corneal edema: Hazy, swollen cornea.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
255 |
4. Check minimum number of eventsNone |
255 |
5. Include endpointsNone |
255 |
6. Filter based on genotype QC (FinnGen only) |
255 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Aliud oedema corneae
Similar endpoints
↥List of similar endpoints to
Other corneal oedema
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2050 | 1197 | 844 |
| Only index persons | 1836 | 1082 | 754 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.26 | 75.52 | 70.07 |
| Only index persons | 72.97 | 75.20 | 69.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 255 | 143 | 112 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 70.47 | 70.90 | 69.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 214
- Matched controls
- 2138
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.2
ICD-10 Finland
Other corneal oedema
+∞
290.3
207
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
16.9
69.9
133
189
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
9.2
46.9
164
564
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
45.5
42
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
36.5
34
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
6.7
36.2
154
593
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
35.4
33
*
H16.0
ICD-10 Finland
Corneal ulcer
38.6
32.7
41
13
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
31.0
29
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
+∞
31.0
29
*
WX140
NOMESCO Finland
Parabulbar anesthesy
16.0
29.5
49
39
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
27.1
150
677
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.1
25.4
69
134
S01ED51
ATC
timolol, combinations; ophthalmic
9.1
24.7
55
78
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
24.4
23
*
H16.9
ICD-10 Finland
Keratitis, unspecified
+∞
24.4
23
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
140.8
24.1
25
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.9
23.4
75
179
H25.1
ICD-10 Finland
Senile nuclear cataract
4.4
23.2
121
484
CG2S4
NOMESCO Finland
Photography of cornea
+∞
21.2
20
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
21.2
20
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
122.0
21.0
22
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.1
19.9
73
198
XCK10
NOMESCO Finland
Photography of fundus of eye
6.5
19.6
55
108
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
14.2
19.4
33
27
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
19.0
18
*
H18.6
ICD-10 Finland
Keratoconus
207.4
18.8
19
*
S01ED01
ATC
timolol; ophthalmic
12.4
18.2
33
31
S01EC01
ATC
acetazolamide; systemic
15.1
17.0
28
21
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
43.9
16.6
20
5
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
15.8
15
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
172.1
15.7
16
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
15.1
44
89
ZXA05
NOMESCO Finland
Left side
3.5
14.9
91
377
XCK00
NOMESCO Finland
Perimetry
6.5
14.2
38
69
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
80.4
13.8
15
*
S01EA03
ATC
apraclonidine; ophthalmic
36.7
13.7
17
5
Z3229
NOMESCO Finland
Other healthcare associate professional
5.0
13.1
44
105
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
21.7
12.7
18
9
H18.4
ICD-10 Finland
Corneal degeneration
+∞
12.6
12
*
ZXA00
NOMESCO Finland
Right side
3.1
12.3
90
409
114
Kela drug reimbursment
Glaucoma
4.5
12.2
46
123
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
63.2
10.7
12
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
8.3
10.2
22
29
WX002
NOMESCO Finland
Sedation and analgesia
3.0
10.1
68
287
H26.4
ICD-10 Finland
After-cataract
3.7
10.0
46
147
H26.2
ICD-10 Finland
Complicated cataract
21.3
9.9
14
7
S01AD03
ATC
aciclovir; ophthalmic
9.8
9.7
19
21
H26.02
ICD-10 Finland
Presenil cataract
10.8
9.7
18
18
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
9.5
43
135
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
9.4
9
*
ZXA10
NOMESCO Finland
Bilateral
2.9
9.4
64
271
S01EC03
ATC
dorzolamide; ophthalmic
16.5
9.2
14
9
CHD99
NOMESCO Finland
Other filtering operation
38.5
9.1
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.2
9.0
35
96
S01EC04
ATC
brinzolamide; ophthalmic
6.2
8.7
23
41
CKD60
NOMESCO Finland
Anterior vitrectomy
21.1
8.6
12
6
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
93.6
8.5
9
*
S01EE05
ATC
tafluprost; ophthalmic
6.8
8.2
20
32
ZXD20
NOMESCO Finland
Day surgery
3.5
8.2
39
128
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.2
7.9
24
51
H40.0
ICD-10 Finland
Glaucoma suspect
3.9
7.7
31
88
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
7.3
7
*
3604
FHL
Penetration of the cornea
+∞
7.3
7
*
3712A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal oedema
+∞
7.3
7
*
Z3231
NOMESCO Finland
Registered nurse
2.3
7.0
75
401
S01EE03
ATC
bimatoprost; ophthalmic
7.1
7.0
16
24
S01EE01
ATC
latanoprost; ophthalmic
3.8
6.8
28
81
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.4
6.8
8
*
S01AA12
ATC
tobramycin; ophthalmic
41.4
6.8
8
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
23.4
6.7
9
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
71.9
6.5
7
*
S01FA01
ATC
atropine; ophthalmic
71.9
6.5
7
*
H27.0
ICD-10 Finland
Aphakia
71.9
6.5
7
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
71.9
6.5
7
*
S01EE04
ATC
travoprost; ophthalmic
6.9
6.5
15
23
WX142
NOMESCO Finland
Sub-tenon anesthesy
18.7
6.3
9
5
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
6.3
6
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
6.3
6
*
S01EB01
ATC
pilocarpine; ophthalmic
13.0
6.1
10
8
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 0.913 [0.77, 1.09] | 0.307 |
| Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 903 females with H7_CORNEALOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 1.047 [0.8, 1.37] | 0.737 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 602 males with H7_CORNEALOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.206% |
| 5 | 0.425% | 1.229% |
| 10 | 1.105% | 3.074% |
| 15 | 2.166% | 5.816% |
| 20 | 4.016% | 9.612% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOEDEMA – Other corneal oedema
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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