Neuroendocrine tumor and carcinoma of rectum

C3_RECTUM_NEUROENDOCRINE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C19|C20
  • Cancer registry: Morphology ICD-O-3 8240|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

127

4. Check minimum number of events

None

127

5. Include endpoints

None

127

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 124 70 54
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 56.85 53.92 60.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
127
Matched controls
1270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
141.4
108
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
35.3
91.2
71
44
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
33.4
70.8
51
25
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
28.2
26
*
UJF32
NOMESCO Finland
Coloscopy
5.6
20.8
64
196
130
Kela drug reimbursment
Malignant tumour
+∞
19.2
18
*
UJF30
NOMESCO Finland
Ileoscopy through colon
7.0
18.2
33
61
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
49.7
17.9
21
5
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
16.0
15
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
13.8
13
*
K62.1
ICD-10 Finland
Rectal polyp
52.0
12.1
14
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
11.6
11
*
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
11.6
11
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
11.6
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
11.6
11
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.7
11.6
32
85
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
6.0
11.3
22
43
H02AB02
ATC
dexamethasone; systemic
31.1
11.0
14
5
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
10.6
10
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
9.8
63
294
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
9.5
9
*
L01BC06
ATC
capecitabine; oral
+∞
9.5
9
*
L01AX03
ATC
temozolomide; systemic
+∞
9.5
9
*
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
8.4
8
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
5.0
8.2
19
43
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
7.4
7
*
H01CB02
ATC
octreotide; parenteral
+∞
7.4
7
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
13.2
6.7
11
9
JN4BD
NOMESCO Finland
Extensive body CT
6.2
6.6
17
31
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
6.3
6
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
+∞
6.3
6
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
24
20.54
42.55
1.4
1.1
—
—
—
0
0
43
104
5.74
18.01
1.8
1.3
—
—
—
0
0
26
59
5.28
11.34
3.8
1.4
25.15
2.77
ug/l
0.49
21
43
77
399
3.36
10.17
5.7
3.4
35.57
35.87
g/l
0.18
71
368
75
450
2.63
6.57
18.3
11.8
1.30
1.28
inr
0.07
25
130
59
316
2.62
6.53
2.5
1.6
—
—
—
0
0
22
79
3.16
5.02
1.2
1.1
—
—
—
0
0
54
306
2.33
5.01
5.5
2.0
2.36
2.35
mmol/l
0.42
49
255
16
48
3.67
4.79
4.9
7.5
24.51
25.23
mmol/l
0.35
16
48
18
67
2.97
3.85
5.9
7.5
—
—
—
0
0
13
42
3.33
3.48
1.6
1.2
—
—
—
0
0
45
268
2.05
3.47
2.5
2.7
0.19
0.45
e6/l
1.12
30
197
38
213
2.12
3.43
9.8
4.4
—
—
—
0
0
99
788
2.16
3.26
4.0
4.0
14.25
11.60
mm/h
0.74
92
714
63
430
1.92
3.24
15.9
7.9
0.00
0.00
e9/l
0.50
55
346
44
267
1.99
3.18
2.3
1.8
—
—
—
0
0
53
344
1.93
3.15
2.9
3.3
18.82
94.56
e6/l
1.36
34
228
75
548
1.90
3.08
12.2
5.4
4.35
4.20
e9/l
0.21
67
470
5
5
10.33
3.00
1.2
1.6
—
—
—
0
0
6
9
6.93
2.90
1.8
1.4
—
—
—
0
0
25
129
2.17
2.74
3.0
2.0
56.68
127.89
ug/g
1.78
19
94
45
288
1.87
2.72
2.7
2.7
68.18
269.53
e6/l
0.40
31
214
22
108
2.25
2.72
4.4
5.8
103.91
104.43
mmol/l
0.31
22
108
6
11
5.66
2.57
1.2
1.5
2.73
339.11
u/ml
—
6
11
41
261
1.84
2.50
2.4
2.6
—
—
—
0
0
43
278
1.83
2.49
5.5
3.1
7.42
7.40
ph
0.60
13
41
63
457
1.75
2.47
8.3
5.3
—
—
—
0
0
64
468
1.74
2.43
9.4
5.1
8.53
8.45
%
0.07
58
425
63
459
1.74
2.42
7.5
5.2
1.22
1.22
mmol/l
0.13
52
399
69
517
1.73
2.39
9.0
4.8
0.18
0.19
e9/l
0.32
59
449
17
79
2.33
2.37
2.5
2.4
67.11
66.85
e9/l
—
9
65
65
484
1.70
2.27
3.6
4.3
0.00
0.00
estimate
-0.00
13
89
5
9
5.73
2.23
1.2
1.7
93.28
91.37
%
—
5
9
20
103
2.12
2.20
1.8
2.4
1.79
1.58
%
0.39
15
92
7
19
3.83
2.18
2.9
3.4
4.70
4.92
kpa
—
7
19
7
19
3.83
2.18
2.9
3.4
9.26
8.18
kpa
—
7
19
64
479
1.68
2.16
9.1
4.9
28.36
27.79
%
0.13
59
439
62
465
1.65
2.04
9.2
4.8
2.67
3.00
%
0.55
57
425
38
250
1.74
2.04
1.4
1.3
—
—
—
0
0
117
1051
2.44
2.02
17.5
11.1
17.87
21.71
mg/l
0.89
96
780
30
185
1.81
1.99
2.3
2.7
464.87
541.97
mosm/kgh2o
1.04
24
155
32
202
1.78
1.97
2.1
2.2
2.69
5.20
e6/l
1.66
25
179
5
11
4.68
1.96
2.2
1.5
29.80
33.36
pg
—
5
11
63
480
1.62
1.92
3.0
3.2
0.00
0.01
estimate
0.50
13
97
7
22
3.30
1.91
2.9
1.6
—
—
—
0
0
64
492
1.61
1.86
2.9
3.2
0.00
0.00
estimate
-0.00
12
84
6
17
3.65
1.86
1.0
1.2
—
—
—
0
0
38
256
1.69
1.86
3.6
3.5
0.00
0.00
estimate
-0.00
13
86
59
445
1.61
1.85
9.3
4.9
0.64
0.70
%
0.35
54
403
62
474
1.60
1.84
9.2
4.7
56.33
57.76
%
0.38
57
435
5
12
4.29
1.84
1.0
1.3
—
—
—
0
0
49
357
1.61
1.76
3.0
3.2
7.84
7.59
mmol/l
0.14
42
299
64
498
1.57
1.73
9.5
4.8
0.58
0.57
e9/l
0.17
56
423
64
501
1.56
1.67
9.5
4.8
0.04
0.04
e9/l
0.62
57
430
12
56
2.26
1.67
1.2
1.3
—
—
—
0
0
23
138
1.81
1.66
1.2
1.2
—
—
—
0
0
5
14
3.67
1.63
1.0
1.2
—
—
—
0
0
43
309
1.59
1.61
4.1
3.8
—
—
—
0
0
64
508
1.52
1.53
9.6
4.9
2.25
1.85
e9/l
0.41
57
447
119
1105
2.22
1.48
15.3
10.4
—
—
—
0
0
17
98
1.85
1.39
1.4
1.5
—
—
—
0
0
87
746
1.53
1.39
4.4
3.6
—
—
—
0
0
15
83
1.92
1.38
3.2
3.2
—
—
—
0
0
32
222
1.59
1.37
4.1
3.9
—
—
—
0
0
45
338
1.51
1.36
3.0
3.4
21.58
256.17
mg/l
0.67
27
219
81
686
1.50
1.36
4.2
3.6
—
—
—
0
0
17
103
1.75
1.20
1.6
1.7
—
—
—
0
0
22
146
1.61
1.13
2.8
2.6
0.79
2.96
e6/l
1.16
12
66
46
359
1.44
1.13
3.6
3.9
2.82
10.15
mg/mmol
2.31
27
226
29
206
1.53
1.12
1.9
1.8
470.65
442.25
pmol/l
0.31
23
162
5
21
2.44
1.10
6.8
3.1
—
—
—
0
0
5
21
2.44
1.10
1.4
2.7
—
—
—
0
0
26
183
1.53
1.05
1.8
1.6
1384.05
1254.94
nmol/l
0.25
19
135
18
119
1.60
0.94
3.1
1.4
—
—
—
0
0
20
136
1.56
0.94
1.5
1.8
—
—
—
0
0
18
120
1.58
0.91
1.4
1.4
—
—
—
0
0
122
1170
2.08
0.81
26.2
16.3
40.43
40.77
%
0.39
114
1081
28
212
1.41
0.79
1.1
1.3
2.37
2.70
g/l
0.28
11
114
9
54
1.72
0.76
6.7
8.6
0.99
1.57
%
—
9
54
51
428
1.32
0.76
2.4
1.9
86.40
97.04
pmol/l
1.00
30
198
11
68
1.68
0.74
3.2
1.2
—
—
—
0
0
7
42
1.70
0.69
1.6
1.1
—
—
—
0
0
34
273
1.34
0.68
2.8
2.9
—
—
—
0
0
7
44
1.62
0.66
3.3
3.5
—
—
—
0
0
28
221
1.34
0.63
1.4
1.6
1.75
1.11
mg/l
0.45
21
170
5
30
1.69
0.62
1.2
1.1
—
—
—
0
0
8
51
1.61
0.62
1.3
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
3.7
—
1.60
—
0
20
0
22
0.00
0.60
0.0
1.0
—
—
—
0
0
8
53
1.54
0.59
7.4
8.7
0.76
0.73
%
—
8
53
0
23
0.00
0.59
0.0
1.7
—
—
—
0
0
6
35
1.75
0.58
3.8
1.1
40.18
38.58
g/l
—
6
30
12
82
1.51
0.56
1.0
1.1
—
—
—
0
0
12
82
1.51
0.56
1.2
1.3
—
—
—
0
0
6
38
1.61
0.55
1.8
1.5
—
—
—
0
0
14
189
0.71
0.53
1.4
1.3
1.20
11.33
u/ml
—
5
68
104
988
1.29
0.47
5.3
4.4
1.94
1.93
mu/l
0.02
96
897
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.5
—
0.75
—
0
11
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
27
226
1.25
0.40
3.0
3.0
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
72.27
—
0
18
5
35
1.45
0.40
1.4
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
3.9
—
7.33
—
0
19
111
1070
1.30
0.38
5.1
4.4
6.17
6.00
mmol/l
0.68
101
979
12
90
1.37
0.37
5.5
7.1
113.00
123.26
g/l
1.18
12
90
6
43
1.41
0.35
2.3
2.7
24.02
25.30
mmol/l
—
6
43
12
92
1.34
0.33
1.8
1.5
—
—
—
0
0
7
56
1.26
0.30
2.9
2.6
—
—
—
0
0
110
1068
1.22
0.27
4.4
4.6
1.43
1.50
mmol/l
0.85
100
986
9
73
1.25
0.26
1.1
1.4
—
—
—
0
0
9
75
1.22
0.25
1.7
1.4
—
27.26
—
0
7
45
413
1.14
0.24
4.5
3.4
22.29
40.09
ng/l
1.29
35
284
26
229
1.17
0.24
1.3
1.3
0.49
0.82
u/ml
—
7
54
11
134
0.80
0.22
2.5
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
169.07
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.32
—
0
5
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
4.12
—
0
13
0
13
0.00
0.21
0.0
2.8
—
106.00
—
0
13
110
1076
1.17
0.18
4.6
4.6
4.52
4.69
mmol/l
0.93
101
997
7
62
1.14
0.17
1.6
1.4
2.24
1.28
g/l
—
7
56
8
71
1.14
0.16
4.5
2.6
—
—
—
0
0
8
72
1.12
0.16
4.4
1.9
10.46
11.20
g/l
—
8
67
29
266
1.12
0.15
2.7
2.6
—
—
—
0
0
82
798
1.08
0.11
4.8
3.6
14.98
14.74
pmol/l
0.34
76
719
12
106
1.15
0.10
1.1
1.5
—
—
—
0
0
38
396
0.94
0.07
2.7
3.0
—
—
—
0
0
104
1026
1.08
0.07
6.7
5.8
41.18
40.14
mmol/mol
0.47
96
961
8
94
0.84
0.07
1.4
1.3
—
—
—
0
0
104
1028
1.06
0.05
4.1
4.1
1.39
1.29
mmol/l
0.75
95
946
111
1099
1.08
0.05
5.1
5.2
2.59
2.76
mmol/l
1.09
102
1010
31
300
1.04
0.03
1.5
1.6
1.43
1.34
mmol/l
0.23
26
252
8
82
0.97
0.00
2.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
14.34
—
0
8
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
95.16
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.32
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.55
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
-0.00
3.5
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
94
0.95
-0.00
6.2
3.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
76.33
—
0
6
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
7.82
—
0
6
6
69
0.86
-0.00
1.2
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
10.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RECTUM_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of rectum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).