No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
147 |
4. Check minimum number of eventsNone |
147 |
5. Include endpointsNone |
147 |
6. Filter based on genotype QC (FinnGen only) |
140 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[0-4]
- Name in latin
- Aliae malformationes congenitae renis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- All chronic kidney diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1596 | 808 | 785 |
| Only index persons | 1208 | 636 | 572 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 9.78 | 12.50 | 6.90 |
| Only index persons | 20.45 | 23.76 | 16.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 140 | 88 | 52 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 43.52 | 43.54 | 43.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 147
- Matched controls
- 1469
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q63.1
ICD-10 Finland
Lobulated, fused and horseshoe kidney
+∞
63.1
56
*
Q63.2
ICD-10 Finland
Ectopic kidney
+∞
44.0
40
*
Q63.9
ICD-10 Finland
Congenital malformation of kidney, unspecified
+∞
26.9
25
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.8
26.4
32
37
UKC02
NOMESCO Finland
Cystoscopy
7.1
23.5
43
81
Q63.88
ICD-10 Finland
Other specified congenital malformations of kidney
+∞
20.3
19
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
25.4
11.8
16
7
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
11.6
11
*
Q63.0
ICD-10 Finland
Accessory kidney
+∞
10.5
10
*
N18.8
ICD-10 Finland
Other chronic renal failure
20.7
10.5
15
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
14.6
10.5
17
13
KA1FN
NOMESCO Finland
Isotope renography
106.5
9.5
10
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
9.5
9
*
N18.0
ICD-10 Finland
End-stage renal disease
95.2
8.5
9
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
35.5
8.2
10
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
23.6
8.1
11
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.1
8.0
13
10
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.4
7.9
18
27
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
47.5
7.8
9
*
TK800
NOMESCO Finland
Hemodialysis
14.4
7.5
12
9
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.6
7.5
28
91
A11CC03
ATC
alfacalcidol; systemic
11.7
7.5
13
12
Q63.81
ICD-10 Finland
Congenital diverticulum in renal cup
+∞
7.3
7
*
Z94.0
ICD-10 Finland
Kidney transplant status
21.3
7.2
10
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.3
7.2
10
5
A12AA04
ATC
calcium carbonate; oral
11.7
6.9
12
11
KA1AE
NOMESCO Finland
Kidney ultrasound examination
10.8
6.7
12
12
J01EA01
ATC
trimethoprim; systemic
2.6
6.5
47
222
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
72.8
6.5
7
*
Q62.5
ICD-10 Finland
Duplication of ureter
+∞
6.3
6
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
13.3
6.2
10
8
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
6.0
44
208
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
119
4.54
14.06
19.7
12.8
10.29
7.24
mmol/l
1.91
42
113
27
70
4.50
9.92
8.8
17.4
1.44
1.23
mg/l
0.60
27
65
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
33
5.68
6.24
3.2
18.1
0.24
0.36
u/ml
—
5
21
90
584
2.39
6.12
16.4
9.6
1.21
1.22
mmol/l
0.92
83
515
73
437
2.33
5.93
9.0
3.6
—
—
—
0
0
61
360
2.19
4.92
8.7
3.4
0.24
0.41
e6/l
0.50
53
265
21
78
2.97
4.47
3.6
3.1
66.38
67.90
ml/min/173m2
0.07
13
31
41
215
2.26
4.34
6.8
3.4
1.51
2.75
e6/l
0.69
29
119
29
130
2.53
4.34
9.4
8.6
104.69
103.65
mmol/l
0.60
29
130
48
278
2.08
3.92
7.6
3.6
23.54
15.71
mg/mmol
0.37
32
162
23
97
2.62
3.88
3.2
3.1
—
—
—
0
0
58
362
1.99
3.85
4.4
3.9
2.34
2.35
mmol/l
0.39
52
325
16
56
3.08
3.76
6.5
7.7
0.89
0.68
%
1.91
16
56
34
177
2.20
3.62
7.5
2.7
12.56
13.70
umol/l
0.54
34
168
83
598
1.89
3.50
6.2
3.8
0.00
0.00
estimate
-0.00
20
90
82
589
1.88
3.48
6.1
3.8
0.00
0.00
estimate
-0.00
21
100
81
589
1.83
3.22
8.3
5.2
0.00
0.00
estimate
-0.00
19
96
29
149
2.18
3.17
14.5
14.2
24.05
24.97
mmol/l
0.86
29
149
39
226
1.99
3.11
5.7
3.2
1.00
0.77
e6/l
0.20
26
127
15
59
2.72
2.88
10.9
10.1
94.35
93.95
%
0.11
15
59
5
6
8.56
2.77
1.6
1.0
8.86
11.00
umol/l
—
5
6
66
470
1.73
2.68
8.1
10.0
1.04
1.20
inr
2.96
18
129
11
36
3.22
2.62
1.4
1.6
—
—
—
0
0
44
281
1.81
2.58
2.3
2.7
—
—
—
0
0
73
541
1.69
2.52
2.8
2.7
—
—
—
0
0
6
12
5.16
2.42
1.0
1.5
—
—
—
0
0
18
87
2.22
2.28
2.8
1.6
—
—
—
0
0
21
110
2.06
2.19
8.7
7.5
5.02
5.25
kpa
0.62
21
103
21
110
2.06
2.19
8.7
7.5
0.62
1.35
mmol/l
0.27
16
89
24
134
1.94
2.11
13.4
12.0
1.12
1.34
mmol/l
0.17
12
104
37
241
1.71
1.99
4.4
4.3
351.19
4832.40
umol/l
1.07
32
215
58
430
1.57
1.87
6.4
3.8
—
—
—
0
0
14
68
2.17
1.76
1.9
1.2
—
—
—
0
0
42
295
1.59
1.68
7.6
4.1
0.00
0.01
estimate
0.49
20
89
6
20
3.08
1.59
4.7
3.3
53.17
58.00
%
—
6
20
115
1019
1.59
1.50
21.6
11.0
77.52
88.18
ml/min/173m2
3.45
102
810
0
40
0.00
1.35
0.0
1.5
—
—
—
0
0
17
99
1.81
1.34
1.5
1.4
151.78
369.83
u/ml
0.43
17
90
103
903
1.47
1.30
4.0
3.9
14.69
14.53
pmol/l
0.30
96
827
11
56
2.04
1.25
9.8
6.7
23.35
25.25
mmol/l
0.72
11
50
120
1092
1.53
1.19
4.6
4.4
1.71
1.85
mu/l
0.82
110
996
0
33
0.00
1.18
0.0
1.4
—
—
—
0
0
123
1127
1.56
1.16
24.9
17.4
14.47
14.51
%
0.02
123
1111
0
36
0.00
1.15
0.0
1.6
—
—
—
0
0
48
375
1.41
1.12
2.5
1.8
90.86
98.31
pmol/l
0.43
24
192
7
33
2.17
1.07
1.1
2.9
—
—
—
0
0
5
22
2.31
1.04
1.2
1.9
—
—
—
0
0
85
737
1.36
1.03
8.3
12.1
3.68
3.88
e9/l
0.43
77
634
45
356
1.38
0.97
3.2
3.3
27.93
31.00
ng/l
0.13
32
219
35
265
1.42
0.96
2.0
3.3
1.27
0.84
mg/l
0.74
28
211
8
42
1.95
0.90
3.0
1.2
—
—
—
0
0
10
57
1.81
0.86
2.4
1.5
—
—
—
0
0
11
65
1.75
0.85
2.3
3.8
4.35
4.71
pmol/l
0.55
11
57
8
46
1.78
0.84
2.8
2.5
—
—
—
0
0
8
47
1.74
0.82
1.5
1.1
—
—
—
0
0
8
47
1.74
0.82
1.5
1.6
—
—
—
0
0
6
33
1.85
0.80
1.0
1.2
—
—
—
0
0
6
33
1.85
0.80
4.2
2.1
—
—
—
0
0
15
99
1.57
0.79
2.3
4.6
4.53
5.54
ug/l
—
9
80
7
38
1.88
0.74
1.1
1.2
—
15.20
—
0
7
5
25
2.03
0.73
1.2
1.6
—
—
—
0
0
25
188
1.40
0.72
2.1
2.0
—
—
—
0
0
5
26
1.95
0.71
1.2
1.5
—
—
—
0
0
7
41
1.74
0.71
1.9
1.2
—
—
—
0
0
7
41
1.74
0.71
2.0
1.3
—
—
—
0
0
43
354
1.30
0.70
1.4
1.5
6.46
1.42
u/ml
0.42
14
71
5
95
0.51
0.69
1.8
1.9
—
—
—
0
0
129
1225
1.43
0.68
24.7
13.3
26.88
21.98
mg/l
0.71
107
921
5
28
1.81
0.66
1.2
1.9
—
—
—
0
0
5
30
1.69
0.62
1.0
1.1
—
—
—
0
0
7
111
0.61
0.61
2.0
2.1
—
—
—
0
0
14
98
1.47
0.59
8.9
8.2
—
—
—
0
0
9
60
1.53
0.55
2.0
6.2
130.78
175.13
%
—
9
60
9
64
1.43
0.52
2.4
1.7
—
—
—
0
0
18
137
1.36
0.50
2.0
1.8
—
—
—
0
0
18
140
1.32
0.44
2.0
1.9
—
—
—
0
0
5
33
1.53
0.41
1.6
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
5
36
1.40
0.38
1.4
1.6
—
—
—
0
0
6
42
1.45
0.36
1.0
1.2
—
—
—
0
0
6
44
1.38
0.35
1.0
1.2
—
—
—
0
0
23
194
1.22
0.32
1.7
1.4
—
—
—
0
0
8
108
0.73
0.30
1.3
1.7
—
—
—
0
0
22
186
1.21
0.30
2.2
2.2
—
—
—
0
0
93
883
1.14
0.29
3.9
4.3
11.40
10.25
mm/h
0.34
88
812
16
193
0.81
0.29
1.3
1.3
5.81
11.94
u/ml
—
10
71
10
76
1.34
0.29
2.0
1.3
—
—
—
0
0
20
169
1.21
0.27
2.2
2.0
—
—
—
0
0
8
66
1.22
0.27
2.1
11.0
92.88
97.47
%
—
8
66
100
958
1.13
0.26
3.3
3.5
—
—
—
0
0
5
39
1.29
0.23
1.2
2.9
—
—
—
0
0
23
201
1.17
0.23
2.7
3.8
695.00
345.20
ng/l
0.21
15
140
0
10
0.00
0.21
0.0
5.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
7.53
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
110
1069
1.11
0.18
4.3
3.8
5.55
5.83
mmol/l
2.22
101
983
5
65
0.76
0.17
2.4
2.0
—
—
—
0
0
17
191
0.87
0.15
1.5
1.3
10.28
35.83
iu/ml
—
6
65
11
95
1.17
0.12
1.0
1.1
—
—
—
0
0
13
116
1.13
0.09
1.8
2.6
28.92
33.28
u/l
0.25
13
96
18
179
1.01
0.00
4.1
4.2
24.92
21.33
%
—
10
88
35
351
1.00
0.00
1.8
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
121.13
—
0
8
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
57
0.87
-0.00
1.4
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
132.62
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
15.67
—
0
6
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
196.14
—
0
9
0
5
0.00
-0.00
0.0
12.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
14.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
58.43
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
10.14
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
1.24
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_KIDNEY and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_KIDNEY | 1.732 [1.2, 2.49] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 696 males with Q17_OTHER_CONGEN_MALFO_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.409% |
| 5 | No data | 2.41% |
| 10 | No data | 5.811% |
| 15 | No data | 10.542% |
| 20 | No data | 17.333% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_KIDNEY – Other congenital malformations of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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