Localized adiposity

E4_LOCALADIP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E65
  • Hospital discharge: ICD-9 2781
  • Cause of death: ICD-10 E65
  • Cause of death: ICD-9 2781

2 out of 7 registries used, show all original rules.

183

4. Check minimum number of events

None

183

5. Include endpoints

None

183

6. Filter based on genotype QC (FinnGen only)

183

Control definitions (FinnGen only)

Control exclude
E4_OBESITY_HYPER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E65-E68
Name in latin
Obesitas localisata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1024 788 230
Only index persons 989 768 221
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.03 0.01
Median age at first event (years)
Whole population 48.98 47.00 55.93
Only index persons 48.80 46.87 55.48

-FinnGen-

Key figures

All Female Male
Number of individuals 183 150 33
Unadjusted period prevalence (%) 0.04 0.05 0.01
Median age at first event (years) 49.44 48.11 55.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
162
Matched controls
1618
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E65
ICD-10 Finland
Localized adiposity
+∞
228.2
160
*
E66.01
ICD-10 Finland
Obesity due to excess calories
64.7
46.8
53
12
QBJ00
NOMESCO Finland
Liposuction in trunk
+∞
41.5
38
*
E66.8
ICD-10 Finland
Other obesity
115.9
41.1
43
5
QBJ30
NOMESCO Finland
Correction of abdominal apron
237.7
37.5
37
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
18.0
17
*
E66.9
ICD-10 Finland
Obesity, unspecified
47.2
14.4
17
*
E66.00
ICD-10 Finland
Metabolic syndrome
18.0
14.4
22
14
QDJ00
NOMESCO Finland
Liposuction in lower extremity
+∞
11.6
11
*
E66
ICD-10 Finland
Obesity
10.7
10.6
20
21
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.1
10.5
29
56
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.0
8.8
16
16
A10BJ06
ATC
semaglutide; parenteral
15.6
8.4
13
9
N02AX02
ATC
tramadol; systemic, rectal
2.7
8.3
85
474
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
9.2
8.0
16
19
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.4
7.9
40
141
N06AB03
ATC
fluoxetine; oral
3.7
7.7
35
113
A10BA02
ATC
metformin; oral
3.0
7.4
47
192
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.1
7.4
29
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
7.4
57
264
C03CA01
ATC
furosemide; systemic
3.1
7.4
45
181
M79.6
ICD-10 Finland
Pain in limb
2.5
7.1
74
408
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.9
7.0
22
50
G47.3
ICD-10 Finland
Sleep apnoea
3.1
6.9
41
160
T82
ICPC
Obesity
8.4
6.8
14
18
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
6.7
76
431
N06AX12
ATC
bupropion; oral
4.6
6.6
22
53
J01DB01
ATC
cefalexin; oral
3.1
6.6
142
1125
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.7
6.6
18
35
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
6.5
42
173
WX002
NOMESCO Finland
Sedation and analgesia
2.8
6.4
45
195
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.1
6.3
24
66
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
6.3
6
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
6.3
6
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
6.2
42
179
N05CF01
ATC
zopiclone; oral
2.4
6.2
61
321
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.3
6.0
30
104

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
304
2.70
8.78
7.2
4.2
—
—
—
0
0
52
226
2.82
8.42
2.4
1.6
1196.2
1256.7
nmol/l
0.20
44
167
82
453
2.47
8.10
2.4
2.3
—
—
—
0
0
41
169
2.84
7.25
2.3
2.3
23.9
23.2
%
0.10
35
150
88
531
2.27
6.81
2.8
1.8
90.6
99.2
pmol/l
1.20
58
253
47
219
2.54
6.49
4.1
3.5
0.8
0.8
mmol/l
0.34
47
206
45
207
2.56
6.37
1.2
1.2
—
—
—
0
0
80
488
2.14
5.80
8.4
5.2
—
—
—
0
0
63
353
2.20
5.64
2.2
1.7
1.1
1.0
mg/l
0.13
45
277
11
21
5.51
5.60
1.0
1.0
—
—
—
0
0
50
261
2.26
5.28
3.2
3.3
34.0
406.0
ng/l
0.90
30
188
151
1204
2.45
5.20
11.3
7.1
81.6
75.1
u/l
1.22
145
1125
22
77
3.11
5.13
9.6
8.4
0.6
0.7
%
0.32
22
77
68
407
2.07
5.05
5.6
2.6
—
—
—
0
0
21
75
3.03
4.73
9.8
8.6
94.0
93.5
%
0.16
21
75
81
526
1.97
4.72
9.7
6.3
1.1
1.1
inr
0.19
22
166
34
157
2.43
4.71
15.4
20.2
1.6
1.2
inr
—
8
26
25
100
2.74
4.61
20.2
7.7
—
—
—
0
0
110
799
1.94
4.55
10.2
5.3
2.0
1.9
e9/l
0.55
98
716
28
120
2.57
4.52
9.0
11.4
95.4
95.5
%
0.03
28
115
137
1075
2.09
4.51
3.6
3.4
—
—
—
0
0
111
811
1.94
4.48
7.5
6.2
10.5
10.2
umol/l
0.12
106
775
21
78
2.91
4.43
9.8
8.3
1.2
1.6
%
1.24
21
78
62
374
1.99
4.41
6.5
2.6
—
—
—
0
0
107
776
1.91
4.38
10.0
5.3
0.6
0.5
e9/l
0.96
96
679
107
778
1.90
4.32
10.0
5.4
0.0
0.0
e9/l
0.08
95
681
18
62
3.11
4.31
6.8
16.7
—
—
—
0
0
34
164
2.32
4.26
2.4
1.5
—
—
—
0
0
59
356
1.97
4.16
3.2
2.9
56.3
44.5
mg/l
0.13
42
211
98
699
1.87
4.14
4.8
2.6
128.1
87.3
ug/l
1.05
93
657
109
805
1.88
4.12
10.3
6.0
0.2
0.2
e9/l
0.14
98
722
76
504
1.87
4.01
8.2
3.3
81.2
64.4
e6/l
0.21
54
342
152
1262
2.21
4.00
4.9
4.2
14.6
14.5
pmol/l
0.11
145
1172
60
372
1.91
3.87
6.7
2.7
0.5
0.5
e6/l
0.11
43
275
174
1570
3.20
3.83
24.6
11.9
20.0
19.0
mg/l
0.16
151
1183
28
130
2.36
3.82
9.2
10.7
11.3
12.1
kpa
0.45
28
125
28
130
2.36
3.82
9.2
10.7
5.4
5.2
kpa
0.30
28
124
60
377
1.88
3.70
3.9
3.5
7.9
7.9
mg/mmol
0.00
42
215
11
30
3.84
3.70
1.7
1.2
—
—
—
0
0
62
394
1.87
3.69
3.2
2.8
8.2
7.5
mmol/l
0.53
51
333
64
411
1.86
3.68
7.2
2.9
25.6
60.1
e6/l
0.92
44
313
25
113
2.40
3.61
14.8
3.7
—
—
—
0
0
22
94
2.52
3.57
3.0
3.9
67.5
72.1
e9/l
0.20
13
74
6
6
10.28
3.52
2.3
1.5
122.3
152.7
nmol/l
—
6
6
130
1047
1.83
3.40
5.5
4.0
—
—
—
0
0
23
104
2.39
3.32
1.1
1.3
—
—
—
0
0
165
1448
2.42
3.29
7.6
4.8
41.0
38.8
mmol/mol
1.85
159
1364
167
1474
2.52
3.27
6.3
4.9
1.7
1.8
mu/l
0.65
162
1373
17
67
2.69
3.23
5.0
4.3
—
7.4
—
0
11
61
402
1.78
3.16
10.1
7.4
—
—
—
0
0
36
200
2.00
3.15
1.3
1.2
—
—
—
0
0
170
1526
2.61
2.95
5.2
4.1
6.0
5.7
mmol/l
1.68
165
1421
55
360
1.75
2.88
1.3
1.2
0.6
2.7
u/ml
0.91
15
94
183
1757
+∞
2.85
32.7
18.0
30.3
30.3
pg
0.07
183
1740
183
1757
+∞
2.85
32.8
18.0
91.4
91.0
fl
0.58
183
1740
33
186
1.94
2.76
2.4
2.0
—
—
—
0
0
63
434
1.69
2.73
4.9
3.7
7.4
7.4
ph
—
8
88
73
523
1.66
2.73
5.4
3.4
2.4
2.4
mmol/l
0.20
68
464
50
326
1.73
2.64
1.4
1.3
38.7
31.2
iu/ml
0.12
22
115
7
16
4.50
2.50
1.4
1.3
—
—
—
0
0
112
907
1.61
2.46
14.6
9.8
4.2
3.9
e9/l
0.67
102
801
34
203
1.83
2.39
1.3
1.9
148.5
126.6
ug/g
0.14
25
164
15
65
2.42
2.38
1.2
1.3
—
—
—
0
0
5
8
6.39
2.38
8.8
3.5
14.1
7.4
mu/l
—
5
8
27
150
1.94
2.36
1.4
1.4
—
—
—
0
0
25
136
1.97
2.32
1.2
1.2
100.3
190.3
iu/ml
—
6
60
139
1198
1.67
2.27
5.8
3.9
14.5
10.2
mm/h
2.08
134
1116
166
1508
2.09
2.24
4.7
3.8
1.4
1.2
mmol/l
2.75
159
1403
15
68
2.31
2.17
3.6
4.5
24.8
25.7
mmol/l
0.27
15
68
48
327
1.63
2.12
1.4
1.3
6.1
7.4
u/ml
0.08
21
126
44
294
1.65
2.09
6.0
2.4
7.2
8.3
e6/l
0.15
39
262
47
326
1.59
1.92
2.3
1.3
2.2
2.2
g/l
0.19
35
194
26
154
1.80
1.88
1.5
1.8
—
—
—
0
0
8
28
2.94
1.88
36.4
2.9
—
—
—
0
0
6
17
3.61
1.85
2.7
1.9
—
—
—
0
0
5
12
4.25
1.83
1.0
3.8
—
—
—
0
0
169
1566
2.04
1.81
5.0
4.2
1.4
1.6
mmol/l
7.52
163
1464
55
403
1.52
1.76
2.8
3.3
—
—
—
0
0
6
18
3.41
1.76
1.7
1.2
—
—
—
0
0
11
48
2.37
1.74
4.5
4.5
—
—
—
0
0
160
1462
1.75
1.74
26.5
12.6
39.6
40.1
%
0.33
123
1158
7
24
2.99
1.74
1.0
1.0
—
—
—
0
0
21
120
1.85
1.71
1.6
1.3
23.8
30.7
iu/l
0.55
21
103
58
434
1.49
1.67
1.6
1.7
1.4
1.4
mmol/l
0.36
52
373
6
19
3.23
1.67
1.0
1.2
—
—
—
0
0
5
14
3.64
1.62
1.6
1.3
11.8
28.2
umol/l
—
5
14
20
115
1.83
1.60
2.4
4.8
0.0
0.3
%
—
6
33
10
44
2.35
1.56
1.4
1.2
—
—
—
0
0
5
15
3.40
1.53
1.0
1.1
—
—
—
0
0
6
21
2.92
1.52
1.7
1.4
—
—
—
0
0
92
763
1.41
1.51
4.4
3.4
0.0
0.0
estimate
0.00
11
162
93
775
1.41
1.48
4.5
3.4
0.0
0.0
estimate
0.50
13
159
9
38
2.44
1.48
1.2
1.3
—
—
—
0
0
21
126
1.75
1.48
2.4
4.6
0.6
1.1
%
—
6
38
149
1354
1.54
1.46
29.6
14.8
14.2
13.6
%
2.10
149
1334
5
16
3.18
1.44
5.2
7.6
—
—
—
0
0
170
1600
1.88
1.39
5.7
4.6
2.8
2.9
mmol/l
0.56
164
1493
6
23
2.66
1.38
48.2
1.9
54.8
56.1
%
—
6
23
6
23
2.66
1.38
10.0
2.6
—
—
—
0
0
5
17
2.99
1.37
5.4
2.8
—
—
—
0
0
25
162
1.63
1.35
1.8
1.5
—
—
—
0
0
44
325
1.47
1.34
4.3
3.6
1.0
1.0
kg/l
0.49
13
34
83
690
1.37
1.29
14.5
8.6
0.0
0.0
e9/l
0.23
71
561
13
70
1.92
1.27
24.0
2.2
1.0
1.2
%
0.61
13
70
8
36
2.28
1.26
1.0
1.2
—
—
—
0
0
6
25
2.45
1.25
1.0
1.4
—
—
—
0
0
8
37
2.21
1.23
2.1
19.1
1.7
1.0
mmol/l
—
8
32
44
336
1.41
1.12
4.9
3.4
—
—
—
0
0
12
203
0.56
1.11
1.3
1.3
—
—
—
0
0
5
21
2.42
1.10
1.4
1.2
—
—
—
0
0
12
67
1.85
1.07
1.3
1.5
—
—
—
0
0
89
768
1.31
1.01
6.7
4.6
0.0
0.0
estimate
0.00
15
161
35
263
1.41
0.98
2.0
1.7
—
—
—
0
0
6
27
2.26
0.94
1.3
1.6
—
—
—
0
0
52
421
1.33
0.92
1.6
1.4
—
—
—
0
0
18
120
1.55
0.89
2.6
4.9
—
—
—
0
0
79
680
1.28
0.89
2.3
1.9
—
—
—
0
0
12
75
1.64
0.77
8.8
10.9
—
—
—
0
0
29
221
1.37
0.76
1.8
1.5
—
—
—
0
0
7
39
1.83
0.73
1.0
1.1
4.1
3.9
mmol/l
—
7
34
5
25
2.03
0.73
1.2
1.6
—
—
—
0
0
7
40
1.78
0.72
1.0
1.4
—
—
—
0
0
171
1651
1.54
0.70
17.2
11.2
—
—
—
0
0
24
180
1.38
0.69
2.1
1.5
—
—
—
0
0
13
86
1.55
0.68
3.8
2.2
—
—
—
0
0
49
413
1.25
0.64
4.1
3.7
0.0
0.0
estimate
0.00
15
161
12
80
1.54
0.61
16.8
12.2
24.3
25.1
mmol/l
0.17
12
75
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
6
38
1.60
0.55
3.7
3.9
0.1
0.2
g/l
—
6
15
7
46
1.54
0.49
1.4
1.3
—
—
—
0
0
7
51
1.39
0.44
1.1
1.2
—
—
—
0
0
5
31
1.63
0.43
1.6
1.2
—
—
—
0
0
5
33
1.53
0.41
1.2
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
12
88
1.39
0.41
2.6
2.1
—
—
—
0
0
9
124
0.71
0.36
1.1
1.8
—
—
—
0
0
6
43
1.41
0.35
1.7
2.5
—
—
—
0
0
12
91
1.34
0.34
1.3
1.1
—
—
—
0
0
6
47
1.29
0.32
11.2
3.1
1.2
1.4
mmol/l
—
6
47
7
53
1.33
0.31
1.4
1.4
—
—
—
0
0
7
56
1.26
0.30
1.4
1.3
—
—
—
0
0
7
57
1.24
0.29
1.4
1.3
—
—
—
0
0
7
57
1.24
0.29
1.4
1.3
—
—
—
0
0
7
57
1.24
0.29
1.4
1.3
—
—
—
0
0
8
67
1.20
0.26
1.0
1.3
—
—
—
0
0
58
536
1.12
0.26
4.6
3.5
22.2
25.8
ng/l
0.25
36
336
43
391
1.13
0.25
5.7
4.7
—
—
—
0
0
69
646
1.11
0.24
3.1
2.6
—
—
—
0
0
16
134
1.21
0.23
2.6
2.4
—
8.3
—
0
5
5
37
1.36
0.23
9.0
2.4
—
—
—
0
0
49
453
1.11
0.22
3.6
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.9
—
—
—
0
0
16
136
1.19
0.21
1.5
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
20
174
1.17
0.20
1.4
1.4
—
—
—
0
0
9
115
0.77
0.20
4.4
3.5
1.2
1.2
mmol/l
—
9
104
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
52
1.16
0.19
13.2
3.9
—
—
—
0
0
12
102
1.19
0.15
1.3
1.4
—
—
—
0
0
14
122
1.16
0.14
1.4
1.3
—
30.1
—
0
6
13
148
0.87
0.13
1.4
1.2
—
—
—
0
0
10
85
1.19
0.12
1.2
1.2
—
—
—
0
0
6
57
1.05
0.08
1.5
3.0
—
—
—
0
0
8
76
1.06
0.07
1.1
1.1
—
—
—
0
0
17
157
1.09
0.07
5.1
4.4
7.3
7.1
ug/l
0.01
11
123
14
128
1.10
0.07
1.5
1.5
—
—
—
0
0
20
188
1.07
0.06
1.5
1.3
—
—
—
0
0
13
138
0.94
0.02
2.9
3.5
—
—
—
0
0
11
103
1.07
0.02
2.0
1.4
—
—
—
0
0
14
144
0.97
0.00
1.9
2.5
0.7
0.7
ug/l
—
8
78
14
139
1.01
0.00
1.6
1.7
—
—
—
0
0
12
115
1.05
0.00
3.6
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
7.6
—
0
8
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
57
0.87
0.00
1.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
10.2
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
2.7
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
20.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_LOCALADIP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_LOCALADIP.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_LOCALADIP – Localized adiposity

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data