Colorectal neuroendocrine tumor and carcinoma

C3_COLORECTAL_NEUROENDO

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C1[8-9]|C20
  • Cancer registry: Morphology ICD-O-3 8240|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

512

4. Check minimum number of events

None

512

5. Include endpoints

None

512

6. Filter based on genotype QC (FinnGen only)

497

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 497 317 180
Unadjusted period prevalence (%) 0.10 0.11 0.08
Median age at first event (years) 51.93 47.82 59.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
512
Matched controls
5120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
+∞
174.2
157
*
8240/3-C18.2
ICD-O-3
Neuroendocrine tumor, NOS, of ascending colon
+∞
165.9
150
*
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
117.3
108
*
130
Kela drug reimbursment
Malignant tumour
+∞
104.9
97
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
9.4
91.6
126
172
JEA01
NOMESCO Finland
Laparoscopic appendectomy
14.0
89.1
88
75
H02AB02
ATC
dexamethasone; systemic
24.6
83.8
61
28
JEA00
NOMESCO Finland
Appendectomy
9.3
73.1
97
125
JN4BD
NOMESCO Finland
Extensive body CT
10.5
69.5
83
93
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
7.1
58.7
100
170
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
10.2
58.6
70
78
JFB30
NOMESCO Finland
Right hemicolectomy
125.5
53.0
56
5
UJF32
NOMESCO Finland
Coloscopy
4.1
52.9
220
791
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
+∞
48.7
46
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
12.2
45.5
47
42
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
465.3
43.9
43
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.3
41.8
133
386
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
41.2
39
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
41.2
39
*
C18.09
ICD-10 Finland
Malignant tumor of caecum other or unspecified histology
+∞
40.1
38
*
A04AA02
ATC
granisetron; systemic, transdermal
418.0
39.6
39
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
10.2
39.5
46
49
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
38.0
36
*
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
371.4
35.4
35
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
33.7
32
*
L01BC06
ATC
capecitabine; oral
+∞
32.6
31
*
H01CB03
ATC
lanreotide; parenteral
344.1
32.2
32
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
30.5
91
248
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
29.2
169
707
A04AA01
ATC
ondansetron; systemic, rectal
8.2
28.4
39
51
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
28.4
27
*
H01CB02
ATC
octreotide; parenteral
153.4
27.9
29
*
C18.01
ICD-10 Finland
Malignant tumor of the caecum invasive carcinoma
+∞
27.3
26
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
285.3
27.0
27
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
26.4
239
1255
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
26.3
25
*
C18.99
ICD-10 Finland
Malignant tumor in unspecified location in the colon other or unspecified histology
+∞
25.2
24
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
+∞
25.2
24
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
262.3
24.9
25
*
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
262.3
24.9
25
*
115
Kela drug reimbursment
Breast cancer
+∞
24.2
23
*
JN4AD
NOMESCO Finland
Body CT examination
5.0
24.0
55
121
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
23.1
22
*
ZXD05
NOMESCO Finland
Urgent procedure
2.6
22.9
194
972
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
7.9
22.7
32
43
XX3DW
NOMESCO Finland
Time consuming IT work
5.0
22.7
52
114
JN4CD
NOMESCO Finland
Very extensive body CT
20.7
22.4
33
17
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
22.0
21
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
22.0
21
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.6
21.9
79
244
PJA12
NOMESCO Finland
Sentinel node biopsy
218.5
20.7
21
*
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
+∞
19.9
19
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
57.3
19.1
22
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
18.9
18
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.4
18.2
48
118
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
17.8
17
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
186.2
17.6
18
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
32.7
17.2
22
7
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
17.0
83
308
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
65.6
16.8
19
*
8240/3-C18.0
ICD-O-3
Neuroendocrine tumor, NOS, of cecum
+∞
16.8
16
*
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
175.5
16.6
17
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
15.7
15
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
15.7
15
*
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
+∞
15.7
15
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
4.1
15.6
45
118
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
164.8
15.6
16
*
WX402
NOMESCO Finland
General anaesthesia
2.5
15.3
111
504
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
15.3
202
1185
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
15.1
80
309
Z51.5
ICD-10 Finland
Palliative care
5.5
14.8
29
55
B01AB05
ATC
enoxaparin; parenteral
2.2
14.7
171
951
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
14.7
14
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
14.7
14
*
8249/3-C18.0
ICD-O-3
Neuroendocrine tumor, grade 2 of cecum
+∞
14.7
14
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
14.7
14
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
82.5
14.6
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
154.2
14.5
15
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
14.4
164
903
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.5
14.2
52
161
WF002
NOMESCO Finland
Radical radiotherapy
43.8
14.2
17
*
HA1AA
NOMESCO Finland
X-ray mammography
4.9
13.9
31
66
L01AX03
ATC
temozolomide; systemic
+∞
13.6
13
*
ZX120
NOMESCO Finland
Intravenous
3.6
13.4
45
132
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
12.6
66
253
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
12.5
12
*
116
Kela drug reimbursment
Prostate cancer
+∞
12.5
12
*
C18.0
ICD-10 Finland
Malignant neoplasm: Caecum
+∞
12.5
12
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
133.1
12.5
13
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
133.1
12.5
13
*
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
16.4
12.2
19
12
B01AB10
ATC
tinzaparin; parenteral
3.0
11.7
55
198
JFB20
NOMESCO Finland
Ileocaecal resection
19.5
11.7
17
9
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
11.5
53
189
C18.21
ICD-10 Finland
Malignant tumor of the ascending colon invasive carcinoma
+∞
11.5
11
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
11.5
11
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
11.5
11
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
+∞
11.5
11
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
11.5
11
*
N02AA05
ATC
oxycodone; systemic
2.5
11.3
80
357
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
5.6
11.0
21
39
L03AA02
ATC
filgrastim; parenteral
61.3
10.7
12
*
L03AA13
ATC
pegfilgrastim; parenteral
61.3
10.7
12
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
112.2
10.5
11
*
D77
ICPC
Malignant digestive neopl other/NOS
112.2
10.5
11
*
15301
ICD-8 Finland
Malignant neoplasm of large intestine, except rectum, Appendicis
+∞
10.4
10
*
C18.20
ICD-10 Finland
Malignant tumor of the ascending colon without histology
+∞
10.4
10
*
8249/3-C18.1
ICD-O-3
Neuroendocrine tumor, grade 2 of appendix
+∞
10.4
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
10.4
102
522
JKA20
NOMESCO Finland
Cholecystectomy
5.3
10.4
21
41
HAB40
NOMESCO Finland
Wedge excision of mammary gland
19.3
10.3
15
8
JAH00
NOMESCO Finland
Laparotomy
5.2
10.1
21
42
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
10.0
158
961
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.3
10.0
26
63
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
20.5
9.8
14
7
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
9.6
46
168
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
101.8
9.4
10
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
9.4
9
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
9.4
9
*
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
9.4
9
*
Z2221
NOMESCO Finland
Medical doctor
1.9
9.1
142
858
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
7.7
9.0
20
27
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.7
9.0
20
27
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.9
8.7
26
70
D75
ICPC
Malignant neoplasm colon/rectum
50.9
8.7
10
*
WZC30
NOMESCO Finland
Teaching
2.3
8.6
67
311
L02BG04
ATC
letrozole; oral
7.5
8.5
19
26
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.0
8.5
24
62
ZXE00
NOMESCO Finland
One hour or less
1.8
8.4
194
1317
C18.1
ICD-10 Finland
Malignant neoplasm: Appendix
+∞
8.4
8
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
8.4
8
*
T73
ICPC
Neoplasm endocrine other/unspecified
+∞
8.4
8
*
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
8.4
8
*
L01CB01
ATC
etoposide; systemic
+∞
8.4
8
*
A79
ICPC
Malignancy NOS
+∞
8.4
8
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
8.4
8
*
C18.29
ICD-10 Finland
Malignant tumor of the ascending colon or other unspecified histology
+∞
8.4
8
*
JAH01
NOMESCO Finland
Laparoscopy
3.6
8.3
28
82
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.4
8.3
30
92
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
8.3
126
752
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
7.4
8.0
18
25
6421
FHL
Appendicectomy
2.9
7.9
37
133
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
13.3
7.9
13
10
JFB00
NOMESCO Finland
Partial resection of small intestine
13.3
7.9
13
10
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.3
7.8
20
48
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
4.0
7.8
22
57
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
7.6
7.7
17
23
R4110
NOMESCO Finland
Physiotherapy
1.8
7.6
132
819
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
25.4
7.6
10
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
7.8
7.4
16
21
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
81.2
7.4
8
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
7.3
7
*
8240/3-C18.7
ICD-O-3
Neuroendocrine tumor, NOS, of sigmoid colon
+∞
7.3
7
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
7.3
7
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.3
7
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
7.3
7
*
JN4SR
NOMESCO Finland
Very extensive PET-CT of receptors in whole body
+∞
7.3
7
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
7.3
7
*
C18.79
ICD-10 Finland
Malignant tumor of the sigmoid or other unspecified histology
+∞
7.3
7
*
C18.91
ICD-10 Finland
Malignant tumor of unspecified location in colon invasive carcinoma
+∞
7.3
7
*
8240/3-C18.9
ICD-O-3
Neuroendocrine tumor, NOS, of colon, NOS
+∞
7.3
7
*
A04AD12
ATC
aprepitant; systemic
+∞
7.3
7
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
8246/3-C18.1
ICD-O-3
Neuroendocrine carcinoma, NOS, of appendix
+∞
7.3
7
*
UJF92
NOMESCO Finland
Capsular endoscopy
5.9
7.3
19
33
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.3
217
1564
L02AE02
ATC
leuprorelin; implant, parenteral
12.3
7.1
12
10
K62.1
ICD-10 Finland
Rectal polyp
9.0
7.1
14
16
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.9
6.9
20
53
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
8.4
6.9
14
17
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.8
209
1511
NK6AN
NOMESCO Finland
Total body bone isotope imaging
40.6
6.8
8
*
TJF80
NOMESCO Finland
Ostomy education
40.6
6.8
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
6.7
50
227
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
6.7
54
254
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.7
102
606
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
12.5
6.6
11
9
ZX112
NOMESCO Finland
Subcutaneous
8.9
6.6
13
15
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
3.2
6.6
26
85
JN7AN
NOMESCO Finland
Somatostatin receptor isotope imaging
70.7
6.4
7
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
+∞
6.3
6
*
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
+∞
6.3
6
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
1535C
ICD-9 Finland
Malignant neoplasm of colon, Appendix[NEOPL MALIG APPEND VERMIF,MUU TAI MÄÄRITTELEMÄTÖN H]
+∞
6.3
6
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
6.3
6
*
C18.70
ICD-10 Finland
Malignant tumor of the sigmoid without histology
+∞
6.3
6
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
6.3
6
*
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
+∞
6.3
6
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
6.3
6
*
K35.0
ICD-10 Finland
Acute appendicitis with generalized peritonitis
7.2
6.3
14
20
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
27.0
6.2
8
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.1
6.2
18
36
WW500
NOMESCO Finland
Blood transfusion
5.5
6.2
17
32
A02BC02
ATC
pantoprazole; systemic
1.6
6.1
331
2720
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.1
209
1543
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.3
6.1
17
33
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
10.2
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
96
16.90
136.39
1.4
1.3
—
—
—
0
0
124
9
181.15
122.45
5.5
1.1
138.09
64.11
nmol/l
—
124
9
133
178
9.74
98.57
4.5
1.5
9.04
2.62
ug/l
0.85
111
133
112
306
4.40
37.89
1.2
1.1
—
—
—
0
0
124
406
3.71
32.22
1.7
1.3
—
—
—
0
0
310
1909
2.58
23.81
8.0
3.5
11.04
10.96
umol/l
0.06
299
1796
212
1094
2.60
23.65
2.3
1.9
—
—
—
0
0
41
73
6.02
22.46
2.1
1.9
98.24
77.15
u/ml
0.09
34
60
270
1612
2.43
21.39
5.7
3.5
35.97
36.21
g/l
0.34
256
1486
83
281
3.33
19.91
2.2
1.8
0.23
0.21
g/l
2.07
78
258
222
1290
2.27
17.83
2.2
1.6
—
—
—
0
0
273
1739
2.22
17.35
2.6
2.2
—
—
—
0
0
406
3054
2.59
17.33
10.0
5.2
79.62
74.48
u/l
1.25
395
2820
317
2185
2.18
16.01
10.2
6.1
4.12
4.17
e9/l
0.14
273
1908
156
840
2.23
14.52
2.2
1.9
—
—
—
0
0
207
1275
2.05
13.38
2.6
2.1
58.34
59.64
u/l
0.10
193
1172
93
413
2.53
13.32
2.1
2.0
5.58
6.07
umol/l
0.17
84
352
95
456
2.33
11.37
2.2
2.4
18.35
24.34
%
5.11
84
387
254
1767
1.87
10.81
14.4
13.9
1.20
1.27
inr
0.72
86
517
153
903
1.99
10.71
7.5
4.4
—
—
—
0
0
98
498
2.20
10.17
2.3
2.3
2.45
2.36
g/l
0.65
93
460
194
1263
1.86
9.98
4.5
2.0
2.35
2.35
mmol/l
0.19
174
1064
126
721
1.99
9.50
2.6
2.6
543.57
525.13
mosm/kgh2o
0.43
109
621
104
555
2.10
9.49
2.3
2.3
10.75
13.95
umol/l
5.33
97
511
147
893
1.91
9.27
4.3
3.6
—
—
—
0
0
253
1826
1.76
8.97
7.0
5.8
—
—
—
0
0
255
1845
1.76
8.96
7.6
5.6
8.55
8.36
%
0.45
234
1724
253
1833
1.75
8.80
7.3
5.4
2.93
2.96
%
0.09
233
1713
161
1022
1.84
8.77
2.6
2.8
0.26
0.39
e6/l
0.65
122
768
258
1890
1.74
8.54
7.4
5.5
28.71
28.52
%
0.10
238
1774
235
1678
1.74
8.52
6.3
4.9
1.21
1.22
mmol/l
0.26
221
1504
244
1762
1.74
8.49
7.5
5.4
0.72
0.70
%
0.21
224
1637
256
1875
1.73
8.45
7.1
5.2
56.55
57.06
%
0.30
236
1759
196
1343
1.74
8.13
3.2
3.4
20.23
91.59
e6/l
4.19
136
932
171
1130
1.77
8.03
2.8
2.8
41.89
111.12
e6/l
0.60
130
863
268
2023
1.68
7.64
7.2
5.2
2.00
1.91
e9/l
0.34
228
1805
270
2043
1.68
7.62
7.3
5.5
0.20
0.20
e9/l
0.21
228
1808
250
1855
1.68
7.59
7.0
5.4
1.21
1.22
mmol/l
0.50
199
1601
155
1010
1.77
7.57
2.6
2.7
—
—
—
0
0
190
1312
1.71
7.54
3.1
2.5
29.36
30.82
u/l
0.44
176
1249
330
2642
1.70
7.44
4.1
4.2
8.20
2943.75
e6/l
—
5
40
262
1976
1.67
7.42
7.2
5.2
0.04
0.04
e9/l
0.56
217
1724
260
1969
1.65
7.15
7.3
5.2
0.59
0.57
e9/l
0.34
216
1713
294
2310
1.64
6.88
5.4
4.1
6.55
6.68
mmol/l
0.58
284
2139
239
1788
1.63
6.79
13.3
7.5
0.00
0.00
e9/l
0.41
195
1457
161
1094
1.69
6.63
4.8
2.9
7.40
7.40
ph
0.19
46
182
115
719
1.77
6.35
4.5
2.0
2.45
2.43
mmol/l
0.98
107
613
122
777
1.75
6.32
2.4
2.2
5.21
6.96
e6/l
0.75
107
701
56
274
2.17
6.32
6.3
7.2
—
—
—
0
0
11
13
8.62
5.58
1.1
1.2
—
—
—
0
0
462
4195
2.04
5.53
17.8
11.3
27.55
21.40
mg/l
3.02
394
3179
147
1026
1.61
5.27
1.6
1.4
—
—
—
0
0
333
2788
1.56
5.27
3.4
2.9
58.28
44.53
u/l
1.20
312
2610
140
970
1.61
5.16
2.5
2.1
3.02
2.90
mg/l
0.26
126
806
56
302
1.96
4.89
5.0
6.1
1.51
1.34
mmol/l
0.58
56
296
60
334
1.90
4.77
3.6
3.3
—
—
—
0
0
332
2811
1.52
4.71
4.0
4.0
—
—
—
0
0
7
5
14.17
4.58
2.4
1.0
26.14
15.80
u/ml
—
7
5
82
512
1.72
4.48
3.0
2.1
128.33
105.79
ug/g
0.33
69
392
83
521
1.71
4.45
1.6
1.9
—
—
—
0
0
89
572
1.67
4.37
1.3
1.2
—
—
—
0
0
43
220
2.04
4.35
1.5
1.2
—
—
—
0
0
51
282
1.90
4.15
3.3
4.4
0.53
0.85
%
0.62
15
71
17
58
3.00
4.04
1.2
1.3
0.59
0.61
nmol/l
0.13
17
53
89
584
1.63
4.02
2.2
2.7
2.83
2.72
e6/l
0.04
44
304
48
265
1.90
3.93
1.2
1.4
—
—
—
0
0
468
4354
1.87
3.93
19.6
13.4
139.61
139.78
mmol/l
0.90
461
4230
469
4368
1.88
3.89
19.8
13.4
3.93
3.96
mmol/l
2.39
460
4237
356
3121
1.46
3.77
3.9
4.1
12.41
11.25
mm/h
0.77
336
2868
48
269
1.87
3.76
3.4
4.5
0.08
0.05
%
0.14
12
58
24
104
2.37
3.65
2.8
3.0
—
—
—
0
0
247
2036
1.41
3.63
4.5
4.8
0.00
0.00
estimate
-0.00
60
364
69
436
1.67
3.61
1.3
1.5
—
—
—
0
0
46
263
1.82
3.40
3.2
4.4
0.31
0.40
%
0.20
13
62
244
2035
1.38
3.22
3.4
3.5
0.00
0.01
estimate
0.74
58
391
14
49
2.91
3.21
1.4
1.3
—
—
nmol/l
—
0
0
15
55
2.78
3.18
1.3
1.3
—
—
—
0
0
152
1172
1.42
3.18
3.7
3.7
—
—
—
0
0
17
67
2.59
3.15
3.6
2.7
—
—
—
0
0
45
262
1.79
3.15
3.4
4.5
0.00
0.14
%
0.60
11
49
246
2066
1.37
3.06
3.4
3.5
0.00
0.01
estimate
0.50
59
356
140
1087
1.40
2.77
3.6
3.6
0.00
0.01
estimate
0.69
56
362
24
118
2.08
2.76
1.5
1.4
241.62
321.04
ug/g
0.96
17
68
142
1119
1.37
2.55
3.1
3.1
—
—
—
0
0
215
1806
1.33
2.53
3.5
2.7
94.82
106.65
ug/l
0.62
204
1654
59
393
1.57
2.53
1.8
2.1
1.86
1.73
%
0.53
48
346
10
32
3.17
2.44
1.1
1.6
—
—
—
0
0
16
71
2.29
2.36
3.2
3.0
2.10
3.12
mmol/l
—
10
46
52
343
1.57
2.33
4.6
3.1
2.28
2.16
mmol/l
0.07
41
279
466
4429
1.58
2.32
17.1
10.9
—
—
—
0
0
76
547
1.46
2.27
2.2
1.8
29.94
29.58
s
0.22
76
530
16
73
2.23
2.23
1.1
1.2
—
—
—
0
0
38
235
1.67
2.21
3.3
1.4
—
—
—
0
0
7
20
3.53
2.06
1.1
1.1
—
—
—
0
0
61
430
1.48
2.04
1.6
1.6
—
—
—
0
0
77
571
1.41
1.97
1.5
1.5
—
—
—
0
0
326
2957
1.28
1.96
4.4
3.6
—
—
—
0
0
6
16
3.78
1.94
1.0
1.4
—
—
—
0
0
113
895
1.34
1.93
1.8
1.6
0.86
0.92
mg/l
0.15
94
660
473
4538
1.56
1.92
13.6
8.5
27.29
26.01
u/l
0.91
462
4365
200
1713
1.27
1.91
2.1
2.0
90.10
96.93
pmol/l
1.35
120
840
29
175
1.70
1.87
4.9
2.1
0.70
0.64
%
0.44
29
175
183
1558
1.27
1.82
3.8
3.5
34.72
61.16
ng/l
0.55
125
1060
128
1046
1.30
1.75
2.2
2.2
7100.14
8107.12
umol/l
0.07
110
915
6
18
3.36
1.75
1.7
1.7
—
—
—
0
0
112
899
1.31
1.75
1.6
1.7
65591793.25
14987169.90
pmol/l
0.35
93
754
8
31
2.61
1.66
2.0
1.5
13.28
10.73
%
—
8
31
42
291
1.48
1.56
2.3
2.4
67.21
69.23
e9/l
0.13
27
221
12
57
2.13
1.56
1.0
1.0
23.21
6.72
u/ml
—
5
34
138
1156
1.27
1.54
3.5
2.9
1101.65
1174.22
ng/l
0.08
111
959
18
102
1.79
1.46
3.7
1.3
40.82
38.49
g/l
1.39
18
92
118
977
1.27
1.45
1.5
1.5
20.13
21.31
nmol/l
0.38
109
834
6
22
2.75
1.44
1.0
1.3
—
—
—
0
0
195
1712
1.22
1.42
2.7
2.3
74.50
77.92
nmol/l
0.90
177
1515
19
111
1.74
1.41
2.5
1.7
—
—
—
0
0
14
74
1.92
1.40
3.3
2.4
16.27
16.45
%
—
6
38
18
104
1.76
1.38
1.1
1.1
—
—
—
0
0
188
1649
1.22
1.37
3.3
3.2
6.19
5.88
ph
—
8
116
13
68
1.94
1.34
4.0
1.3
—
—
—
0
0
486
4732
1.53
1.32
26.4
16.8
40.20
40.45
%
0.51
463
4413
486
4733
1.53
1.31
26.5
16.8
257.26
252.42
e9/l
0.97
477
4612
12
62
1.96
1.28
1.4
1.4
—
—
—
0
0
486
4735
1.52
1.28
26.5
16.8
6.76
6.63
e9/l
0.72
476
4604
94
770
1.27
1.26
1.6
1.7
1284.36
1205.30
nmol/l
0.34
73
588
486
4736
1.52
1.26
26.5
16.8
4.47
4.52
e12/l
1.60
475
4602
23
147
1.59
1.25
1.5
1.2
—
—
—
0
0
6
25
2.42
1.24
1.0
1.1
—
—
—
0
0
12
63
1.93
1.23
1.2
1.1
0.67
2.44
u/ml
—
7
32
64
501
1.32
1.21
1.5
1.7
—
—
—
0
0
45
334
1.38
1.20
5.8
7.5
116.84
123.44
g/l
1.37
45
329
19
117
1.65
1.19
3.5
1.4
10.33
10.48
g/l
0.04
19
107
87
713
1.27
1.17
1.7
1.9
—
—
—
0
0
8
39
2.07
1.15
4.0
2.8
—
—
—
0
0
5
20
2.51
1.15
5.6
2.5
—
—
—
0
0
7
30
2.35
1.12
2.6
1.1
—
—
—
0
0
12
66
1.84
1.10
4.3
2.5
—
—
—
0
0
5
108
0.46
1.02
1.2
1.2
—
—
—
0
0
52
407
1.31
1.01
6.3
6.9
1.00
1.48
mmol/l
0.76
47
328
7
36
1.96
0.97
1.4
1.0
—
—
—
0
0
11
62
1.79
0.95
3.4
1.3
—
—
—
0
0
413
3969
1.21
0.94
4.9
4.7
1.86
2.19
mu/l
0.55
377
3647
20
134
1.51
0.93
1.5
1.1
—
—
—
0
0
13
78
1.68
0.92
4.1
3.3
60.77
58.68
%
0.24
13
78
13
78
1.68
0.92
3.8
3.0
4.65
4.43
e9/l
0.11
13
78
26
185
1.43
0.91
5.5
2.7
24.83
25.07
mmol/l
0.16
26
180
137
1214
1.18
0.86
2.6
3.0
—
—
—
0
0
23
162
1.44
0.86
8.3
4.1
—
—
—
0
0
25
179
1.42
0.86
6.8
8.7
24.63
24.64
mmol/l
0.01
25
173
13
80
1.64
0.85
2.2
2.4
—
—
—
0
0
51
409
1.27
0.85
1.4
1.4
—
—
—
0
0
11
65
1.71
0.83
1.9
2.8
—
—
—
0
0
8
46
1.75
0.83
1.6
1.8
93.04
89.93
%
—
8
46
30
224
1.36
0.82
1.5
1.7
—
—
—
0
0
24
173
1.41
0.80
5.8
9.6
—
—
—
0
0
0
25
0.00
0.79
0.0
1.5
—
11.20
—
0
25
8
48
1.68
0.79
1.3
1.2
—
—
—
0
0
174
1583
1.15
0.77
2.7
2.8
—
—
—
0
0
6
34
1.77
0.76
4.8
2.5
—
—
—
0
0
36
281
1.30
0.75
3.8
2.6
4.23
4.42
e9/l
0.12
30
231
15
100
1.52
0.73
5.0
3.9
—
—
—
0
0
21
286
0.72
0.72
2.3
2.7
—
—
—
0
0
7
41
1.72
0.70
1.7
2.4
—
—
—
0
0
20
144
1.40
0.69
1.7
2.1
589.54
276.36
ug/l
0.39
20
135
64
749
0.83
0.67
1.3
1.3
11.87
8.91
u/ml
0.10
26
270
7
43
1.64
0.67
2.0
1.9
32.29
33.88
pg
—
7
43
15
103
1.47
0.65
2.1
2.3
23.01
94.05
ug/min
—
8
62
10
62
1.63
0.65
1.3
2.3
—
—
—
0
0
39
316
1.25
0.63
4.5
3.4
143.59
180.03
ng/l
0.45
34
295
20
147
1.38
0.62
1.1
1.2
37.09
26.95
iu/l
0.45
15
124
11
71
1.56
0.62
1.5
1.4
—
—
—
0
0
5
30
1.67
0.61
3.6
2.5
—
—
—
0
0
22
165
1.35
0.61
1.2
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
161.38
—
0
22
0
22
0.00
0.59
0.0
15.4
—
1623.18
—
0
22
10
64
1.57
0.59
1.3
1.5
—
—
—
0
0
44
366
1.22
0.57
2.3
2.0
325.39
375.20
nmol/l
1.14
38
334
106
955
1.14
0.55
3.2
3.4
—
—
—
0
0
10
146
0.68
0.53
3.7
8.8
—
—
—
0
0
421
4306
0.87
0.52
4.3
4.5
4.64
4.70
mmol/l
0.50
397
4008
9
64
1.41
0.51
1.9
1.8
70.56
62.71
%
—
9
64
429
4377
0.88
0.48
4.9
5.0
2.68
2.78
mmol/l
1.56
404
4063
70
787
0.87
0.47
1.3
1.3
11.32
33.18
iu/ml
5.64
25
241
410
4002
1.12
0.46
6.0
5.7
39.49
39.70
mmol/mol
0.20
382
3730
7
50
1.41
0.45
1.9
2.2
—
—
—
0
0
7
51
1.38
0.44
1.9
2.2
3.67
4.03
mmol/l
—
7
51
7
51
1.38
0.44
1.9
2.2
108.00
105.49
mmol/l
—
7
51
6
95
0.63
0.42
1.5
1.3
0.67
1268.25
e6/l
—
6
76
6
95
0.63
0.42
1.5
1.2
9.50
4.82
e6/l
—
6
74
147
1372
1.10
0.42
2.9
3.1
7.80
7.41
mmol/l
0.45
123
1170
8
58
1.39
0.41
1.5
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
35
297
1.19
0.40
4.3
3.6
101.46
77.31
ng/l
0.65
29
266
0
18
0.00
0.40
0.0
1.5
—
28.75
—
0
12
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
9
66
1.37
0.38
1.0
1.3
—
—
—
0
0
22
179
1.24
0.38
1.5
1.8
—
—
—
0
0
25
207
1.22
0.37
2.7
2.4
—
—
—
0
0
5
37
1.35
0.37
2.0
1.6
0.36
0.47
nmol/l
—
5
32
5
77
0.65
0.36
2.2
1.6
—
—
—
0
0
420
4273
0.90
0.35
4.2
4.4
1.44
1.49
mmol/l
2.17
393
3967
33
283
1.18
0.35
1.2
1.2
—
—
—
0
0
11
145
0.75
0.35
3.6
3.5
24.81
24.75
mmol/l
0.03
11
137
46
407
1.14
0.34
1.4
1.5
—
—
—
0
0
27
317
0.84
0.33
1.2
1.2
157.20
139.72
iu/ml
—
10
125
135
1271
1.08
0.32
2.9
3.2
425.82
214.74
mg/l
0.21
86
792
8
66
1.22
0.27
1.0
1.1
—
—
—
0
0
5
72
0.69
0.26
1.0
2.0
0.85
0.97
g/l
—
5
54
37
330
1.13
0.26
3.4
3.1
—
—
—
0
0
36
321
1.13
0.25
1.6
1.4
—
—
—
0
0
6
81
0.74
0.24
1.2
1.2
—
—
—
0
0
16
189
0.84
0.22
1.2
1.1
—
147.00
titre
—
0
8
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
140
1340
1.06
0.22
3.5
3.8
3.75
8.41
mg/mmol
2.00
87
835
24
210
1.15
0.22
3.8
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
14.19
—
0
10
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
92
970
0.94
0.20
1.3
1.3
1.00
2.02
u/ml
1.00
24
258
90
949
0.94
0.20
3.7
3.6
1.02
1.02
kg/l
0.45
11
133
14
118
1.19
0.19
1.6
1.7
3.37
5.07
iu/l
—
6
40
13
109
1.20
0.18
1.2
1.2
—
—
—
0
0
16
183
0.87
0.16
1.1
1.1
—
—
—
0
0
21
187
1.13
0.16
1.2
1.7
—
14.68
—
0
5
40
430
0.92
0.15
1.3
1.3
—
—
—
0
0
15
171
0.87
0.15
1.0
1.2
—
0.99
—
0
12
62
588
1.06
0.14
2.5
2.5
0.68
0.70
ug/l
0.07
46
378
14
122
1.15
0.14
1.1
1.4
79.13
252.64
miu/ml
—
8
58
8
98
0.81
0.14
1.4
1.2
3.67
3.82
mmol/l
—
8
91
110
1063
1.04
0.13
4.8
3.6
1.85
1.85
ug/l
0.00
95
949
9
107
0.84
0.13
1.2
1.9
—
—
—
0
0
9
109
0.82
0.13
1.4
1.3
433.89
422.57
mg/l
—
9
100
15
169
0.88
0.13
3.8
3.2
—
—
—
0
0
22
200
1.10
0.12
1.1
1.1
—
—
—
0
0
37
346
1.07
0.12
1.1
1.2
—
—
—
0
0
408
4111
0.96
0.10
3.8
4.0
1.40
1.29
mmol/l
1.97
376
3785
5
46
1.09
0.09
3.4
2.8
—
—
—
0
0
26
243
1.07
0.09
5.8
4.8
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
425
4225
1.03
0.08
4.9
4.5
6.00
5.91
mmol/l
0.83
399
3862
7
66
1.06
0.08
1.0
1.1
—
—
—
0
0
7
67
1.05
0.08
1.0
1.1
—
—
—
0
0
6
75
0.80
0.07
2.2
1.6
—
—
—
0
0
8
76
1.05
0.07
1.4
1.7
—
—
—
0
0
7
81
0.86
0.07
1.7
1.4
—
—
—
0
0
7
80
0.87
0.07
1.6
1.4
—
—
—
0
0
7
83
0.84
0.07
1.9
1.5
—
—
—
0
0
116
1184
0.97
0.07
1.7
1.7
1.49
1.40
mmol/l
0.54
100
1001
11
122
0.90
0.07
1.8
1.5
—
—
—
0
0
12
110
1.09
0.05
1.2
1.7
27.67
38.80
nmol/l
2.39
12
105
47
482
0.97
0.03
2.0
1.4
—
—
—
0
0
16
151
1.06
0.03
1.6
1.6
—
—
—
0
0
16
151
1.06
0.03
1.6
1.6
—
—
—
0
0
26
269
0.96
0.02
1.5
1.4
—
—
—
0
0
80
789
1.02
0.02
3.5
4.0
27.83
344.86
ng/l
2.96
54
597
16
152
1.05
0.02
1.6
1.6
—
—
—
0
0
128
1269
1.01
0.02
2.0
2.2
124.34
181.52
u/l
3.31
123
1201
40
392
1.02
0.01
1.8
1.7
—
—
—
0
0
334
3331
1.01
0.01
4.4
4.0
14.73
14.77
pmol/l
0.09
304
3043
83
822
1.01
0.01
1.3
1.3
2.35
2.46
g/l
0.24
43
485
38
373
1.02
0.01
4.9
3.5
—
—
—
0
0
59
584
1.01
0.00
1.4
1.4
360.00
572.66
titre
0.93
12
139
14
145
0.96
0.00
5.4
5.0
0.93
0.92
%
0.03
14
139
15
146
1.03
0.00
5.1
5.0
1.61
1.60
%
0.02
15
140
11
113
0.97
0.00
1.7
2.4
—
—
—
0
0
12
123
0.98
0.00
1.3
1.1
—
—
—
0
0
38
375
1.01
0.00
2.8
2.4
8.69
6.94
ug/l
0.20
33
327
14
143
0.98
0.00
1.6
1.6
—
—
—
0
0
15
153
0.98
0.00
1.6
1.6
—
—
—
0
0
16
157
1.02
0.00
1.7
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
5.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
17.79
—
0
9
8
79
1.01
-0.00
2.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
8
79
1.01
-0.00
7.0
7.2
107.25
105.30
mmol/l
—
8
74
8
79
1.01
-0.00
7.0
7.2
10.13
11.03
mmol/l
—
8
74
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.98
—
0
5
0
8
0.00
-0.00
0.0
2.5
—
52.13
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
44.23
—
0
6
6
63
0.95
-0.00
1.2
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
5
59
0.85
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_COLORECTAL_NEUROENDO – Colorectal neuroendocrine tumor and carcinoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).