Eccrine sweat disorders

L12_ECCRINESWEAT

sweat gland disease: disorders or sweat glands

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L74 Cause of death: ICD-10 — L74 2 out of 7 registries used, show all original rules.	74
4. Check minimum number of events None	74
5. Include endpoints L12_MILIARUBRA L12_MILIACRYSTAL L12_MILIAPROFUND L12_MILIANAS L12_ANHIDROSIS L12_ECCRINENAS	89
6. Filter based on genotype QC (FinnGen only)	89

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L60-L75
Name in latin: Morbositates glandularum sudoriferarum eccrinarum

NAME	L12_ECCRINESWEAT
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_MILIARUBRA\|L12_MILIACRYSTAL\|L12_MILIAPROFUND\|L12_MILIANAS\|L12_ANHIDROSIS\|L12_ECCRINENAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L74
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L74
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Eccrine sweat disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	675	388	284
Only index persons	590	348	242
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	39.54	44.02	33.11
Only index persons	40.08	44.15	34.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	89	54	35
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	46.10	50.14	39.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
808

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L74.0

ICD-10 Finland

Miliaria rubra

+∞

17.3

L74.9

ICD-10 Finland

Eccrine sweat disorder, unspecified

196.4

16.1

L74.8

ICD-10 Finland

Other eccrine sweat disorders

+∞

11.7

L74.1

ICD-10 Finland

Miliaria crystallina

+∞

8.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.4

7.6

L74.3

ICD-10 Finland

Miliaria, unspecified

+∞

7.4

L74.4

ICD-10 Finland

Anhidrosis

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

220

2.38

3.79

2.4

2.3

58.1

56.1

u/l

0.17

203

(40768443) Skin Pathology biopsy report

3.29

2.62

1.6

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

127

2.22

2.58

4.3

2.7

81.6

156.6

ng/l

0.36

(3013826) Glucose [Moles/volume] in Serum or Plasma

432

1.89

2.13

3.7

4.4

6.8

6.6

mmol/l

0.21

400

(42870588) Differential panel, method unspecified - Blood

245

1.87

2.12

5.4

5.6

—

(3009343) pH of Capillary blood

2.71

2.10

3.3

3.5

—

7.5

—

(3019198) Lymphocytes [#/volume] in Blood

366

1.84

2.07

6.0

6.4

1.9

1.8

e9/l

0.63

334

(3048689) Calprotectin [Mass/mass] in Stool

2.17

2.03

3.1

2.6

590.0

103.2

ug/g

0.96

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.53

2.01

1.3

1.5

—

(3001604) Monocytes [#/volume] in Blood

360

1.80

1.97

6.1

6.3

0.6

e9/l

0.54

318

(3006315) Basophils [#/volume] in Blood

360

1.80

1.97

6.1

6.3

0.0

e9/l

0.21

318

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

1.96

0.0

1.5

—

1.0

—

(3022313) Gas panel - Capillary blood

2.83

1.93

3.3

3.7

—

(3013115) Eosinophils [#/volume] in Blood

372

1.79

1.91

6.1

6.4

0.2

e9/l

1.06

334

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

171

1.83

1.73

1.3

1.2

9.4

2.3

u/ml

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

738

2.41

1.63

16.8

12.9

19.3

24.7

mg/l

0.97

559

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

547

1.80

1.61

3.8

4.1

14.9

14.7

pmol/l

0.23

489

(3026008) Bacteria identified in Urine by Culture

209

1.74

1.60

3.0

2.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

194

1.73

1.53

2.3

3.3

1176.6

1233.8

ng/l

0.03

169

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

3.25

1.46

2.2

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.53

1.42

1.6

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

115

1.83

1.39

1.6

1.4

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

245

1.63

1.35

2.7

3.0

30.5

32.9

u/l

0.24

229

(3019060) Gas panel - Arterial blood

2.16

1.31

1.7

4.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

672

1.90

1.30

4.6

4.7

1.9

1.8

mu/l

0.07

602

(3031040) Bacteria [#/volume] in Urine by Automated count

471

1.58

1.24

6.4

4.1

—

328.0

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.89

1.21

3.1

4.4

28.1

33.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.89

1.21

1.5

1.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.40

1.21

1.7

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

423

1.55

1.19

9.7

9.9

4.2

4.1

e9/l

0.08

371

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

326

1.55

1.19

3.6

—

(3009508) Creatinine [Moles/volume] in Urine

207

1.59

1.17

3.5

2.9

6.2

8.1

mmol/l

1.07

176

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.59

1.16

1.4

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

105

1.77

1.16

2.2

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.04

1.12

1.9

2.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.06

1.07

2.8

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.15

1.05

1.9

2.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

258

1.51

1.04

4.6

2.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

196

1.54

1.01

4.1

3.7

12.7

7.4

mg/mmol

0.23

118

(3019225) pH of Specimen

1.88

0.99

6.6

4.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.75

0.98

2.5

2.0

2.6

2.4

g/l

0.33

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

280

1.48

0.97

3.1

3.8

22.3

43.1

ng/l

0.71

190

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

339

1.45

0.93

6.7

6.6

1.2

mmol/l

0.25

277

(3003327) Ova and parasites identified in Stool by Light microscopy

2.14

0.91

1.5

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.73

0.90

1.9

2.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.77

0.90

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

166

1.52

0.87

1.7

2.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.00

0.86

1.2

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.69

0.79

1.2

1.8

—

(3020891) Body temperature

1.82

0.78

1.8

3.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.24

0.77

1.2

1.4

—

(3003396) Base excess in Arterial blood by calculation

1.64

0.77

1.6

7.0

0.3

0.8

mmol/l

—

(3032080) INR in Blood by Coagulation assay

291

1.40

0.76

4.7

6.2

1.0

1.2

inr

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

254

1.41

0.75

1.7

1.8

90.6

98.2

pmol/l

0.40

114

(3022948) Iron [Moles/volume] in Serum or Plasma

1.60

0.75

2.5

2.0

11.4

13.6

umol/l

0.44

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.06

0.74

2.4

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.77

0.72

1.0

—

(3049717) Cytology report of Urine Cyto stain

1.98

0.72

2.4

2.5

—

(3023520) Reticulocytes [#/volume] in Blood

1.72

0.70

4.3

2.9

90.7

70.0

e9/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

704

1.54

0.69

13.3

12.3

85.3

84.3

ml/min/173m2

0.12

572

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.65

0.69

2.2

1.6

—

(4034850)

1.83

0.67

15.0

6.0

—

(3044640) Blood type and Crossmatch panel - Blood

214

1.38

0.63

1.9

2.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.61

0.0

3.6

—

183.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.61

0.0

1.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.61

0.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

188

1.38

0.60

3.3

3.0

58.6

55.6

mg/l

0.02

113

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.52

0.59

2.5

2.4

—

(40761535) Cells panel - Urine sediment

1.53

0.59

6.8

3.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.76

0.59

2.5

2.2

—

(3002256) Pathology report gross observation

1.54

0.58

1.4

1.2

—

(3000494) Fungus identified in Specimen by Culture

1.50

0.57

1.3

1.4

—

(3023368) Bacteria identified in Blood by Culture

181

1.37

0.55

4.3

4.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.58

0.55

4.2

4.5

2.7

67.2

ug/l

—

(3012544) pH of Venous blood

1.45

0.53

3.1

3.7

—

(40768804) Tissue Pathology biopsy report

286

1.31

0.53

2.9

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.48

0.50

4.8

3.3

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.57

0.49

1.3

2.6

14.0

22.9

u/ml

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

705

1.41

0.49

5.1

4.3

5.9

mmol/l

0.25

642

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

150

1.34

0.45

1.8

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.54

0.42

1.6

1.1

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

6.2

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

1.9

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.7

—

368.6

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.3

—

3.6

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.7

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.50

0.41

3.4

3.5

30.3

25.0

mmol/l

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.43

0.40

1.2

3.1

0.2

g/l

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.40

0.0

1.3

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.40

0.0

2.7

—

125.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

221

0.77

0.39

2.8

3.3

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.39

0.0

1.5

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.39

0.0

1.7

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.39

0.0

1.4

—

184.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

135

1.32

0.39

1.4

1.3

11.4

37.7

iu/ml

—

(3022145) Colonoscopy Study observation

1.41

0.38

1.5

1.3

—

(40768797) Stomach Pathology biopsy report

1.37

0.38

1.4

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.50

0.37

1.0

2.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.50

0.37

1.7

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

757

1.39

0.37

5.0

4.7

2.8

mmol/l

0.02

698

(3042936) Bacteria identified in Isolate by Culture

100

1.35

0.36

2.2

2.0

—

(1761868) Lipid panel - Serum or Plasma

311

0.81

0.35

3.1

2.8

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.38

0.32

2.3

3.3

3.6

4.1

kpa

—

(3009542) Hematocrit [Volume Fraction] of Blood

687

1.25

0.30

14.0

13.0

40.7

40.4

0.10

520

(36660697) Celiac disease serology panel - Serum

1.34

0.29

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

503

1.19

0.28

6.3

4.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.27

0.28

3.3

3.6

7.0

5.9

kpa

—

(3018095) Leukocytes [#/volume] in Urine

257

1.19

0.27

4.1

3.5

1801.3

30.5

e6/l

0.48

171

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.37

0.24

2.0

7.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

745

1.25

0.23

4.8

4.2

1.3

1.5

mmol/l

2.87

688

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

101

0.77

0.22

1.4

1.8

1.7

1.5

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.20

0.22

1.2

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.21

0.0

1.2

—

91.5

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.5

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

3.4

—

(4306422)

0.00

0.21

0.0

1.2

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.9

—

0.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

726

1.21

0.20

4.3

3.8

1.4

1.3

mmol/l

0.32

665

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

747

1.23

0.20

5.1

4.2

4.5

4.7

mmol/l

0.88

699

(3045424) Erythrocytes [Presence] in Urine

0.00

0.20

0.0

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

(4268621)

0.00

0.20

0.0

1.9

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

1.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.20

0.0

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

159

1.17

0.16

1.3

1.4

3.1

2.7

g/l

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.76

0.16

6.3

1.7

355.3

367.3

nmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.74

0.16

1.8

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

218

1.14

0.16

3.5

2.8

13.1

329.8

e6/l

0.50

157

(3021960) Folate [Moles/volume] in Serum or Plasma

151

1.16

0.14

1.4

1.5

24.2

20.4

nmol/l

0.24

120

(36304419) Bacteria [Presence] in Urine

200

1.13

0.14

3.5

2.5

—

(40758558) Short blood count panel - Blood

189

0.88

0.13

7.9

7.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

489

1.10

0.12

3.8

3.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.18

0.11

1.5

1.8

—

(3029937) Albumin [Presence] in Urine by Test strip

213

1.11

0.10

5.7

3.9

0.0

estimate

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

673

1.11

0.10

6.0

5.4

38.5

39.5

mmol/mol

0.75

629

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.17

0.10

7.0

6.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.07

0.09

1.2

1.7

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.12

0.09

1.3

3.4

70.9

67.7

g/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.82

0.08

3.2

2.6

27.8

30.0

u/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.82

0.08

1.2

1.5

—

(3000991) Gas panel - Venous blood

0.80

0.08

4.2

7.1

—

(40761536) Microorganisms panel - Urine sediment

1.10

0.08

4.4

3.4

—

(3044889) 12 lead EKG panel

516

0.93

0.08

4.2

3.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

137

1.11

0.08

2.2

1.9

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

187

1.09

0.07

3.4

4.2

0.9

2.0

ug/l

6.14

168

(3011397) Hemoglobin [Presence] in Urine by Test strip

169

0.94

0.03

7.2

3.9

—

(3030467) Casts [#/volume] in Urine by Automated count

201

1.06

0.03

3.7

2.6

0.1

0.3

e6/l

1.32

138

(40760892) CBC W Ordered Manual Differential panel - Blood

183

1.05

0.01

7.0

4.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

297

0.97

0.01

5.0

3.9

—

(3013512) EKG study

204

1.04

0.00

4.0

3.6

—

(3035350) Ketones [Presence] in Urine by Test strip

376

0.97

0.00

4.6

3.8

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

386

0.97

0.00

4.6

3.9

0.0

estimate

—

(40761511) CBC panel - Blood by Automated count

778

1.02

0.00

15.6

12.0

—

(3021589) Normoblasts [#/volume] in Blood

341

1.00

0.00

7.7

10.6

0.0

e9/l

0.48

279

(3015736) pH of Urine

287

1.02

0.00

5.5

3.6

—

(3003694) ABO and Rh group [Type] in Blood

195

0.97

0.00

1.5

1.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

115

1.05

0.00

2.3

3.1

2.4

mmol/l

0.14

103

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

114

0.96

0.00

1.5

1.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

382

0.99

0.00

5.4

5.3

0.0

estimate

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.98

0.00

1.8

1.3

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.90

0.00

1.4

1.8

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.0

3.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.4

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

44.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.1

—

6.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.6

—

11.6

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.9

—

(4035726)

0.84

0.00

1.6

1.3

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.0

—

336.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.6

—

1.8

—

(3002385) Erythrocyte distribution width [Ratio]

620

1.00

0.00

15.0

16.2

13.9

13.5

0.72

609

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

7.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

13.6

—

0.7

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.01

0.00

1.1

1.7

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

7.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

18.1

—

1408.5

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.8

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(21494755) Public health laboratory ask at order entry panel

0.91

0.00

1.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

12.8

—

754.3

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

315.2

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.6

—

2.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.7

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

5.5

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

308.6

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.4

—

147.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.2

—

(4281824)

0.00

0.0

1.1

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.2

—

(3000492) Spirometry study

0.93

0.00

2.3

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ECCRINESWEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ECCRINESWEAT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_ECCRINESWEAT – Eccrine sweat disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Eccrine sweat disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints