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Neuroendocrine tumor and carcinoma of rectum

C3_RECTUM_NEUROENDOCRINE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C19|C20
  • Cancer registry: Morphology ICD-O-3 8240|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

124

4. Check minimum number of events

None

124

5. Include endpoints

None

124

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Similar endpoints

List of similar endpoints to Neuroendocrine tumor and carcinoma of rectum based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 124 72 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 56.48 53.92 60.03

-FinnGen-

Age distribution of first events

010203040506070051015202530AgeIndividuals

-FinnGen-

Year distribution of first events

1970197519801995200020052010201520202023024681012141618202224YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
113
Matched controls
1131
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
125.6
96
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
34.3
47.1
64
41
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
27.8
32.3
45
26
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
254.7
21.3
21
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
56.4
16.6
19
*
UJF32
NOMESCO Finland
Coloscopy
4.9
13.3
56
189
K62.1
ICD-10 Finland
Rectal polyp
132.8
11.6
12
*
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
10.6
10
*
UJF30
NOMESCO Finland
Ileoscopy through colon
5.6
9.3
28
62
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
9.3
9.3
19
24
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
7.9
54
245
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
20.0
7.8
11
6
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
12.0
7.0
12
11
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
6
48.96
20.36
4.0
2.3
67.21
56.83
nmol/l
—
24
6
43
121
4.91
14.87
1.8
1.3
—
—
—
0
0
34
100
4.31
10.82
1.5
1.3
—
—
—
0
0
75
453
2.66
6.52
5.8
4.3
35.51
35.52
g/l
0.00
69
424
9
12
7.98
4.44
2.7
1.7
14.51
14.53
ug/l
—
9
12
63
431
1.94
3.25
10.4
7.6
1.25
1.20
inr
0.16
21
126
53
345
1.94
3.14
5.5
3.3
2.37
2.35
mmol/l
0.59
48
297
15
58
2.80
3.00
5.1
6.0
24.47
25.11
mmol/l
0.31
15
58
25
127
2.21
2.86
3.0
2.2
56.26
166.17
ug/g
1.75
19
98
96
776
2.05
2.84
4.0
4.3
14.48
12.47
mm/h
0.49
89
707
13
51
2.73
2.53
1.6
1.3
—
—
—
0
0
57
411
1.72
2.25
2.6
2.0
—
—
—
0
0
24
132
2.01
2.23
3.7
4.4
27.52
10.90
ug/l
0.29
19
104
5
9
5.73
2.23
1.2
2.9
93.28
90.73
%
—
5
9
47
326
1.71
2.11
3.1
2.9
7.96
7.54
mmol/l
0.26
40
269
5
10
5.16
2.09
2.2
2.2
29.80
32.10
pg
—
5
10
7
21
3.47
1.99
2.9
3.6
9.26
8.84
kpa
—
7
21
7
21
3.47
1.99
2.9
3.6
4.70
4.87
kpa
—
7
21
61
459
1.65
1.99
15.9
10.6
0.00
0.01
e9/l
0.55
53
383
6
16
3.88
1.96
1.0
1.3
—
—
—
0
0
5
12
4.29
1.84
1.0
1.4
—
—
—
0
0
117
1079
2.49
1.84
15.0
13.6
—
—
—
0
0
21
119
1.92
1.80
1.2
1.2
—
—
—
0
0
16
83
2.07
1.74
6.4
8.3
—
—
—
0
0
114
1034
2.27
1.73
17.1
14.9
17.64
22.07
mg/l
1.08
93
821
43
307
1.61
1.67
3.1
3.1
19.52
275.37
mg/l
0.64
26
193
43
309
1.60
1.62
2.5
2.9
0.20
0.47
e6/l
1.12
28
232
51
382
1.57
1.62
2.9
3.5
19.49
77.98
e6/l
2.41
32
272
61
476
1.55
1.61
9.3
6.1
8.51
8.65
%
0.12
55
447
16
86
1.99
1.59
2.5
2.7
63.88
71.95
e9/l
—
8
68
66
533
1.51
1.44
9.0
5.9
0.19
0.19
e9/l
0.03
56
474
19
113
1.80
1.42
1.8
2.8
1.68
1.78
%
0.16
14
100
44
329
1.52
1.37
4.1
3.7
2.69
9.38
mg/mmol
2.40
26
204
61
490
1.48
1.34
9.2
5.9
28.41
27.61
%
0.19
56
454
85
731
1.52
1.32
4.5
4.0
—
—
—
0
0
59
473
1.47
1.30
9.3
5.8
2.74
2.81
%
0.08
54
441
36
262
1.53
1.26
9.7
7.5
—
—
—
0
0
57
457
1.46
1.24
9.5
5.9
0.63
0.69
%
0.37
52
424
63
515
1.45
1.24
3.5
4.8
0.00
0.00
estimate
0.00
13
109
5
19
2.70
1.23
1.0
1.1
—
—
—
0
0
40
300
1.49
1.21
2.5
2.8
—
—
—
0
0
22
144
1.64
1.19
1.2
1.2
—
—
—
0
0
12
65
1.94
1.18
1.2
1.4
—
—
—
0
0
43
329
1.47
1.18
2.7
3.0
72.34
253.96
e6/l
0.42
29
252
72
608
1.44
1.17
12.0
9.8
4.41
4.07
e9/l
0.55
64
526
59
482
1.43
1.14
9.3
5.6
56.64
57.70
%
0.25
54
453
15
89
1.78
1.13
3.2
3.9
—
—
—
0
0
29
207
1.52
1.10
1.9
1.7
470.65
473.95
pmol/l
0.03
23
175
42
325
1.44
1.08
5.4
4.1
7.42
7.40
ph
0.76
13
59
42
326
1.44
1.06
2.3
2.4
—
—
—
0
0
42
328
1.42
1.02
8.3
5.6
—
—
—
0
0
61
509
1.39
1.01
2.9
3.6
0.00
0.00
estimate
0.00
13
108
61
509
1.39
1.01
7.3
6.5
1.22
1.21
mmol/l
0.21
50
431
80
699
1.41
1.01
4.2
4.0
—
—
—
0
0
0
29
0.00
0.99
0.0
3.9
—
7.48
—
0
29
0
29
0.00
0.99
0.0
4.1
—
1.49
—
0
29
0
28
0.00
0.99
0.0
1.3
—
—
—
0
0
23
160
1.54
0.98
1.6
1.8
29.74
29.00
s
0.28
23
155
62
522
1.38
0.96
2.8
3.6
0.00
0.00
estimate
0.00
12
101
40
313
1.41
0.95
4.2
4.2
—
—
—
0
0
61
517
1.35
0.89
9.4
5.8
0.59
0.58
e9/l
0.05
53
448
61
518
1.35
0.87
9.5
5.9
0.04
0.04
e9/l
0.43
54
451
36
281
1.40
0.87
1.4
1.3
—
—
—
0
0
30
230
1.40
0.80
2.2
2.6
3.00
4.41
e6/l
0.79
22
204
17
116
1.54
0.79
1.4
1.6
—
—
—
0
0
25
187
1.42
0.76
1.8
1.6
1358.78
1274.78
nmol/l
0.15
18
135
28
214
1.40
0.76
2.3
2.9
479.59
562.55
mosm/kgh2o
1.11
22
184
108
1014
1.50
0.76
5.1
4.7
6.19
5.94
mmol/l
1.11
98
930
7
39
1.84
0.74
2.9
3.1
—
—
—
0
0
5
25
2.04
0.73
6.8
2.7
—
—
—
0
0
5
25
2.04
0.73
1.2
1.2
—
—
—
0
0
16
110
1.52
0.73
1.6
1.6
—
—
—
0
0
10
155
0.61
0.71
2.6
1.9
—
—
—
0
0
61
530
1.30
0.70
9.5
5.8
2.30
2.01
e9/l
0.24
54
472
30
236
1.36
0.69
5.2
5.3
—
—
—
0
0
7
43
1.66
0.68
1.6
1.2
—
—
—
0
0
107
1011
1.43
0.63
4.4
4.7
1.43
1.50
mmol/l
0.86
97
927
36
295
1.31
0.63
3.4
3.7
0.00
0.00
estimate
0.00
13
104
17
123
1.44
0.62
3.1
1.4
—
—
—
0
0
8
51
1.61
0.62
1.3
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.8
—
—
—
0
0
12
81
1.53
0.59
1.0
1.1
—
—
—
0
0
12
81
1.53
0.59
1.2
1.4
—
—
—
0
0
6
36
1.70
0.57
1.8
1.5
—
—
—
0
0
13
91
1.48
0.55
3.9
5.9
7.15
9.09
mmol/l
0.65
13
86
27
220
1.29
0.49
1.1
1.3
2.28
2.36
g/l
—
10
122
107
1021
1.35
0.49
4.5
4.7
4.52
4.71
mmol/l
1.12
98
945
5
81
0.60
0.47
3.2
4.0
—
—
—
0
0
10
69
1.49
0.46
3.2
1.8
—
—
—
0
0
21
167
1.31
0.45
2.9
2.5
0.77
2.91
e6/l
1.45
11
88
18
140
1.33
0.45
1.4
1.5
—
—
—
0
0
101
960
1.28
0.44
5.3
4.7
1.97
1.98
mu/l
0.03
93
873
27
322
0.79
0.44
2.8
2.8
—
—
—
0
0
48
424
1.22
0.44
2.3
1.8
88.61
95.49
pmol/l
0.58
27
202
12
87
1.42
0.44
1.8
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
5
35
1.45
0.40
1.2
1.1
—
—
—
0
0
5
35
1.45
0.40
1.4
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
3.5
—
4.03
—
0
19
0
19
0.00
0.39
0.0
3.5
—
—
—
0
0
0
19
0.00
0.39
0.0
3.5
—
106.00
—
0
19
14
178
0.76
0.37
1.4
1.3
1.20
11.93
u/ml
—
5
67
108
1043
1.27
0.34
5.1
5.3
2.58
2.78
mmol/l
1.44
99
950
7
53
1.34
0.31
2.9
2.3
—
—
—
0
0
102
982
1.22
0.31
6.7
5.9
41.28
40.09
mmol/mol
0.55
94
918
33
292
1.18
0.29
2.8
3.3
—
—
—
0
0
8
62
1.31
0.29
1.7
1.4
—
33.90
—
0
5
95
912
1.18
0.28
18.9
14.8
40.63
39.92
%
0.56
60
654
19
160
1.22
0.27
1.6
1.8
—
—
—
0
0
5
72
0.68
0.27
1.2
1.8
—
—
—
0
0
12
97
1.26
0.24
1.1
1.5
—
—
—
0
0
12
98
1.25
0.22
5.3
3.8
—
—
—
0
0
101
980
1.17
0.22
4.1
4.2
1.40
1.29
mmol/l
0.89
92
897
0
11
0.00
0.21
0.0
1.1
—
676.83
—
0
6
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
1.39
—
0
10
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
4.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.26
0.20
2.8
4.0
—
—
—
0
0
27
242
1.15
0.20
1.4
1.7
1.74
1.47
mg/l
0.15
20
190
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
56.27
—
0
14
26
234
1.14
0.18
1.3
1.2
0.49
1.12
u/ml
—
7
56
30
273
1.13
0.18
4.2
4.7
—
—
—
0
0
26
236
1.13
0.16
2.8
3.4
—
—
—
0
0
8
74
1.09
0.07
1.1
1.4
—
—
—
0
0
8
76
1.06
0.07
2.0
1.5
—
—
—
0
0
7
83
0.83
0.07
4.9
1.9
10.76
10.15
g/l
—
7
77
7
83
0.83
0.07
4.0
3.4
—
—
—
0
0
44
424
1.06
0.07
4.4
4.1
21.18
37.80
ng/l
1.29
34
299
31
298
1.05
0.05
1.5
1.7
1.43
1.35
mmol/l
0.20
26
248
12
128
0.93
0.03
5.6
6.7
5.28
5.07
kpa
0.48
12
123
12
128
0.93
0.03
5.6
6.6
16.57
12.17
kpa
0.58
12
123
37
371
1.00
0.00
2.8
3.0
—
—
—
0
0
79
791
1.00
0.00
4.9
3.9
15.03
14.77
pmol/l
0.35
73
712
9
93
0.97
0.00
6.2
4.3
—
—
—
0
0
5
54
0.92
0.00
2.6
3.3
24.20
24.74
mmol/l
—
5
54
0
9
0.00
0.00
0.0
1.2
—
1.25
—
0
9
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
3.80
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
110.26
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
7.70
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
66
0.90
0.00
1.7
1.6
2.45
1.22
g/l
—
6
60
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
8
85
0.94
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
12.08
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
9.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RECTUM_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of rectum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).