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Nondiabetic hypoglycaemic coma

DOID Endpoint Browser PheWeb

E4_HYPOCOMA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E15
  • Hospital discharge: ICD-9 — 2510B
  • Cause of death: ICD-10 — E15
  • Cause of death: ICD-9 — 2510B

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

144

Control definitions (FinnGen only)

Control exclude
E4_GLUCOPANCREAS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E15-E16
Name in latin
Coma hypoglychaemicum non diabeticum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1177 513 627
Only index persons 618 283 335
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 46.88 50.02 44.06
Only index persons 34.95 33.91 35.83

-FinnGen-

Key figures

All Female Male
Number of individuals 144 69 75
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 24.84 25.86 23.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
145
Matched controls
1450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A10AA02, ,
ATC
124.3
182.4
105
30
A10AA01, ,
ATC
121.7
177.1
100
26
A10AB01
ATC
insulin (human); parenteral
112.5
174.6
101
29
A10AC01
ATC
insulin (human); parenteral
79.8
160.3
109
53
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
96.4
150.3
85
21
2510B
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[COMA HYPOGLYCAEMICUM]
+∞
142.0
112
*
H04AA01
ATC
glucagon; nasal, parenteral
79.2
134.3
78
21
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
51.4
125.6
86
40
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
66.5
124.4
75
23
A10AB05
ATC
insulin aspart; parenteral
46.8
123.8
90
49
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
74.9
115.3
66
16
A10AB04
ATC
insulin lispro; parenteral
51.1
113.6
74
29
A10AE04
ATC
insulin glargine; parenteral
35.8
110.4
92
67
T89
ICPC
Diabetes insulin dependent
35.8
92.7
67
34
103
Kela drug reimbursment
Diabetes, insulin-treated
34.7
89.5
123
201
A10AE05
ATC
insulin detemir; parenteral
34.0
86.7
63
32
215
Kela drug reimbursment
Diabetes, non-insulin-treated
18.9
73.0
102
162
E10
ICD-10 Finland
Type 1 diabetes mellitus
43.0
70.7
45
15
A10AE06
ATC
insulin degludec; parenteral
31.3
69.5
50
24
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
118.6
60.1
62
9
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
127.4
36.8
38
*
E15
ICD-10 Finland
Nondiabetic hypoglycaemic coma
+∞
35.9
33
*
SPAT1262
SPAT
Handing over of treatment supplies
8.6
34.2
58
104
H3600, E103,
ICD-10 Finland
87.9
31.5
34
5
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
+∞
31.4
29
*
XCK10
NOMESCO Finland
Photography of fundus of eye
10.2
29.1
38
49
A10AD01
ATC
insulin (human); parenteral
52.7
28.2
33
8
H3603, E103,
ICD-10 Finland
100.0
23.5
25
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
42.9
23.0
28
8
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
94.7
22.4
24
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
135.6
22.3
23
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
32.7
20.9
27
10
177
Kela drug reimbursment
Insulin glargine 300 U / ml
23.8
20.5
29
15
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
81.1
19.3
21
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
81.1
19.3
21
*
A10AA03, ,
ATC
36.7
17.6
22
7
H3601, E103,
ICD-10 Finland
40.5
17.2
21
6
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
4.7
17.2
54
162
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
51.0
15.5
18
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
51.0
15.5
18
*
H36.01
ICD-10 Finland
Diabetic maculopathy
51.0
15.5
18
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
89.4
14.9
16
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
30.9
14.7
19
7
A10AD04
ATC
insulin lispro; parenteral
+∞
13.8
13
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
153.8
13.7
14
*
CKC12
NOMESCO Finland
Photocoagulation of retina
12.8
13.1
23
21
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
19.6
12.9
19
11
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.6
12.9
16
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
12.7
42
128
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
141.8
12.6
13
*
171
Kela drug reimbursment
Degludekinsuliini
70.8
11.8
13
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.7
11.7
48
170
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
11.6
11
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
10.5
10
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
9.2
10.3
21
26
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
13.6
10.2
17
14
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.9
10.0
24
56
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
106.7
9.5
10
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
9.5
9
*
A10AB06
ATC
insulin glulisine; parenteral
39.3
9.2
11
*
OAB50, ,
SPAT
8.6
9.0
19
25
C10AA05
ATC
atorvastatin; oral
2.9
8.7
60
283
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.0
8.7
20
45
OAB50
NOMESCO Finland
Delivery of care equipment and instruction on their use
+∞
8.4
8
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
15.7
8.4
13
9
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
12.8
8.3
14
12
C10AA01
ATC
simvastatin; oral
2.8
8.0
57
271
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
26.6
7.7
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.0
7.4
16
22
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
16.9
7.4
11
7
H3603, E113,
ICD-10 Finland
+∞
7.3
7
*
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
+∞
7.3
7
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
7.3
7
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
7.2
28
93
V03AE01
ATC
polystyrene sulfonate; oral
31.7
7.2
9
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.9
7.2
12
10
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
12.9
7.2
12
10
C10AX09
ATC
ezetimibe; oral
3.4
7.2
29
99
A11CC03
ATC
alfacalcidol; systemic
14.7
7.0
11
8
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
10.1
6.9
13
14
C03CA01
ATC
furosemide; systemic
2.8
6.9
45
203
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
23.8
6.8
9
*
R11
ICD-10 Finland
Nausea and vomiting
4.1
6.7
20
55
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
10.8
6.7
12
12
H26.4
ICD-10 Finland
After-cataract
4.5
6.6
17
42
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.8
6.5
13
16
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
72.9
6.5
7
*
BEF00, ,
SPAT
72.9
6.5
7
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
72.9
6.5
7
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
5.6
6.4
18
36
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.8
6.4
11
10
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
19.0
6.3
9
5
B05DA
ATC
Isotonic solutions
28.0
6.3
8
*
E10.0
ICD-10 Finland
Type 1 diabetes mellitus, With coma
+∞
6.3
6
*
WZC30
NOMESCO Finland
Teaching
3.0
6.2
31
120
205
Kela drug reimbursment
Chronic hypertension
2.7
6.0
38
167

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
94
256
8.60
37.81
7.9
4.0
16.96
11.95
mg/mmol
0.29
70
177
89
247
7.74
34.47
6.8
3.2
671.60
86.04
mg/l
0.47
66
173
93
299
6.88
29.90
6.4
3.1
7.02
7.99
mmol/l
1.20
82
264
31
77
4.85
12.12
6.2
3.6
5.86
5.79
kpa
0.11
31
77
21
40
5.97
10.95
7.0
4.0
25.13
24.36
mmol/l
0.39
21
40
61
264
3.26
10.66
2.0
1.3
6.79
1.11
u/ml
0.57
17
69
22
48
5.22
9.91
4.0
3.9
127.36
132.85
g/l
0.41
22
48
25
61
4.74
9.90
3.9
2.7
4.36
4.77
kpa
0.34
25
61
19
21
10.23
9.88
2.8
2.0
104.82
136.69
ug/min
—
14
9
54
274
2.55
6.48
2.4
1.7
1.20
1.39
mmol/l
0.89
48
243
16
42
4.16
5.71
2.6
2.4
1.71
1.62
%
0.06
16
42
16
42
4.16
5.71
2.6
2.4
0.83
0.65
%
1.07
16
42
21
76
3.06
4.68
12.1
7.6
—
—
—
0
0
36
184
2.27
4.04
2.1
1.6
481.81
474.74
pmol/l
0.05
27
157
9
15
6.32
3.88
4.0
2.9
1.13
1.53
mmol/l
—
9
15
22
92
2.64
3.78
1.3
1.2
—
—
—
0
0
81
1027
0.52
3.56
4.6
3.9
8.45
5.84
mmol/l
8.99
72
955
8
14
5.98
3.39
4.4
3.1
9.78
7.34
mmol/l
—
8
14
11
28
4.16
3.37
2.7
23.8
1.36
1.59
%
0.51
11
23
67
463
1.83
3.15
18.4
8.2
1.21
1.22
mmol/l
0.64
58
399
10
25
4.22
3.15
3.0
2.8
23.80
24.03
mmol/l
—
10
25
23
108
2.34
3.11
8.9
7.6
102.83
104.22
mmol/l
0.55
23
108
82
607
1.81
3.04
8.8
5.1
9.58
6.55
mmol/l
8.40
76
557
9
22
4.29
2.93
4.7
4.8
—
—
—
0
0
7
13
5.60
2.90
2.0
1.9
—
—
—
0
0
43
266
1.88
2.83
7.9
4.4
—
—
—
0
0
25
128
2.15
2.76
2.3
1.5
—
—
—
0
0
6
11
5.64
2.57
2.7
2.9
4.07
4.07
mmol/l
—
6
11
6
11
5.64
2.57
2.7
2.9
105.33
107.91
mmol/l
—
6
11
6
11
5.64
2.57
2.7
2.9
—
—
—
0
0
65
467
1.71
2.54
14.4
9.6
0.00
0.00
e9/l
-0.00
53
381
18
83
2.33
2.53
1.2
1.2
196.53
128.33
iu/ml
—
9
36
11
38
3.05
2.47
4.8
3.7
—
—
—
0
0
11
40
2.89
2.33
4.2
3.1
23.58
24.53
mmol/l
0.21
11
40
97
787
1.70
2.33
5.4
3.7
15.03
14.78
pmol/l
0.35
86
731
114
969
1.83
2.30
7.0
4.3
1.93
1.83
mu/l
0.46
107
898
38
247
1.73
2.08
1.6
1.5
3.69
2.35
g/l
0.44
22
164
6
15
4.12
2.06
4.3
3.4
—
—
—
0
0
58
429
1.59
1.91
8.3
10.8
1.14
1.19
inr
0.20
22
122
7
22
3.29
1.90
13.4
5.3
—
—
—
0
0
8
28
2.96
1.89
2.5
22.0
1.23
1.15
mmol/l
—
8
23
39
262
1.67
1.88
3.5
2.6
—
—
—
0
0
7
23
3.14
1.82
4.1
2.8
8.83
8.72
kpa
—
7
23
7
24
3.01
1.74
2.3
1.3
—
—
—
0
0
19
105
1.93
1.73
8.3
12.3
2.27
1.75
mmol/l
0.14
13
82
5
14
3.66
1.63
1.2
1.9
29.80
32.57
pg
—
5
14
6
22
2.80
1.45
10.3
5.6
—
—
—
0
0
5
115
0.41
1.32
2.6
1.4
—
—
—
0
0
24
156
1.65
1.31
3.8
2.2
—
—
—
0
0
9
167
0.51
1.29
1.2
1.3
—
—
—
0
0
15
85
1.85
1.28
2.2
4.0
1.00
0.63
%
—
8
30
46
351
1.45
1.24
3.7
3.4
32.37
21.65
ng/l
0.88
34
209
22
324
0.62
1.23
2.8
4.3
1.02
1.76
ug/l
4.33
22
286
5
19
2.69
1.22
2.4
3.4
—
—
—
0
0
46
352
1.45
1.22
2.1
2.0
109.16
94.02
pmol/l
1.02
24
187
8
39
2.11
1.17
2.1
1.4
—
—
—
0
0
120
1099
1.53
1.13
27.8
13.8
138.46
139.70
mmol/l
6.14
115
1072
21
138
1.61
1.10
1.4
1.5
—
—
—
0
0
5
21
2.43
1.10
1.0
1.1
—
—
—
0
0
36
268
1.46
1.09
5.3
3.4
—
—
—
0
0
42
323
1.42
1.07
2.7
2.3
—
—
—
0
0
120
1106
1.49
1.02
29.4
13.8
4.04
3.95
mmol/l
2.76
115
1079
15
93
1.68
0.98
2.2
4.2
1.50
0.75
%
—
8
36
37
283
1.41
0.97
12.6
4.5
7.39
7.40
ph
—
10
54
36
275
1.41
0.95
4.6
2.9
0.27
0.32
e6/l
0.13
27
206
14
86
1.70
0.95
2.2
4.3
0.29
0.14
%
—
7
28
13
80
1.69
0.88
2.6
3.0
0.18
0.22
g/l
0.86
13
75
121
1276
0.69
0.83
34.0
18.1
39.25
41.10
%
2.00
111
1211
39
309
1.36
0.83
5.9
3.0
9.48
31.83
e6/l
1.22
32
243
13
82
1.64
0.81
13.1
4.8
—
—
—
0
0
0
25
0.00
0.80
0.0
1.0
—
—
—
0
0
13
84
1.60
0.75
2.0
4.3
0.00
0.38
%
—
6
26
7
116
0.58
0.71
1.4
1.4
—
—
—
0
0
5
26
1.96
0.71
1.0
1.3
310.40
60.29
pmol/l
—
5
26
7
41
1.74
0.71
8.3
5.3
—
—
—
0
0
10
61
1.69
0.70
2.3
12.6
—
—
—
0
0
7
42
1.70
0.69
5.1
3.1
—
—
—
0
0
0
20
0.00
0.61
0.0
2.5
—
5.19
—
0
13
33
270
1.29
0.57
4.6
2.8
—
—
—
0
0
6
37
1.65
0.56
1.3
1.2
—
—
—
0
0
17
126
1.40
0.54
1.3
1.2
—
—
—
0
0
42
358
1.24
0.52
6.4
3.5
87.36
92.47
e6/l
0.03
33
255
48
417
1.23
0.50
4.1
3.2
—
5.78
—
0
37
7
45
1.58
0.49
17.4
19.6
—
—
—
0
0
79
724
1.20
0.47
4.4
3.4
—
—
—
0
0
114
1190
0.80
0.44
22.6
11.1
—
—
—
0
0
20
159
1.30
0.43
3.5
2.8
0.92
2.33
e6/l
—
10
85
5
32
1.58
0.42
1.0
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
37.56
—
0
15
0
15
0.00
0.41
0.0
1.7
—
243.20
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
27
226
1.24
0.39
1.4
1.8
0.74
0.89
mg/l
0.35
21
172
12
91
1.35
0.35
7.8
3.5
—
—
—
0
0
75
801
0.87
0.33
6.0
3.7
18.04
9.07
mm/h
2.28
67
755
61
560
1.15
0.33
6.5
6.1
10.03
10.51
umol/l
0.20
56
534
56
511
1.16
0.33
5.1
3.4
0.00
0.00
estimate
—
7
96
55
502
1.15
0.32
7.0
4.6
0.00
0.00
estimate
-0.00
11
101
39
436
0.86
0.32
1.8
1.9
—
—
—
0
0
19
157
1.24
0.31
1.4
1.5
493.33
433.94
titre
—
6
33
7
54
1.31
0.31
3.4
2.0
—
—
—
0
0
7
54
1.31
0.31
1.1
1.8
—
—
—
0
0
109
1130
0.86
0.29
25.5
12.3
32.63
22.81
mg/l
1.35
91
843
27
307
0.85
0.27
1.4
1.4
—
—
—
0
0
8
67
1.21
0.27
1.1
1.7
—
—
—
0
0
5
71
0.69
0.27
1.2
1.3
21.20
160.12
u/ml
—
5
63
10
78
1.30
0.25
1.3
1.7
1.14
1.06
g/l
—
10
72
5
40
1.26
0.22
1.0
1.3
—
—
—
0
0
10
124
0.79
0.22
1.1
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
3.7
—
51.67
—
0
6
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
11.8
—
0.63
—
0
10
0
10
0.00
0.21
0.0
1.6
—
14.01
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
3.0
—
—
—
0
0
0
14
0.00
0.20
0.0
6.0
—
—
—
0
0
11
90
1.24
0.20
1.3
1.4
—
—
—
0
0
20
227
0.86
0.20
4.3
3.5
—
—
—
0
0
17
195
0.85
0.19
2.4
1.6
—
—
—
0
0
25
277
0.88
0.18
7.6
7.7
—
—
—
0
0
9
79
1.15
0.15
4.4
3.5
—
—
—
0
0
13
149
0.86
0.14
1.4
1.5
—
—
—
0
0
28
259
1.10
0.13
5.6
2.9
318.32
4337.00
umol/l
1.07
28
228
14
125
1.13
0.10
2.1
2.9
4.62
8.06
umol/l
—
9
105
32
301
1.08
0.10
5.8
2.8
—
—
—
0
0
34
323
1.07
0.08
8.2
3.4
2.35
2.36
mmol/l
0.02
34
295
5
62
0.80
0.08
1.4
1.7
51.40
33.97
nmol/l
—
5
62
8
74
1.09
0.07
1.1
1.4
—
—
—
0
0
8
74
1.09
0.07
1.1
1.6
—
—
—
0
0
8
74
1.09
0.07
1.1
1.6
—
—
—
0
0
8
75
1.07
0.07
1.1
1.6
—
—
—
0
0
53
513
1.05
0.07
5.3
3.3
0.00
0.00
estimate
-0.00
12
106
64
656
0.96
0.06
6.2
3.9
—
54.20
—
0
10
49
505
0.96
0.06
6.5
6.3
62.88
56.92
%
2.75
44
484
20
188
1.07
0.06
1.3
1.3
9.20
28.67
iu/ml
—
5
66
17
181
0.93
0.05
1.4
1.3
23.45
7.77
u/ml
—
6
84
51
523
0.96
0.05
6.8
6.9
—
—
—
0
0
70
713
0.96
0.04
7.8
3.9
—
—
—
0
0
47
460
1.03
0.03
5.2
2.5
—
—
—
0
0
22
229
0.95
0.03
2.1
1.7
—
—
—
0
0
15
142
1.06
0.02
1.2
1.2
—
—
—
0
0
55
557
0.98
0.01
6.3
6.4
1.62
1.85
e9/l
1.69
50
511
57
563
1.02
0.01
6.1
6.6
0.19
0.19
e9/l
0.01
51
513
64
647
0.98
0.01
9.8
10.0
4.34
4.16
e9/l
0.30
59
576
106
1066
0.98
0.00
6.6
3.6
1.15
1.35
mmol/l
1.72
98
994
28
281
1.00
0.00
2.6
2.0
—
—
—
0
0
50
501
1.00
0.00
7.6
6.8
7.74
8.46
%
1.12
45
479
28
275
1.02
0.00
6.1
3.6
0.00
0.01
estimate
—
7
101
51
513
0.99
0.00
6.9
6.5
22.48
28.44
%
3.49
46
490
110
1105
0.98
0.00
7.7
4.0
4.32
4.70
mmol/l
4.45
104
1039
54
543
0.99
0.00
6.4
6.4
0.05
0.04
e9/l
1.60
48
489
14
135
1.04
0.00
2.8
1.8
—
—
—
0
0
54
544
0.99
0.00
6.4
6.4
0.53
0.57
e9/l
0.74
48
490
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
8.90
—
0
6
5
51
0.98
0.00
1.2
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
132.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
88.67
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
110
1100
1.00
-0.00
7.5
3.9
1.59
1.41
mmol/l
3.76
103
1030
0
7
0.00
-0.00
0.0
1.3
—
38.67
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
29.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
159.13
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
6
61
0.98
-0.00
1.7
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPOCOMA and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_HYPOCOMA 4.588 [1.64, 12.87] 0.004
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 143 males with E4_HYPOCOMA died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPOCOMA.

N-year risk Females Males
1 No data 0.841%
5 No data 5.63%
10 No data 13.552%
15 No data 23.531%
20 No data 36.266%

Relationships between endpoints

↥

Index endpoint: E4_HYPOCOMA – Nondiabetic hypoglycaemic coma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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