≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Corneal pigmentations and deposits

DOID EFO Endpoint Browser PheWeb

H7_CORNEAPIGMENT

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.0#
  • Hospital discharge: ICD-9 — 3711
  • Hospital discharge: ICD-8 — 37100
  • Cause of death: ICD-10 — H18.0#
  • Cause of death: ICD-9 — 3711
  • Cause of death: ICD-8 — 37100

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

145

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Pigmentationes et alia deposita corneae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1538 814 709
Only index persons 1121 568 553
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.64 54.96 45.56
Only index persons 44.59 47.91 41.17

-FinnGen-

Key figures

All Female Male
Number of individuals 145 80 65
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 47.99 48.83 46.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
129
Matched controls
1291
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
100.6
83
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
46.7
42
*
H16.0
ICD-10 Finland
Corneal ulcer
36.5
24.6
31
11
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
20.3
19
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.4
17.9
87
359
S01AD03
ATC
aciclovir; ophthalmic
20.7
16.4
24
14
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
16.0
15
*
H18.6
ICD-10 Finland
Keratoconus
+∞
13.8
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
13.8
13
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
12.7
12
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.8
11.7
70
307
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
11.6
11
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
11.6
11
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.1
10.9
37
94
S01ED01
ATC
timolol; ophthalmic
16.1
10.8
17
12
H04.10
ICD-10 Finland
Dry eye syndrome
5.9
10.7
31
65
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
119.3
10.6
11
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
7.0
10.0
25
43
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
9.5
9
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
9.5
9
*
S01AA12
ATC
tobramycin; ophthalmic
+∞
8.4
8
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
14.3
8.1
13
10
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
19.8
7.7
11
6
H26.4
ICD-10 Finland
After-cataract
5.4
7.7
23
50
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
84.8
7.5
8
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
7.4
7
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
7.4
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
7.1
32
105
XCK10
NOMESCO Finland
Photography of fundus of eye
4.4
6.9
25
67
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
6.8
25
68
C01BD01
ATC
amiodarone; systemic
8.1
6.6
14
19
3604
FHL
Penetration of the cornea
+∞
6.3
6
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
6.3
6
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
6.3
6
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
6.3
6
*
L04AA01
ATC
[U] ciclosporin; systemic
13.4
6.2
10
8

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
752
2.13
4.21
4.2
4.6
—
—
—
0
0
30
142
2.40
4.00
2.3
1.4
—
—
—
0
0
67
451
1.90
3.51
10.2
8.8
1.2
1.3
inr
0.05
15
149
47
306
1.79
2.60
3.0
4.2
—
—
—
0
0
104
848
1.80
2.58
4.4
3.9
13.1
12.0
mm/h
0.24
98
783
49
325
1.77
2.54
3.4
3.5
—
—
—
0
0
5
8
6.42
2.39
1.2
1.4
—
—
—
0
0
73
553
1.64
2.27
5.4
5.4
0.0
0.0
estimate
0.00
12
103
5
10
5.13
2.09
1.0
1.1
—
—
—
0
0
47
327
1.65
1.99
3.3
4.2
27.1
10.7
mg/mmol
0.32
28
206
60
445
1.59
1.96
4.7
4.1
38.4
53.3
ng/l
0.40
45
317
71
550
1.57
1.92
3.7
4.0
0.0
0.0
estimate
0.00
11
108
100
842
1.60
1.85
4.5
4.0
15.8
14.8
pmol/l
2.91
95
773
7
24
3.01
1.74
1.1
1.0
—
—
—
0
0
71
560
1.52
1.71
4.0
4.0
0.0
0.0
estimate
0.00
12
97
43
306
1.58
1.63
2.6
3.2
107.1
68.1
mg/l
0.18
24
196
7
27
2.67
1.53
3.4
3.2
—
—
—
0
0
50
374
1.51
1.51
8.0
4.9
—
—
—
0
0
41
295
1.54
1.48
4.0
4.3
0.0
0.0
estimate
0.50
11
98
7
29
2.48
1.41
1.6
1.4
0.3
0.2
g/l
—
7
29
17
99
1.81
1.34
5.1
3.9
—
—
—
0
0
46
346
1.48
1.34
3.4
3.8
7.4
7.4
ph
0.06
11
76
30
206
1.58
1.31
1.6
1.8
1327.2
1279.6
nmol/l
0.11
23
158
24
157
1.63
1.28
2.6
2.0
—
—
—
0
0
5
20
2.55
1.16
5.6
2.1
55.2
56.3
%
—
5
20
5
20
2.55
1.16
5.6
2.0
3.5
4.5
e9/l
—
5
20
23
153
1.60
1.15
3.0
1.3
—
—
—
0
0
20
296
0.62
1.14
1.3
1.4
—
—
—
0
0
7
30
2.40
1.14
1.6
1.4
1.3
1.2
g/l
—
7
30
16
97
1.73
1.12
1.8
1.7
—
—
—
0
0
69
579
1.37
1.05
9.3
5.4
1.8
2.0
e9/l
0.49
59
511
112
1021
1.43
0.99
5.3
4.8
1.8
1.9
mu/l
0.43
106
936
90
794
1.35
0.96
5.4
3.9
—
—
—
0
0
6
30
2.04
0.88
1.2
1.1
—
—
—
0
0
66
564
1.31
0.85
9.4
5.3
0.6
0.6
e9/l
0.06
56
485
68
585
1.31
0.83
9.4
6.0
0.2
0.2
e9/l
0.34
58
518
66
566
1.30
0.82
9.4
5.3
0.0
0.0
e9/l
0.11
56
486
33
255
1.38
0.82
3.9
3.6
—
—
—
0
0
13
82
1.64
0.81
7.9
7.9
—
—
—
0
0
120
1124
1.39
0.75
20.1
14.3
22.6
22.5
mg/l
0.01
99
888
10
60
1.72
0.74
3.0
3.8
25.7
24.8
mmol/l
—
10
60
127
1203
1.45
0.72
24.0
16.4
82.7
78.6
umol/l
0.47
127
1203
9
58
1.59
0.71
1.3
1.3
1401.7
170.9
u/ml
—
9
53
27
342
0.74
0.67
4.3
4.2
—
—
—
0
0
10
62
1.66
0.67
3.9
6.9
25.1
25.0
mmol/l
—
10
62
5
28
1.81
0.67
2.0
1.3
—
—
—
0
0
27
210
1.35
0.65
3.1
3.7
12.8
115.8
ng/l
1.42
20
171
5
29
1.75
0.64
1.4
1.3
—
—
—
0
0
6
35
1.74
0.58
1.2
1.7
—
—
—
0
0
6
35
1.74
0.58
1.2
1.2
—
—
—
0
0
6
37
1.65
0.56
5.7
6.2
—
—
—
0
0
6
38
1.60
0.55
1.2
1.2
—
—
—
0
0
22
171
1.34
0.54
1.5
1.9
—
—
—
0
0
38
319
1.26
0.54
4.0
3.8
—
—
—
0
0
12
83
1.49
0.53
1.3
1.4
—
—
—
0
0
6
39
1.56
0.53
1.2
1.2
—
—
—
0
0
6
39
1.56
0.53
1.2
1.2
—
—
—
0
0
6
39
1.56
0.53
1.2
1.2
—
—
—
0
0
47
407
1.23
0.50
3.7
3.7
339.9
67.8
e6/l
0.46
34
287
13
93
1.44
0.50
3.0
4.2
—
—
—
0
0
36
421
0.81
0.48
3.4
3.1
—
—
—
0
0
72
654
1.20
0.47
11.3
9.3
4.3
4.1
e9/l
0.23
65
570
52
458
1.21
0.47
2.2
2.0
86.2
97.7
pmol/l
1.53
33
225
7
49
1.45
0.46
2.4
4.8
—
—
—
0
0
37
315
1.23
0.46
3.3
2.9
0.9
0.4
e6/l
0.32
29
228
12
86
1.43
0.46
3.2
3.5
—
—
—
0
0
28
231
1.26
0.46
2.6
2.9
535.4
555.0
mosm/kgh2o
0.18
22
191
115
1094
1.25
0.46
5.2
4.6
6.1
6.0
mmol/l
0.60
103
999
40
460
0.82
0.45
2.4
2.1
—
—
—
0
0
36
307
1.23
0.44
2.9
2.8
—
—
—
0
0
8
59
1.38
0.41
1.4
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
66.0
—
0
16
18
142
1.31
0.41
1.2
1.5
—
—
—
0
0
40
349
1.20
0.40
3.4
3.1
64.2
245.3
e6/l
0.47
31
265
111
1058
1.21
0.39
6.9
6.0
40.4
40.4
mmol/mol
0.01
105
993
9
66
1.39
0.39
1.0
1.3
—
—
—
0
0
10
72
1.42
0.38
1.1
2.0
—
—
—
0
0
28
237
1.22
0.37
2.5
2.6
5.0
4.2
e6/l
0.16
22
205
17
136
1.28
0.35
1.3
1.2
—
—
—
0
0
6
89
0.66
0.34
1.5
1.2
—
—
—
0
0
106
1014
1.17
0.32
22.6
15.0
39.2
40.1
%
0.44
66
728
7
52
1.36
0.31
2.0
1.2
—
—
—
0
0
122
1182
1.20
0.30
17.4
13.3
—
—
—
0
0
33
291
1.17
0.29
1.8
1.7
1.4
1.4
mmol/l
0.05
28
246
8
62
1.31
0.28
4.8
4.5
—
—
—
0
0
13
158
0.81
0.25
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
8.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
10
80
1.27
0.21
2.3
4.8
—
—
—
0
0
0
13
0.00
0.21
0.0
7.9
—
7.5
—
0
5
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
4.9
—
—
—
0
0
117
1142
1.13
0.18
5.5
4.9
2.5
2.7
mmol/l
1.73
110
1047
7
60
1.17
0.18
1.3
2.7
1.3
1.3
%
—
7
60
111
1081
1.11
0.17
4.0
3.9
1.6
1.3
mmol/l
0.69
103
987
115
1123
1.12
0.17
4.7
4.4
4.5
4.6
mmol/l
0.42
108
1039
8
71
1.13
0.16
1.1
1.5
0.8
1.2
g/l
—
8
62
8
71
1.13
0.16
6.0
8.6
0.8
0.7
%
—
8
71
8
72
1.12
0.16
2.6
8.6
1.6
1.6
%
—
8
72
10
83
1.22
0.16
2.6
2.1
11.9
14.4
nmol/l
—
10
78
14
122
1.16
0.14
1.4
1.5
—
—
—
0
0
12
104
1.17
0.13
3.0
2.2
0.2
0.2
g/l
0.55
12
95
5
44
1.14
0.10
2.8
6.6
1.5
1.6
%
—
5
39
10
87
1.16
0.09
1.6
2.1
8.8
10.0
g/l
—
10
75
21
194
1.10
0.09
1.1
1.3
14.2
30.9
iu/ml
—
10
69
24
257
0.92
0.09
1.4
1.2
4.8
1.1
u/ml
—
7
69
21
195
1.09
0.08
12.5
2.9
0.8
0.8
mmol/l
0.43
21
185
27
254
1.08
0.08
6.2
4.9
—
—
—
0
0
17
156
1.10
0.08
1.2
1.2
—
—
—
0
0
7
65
1.08
0.08
1.7
2.3
—
—
—
0
0
17
184
0.91
0.08
1.4
1.3
2.4
10.7
u/ml
—
9
72
6
72
0.83
0.08
5.0
2.7
—
—
—
0
0
8
73
1.10
0.07
1.6
3.2
—
7.4
—
0
12
9
83
1.09
0.07
1.1
1.3
—
—
—
0
0
21
224
0.93
0.07
1.1
1.4
2.0
2.7
g/l
1.34
14
128
10
106
0.94
0.01
1.2
1.4
—
—
—
0
0
112
1119
1.00
0.00
4.5
4.3
1.5
1.5
mmol/l
0.08
105
1027
11
107
1.03
0.00
2.2
1.3
—
—
—
0
0
51
511
1.00
0.00
13.1
9.7
0.0
0.0
e9/l
0.58
42
415
23
227
1.02
0.00
2.7
2.9
0.7
0.8
ug/l
0.27
17
143
36
363
0.99
0.00
3.2
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
52
0.96
0.00
1.8
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
3.6
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
4.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
19.6
—
2291.4
—
0
8
8
82
0.97
0.00
1.1
3.0
69.7
66.0
g/l
—
8
75
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
10.0
—
1056.5
—
0
8
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
9
92
0.98
0.00
2.1
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
29
290
1.00
0.00
9.9
7.1
—
—
—
0
0
0
7
0.00
0.00
0.0
5.9
—
41.0
—
0
7
0
7
0.00
0.00
0.0
2.7
—
12.6
—
0
7
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
92
0.98
0.00
2.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
1.8
—
0
8
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
0.00
0.0
8.9
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEAPIGMENT and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNEAPIGMENT 1.511 [1.03, 2.21] 0.033
Birth year 0.996 [0.99, 1.0] 0.39

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 385 females with H7_CORNEAPIGMENT died.

Males

Parameter HR [95% CI] p-value
H7_CORNEAPIGMENT 1.17 [0.8, 1.7] 0.413
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 373 males with H7_CORNEAPIGMENT died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEAPIGMENT.

N-year risk Females Males
1 0.182% 0.23%
5 0.941% 1.32%
10 2.26% 3.36%
15 4.493% 6.568%
20 7.991% 11.156%

Relationships between endpoints

↥

Index endpoint: H7_CORNEAPIGMENT – Corneal pigmentations and deposits

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data