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Neuroendocrine tumor and carcinoma of rectum

Endpoint Browser PheWeb

C3_RECTUM_NEUROENDOCRINE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 — C19|C20
  • Cancer registry: Morphology ICD-O-3 — 8240|8246|8249
  • Cancer registry: Behaviour codes — 3

1 out of 7 registries used, show all original rules.

138

4. Check minimum number of events

None

138

5. Include endpoints

None

138

6. Filter based on genotype QC (FinnGen only)

135

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 135 73 62
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 58.20 55.99 60.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
151.3
116
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
33.3
95.6
76
49
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
29.0
70.1
53
29
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
33.7
31
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
66.4
24.1
27
5
130
Kela drug reimbursment
Malignant tumour
+∞
23.6
22
*
UJF32
NOMESCO Finland
Coloscopy
5.6
22.8
71
220
UJF30
NOMESCO Finland
Ileoscopy through colon
7.2
20.9
37
67
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
18.1
17
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
15.9
15
*
H02AB02
ATC
dexamethasone; systemic
51.3
15.5
18
*
K62.1
ICD-10 Finland
Rectal polyp
48.1
14.5
17
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
13.8
13
*
L01BC06
ATC
capecitabine; oral
+∞
13.8
13
*
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
12.7
12
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
12.7
12
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.5
12.5
37
104
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
11.6
11
*
L01AX03
ATC
temozolomide; systemic
+∞
11.6
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
130.4
11.6
12
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.4
11.2
70
323
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
5.5
10.9
23
48
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
5.4
10.7
23
49
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
10.5
10
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
10.5
10
*
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
9.5
9
*
JG1CG
NOMESCO Finland
Extensive MRI of rectum
+∞
9.5
9
*
A04AA01
ATC
ondansetron; systemic, rectal
12.8
8.3
14
12
JN4AD
NOMESCO Finland
Body CT examination
4.8
8.0
19
44
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.0
7.7
14
14
JN4BD
NOMESCO Finland
Extensive body CT
6.7
7.7
19
32
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.0
7.5
42
176
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.4
55
268
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.4
7
*
H01CB02
ATC
octreotide; parenteral
+∞
7.4
7
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
+∞
7.4
7
*
8246/3-C20.9
ICD-O-3
Neuroendocrine carcinoma, NOS, of rectum, NOS
+∞
7.4
7
*
WF002
NOMESCO Finland
Radical radiotherapy
42.2
6.8
8
*
UJG02
NOMESCO Finland
Proctoscopy
10.8
6.7
12
12
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
6.6
17
42
N02AA05
ATC
oxycodone; systemic
3.2
6.3
29
107
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
6.3
6
*
TJF80
NOMESCO Finland
Ostomy education
+∞
6.3
6
*
C18.99
ICD-10 Finland
Malignant tumor in unspecified location in the colon other or unspecified histology
+∞
6.3
6
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
+∞
6.3
6
*
L01CB01
ATC
etoposide; systemic
+∞
6.3
6
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
6.3
6
*
116
Kela drug reimbursment
Prostate cancer
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
25
21.35
47.04
1.5
1.1
—
—
—
0
0
52
125
6.07
22.16
1.9
1.4
—
—
—
0
0
35
72
6.17
17.25
4.3
1.5
18.80
2.75
ug/l
0.49
29
54
92
490
3.63
11.86
7.2
3.5
35.44
36.22
g/l
0.66
87
460
73
372
3.04
9.48
2.6
1.6
—
—
—
0
0
87
546
2.61
6.80
18.7
12.5
1.28
1.23
inr
0.30
74
443
95
635
2.59
6.30
13.3
5.5
4.09
4.22
e9/l
0.20
80
547
27
102
3.05
5.65
1.4
1.1
—
—
—
0
0
57
327
2.27
5.03
2.4
1.9
—
—
—
0
0
90
624
2.27
4.96
9.0
5.2
0.18
0.20
e9/l
0.56
73
538
81
541
2.20
4.86
9.2
5.2
9.29
8.83
%
0.77
73
499
64
391
2.19
4.79
6.7
2.0
2.37
2.35
mmol/l
0.44
59
343
78
517
2.17
4.73
16.5
9.8
0.00
0.00
e9/l
0.50
63
418
23
90
2.87
4.50
9.0
10.2
—
—
—
0
0
61
374
2.13
4.45
7.4
5.1
—
—
—
0
0
82
563
2.12
4.44
9.0
6.1
1.22
1.21
mmol/l
0.40
69
493
79
539
2.09
4.30
9.3
5.2
0.64
0.69
%
0.38
72
494
79
540
2.08
4.27
9.3
5.1
2.58
3.01
%
0.99
72
498
85
599
2.09
4.21
9.3
5.2
0.59
0.56
e9/l
0.43
68
505
43
237
2.18
4.06
5.5
2.0
2.46
2.43
mmol/l
1.09
38
204
85
606
2.05
3.99
9.3
5.2
0.03
0.04
e9/l
1.36
69
515
79
549
2.03
3.98
9.4
5.1
27.55
27.47
%
0.02
74
512
24
104
2.58
3.86
2.7
2.0
70.65
67.50
e9/l
0.17
15
78
85
611
2.02
3.85
9.5
5.3
2.31
1.83
e9/l
0.41
70
538
55
345
1.99
3.62
6.0
3.2
7.40
7.40
ph
0.17
42
235
6
6
10.37
3.53
1.2
1.5
—
—
—
0
0
77
546
1.93
3.51
9.5
5.1
57.46
57.79
%
0.08
72
513
11
27
4.33
3.48
4.3
1.7
—
—
—
0
0
53
335
1.95
3.37
10.0
4.0
—
—
—
0
0
53
336
1.94
3.34
3.8
2.8
0.19
0.41
e6/l
1.16
39
237
8
15
5.59
3.24
3.4
1.5
2.86
249.42
u/ml
—
8
15
64
437
1.87
3.19
4.3
3.6
17.08
97.15
e6/l
1.64
44
291
14
51
2.94
3.09
1.6
1.3
—
—
—
0
0
49
310
1.90
3.07
1.4
1.3
—
—
—
0
0
21
97
2.37
2.95
4.6
5.6
9.02
8.91
mmol/l
0.02
21
92
30
163
2.07
2.87
3.4
2.1
78.04
124.24
ug/g
1.06
25
123
130
1168
2.95
2.86
21.5
13.0
19.30
22.38
mg/l
0.76
115
932
37
219
1.94
2.79
2.6
2.8
451.06
532.65
mosm/kgh2o
1.64
31
188
70
506
1.78
2.79
2.7
2.3
—
—
estimate
—
0
0
84
644
1.78
2.71
3.1
3.4
0.00
0.00
estimate
-0.00
19
114
82
628
1.75
2.62
3.2
3.3
0.00
0.00
estimate
-0.00
19
125
82
636
1.71
2.43
3.2
3.4
0.00
0.00
estimate
-0.00
20
128
6
12
5.17
2.43
1.8
1.0
—
—
—
0
0
55
384
1.72
2.39
4.1
2.9
53.41
207.85
e6/l
0.41
42
281
23
124
2.03
2.24
1.6
1.7
—
—
—
0
0
27
156
1.91
2.16
7.3
7.2
103.52
104.35
mmol/l
0.62
27
156
42
280
1.72
2.12
4.4
3.8
—
—
—
0
0
40
268
1.69
1.97
2.6
2.3
2.95
4.56
e6/l
1.10
35
240
5
11
4.67
1.96
1.2
1.5
93.28
91.11
%
—
5
11
39
262
1.68
1.90
6.2
4.3
—
—
—
0
0
5
12
4.28
1.84
3.2
1.4
29.20
33.42
pg
—
5
12
73
579
1.55
1.77
2.5
2.0
91.65
97.90
pmol/l
0.44
44
271
6
19
3.25
1.68
1.0
1.2
—
—
—
0
0
29
187
1.70
1.63
4.2
2.7
1.66
2.73
e6/l
0.33
16
73
14
71
2.08
1.60
1.2
1.4
—
—
—
0
0
64
503
1.51
1.56
2.8
2.9
6.59
6.12
ph
1.63
27
274
17
94
1.92
1.55
3.3
3.4
—
—
—
0
0
29
190
1.67
1.54
1.7
1.7
1294.95
1221.74
nmol/l
0.14
21
144
15
80
1.98
1.51
3.8
1.2
—
—
—
0
0
16
88
1.93
1.49
4.7
4.0
2.80
0.88
%
—
5
17
10
46
2.27
1.43
1.5
1.2
—
—
—
0
0
20
122
1.75
1.36
4.5
3.2
7.34
7.39
ph
—
8
69
23
147
1.68
1.34
1.5
1.5
—
—
—
0
0
25
164
1.64
1.32
1.3
1.2
—
—
—
0
0
129
1211
2.00
1.29
16.9
11.7
—
—
—
0
0
35
253
1.51
1.24
1.5
1.3
2.35
2.71
g/l
0.47
18
142
16
95
1.77
1.20
1.2
1.3
—
—
—
0
0
23
152
1.62
1.18
2.7
1.4
—
—
—
0
0
46
356
1.44
1.15
3.7
3.5
0.00
0.00
estimate
-0.00
19
115
107
965
1.48
1.12
28.8
16.0
14.25
13.51
%
4.40
107
955
5
21
2.43
1.10
1.0
1.3
—
—
—
0
0
19
122
1.65
1.09
1.6
1.5
—
—
—
0
0
24
164
1.56
1.08
1.7
1.9
—
—
—
0
0
21
140
1.59
1.05
7.8
7.9
7.40
7.42
ph
—
9
82
32
243
1.41
0.88
1.9
1.8
469.36
423.29
pmol/l
0.65
25
194
20
140
1.50
0.82
8.1
8.0
5.25
5.14
kpa
0.22
20
134
17
117
1.52
0.76
8.9
8.8
112.18
123.53
g/l
1.89
17
117
5
24
2.12
0.75
6.8
2.9
—
—
—
0
0
56
476
1.30
0.74
3.6
3.2
0.00
0.00
estimate
-0.00
17
101
9
56
1.65
0.74
1.3
1.5
—
—
—
0
0
14
93
1.56
0.73
3.8
1.9
9.46
11.27
g/l
0.82
14
88
12
77
1.61
0.71
1.7
1.4
1.75
1.24
g/l
0.22
12
72
7
44
1.62
0.66
1.4
1.9
183.14
376.07
ug/l
—
7
39
15
104
1.50
0.65
1.6
2.7
13.37
15.07
nmol/l
0.31
15
96
5
29
1.75
0.64
1.0
1.1
—
—
—
0
0
118
1119
1.38
0.61
6.0
5.1
1.93
1.93
mu/l
0.00
111
1020
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
57
496
1.25
0.61
3.9
3.5
6.83
7.72
mmol/l
0.97
50
420
34
278
1.30
0.59
1.4
1.6
1.71
1.15
mg/l
0.50
27
222
55
478
1.25
0.59
3.8
3.6
18.95
50.94
mg/l
2.12
34
307
124
1187
1.44
0.58
5.8
5.3
6.17
6.02
mmol/l
0.66
116
1093
122
1165
1.41
0.58
7.6
6.9
40.80
39.80
mmol/mol
0.51
114
1101
6
36
1.70
0.57
1.2
1.1
—
—
—
0
0
13
92
1.46
0.52
1.1
1.2
—
—
—
0
0
12
84
1.47
0.51
1.5
1.5
—
23.98
—
0
10
38
326
1.23
0.45
3.0
2.6
—
—
—
0
0
15
113
1.37
0.45
1.7
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.90
—
0
5
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
2.8
—
0.74
—
0
14
123
1192
1.29
0.36
5.2
5.4
1.44
1.48
mmol/l
0.55
113
1103
54
491
1.16
0.34
4.7
4.2
2.54
7.96
mg/mmol
2.40
32
304
125
1216
1.30
0.33
6.2
6.4
2.55
2.66
mmol/l
0.60
116
1126
32
281
1.18
0.30
1.4
1.3
0.46
0.83
u/ml
—
8
76
39
349
1.16
0.29
3.0
2.8
0.00
0.00
estimate
-0.00
15
98
123
1198
1.25
0.28
5.5
5.6
4.51
4.60
mmol/l
0.37
114
1113
8
66
1.22
0.27
2.0
2.4
0.63
0.56
%
—
8
66
97
929
1.15
0.27
5.2
4.0
14.97
14.71
pmol/l
0.44
91
839
8
67
1.21
0.27
2.0
2.4
0.89
1.32
%
—
8
67
5
39
1.29
0.23
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
8.89
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.6
—
13.51
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
4.12
—
0
13
0
13
0.00
0.21
0.0
2.8
—
1.20
—
0
13
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
106.00
—
0
13
0
13
0.00
0.21
0.0
1.5
—
1.79
—
0
13
6
48
1.26
0.20
1.3
1.6
—
—
—
0
0
117
1144
1.15
0.18
4.5
4.6
1.36
1.29
mmol/l
0.57
108
1053
20
224
0.87
0.17
1.4
1.3
1.17
12.65
u/ml
—
9
76
101
986
1.09
0.13
30.7
16.6
329.91
332.51
g/l
1.80
101
981
46
485
0.92
0.13
3.0
3.5
—
—
—
0
0
53
507
1.07
0.11
4.7
3.5
20.08
37.26
ng/l
1.71
42
358
30
283
1.08
0.09
4.0
3.2
1.02
1.02
kg/l
0.06
20
180
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
10
88
1.15
0.08
1.2
1.5
—
—
—
0
0
6
71
0.84
0.08
3.5
4.2
—
—
—
0
0
54
555
0.96
0.06
2.1
2.0
1.40
1.35
mmol/l
0.17
45
461
27
262
1.04
0.02
3.8
3.9
1102.33
196.90
ng/l
0.38
21
217
16
167
0.95
0.01
2.4
1.8
—
—
—
0
0
25
249
1.00
0.00
2.6
3.0
0.53
0.78
ug/l
2.20
18
158
7
78
0.89
0.00
1.1
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
38.33
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
75.14
—
0
7
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
8.17
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
84
0.95
-0.00
4.6
2.6
—
—
—
0
0
5
50
1.00
-0.00
5.6
8.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
139.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
119.40
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_RECTUM_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of rectum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).