Localized adiposity

E4_LOCALADIP

obesity: A disorder involving an excessive amount of body fat.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E65 Hospital discharge: ICD-9 — 2781 Cause of death: ICD-10 — E65 Cause of death: ICD-9 — 2781 2 out of 7 registries used, show all original rules.	183
4. Check minimum number of events None	183
5. Include endpoints None	183
6. Filter based on genotype QC (FinnGen only)	183

Control definitions (FinnGen only)

Control exclude: E4_OBESITY_HYPER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E65-E68
Name in latin: Obesitas localisata

NAME	E4_LOCALADIP
CONTROL_EXCLUDE	E4_OBESITY_HYPER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E65
HD_ICD_9	2781
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E65
COD_ICD_9	2781
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Localized adiposity based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1024	788	230
Only index persons	989	768	221
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.03	0.01
Median age at first event (years)
Whole population	48.98	47.00	55.93
Only index persons	48.80	46.87	55.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	183	150	33
Unadjusted period prevalence (%)	0.04	0.05	0.01
Median age at first event (years)	49.44	48.11	55.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
162: Matched controls
1618

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E65

ICD-10 Finland

Localized adiposity

+∞

228.2

160

E66.01

ICD-10 Finland

Obesity due to excess calories

64.7

46.8

QBJ00

NOMESCO Finland

Liposuction in trunk

+∞

41.5

E66.8

ICD-10 Finland

Other obesity

115.9

41.1

QBJ30

NOMESCO Finland

Correction of abdominal apron

237.7

37.5

JDF11

NOMESCO Finland

Laparoscopic gastric bypass

+∞

18.0

E66.9

ICD-10 Finland

Obesity, unspecified

47.2

14.4

E66.00

ICD-10 Finland

Metabolic syndrome

18.0

14.4

QDJ00

NOMESCO Finland

Liposuction in lower extremity

+∞

11.6

E66

ICD-10 Finland

Obesity

10.7

10.6

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

6.1

10.5

346

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

11.0

8.8

A10BJ06

ATC

semaglutide; parenteral

15.6

8.4

N02AX02

ATC

tramadol; systemic, rectal

2.7

8.3

474

285

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

9.2

8.0

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

3.4

7.9

141

N06AB03

ATC

fluoxetine; oral

3.7

7.7

113

A10BA02

ATC

metformin; oral

3.0

7.4

192

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

4.1

7.4

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.8

7.4

264

C03CA01

ATC

furosemide; systemic

3.1

7.4

181

M79.6

ICD-10 Finland

Pain in limb

2.5

7.1

408

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

4.9

7.0

G47.3

ICD-10 Finland

Sleep apnoea

3.1

6.9

160

T82

ICPC

Obesity

8.4

6.8

N02AJ06

ATC

codeine and paracetamol; systemic

2.4

6.7

431

N06AX12

ATC

bupropion; oral

4.6

6.6

J01DB01

ATC

cefalexin; oral

3.1

6.6

142

1125

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

5.7

6.6

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.9

6.5

173

WX002

NOMESCO Finland

Sedation and analgesia

2.8

6.4

195

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

4.1

6.3

QBJ05

NOMESCO Finland

Other correction of loose or redundant skin of trunk

+∞

6.3

E66.2

ICD-10 Finland

Extreme obesity with alveolar hypoventilation

+∞

6.3

103

Kela drug reimbursment

Diabetes, insulin-treated

2.8

6.2

179

N05CF01

ATC

zopiclone; oral

2.4

6.2

321

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

3.3

6.0

104

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

304

2.70

8.78

7.2

4.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

226

2.82

8.42

2.4

1.6

nmol/l

1196.2

1256.7

0.20

167

(3044640) Blood type and Crossmatch panel - Blood

453

2.47

8.10

2.4

2.3

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

169

2.84

7.25

2.3

23.9

23.2

0.10

150

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

531

2.27

6.81

2.8

1.8

pmol/l

90.6

99.2

1.20

253

(3012095) Magnesium [Moles/volume] in Serum or Plasma

219

2.54

6.49

4.1

3.5

mmol/l

0.8

0.34

206

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

105

692

2.21

6.42

9.2

7.0

mmol/l

1.2

0.06

582

(40768797) Stomach Pathology biopsy report

207

2.56

6.37

1.2

—

(42870588) Differential panel, method unspecified - Blood

488

2.14

5.80

8.4

5.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

630

2.10

5.72

3.4

2.2

nmol/l

72.5

77.0

0.98

572

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

353

2.20

5.64

2.2

1.7

mg/l

1.1

1.0

0.13

277

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

5.51

5.60

1.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

261

2.26

5.28

3.2

3.3

ng/l

34.0

406.0

0.90

188

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

151

1204

2.45

5.20

11.3

7.1

u/l

81.6

75.1

1.22

145

1125

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.11

5.13

9.6

8.4

0.6

0.7

0.32

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

192

2.39

5.11

1.9

1.8

—

(3026008) Bacteria identified in Urine by Culture

407

2.07

5.05

5.6

2.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

369

2.08

4.94

3.9

2.9

ng/l

789.0

992.6

0.35

312

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

129

2.59

4.82

2.0

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.03

4.73

9.8

8.6

94.0

93.5

0.16

(3032080) INR in Blood by Coagulation assay

526

1.97

4.72

9.7

6.3

inr

1.1

0.19

166

(3022217) INR in Platelet poor plasma by Coagulation assay

157

2.43

4.71

15.4

20.2

inr

1.6

1.2

—

(3000991) Gas panel - Venous blood

100

2.74

4.61

20.2

7.7

—

(3019198) Lymphocytes [#/volume] in Blood

110

799

1.94

4.55

10.2

5.3

e9/l

2.0

1.9

0.55

716

(3016502) Oxygen saturation in Arterial blood

120

2.57

4.52

9.0

11.4

95.4

95.5

0.03

115

(3044889) 12 lead EKG panel

137

1075

2.09

4.51

3.6

3.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

111

811

1.94

4.48

7.5

6.2

umol/l

10.5

10.2

0.12

106

775

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.91

4.43

9.8

8.3

1.2

1.6

1.24

(36304419) Bacteria [Presence] in Urine

374

1.99

4.41

6.5

2.6

—

(3001604) Monocytes [#/volume] in Blood

107

776

1.91

4.38

10.0

5.3

e9/l

0.6

0.5

0.96

679

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

701

1.90

4.35

5.3

4.1

—

(3006315) Basophils [#/volume] in Blood

107

778

1.90

4.32

10.0

5.4

e9/l

0.0

0.08

681

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.11

4.31

6.8

16.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

164

2.32

4.26

2.4

1.5

—

(3012516) Albumin [Mass/volume] in Urine

356

1.97

4.16

3.2

2.9

mg/l

56.3

44.5

0.13

211

(3001122) Ferritin [Mass/volume] in Serum or Plasma

699

1.87

4.14

4.8

2.6

ug/l

128.1

87.3

1.05

657

(3013115) Eosinophils [#/volume] in Blood

109

805

1.88

4.12

10.3

6.0

e9/l

0.2

0.14

722

(3018095) Leukocytes [#/volume] in Urine

504

1.87

4.01

8.2

3.3

e6/l

81.2

64.4

0.21

342

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

197

2.17

4.01

5.7

2.6

e6/l

4.5

3.3

0.29

103

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

152

1262

2.21

4.00

4.9

4.2

pmol/l

14.6

14.5

0.11

145

1172

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

128

2.40

3.95

2.0

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

372

1.91

3.87

6.7

2.7

e6/l

0.5

0.11

275

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

174

1570

3.20

3.83

24.6

11.9

mg/l

20.0

19.0

0.16

151

1183

(3027801) Oxygen [Partial pressure] in Arterial blood

130

2.36

3.82

9.2

10.7

kpa

11.3

12.1

0.45

125

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

130

2.36

3.82

9.2

10.7

kpa

5.4

5.2

0.30

124

(3020682) Albumin/Creatinine [Ratio] in Urine

377

1.88

3.70

3.9

3.5

mg/mmol

7.9

0.00

215

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.84

3.70

1.7

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

394

1.87

3.69

3.2

2.8

mmol/l

8.2

7.5

0.53

333

(3002582) Erythrocytes [#/volume] in Urine

411

1.86

3.68

7.2

2.9

e6/l

25.6

60.1

0.92

313

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

211

2.08

3.68

5.6

2.4

e6/l

0.7

0.9

0.57

116

(3012544) pH of Venous blood

113

2.40

3.61

14.8

3.7

—

(3023520) Reticulocytes [#/volume] in Blood

2.52

3.57

3.0

3.9

e9/l

67.5

72.1

0.20

(3006653) Thiamine [Moles/volume] in Blood

10.28

3.52

2.3

1.5

nmol/l

122.3

152.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

130

1047

1.83

3.40

5.5

4.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

104

2.39

3.32

1.1

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

165

1448

2.42

3.29

7.6

4.8

mmol/mol

41.0

38.8

1.85

159

1364

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

167

1474

2.52

3.27

6.3

4.9

mu/l

1.7

1.8

0.65

162

1373

(3009343) pH of Capillary blood

2.69

3.23

5.0

4.3

—

7.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.49

3.21

2.5

1.7

—

(40758558) Short blood count panel - Blood

402

1.78

3.16

10.1

7.4

—

(3002256) Pathology report gross observation

200

2.00

3.15

1.3

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

170

1526

2.61

2.95

5.2

4.1

mmol/l

6.0

5.7

1.68

165

1421

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.47

2.95

1.8

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.47

2.95

1.8

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

488

1.70

2.94

7.1

2.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

360

1.75

2.88

1.3

1.2

u/ml

0.6

2.7

0.91

(3035941) MCH [Entitic mass]

183

1757

+∞

2.85

32.7

18.0

30.3

0.07

183

1740

(3024731) MCV [Entitic volume]

183

1757

+∞

2.85

32.8

18.0

91.4

91.0

0.58

183

1740

(3042936) Bacteria identified in Isolate by Culture

186

1.94

2.76

2.4

2.0

—

(3018418) pH of Serum or Plasma

434

1.69

2.73

4.9

3.7

7.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

523

1.66

2.73

5.4

3.4

mmol/l

2.4

0.20

464

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.59

2.70

1.7

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

326

1.73

2.64

1.4

1.3

iu/ml

38.7

31.2

0.12

115

(4062490)

4.50

2.50

1.4

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

112

907

1.61

2.46

14.6

9.8

e9/l

4.2

3.9

0.67

102

801

(3048689) Calprotectin [Mass/mass] in Stool

203

1.83

2.39

1.3

1.9

ug/g

148.5

126.6

0.14

164

(40768443) Skin Pathology biopsy report

2.42

2.38

1.2

1.3

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

6.39

2.38

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

6.39

2.38

8.8

3.5

mu/l

14.1

7.4

—

(3000492) Spirometry study

150

1.94

2.36

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

136

1.97

2.32

1.2

iu/ml

100.3

190.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.21

2.32

1.2

1.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

139

1198

1.67

2.27

5.8

3.9

mm/h

14.5

10.2

2.08

134

1116

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

166

1508

2.09

2.24

4.7

3.8

mmol/l

1.4

1.2

2.75

159

1403

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

340

1.65

2.23

2.6

2.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

5.67

2.22

1.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

164

1485

2.01

2.21

21.6

11.2

ml/min/173m2

88.5

83.9

2.14

143

1221

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.31

2.17

3.6

4.5

mmol/l

24.8

25.7

0.27

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.31

2.17

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.79

2.17

1.3

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

327

1.63

2.12

1.4

1.3

u/ml

6.1

7.4

0.08

126

(3000850) Epithelial cells [#/volume] in Urine

294

1.65

2.09

6.0

2.4

e6/l

7.2

8.3

0.15

262

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

5.10

2.08

1.6

1.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

149

1.87

2.08

3.3

2.4

u/l

28.3

31.0

0.38

124

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.54

1.97

1.1

—

3.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

326

1.59

1.92

2.3

1.3

g/l

2.2

0.19

194

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

154

1.80

1.88

1.5

1.8

—

(3024928) Oxygen saturation in Venous blood

2.94

1.88

36.4

2.9

—

(4268621)

3.61

1.85

2.7

1.9

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.25

1.83

1.0

3.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

169

1566

2.04

1.81

5.0

4.2

mmol/l

1.4

1.6

7.52

163

1464

(3013512) EKG study

403

1.52

1.76

2.8

3.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

3.41

1.76

1.0

1.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.41

1.76

1.7

1.2

—

(3022313) Gas panel - Capillary blood

2.37

1.74

4.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

160

1462

1.75

1.74

26.5

12.6

39.6

40.1

0.33

123

1158

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.99

1.74

2.6

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

2.99

1.74

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

143

1.78

1.71

5.1

3.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

120

1.85

1.71

1.6

1.3

iu/l

23.8

30.7

0.55

103

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

434

1.49

1.67

1.6

1.7

mmol/l

1.4

0.36

373

(3023410) Appearance of Cerebral spinal fluid

3.23

1.67

1.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.87

1.66

1.0

1.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

3.64

1.62

1.6

1.3

umol/l

11.8

28.2

—

(3021440) Promyelocytes/100 leukocytes in Blood

115

1.83

1.60

2.4

4.8

0.0

0.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.35

1.56

1.4

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

3.40

1.53

1.0

1.1

—

(3044941) Cell count panel - Synovial fluid

2.92

1.52

1.7

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

763

1.41

1.51

4.4

3.4

estimate

0.0

0.00

162

(3009261) Glucose [Presence] in Urine by Test strip

775

1.41

1.48

4.5

3.4

estimate

0.0

0.50

159

(3023511) Choriogonadotropin [Units/volume] in Urine

2.44

1.48

1.2

1.3

—

(3017181) Myelocytes/100 leukocytes in Blood

126

1.75

1.48

2.4

4.6

0.6

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.90

1.47

1.4

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.56

1.46

1.4

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

149

1354

1.54

1.46

29.6

14.8

14.2

13.6

2.10

149

1334

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.37

1.45

1.9

2.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.18

1.44

4.6

1.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.18

1.44

5.2

7.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

170

1600

1.88

1.39

5.7

4.6

mmol/l

2.8

2.9

0.56

164

1493

(3019230) Fractional oxyhemoglobin in Venous blood

2.66

1.38

48.2

1.9

54.8

56.1

—

(3021901) Oxygen saturation in Capillary blood

2.66

1.38

10.0

2.6

—

(3023419) Bacteria identified in Sputum by Culture

2.99

1.37

5.4

2.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

162

1.63

1.35

1.8

1.5

—

(3019150) Specific gravity of Urine by Refractometry

325

1.47

1.34

4.3

3.6

kg/l

1.0

0.49

(3021589) Normoblasts [#/volume] in Blood

690

1.37

1.29

14.5

8.6

e9/l

0.0

0.23

561

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.92

1.27

24.0

2.2

1.0

1.2

0.61

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.28

1.26

6.3

2.0

234.4

186.6

—

(3044290) Cell count panel - Cerebral spinal fluid

2.28

1.26

1.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.45

1.25

1.0

1.4

—

(3047181) Lactate [Moles/volume] in Blood

2.21

1.23

2.1

19.1

mmol/l

1.7

1.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

2.68

1.22

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

336

1.41

1.12

4.9

3.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.31

1.11

2.0

2.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.31

1.11

1.1

1.2

—

(21494755) Public health laboratory ask at order entry panel

203

0.56

1.11

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

2.42

1.10

1.4

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.42

1.10

1.4

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

2.42

1.10

1.4

1.2

—

(3045414) Leukocytes [Presence] in Urine

1.85

1.07

1.3

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

2.31

1.04

1.4

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

2.31

1.04

1.4

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

2.31

1.04

1.4

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

768

1.31

1.01

6.7

4.6

estimate

0.0

0.00

161

(46235355) HIV 1 and 2 tests - Meaningful Use set

263

1.41

0.98

2.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.80

0.96

1.9

2.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.26

0.94

1.0

—

(3037756) Immunofixation for Serum or Plasma

2.26

0.94

1.3

1.6

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.77

0.94

1.4

1.3

—

3.4

—

(3003694) ABO and Rh group [Type] in Blood

421

1.33

0.92

1.6

1.4

—

(3019225) pH of Specimen

120

1.55

0.89

2.6

4.9

—

(40768804) Tissue Pathology biopsy report

680

1.28

0.89

2.3

1.9

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.90

0.88

1.6

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.03

0.87

1.8

1.5

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

1.97

0.85

1.7

1.5

u/l

10.2

37.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

191

1.42

0.83

2.0

1.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.79

0.77

1.7

1.6

—

(3019060) Gas panel - Arterial blood

1.64

0.77

8.8

10.9

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.73

0.76

1.6

1.3

—

10.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

221

1.37

0.76

1.8

1.5

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

1.83

0.73

1.0

1.1

mmol/l

4.1

3.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.03

0.73

1.2

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.03

0.73

2.6

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.03

0.73

1.2

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.78

0.72

1.0

1.4

—

(40761511) CBC panel - Blood by Automated count

171

1651

1.54

0.70

17.2

11.2

—

(3000494) Fungus identified in Specimen by Culture

180

1.38

0.69

2.1

1.5

—

(3022621) pH of Urine by Test strip

1.55

0.68

3.8

2.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.81

0.66

1.4

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

413

1.25

0.64

4.1

3.7

estimate

0.0

0.00

161

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.58

0.63

1.3

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

117

1083

1.22

0.62

3.7

3.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.54

0.61

16.8

12.2

mmol/l

24.3

25.1

0.17

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.60

0.0

1.1

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

132

1.40

0.60

1.8

2.5

ml/min/173m2

68.8

67.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.56

0.58

1.6

1.4

—

(3037121) Protein [Mass/volume] in Urine

1.60

0.55

3.7

3.9

g/l

0.1

0.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.47

0.54

3.6

3.1

49.9

51.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

605

1.20

0.52

3.7

3.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.58

0.49

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.54

0.49

1.4

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.54

0.49

1.4

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.39

0.44

1.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.39

0.44

1.1

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

1.63

0.43

1.6

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

186

1.27

0.43

2.0

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.58

0.42

1.2

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.58

0.42

1.2

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.53

0.41

1.8

1.2

—

(3045424) Erythrocytes [Presence] in Urine

1.53

0.41

1.2

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.41

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.39

0.41

2.6

2.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.35

0.41

1.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

349

1.19

0.38

1.7

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

171

1.26

0.38

1.8

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

124

0.71

0.36

1.1

1.8

—

(3049717) Cytology report of Urine Cyto stain

1.41

0.35

1.7

2.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

188

0.78

0.35

7.6

6.1

—

(3008898) HLA-B27 [Presence]

1.34

0.34

1.3

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.34

0.34

1.5

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

1.29

0.32

11.2

3.1

mmol/l

1.2

1.4

—

(3016879) Cocaine [Presence] in Urine

1.33

0.31

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.26

0.30

1.4

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.24

0.29

1.4

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.24

0.29

1.4

1.3

—

(3027008) Opiates [Presence] in Urine

1.24

0.29

1.4

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.26

0.28

8.5

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

339

0.86

0.27

1.7

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.20

0.26

1.1

—

(40768793) Breast Pathology biopsy report

1.20

0.26

1.0

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

536

1.12

0.26

4.6

3.5

ng/l

22.2

25.8

0.25

336

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.24

0.26

1.1

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

391

1.13

0.25

5.7

4.7

—

(1761868) Lipid panel - Serum or Plasma

646

1.11

0.24

3.1

2.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

134

1.21

0.23

2.6

2.4

—

8.3

—

(3052851) Hemolysis interference index of Serum or Plasma

1.36

0.23

9.0

2.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.32

0.23

5.4

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.29

0.23

1.8

1.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.23

0.22

2.2

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

453

1.11

0.22

3.6

3.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

3.9

—

(36660697) Celiac disease serology panel - Serum

136

1.19

0.21

1.5

1.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.21

0.0

1.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

174

1.17

0.20

1.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

115

0.77

0.20

4.4

3.5

mmol/l

1.2

—

104

(40768806) Pleura Pathology biopsy report

0.00

0.20

0.0

1.7

—

(4027681)

0.00

0.20

0.0

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.23

0.20

2.3

1.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.24

0.19

1.3

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.18

0.19

1.0

1.2

—

(3020891) Body temperature

1.16

0.19

13.2

3.9

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

174

0.85

0.18

3.9

4.1

29.8

32.7

0.66

108

(4010399)

102

1.19

0.15

1.3

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

122

1.16

0.14

1.4

1.3

—

30.1

—

(4035726)

148

0.87

0.13

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.19

0.12

1.2

—

(3000330) Specific gravity of Urine by Test strip

1.05

0.08

1.5

3.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.05

0.08

1.9

1.4

—

(1002224) Polysomnography panel

1.06

0.07

1.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

157

1.09

0.07

5.1

4.4

ug/l

7.3

7.1

0.01

123

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

128

1.10

0.07

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

187

1.08

0.06

2.4

4.3

20.2

22.0

—

(3022145) Colonoscopy Study observation

188

1.07

0.06

1.5

1.3

—

(40761536) Microorganisms panel - Urine sediment

138

0.94

0.02

2.9

3.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

103

1.07

0.02

2.0

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

144

0.97

0.00

1.9

2.5

ug/l

0.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

139

1.01

0.00

1.6

1.7

—

(40761535) Cells panel - Urine sediment

115

1.05

0.00

3.6

3.3

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.1

—

7.6

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.87

0.00

1.0

1.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

5.9

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

17.2

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.3

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.00

0.00

1.2

1.9

—

(44786774) Adalimumab [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

10.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3013293) Extractable nuclear Ab [Presence] in Serum

0.00

0.0

1.8

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.9

—

(3017704) Immunofixation for Urine

0.00

0.0

1.7

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

2416.5

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3030862) Granulocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.9

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.9

—

(36304052) Adalimumab Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.3

—

(3025443) Phadiatop IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4146454)

0.00

0.0

1.8

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.93

0.00

2.7

2.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

20.4

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_LOCALADIP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_LOCALADIP.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_LOCALADIP – Localized adiposity

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Localized adiposity

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints