obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
188 |
4. Check minimum number of eventsNone |
188 |
5. Include endpointsNone |
188 |
6. Filter based on genotype QC (FinnGen only) |
178 |
Control definitions (FinnGen only)
- Control exclude
- E4_OBESITY_HYPER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E65-E68
- Name in latin
- Obesitas localisata
Similar endpoints
↥List of similar endpoints to
Localized adiposity
based on the number of shared cases.
Similar with more cases:
- Obesity and other hyperalimentation
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1024 | 788 | 230 |
| Only index persons | 989 | 768 | 221 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.98 | 47.00 | 55.93 |
| Only index persons | 48.80 | 46.87 | 55.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 178 | 148 | 30 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 49.90 | 48.71 | 55.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 188
- Matched controls
- 1880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E65
ICD-10 Finland
Localized adiposity
4503599627370496.0
263.6
186
*
E66.01
ICD-10 Finland
Obesity due to excess calories
22.6
81.0
68
46
E66.8
ICD-10 Finland
Other obesity
128.3
53.2
55
6
QBJ30
NOMESCO Finland
Correction of abdominal apron
+∞
49.1
45
*
QBJ00
NOMESCO Finland
Liposuction in trunk
110.6
40.8
43
5
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
21.2
20
*
E66.00
ICD-10 Finland
Metabolic syndrome
23.2
19.8
28
14
E66
ICD-10 Finland
Obesity
7.8
18.8
28
41
E66.9
ICD-10 Finland
Obesity, unspecified
49.5
18.7
22
5
QDJ00
NOMESCO Finland
Liposuction in lower extremity
185.8
16.8
17
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.5
14.9
32
68
A10BA02
ATC
metformin; oral
3.2
11.6
61
246
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.1
11.5
21
38
R60.9
ICD-10 Finland
Oedema, unspecified
5.9
11.2
21
39
C03CA01
ATC
furosemide; systemic
3.0
10.5
60
253
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.2
10.4
51
196
T82
ICPC
Obesity
9.3
10.4
21
25
J45.9
ICD-10 Finland
Asthma, unspecified
3.1
10.2
52
205
N02AX02
ATC
tramadol; systemic, rectal
2.7
10.1
103
584
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.6
10.0
37
119
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.0
9.7
52
210
A10BH01
ATC
sitagliptin; oral
4.5
9.3
24
59
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.4
8.9
35
117
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
8.8
68
332
103
Kela drug reimbursment
Diabetes, insulin-treated
2.9
8.8
52
221
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.0
8.8
21
33
N06AX12
ATC
bupropion; oral
4.0
8.6
26
72
T90
ICPC
Diabetes non-insulin dependent
2.9
8.6
48
197
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
8.4
8
*
N06AB03
ATC
fluoxetine; oral
3.1
8.2
38
140
R03BA05
ATC
fluticasone; inhalant
2.8
8.2
52
229
WX002
NOMESCO Finland
Sedation and analgesia
2.8
7.9
49
212
WX402
NOMESCO Finland
General anaesthesia
2.7
7.9
52
233
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
7.8
67
341
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
7.8
33
115
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.6
7.6
27
84
N06AX21
ATC
duloxetine; oral
3.0
7.4
38
148
J01DB01
ATC
cefalexin; oral
3.8
7.2
171
1363
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
7.1
103
652
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.7
7.1
17
39
J45
ICD-10 Finland
Asthma
3.2
7.1
31
110
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
6.9
46
206
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.6
6.8
24
74
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.7
6.8
23
69
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.3
6.6
26
86
A10BJ06
ATC
semaglutide; parenteral
6.1
6.6
17
30
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
6.6
64
340
SPAT1255
SPAT
Intravenous administration of medicine
4.2
6.6
18
46
G47.3
ICD-10 Finland
Sleep apnoea
2.5
6.6
50
238
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.8
6.5
37
152
QBA00
NOMESCO Finland
Puncture of skin of trunk
72.2
6.5
7
*
N03AX16
ATC
[U] pregabalin
2.3
6.3
58
301
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
6.3
6
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.8
6.1
34
138
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
6.1
29
108
A02BC02
ATC
pantoprazole; systemic
2.3
6.0
140
1045
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.0
82
498
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
229
2.76
8.16
2.3
1.6
1196.19
1251.07
nmol/l
0.18
44
168
101
631
2.30
7.25
13.1
10.4
1.21
1.12
inr
0.45
30
196
109
706
2.29
7.14
9.0
7.0
1.22
1.22
mmol/l
0.01
98
594
41
171
2.79
7.06
2.3
2.2
23.92
23.30
%
0.08
35
151
90
544
2.26
6.90
2.8
1.8
91.19
99.94
pmol/l
1.22
59
258
47
222
2.49
6.27
4.1
3.5
0.81
0.83
mmol/l
0.63
47
210
65
358
2.25
6.11
2.2
1.7
1.03
0.96
mg/l
0.09
47
279
66
371
2.20
5.86
3.8
2.9
753.76
991.56
ng/l
0.44
58
313
98
646
2.08
5.71
3.4
2.2
72.26
77.67
nmol/l
1.30
91
586
156
1235
2.55
5.66
11.1
7.1
81.43
75.02
u/l
1.25
150
1153
34
147
2.60
5.40
17.4
6.9
104.65
104.16
mmol/l
0.30
34
147
28
111
2.79
5.25
3.1
3.3
4.30
4.41
pmol/l
0.29
23
100
22
76
3.15
5.24
9.6
8.6
0.61
0.65
%
0.24
22
76
51
272
2.20
5.07
3.2
3.3
33.13
393.52
ng/l
0.90
31
194
40
193
2.36
5.03
1.9
1.8
—
—
—
0
0
21
73
3.11
4.95
9.8
9.0
93.96
94.18
%
0.09
21
73
115
834
1.98
4.83
7.4
6.1
10.41
10.20
umol/l
0.09
110
793
30
130
2.56
4.73
2.0
1.7
—
—
—
0
0
21
76
2.98
4.62
9.8
8.7
1.16
1.45
%
1.08
21
76
101
714
1.90
4.45
3.1
2.5
—
—
—
0
0
157
1298
2.27
4.31
5.0
4.2
14.52
14.53
pmol/l
0.00
150
1204
63
387
1.94
4.20
6.5
2.6
0.51
0.45
e6/l
0.09
46
286
39
201
2.19
4.17
5.6
2.5
4.28
3.22
e6/l
0.28
18
106
179
1610
3.33
4.13
24.3
11.7
19.82
18.93
mg/l
0.16
155
1208
100
716
1.85
4.13
4.8
2.6
127.58
86.36
ug/l
1.10
95
673
41
218
2.13
4.05
5.4
2.3
0.62
0.91
e6/l
0.63
21
122
26
116
2.44
3.85
8.5
11.7
121.00
120.62
g/l
0.03
26
111
28
130
2.36
3.81
2.0
1.6
—
—
—
0
0
28
131
2.34
3.74
9.2
10.7
5.40
5.19
kpa
0.36
28
124
28
131
2.34
3.74
9.2
10.7
11.34
12.16
kpa
0.48
28
125
170
1480
2.55
3.69
7.6
4.7
40.81
38.70
mmol/mol
1.77
164
1394
59
371
1.86
3.60
1.4
1.2
0.61
2.57
u/ml
0.89
16
99
60
380
1.85
3.57
3.9
3.3
7.89
7.00
mg/mmol
0.08
42
215
11
26
4.43
3.57
6.2
2.4
7.56
7.93
kpa
0.21
11
26
172
1513
2.61
3.51
6.4
4.9
1.76
1.83
mu/l
0.38
167
1408
175
1559
2.77
3.34
5.2
4.1
5.99
5.73
mmol/l
1.72
170
1451
15
54
2.93
3.34
21.7
3.5
23.76
24.68
mmol/l
0.62
15
54
73
503
1.74
3.23
6.8
2.8
—
—
—
0
0
28
140
2.17
3.21
1.2
1.2
93.10
193.20
iu/ml
—
7
60
53
335
1.81
3.13
1.4
1.3
37.23
31.20
iu/ml
0.10
23
122
76
535
1.71
3.09
5.2
3.4
2.35
2.36
mmol/l
0.21
71
477
20
88
2.42
3.06
2.4
1.7
—
—
—
0
0
188
1804
+∞
3.04
34.1
17.7
39.91
40.19
%
0.25
181
1721
11
32
3.59
2.95
10.3
2.9
24.45
25.20
mmol/l
0.14
11
32
10
28
3.71
2.83
1.8
1.4
—
—
—
0
0
10
28
3.71
2.83
1.8
1.4
—
—
—
0
0
15
60
2.63
2.78
1.7
1.5
—
—
—
0
0
115
925
1.63
2.64
14.4
9.6
4.26
3.89
e9/l
0.80
105
816
51
335
1.72
2.60
1.5
1.3
5.91
7.20
u/ml
0.09
22
131
19
89
2.26
2.55
1.2
1.0
—
—
—
0
0
171
1544
2.19
2.52
4.6
3.8
1.44
1.23
mmol/l
2.89
164
1436
169
1522
2.09
2.47
21.4
11.1
88.67
84.18
ml/min/173m2
2.16
148
1248
143
1229
1.68
2.40
5.8
3.8
14.42
10.09
mm/h
2.18
138
1141
5
8
6.38
2.38
1.0
1.0
—
—
—
0
0
51
347
1.64
2.26
2.5
2.3
—
—
—
0
0
27
154
1.88
2.18
3.3
2.3
28.64
31.27
u/l
0.39
22
128
160
1430
1.80
2.18
28.5
14.5
15.36
14.60
%
0.85
160
1411
7
19
3.78
2.17
1.3
1.2
—
—
—
0
0
15
69
2.28
2.11
3.6
5.2
24.85
25.72
mmol/l
0.28
15
69
61
441
1.57
2.10
1.6
1.7
1.45
1.36
mmol/l
0.44
55
379
5
10
5.10
2.08
1.6
1.3
—
—
—
0
0
98
787
1.51
2.08
4.4
3.4
0.00
0.02
estimate
0.50
14
161
174
1603
2.15
2.07
5.0
4.2
1.38
1.56
mmol/l
7.93
168
1499
23
127
1.92
2.05
1.6
1.3
22.09
30.47
iu/l
0.77
23
108
15
72
2.18
1.92
1.4
1.4
—
—
—
0
0
96
778
1.48
1.89
4.3
3.3
0.00
0.00
estimate
-0.00
15
172
18
94
2.01
1.87
1.5
1.5
—
—
—
0
0
14
66
2.21
1.87
22.5
2.3
0.66
0.66
%
0.01
14
66
6
17
3.61
1.85
2.7
1.9
—
—
—
0
0
6
18
3.41
1.76
1.0
1.1
—
—
—
0
0
24
142
1.79
1.75
5.1
3.0
—
—
—
0
0
7
24
2.99
1.74
2.6
1.5
—
—
—
0
0
11
49
2.32
1.67
1.1
1.1
—
3.01
—
0
9
175
1640
1.97
1.58
5.7
4.6
2.83
2.91
mmol/l
0.51
169
1532
94
780
1.41
1.53
6.4
4.5
0.00
0.00
estimate
-0.00
16
163
6
21
2.92
1.52
1.7
1.2
—
—
—
0
0
6
21
2.92
1.52
1.7
1.2
—
—
—
0
0
7
28
2.56
1.46
1.4
1.5
—
—
—
0
0
9
39
2.37
1.45
1.9
2.4
—
—
—
0
0
6
22
2.78
1.44
1.8
1.2
—
—
—
0
0
6
22
2.78
1.44
1.8
1.2
—
—
—
0
0
6
22
2.78
1.44
1.8
1.2
—
—
—
0
0
45
329
1.48
1.43
4.3
3.6
1.01
1.02
kg/l
0.52
13
35
13
69
1.95
1.32
24.0
2.2
0.99
1.18
%
0.45
13
69
29
196
1.57
1.32
1.9
1.8
—
—
—
0
0
5
18
2.82
1.29
1.2
1.2
—
—
—
0
0
7
30
2.38
1.13
2.0
2.5
—
—
—
0
0
7
32
2.23
1.09
1.1
1.2
—
—
—
0
0
7
33
2.16
1.06
2.6
1.5
—
—
—
0
0
13
75
1.79
1.05
1.4
1.4
—
—
—
0
0
9
51
1.80
0.96
1.9
2.2
—
—
—
0
0
9
52
1.77
0.94
1.6
1.3
—
10.29
—
0
11
6
29
2.10
0.90
1.0
1.0
—
—
—
0
0
8
44
1.85
0.87
1.6
1.3
—
—
—
0
0
6
32
1.90
0.82
1.7
1.5
10.18
35.96
u/l
—
6
26
51
418
1.30
0.82
4.0
3.7
0.00
0.00
estimate
-0.00
16
163
19
133
1.48
0.77
1.7
2.5
71.50
67.09
ml/min/173m2
—
6
54
6
34
1.79
0.77
1.7
1.6
—
—
—
0
0
5
24
2.11
0.75
2.6
1.8
—
—
—
0
0
71
614
1.25
0.74
3.6
3.4
—
—
—
0
0
7
39
1.82
0.73
1.0
1.1
4.13
3.86
mmol/l
—
7
34
5
26
1.95
0.71
1.2
1.9
—
—
—
0
0
5
27
1.87
0.69
1.2
1.1
—
—
—
0
0
5
28
1.81
0.66
1.4
1.5
—
—
—
0
0
12
81
1.51
0.58
16.8
12.0
24.32
25.18
mmol/l
0.18
12
76
23
177
1.34
0.58
1.8
1.7
—
—
—
0
0
120
1116
1.21
0.58
3.7
3.3
—
—
—
0
0
5
89
0.55
0.57
1.6
1.4
—
—
—
0
0
6
36
1.69
0.57
1.7
1.3
—
—
—
0
0
9
59
1.55
0.56
3.6
3.1
49.87
51.03
%
—
9
59
6
39
1.56
0.53
11.0
3.4
3.83
3.88
mmol/l
—
6
39
6
40
1.52
0.52
4.7
1.7
—
—
—
0
0
42
357
1.23
0.51
1.6
1.4
—
—
—
0
0
7
45
1.58
0.49
1.1
1.1
—
—
—
0
0
7
45
1.58
0.49
1.4
1.2
—
—
—
0
0
24
194
1.27
0.44
2.0
1.8
—
—
—
0
0
7
51
1.39
0.44
1.0
1.2
—
—
—
0
0
5
33
1.53
0.41
1.2
1.8
—
—
—
0
0
5
33
1.53
0.41
1.2
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
60
545
1.15
0.35
4.6
3.4
21.43
25.61
ng/l
0.32
37
342
6
45
1.34
0.34
1.5
1.7
—
—
—
0
0
10
75
1.35
0.31
1.1
1.3
—
—
—
0
0
9
116
0.76
0.28
4.4
3.5
1.24
1.23
mmol/l
—
9
104
8
63
1.28
0.28
1.0
1.6
—
—
—
0
0
8
63
1.28
0.28
8.5
1.7
—
—
—
0
0
16
190
0.83
0.24
7.7
6.1
—
—
—
0
0
31
347
0.87
0.24
1.7
1.5
—
—
—
0
0
15
125
1.22
0.23
1.3
1.3
—
30.08
—
0
6
5
40
1.26
0.22
1.8
1.6
—
—
—
0
0
5
42
1.20
0.21
2.2
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
15
176
0.84
0.21
3.9
4.1
29.80
32.75
%
0.67
15
111
6
49
1.23
0.20
2.3
1.8
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
7
60
1.17
0.18
1.1
1.8
—
—
—
0
0
11
93
1.19
0.15
1.3
1.4
—
—
—
0
0
18
164
1.11
0.10
4.9
4.3
6.80
6.86
ug/l
0.00
12
130
20
188
1.07
0.06
2.5
4.3
20.19
21.95
%
—
6
76
14
145
0.96
0.00
1.9
2.5
0.66
0.72
ug/l
—
8
79
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
7.45
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.20
—
0
6
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
2555.17
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
0.29
—
0
7
7
70
1.00
-0.00
1.9
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_LOCALADIP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_LOCALADIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_LOCALADIP – Localized adiposity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data