corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
145 |
4. Check minimum number of eventsNone |
145 |
5. Include endpointsNone |
145 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Pigmentationes et alia deposita corneae
Similar endpoints
↥List of similar endpoints to
Corneal pigmentations and deposits
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1538 | 814 | 709 |
| Only index persons | 1121 | 568 | 553 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.64 | 54.96 | 45.56 |
| Only index persons | 44.59 | 47.91 | 41.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 80 | 65 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 47.99 | 48.83 | 46.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 129
- Matched controls
- 1291
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
100.6
83
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
46.7
42
*
H16.0
ICD-10 Finland
Corneal ulcer
36.5
24.6
31
11
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
20.3
19
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.4
17.9
87
359
S01AD03
ATC
aciclovir; ophthalmic
20.7
16.4
24
14
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
16.0
15
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
13.8
13
*
H18.6
ICD-10 Finland
Keratoconus
+∞
13.8
13
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
12.7
12
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.8
11.7
70
307
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
11.6
11
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
11.6
11
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.1
10.9
37
94
S01ED01
ATC
timolol; ophthalmic
16.1
10.8
17
12
H04.10
ICD-10 Finland
Dry eye syndrome
5.9
10.7
31
65
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
119.3
10.6
11
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
7.0
10.0
25
43
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
9.5
9
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
9.5
9
*
S01AA12
ATC
tobramycin; ophthalmic
+∞
8.4
8
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
14.3
8.1
13
10
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
19.8
7.7
11
6
H26.4
ICD-10 Finland
After-cataract
5.4
7.7
23
50
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
84.8
7.5
8
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
7.4
7
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
7.4
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
7.1
32
105
XCK10
NOMESCO Finland
Photography of fundus of eye
4.4
6.9
25
67
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
6.8
25
68
C01BD01
ATC
amiodarone; systemic
8.1
6.6
14
19
H18.4
ICD-10 Finland
Corneal degeneration
+∞
6.3
6
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
6.3
6
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
6.3
6
*
3604
FHL
Penetration of the cornea
+∞
6.3
6
*
L04AA01
ATC
[U] ciclosporin; systemic
13.4
6.2
10
8
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEAPIGMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEAPIGMENT | 1.511 [1.03, 2.21] | 0.033 |
| Birth year | 0.996 [0.99, 1.0] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 385 females with H7_CORNEAPIGMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEAPIGMENT | 1.17 [0.8, 1.7] | 0.413 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 373 males with H7_CORNEAPIGMENT died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEAPIGMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.23% |
| 5 | 0.941% | 1.32% |
| 10 | 2.26% | 3.36% |
| 15 | 4.493% | 6.568% |
| 20 | 7.991% | 11.156% |
Relationships between endpoints
↥Index endpoint: H7_CORNEAPIGMENT – Corneal pigmentations and deposits
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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