Selective deficiency of immunoglobulin A [IgA]y

D3_DEF_IIGA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D80.2
  • Hospital discharge: ICD-9 2790B
  • Cause of death: ICD-10 D80.2
  • Cause of death: ICD-9 2790B

2 out of 7 registries used, show all original rules.

161

4. Check minimum number of events

None

161

5. Include endpoints

None

161

6. Filter based on genotype QC (FinnGen only)

152

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Deficientia selectiva immunoglobulini A

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1030 548 479
Only index persons 873 467 406
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 23.14 26.92 18.74
Only index persons 27.90 32.01 23.16

-FinnGen-

Key figures

All Female Male
Number of individuals 152 94 58
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 38.91 37.24 41.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
161
Matched controls
1610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
190.9
143
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
33.5
31
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
24.6
23
*
2790B
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI A]
+∞
24.6
23
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
24.6
23
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
23.8
103
408
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
23.5
22
*
J01MA14
ATC
moxifloxacin; systemic
7.1
22.4
39
69
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.5
21.6
28
35
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
21.3
20
*
ZX120
NOMESCO Finland
Intravenous
6.3
21.1
42
85
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
20.3
61
177
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
18.9
20.3
31
20
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.4
18.5
35
67
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
18.2
70
243
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
16.7
44
113
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
16.6
59
192
J01MA12
ATC
levofloxacin; systemic
4.7
16.1
47
131
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
15.9
15
*
H02AB06
ATC
prednisolone; systemic
3.9
15.6
103
506
H02AB07
ATC
prednisone; oral
4.8
14.4
38
97
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.9
13.8
23
38
Z3231
NOMESCO Finland
Registered nurse
3.5
13.2
73
312
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.7
12.1
48
165
6BA02, ,
NOMESCO Finland
70.2
11.8
13
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.6
11.6
24
49
R03DC03
ATC
montelukast; oral
3.7
11.6
47
163
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.9
11.4
22
42
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
11.0
74
348
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.1
10.9
34
98
J47
ICD-10 Finland
Bronchiectasis
17.6
10.6
16
10
J45.9
ICD-10 Finland
Asthma, unspecified
3.4
10.4
48
180
R50.9
ICD-10 Finland
Fever, unspecified
3.5
10.1
42
147
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.3
10.1
22
47
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.5
10.1
21
43
K90.0
ICD-10 Finland
Coeliac disease
10.6
10.1
19
20
SPAT1262
SPAT
Handing over of treatment supplies
3.7
9.9
36
115
J01FA15
ATC
telithromycin; oral
4.2
9.7
28
76
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
13.5
9.6
16
13
WX892
NOMESCO Finland
Monitored bed care
4.9
9.4
22
50
P01BA02
ATC
hydroxychloroquine; oral
4.4
9.4
26
68
J01MA02
ATC
ciprofloxacin; systemic
2.8
9.3
72
360
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.9
9.2
30
89
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.8
9.2
19
24
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.4
9.1
25
65
M05BA04
ATC
alendronic acid; oral
7.4
9.0
21
32
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
8.8
24
62
Z3229
NOMESCO Finland
Other healthcare associate professional
4.6
8.8
22
53
J01FA06
ATC
roxithromycin; oral
2.7
8.7
79
425
J01FA01
ATC
erythromycin; systemic
3.3
8.3
37
134
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
8.3
47
196
L01BA01
ATC
methotrexate; systemic
9.7
8.3
16
18
J01FF01
ATC
clindamycin; systemic
2.8
8.2
57
266
C03CA01
ATC
furosemide; systemic
3.1
8.2
41
160
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
8.1
57
267
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.7
8.1
64
319
J01DA06
ATC
[U] cefuroxime
3.2
8.0
37
137
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.9
7.9
25
72
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
47.3
7.8
9
*
R05
ICD-10 Finland
Cough
2.9
7.7
45
191
WX002
NOMESCO Finland
Sedation and analgesia
3.1
7.6
37
141
L04AX03
ATC
methotrexate; systemic
3.7
7.6
26
79
Z2221
NOMESCO Finland
Medical doctor
2.6
7.5
63
321
A02BC02
ATC
pantoprazole; systemic
2.6
7.5
111
738
J01FA09
ATC
clarithromycin; systemic
2.5
7.4
68
361
L04AX01
ATC
azathioprine; systemic
4.9
7.4
17
38
R01AD05
ATC
budesonide; nasal
4.2
7.4
21
56
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
7.3
7
*
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
+∞
7.3
7
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
7.3
25
76
R03BA02
ATC
budesonide; inhalant
2.9
7.2
42
177
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.4
7.2
28
93
L04AA13
ATC
[U] leflunomide
10.8
7.2
13
13
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
8.1
7.1
15
20
Z3226
NOMESCO Finland
Physiotherapist
2.8
7.0
43
186
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.5
7.0
108
721
R01AD12
ATC
fluticasone furoate; nasal
2.4
6.9
70
387
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.4
6.9
27
90
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
6.8
22
64
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.0
6.7
20
55
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
6.7
67
367
WW200
NOMESCO Finland
Immunization
9.3
6.7
13
15
R03BA05
ATC
fluticasone; inhalant
2.7
6.7
46
211
GD1AD
NOMESCO Finland
Thorax CT examination
6.7
6.7
16
26
R03AC02
ATC
salbutamol; inhalant
2.4
6.6
107
722
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.4
6.5
109
744
L04AC07
ATC
tocilizumab; parenteral
72.6
6.5
7
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
11.7
6.4
11
10
L88
ICPC
Rheumatoid/seropositive arthritis
6.8
6.3
15
24
ZXA00
NOMESCO Finland
Right side
2.6
6.3
44
203
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
27.9
6.3
8
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
6.3
6
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.0
6.3
30
113
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.7
6.2
40
177
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
6.2
23
74
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
6.1
22
69
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.0
6.1
18
49
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
6.0
26
92

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
73
7.19
23.48
1.9
1.1
100.47
—
u/ml
—
12
0
47
98
6.36
23.01
1.6
1.2
154.39
352.63
u/ml
0.36
38
91
134
682
6.75
22.11
13.4
7.1
0.18
0.18
e9/l
0.07
129
610
92
349
4.82
22.06
2.8
1.4
1.04
2.26
g/l
5.49
23
213
131
665
6.21
21.35
13.3
6.8
0.04
0.04
e9/l
0.01
124
584
131
666
6.19
21.28
13.4
6.8
0.55
0.54
e9/l
0.14
124
585
125
625
5.47
20.35
12.7
7.5
—
—
—
0
0
24
6
46.53
20.14
1.8
1.2
13.83
8.83
%
—
24
6
132
693
6.02
20.11
13.2
6.7
1.84
1.91
e9/l
0.35
126
623
27
12
26.69
19.84
1.3
1.8
—
—
—
0
0
21
5
47.95
17.76
3.4
1.4
568.43
1023.00
u/ml
—
21
5
136
785
5.72
16.97
15.6
10.3
3.95
3.95
e9/l
0.01
128
684
94
468
3.42
13.30
7.5
5.2
36.82
36.60
g/l
0.15
86
453
101
527
3.46
13.20
11.2
8.3
1.21
1.21
mmol/l
0.18
87
461
15
5
32.81
11.87
2.1
1.2
24.53
26.60
%
—
15
5
69
303
3.24
11.71
6.8
4.3
7.39
7.40
ph
0.78
18
57
15
6
27.34
11.36
2.1
1.7
13.73
7.50
%
—
15
6
49
181
3.45
10.93
1.6
1.6
325.71
534.63
titre
0.72
14
41
44
154
3.56
10.65
2.2
2.3
—
—
—
0
0
61
266
3.08
10.26
7.7
4.3
—
—
—
0
0
34
104
3.88
9.98
3.5
3.5
1.90
1.61
%
1.29
29
99
27
72
4.30
9.52
3.0
2.8
70.09
70.17
e9/l
0.00
22
59
9
0
+∞
9.46
1.2
0.0
—
—
—
0
0
104
625
2.88
9.39
19.4
9.4
0.00
0.00
e9/l
0.50
91
507
71
352
2.82
9.28
5.1
2.6
—
—
—
0
0
30
91
3.82
8.87
4.9
6.2
0.69
0.64
%
—
8
28
32
102
3.67
8.81
4.6
6.5
0.90
0.67
%
—
10
36
22
53
4.65
8.77
2.5
4.2
—
—
—
0
0
39
143
3.28
8.64
11.8
7.7
1.09
1.10
mmol/l
0.11
39
133
68
341
2.72
8.56
13.0
7.7
—
—
—
0
0
39
145
3.23
8.43
1.9
1.6
—
—
—
0
0
55
250
2.82
8.34
5.8
2.8
515.58
564.13
mosm/kgh2o
0.76
50
218
37
138
3.18
7.93
1.8
1.5
—
—
—
0
0
17
23
8.13
7.91
1.6
1.0
—
—
—
0
0
68
355
2.58
7.75
5.5
2.6
0.17
0.38
e6/l
1.16
52
264
13
11
12.73
7.73
4.8
4.6
—
—
—
0
0
71
384
2.52
7.45
5.8
2.8
10.57
45.04
e6/l
1.97
56
294
79
460
2.41
6.93
6.2
3.4
119.73
28.02
e6/l
0.50
59
313
28
97
3.28
6.72
5.1
6.7
0.00
0.10
%
—
6
30
69
388
2.36
6.45
2.9
3.2
2.35
2.35
mmol/l
0.14
62
345
27
95
3.21
6.31
5.1
6.7
0.00
0.03
%
—
5
29
43
199
2.58
6.09
2.6
2.5
2.81
2.39
e6/l
0.11
19
100
45
215
2.52
5.96
2.2
1.5
—
—
—
0
0
63
359
2.24
5.55
2.5
2.0
—
—
—
0
0
35
158
2.55
5.16
2.0
1.6
1152.07
1172.10
nmol/l
0.04
30
119
81
522
2.11
5.13
3.7
2.9
5.69
5.75
ph
—
8
52
35
159
2.53
5.09
1.3
1.2
—
—
—
0
0
16
46
3.75
5.04
1.2
1.2
—
—
—
0
0
23
85
2.99
4.93
7.6
8.3
22.67
25.84
mmol/l
5.82
23
85
55
309
2.18
4.92
1.9
1.7
—
—
—
0
0
73
458
2.09
4.91
10.2
10.9
1.01
1.17
inr
3.75
21
149
9
10
9.45
4.85
2.3
1.2
—
—
—
0
0
15
35
4.62
4.77
1.6
1.3
—
—
—
0
0
68
420
2.07
4.73
2.3
1.8
89.94
96.72
pmol/l
0.60
39
211
118
895
2.19
4.66
7.5
3.8
—
—
—
0
0
9
11
8.59
4.62
2.1
1.5
—
—
—
0
0
52
293
2.14
4.58
2.0
2.1
1.30
0.83
mg/l
0.87
41
222
20
72
3.03
4.47
1.5
1.4
—
—
—
0
0
91
638
1.98
4.33
6.2
3.1
0.05
0.01
estimate
0.39
22
148
46
252
2.16
4.32
1.8
1.4
20.65
22.72
nmol/l
0.37
38
217
18
63
3.09
4.22
5.8
3.9
—
—
—
0
0
12
27
4.71
4.02
1.4
1.4
387.43
327.48
ug/g
—
7
13
12
28
4.54
3.91
3.5
2.7
—
—
—
0
0
9
15
6.28
3.87
2.8
11.6
—
—
—
0
0
89
642
1.86
3.67
7.9
4.4
0.00
0.00
estimate
-0.00
21
140
39
214
2.09
3.60
3.6
2.8
251.55
99.69
ug/g
1.41
31
170
61
392
1.90
3.60
5.0
3.3
283.45
37.83
ng/l
0.60
31
223
13
36
3.84
3.59
1.2
1.3
—
—
—
0
0
89
646
1.84
3.56
6.3
3.2
0.00
0.02
estimate
0.50
20
134
25
115
2.39
3.51
6.7
7.0
0.41
2.14
mmol/l
1.00
18
89
27
131
2.27
3.36
2.0
1.4
—
—
—
0
0
23
105
2.39
3.28
7.9
9.1
—
—
—
0
0
52
326
1.88
3.26
7.2
3.5
0.00
0.01
estimate
0.50
20
140
8
15
5.55
3.23
7.8
2.0
—
—
—
0
0
14
50
2.97
3.17
1.4
1.1
—
—
—
0
0
13
41
3.36
3.14
2.2
5.0
1.00
0.16
g/l
—
5
21
124
1023
1.92
3.06
5.4
3.8
14.71
14.52
pmol/l
0.39
117
941
39
227
1.95
3.03
1.3
1.3
10.43
26.24
iu/ml
—
9
76
11
32
3.61
2.96
6.3
4.5
61.45
55.09
%
0.75
11
32
11
32
3.61
2.96
6.2
3.8
4.97
3.90
e9/l
0.69
11
32
54
353
1.80
2.93
4.8
3.1
8.19
8.52
mmol/l
0.15
44
309
25
126
2.17
2.84
1.2
1.6
—
—
—
0
0
20
93
2.31
2.74
1.4
1.4
—
—
—
0
0
44
275
1.83
2.74
3.6
3.1
—
—
—
0
0
5
7
7.32
2.56
1.0
1.0
—
—
—
0
0
26
139
2.04
2.55
2.3
1.5
—
—
—
0
0
51
344
1.71
2.42
4.4
2.7
—
—
—
0
0
45
293
1.74
2.42
3.7
3.0
363.93
8393.70
umol/l
1.72
40
269
12
46
2.74
2.42
1.4
1.4
—
—
—
0
0
38
236
1.80
2.40
1.3
1.3
1.56
5.85
u/ml
1.04
20
99
55
380
1.68
2.39
3.0
2.2
—
—
—
0
0
104
850
1.63
2.27
4.3
3.0
—
—
—
0
0
30
177
1.85
2.22
2.8
3.0
2.44
2.44
mmol/l
0.13
24
161
7
19
3.80
2.17
1.3
1.1
—
—
—
0
0
24
133
1.95
2.14
1.3
1.2
—
—
—
0
0
8
25
3.31
2.12
1.0
1.1
—
—
—
0
0
65
482
1.58
2.09
2.3
1.9
—
—
—
0
0
40
263
1.69
2.06
4.0
3.2
1.02
1.02
kg/l
—
5
30
18
91
2.10
2.04
8.5
5.0
—
—
—
0
0
10
38
2.74
2.04
8.9
23.1
—
—
—
0
0
9
32
2.92
2.03
1.0
1.1
—
—
—
0
0
5
11
4.65
1.95
1.8
1.7
12.80
12.34
umol/l
—
5
11
5
11
4.65
1.95
1.2
1.6
—
—
—
0
0
52
376
1.57
1.82
7.6
2.8
—
—
—
0
0
16
82
2.06
1.76
1.8
1.1
—
—
—
0
0
6
18
3.42
1.76
2.0
3.1
—
—
—
0
0
26
158
1.77
1.76
1.3
1.2
—
—
—
0
0
7
24
3.00
1.74
2.4
2.2
—
—
—
0
0
41
284
1.60
1.71
4.8
3.2
109.38
64.25
mg/l
0.27
26
187
5
15
3.40
1.53
1.2
3.2
—
—
—
0
0
47
346
1.51
1.49
1.4
1.7
1.53
1.37
mmol/l
0.43
38
296
5
16
3.19
1.45
1.0
1.6
—
—
—
0
0
42
304
1.52
1.44
6.5
3.6
27.49
10.79
mg/mmol
0.35
30
192
21
129
1.72
1.38
7.9
8.6
105.76
104.17
mmol/l
1.04
21
129
42
552
0.68
1.36
4.3
2.4
—
—
—
0
0
14
76
1.92
1.34
3.6
3.9
—
—
—
0
0
6
24
2.56
1.31
3.5
3.0
4.88
5.17
kpa
—
6
24
6
24
2.56
1.31
2.2
9.8
—
—
—
0
0
6
24
2.56
1.31
3.7
3.0
9.25
9.24
kpa
—
6
24
6
25
2.45
1.25
2.0
2.2
—
—
—
0
0
10
49
2.11
1.25
4.0
2.1
—
—
—
0
0
5
19
2.68
1.22
2.2
9.3
71.20
69.96
%
—
5
19
6
26
2.36
1.20
1.3
1.9
—
—
—
0
0
5
112
0.43
1.18
1.2
1.4
—
—
—
0
0
16
96
1.74
1.15
1.4
1.2
—
33.85
—
0
8
11
58
1.96
1.15
8.9
10.3
92.57
94.15
%
0.29
11
58
5
21
2.42
1.10
2.8
2.4
1.04
1.80
mmol/l
—
5
21
5
21
2.42
1.10
1.2
1.5
—
—
—
0
0
5
21
2.42
1.10
2.0
2.0
—
—
—
0
0
5
22
2.31
1.04
3.0
1.4
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
13
76
1.77
1.02
1.2
1.2
—
—
—
0
0
9
49
1.89
1.00
1.2
1.1
—
—
—
0
0
18
117
1.61
0.99
10.9
3.4
—
—
—
0
0
5
23
2.21
0.98
6.4
1.7
—
—
—
0
0
11
62
1.83
0.97
6.9
7.4
118.00
129.24
g/l
0.69
11
62
10
55
1.87
0.94
2.4
6.5
0.69
0.68
%
—
10
55
13
203
0.61
0.92
1.1
1.4
—
—
—
0
0
6
29
2.11
0.90
1.7
2.3
—
—
—
0
0
10
56
1.84
0.90
2.5
6.4
1.94
1.58
%
—
10
56
12
74
1.67
0.80
1.9
1.6
276.67
317.45
mu/l
0.40
12
64
0
26
0.00
0.79
0.0
2.1
—
—
—
0
0
27
203
1.40
0.77
4.0
3.4
229.35
220.85
ng/l
0.01
17
130
6
34
1.79
0.77
1.0
1.1
—
—
—
0
0
5
27
1.88
0.69
1.0
1.2
—
—
—
0
0
11
70
1.61
0.67
6.9
2.2
—
—
—
0
0
5
29
1.75
0.64
1.2
1.1
—
—
—
0
0
5
29
1.75
0.64
1.2
1.1
—
—
—
0
0
8
49
1.67
0.63
6.9
3.4
—
—
—
0
0
34
275
1.30
0.62
3.5
3.9
1.26
1.68
ug/l
1.29
34
250
11
72
1.57
0.61
1.0
1.0
—
—
—
0
0
138
1317
1.33
0.59
5.0
4.1
2.70
2.85
mmol/l
1.10
132
1238
14
98
1.47
0.59
3.6
2.2
—
—
—
0
0
6
36
1.69
0.57
1.0
1.1
—
—
—
0
0
14
99
1.45
0.56
2.2
1.8
—
—
—
0
0
14
99
1.45
0.56
3.6
2.2
—
—
—
0
0
14
99
1.45
0.56
3.8
2.2
—
—
—
0
0
11
74
1.52
0.55
4.4
2.4
—
—
—
0
0
28
226
1.29
0.53
1.7
1.7
—
—
—
0
0
13
92
1.45
0.52
3.8
2.3
—
—
—
0
0
7
50
1.42
0.45
6.0
3.0
—
—
—
0
0
28
231
1.26
0.45
1.9
1.6
—
—
—
0
0
14
104
1.38
0.45
1.4
1.4
—
—
—
0
0
8
57
1.42
0.43
5.1
12.6
—
—
—
0
0
5
33
1.53
0.41
3.2
4.3
23.00
24.77
mmol/l
—
5
33
34
292
1.21
0.39
6.5
3.5
—
—
—
0
0
9
67
1.36
0.39
7.8
3.6
—
—
—
0
0
14
108
1.32
0.36
1.4
1.2
36.00
118.82
iu/ml
—
7
40
149
1454
1.33
0.36
24.8
10.2
—
—
—
0
0
7
53
1.34
0.31
1.0
1.3
—
—
—
0
0
134
1303
1.17
0.26
4.8
3.8
1.43
1.45
mmol/l
0.21
128
1221
5
42
1.20
0.21
5.4
7.3
—
—
—
0
0
19
164
1.18
0.21
2.7
2.7
0.64
0.72
ug/l
0.25
12
97
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
16.2
5.3
22.85
24.45
mmol/l
—
6
48
0
14
0.00
0.20
0.0
1.2
—
208.06
—
0
14
6
51
1.18
0.19
5.5
1.4
—
—
—
0
0
18
157
1.16
0.18
1.3
1.9
—
—
—
0
0
127
1241
1.11
0.17
4.7
3.7
5.89
5.76
mmol/l
0.51
120
1157
5
43
1.17
0.10
1.4
1.6
—
—
—
0
0
5
45
1.11
0.10
4.0
2.3
6.98
4.85
umol/l
—
5
34
112
1140
0.94
0.09
7.3
4.7
39.39
38.66
mmol/mol
0.28
107
1083
8
75
1.07
0.07
1.0
1.1
—
—
—
0
0
126
1246
1.05
0.06
4.5
3.5
1.31
1.28
mmol/l
0.18
120
1163
42
423
0.99
0.00
1.5
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
57.00
—
0
7
0
8
0.00
-0.00
0.0
1.8
—
1.50
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
9.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
12.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
84
0.95
-0.00
1.6
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
0.86
—
0
9

Mortality – FinRegistry

Association

Association between endpoint D3_DEF_IIGA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_DEF_IIGA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_DEF_IIGA – Selective deficiency of immunoglobulin A [IgA]y

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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