No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
505 |
4. Check minimum number of eventsNone |
505 |
5. Include endpointsNone |
505 |
6. Filter based on genotype QC (FinnGen only) |
505 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Degeneratio corneae
Similar endpoints
↥List of similar endpoints to
Corneal degeneration
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3016 | 1902 | 1102 |
| Only index persons | 2762 | 1757 | 1005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.03 |
| Only index persons | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.63 | 67.79 | 62.16 |
| Only index persons | 64.93 | 66.76 | 61.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 505 | 333 | 172 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 64.85 | 63.76 | 66.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 432
- Matched controls
- 4322
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.4
ICD-10 Finland
Corneal degeneration
+∞
323.0
414
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
113.7
104
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
303.3
96.9
95
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
8.9
89.5
340
1265
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
931.3
81.2
77
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.0
72.8
164
248
CG2S4
NOMESCO Finland
Photography of cornea
665.0
60.2
58
*
H16.0
ICD-10 Finland
Corneal ulcer
41.5
58.6
73
21
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.9
49.1
140
282
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
45.6
43
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.2
44.1
136
298
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
472.9
44.0
43
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
43.5
41
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.2
42.5
239
982
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
436.2
40.8
40
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.8
36.7
101
186
H16.9
ICD-10 Finland
Keratitis, unspecified
134.5
35.3
37
*
ZXA10
NOMESCO Finland
Bilateral
4.1
32.9
160
545
TCG10
NOMESCO Finland
Removal of sutures from cornea
178.1
32.2
33
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.1
31.6
111
272
CGE10
NOMESCO Finland
Keratectomy
+∞
30.6
29
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.4
30.2
204
895
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
29.5
28
*
Z3229
NOMESCO Finland
Other healthcare associate professional
5.6
28.8
91
196
H18.6
ICD-10 Finland
Keratoconus
+∞
26.3
25
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.3
26.3
171
711
WX140
NOMESCO Finland
Parabulbar anesthesy
7.3
23.3
58
90
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
13.2
23.3
41
34
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
23.1
22
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.6
22.3
84
216
WX002
NOMESCO Finland
Sedation and analgesia
3.2
21.9
145
596
S01ED01
ATC
timolol; ophthalmic
8.9
21.3
46
57
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
19.9
19
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
19.9
19
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
19.9
19
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
18.9
18
*
S01ED51
ATC
timolol, combinations; ophthalmic
4.7
18.2
65
157
Z3231
NOMESCO Finland
Registered nurse
2.7
18.0
163
800
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
17.8
17
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
43.9
17.4
21
5
H26.4
ICD-10 Finland
After-cataract
3.9
16.8
75
223
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
16.8
16
*
ZXA05
NOMESCO Finland
Left side
2.6
16.5
156
774
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.4
16.0
61
157
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
15.7
15
*
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
15.7
15
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
15.7
15
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
14.5
15.7
26
19
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
14.7
14
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
14.7
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
14.3
101
417
S01EC01
ATC
acetazolamide; systemic
9.1
12.7
26
30
H18.2
ICD-10 Finland
Other corneal oedema
+∞
12.6
12
*
S01BC03
ATC
diclofenac; ophthalmic
8.2
12.3
27
35
ZXA00
NOMESCO Finland
Right side
2.2
12.3
152
841
S01AD03
ATC
aciclovir; ophthalmic
7.2
12.1
29
43
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
11.5
11
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
9.3
11.4
23
26
CD2S4
NOMESCO Finland
Photography of eye
36.1
11.3
14
*
XCK00
NOMESCO Finland
Perimetry
3.7
11.1
50
149
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
8.6
10.9
23
28
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
16.0
10.9
17
11
S01GX01
ATC
cromoglicic acid; ophthalmic
2.4
10.5
102
498
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
6.7
10.5
26
41
H16.2
ICD-10 Finland
Keratoconjunctivitis
112.6
10.5
11
*
H27.0
ICD-10 Finland
Aphakia
+∞
10.5
10
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
10.5
10
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
10.5
10
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
10.5
10
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.2
10.3
57
198
H57.1
ICD-10 Finland
Ocular pain
6.2
10.0
26
44
H52.2
ICD-10 Finland
Astigmatism
11.0
9.9
18
17
H11.0
ICD-10 Finland
Pterygium
26.7
9.9
13
5
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
12.7
9.4
16
13
H18.7
ICD-10 Finland
Other corneal deformities
+∞
9.4
9
*
S01FA01
ATC
atropine; ophthalmic
22.3
9.4
13
6
S01EA03
ATC
apraclonidine; ophthalmic
14.1
9.2
15
11
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.2
9.1
34
87
H26.2
ICD-10 Finland
Complicated cataract
9.8
8.8
17
18
H26.02
ICD-10 Finland
Presenil cataract
5.7
8.4
23
42
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
8.4
8
*
3604
FHL
Penetration of the cornea
+∞
8.4
8
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
8.4
8
*
ZXE00
NOMESCO Finland
One hour or less
1.8
8.3
185
1247
Z2221
NOMESCO Finland
Medical doctor
1.9
8.3
141
862
ZXD20
NOMESCO Finland
Day surgery
2.4
8.3
72
327
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.7
8.2
27
61
114
Kela drug reimbursment
Glaucoma
2.8
8.2
54
211
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
17.6
8.1
12
7
H54.4
ICD-10 Finland
Blindness, monocular
45.8
7.7
9
*
H3603, E103
ICD-10 Finland
NA
12.1
7.6
13
11
XCH00
NOMESCO Finland
Eye pressure measurement
3.8
7.5
31
87
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.5
183
1258
L04AA01
ATC
[U] ciclosporin; systemic
7.9
7.4
16
21
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
7.3
50
200
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
+∞
7.3
7
*
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
7.3
7
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
7.3
7
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
7.3
7
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.2
7.2
36
118
CHD99
NOMESCO Finland
Other filtering operation
30.6
7.2
9
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
9.0
7.1
14
16
H35.36
ICD-10 Finland
Macular cyst
17.0
6.8
10
6
S01EC03
ATC
dorzolamide; ophthalmic
10.2
6.6
12
12
H20
ICD-10 Finland
Iridocyclitis
70.8
6.4
7
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
6.4
163
1119
S01XA18
ATC
ciclosporin; ophthalmic
14.6
6.4
10
7
S01AX11
ATC
[U] ofloxacin; ophthalmic
4.1
6.4
23
58
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.4
6.3
29
90
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
6.3
60
287
3661A
ICD-9 Finland
Cataract, Senile cataract
18.3
6.3
9
5
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
6.3
6
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
6.3
6
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
6.3
6
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
6.3
6
*
H16.8
ICD-10 Finland
Other keratitis
+∞
6.3
6
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
5.0
6.1
18
37
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALDYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.201 [1.0, 1.44] | 0.048 |
| Birth year | 0.994 [0.99, 1.0] | 0.189 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 1316 females with H7_CORNEALDYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.171 [0.91, 1.51] | 0.228 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 781 males with H7_CORNEALDYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALDYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.305% |
| 5 | 0.783% | 1.513% |
| 10 | 1.754% | 3.959% |
| 15 | 3.484% | 7.537% |
| 20 | 5.907% | 13.452% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALDYSTROPHY – Corneal degeneration
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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