Malignant neoplasm of nasopharynx, excluding all cancers (controls excluding all cancers)

C3_NASOPHARYNX_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C11
  • Hospital discharge: ICD-9 147
  • Hospital discharge: ICD-8 147
  • Cause of death: ICD-10 C11
  • Cause of death: ICD-9 147
  • Cause of death: ICD-8 147
  • Cancer registry: Topography ICD-O-3 C11
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

164

4. Check minimum number of events

None

164

5. Include endpoints

None

164

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of nasopharynx, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 164 61 103
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 61.38 58.39 63.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
96
Matched controls
960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
63.8
54
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
+∞
48.0
42
*
A03FA01
ATC
metoclopramide; systemic, rectal
30.8
42.1
61
51
JDB10
NOMESCO Finland
Percutaneous gastrostomy
322.6
41.4
39
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
40.4
40.6
52
27
WF002
NOMESCO Finland
Radical radiotherapy
521.2
36.6
34
*
8070/3-C11.9
ICD-O-3
Squamous cell carcinoma, NOS, of nasopharynx, NOS
+∞
35.7
32
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
32.1
29
*
C11.9
ICD-10 Finland
Malignant neoplasm: Nasopharynx, unspecified
+∞
32.1
29
*
H02AB02
ATC
dexamethasone; systemic
214.9
30.6
30
*
N02AA05
ATC
oxycodone; systemic
18.1
26.0
43
41
A04AA02
ATC
granisetron; systemic, transdermal
+∞
25.1
23
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
10.8
24.8
63
144
EMA30
NOMESCO Finland
Biopsy of rhinopharynx
+∞
23.9
22
*
C11.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of nasopharynx
+∞
22.8
21
*
A04AA01
ATC
ondansetron; systemic, rectal
55.4
21.7
25
6
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
249.3
20.4
20
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
249.3
20.4
20
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
19.4
18
*
XX3DW
NOMESCO Finland
Time consuming IT work
22.7
19.4
28
17
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
+∞
18.3
17
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
18.3
17.9
28
21
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
109.5
17.2
18
*
D10.6
ICD-10 Finland
Benign neoplasm: Nasopharynx
+∞
17.2
16
*
C11.1
ICD-10 Finland
Malignant neoplasm: Posterior wall of nasopharynx
+∞
17.2
16
*
C11.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of nasopharynx
+∞
17.2
16
*
C11.0
ICD-10 Finland
Malignant neoplasm: Superior wall of nasopharynx
+∞
17.2
16
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
+∞
16.1
15
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
15.0
14
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
15.0
14
*
H65.2
ICD-10 Finland
Chronic serous otitis media
63.2
14.3
16
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
15.5
14.0
23
19
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
13.9
13
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
13.9
13
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
27.2
13.5
18
8
EP1AE
NOMESCO Finland
Neck ultrasound examination
14.6
13.1
22
19
EBA10
NOMESCO Finland
Surgical removal of tooth
9.2
12.9
28
41
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.8
12
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
11.7
11
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
40.4
11.6
14
*
A07AA02
ATC
nystatin; oral
11.7
10.9
20
21
L03AA13
ATC
pegfilgrastim; parenteral
+∞
10.6
10
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
10.6
10
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
10.6
10
*
8010/3-C11.9
ICD-O-3
Carcinoma, NOS, of nasopharynx, NOS
+∞
10.6
10
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
10.6
10
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
10.6
10
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
45.1
10.2
12
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
45.1
10.2
12
*
JN4BD
NOMESCO Finland
Extensive body CT
13.5
10.0
17
15
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
7.0
9.8
25
46
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
110.5
9.6
10
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
110.5
9.6
10
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
9.5
9
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
9.5
9
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
+∞
9.5
9
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
9.5
9
*
A04AD12
ATC
aprepitant; systemic
+∞
9.5
9
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.1
9.2
32
86
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
12.5
9.2
16
15
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
22.5
8.7
12
6
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
98.3
8.6
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
8.4
8
*
9680/3-C11.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of nasopharynx, NOS
+∞
8.4
8
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
8.4
8
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
8.4
8
*
R13
ICD-10 Finland
Dysphagia
8.6
8.4
18
25
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
8.3
36
120
WX199
NOMESCO Finland
Other local analgesia
14.8
8.2
13
10
UDM02
NOMESCO Finland
Sinoscopy
15.0
7.6
12
9
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
8.5
7.6
16
22
D70.82
ICD-10 Finland
Drug-induced neutropenia
86.5
7.5
8
*
K11.70
ICD-10 Finland
Hypoptyalism
86.5
7.5
8
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
7.4
7
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
7.4
7
*
8070/3-C11.2
ICD-O-3
Squamous cell carcinoma, NOS, of lateral wall of nasopharynx
+∞
7.4
7
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
+∞
7.4
7
*
J01CE02
ATC
phenoxymethylpenicillin; oral
3.7
7.1
77
500
Z51.5
ICD-10 Finland
Palliative care
15.3
7.1
11
8
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.2
6.9
52
258
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.9
6.9
14
18
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.8
6.8
13
15
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.5
6.8
20
44
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
74.6
6.5
7
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
10.4
6.5
12
13
TDA90
NOMESCO Finland
Removal wax from ear
28.8
6.3
8
*
A01AB09
ATC
miconazole; local oral
5.6
6.3
18
38
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
8070/3-C11.1
ICD-O-3
Squamous cell carcinoma, NOS, of posterior wall of nasopharynx
+∞
6.3
6
*
JN6AD
NOMESCO Finland
CT of torso and neck
+∞
6.3
6
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
8072/3-C11.9
ICD-O-3
Squamous cell carcinoma, large cell, nonkeratinizing, NOS, of nasopharynx, NOS
+∞
6.3
6
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.6
6.3
14
21
WX110
NOMESCO Finland
Local anesthesy
3.2
6.3
71
452
JN4AD
NOMESCO Finland
Body CT examination
9.6
6.3
12
14
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
6.6
6.1
15
26
WZC30
NOMESCO Finland
Teaching
5.0
6.1
19
45
H66.9
ICD-10 Finland
Otitis media, unspecified
9.0
6.0
12
15
EMB10
NOMESCO Finland
Tonsillectomy
16.3
6.0
9
6

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_NASOPHARYNX_EXALLC – Malignant neoplasm of nasopharynx, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).