
1.9
12.1
192
1173
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
5.9
11.6
21
37
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
11.5
11
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
11.5
11
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
122.3
11.5
12
*
114
Kela drug reimbursment
Glaucoma
2.6
11.3
69
285
H43.1
ICD-10 Finland
Vitreous haemorrhage
5.4
11.1
22
42
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
14.2
11.0
18
13
S01FA01
ATC
atropine; ophthalmic
28.6
10.8
14
5
S01FA02
ATC
scopolamine; ophthalmic
61.1
10.7
12
*
S01AA01
ATC
chloramphenicol; ophthalmic
3.4
10.5
39
122
H26.02
ICD-10 Finland
Presenil cataract
4.3
10.5
27
65
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
10.4
10
*
S01XA18
ATC
ciclosporin; ophthalmic
17.1
9.9
15
9
H11.0
ICD-10 Finland
Pterygium
12.5
9.9
17
14
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
9.9
239
1643
S01EC04
ATC
brinzolamide; ophthalmic
3.3
9.6
36
113
ZXE00
NOMESCO Finland
One hour or less
1.8
9.5
236
1629
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
9.4
9
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
9.4
9
*
H27.0
ICD-10 Finland
Aphakia
19.0
9.0
13
7
H54.4
ICD-10 Finland
Blindness, monocular
24.4
8.9
12
5
L04AA01
ATC
[U] ciclosporin
7.8
8.7
19
25
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.8
8.5
26
71
H15.1
ICD-10 Finland
Episcleritis
28.0
8.5
11
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.2
8.4
33
107
3604
FHL
Penetration of the cornea
+∞
8.4
8
*
ZXD20
NOMESCO Finland
Day surgery
2.1
8.3
89
467
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.6
8.1
46
183
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
33.9
8.1
10
*
L28
ICPC
Limited function/disability (L)
1.9
8.0
115
669
S01EE05
ATC
tafluprost; ophthalmic
3.1
7.9
33
111
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.7
7.9
42
162
S01KA02
ATC
hypromellose; ophthalmic
4.3
7.8
20
48
H35.36
ICD-10 Finland
Macular cyst
18.6
7.6
11
6
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.2
7.6
20
49
J01FA10
ATC
azithromycin; systemic
1.6
7.5
323
2527
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.0
7.5
21
54
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
7.3
7
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
7.3
7
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
7.3
7
*
H16.8
ICD-10 Finland
Other keratitis
+∞
7.3
7
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
30.4
7.2
9
*
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
8.1
7.1
15
19
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.0
7.1
30
102
S01EC03
ATC
dorzolamide; ophthalmic
7.1
7.0
16
23
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
6.9
79
424
A98
ICPC
Health maint/preventive medicine
3.5
6.8
566
5276
S01AA12
ATC
tobramycin; ophthalmic
40.5
6.8
8
*
CHD99
NOMESCO Finland
Other filtering operation
16.9
6.8
10
6
F29
ICPC
Eye symptom/complaint other
2.1
6.6
63
316
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
8.8
6.6
13
15
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
70.6
6.4
7
*
S01AX11
ATC
[U] ofloxacin
3.0
6.3
27
92
F01
ICPC
Eye pain
3.5
6.3
21
61
H20
ICD-10 Finland
Iridocyclitis
18.2
6.3
9
5
S01EA02
ATC
dipivefrine; ophthalmic
18.2
6.3
9
5
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
6.3
6
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
6.3
6
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
6.3
6
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
6.3
6
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
6.3
6
*
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
6.3
6
*
CFD10
NOMESCO Finland
Repair of conjunctiva
27.0
6.2
8
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
27.0
6.2
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.2
249
1888
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.7
6.2
34
133
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.1
214
1573
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
317
2291
1.84
11.66
6.9
5.3
1.22
1.22
mmol/l
0.54
290
2068
332
2482
1.78
10.46
7.9
6.3
1.22
1.22
mmol/l
1.27
281
2118
288
2072
1.77
10.30
2.4
2.3
80.38
78.01
nmol/l
0.82
246
1836
274
2044
1.64
7.86
2.1
2.0
102.80
97.76
pmol/l
0.73
129
1036
278
2128
1.59
6.87
4.3
4.3
35.80
35.40
g/l
0.61
251
1990
539
4931
2.23
6.37
5.2
5.1
2.67
2.76
mmol/l
1.31
473
4507
295
2320
1.55
6.28
6.9
6.0
27.74
27.69
%
0.02
277
2173
443
3834
1.65
6.12
7.5
7.5
76.18
78.50
u/l
0.58
419
3595
290
2287
1.53
6.00
6.7
5.7
56.84
57.40
%
0.33
270
2140
174
1225
1.60
5.96
4.2
3.6
91.33
92.13
%
0.16
169
1197
530
4842
2.04
5.90
4.6
4.6
4.63
4.70
mmol/l
0.74
468
4447
122
787
1.70
5.89
3.3
2.8
1.62
2.92
e6/l
1.29
72
422
426
3666
1.60
5.88
4.9
4.1
14.06
12.62
mm/h
1.17
390
3373
138
928
1.64
5.66
3.4
3.8
264.39
230.36
ng/l
0.14
115
743
234
1785
1.52
5.53
3.8
3.1
—
—
—
0
0
342
2824
1.51
5.51
9.0
9.2
4.06
4.02
e9/l
0.14
298
2472
526
4815
1.95
5.48
4.6
4.5
1.52
1.51
mmol/l
0.28
464
4396
70
391
1.90
5.46
4.7
3.2
90.83
78.47
ng/l
0.73
61
340
126
847
1.62
5.14
3.2
2.6
0.63
1.21
e6/l
2.59
76
479
200
1494
1.52
5.13
3.5
3.1
31.56
90.76
e6/l
0.70
160
1139
228
1752
1.49
5.10
2.9
3.5
2.37
2.36
mmol/l
0.94
194
1528
12
20
6.10
4.93
1.4
1.3
—
—
—
0
0
185
1373
1.51
4.85
3.5
3.0
0.28
0.40
e6/l
0.67
143
1023
551
5170
2.20
4.68
12.1
10.7
24.55
25.30
u/l
0.52
530
4973
40
194
2.14
4.62
1.7
2.2
44.29
39.03
u/l
0.62
34
170
94
610
1.64
4.38
8.0
4.6
1.02
1.02
mmol/l
0.08
88
547
523
4841
1.78
4.37
16.9
14.0
21.62
23.12
mg/l
0.56
421
3796
295
2434
1.43
4.34
3.7
3.7
0.00
0.01
estimate
0.80
50
428
15
38
4.02
4.32
1.7
1.4
—
—
—
0
0
292
2408
1.43
4.29
5.1
5.0
0.00
0.00
estimate
0.50
47
442
496
4540
1.62
4.17
5.4
4.9
1.85
2.21
mu/l
0.71
452
4100
290
2398
1.42
4.15
3.7
3.7
0.00
0.00
estimate
0.50
52
474
539
5058
1.87
3.96
19.6
16.3
3.95
3.97
mmol/l
0.89
520
4915
504
4646
1.63
3.94
4.1
4.1
1.27
1.28
mmol/l
0.26
441
4206
562
5354
2.38
3.92
25.4
21.1
39.72
39.89
%
0.30
526
5010
85
553
1.63
3.92
2.3
2.5
4.88
8.11
umol/l
3.42
72
484
562
5357
2.36
3.86
25.1
21.1
4.40
4.45
e12/l
1.70
546
5203
537
5042
1.82
3.82
19.3
16.2
139.61
139.70
mmol/l
0.32
518
4906
562
5360
2.35
3.80
25.3
21.2
132.34
134.24
g/l
2.51
554
5273
250
2040
1.39
3.75
3.4
2.7
120.25
128.49
ug/l
0.21
231
1859
561
5354
2.27
3.66
25.2
21.1
254.40
250.15
e9/l
0.85
547
5217
158
1201
1.43
3.51
1.6
1.5
21.62
21.07
nmol/l
0.14
123
1002
499
4644
1.52
3.13
16.5
13.2
77.70
78.84
ml/min/173m2
0.52
408
3823
127
954
1.42
2.98
1.7
1.7
1173.32
1228.57
nmol/l
0.26
93
700
22
102
2.20
2.90
1.4
1.3
—
—
—
0
0
319
2778
1.33
2.88
2.7
2.8
—
—
—
0
0
191
1550
1.35
2.78
3.8
3.1
7.07
7.03
mmol/l
0.04
160
1282
67
448
1.56
2.78
2.8
2.3
33.45
32.74
u/l
0.08
58
375
153
1201
1.37
2.76
2.4
2.1
2.73
3.19
mg/l
1.63
132
1019
79
551
1.50
2.71
1.5
1.8
—
—
—
0
0
490
4579
1.44
2.66
6.5
5.9
40.55
39.91
mmol/mol
0.70
447
4222
509
4794
1.49
2.61
5.0
4.7
5.96
5.95
mmol/l
0.09
451
4327
133
1034
1.37
2.53
2.5
2.5
5.28
6.11
e6/l
0.30
116
930
9
26
3.50
2.49
1.3
3.2
63.89
131.00
nmol/l
—
9
26
29
160
1.86
2.44
1.2
1.8
36.99
37.82
g/l
0.21
23
140
124
959
1.37
2.43
2.7
3.0
2.46
2.46
mmol/l
0.08
107
852
95
704
1.42
2.39
3.6
2.1
2.26
2.36
g/l
0.93
87
654
326
2896
1.29
2.33
4.9
4.4
6.69
6.72
mmol/l
0.07
308
2727
42
263
1.64
2.31
1.4
1.2
377.67
181.74
u/ml
0.61
37
241
189
1570
1.30
2.27
4.2
3.7
6.46
7.57
mg/mmol
0.28
113
961
101
764
1.39
2.26
3.6
2.1
13.24
12.94
umol/l
0.16
91
708
29
165
1.80
2.23
1.1
2.2
0.20
0.88
g/l
1.23
23
144
76
549
1.44
2.21
1.5
1.8
—
—
—
0
0
298
2640
1.26
2.10
4.6
6.2
10.24
10.90
umol/l
0.90
276
2502
42
271
1.59
2.07
2.8
3.4
4.26
4.50
pmol/l
0.94
36
234
20
104
1.96
2.02
1.3
1.1
—
—
—
0
0
111
869
1.34
2.01
1.3
1.3
23.07
36.61
iu/ml
0.62
42
273
30
181
1.69
1.92
1.2
2.0
3.25
2.98
g/l
0.58
24
161
145
1187
1.29
1.91
2.5
2.3
—
—
—
0
0
101
789
1.34
1.86
2.5
3.2
0.82
0.82
mmol/l
0.11
96
737
100
781
1.34
1.84
1.6
1.9
—
—
—
0
0
161
1342
1.28
1.84
1.6
1.7
1.22
1.36
mmol/l
1.97
137
1127
30
185
1.66
1.79
1.2
2.0
10.80
10.50
g/l
0.19
24
164
409
3800
1.26
1.74
4.4
4.0
15.18
14.84
pmol/l
1.83
372
3424
8
30
2.69
1.73
1.5
1.5
7.23
5.38
u/l
—
8
25
23
133
1.76
1.72
1.3
1.6
—
—
—
0
0
22
126
1.78
1.70
1.5
2.1
12.31
12.45
mg/l
0.02
22
113
31
196
1.61
1.69
1.2
2.0
7.57
7.48
g/l
0.09
25
176
31
196
1.61
1.69
1.2
2.0
—
—
—
0
0
87
675
1.34
1.68
4.0
2.1
23.08
21.84
%
0.43
73
570
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
14
3.59
1.62
4.0
1.9
139.60
122.86
%
—
5
14
7
26
2.71
1.58
1.3
1.2
—
84.29
—
0
7
181
1566
1.23
1.46
2.7
3.1
33.12
31.26
u/l
0.14
172
1497
30
196
1.56
1.46
1.2
2.0
4.02
3.56
g/l
2.33
25
176
22
133
1.68
1.44
3.4
2.8
4.00
3.62
g/l
0.52
22
128
23
141
1.66
1.43
2.1
2.3
96.87
91.00
%
0.88
23
135
262
2357
1.20
1.41
14.8
13.4
1.28
1.24
inr
0.27
64
680
11
53
2.10
1.39
1.1
1.2
56.78
51.80
u/l
0.23
11
47
176
1528
1.22
1.37
2.1
2.1
120.54
236.27
u/l
1.67
167
1442
6
23
2.62
1.37
1.5
1.3
—
—
—
0
0
25
161
1.58
1.31
2.0
2.9
—
—
—
0
0
18
106
1.72
1.31
1.5
1.6
—
—
—
0
0
13
69
1.90
1.29
1.3
1.7
—
—
—
0
0
23
146
1.60
1.28
1.4
1.6
—
111.43
—
0
7
41
296
1.41
1.26
1.5
1.7
—
—
—
0
0
23
147
1.59
1.25
1.3
1.5
37.30
28.78
iu/l
0.47
17
122
15
85
1.78
1.24
1.3
1.2
—
—
—
0
0
16
93
1.74
1.22
1.6
1.5
22.36
10.91
u/l
—
10
74
6
26
2.32
1.19
1.5
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
141
1.58
1.19
2.3
2.6
0.34
0.35
u/ml
—
9
83
0
33
0.00
1.16
0.0
1.4
—
—
—
0
0
0
33
0.00
1.16
0.0
1.4
—
—
—
0
0
91
751
1.25
1.14
3.1
3.1
0.69
0.77
ug/l
0.69
70
491
31
218
1.45
1.11
7.7
3.4
24.42
24.00
mmol/l
0.29
31
212
5
21
2.39
1.09
1.8
1.9
108.40
105.33
%
—
5
21
8
41
1.96
1.09
2.0
2.2
—
—
—
0
0
15
89
1.70
1.08
1.3
1.3
—
—
—
0
0
15
89
1.70
1.08
1.3
1.3
—
—
—
0
0
18
114
1.60
1.03
1.9
1.2
—
—
—
0
0
21
139
1.53
1.01
1.1
1.4
288.92
281.96
ug/g
—
10
80
7
35
2.01
1.00
1.3
1.4
0.89
1.03
g/l
—
7
35
7
35
2.01
1.00
1.0
1.5
—
22.14
—
0
7
5
23
2.18
0.98
1.2
3.3
716.40
1019.13
u/ml
—
5
23
144
1270
1.18
0.93
2.6
2.7
2752.87
7109.18
umol/l
0.90
126
1092
12
70
1.73
0.93
1.0
1.1
3.67
7.33
u/ml
—
6
27
87
735
1.22
0.90
1.6
1.4
—
—
—
0
0
50
397
1.28
0.88
2.7
2.6
64.06
64.23
ml/min/173m2
0.01
17
166
10
56
1.80
0.88
1.1
1.1
121.60
119.78
%
—
10
51
11
64
1.73
0.86
1.0
1.1
—
—
—
0
0
144
1283
1.16
0.82
5.0
5.1
2.06
2.51
ug/l
0.71
129
1146
119
1045
1.17
0.82
1.4
1.3
0.96
1.83
u/ml
0.93
29
271
56
458
1.25
0.79
2.3
2.0
318.95
380.48
nmol/l
1.64
44
416
7
124
0.56
0.78
2.3
2.4
25.36
25.39
mmol/l
—
7
124
6
34
1.77
0.76
1.0
1.3
5.20
6.82
u/l
—
6
26
14
91
1.55
0.75
2.5
3.1
53.86
60.59
%
0.72
14
91
44
352
1.27
0.75
2.0
1.5
—
—
—
0
0
116
1024
1.17
0.75
3.8
4.5
22.29
20.81
%
0.55
57
491
121
1074
1.16
0.73
1.7
1.8
1.98
1.23
mg/l
0.75
96
823
98
857
1.17
0.72
1.3
1.2
28.31
13.43
u/ml
0.52
23
316
7
40
1.76
0.71
1.3
1.6
—
—
—
0
0
146
1317
1.14
0.71
4.1
4.0
0.00
0.01
estimate
0.88
47
435
9
143
0.62
0.70
1.1
1.9
—
—
—
0
0
10
61
1.65
0.69
1.1
1.0
—
—
—
0
0
248
2318
1.12
0.68
2.6
2.5
—
—
—
0
0
7
43
1.64
0.67
1.0
1.2
—
—
—
0
0
76
656
1.18
0.66
5.1
4.5
33.57
32.35
%
0.38
44
421
163
1491
1.13
0.64
2.9
3.1
1218.36
1113.41
ng/l
0.16
137
1269
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
5
29
1.73
0.64
1.2
1.3
1.63
1.62
g/l
—
5
29
13
87
1.51
0.63
2.3
2.7
4.26
4.57
e9/l
0.17
13
87
22
166
1.34
0.59
1.3
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
2.4
—
45.56
—
0
18
74
646
1.17
0.57
6.4
7.2
—
—
—
0
0
6
37
1.63
0.55
1.0
1.0
870.50
629.77
ng/l
—
6
22
6
37
1.63
0.55
1.0
1.0
326.33
268.43
ng/l
—
6
21
6
37
1.63
0.55
1.0
1.0
48.17
37.20
ng/l
—
6
21
18
133
1.36
0.55
1.4
1.5
—
—
—
0
0
86
762
1.15
0.55
1.4
1.4
—
—
—
0
0
49
415
1.20
0.54
1.4
2.8
65.17
66.82
g/l
0.60
41
374
34
278
1.24
0.52
2.4
2.2
10.91
12.62
nmol/l
0.46
27
249
170
1579
1.11
0.51
2.6
2.4
59.86
57.44
u/l
0.14
151
1465
19
144
1.33
0.51
1.1
1.2
—
—
—
0
0
19
145
1.32
0.49
1.1
1.2
—
—
—
0
0
328
3150
1.09
0.49
3.0
3.0
41.90
50.39
u/l
1.64
306
2921
19
146
1.31
0.47
1.9
1.5
0.06
0.11
iu/ml
—
5
27
117
1073
1.11
0.45
1.8
1.7
432.85
21445395.11
pmol/l
1.06
97
872
48
415
1.17
0.44
1.5
2.2
9.25
7.17
ug/l
0.23
39
362
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.2
1.3
—
—
—
0
0
5
31
1.62
0.43
1.2
1.3
—
—
—
0
0
8
56
1.43
0.42
1.3
1.6
—
—
—
0
0
19
149
1.28
0.42
1.2
1.2
—
18.20
—
0
8
5
33
1.52
0.41
1.2
1.5
—
62.00
—
0
5
5
33
1.52
0.41
1.0
2.0
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.5
—
320.00
—
0
5
0
19
0.00
0.39
0.0
1.5
—
7.88
—
0
19
15
117
1.29
0.35
1.9
1.7
5.23
6.68
iu/l
—
7
34
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
34
293
1.17
0.34
1.5
1.4
—
—
—
0
0
16
127
1.27
0.34
1.1
1.4
642.63
475.35
mg/l
0.52
16
118
18
146
1.24
0.32
1.1
1.2
—
—
—
0
0
49
439
1.13
0.30
5.6
3.3
1.66
1.88
mmol/l
0.15
40
356
7
54
1.30
0.30
1.0
1.1
—
—
—
0
0
8
108
0.74
0.29
1.8
2.4
8.10
8.09
kpa
—
8
108
11
140
0.78
0.28
1.3
1.2
—
—
—
0
0
51
563
0.90
0.28
4.1
4.1
3.79
32.11
ug/l
1.26
35
473
10
76
1.32
0.28
1.3
1.5
—
—
—
0
0
14
114
1.23
0.25
1.1
1.4
3.74
3.85
mmol/l
0.18
14
105
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
14
116
1.21
0.22
1.1
1.2
—
11.90
—
0
8
17
144
1.19
0.22
2.2
1.6
—
—
—
0
0
5
41
1.22
0.22
1.4
1.1
—
—
—
0
0
26
229
1.14
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
26
230
1.14
0.21
3.0
2.4
1.27
1.17
%
0.32
26
230
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
3.2
3.9
—
—
—
0
0
15
127
1.19
0.19
2.3
1.7
—
—
—
0
0
12
99
1.22
0.19
1.7
2.0
117.17
129.87
g/l
—
6
71
49
453
1.09
0.19
9.3
7.5
118.55
119.67
g/l
0.16
49
441
30
332
0.90
0.19
1.8
1.8
—
—
—
0
0
25
223
1.13
0.18
3.0
2.4
0.55
0.65
%
1.15
25
223
48
516
0.92
0.17
3.7
3.1
—
—
—
0
0
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
7
61
1.15
0.17
6.6
5.9
12.31
11.53
mg/l
—
7
54
8
70
1.14
0.16
1.3
1.6
—
—
—
0
0
44
409
1.08
0.16
5.0
3.7
1.22
1.23
mmol/l
0.25
38
359
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
8
73
1.10
0.15
1.5
1.5
—
—
—
0
0
18
160
1.13
0.14
1.4
1.4
—
—
—
0
0
42
393
1.07
0.13
1.9
1.7
—
—
—
0
0
25
228
1.10
0.13
1.2
1.3
—
—
—
0
0
30
324
0.92
0.13
1.0
1.2
51.11
145.20
iu/ml
—
8
136
14
123
1.14
0.12
1.3
1.7
—
—
—
0
0
13
147
0.88
0.11
1.5
1.4
—
—
—
0
0
14
124
1.13
0.11
1.3
1.4
—
—
—
0
0
17
153
1.11
0.11
2.7
1.8
—
—
—
0
0
20
183
1.10
0.10
1.9
1.7
—
—
—
0
0
105
1081
0.97
0.10
4.5
4.1
1.02
1.02
kg/l
0.26
11
152
194
1904
1.03
0.10
3.5
3.6
55.41
51.76
ng/l
0.05
137
1377
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
10
87
1.15
0.09
1.4
1.8
—
—
—
0
0
5
63
0.79
0.08
1.2
1.6
—
—
—
0
0
57
549
1.04
0.08
8.3
6.8
1.53
1.21
mmol/l
0.26
51
448
7
64
1.09
0.08
1.0
1.0
—
15.23
—
0
13
8
78
1.03
0.07
1.3
1.3
—
—
—
0
0
7
84
0.83
0.07
1.3
1.8
—
—
—
0
0
7
84
0.83
0.07
1.1
1.2
—
—
—
0
0
7
84
0.83
0.07
1.3
1.7
—
—
—
0
0
13
118
1.10
0.07
1.2
1.2
—
—
—
0
0
50
482
1.04
0.07
1.8
1.7
1.54
1.52
%
0.04
45
411
9
87
1.04
0.07
1.1
1.6
—
—
—
0
0
9
105
0.85
0.06
1.4
1.5
—
—
—
0
0
14
129
1.09
0.05
2.7
2.5
14.90
81.75
ug/min
—
5
83
10
90
1.11
0.05
3.2
2.4
15.78
16.12
%
—
5
46
20
192
1.04
0.02
2.2
1.9
—
—
—
0
0
189
1878
1.01
0.02
4.0
3.9
—
—
—
0
0
30
304
0.99
0.00
3.2
3.5
1.57
1.94
mmol/l
0.25
21
237
12
118
1.02
0.00
1.3
1.7
—
—
—
0
0
12
118
1.02
0.00
1.4
1.3
—
—
—
0
0
12
122
0.98
0.00
1.0
1.6
—
—
—
0
0
30
299
1.00
0.00
1.6
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
7.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
7
69
1.01
0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.4
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.4
2.0
—
—
—
0
0
7
75
0.93
-0.00
1.4
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
74
0.95
-0.00
3.9
4.6
365.43
370.58
umol/l
—
7
67
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
8
79
1.01
-0.00
1.1
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.4
—
—
—
0
0
5
51
0.98
-0.00
1.4
2.1
—
—
—
0
0
9
96
0.94
-0.00
2.0
1.8
35.33
44.12
nmol/l
—
9
91
5
59
0.85
-0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.1
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALDYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.201 [1.0, 1.44] | 0.048 |
| Birth year | 0.994 [0.99, 1.0] | 0.189 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 1316 females with H7_CORNEALDYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.171 [0.91, 1.51] | 0.228 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 781 males with H7_CORNEALDYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALDYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.305% |
| 5 | 0.783% | 1.513% |
| 10 | 1.754% | 3.959% |
| 15 | 3.484% | 7.537% |
| 20 | 5.907% | 13.452% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALDYSTROPHY – Corneal degeneration
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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