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Other corneal oedema

DOID EFO Endpoint Browser PheWeb

H7_CORNEALOEDEMA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.2
  • Hospital discharge: ICD-9 — 3712
  • Cause of death: ICD-10 — H18.2
  • Cause of death: ICD-9 — 3712

2 out of 7 registries used, show all original rules.

255

4. Check minimum number of events

None

255

5. Include endpoints

None

255

6. Filter based on genotype QC (FinnGen only)

255

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Aliud oedema corneae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2050 1197 844
Only index persons 1836 1082 754
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 73.26 75.52 70.07
Only index persons 72.97 75.20 69.78

-FinnGen-

Key figures

All Female Male
Number of individuals 255 143 112
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 70.47 70.90 69.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
214
Matched controls
2138
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.2
ICD-10 Finland
Other corneal oedema
+∞
290.3
207
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
16.9
69.9
133
189
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
9.2
46.9
164
564
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
45.5
42
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
36.5
34
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
6.7
36.2
154
593
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
35.4
33
*
H16.0
ICD-10 Finland
Corneal ulcer
38.6
32.7
41
13
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
31.0
29
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
31.0
29
*
WX140
NOMESCO Finland
Parabulbar anesthesy
16.0
29.5
49
39
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
27.1
150
677
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.1
25.4
69
134
S01ED51
ATC
timolol, combinations; ophthalmic
9.1
24.7
55
78
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
24.4
23
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
24.4
23
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
140.8
24.1
25
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.9
23.4
75
179
H25.1
ICD-10 Finland
Senile nuclear cataract
4.4
23.2
121
484
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
21.2
20
*
CG2S4
NOMESCO Finland
Photography of cornea
+∞
21.2
20
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
122.0
21.0
22
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.1
19.9
73
198
XCK10
NOMESCO Finland
Photography of fundus of eye
6.5
19.6
55
108
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
14.2
19.4
33
27
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
19.0
18
*
H18.6
ICD-10 Finland
Keratoconus
207.4
18.8
19
*
S01ED01
ATC
timolol; ophthalmic
12.4
18.2
33
31
S01EC01
ATC
acetazolamide; systemic
15.1
17.0
28
21
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
43.9
16.6
20
5
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
15.8
15
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
172.1
15.7
16
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
15.1
44
89
ZXA05
NOMESCO Finland
Left side
3.5
14.9
91
377
XCK00
NOMESCO Finland
Perimetry
6.5
14.2
38
69
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
80.4
13.8
15
*
S01EA03
ATC
apraclonidine; ophthalmic
36.7
13.7
17
5
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
21.7
12.7
18
9
H18.4
ICD-10 Finland
Corneal degeneration
+∞
12.6
12
*
ZXA00
NOMESCO Finland
Right side
3.1
12.3
90
409
114
Kela drug reimbursment
Glaucoma
4.5
12.2
46
123
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
63.2
10.7
12
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
8.3
10.2
22
29
WX002
NOMESCO Finland
Sedation and analgesia
3.0
10.1
68
287
H26.4
ICD-10 Finland
After-cataract
3.7
10.0
46
147
H26.2
ICD-10 Finland
Complicated cataract
21.3
9.9
14
7
S01AD03
ATC
aciclovir; ophthalmic
9.8
9.7
19
21
H26.02
ICD-10 Finland
Presenil cataract
10.8
9.7
18
18
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
9.5
43
135
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
9.4
9
*
ZXA10
NOMESCO Finland
Bilateral
2.9
9.4
64
271
S01EC03
ATC
dorzolamide; ophthalmic
16.5
9.2
14
9
CHD99
NOMESCO Finland
Other filtering operation
38.5
9.1
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.2
9.0
35
96
S01EC04
ATC
brinzolamide; ophthalmic
6.2
8.7
23
41
CKD60
NOMESCO Finland
Anterior vitrectomy
21.1
8.6
12
6
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
93.6
8.5
9
*
S01EE05
ATC
tafluprost; ophthalmic
6.8
8.2
20
32
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.2
7.9
24
51
H40.0
ICD-10 Finland
Glaucoma suspect
3.9
7.7
31
88
3712A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal oedema
+∞
7.3
7
*
3604
FHL
Penetration of the cornea
+∞
7.3
7
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
7.3
7
*
S01EE03
ATC
bimatoprost; ophthalmic
7.1
7.0
16
24
S01EE01
ATC
latanoprost; ophthalmic
3.8
6.8
28
81
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.4
6.8
8
*
S01AA12
ATC
tobramycin; ophthalmic
41.4
6.8
8
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
23.4
6.7
9
*
S01FA01
ATC
atropine; ophthalmic
71.9
6.5
7
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
71.9
6.5
7
*
H27.0
ICD-10 Finland
Aphakia
71.9
6.5
7
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
71.9
6.5
7
*
S01EE04
ATC
travoprost; ophthalmic
6.9
6.5
15
23
WX142
NOMESCO Finland
Sub-tenon anesthesy
18.7
6.3
9
5
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
6.3
6
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
6.3
6
*
S01EB01
ATC
pilocarpine; ophthalmic
13.0
6.1
10
8

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
247
3.06
12.19
2.4
1.5
—
—
—
0
0
107
645
2.14
7.81
6.9
5.1
—
—
—
0
0
153
1104
1.96
6.35
8.1
6.3
1.2
1.2
mmol/l
0.74
127
924
102
643
1.98
6.29
3.3
3.1
6.3
7.1
mmol/l
1.23
87
528
143
1011
1.94
6.28
7.1
5.5
1.2
1.2
mmol/l
0.99
122
921
191
1502
2.08
6.05
3.9
4.1
14.9
15.0
pmol/l
0.26
174
1342
211
1727
2.29
5.97
22.6
16.4
37.5
39.3
%
1.11
123
1142
98
626
1.92
5.70
3.4
3.2
728.7
251.7
mg/l
0.31
66
408
129
902
1.87
5.66
2.2
2.0
94.5
96.2
pmol/l
0.14
61
451
119
822
1.84
5.34
2.3
2.3
—
—
—
0
0
240
2112
3.32
5.34
12.7
10.6
23.4
24.5
u/l
0.70
226
2025
100
656
1.86
5.28
4.0
4.0
10.0
8.7
mg/mmol
0.10
65
416
237
2084
2.94
5.03
25.1
18.4
139.3
139.6
mmol/l
0.55
232
2028
216
1828
2.19
4.93
5.0
4.9
2.2
2.0
mu/l
1.46
197
1632
177
1404
1.85
4.85
5.2
4.5
—
—
—
0
0
182
1468
1.84
4.58
4.9
4.2
—
—
—
0
0
146
1107
1.75
4.52
6.8
5.8
10.2
11.3
umol/l
0.95
136
1041
128
948
1.70
4.22
5.4
4.1
34.8
35.0
g/l
0.23
115
881
72
455
1.81
4.14
2.0
1.7
1358.9
1229.1
nmol/l
0.48
51
346
236
2111
2.58
4.08
23.6
18.5
86.4
79.6
umol/l
1.03
236
2111
232
2061
2.39
4.05
21.5
14.7
—
—
—
0
0
123
910
1.68
4.00
11.9
8.8
1.4
1.3
inr
0.72
31
271
133
1005
1.68
3.99
4.9
4.3
0.0
0.0
estimate
0.00
19
196
133
1006
1.67
3.97
7.3
5.1
0.6
0.6
e9/l
0.44
110
863
159
1263
1.69
3.91
5.8
4.5
7.2
6.8
mmol/l
0.96
149
1184
133
1009
1.66
3.90
7.3
5.1
0.0
0.0
e9/l
0.22
112
871
241
2185
2.88
3.90
31.2
22.8
245.8
243.3
e9/l
0.24
234
2127
241
2186
2.87
3.88
31.2
22.9
4.4
4.4
e12/l
1.41
234
2119
241
2187
2.86
3.85
31.2
22.9
6.9
6.7
e9/l
0.30
233
2122
136
1041
1.66
3.83
7.7
5.4
0.2
0.2
e9/l
0.04
114
911
134
1027
1.64
3.71
5.1
4.3
0.0
0.0
estimate
0.00
18
191
222
1956
2.04
3.67
5.6
4.9
6.1
6.1
mmol/l
0.32
205
1763
222
1957
2.04
3.65
4.7
4.7
4.5
4.6
mmol/l
0.43
201
1779
122
916
1.64
3.65
7.9
5.2
0.7
0.6
%
0.40
111
848
225
1994
2.09
3.63
21.2
15.5
25.4
24.2
mg/l
0.24
187
1602
189
1589
1.73
3.60
8.3
7.3
81.8
80.0
u/l
0.11
176
1481
7
9
7.96
3.58
1.0
1.2
—
—
—
0
0
133
1026
1.62
3.53
7.4
5.2
1.7
1.9
e9/l
0.95
113
901
69
450
1.73
3.51
5.9
5.2
1.0
1.0
kg/l
0.49
13
66
132
1018
1.62
3.50
6.0
5.7
0.0
0.0
estimate
0.00
18
188
49
289
1.86
3.47
7.4
4.9
1.0
1.0
mmol/l
0.05
43
257
124
945
1.61
3.43
7.6
5.1
2.7
2.8
%
0.20
112
877
67
437
1.72
3.39
6.3
3.6
446.9
192.5
ng/l
0.31
56
365
80
548
1.67
3.38
2.5
2.1
3.1
3.2
mg/l
0.12
71
473
45
262
1.87
3.32
5.9
6.1
1.0
1.4
mmol/l
0.32
31
217
124
951
1.59
3.30
7.9
5.5
9.0
8.6
%
0.73
113
891
92
659
1.62
3.24
3.4
2.5
56.8
56.4
u/l
0.04
83
611
102
751
1.60
3.20
3.3
3.2
2.4
2.4
mmol/l
0.02
85
647
23
105
2.31
3.20
8.0
7.0
—
—
—
0
0
84
595
1.61
3.07
4.0
4.0
—
—
—
0
0
39
225
1.87
2.96
2.1
2.4
6.4
8.5
umol/l
0.47
28
193
223
2004
1.90
2.95
5.6
5.3
2.5
2.7
mmol/l
1.15
199
1810
69
472
1.63
2.89
5.3
4.2
—
—
—
0
0
124
974
1.53
2.84
8.1
5.4
25.8
26.8
%
0.42
113
899
94
695
1.56
2.83
5.4
4.2
7.4
7.4
ph
0.40
13
133
5
6
8.47
2.76
1.2
1.0
—
—
—
0
0
55
362
1.66
2.66
4.2
2.8
0.8
0.8
mmol/l
0.07
47
335
96
722
1.53
2.65
3.2
3.3
—
—
—
0
0
109
844
1.51
2.61
3.6
2.7
164.5
135.3
ug/l
0.40
101
769
145
1192
1.50
2.60
9.8
8.7
4.1
4.2
e9/l
0.14
126
1042
90
671
1.53
2.57
2.3
2.0
119.2
227.5
u/l
2.74
83
630
216
1944
1.73
2.55
4.8
4.6
1.5
1.5
mmol/l
0.04
195
1754
121
962
1.49
2.53
7.8
5.1
58.7
58.3
%
0.13
108
899
176
1511
1.53
2.53
4.9
4.2
15.7
13.4
mm/h
0.96
160
1378
69
492
1.55
2.39
2.0
1.8
110345238.4
454.6
pmol/l
0.49
58
398
47
311
1.63
2.22
27.9
25.7
2.2
1.3
inr
—
6
34
111
887
1.45
2.18
4.8
4.0
36.9
42.7
ng/l
0.20
77
672
208
1883
1.57
2.06
4.3
4.2
1.3
1.3
mmol/l
0.29
187
1689
28
164
1.79
2.05
3.5
4.3
—
—
—
0
0
9
32
2.88
2.02
1.9
3.0
—
—
—
0
0
75
568
1.45
1.91
5.8
4.6
0.0
0.0
estimate
0.00
19
187
97
772
1.41
1.89
4.4
4.0
383.1
83.5
e6/l
0.59
68
560
9
35
2.63
1.82
2.8
3.3
56.0
62.7
%
—
9
35
13
60
2.23
1.81
1.4
1.2
—
—
—
0
0
207
1890
1.51
1.78
7.3
6.3
42.5
40.7
mmol/mol
1.43
189
1738
73
560
1.43
1.73
1.6
1.6
25.8
21.4
nmol/l
0.96
60
468
79
619
1.40
1.65
3.7
3.3
0.7
0.5
e6/l
0.25
60
463
24
146
1.71
1.57
5.8
3.2
—
—
—
0
0
29
186
1.63
1.57
3.9
3.1
66.0
66.6
g/l
0.14
23
167
29
188
1.61
1.51
3.2
3.7
112.1
82.3
ng/l
0.74
22
168
44
314
1.48
1.51
3.6
2.3
23.1
21.3
%
0.26
34
270
48
639
0.69
1.48
3.6
3.2
—
—
—
0
0
68
529
1.39
1.47
7.1
6.3
—
—
—
0
0
26
166
1.63
1.44
1.9
1.6
—
—
—
0
0
25
159
1.63
1.41
4.0
2.6
—
—
—
0
0
5
124
0.39
1.40
1.4
1.4
—
—
—
0
0
41
294
1.47
1.38
1.3
1.2
—
—
—
0
0
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
6
24
2.53
1.31
1.5
1.4
—
—
—
0
0
8
35
2.33
1.28
2.0
2.8
4.3
5.1
e9/l
—
8
35
29
197
1.53
1.26
1.8
2.1
114.5
154.4
ug/g
0.42
23
154
12
63
1.95
1.25
2.9
3.0
—
—
—
0
0
16
93
1.77
1.24
3.9
3.6
—
—
—
0
0
56
434
1.37
1.24
2.0
1.7
1.3
1.3
mg/l
0.02
43
346
18
110
1.68
1.19
3.8
4.2
—
—
—
0
0
5
20
2.53
1.15
1.6
1.2
—
—
—
0
0
5
20
2.53
1.15
1.2
1.3
—
—
—
0
0
82
683
1.30
1.11
3.9
3.4
149.3
149.7
e6/l
0.00
63
521
21
137
1.58
1.09
1.0
1.2
—
—
—
0
0
40
300
1.40
1.08
2.8
1.8
—
—
—
0
0
14
82
1.75
1.07
3.1
3.1
—
—
—
0
0
28
197
1.47
1.05
5.8
2.5
71.0
71.4
e9/l
0.02
22
165
32
232
1.43
1.04
1.8
1.7
—
—
—
0
0
5
22
2.30
1.04
1.0
1.1
—
—
—
0
0
12
68
1.80
1.02
3.4
2.1
—
—
—
0
0
27
190
1.47
1.02
1.8
1.6
—
—
—
0
0
79
665
1.27
0.97
2.4
2.2
—
—
—
0
0
30
218
1.43
0.97
3.2
3.3
1.7
2.0
mmol/l
0.18
25
171
72
600
1.28
0.96
3.9
3.2
—
—
—
0
0
30
220
1.41
0.93
3.2
3.4
5.7
5.8
kpa
0.07
30
211
26
187
1.43
0.89
2.5
2.5
4.2
4.2
kpa
0.03
26
178
8
45
1.80
0.85
2.5
3.4
—
—
—
0
0
65
545
1.26
0.82
3.6
2.7
368.9
7787.7
umol/l
2.87
57
454
35
272
1.33
0.78
4.5
2.5
2.2
1.8
%
0.90
29
247
20
142
1.44
0.75
9.4
6.6
1.1
1.5
%
1.38
20
142
51
421
1.26
0.74
5.5
5.2
—
—
—
0
0
27
205
1.35
0.71
6.3
3.7
—
—
—
0
0
33
261
1.30
0.67
2.8
4.0
3.2
49.1
ug/l
0.92
28
223
5
28
1.80
0.66
1.0
1.0
—
—
—
0
0
11
70
1.60
0.66
3.9
4.5
—
—
—
0
0
8
49
1.65
0.62
2.1
2.2
—
—
—
0
0
53
449
1.23
0.62
3.0
2.9
546.2
542.9
mosm/kgh2o
0.03
46
383
5
30
1.68
0.61
1.2
1.5
—
—
—
0
0
5
30
1.68
0.61
1.0
1.5
—
—
—
0
0
22
166
1.36
0.61
3.8
4.2
1.1
1.0
%
—
8
58
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
6
36
1.68
0.57
1.0
1.2
—
224.8
—
0
13
24
186
1.32
0.57
9.4
6.0
—
—
—
0
0
27
213
1.30
0.57
3.3
2.3
3.9
7.3
ug/l
1.36
21
191
15
107
1.43
0.56
1.1
1.4
—
—
—
0
0
10
65
1.56
0.56
1.6
1.6
—
—
—
0
0
61
530
1.20
0.56
1.6
1.6
1.3
1.3
mmol/l
0.01
55
439
44
372
1.22
0.53
1.5
1.4
2.9
2.6
g/l
0.38
18
200
6
39
1.55
0.53
1.3
1.2
1.0
216.9
e6/l
—
6
32
6
39
1.55
0.53
1.7
1.7
59.9
60.4
%
—
6
39
6
39
1.55
0.53
1.2
1.1
2.0
2.1
e6/l
—
6
32
55
476
1.20
0.53
3.1
2.7
7.5
4.9
e6/l
0.75
49
422
14
100
1.42
0.53
5.1
4.8
—
—
—
0
0
31
252
1.26
0.53
1.6
1.4
—
—
—
0
0
64
562
1.19
0.53
4.3
3.9
—
—
—
0
0
24
189
1.30
0.52
6.1
3.7
—
—
—
0
0
7
49
1.44
0.46
1.1
1.7
—
—
—
0
0
97
890
1.15
0.45
14.2
9.9
0.0
0.0
e9/l
0.54
83
727
17
130
1.33
0.45
2.8
2.6
3.8
3.7
e9/l
—
10
98
15
113
1.35
0.43
2.7
2.4
—
—
—
0
0
5
31
1.62
0.43
5.0
1.6
30.2
32.4
pg
—
5
31
5
32
1.57
0.42
2.0
1.2
11.3
9.4
u/l
—
5
26
8
58
1.39
0.42
4.6
4.6
28.0
29.3
mg/l
—
8
35
55
487
1.16
0.42
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
8
59
1.37
0.41
3.9
5.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
11.1
—
0
16
0
16
0.00
0.41
0.0
5.6
—
—
—
0
0
5
35
1.44
0.39
3.6
1.1
—
—
—
0
0
14
107
1.33
0.38
2.9
3.0
4.7
4.5
pmol/l
0.33
14
94
27
227
1.21
0.36
1.4
1.3
—
—
—
0
0
6
41
1.47
0.36
5.3
2.5
—
—
—
0
0
22
181
1.24
0.36
1.3
1.6
—
—
—
0
0
47
418
1.15
0.34
1.3
1.2
6.5
1.0
u/ml
—
8
104
18
147
1.24
0.31
4.3
4.3
0.0
0.2
%
—
5
43
7
54
1.30
0.30
2.6
2.3
7.9
7.7
kpa
—
7
48
10
75
1.35
0.30
3.0
2.0
39.4
37.8
g/l
—
5
65
70
645
1.12
0.30
4.8
5.0
1.8
2.8
ug/l
1.13
62
570
15
121
1.25
0.29
1.5
2.4
1.2
1.3
%
0.07
15
121
14
112
1.26
0.29
1.4
1.3
—
—
—
0
0
18
150
1.22
0.27
4.3
4.4
0.0
0.2
%
—
5
48
8
66
1.22
0.27
11.0
14.3
—
—
—
0
0
70
653
1.10
0.24
4.9
4.2
—
—
—
0
0
49
449
1.11
0.24
3.6
2.8
2.5
2.5
mmol/l
0.42
44
388
5
42
1.19
0.21
3.6
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
69.1
—
0
6
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.17
0.21
3.6
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
21
185
1.15
0.18
1.6
1.4
—
—
—
0
0
7
58
1.21
0.18
1.6
1.4
—
—
—
0
0
7
60
1.17
0.18
7.9
3.1
7.4
7.4
ph
—
7
48
11
93
1.19
0.14
1.2
1.2
—
—
—
0
0
29
266
1.10
0.14
1.5
1.3
—
—
—
0
0
35
376
0.92
0.14
3.2
2.9
0.6
0.9
ug/l
2.07
28
244
15
166
0.90
0.10
1.5
1.5
—
—
—
0
0
5
44
1.14
0.10
3.8
1.3
—
—
—
0
0
5
44
1.14
0.10
3.6
1.3
—
—
—
0
0
5
44
1.14
0.10
3.6
1.2
—
—
—
0
0
32
302
1.07
0.09
1.2
1.3
2.0
9.2
u/ml
1.45
11
111
17
180
0.94
0.04
3.7
4.1
—
—
—
0
0
10
109
0.91
0.04
1.0
1.4
—
—
—
0
0
17
162
1.05
0.02
1.6
1.4
—
—
—
0
0
34
337
1.01
0.00
1.3
1.2
25.6
36.3
iu/ml
—
8
109
10
103
0.97
0.00
2.3
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
19.4
—
0
7
0
7
0.00
0.00
0.0
1.6
—
19.0
—
0
7
9
97
0.93
0.00
2.1
1.6
—
—
—
0
0
7
69
1.01
0.00
1.1
1.1
—
—
—
0
0
6
66
0.91
0.00
5.3
2.0
20.5
20.6
s
—
6
61
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
34.3
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEALOEDEMA and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNEALOEDEMA 0.913 [0.77, 1.09] 0.307
Birth year 0.991 [0.98, 1.0] 0.037

During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 903 females with H7_CORNEALOEDEMA died.

Males

Parameter HR [95% CI] p-value
H7_CORNEALOEDEMA 1.047 [0.8, 1.37] 0.737
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 602 males with H7_CORNEALOEDEMA died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEALOEDEMA.

N-year risk Females Males
1 0.082% 0.206%
5 0.425% 1.229%
10 1.105% 3.074%
15 2.166% 5.816%
20 4.016% 9.612%

Relationships between endpoints

↥

Index endpoint: H7_CORNEALOEDEMA – Other corneal oedema

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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