No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
155 |
4. Check minimum number of eventsNone |
155 |
5. Include endpointsNone |
155 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80
- Name in latin
- Deficientia selectiva immunoglobulini A
Similar endpoints
↥List of similar endpoints to
Selective deficiency of immunoglobulin A [IgA]y
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1030 | 548 | 479 |
| Only index persons | 873 | 467 | 406 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 23.14 | 26.92 | 18.74 |
| Only index persons | 27.90 | 32.01 | 23.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 94 | 61 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 39.16 | 37.72 | 41.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1459
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
175.6
131
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
30.3
28
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
23.6
22
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
22.5
21
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
22.5
21
*
2790B
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI A]
+∞
22.5
21
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
21.4
20
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.0
18.6
89
348
J01MA14
ATC
moxifloxacin; systemic
10.4
18.2
37
46
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
15.9
15
*
ZX120
NOMESCO Finland
Intravenous
7.4
15.8
40
71
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
14.1
15.3
26
22
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
11.2
14.2
27
29
H02AB06
ATC
prednisolone; systemic
3.8
13.4
90
431
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
13.3
61
211
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.5
13.1
54
168
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.9
12.4
32
57
R50.9
ICD-10 Finland
Fever, unspecified
5.1
11.7
40
101
J47
ICD-10 Finland
Bronchiectasis
22.2
11.4
16
8
6BA02
NOMESCO Finland
NA
47.2
11.1
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
11.0
48
154
J01MA12
ATC
levofloxacin; systemic
4.5
10.6
41
117
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.5
10.2
31
68
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
9.7
38
109
K90.0
ICD-10 Finland
Coeliac disease
13.6
9.6
16
13
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.1
9.3
17
17
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.4
9.2
52
202
M05BA04
ATC
alendronic acid; oral
7.8
8.9
20
29
J01FA06
ATC
roxithromycin; oral
2.9
8.6
75
389
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.8
8.5
15
14
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.6
8.3
41
144
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
5.3
8.2
25
55
P01BA02
ATC
hydroxychloroquine; oral
5.7
7.8
22
44
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.8
7.8
26
63
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.0
7.8
21
40
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.0
7.8
21
40
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
26.6
7.7
10
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.7
7.6
97
613
J45.9
ICD-10 Finland
Asthma, unspecified
3.3
7.5
41
154
J01FA09
ATC
clarithromycin; systemic
2.8
7.4
61
300
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
8.0
7.4
16
22
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
7.3
7
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.8
7.3
20
39
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.9
7.1
23
54
H02AB07
ATC
prednisone; oral
3.7
7.0
32
104
WX892
NOMESCO Finland
Monitored bed care
5.5
7.0
20
41
C03CA01
ATC
furosemide; systemic
3.4
7.0
35
123
TDM10
NOMESCO Finland
Puncture of maxillary antrum
10.1
6.9
13
14
R03BA05
ATC
fluticasone; inhalant
3.1
6.8
41
163
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.0
6.8
21
47
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
6.8
23
57
J01FA15
ATC
telithromycin; oral
4.1
6.8
26
73
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.5
6.7
23
58
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
6.6
46
203
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.1
6.5
17
31
R03AC02
ATC
salbutamol; inhalant
2.4
6.4
89
569
L04AA13
ATC
leflunomide; oral
9.9
6.4
12
13
J01MA02
ATC
ciprofloxacin; systemic
2.5
6.4
61
322
H04.10
ICD-10 Finland
Dry eye syndrome
4.4
6.3
22
56
J01FA01
ATC
erythromycin; systemic
3.3
6.3
34
124
R03DC03
ATC
montelukast; oral
3.0
6.3
38
151
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
J01DA06
ATC
[U] cefuroxime; systemic
3.2
6.2
34
126
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.4
6.2
90
584
J01AA02
ATC
doxycycline; systemic
2.6
6.2
112
814
R4110
NOMESCO Finland
Physiotherapy
2.7
6.1
48
225
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
93
6.82
24.44
1.6
1.2
154.4
371.1
u/ml
0.38
38
86
39
68
7.33
22.79
1.9
1.1
100.5
—
u/ml
—
12
0
19
13
16.52
21.43
1.6
1.5
943.6
850.6
e6/l
—
8
7
25
7
42.15
20.56
1.8
1.1
—
—
—
0
0
21
5
48.21
17.79
3.4
1.4
568.4
1023.0
u/ml
—
21
5
132
756
6.03
16.95
15.7
10.5
3.9
3.9
e9/l
0.08
124
657
98
513
3.48
12.77
11.0
8.5
1.2
1.2
mmol/l
0.24
84
443
90
455
3.33
12.28
7.2
5.3
36.8
36.6
g/l
0.15
82
439
95
501
3.32
11.98
3.5
2.4
75.7
74.4
nmol/l
0.21
89
453
15
5
32.93
11.88
2.1
1.2
24.5
26.6
%
—
15
5
14
5
30.52
10.93
1.0
1.0
—
—
—
0
0
14
5
30.52
10.93
1.0
1.0
94.0
81.6
%
—
14
5
27
70
4.46
9.90
2.9
1.6
—
—
—
0
0
45
168
3.37
9.82
2.3
1.7
—
—
—
0
0
76
418
2.61
7.87
5.4
3.0
—
—
—
0
0
36
139
3.07
7.27
11.7
7.9
1.1
1.1
mmol/l
0.18
36
129
64
338
2.52
7.05
5.6
2.7
0.2
0.4
e6/l
0.98
49
249
15
32
5.08
6.85
2.2
3.8
—
—
—
0
0
13
26
5.37
6.35
2.4
4.5
0.0
0.0
g/l
0.00
13
26
11
19
6.16
6.20
2.1
1.2
—
—
—
0
0
66
378
2.30
5.85
2.8
3.3
2.3
2.3
mmol/l
0.07
59
334
41
193
2.53
5.60
2.7
2.5
2.8
2.2
e6/l
0.16
19
97
29
115
2.87
5.52
2.5
1.5
—
—
—
0
0
14
34
4.43
5.49
1.2
1.3
—
—
—
0
0
13
31
4.49
5.20
1.7
1.3
—
—
—
0
0
13
31
4.49
5.20
1.7
1.3
—
—
—
0
0
41
200
2.43
5.16
2.7
2.3
0.7
0.9
e6/l
0.29
19
104
11
23
5.07
5.10
1.3
1.9
—
—
—
0
0
28
115
2.75
4.98
2.6
1.5
—
—
—
0
0
66
399
2.14
4.95
2.4
1.8
87.7
97.1
pmol/l
0.96
37
200
12
28
4.56
4.92
1.4
1.9
—
—
—
0
0
8
7
11.96
4.84
1.3
1.4
—
—
—
0
0
33
151
2.51
4.73
1.9
1.6
1160.1
1173.4
nmol/l
0.03
28
117
12
29
4.40
4.72
1.4
1.9
—
—
—
0
0
12
29
4.40
4.72
2.0
1.2
—
—
—
0
0
11
25
4.66
4.64
1.9
3.0
—
—
—
0
0
45
239
2.24
4.62
1.9
1.4
21.0
22.9
nmol/l
0.32
37
207
21
78
2.96
4.46
5.9
4.6
1.0
1.3
mmol/l
0.11
16
60
17
57
3.23
4.27
2.4
1.5
—
—
—
0
0
21
81
2.84
4.18
8.0
8.7
22.8
25.9
mmol/l
5.13
21
81
8
10
8.36
4.11
4.5
3.0
—
—
—
0
0
49
282
2.08
4.05
2.1
2.1
1.3
0.8
mg/l
0.70
38
217
15
48
3.35
4.05
1.2
1.3
—
—
—
0
0
87
613
1.96
4.04
6.1
3.1
0.0
0.0
estimate
0.00
19
132
10
25
4.21
3.76
1.2
1.2
—
1.1
—
0
11
10
25
4.21
3.76
2.6
4.5
0.0
0.0
g/l
—
10
25
10
25
4.21
3.76
2.6
4.5
0.0
0.0
g/l
—
10
25
15
51
3.15
3.69
1.1
1.1
—
—
—
0
0
10
26
4.04
3.58
1.9
2.2
—
—
—
0
0
13
42
3.29
3.46
1.3
1.3
—
—
—
0
0
85
616
1.84
3.43
7.9
4.4
0.0
0.0
estimate
0.00
19
132
7
10
7.27
3.40
4.1
2.2
—
—
—
0
0
137
1169
2.48
3.39
20.8
10.8
89.6
88.9
ml/min/173m2
0.10
124
933
15
54
2.97
3.36
2.0
1.4
—
—
—
0
0
85
620
1.82
3.32
6.2
3.2
0.0
0.0
estimate
0.50
18
126
15
55
2.91
3.26
1.7
1.3
—
—
—
0
0
8
15
5.56
3.23
2.5
1.7
—
—
—
0
0
120
981
1.99
3.20
5.5
3.8
14.7
14.5
pmol/l
0.33
113
906
24
114
2.31
3.15
6.1
7.1
0.8
2.2
mmol/l
0.75
17
87
38
217
2.00
3.14
1.3
1.3
10.4
27.0
iu/ml
—
9
72
57
373
1.84
3.14
5.1
3.4
301.8
38.6
ng/l
0.61
29
215
8
16
5.21
3.09
2.5
1.7
—
—
—
0
0
8
16
5.21
3.09
2.5
1.7
—
—
—
0
0
8
16
5.21
3.09
2.5
1.7
—
—
—
0
0
8
16
5.21
3.09
2.5
1.7
—
—
—
0
0
8
16
5.21
3.09
2.5
1.7
—
—
—
0
0
7
12
6.05
3.05
4.1
2.0
—
—
—
0
0
49
312
1.83
2.91
7.0
3.5
0.0
0.0
estimate
0.50
18
132
13
47
2.93
2.89
2.4
3.3
—
—
—
0
0
10
31
3.38
2.82
6.8
4.5
61.7
55.4
%
—
10
31
9
23
4.09
2.82
2.6
1.5
—
—
—
0
0
38
226
1.90
2.78
1.3
1.3
1.6
6.0
u/ml
1.04
20
95
5
6
8.56
2.77
1.4
2.2
—
—
—
0
0
5
6
8.56
2.77
1.4
2.2
—
—
—
0
0
5
6
8.56
2.77
1.4
2.2
—
—
—
0
0
23
115
2.17
2.68
3.1
1.8
—
—
—
0
0
14
56
2.65
2.61
1.1
1.3
—
—
—
0
0
8
20
4.16
2.60
1.5
1.5
—
—
—
0
0
42
266
1.79
2.51
3.0
2.3
—
—
—
0
0
7
16
4.53
2.50
1.3
1.3
—
—
—
0
0
8
21
3.96
2.50
1.4
2.1
—
—
—
0
0
65
469
1.66
2.43
6.7
3.2
—
—
—
0
0
5
8
6.41
2.39
1.4
2.0
—
—
—
0
0
5
8
6.41
2.39
1.4
2.0
—
—
—
0
0
5
8
6.41
2.39
1.4
2.0
—
—
—
0
0
5
8
6.41
2.39
1.4
2.0
—
—
—
0
0
7
17
4.26
2.39
1.1
2.1
—
—
—
0
0
7
17
4.26
2.39
1.1
1.2
—
—
—
0
0
12
47
2.68
2.33
2.3
4.2
92.0
96.7
%
0.42
12
47
6
13
4.75
2.29
2.8
1.0
—
—
—
0
0
9
29
3.23
2.26
3.4
1.5
—
—
—
0
0
5
9
5.70
2.23
1.4
1.9
—
—
—
0
0
43
285
1.70
2.17
3.4
3.1
356.9
6505.8
umol/l
1.55
38
260
6
14
4.41
2.17
1.2
1.9
—
—
—
0
0
6
14
4.41
2.17
2.8
1.1
—
—
—
0
0
51
357
1.64
2.09
1.9
1.8
—
—
—
0
0
29
173
1.83
2.08
2.9
3.1
2.4
2.4
mmol/l
0.22
23
157
5
10
5.12
2.08
1.0
1.2
—
—
—
0
0
25
142
1.91
2.08
3.2
1.9
—
—
—
0
0
11
45
2.55
1.98
1.8
2.0
—
—
—
0
0
5
11
4.66
1.95
1.4
2.0
—
—
—
0
0
5
11
4.66
1.95
1.4
2.0
—
—
—
0
0
5
11
4.66
1.95
1.4
2.0
—
—
—
0
0
6
16
3.86
1.95
1.2
1.9
—
—
—
0
0
5
13
3.94
1.73
1.0
1.2
—
—
—
0
0
5
13
3.94
1.73
1.8
1.2
—
—
—
0
0
10
43
2.42
1.64
3.1
1.8
—
—
—
0
0
5
14
3.65
1.63
1.4
2.3
—
—
—
0
0
18
101
1.88
1.57
5.4
3.1
—
—
—
0
0
46
335
1.53
1.55
1.4
1.6
1.5
1.4
mmol/l
0.41
37
287
117
1031
1.55
1.53
4.9
3.7
—
—
—
0
0
6
21
2.93
1.52
2.0
1.8
—
—
—
0
0
11
53
2.16
1.42
1.5
1.5
—
—
—
0
0
8
158
0.48
1.34
1.3
1.7
—
—
—
0
0
5
18
2.83
1.29
1.4
2.1
—
—
—
0
0
20
127
1.66
1.18
8.1
8.7
105.7
104.0
mmol/l
1.00
20
122
11
58
1.97
1.15
8.9
10.3
92.6
94.2
%
0.29
11
58
39
294
1.44
1.09
6.3
3.9
29.8
10.6
mg/mmol
0.37
27
185
68
566
1.36
1.07
4.6
4.1
—
—
—
0
0
9
47
1.97
1.04
1.2
1.1
—
—
—
0
0
0
30
0.00
0.98
0.0
1.4
—
—
—
0
0
9
51
1.81
0.96
13.6
4.7
55.5
55.9
%
—
9
51
27
199
1.43
0.86
4.0
3.4
229.4
222.6
ng/l
0.01
17
129
8
45
1.82
0.85
1.3
1.1
—
—
—
0
0
6
31
1.97
0.85
1.0
1.1
—
—
—
0
0
9
55
1.67
0.75
2.2
6.5
2.0
1.6
%
—
9
55
11
69
1.64
0.70
1.9
1.6
287.2
291.7
mu/l
0.04
11
60
135
1287
1.38
0.63
26.9
12.2
39.8
40.8
%
1.13
110
1061
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
7.7
—
0
15
33
269
1.29
0.58
3.4
3.7
1.3
1.6
ug/l
1.08
33
244
9
62
1.48
0.54
1.4
1.7
—
—
—
0
0
13
93
1.43
0.50
1.0
1.0
—
—
—
0
0
132
1270
1.27
0.43
5.0
4.1
2.7
2.8
mmol/l
0.88
126
1193
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
8
114
0.69
0.38
1.1
1.5
—
—
—
0
0
13
103
1.29
0.29
1.4
1.2
36.0
123.7
iu/ml
—
7
38
99
949
1.12
0.24
4.3
3.2
41.0
40.2
u/l
0.03
94
913
123
1194
1.15
0.24
4.6
3.7
5.9
5.8
mmol/l
0.52
116
1116
11
88
1.27
0.23
1.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.6
—
51.6
—
0
11
24
214
1.14
0.19
3.3
3.9
25.2
23.0
%
—
9
81
18
158
1.16
0.17
2.8
2.6
0.6
0.7
ug/l
0.17
12
93
128
1256
1.11
0.14
4.7
3.8
1.4
1.4
mmol/l
0.47
122
1177
27
252
1.09
0.10
3.1
2.2
—
—
—
0
0
5
48
1.04
0.09
13.4
5.3
23.0
24.5
mmol/l
—
5
48
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
23
245
0.93
0.07
2.0
1.5
—
—
—
0
0
108
1096
0.95
0.07
7.3
4.8
39.4
38.7
mmol/mol
0.27
103
1041
24
228
1.06
0.05
3.3
2.0
—
—
—
0
0
121
1200
1.04
0.03
4.5
3.5
1.3
1.3
mmol/l
0.21
115
1121
11
114
0.96
0.00
12.9
6.6
—
—
—
0
0
5
53
0.94
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
213.8
—
0
6
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_DEF_IIGA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_DEF_IIGA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_DEF_IIGA – Selective deficiency of immunoglobulin A [IgA]y
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data