obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
183 |
4. Check minimum number of eventsNone |
183 |
5. Include endpointsNone |
183 |
6. Filter based on genotype QC (FinnGen only) |
183 |
Control definitions (FinnGen only)
- Control exclude
- E4_OBESITY_HYPER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E65-E68
- Name in latin
- Obesitas localisata
Similar endpoints
↥List of similar endpoints to
Localized adiposity
based on the number of shared cases.
Similar with more cases:
- Obesity and other hyperalimentation
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1024 | 788 | 230 |
| Only index persons | 989 | 768 | 221 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.98 | 47.00 | 55.93 |
| Only index persons | 48.80 | 46.87 | 55.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 183 | 150 | 33 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | 49.44 | 48.11 | 55.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 162
- Matched controls
- 1618
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E65
ICD-10 Finland
Localized adiposity
+∞
228.2
160
*
E66.01
ICD-10 Finland
Obesity due to excess calories
64.7
46.8
53
12
QBJ00
NOMESCO Finland
Liposuction in trunk
+∞
41.5
38
*
E66.8
ICD-10 Finland
Other obesity
115.9
41.1
43
5
QBJ30
NOMESCO Finland
Correction of abdominal apron
237.7
37.5
37
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
18.0
17
*
E66.9
ICD-10 Finland
Obesity, unspecified
47.2
14.4
17
*
E66.00
ICD-10 Finland
Metabolic syndrome
18.0
14.4
22
14
QDJ00
NOMESCO Finland
Liposuction in lower extremity
+∞
11.6
11
*
E66
ICD-10 Finland
Obesity
10.7
10.6
20
21
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.1
10.5
29
56
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.0
8.8
16
16
A10BJ06
ATC
semaglutide; parenteral
15.6
8.4
13
9
N02AX02
ATC
tramadol; systemic, rectal
2.7
8.3
85
474
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
9.2
8.0
16
19
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.4
7.9
40
141
N06AB03
ATC
fluoxetine; oral
3.7
7.7
35
113
A10BA02
ATC
metformin; oral
3.0
7.4
47
192
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.1
7.4
29
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
7.4
57
264
C03CA01
ATC
furosemide; systemic
3.1
7.4
45
181
M79.6
ICD-10 Finland
Pain in limb
2.5
7.1
74
408
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.9
7.0
22
50
G47.3
ICD-10 Finland
Sleep apnoea
3.1
6.9
41
160
T82
ICPC
Obesity
8.4
6.8
14
18
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
6.7
76
431
N06AX12
ATC
bupropion; oral
4.6
6.6
22
53
J01DB01
ATC
cefalexin; oral
3.1
6.6
142
1125
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.7
6.6
18
35
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
6.5
42
173
WX002
NOMESCO Finland
Sedation and analgesia
2.8
6.4
45
195
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.1
6.3
24
66
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
6.3
6
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
6.3
6
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
6.2
42
179
N05CF01
ATC
zopiclone; oral
2.4
6.2
61
321
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.3
6.0
30
104
Mortality – FinRegistry
↥Association
Association between endpoint E4_LOCALADIP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_LOCALADIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_LOCALADIP – Localized adiposity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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