No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
142 |
4. Check minimum number of eventsNone |
142 |
5. Include endpointsNone |
142 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[0-4]
- Name in latin
- Aliae malformationes congenitae renis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1596 | 808 | 785 |
| Only index persons | 1208 | 636 | 572 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 9.78 | 12.50 | 6.90 |
| Only index persons | 20.45 | 23.76 | 16.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 89 | 53 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 42.84 | 42.65 | 43.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 124
- Matched controls
- 1240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q63.1
ICD-10 Finland
Lobulated, fused and horseshoe kidney
+∞
54.2
48
*
Q63.2
ICD-10 Finland
Ectopic kidney
+∞
37.4
34
*
Q63.9
ICD-10 Finland
Congenital malformation of kidney, unspecified
+∞
22.6
21
*
Q63.88
ICD-10 Finland
Other specified congenital malformations of kidney
+∞
18.2
17
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
11.0
13.6
26
29
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
39.1
11.5
14
*
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
10.6
10
*
UKC02
NOMESCO Finland
Cystoscopy
5.3
10.5
34
82
N18.8
ICD-10 Finland
Other chronic renal failure
28.7
10.0
13
5
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
12.9
9.9
17
15
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
9.5
9
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
20.5
9.1
13
7
A12AA04
ATC
calcium carbonate; oral
29.9
8.6
11
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
29.9
8.6
11
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
96.3
8.5
9
*
N18.0
ICD-10 Finland
End-stage renal disease
48.1
7.8
9
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
48.1
7.8
9
*
A11CC03
ATC
alfacalcidol; systemic
19.9
7.8
11
6
KA1FN
NOMESCO Finland
Isotope renography
85.0
7.5
8
*
Q63.0
ICD-10 Finland
Accessory kidney
+∞
7.4
7
*
TK800
NOMESCO Finland
Hemodialysis
21.6
7.3
10
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
32.1
7.3
9
*
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
19.2
6.4
9
5
Q63.81
ICD-10 Finland
Congenital diverticulum in renal cup
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
114
4.65
14.10
19.7
12.6
10.2
7.3
mmol/l
1.70
41
108
26
66
4.59
9.82
9.1
18.1
1.4
1.2
mg/l
0.48
26
61
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
31
6.09
9.21
3.2
19.0
0.2
0.4
u/ml
—
5
19
72
421
2.44
6.35
8.7
3.6
—
—
—
0
0
87
561
2.42
6.07
16.5
9.4
1.2
1.2
mmol/l
0.90
81
490
60
345
2.28
5.27
8.8
3.4
0.2
0.4
e6/l
0.77
51
253
41
208
2.36
4.75
6.8
3.4
1.5
2.8
e6/l
0.69
29
115
21
76
3.07
4.68
3.6
3.1
66.4
67.5
ml/min/173m2
0.05
13
30
23
93
2.76
4.22
3.2
3.2
—
—
—
0
0
47
268
2.12
4.04
7.7
3.8
24.3
16.4
mg/mmol
0.36
31
153
55
348
1.95
3.48
4.6
3.7
2.3
2.4
mmol/l
0.31
49
311
29
144
2.27
3.46
14.5
14.5
24.1
25.0
mmol/l
0.86
29
144
38
218
2.01
3.14
5.8
3.1
1.0
0.8
e6/l
0.20
25
122
78
567
1.83
3.12
5.8
3.8
0.0
0.0
estimate
0.00
19
90
79
577
1.83
3.10
5.9
3.8
0.0
0.0
estimate
0.00
20
87
44
267
1.94
3.09
2.3
2.8
—
—
—
0
0
19
84
2.45
2.92
8.1
7.4
116.7
119.9
g/l
0.26
19
79
31
170
2.05
2.88
7.7
2.6
12.4
13.8
umol/l
0.65
31
160
77
570
1.76
2.79
8.1
5.3
0.0
0.0
estimate
0.00
19
93
72
523
1.76
2.79
4.4
3.9
—
—
—
0
0
5
6
8.57
2.77
1.6
1.0
8.9
11.0
umol/l
—
5
6
23
115
2.19
2.69
10.2
10.8
24.0
23.8
mmol/l
0.19
23
108
24
125
2.11
2.54
13.4
12.6
1.1
1.5
mmol/l
0.33
12
97
14
58
2.57
2.45
11.6
9.6
94.3
94.0
%
0.08
14
58
6
12
5.16
2.42
1.0
1.5
—
—
—
0
0
10
35
3.00
2.35
1.4
1.6
—
—
—
0
0
17
82
2.22
2.17
2.9
1.6
—
—
—
0
0
36
234
1.72
1.96
4.4
4.4
351.8
5028.9
umol/l
1.07
31
206
20
108
1.99
1.93
9.1
7.0
5.1
5.3
kpa
0.42
20
101
12
54
2.33
1.79
8.1
9.4
23.9
24.5
mmol/l
0.24
12
49
41
286
1.61
1.70
6.7
4.2
0.0
0.0
estimate
0.49
20
87
55
416
1.52
1.59
5.9
3.8
—
—
—
0
0
13
65
2.10
1.54
1.8
1.2
—
—
—
0
0
111
980
1.60
1.51
22.3
11.0
77.9
88.3
ml/min/173m2
3.34
99
777
0
39
0.00
1.36
0.0
1.5
—
—
—
0
0
99
867
1.47
1.27
3.9
3.8
14.8
14.5
pmol/l
0.44
92
791
116
1054
1.55
1.18
4.5
4.3
1.7
1.9
mu/l
0.93
106
959
0
35
0.00
1.17
0.0
1.6
—
—
—
0
0
5
20
2.55
1.16
1.2
1.9
—
—
—
0
0
10
53
1.95
1.04
2.4
1.6
—
—
—
0
0
34
256
1.43
0.97
2.0
3.4
1.3
0.8
mg/l
0.81
27
204
0
32
0.00
0.96
0.0
1.4
—
—
—
0
0
10
55
1.88
0.94
10.6
6.3
23.9
25.2
mmol/l
—
10
48
15
95
1.65
0.91
2.3
4.7
4.5
5.6
ug/l
—
9
78
8
42
1.96
0.90
3.0
1.2
—
—
—
0
0
43
343
1.36
0.88
3.2
3.4
27.7
30.6
ng/l
0.12
31
212
8
44
1.86
0.87
2.6
2.5
—
—
—
0
0
6
31
1.97
0.85
4.2
2.0
—
—
—
0
0
8
46
1.78
0.84
1.5
1.1
—
—
—
0
0
45
366
1.33
0.81
2.4
1.8
94.9
97.6
pmol/l
0.11
21
185
125
1178
1.50
0.80
24.8
13.3
27.6
22.0
mg/l
0.82
103
884
6
33
1.85
0.80
1.0
2.9
—
—
—
0
0
80
707
1.30
0.79
8.6
12.2
3.6
3.9
e9/l
0.62
73
608
5
24
2.12
0.75
1.2
1.5
—
—
—
0
0
5
24
2.12
0.75
1.2
1.7
—
—
—
0
0
7
40
1.79
0.72
2.0
1.3
—
—
—
0
0
7
40
1.79
0.72
1.9
1.2
—
—
—
0
0
5
26
1.95
0.71
1.2
1.9
—
—
—
0
0
5
91
0.53
0.70
1.8
2.0
—
—
—
0
0
24
182
1.38
0.67
2.2
2.0
—
—
—
0
0
10
62
1.66
0.67
2.4
3.8
4.3
4.7
pmol/l
—
10
54
6
105
0.55
0.64
1.3
1.7
—
—
—
0
0
5
30
1.69
0.62
1.0
1.1
—
—
—
0
0
6
37
1.65
0.56
1.2
1.2
—
15.2
—
0
7
121
1151
1.34
0.56
20.2
15.3
38.8
39.7
%
0.63
99
940
9
62
1.48
0.54
2.4
1.7
—
—
—
0
0
7
107
0.64
0.51
2.1
2.1
—
—
—
0
0
7
45
1.58
0.49
1.9
1.7
—
—
—
0
0
40
341
1.24
0.49
1.2
1.5
1.0
1.5
u/ml
0.27
13
68
5
31
1.63
0.43
1.6
1.3
—
—
—
0
0
8
57
1.43
0.43
2.0
6.5
133.3
177.3
%
—
8
57
5
32
1.58
0.42
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
17
133
1.32
0.40
2.1
1.8
—
—
—
0
0
23
188
1.27
0.40
1.7
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
5
35
1.44
0.39
1.4
1.6
—
—
—
0
0
111
1059
1.22
0.39
5.3
4.4
2.7
2.8
mmol/l
0.44
106
982
97
918
1.18
0.35
3.4
3.5
—
—
—
0
0
17
136
1.28
0.35
2.1
1.9
—
—
—
0
0
90
850
1.16
0.33
3.7
4.3
11.2
10.1
mm/h
0.31
85
780
12
95
1.29
0.27
6.0
8.4
—
—
—
0
0
9
74
1.23
0.26
2.1
1.3
—
—
—
0
0
5
40
1.26
0.22
1.0
1.2
—
—
—
0
0
5
42
1.20
0.21
1.0
1.2
—
—
—
0
0
21
183
1.17
0.21
2.3
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
6.4
—
0
5
0
10
0.00
0.21
0.0
5.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
22
193
1.16
0.21
2.8
3.7
695.0
365.2
ng/l
0.20
15
132
16
186
0.84
0.21
1.3
1.3
5.8
12.3
u/ml
—
10
69
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
19
167
1.16
0.18
2.2
2.0
—
—
—
0
0
11
92
1.21
0.16
1.0
1.1
—
—
—
0
0
13
111
1.19
0.16
1.8
2.6
28.9
33.6
u/l
0.27
13
91
106
1034
1.10
0.14
4.3
3.8
5.5
5.8
mmol/l
2.85
98
948
18
174
1.04
0.00
4.1
4.2
24.9
21.4
%
—
10
86
34
335
1.02
0.00
1.9
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
10.1
—
0
6
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
1.2
—
0
6
0
7
0.00
0.00
0.0
1.7
—
58.4
—
0
7
5
55
0.91
0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
197.3
—
0
8
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
132.1
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
144.9
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
12.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
16.6
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_KIDNEY and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_KIDNEY | 1.732 [1.2, 2.49] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 696 males with Q17_OTHER_CONGEN_MALFO_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.409% |
| 5 | No data | 2.41% |
| 10 | No data | 5.811% |
| 15 | No data | 10.542% |
| 20 | No data | 17.333% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_KIDNEY – Other congenital malformations of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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