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Corneal pigmentations and deposits

DOID EFO Endpoint Browser PheWeb

H7_CORNEAPIGMENT

Observable characteristics or traits involving the accumulation of pigmented material or deposits on the cornea, the transparent front part of the eye.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.0#
  • Hospital discharge: ICD-9 — 3711
  • Hospital discharge: ICD-8 — 37100
  • Cause of death: ICD-10 — H18.0#
  • Cause of death: ICD-9 — 3711
  • Cause of death: ICD-8 — 37100

2 out of 7 registries used, show all original rules.

152

4. Check minimum number of events

None

152

5. Include endpoints

None

152

6. Filter based on genotype QC (FinnGen only)

145

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Pigmentationes et alia deposita corneae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1538 814 709
Only index persons 1121 568 553
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.64 54.96 45.56
Only index persons 44.59 47.91 41.17

-FinnGen-

Key figures

All Female Male
Number of individuals 145 81 64
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 48.86 49.12 48.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
152
Matched controls
1520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
123.3
101
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
50.9
46
*
H16.0
ICD-10 Finland
Corneal ulcer
35.7
29.8
38
14
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
22.4
21
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.7
19.0
102
459
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
18.1
17
*
H04.10
ICD-10 Finland
Dry eye syndrome
5.4
16.9
40
94
S01AD03
ATC
aciclovir; ophthalmic
18.4
16.4
25
16
H18.6
ICD-10 Finland
Keratoconus
+∞
15.9
15
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
13.7
13
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
13.7
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
153.1
13.7
14
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
12.7
12
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.1
10.6
78
387
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.6
10.6
28
71
CG2T4
NOMESCO Finland
Topography assessment of cornea
117.8
10.6
11
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
117.8
10.6
11
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
10.5
10
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.7
10.3
40
135
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.7
8.7
32
103
S01ED01
ATC
timolol; ophthalmic
7.6
8.4
19
28
XCK10
NOMESCO Finland
Photography of fundus of eye
3.8
8.3
28
85
L04AA01
ATC
[U] ciclosporin
23.5
8.1
11
5
S01BA01
ATC
dexamethasone; ophthalmic
8.4
7.6
16
21
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
84.0
7.5
8
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
7.3
7
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
7.3
7
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
7.3
7
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
7.3
7
*
WX140
NOMESCO Finland
Parabulbar anesthesy
6.7
7.3
18
30
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
31.7
7.2
9
*
S01BA04
ATC
prednisolone; ophthalmic
12.9
7.2
12
10
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
7.0
40
167
H26.4
ICD-10 Finland
After-cataract
3.5
7.0
27
89
C01BD01
ATC
amiodarone; systemic
8.9
7.0
14
17
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.5
6.9
26
85
ZXA05
NOMESCO Finland
Left side
2.6
6.8
51
246
S01AA12
ATC
tobramycin; ophthalmic
23.7
6.8
9
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
6.3
6
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
6.3
6
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
6.3
6
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
6.3
6
*
3604
FHL
Penetration of the cornea
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
152
2.40
4.23
2.3
1.4
—
—
—
0
0
106
796
2.10
4.22
4.2
4.5
—
—
—
0
0
78
549
1.86
3.50
20.2
14.6
1.23
1.28
inr
0.15
16
177
6
8
7.75
3.08
1.2
1.4
—
—
—
0
0
53
345
1.82
2.95
3.4
3.4
—
—
—
0
0
110
889
1.86
2.92
4.3
3.9
13.03
11.84
mm/h
0.27
104
823
50
337
1.72
2.41
3.3
3.9
33.16
10.42
mg/mmol
0.50
30
213
48
321
1.72
2.38
3.1
4.2
—
—
—
0
0
76
579
1.63
2.27
5.3
5.3
0.00
0.00
estimate
-0.00
12
113
86
677
1.62
2.23
4.5
4.8
7.12
6.79
mmol/l
0.62
81
636
46
314
1.67
2.09
2.7
3.2
122.81
66.15
mg/l
0.31
27
203
5
10
5.13
2.08
1.0
1.1
—
—
—
0
0
74
582
1.53
1.80
3.9
3.9
0.00
0.01
estimate
0.50
13
121
105
892
1.57
1.79
4.4
4.0
15.63
14.79
pmol/l
2.44
100
820
7
24
3.01
1.74
1.1
1.0
—
—
—
0
0
61
464
1.53
1.72
4.6
4.0
37.75
51.99
ng/l
0.40
46
331
74
589
1.50
1.67
3.9
3.9
0.00
0.00
estimate
-0.00
12
107
78
630
1.49
1.62
7.4
6.1
9.92
11.43
umol/l
1.28
78
597
7
28
2.57
1.47
3.1
3.1
—
—
—
0
0
25
160
1.67
1.43
2.8
1.3
—
—
—
0
0
16
90
1.87
1.39
1.4
1.4
—
—
—
0
0
5
21
2.43
1.10
1.2
1.2
—
—
—
0
0
7
33
2.17
1.07
1.1
1.1
—
—
—
0
0
47
369
1.40
1.06
3.8
3.8
7.40
7.40
ph
0.05
11
82
22
314
0.65
1.06
1.3
1.4
—
—
—
0
0
24
165
1.54
1.05
2.5
2.0
—
—
—
0
0
30
217
1.48
1.04
1.6
1.8
1327.22
1278.48
nmol/l
0.11
23
164
27
191
1.50
1.04
3.0
2.9
4.48
3.21
e6/l
0.23
21
104
17
108
1.65
1.01
1.8
1.7
—
—
—
0
0
35
263
1.43
1.00
3.8
3.6
—
—
—
0
0
5
23
2.21
0.99
5.6
2.9
55.20
56.96
%
—
5
23
5
23
2.21
0.99
5.6
2.8
3.50
4.54
e9/l
—
5
23
72
612
1.34
0.97
9.2
5.4
1.82
2.03
e9/l
0.48
62
546
11
62
1.83
0.97
1.3
1.3
1165.11
162.61
u/ml
0.69
11
57
118
1081
1.41
0.96
5.3
4.8
1.84
1.94
mu/l
0.49
112
994
113
1028
1.39
0.96
22.6
17.1
14.57
14.68
%
0.09
113
1010
7
37
1.93
0.95
5.0
6.2
—
—
—
0
0
41
320
1.39
0.95
4.0
4.2
0.00
0.03
estimate
0.50
11
107
94
836
1.33
0.90
5.4
3.8
—
—
—
0
0
6
29
2.11
0.90
1.3
1.3
—
—
—
0
0
72
617
1.32
0.90
9.2
6.0
0.21
0.19
e9/l
0.49
62
547
11
64
1.77
0.89
2.8
3.7
25.89
24.73
mmol/l
0.35
11
64
14
88
1.65
0.88
9.1
7.5
—
—
—
0
0
134
1263
1.51
0.87
23.5
16.3
83.68
78.28
umol/l
0.68
134
1263
26
190
1.44
0.86
1.5
1.9
—
—
—
0
0
127
1186
1.43
0.86
19.4
14.1
21.82
22.13
mg/l
0.04
104
938
22
156
1.48
0.85
1.2
1.6
—
—
—
0
0
5
97
0.50
0.81
1.4
1.5
—
—
—
0
0
11
66
1.72
0.81
4.0
6.6
24.95
24.88
mmol/l
0.02
11
66
68
585
1.29
0.81
6.0
6.4
1.22
1.21
mmol/l
0.20
58
493
69
597
1.29
0.78
9.3
5.4
0.58
0.59
e9/l
0.02
59
517
65
559
1.28
0.77
9.0
5.9
—
—
—
0
0
69
598
1.28
0.76
9.3
5.4
0.04
0.04
e9/l
0.17
59
516
7
38
1.88
0.74
1.6
1.6
—
—
—
0
0
7
40
1.79
0.72
1.1
1.2
—
—
—
0
0
5
26
1.95
0.71
1.0
2.2
—
4.35
—
0
10
7
41
1.74
0.71
1.1
1.2
—
—
—
0
0
7
41
1.74
0.71
1.1
1.2
—
—
—
0
0
7
41
1.74
0.71
1.1
1.2
—
—
—
0
0
118
1103
1.31
0.67
7.0
5.9
40.90
40.22
mmol/mol
0.27
112
1035
18
131
1.42
0.62
1.4
1.5
—
—
—
0
0
5
30
1.69
0.62
1.8
3.2
8.92
7.67
mmol/l
—
5
30
5
30
1.69
0.62
2.0
1.3
—
—
—
0
0
5
30
1.69
0.62
1.8
3.2
1.88
1.41
mmol/l
—
5
30
40
332
1.28
0.61
3.3
2.9
0.81
0.37
e6/l
0.30
32
242
50
427
1.25
0.61
3.7
3.7
397.56
64.58
e6/l
0.64
37
302
10
64
1.60
0.60
4.3
4.4
—
—
—
0
0
38
453
0.79
0.60
3.5
3.1
—
—
—
0
0
29
358
0.77
0.60
4.1
4.2
—
—
—
0
0
8
53
1.54
0.59
1.9
1.2
—
—
—
0
0
39
324
1.27
0.59
2.9
2.8
—
—
—
0
0
13
91
1.47
0.55
3.1
3.4
—
—
—
0
0
6
38
1.60
0.55
1.2
1.2
—
—
—
0
0
27
216
1.30
0.54
3.1
3.7
12.75
113.87
ng/l
1.42
20
174
19
144
1.37
0.54
6.3
6.9
104.68
103.40
mmol/l
0.53
19
144
43
366
1.24
0.53
3.4
3.1
64.11
234.17
e6/l
0.46
34
278
121
1150
1.26
0.49
5.1
4.5
6.21
5.95
mmol/l
0.81
109
1049
30
248
1.26
0.48
2.7
3.1
548.75
537.45
mosm/kgh2o
0.10
24
206
7
51
1.39
0.44
2.4
4.8
—
—
—
0
0
42
480
0.83
0.44
2.4
2.1
—
—
—
0
0
53
470
1.20
0.44
2.2
2.0
86.16
97.76
pmol/l
1.54
33
229
30
252
1.24
0.42
2.4
2.6
4.82
4.07
e6/l
0.15
24
222
8
59
1.38
0.41
1.3
2.7
0.79
0.68
%
—
8
59
39
340
1.20
0.39
3.9
3.7
—
—
—
0
0
35
302
1.21
0.38
1.8
1.7
1.32
1.38
mmol/l
0.14
30
256
75
692
1.17
0.38
11.1
9.3
4.22
4.13
e9/l
0.14
68
604
9
71
1.28
0.37
1.0
1.3
—
—
—
0
0
129
1246
1.23
0.36
16.8
13.2
—
—
—
0
0
11
83
1.35
0.33
1.1
1.9
—
—
—
0
0
13
101
1.31
0.33
3.0
4.2
—
—
—
0
0
6
47
1.29
0.32
2.5
6.2
1.58
1.58
%
—
6
42
135
1313
1.25
0.32
28.4
21.0
39.19
40.12
%
0.87
121
1242
8
62
1.31
0.28
1.3
2.7
1.15
1.45
%
—
8
62
118
1139
1.16
0.28
4.0
3.9
1.57
1.29
mmol/l
0.66
109
1041
8
64
1.26
0.28
1.4
1.2
—
—
—
0
0
17
141
1.23
0.27
1.3
1.3
—
—
—
0
0
124
1202
1.17
0.27
5.5
4.8
2.52
2.72
mmol/l
1.87
117
1103
122
1183
1.16
0.25
4.7
4.4
4.50
4.61
mmol/l
0.49
115
1095
9
75
1.21
0.25
5.7
8.4
0.80
0.73
%
—
9
75
9
76
1.20
0.25
2.8
8.3
1.39
1.61
%
—
9
76
5
37
1.36
0.24
2.4
2.6
—
—
—
0
0
5
40
1.26
0.22
2.2
4.4
3.98
3.97
mmol/l
—
5
40
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
8.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
7.9
—
7.45
—
0
5
14
165
0.83
0.20
1.4
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
4.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
32
293
1.12
0.17
1.7
1.5
21.22
21.01
nmol/l
0.02
27
243
13
111
1.19
0.16
2.8
2.3
0.25
0.21
g/l
0.63
13
102
10
84
1.20
0.14
2.3
4.7
—
—
—
0
0
8
97
0.82
0.14
1.5
1.2
—
—
—
0
0
33
308
1.09
0.12
9.0
7.3
—
—
—
0
0
26
279
0.92
0.10
1.5
1.2
4.81
1.09
u/ml
—
7
74
22
203
1.10
0.10
1.2
1.3
14.19
29.76
iu/ml
—
10
73
18
195
0.91
0.08
1.4
1.3
2.38
10.25
u/ml
—
9
76
7
68
1.03
0.08
1.7
2.3
—
—
—
0
0
23
245
0.93
0.08
1.2
1.4
1.97
2.70
g/l
1.37
15
139
8
74
1.09
0.07
1.1
1.5
0.80
1.23
g/l
—
8
65
8
75
1.07
0.07
1.6
3.1
—
7.41
—
0
13
9
85
1.06
0.07
1.1
1.4
—
—
—
0
0
22
207
1.07
0.06
12.0
2.9
0.80
0.81
mmol/l
0.12
22
195
119
1177
1.05
0.05
4.5
4.3
1.46
1.46
mmol/l
0.02
112
1081
10
91
1.11
0.04
1.6
2.0
8.81
10.08
g/l
—
10
79
12
111
1.09
0.04
2.1
1.3
—
—
—
0
0
17
164
1.04
0.00
1.2
1.3
—
—
—
0
0
23
231
0.99
0.00
2.7
2.8
0.71
0.78
ug/l
0.24
17
145
38
381
1.00
0.00
3.1
2.2
—
—
—
0
0
11
115
0.95
0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
9
96
0.93
0.00
2.1
4.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
107.72
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
9.9
—
1016.78
—
0
9
0
9
0.00
-0.00
0.0
18.4
—
2217.89
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
86
0.93
-0.00
1.1
2.9
69.70
66.24
g/l
—
8
79
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.9
—
41.00
—
0
7
0
5
0.00
-0.00
0.0
2.0
—
3.62
—
0
5
0
9
0.00
-0.00
0.0
8.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
6.18
—
0
5
0
9
0.00
-0.00
0.0
2.0
—
66.78
—
0
9
54
540
1.00
-0.00
12.9
9.7
0.00
0.01
e9/l
0.58
45
443
9
99
0.90
-0.00
2.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
1.76
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
57.75
—
0
8
7
74
0.94
-0.00
1.0
2.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
76
0.92
-0.00
4.9
2.6
—
—
—
0
0
5
53
0.94
-0.00
1.8
3.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEAPIGMENT and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNEAPIGMENT 1.511 [1.03, 2.21] 0.033
Birth year 0.996 [0.99, 1.0] 0.39

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 385 females with H7_CORNEAPIGMENT died.

Males

Parameter HR [95% CI] p-value
H7_CORNEAPIGMENT 1.17 [0.8, 1.7] 0.413
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 373 males with H7_CORNEAPIGMENT died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEAPIGMENT.

N-year risk Females Males
1 0.182% 0.23%
5 0.941% 1.32%
10 2.26% 3.36%
15 4.493% 6.568%
20 7.991% 11.156%

Relationships between endpoints

↥

Index endpoint: H7_CORNEAPIGMENT – Corneal pigmentations and deposits

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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