corneal edema: Hazy, swollen cornea.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
292 |
4. Check minimum number of eventsNone |
292 |
5. Include endpointsNone |
292 |
6. Filter based on genotype QC (FinnGen only) |
282 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Aliud oedema corneae
Similar endpoints
↥List of similar endpoints to
Other corneal oedema
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2050 | 1197 | 844 |
| Only index persons | 1836 | 1082 | 754 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.26 | 75.52 | 70.07 |
| Only index persons | 72.97 | 75.20 | 69.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 282 | 159 | 123 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 72.10 | 72.84 | 71.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 292
- Matched controls
- 2920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.2
ICD-10 Finland
Other corneal oedema
+∞
307.7
284
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.7
117.4
189
344
H16.0
ICD-10 Finland
Corneal ulcer
38.8
100.2
64
21
WX140
NOMESCO Finland
Parabulbar anesthesy
11.6
64.4
76
86
S01EA05
ATC
brimonidine; ophthalmic
21.1
64.3
51
29
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
61.7
57
*
S01ED01
ATC
timolol; ophthalmic
13.6
54.3
55
49
S01ED51
ATC
timolol, combinations; ophthalmic
8.1
53.7
88
148
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
6.6
50.2
215
872
S01EC01
ATC
acetazolamide; systemic
18.0
49.6
42
27
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.8
48.4
97
200
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.1
47.8
114
277
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
47.2
44
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
47.2
44
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
43.9
41
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.9
43.4
216
953
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.5
39.5
216
1000
CG2T4
NOMESCO Finland
Topography assessment of cornea
97.8
39.0
42
5
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
37.3
35
*
H16.9
ICD-10 Finland
Keratitis, unspecified
374.6
33.6
33
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.4
32.1
77
182
H25.1
ICD-10 Finland
Senile nuclear cataract
4.2
31.7
180
812
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
348.3
31.5
31
*
XCK00
NOMESCO Finland
Perimetry
6.3
30.6
58
110
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.2
29.8
73
175
TCG10
NOMESCO Finland
Removal of sutures from cornea
166.5
29.2
30
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
28.8
106
349
114
Kela drug reimbursment
Glaucoma
4.8
27.7
75
195
S01EC04
ATC
brinzolamide; ophthalmic
7.4
26.8
42
65
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
8.9
26.6
35
44
Z3229
NOMESCO Finland
Other healthcare associate professional
5.3
26.2
61
139
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
25.4
24
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
24.3
23
*
S01EE05
ATC
tafluprost; ophthalmic
7.1
23.7
38
60
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
23.2
22
*
CG2S4
NOMESCO Finland
Photography of cornea
90.9
23.0
25
*
H18.6
ICD-10 Finland
Keratoconus
+∞
22.2
21
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
21.6
65
181
WX002
NOMESCO Finland
Sedation and analgesia
3.4
20.2
101
396
H18.8
ICD-10 Finland
Other specified disorders of cornea
213.9
19.8
20
*
S01EA03
ATC
apraclonidine; ophthalmic
25.8
19.0
26
11
S01AD03
ATC
aciclovir; ophthalmic
7.9
19.0
27
37
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
19.0
18
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.3
18.9
41
87
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
23.6
18.5
26
12
H26.4
ICD-10 Finland
After-cataract
3.8
18.2
67
214
S01EE01
ATC
latanoprost; ophthalmic
4.5
18.1
49
125
ZXA05
NOMESCO Finland
Left side
3.0
18.0
121
558
H57.1
ICD-10 Finland
Ocular pain
7.8
16.8
24
33
XCH00
NOMESCO Finland
Eye pressure measurement
5.3
16.6
36
76
H40.0
ICD-10 Finland
Glaucoma suspect
4.1
16.3
50
140
H18.4
ICD-10 Finland
Corneal degeneration
+∞
15.8
15
*
S01EE03
ATC
bimatoprost; ophthalmic
6.9
15.6
25
39
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
30.5
15.4
20
7
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
84.5
14.7
16
*
ZXA00
NOMESCO Finland
Right side
2.7
14.4
123
628
WX142
NOMESCO Finland
Sub-tenon anesthesy
42.2
13.3
16
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
4.4
13.2
35
87
H26.2
ICD-10 Finland
Complicated cataract
23.9
13.1
18
8
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
33.7
12.7
16
5
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
12.6
12
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
17.3
11.8
18
11
S01EX03, ,
ATC
9.9
11.7
23
25
CHD99
NOMESCO Finland
Other filtering operation
24.1
11.7
16
7
ZXA10
NOMESCO Finland
Bilateral
2.6
11.6
88
417
S01EC03
ATC
dorzolamide; ophthalmic
14.4
11.6
19
14
S01EE04
ATC
travoprost; ophthalmic
9.5
11.5
23
26
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
10.6
31
83
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
113.9
10.5
11
*
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
113.9
10.5
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
10.4
47
168
H35.36
ICD-10 Finland
Macular cyst
33.9
10.4
13
*
S01EB01
ATC
pilocarpine; ophthalmic
19.7
10.4
15
8
S01BC03
ATC
diclofenac; ophthalmic
10.6
10.2
19
19
Z3231
NOMESCO Finland
Registered nurse
2.3
10.1
104
563
ZXD20
NOMESCO Finland
Day surgery
2.8
9.9
58
240
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
20.9
9.9
14
7
S01BA04
ATC
prednisolone; ophthalmic
8.3
9.8
21
27
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
5.2
9.5
20
41
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
9.4
9
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
9.4
9
*
S01BA07
ATC
fluorometholone; ophthalmic
11.2
9.4
17
16
CKD60
NOMESCO Finland
Anterior vitrectomy
12.1
8.7
15
13
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
20.8
8.5
12
6
3712A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal oedema
+∞
8.4
8
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
8.4
8
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
8.4
8
*
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
8.4
8
*
3604
FHL
Penetration of the cornea
+∞
8.4
8
*
S01AX11
ATC
[U] ofloxacin
4.1
8.3
23
59
XCH05
NOMESCO Finland
Eye pressure longterm registration
15.0
8.3
13
9
S01ED02
ATC
betaxolol; ophthalmic
12.2
8.2
14
12
CHC05
NOMESCO Finland
Iridotomy
9.3
8.1
16
18
CFW99
NOMESCO Finland
Other operation on conjunctiva
22.8
8.1
11
5
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.6
8.0
27
80
H26.02
ICD-10 Finland
Presenil cataract
6.4
8.0
20
33
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.6
7.9
27
81
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
7.8
7.8
17
23
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
82.1
7.5
8
*
CFD10
NOMESCO Finland
Repair of conjunctiva
82.1
7.5
8
*
S01AA12
ATC
tobramycin; ophthalmic
82.1
7.5
8
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
4.3
7.4
19
46
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.4
7.3
27
85
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
7.3
7
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
7.3
7
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
7.3
7
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
7.3
7
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
7.3
7
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
+∞
7.3
7
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
7.3
7
*
H27.1
ICD-10 Finland
Dislocation of lens
30.8
7.2
9
*
S01FA01
ATC
atropine; ophthalmic
20.6
7.2
10
5
H27.0
ICD-10 Finland
Aphakia
20.6
7.2
10
5
S01BA01
ATC
dexamethasone; ophthalmic
4.3
6.9
18
44
S01BC05
ATC
ketorolac; ophthalmic
3.4
6.7
25
79
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
5.9
6.6
17
30
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.6
6.6
22
65
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
6.3
6
*
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
6.3
6
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
6.3
6
*
H16.8
ICD-10 Finland
Other keratitis
+∞
6.3
6
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
27.3
6.3
8
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
3.8
6.1
19
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
221
1727
2.15
7.31
3.9
4.0
14.94
15.00
pmol/l
0.13
201
1529
153
1054
1.95
7.23
2.2
2.0
91.30
95.41
pmol/l
0.45
74
530
254
2114
2.55
7.01
5.0
4.8
2.19
2.00
mu/l
1.74
231
1878
277
2440
3.63
6.28
12.9
10.7
23.38
24.69
u/l
1.02
260
2341
174
1289
1.87
6.22
7.8
6.1
1.21
1.22
mmol/l
0.93
144
1092
162
1177
1.85
6.13
6.9
5.4
1.20
1.22
mmol/l
1.35
141
1073
274
2412
3.21
5.94
25.1
18.6
139.34
139.60
mmol/l
0.69
268
2346
274
2417
3.17
5.81
25.9
18.6
3.98
3.99
mmol/l
0.36
269
2346
114
758
1.83
5.64
4.0
3.8
9.22
9.14
mg/mmol
0.01
74
476
57
301
2.11
5.53
2.0
1.8
—
—
—
0
0
12
17
7.31
5.49
1.2
1.5
—
—
—
0
0
187
1452
1.80
5.38
5.5
4.5
7.21
6.82
mmol/l
1.25
176
1366
56
299
2.08
5.26
2.0
1.8
—
—
—
0
0
259
2260
2.29
4.97
4.9
4.6
4.48
4.56
mmol/l
0.58
236
2054
95
617
1.80
4.96
2.6
2.1
3.18
3.24
mg/l
0.07
84
528
154
1154
1.71
4.81
4.9
4.3
0.00
0.00
estimate
-0.00
25
231
71
427
1.88
4.72
2.0
1.8
—
—
—
0
0
258
2259
2.22
4.72
5.6
4.9
6.16
6.06
mmol/l
0.52
238
2034
272
2438
2.69
4.67
24.0
18.8
85.26
79.43
umol/l
0.99
272
2438
278
2520
3.15
4.65
31.3
23.0
244.83
243.25
e9/l
0.16
269
2448
278
2521
3.14
4.62
31.6
23.0
39.07
39.64
%
0.66
246
2357
278
2521
3.14
4.62
31.3
23.0
4.36
4.42
e12/l
1.36
269
2439
155
1172
1.69
4.61
5.0
4.3
0.00
0.00
estimate
-0.00
22
205
278
2522
3.13
4.60
31.5
23.1
131.06
133.40
g/l
1.77
273
2477
163
1255
1.68
4.48
19.3
15.1
1.37
1.31
inr
0.29
39
352
153
1162
1.67
4.41
6.0
5.7
0.00
0.00
estimate
-0.00
21
208
146
1103
1.65
4.24
5.4
4.3
34.66
35.03
g/l
0.35
133
1033
260
2313
2.13
4.08
5.7
5.2
2.54
2.66
mmol/l
1.13
234
2087
135
1007
1.63
4.08
2.5
2.2
80.65
77.72
nmol/l
0.56
121
881
259
2302
2.11
4.05
21.2
15.6
24.36
24.69
mg/l
0.06
215
1850
165
1298
1.62
3.98
6.9
6.0
10.11
11.30
umol/l
1.19
156
1222
8
11
7.44
3.88
1.0
1.1
—
—
—
0
0
80
527
1.71
3.86
1.9
1.7
1351.96
1210.42
nmol/l
0.58
57
397
253
2240
1.97
3.85
4.9
4.6
1.47
1.48
mmol/l
0.14
230
2021
79
520
1.71
3.82
5.9
5.1
1.01
1.02
kg/l
0.58
14
78
207
1736
1.66
3.75
4.6
4.2
15.67
13.44
mm/h
1.07
189
1585
55
327
1.84
3.75
6.9
4.7
1.05
1.03
mmol/l
0.20
49
291
217
1846
1.68
3.68
8.4
7.4
81.67
79.81
u/l
0.14
205
1722
47
268
1.90
3.64
2.2
2.8
5.89
8.23
umol/l
0.73
35
231
144
1121
1.56
3.46
2.7
2.5
—
—
—
0
0
106
769
1.59
3.46
3.3
2.5
58.00
56.67
u/l
0.18
94
712
77
517
1.66
3.43
6.0
3.7
388.71
185.33
ng/l
0.29
66
428
52
313
1.80
3.40
5.9
5.9
0.94
1.30
mmol/l
0.36
38
258
126
956
1.56
3.37
3.7
2.7
151.01
136.75
ug/l
0.20
117
863
51
308
1.79
3.30
9.1
8.7
—
—
—
0
0
64
413
1.70
3.29
3.8
2.9
0.82
0.81
mmol/l
0.26
57
382
244
2165
1.77
3.29
4.4
4.1
1.32
1.27
mmol/l
0.57
221
1935
67
441
1.67
3.20
3.4
2.8
1.56
1.33
e6/l
0.23
45
250
168
1378
1.52
3.03
9.9
8.6
4.12
4.19
e9/l
0.16
147
1203
141
1119
1.50
2.96
8.1
5.4
26.10
26.78
%
0.31
129
1045
15
58
2.67
2.92
2.2
1.5
—
—
—
0
0
243
2178
1.69
2.85
7.4
6.2
42.51
40.63
mmol/mol
1.73
222
1999
139
1106
1.49
2.85
7.7
5.2
58.12
58.08
%
0.01
124
1036
113
867
1.49
2.74
3.6
3.2
2.35
2.36
mmol/l
0.04
96
754
97
722
1.51
2.72
3.8
3.2
0.57
0.61
e6/l
0.04
78
541
6
10
6.10
2.71
1.2
1.2
—
—
—
0
0
243
2191
1.65
2.63
19.0
15.0
72.93
74.98
ml/min/173m2
0.66
198
1805
87
642
1.51
2.52
5.8
4.6
0.00
0.00
estimate
-0.00
23
203
97
733
1.48
2.50
3.2
3.3
28.01
31.17
u/l
0.98
91
701
10
32
3.20
2.46
1.0
1.3
—
—
—
0
0
11
38
2.97
2.44
2.9
3.4
56.09
63.00
%
0.53
11
38
100
774
1.44
2.24
2.3
2.0
118.75
213.01
u/l
2.72
93
728
114
910
1.41
2.14
5.2
4.6
—
—
—
0
0
127
1036
1.40
2.10
4.6
4.0
48.71
40.15
ng/l
0.20
90
787
5
10
5.07
2.08
1.2
1.0
—
—
—
0
0
84
639
1.44
2.05
1.7
1.6
24.95
21.23
nmol/l
0.87
71
537
31
188
1.73
2.00
1.8
1.5
—
—
—
0
0
75
561
1.45
1.99
2.0
1.8
100000410.80
450.79
pmol/l
0.49
64
448
51
352
1.54
1.99
3.4
2.3
21.09
21.25
%
0.02
40
298
115
932
1.39
1.94
4.2
3.2
—
—
—
0
0
15
72
2.14
1.90
1.3
1.2
—
—
—
0
0
77
584
1.43
1.90
2.2
2.1
—
—
—
0
0
15
73
2.11
1.84
1.3
1.2
—
—
—
0
0
7
23
3.09
1.81
1.4
3.9
—
1265.40
—
0
5
32
202
1.66
1.80
3.4
2.9
64.46
57.30
ml/min/173m2
0.47
13
83
25
152
1.71
1.63
1.4
1.4
—
—
—
0
0
26
160
1.69
1.62
1.8
1.7
—
—
—
0
0
66
502
1.41
1.59
1.9
1.7
1.33
1.29
mg/l
0.06
50
401
34
226
1.57
1.58
2.7
2.5
30.10
29.10
u/l
0.15
29
190
56
418
1.42
1.50
3.8
3.0
1.87
3.39
e6/l
1.10
37
227
26
167
1.61
1.40
8.3
6.5
1.13
1.49
%
1.40
26
167
17
97
1.80
1.38
1.5
1.3
—
—
—
0
0
5
17
2.97
1.36
2.0
1.3
—
—
—
0
0
11
54
2.08
1.34
1.5
1.6
—
—
—
0
0
14
77
1.86
1.27
1.3
1.2
—
—
—
0
0
101
850
1.29
1.23
3.4
3.1
2772.59
1363.86
ng/l
1.32
84
722
6
26
2.33
1.19
1.5
1.1
—
—
—
0
0
23
150
1.58
1.18
3.4
3.4
0.60
2.05
mmol/l
0.61
17
112
31
217
1.48
1.17
2.4
2.5
4.31
4.23
kpa
0.09
31
207
5
20
2.53
1.15
1.2
1.8
—
—
—
0
0
138
1217
1.25
1.12
2.4
2.6
—
—
—
0
0
5
21
2.40
1.09
1.2
1.8
—
—
—
0
0
35
256
1.42
1.07
3.1
3.2
5.65
5.78
kpa
0.38
35
246
45
344
1.36
1.07
7.0
5.5
103.89
103.94
mmol/l
0.02
45
344
39
291
1.39
1.07
1.5
1.4
—
—
—
0
0
7
33
2.15
1.06
1.6
1.1
—
—
—
0
0
30
214
1.45
1.05
3.2
3.5
111.21
81.04
ng/l
0.80
23
188
6
120
0.49
0.95
6.0
3.2
20.20
1329.78
u/ml
—
6
103
9
51
1.79
0.95
1.4
2.3
—
—
—
0
0
7
37
1.91
0.94
1.3
1.4
—
—
—
0
0
75
629
1.26
0.92
1.6
1.6
1.33
1.29
mmol/l
0.18
67
519
30
220
1.41
0.92
3.8
3.1
66.25
66.81
g/l
0.12
24
198
38
291
1.35
0.91
1.3
1.5
—
—
—
0
0
10
57
1.78
0.84
1.1
1.5
—
—
—
0
0
154
1404
1.20
0.84
3.1
3.1
58.90
53.49
u/l
0.31
136
1298
16
106
1.54
0.80
1.0
1.0
—
—
—
0
0
10
58
1.75
0.80
1.1
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.7
—
—
—
0
0
5
25
2.02
0.73
1.0
1.6
—
—
—
0
0
5
26
1.94
0.71
1.2
1.6
—
—
—
0
0
5
26
1.94
0.71
1.2
1.6
—
—
—
0
0
7
41
1.72
0.70
1.1
1.6
—
—
—
0
0
7
42
1.68
0.69
1.6
2.2
—
—
—
0
0
17
120
1.44
0.66
2.8
2.9
4.89
4.42
pmol/l
0.64
17
106
5
29
1.74
0.64
1.0
1.2
—
—
—
0
0
71
618
1.20
0.62
3.5
2.7
368.94
6807.96
umol/l
2.87
62
523
5
30
1.68
0.61
1.8
1.0
—
—
—
0
0
56
477
1.22
0.61
1.3
1.2
5.23
0.98
u/ml
—
10
118
19
140
1.38
0.60
1.5
2.4
1.13
1.26
%
0.23
19
140
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
8
53
1.52
0.59
1.4
1.4
—
—
—
0
0
8
53
1.52
0.59
1.4
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
94.40
—
0
5
6
35
1.73
0.58
1.0
1.6
—
—
—
0
0
6
35
1.73
0.58
1.2
1.7
—
—
—
0
0
6
35
1.73
0.58
1.2
1.7
—
—
—
0
0
12
81
1.50
0.58
3.0
3.2
—
—
—
0
0
6
36
1.68
0.57
1.8
2.5
108.00
106.06
mmol/l
—
6
36
6
36
1.68
0.57
1.2
1.0
—
—
—
0
0
6
36
1.68
0.57
3.3
1.3
—
—
—
0
0
31
249
1.27
0.56
3.5
2.4
3.81
6.85
ug/l
1.39
24
222
6
37
1.63
0.56
1.0
1.6
—
—
—
0
0
18
135
1.36
0.52
1.6
2.4
0.63
0.68
%
0.36
18
135
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
75
1.48
0.51
4.8
1.9
0.20
0.37
u/ml
—
6
43
33
272
1.24
0.50
3.1
3.6
—
—
—
0
0
25
200
1.27
0.48
1.9
1.8
1.51
1.50
%
0.00
20
170
7
47
1.50
0.48
1.3
1.1
—
—
—
0
0
8
117
0.67
0.47
2.1
1.8
—
—
—
0
0
58
515
1.16
0.41
3.6
2.9
2.46
2.47
mmol/l
0.30
52
448
36
307
1.20
0.41
3.1
4.1
3.59
43.10
ug/l
0.94
30
265
8
60
1.34
0.40
1.3
1.4
—
—
—
0
0
5
34
1.48
0.40
1.2
1.8
—
—
—
0
0
5
34
1.48
0.40
1.6
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
7
105
0.66
0.40
2.0
1.7
—
—
—
0
0
13
99
1.33
0.36
2.7
1.9
2.77
3.01
g/l
—
8
90
6
42
1.44
0.35
1.0
1.6
—
—
—
0
0
6
44
1.37
0.34
1.2
1.1
2.00
17.64
e6/l
—
6
36
6
44
1.37
0.34
1.2
1.6
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
1.00
192.92
e6/l
—
6
36
11
82
1.35
0.34
3.2
4.5
—
2.85
—
0
9
16
127
1.27
0.34
3.6
3.3
23.90
24.28
mmol/l
0.22
16
122
82
756
1.12
0.34
5.0
5.0
1.62
2.73
ug/l
1.46
72
666
7
53
1.33
0.31
1.0
1.4
—
—
—
0
0
12
94
1.29
0.28
3.7
4.1
3.90
3.89
mmol/l
0.02
12
94
8
63
1.28
0.28
2.4
1.3
—
—
—
0
0
5
38
1.32
0.23
1.2
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
27.76
—
0
10
0
12
0.00
0.21
0.0
1.0
—
1.00
—
0
6
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
65
610
1.08
0.20
4.3
4.3
20.77
21.22
%
0.09
30
287
13
109
1.20
0.19
2.7
1.9
—
—
—
0
0
7
60
1.17
0.18
1.1
1.7
—
—
—
0
0
5
70
0.71
0.17
1.6
1.5
—
—
—
0
0
9
78
1.16
0.15
1.4
1.6
—
180.00
—
0
5
10
85
1.18
0.12
3.0
1.9
39.36
37.84
g/l
—
5
76
11
126
0.87
0.11
1.5
1.7
—
—
—
0
0
5
44
1.14
0.10
1.4
1.1
—
—
—
0
0
43
433
0.99
0.00
3.1
3.0
0.73
0.86
ug/l
0.35
33
279
31
307
1.01
0.00
4.6
4.6
30.54
32.08
%
0.26
13
199
39
395
0.99
0.00
1.3
1.2
23.69
40.98
iu/ml
—
9
129
10
104
0.96
0.00
1.7
1.8
—
—
—
0
0
35
355
0.98
0.00
1.2
1.3
1.82
12.08
u/ml
1.62
13
127
5
55
0.91
-0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.9
—
210.38
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.88
—
0
6
5
49
1.02
-0.00
1.0
1.2
—
43.83
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
95
0.95
-0.00
1.8
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
32.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 0.913 [0.77, 1.09] | 0.307 |
| Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 903 females with H7_CORNEALOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 1.047 [0.8, 1.37] | 0.737 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 602 males with H7_CORNEALOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.206% |
| 5 | 0.425% | 1.229% |
| 10 | 1.105% | 3.074% |
| 15 | 2.166% | 5.816% |
| 20 | 4.016% | 9.612% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOEDEMA – Other corneal oedema
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data