No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
144 |
Control definitions (FinnGen only)
- Control exclude
- E4_GLUCOPANCREAS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E15-E16
- Name in latin
- Coma hypoglychaemicum non diabeticum
Similar endpoints
↥List of similar endpoints to
Nondiabetic hypoglycaemic coma
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1177 | 513 | 627 |
| Only index persons | 618 | 283 | 335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.88 | 50.02 | 44.06 |
| Only index persons | 34.95 | 33.91 | 35.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 144 | 69 | 75 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 24.84 | 25.86 | 23.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 137
- Matched controls
- 1369
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
2510B
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[COMA HYPOGLYCAEMICUM]
+∞
142.9
111
*
A10AA02
ATC
NA
167.7
104.1
103
24
A10AA01
ATC
NA
175.6
100.4
98
19
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
138.2
97.5
99
25
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
93.1
94.6
106
48
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
124.4
82.2
84
17
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
69.9
74.6
85
31
103
Kela drug reimbursment
Diabetes, insulin-treated
46.2
73.6
120
181
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
53.3
71.1
87
43
A10AE04
ATC
insulin glargine; parenteral
48.2
71.0
90
52
H04AA01
ATC
glucagon; nasal, parenteral
87.9
70.4
76
19
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
101.9
69.4
73
15
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
63.5
63.6
73
24
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
63.7
57.0
65
19
T89
ICPC
Diabetes insulin dependent
53.3
54.0
64
22
215
Kela drug reimbursment
Diabetes, non-insulin-treated
21.0
53.5
99
151
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
70.5
52.0
58
14
A10AE05
ATC
insulin detemir; parenteral
32.4
44.6
60
32
E10
ICD-10 Finland
Type 1 diabetes mellitus
49.6
35.4
42
12
A10AE06
ATC
insulin degludec; parenteral
36.5
35.2
45
18
H3600, E103
ICD-10 Finland
NA
86.0
30.5
33
5
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
61.4
29.0
33
7
E15
ICD-10 Finland
Nondiabetic hypoglycaemic coma
+∞
28.1
26
*
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
317.9
26.7
26
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
41.2
26.0
32
10
177
Kela drug reimbursment
Insulin glargine 300 U / ml
69.6
25.1
28
5
H3603, E103
ICD-10 Finland
NA
57.6
20.9
24
5
SPAT1262
SPAT
Handing over of treatment supplies
8.0
20.8
53
100
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
45.6
19.3
23
6
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
39.0
18.7
23
7
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
61.4
18.5
21
*
XCK10
NOMESCO Finland
Photography of fundus of eye
11.0
18.2
36
43
A10AA03
ATC
NA
40.9
17.2
21
6
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
23.9
17.1
24
12
H3601, E103
ICD-10 Finland
NA
54.7
16.5
19
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
179.7
15.8
16
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
41.0
14.9
18
5
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
59.9
14.1
16
*
CKC12
NOMESCO Finland
Photocoagulation of retina
15.1
14.0
23
18
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
4.5
12.5
51
158
H36.00
ICD-10 Finland
Diabetic background retinopathy
24.0
12.4
17
8
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
13.5
12.3
21
18
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
51.6
12.1
14
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.7
12.1
46
132
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
33.4
11.9
15
5
171
Kela drug reimbursment
Degludekinsuliini
71.2
11.8
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
11.2
40
107
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
47.5
11.1
13
*
A10AB06
ATC
insulin glulisine; parenteral
118.7
10.6
11
*
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
35.6
10.5
13
*
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
14.7
10.5
17
13
H43.1
ICD-10 Finland
Vitreous haemorrhage
16.6
9.8
15
10
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
9.5
9
*
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
53.5
8.8
10
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
17.8
8.7
13
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.8
8.7
13
8
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.8
8.5
24
48
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
35.7
8.2
10
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
23.7
8.2
11
5
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
16.3
7.9
12
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
19.7
7.7
11
6
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
26.7
7.7
10
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
84.5
7.5
8
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
7.4
7
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
7.4
7
*
B05DA
ATC
Isotonic solutions
+∞
7.4
7
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
7.4
7
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
21.4
7.2
10
5
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
31.9
7.2
9
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.0
7.0
14
17
H36.01
ICD-10 Finland
Diabetic maculopathy
15.3
6.5
10
7
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
73.1
6.5
7
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
11.8
6.4
11
10
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
11.8
6.4
11
10
C10AA01
ATC
simvastatin; oral
2.7
6.4
53
260
Z49.2
ICD-10 Finland
Other dialysis
+∞
6.3
6
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.0
6.0
14
22
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
94
255
8.74
38.06
8.4
4.3
17.0
12.0
mg/mmol
0.29
70
177
19
21
10.27
15.91
2.9
2.1
104.8
136.7
ug/min
—
14
9
31
77
4.86
12.13
6.2
3.6
5.9
5.8
kpa
0.11
31
77
21
40
5.98
10.96
7.0
4.0
25.1
24.4
mmol/l
0.39
21
40
61
264
3.27
10.68
2.0
1.3
6.8
1.1
u/ml
0.57
17
69
22
48
5.23
9.91
4.0
3.9
127.4
132.9
g/l
0.41
22
48
17
38
4.94
7.40
6.8
3.4
42.0
56.9
%
1.06
17
38
53
274
2.48
6.06
2.4
1.7
1.2
1.4
mmol/l
0.82
47
243
16
42
4.16
5.71
2.6
2.4
1.7
1.6
%
0.06
16
42
36
183
2.29
4.10
2.1
1.6
481.8
476.9
pmol/l
0.04
27
156
16
55
3.15
3.88
4.3
3.5
1.8
1.2
mmol/l
0.60
11
41
80
1019
0.52
3.63
4.6
3.9
8.5
5.8
mmol/l
9.02
71
947
66
461
1.80
2.96
18.6
8.2
1.2
1.2
mmol/l
0.54
57
396
81
603
1.78
2.91
8.9
5.1
9.6
6.5
mmol/l
8.46
75
553
10
31
3.39
2.83
1.1
1.0
—
7.6
—
0
5
68
870
0.59
2.54
3.8
3.4
—
—
—
0
0
18
83
2.34
2.53
1.2
1.2
196.5
128.3
iu/ml
—
9
36
5
151
0.31
2.31
2.2
1.8
—
—
—
0
0
113
960
1.82
2.29
6.9
4.3
1.9
1.8
mu/l
0.42
106
889
96
782
1.68
2.23
5.4
3.7
15.1
14.8
pmol/l
0.39
85
726
7
21
3.45
1.99
6.3
8.3
—
5328.0
—
0
5
16
80
2.13
1.88
8.9
6.4
1.2
1.5
mmol/l
0.88
16
75
14
255
0.50
1.69
2.5
4.1
24.2
22.5
%
—
7
106
7
26
2.78
1.60
1.6
1.2
—
—
—
0
0
55
416
1.52
1.59
4.0
2.5
78.3
75.5
nmol/l
0.26
48
382
34
234
1.59
1.48
2.6
2.4
—
—
—
0
0
18
104
1.84
1.45
8.6
12.4
3.2
1.8
mmol/l
—
10
80
9
40
2.33
1.43
2.7
2.7
—
—
—
0
0
7
29
2.48
1.41
1.3
2.3
—
—
—
0
0
0
38
0.00
1.36
0.0
1.3
—
—
—
0
0
21
320
0.60
1.36
2.9
4.3
1.0
1.8
ug/l
3.98
21
282
8
37
2.23
1.23
2.4
2.4
—
—
—
0
0
0
36
0.00
1.15
0.0
1.5
—
—
—
0
0
45
349
1.42
1.10
3.7
3.4
32.4
21.7
ng/l
0.88
34
206
45
349
1.42
1.10
2.1
2.0
109.2
94.3
pmol/l
0.94
23
185
119
1092
1.52
1.08
27.8
13.8
138.4
139.7
mmol/l
6.30
114
1065
119
1099
1.48
0.97
29.4
13.8
4.0
4.0
mmol/l
2.94
114
1072
9
52
1.78
0.94
2.4
1.4
—
—
—
0
0
35
274
1.37
0.80
4.7
2.9
0.3
0.3
e6/l
0.13
27
205
0
25
0.00
0.80
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.1
—
—
—
0
0
5
24
2.12
0.75
2.8
1.4
—
—
—
0
0
11
68
1.67
0.74
2.2
1.6
—
—
—
0
0
14
93
1.56
0.72
2.9
3.4
—
—
—
0
0
5
26
1.96
0.71
1.0
1.3
310.4
60.3
pmol/l
—
5
26
5
27
1.88
0.69
1.0
1.1
—
—
—
0
0
12
80
1.55
0.62
2.8
3.0
0.2
0.2
g/l
0.60
12
75
5
30
1.69
0.62
1.8
1.9
—
—
—
0
0
5
30
1.69
0.62
2.2
2.8
262.8
185.4
%
—
5
30
0
20
0.00
0.61
0.0
1.3
—
9.0
—
0
9
8
53
1.54
0.59
2.1
1.6
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
22
169
1.36
0.57
3.5
2.6
5.1
0.8
e6/l
0.41
13
95
107
1011
1.23
0.45
19.0
11.1
84.4
89.2
ml/min/173m2
1.10
100
825
41
356
1.21
0.43
6.9
3.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
15
192
0.76
0.41
1.9
2.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
7.9
—
0
11
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
8
113
0.69
0.39
7.6
8.6
—
—
—
0
0
5
36
1.40
0.38
1.2
3.1
—
—
—
0
0
56
508
1.17
0.36
5.1
3.3
0.0
0.0
estimate
—
7
96
13
166
0.76
0.35
1.7
2.0
1.7
1.4
%
1.55
13
155
55
499
1.17
0.35
7.0
4.6
0.0
0.0
estimate
0.00
11
101
108
1122
0.85
0.31
25.6
12.4
32.8
22.8
mg/l
1.37
90
836
19
158
1.23
0.30
3.6
2.8
0.9
2.3
e6/l
—
10
85
75
797
0.88
0.29
6.0
3.7
18.0
9.1
mm/h
2.27
67
751
26
225
1.19
0.28
1.2
1.8
0.8
0.9
mg/l
0.29
20
171
14
171
0.80
0.28
1.9
2.0
—
—
—
0
0
60
556
1.14
0.28
6.5
6.2
10.1
10.5
umol/l
0.17
55
531
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
9.0
—
0
5
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
10
123
0.80
0.21
2.1
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
7
87
0.79
0.15
1.9
2.1
—
—
—
0
0
10
118
0.84
0.15
2.0
1.5
—
—
—
0
0
28
258
1.11
0.13
5.6
2.9
318.3
4354.7
umol/l
1.07
28
227
18
163
1.12
0.11
2.5
1.8
—
—
—
0
0
53
508
1.07
0.11
5.2
3.3
0.0
0.0
estimate
0.00
11
101
25
234
1.08
0.09
1.8
1.5
—
—
—
0
0
5
61
0.81
0.08
1.4
1.7
51.4
33.7
nmol/l
—
5
61
5
64
0.77
0.08
1.0
1.0
—
—
—
0
0
7
66
1.06
0.08
1.6
1.3
—
—
—
0
0
42
403
1.06
0.08
5.6
3.4
—
—
—
0
0
6
74
0.80
0.08
2.0
2.1
—
—
—
0
0
17
181
0.93
0.05
1.4
1.3
23.5
7.8
u/ml
—
6
84
48
471
1.03
0.02
5.6
4.3
—
—
—
0
0
15
157
0.95
0.01
1.4
1.4
—
—
—
0
0
33
323
1.03
0.01
8.4
3.4
2.4
2.4
mmol/l
0.00
33
294
105
1057
0.98
0.01
6.6
3.6
1.2
1.3
mmol/l
1.67
97
985
28
274
1.03
0.00
6.1
3.6
0.0
0.0
estimate
—
7
101
109
1096
0.98
0.00
7.7
4.0
4.3
4.7
mmol/l
4.20
103
1027
109
1091
1.00
0.00
7.5
3.9
1.6
1.4
mmol/l
3.90
102
1018
13
125
1.04
0.00
2.2
2.9
4.8
8.1
umol/l
—
8
105
0
6
0.00
0.00
0.0
5.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
121.2
—
0
5
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
3.2
—
97.8
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOCOMA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOCOMA | 4.588 [1.64, 12.87] | 0.004 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 143 males with E4_HYPOCOMA died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPOCOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.841% |
| 5 | No data | 5.63% |
| 10 | No data | 13.552% |
| 15 | No data | 23.531% |
| 20 | No data | 36.266% |
Relationships between endpoints
↥Index endpoint: E4_HYPOCOMA – Nondiabetic hypoglycaemic coma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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