Neuroendocrine tumor and carcinoma of rectum, excluding all cancers (controls excluding all cancers)

C3_RECTUM_NEUROENDOCRINE_EXALLC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C19|C20
  • Cancer registry: Morphology ICD-O-3 8240|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

124

4. Check minimum number of events

None

124

5. Include endpoints

None

124

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Neuroendocrine tumor and carcinoma of rectum, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 124 72 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 56.48 53.92 60.03

-FinnGen-

Age distribution of first events

010203040506070051015202530AgeIndividuals

-FinnGen-

Year distribution of first events

1970197519801995200020052010201520202023024681012141618202224YearIndividuals

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
113
Matched controls
1130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
125.6
96
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
32.7
46.3
64
43
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
33.0
34.0
45
22
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
22.6
21
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
+∞
20.4
19
*
UJF32
NOMESCO Finland
Coloscopy
5.5
15.0
56
171
130
Kela drug reimbursment
Malignant tumour
+∞
13.8
13
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
12.7
12
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
11.7
11
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
11.7
11
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
11.7
11
*
UJF30
NOMESCO Finland
Ileoscopy through colon
7.4
11.4
28
48
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
10.6
10
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
10.6
10.0
19
21
K62.1
ICD-10 Finland
Rectal polyp
26.5
9.1
12
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
7.8
54
249
H02AB02
ATC
dexamethasone; systemic
27.1
7.7
10
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
7.4
7
*
JN4BD
NOMESCO Finland
Extensive body CT
7.3
6.6
15
23
A04AA01
ATC
ondansetron; systemic, rectal
19.3
6.4
9
5
WF002
NOMESCO Finland
Radical radiotherapy
+∞
6.3
6
*
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
6.3
6
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
6.0
6.1
16
30

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
26
17.64
37.24
1.5
1.1
—
—
—
0
0
43
101
5.99
18.70
1.8
1.3
—
—
—
0
0
24
59
4.80
9.49
3.8
1.4
27.52
7.99
ug/l
0.35
19
44
75
396
3.26
9.46
5.8
3.4
35.51
35.81
g/l
0.17
69
367
9
6
16.03
6.00
2.7
1.7
14.51
23.53
ug/l
—
9
6
57
317
2.48
5.69
2.6
1.6
—
—
—
0
0
63
371
2.42
5.50
10.4
8.0
1.25
1.29
inr
0.12
21
104
53
302
2.32
4.85
5.5
2.0
2.37
2.35
mmol/l
0.49
48
246
21
75
3.17
4.84
1.2
1.1
—
—
—
0
0
13
36
3.92
4.33
1.6
1.2
—
—
—
0
0
15
52
3.14
3.61
5.1
7.3
24.47
25.35
mmol/l
0.45
15
52
25
122
2.31
3.14
3.0
2.0
56.26
131.15
ug/g
1.77
19
88
96
772
2.08
2.94
4.0
4.0
14.48
11.52
mm/h
0.84
89
701
42
259
1.94
2.88
2.3
1.8
—
—
—
0
0
61
425
1.86
2.88
15.9
8.1
0.00
0.00
e9/l
0.00
53
342
5
6
8.61
2.77
1.2
1.5
—
—
—
0
0
36
216
1.94
2.65
9.7
4.7
—
—
—
0
0
72
540
1.79
2.57
12.0
5.7
4.41
4.18
e9/l
0.32
64
460
5
7
7.38
2.57
1.2
1.7
93.28
92.00
%
—
5
7
43
278
1.84
2.51
2.5
2.6
0.20
0.47
e6/l
1.13
28
201
42
274
1.81
2.36
5.4
3.4
7.42
7.40
ph
0.58
13
39
51
353
1.76
2.35
2.9
3.2
19.49
100.37
e6/l
1.52
32
234
16
73
2.37
2.33
6.4
8.1
—
—
—
0
0
7
18
4.06
2.29
2.9
3.4
9.26
8.25
kpa
—
7
18
7
18
4.06
2.29
2.9
3.4
4.70
4.96
kpa
—
7
18
61
451
1.69
2.18
7.3
5.5
1.22
1.21
mmol/l
0.20
50
390
63
476
1.66
2.03
3.5
4.2
0.00
0.00
estimate
0.00
13
90
43
295
1.70
1.99
2.7
2.7
72.34
266.51
e6/l
0.39
29
218
40
269
1.72
1.99
2.5
2.5
—
—
—
0
0
61
460
1.64
1.96
9.3
5.2
8.51
8.45
%
0.04
55
419
5
11
4.69
1.96
1.2
1.4
2.48
339.23
u/ml
—
5
11
6
16
3.88
1.96
1.0
1.2
—
—
—
0
0
114
1026
2.38
1.92
17.1
11.2
17.64
21.50
mg/l
0.87
93
773
7
22
3.31
1.91
2.9
1.6
—
—
—
0
0
16
80
2.15
1.90
2.5
3.0
63.88
67.85
e9/l
—
8
66
66
512
1.62
1.87
9.0
4.9
0.19
0.19
e9/l
0.15
56
443
5
12
4.29
1.84
1.0
1.3
—
—
—
0
0
117
1078
2.51
1.84
15.0
10.3
—
—
—
0
0
19
104
1.98
1.79
1.8
2.8
1.68
1.60
%
0.13
14
93
61
470
1.59
1.74
9.2
5.1
28.41
28.10
%
0.07
56
425
5
13
3.96
1.73
2.2
2.8
29.80
33.85
pg
—
5
13
61
472
1.58
1.70
2.9
3.1
0.00
0.00
estimate
0.00
13
91
12
56
2.27
1.67
1.2
1.3
—
—
—
0
0
5
14
3.67
1.63
1.0
1.2
—
—
—
0
0
57
438
1.56
1.61
9.5
5.0
0.63
0.71
%
0.57
52
396
59
457
1.56
1.61
9.3
5.0
2.74
3.03
%
0.43
54
414
36
248
1.64
1.61
1.4
1.3
—
—
—
0
0
62
486
1.55
1.61
2.8
3.1
0.00
0.00
estimate
0.00
12
85
15
80
2.00
1.52
3.2
2.9
—
—
—
0
0
47
350
1.55
1.51
3.1
3.1
7.96
7.53
mmol/l
0.27
40
291
28
184
1.67
1.49
2.3
2.4
479.59
552.66
mosm/kgh2o
0.92
22
154
17
96
1.89
1.48
1.4
1.5
—
—
—
0
0
36
253
1.60
1.48
3.4
3.5
0.00
0.00
estimate
0.00
13
87
59
465
1.51
1.45
9.3
4.9
56.64
57.33
%
0.15
54
425
80
674
1.53
1.42
4.2
3.6
—
—
—
0
0
30
204
1.62
1.40
2.2
2.1
3.00
5.26
e6/l
1.28
22
177
29
196
1.63
1.39
1.9
1.7
470.65
449.64
pmol/l
0.21
23
153
42
311
1.53
1.37
8.3
5.1
—
—
—
0
0
22
139
1.71
1.35
1.2
1.2
—
—
—
0
0
61
490
1.48
1.34
9.4
4.9
0.59
0.57
e9/l
0.18
53
413
85
731
1.52
1.32
4.5
3.7
—
—
—
0
0
61
494
1.46
1.27
9.5
4.9
0.04
0.04
e9/l
0.91
54
420
5
19
2.70
1.23
6.8
2.6
—
—
—
0
0
30
211
1.56
1.22
5.2
4.4
—
—
—
0
0
40
302
1.48
1.17
4.2
3.8
—
—
—
0
0
61
500
1.43
1.16
9.5
5.0
2.30
1.91
e9/l
0.38
54
435
43
331
1.46
1.14
3.1
3.3
19.52
263.36
mg/l
0.68
26
212
30
217
1.50
1.07
4.2
3.8
—
—
—
0
0
16
99
1.71
1.06
1.6
1.7
—
—
—
0
0
18
118
1.61
0.97
1.4
1.5
—
—
—
0
0
25
178
1.51
0.96
1.8
1.6
1358.78
1276.82
nmol/l
0.14
18
129
44
352
1.39
0.92
4.1
3.9
2.69
10.46
mg/mmol
2.41
26
219
17
114
1.57
0.85
3.1
1.4
—
—
—
0
0
19
135
1.48
0.74
1.6
1.9
—
—
—
0
0
27
206
1.40
0.74
1.1
1.3
2.27
2.61
g/l
—
10
110
21
154
1.44
0.71
2.9
2.6
0.77
2.90
e6/l
1.16
11
68
7
42
1.71
0.69
1.6
1.1
—
—
—
0
0
33
266
1.33
0.65
2.8
2.8
—
—
—
0
0
8
50
1.64
0.63
1.3
1.6
—
—
—
0
0
12
80
1.55
0.62
1.2
1.3
—
—
—
0
0
5
30
1.69
0.62
1.2
1.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.1
—
65.25
—
0
21
0
22
0.00
0.60
0.0
1.0
—
—
—
0
0
12
81
1.53
0.59
1.0
1.1
—
—
—
0
0
6
38
1.61
0.55
1.8
1.5
—
—
—
0
0
27
220
1.29
0.49
1.4
1.6
1.75
1.14
mg/l
0.40
20
168
43
374
1.23
0.46
2.9
2.8
—
—
—
0
0
10
69
1.49
0.46
3.2
1.2
—
—
—
0
0
48
423
1.22
0.45
2.3
1.8
88.61
96.67
pmol/l
0.72
27
195
14
183
0.74
0.44
1.4
1.3
1.20
11.65
u/ml
—
5
66
5
32
1.59
0.42
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
3.6
—
7.05
—
0
17
0
18
0.00
0.40
0.0
3.5
—
1.62
—
0
18
12
89
1.39
0.39
1.8
1.4
—
—
—
0
0
101
965
1.25
0.38
5.3
4.5
1.97
1.93
mu/l
0.11
93
873
6
42
1.45
0.36
2.8
3.5
—
—
—
0
0
108
1042
1.28
0.35
5.1
4.5
6.19
5.99
mmol/l
0.78
98
952
12
92
1.34
0.33
5.3
3.7
—
—
—
0
0
26
222
1.22
0.33
1.3
1.2
0.49
0.80
u/ml
—
7
51
7
54
1.31
0.31
7.4
8.9
0.80
1.54
%
—
7
54
26
224
1.20
0.30
2.8
3.0
—
—
—
0
0
7
56
1.26
0.30
2.9
2.5
—
—
—
0
0
10
129
0.76
0.30
2.6
1.9
—
—
—
0
0
44
399
1.16
0.29
4.4
3.3
21.18
40.83
ng/l
1.39
34
267
107
1041
1.20
0.24
4.4
4.6
1.43
1.50
mmol/l
0.99
97
962
5
41
1.23
0.22
2.6
2.5
24.20
25.42
mmol/l
—
5
41
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
106.33
—
0
12
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
4.09
—
0
12
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
5
67
0.74
0.17
1.2
1.8
—
—
—
0
0
8
70
1.15
0.16
1.1
1.4
—
—
—
0
0
107
1050
1.14
0.14
4.5
4.6
4.52
4.70
mmol/l
1.02
98
973
12
105
1.16
0.11
1.1
1.5
—
—
—
0
0
95
930
1.09
0.11
18.9
12.5
40.63
40.49
%
0.08
60
663
102
1003
1.10
0.10
6.7
5.9
41.28
40.17
mmol/mol
0.50
94
939
10
87
1.16
0.10
5.8
7.5
114.00
122.37
g/l
—
10
87
6
53
1.14
0.09
8.5
9.0
0.72
0.71
%
—
6
53
5
63
0.79
0.08
3.2
4.4
—
—
—
0
0
7
68
1.03
0.08
4.0
2.6
—
—
—
0
0
8
77
1.04
0.07
1.8
1.4
—
27.47
—
0
6
31
295
1.07
0.07
1.5
1.6
1.43
1.34
mmol/l
0.23
26
250
27
260
1.05
0.03
2.8
2.5
—
—
—
0
0
108
1071
1.07
0.03
5.1
5.2
2.58
2.76
mmol/l
1.26
99
984
37
378
0.97
0.02
2.8
3.0
—
—
—
0
0
101
1003
1.04
0.01
4.1
4.1
1.40
1.29
mmol/l
0.84
92
923
79
786
1.01
0.00
4.9
3.7
15.03
14.75
pmol/l
0.38
73
706
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.32
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
0.00
1.7
1.4
2.45
1.20
g/l
—
6
53
9
92
0.98
0.00
6.2
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
7.06
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
8
80
1.00
0.00
2.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
13.14
—
0
9
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
43.40
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
8
88
0.90
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
95.16
—
0
7
7
70
1.00
0.00
4.9
1.8
10.76
11.16
g/l
—
7
65
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
10.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_RECTUM_NEUROENDOCRINE_EXALLC – Neuroendocrine tumor and carcinoma of rectum, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).