testicular disease: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
151 |
4. Check minimum number of eventsNone |
151 |
5. Include endpointsNone |
151 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Testicular dysfunction, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Testicular dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1111 | - | 1111 |
| Only index persons | 1058 | - | 1058 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | - | 0.03 |
| Only index persons | 0.04 | - | 0.04 |
| Median age at first event (years) | |||
| Whole population | - | - | 39.11 |
| Only index persons | - | - | 39.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | - | 151 |
| Unadjusted period prevalence (%) | 0.07 | - | 0.07 |
| Median age at first event (years) | 50.45 | - | 50.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 131
- Matched controls
- 1309
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E29.9
ICD-10 Finland
Testicular dysfunction, unspecified
1144.5
98.2
84
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
38.2
56.8
75
44
E29.8
ICD-10 Finland
Other testicular dysfunction
+∞
51.5
46
*
E29.1
ICD-10 Finland
Testicular hypofunction
58.1
21.0
24
5
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
123.9
20.2
21
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
11.6
11
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
59.5
9.8
11
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
12.0
9.6
17
16
Y28
ICPC
Limited function/disability (Y)
35.8
8.2
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.9
7.0
29
88
N02AX02
ATC
tramadol; systemic, rectal
2.7
6.9
65
348
A50
ICPC
General and Unspecified, Medication/prescr/renewal
13.2
6.7
11
9
N03AX16
ATC
pregabalin; oral
3.3
6.6
36
135
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3009214) Lutropin [Units/volume] in Serum or Plasma
47
49
13.47
42.69
2.3
1.5
u/l
6.1
4.2
1.27
40
40
(3018301) Testosterone Free [Moles/volume] in Serum or Plasma
21
30
7.97
14.38
2.5
1.3
pmol/l
36.6
53.6
—
5
8
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
17
8
23.72
12.32
1.4
1.4
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
114
698
3.58
10.91
4.3
4.1
ug/l
1.4
1.7
1.36
108
638
(3039443) Prostate specific Ag panel - Serum or Plasma
24
53
5.20
10.67
2.0
1.3
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
133
963
4.20
8.49
4.1
3.6
mu/l
1.8
2.0
0.95
123
885
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
93
560
2.72
8.15
4.1
3.8
%
28.3
20.7
2.05
32
228
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
110
745
2.75
7.24
3.6
2.9
pmol/l
14.9
14.8
0.17
104
674
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
72
406
2.48
6.91
2.8
2.7
ug/l
0.7
0.7
0.03
36
233
(40760892) CBC W Ordered Manual Differential panel - Blood
53
261
2.59
6.75
2.8
5.5
—
—
—
0
0
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
23
74
3.49
6.20
7.6
2.3
ml/min/173m2
63.1
66.0
—
9
34
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
28
105
3.05
5.90
8.4
8.7
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
25
94
2.99
5.23
1.6
1.3
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
82
557
2.03
4.40
4.3
6.8
e9/l
0.6
0.6
0.93
73
487
(3006315) Basophils [#/volume] in Blood
82
559
2.02
4.33
4.3
6.8
e9/l
0.0
0.0
0.25
73
493
(3031040) Bacteria [#/volume] in Urine by Automated count
85
587
2.03
4.33
4.3
3.4
—
9.7
—
0
7
(3013115) Eosinophils [#/volume] in Blood
83
569
2.02
4.31
4.4
7.5
e9/l
0.2
0.2
2.23
74
511
(3019198) Lymphocytes [#/volume] in Blood
83
575
1.98
4.12
4.3
6.9
e9/l
1.8
1.8
0.22
75
517
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
64
405
2.01
4.12
2.7
3.1
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
95
696
1.98
3.95
3.5
3.8
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
75
509
1.94
3.89
3.5
4.2
estimate
0.0
0.0
0.00
16
91
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
60
378
1.97
3.86
3.1
2.8
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
36
190
2.17
3.71
2.3
2.1
mg/l
3.1
3.3
0.23
31
167
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
30
147
2.30
3.68
2.4
1.7
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
75
516
1.90
3.67
2.7
3.1
estimate
0.0
0.0
0.00
14
84
(3035350) Ketones [Presence] in Urine by Test strip
74
509
1.89
3.61
2.8
3.0
estimate
0.0
0.0
0.00
15
90
(3035637) Corticotropin [Mass/volume] in Plasma
8
13
6.43
3.55
1.1
1.1
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
51
313
1.95
3.48
3.7
2.6
e6/l
85.2
76.3
0.04
41
239
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
110
868
1.98
3.45
7.4
8.1
u/l
77.9
77.1
0.05
104
832
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
63
418
1.87
3.39
5.3
3.3
ng/l
24.4
33.8
0.50
44
273
(36304419) Bacteria [Presence] in Urine
46
275
1.97
3.38
3.1
2.5
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
49
305
1.90
3.17
2.7
2.5
umol/l
399.1
8907.5
1.55
43
269
(40761511) CBC panel - Blood by Automated count
142
1275
2.91
3.16
15.3
11.7
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
18
75
2.59
3.11
2.3
2.4
—
23.0
—
0
8
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
137
1194
2.59
3.04
16.3
12.7
mg/l
26.8
23.3
0.51
109
936
(3041096) Erythrocytes [Presence] in Urine by Automated
47
293
1.88
3.01
2.5
2.7
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
17
71
2.57
2.92
1.3
1.2
—
14.3
—
0
6
(3009508) Creatinine [Moles/volume] in Urine
55
364
1.80
2.90
5.4
3.4
mmol/l
9.2
8.9
0.14
50
324
(40761535) Cells panel - Urine sediment
19
85
2.41
2.84
3.3
3.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
63
437
1.76
2.82
3.6
4.3
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
53
350
1.79
2.80
4.0
3.1
e6/l
24.4
201.4
0.85
43
252
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
38
227
1.90
2.75
1.8
1.7
mg/l
0.8
1.7
1.34
30
175
(3029937) Albumin [Presence] in Urine by Test strip
43
268
1.85
2.73
3.3
3.2
estimate
0.0
0.0
0.49
16
86
(3013512) EKG study
45
285
1.82
2.72
3.6
3.6
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
26
136
2.10
2.71
2.7
2.0
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
129
1113
2.09
2.66
13.8
11.3
ml/min/173m2
84.6
89.0
1.31
111
928
(3012544) pH of Venous blood
21
102
2.23
2.62
2.5
3.9
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
84
642
1.70
2.58
7.2
10.3
e9/l
4.1
4.2
0.14
76
572
(3020682) Albumin/Creatinine [Ratio] in Urine
49
325
1.75
2.52
3.6
4.2
mg/mmol
3.7
8.5
1.43
36
229
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
7
16
4.53
2.50
1.1
1.1
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
71
523
1.67
2.48
3.2
2.6
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
65
468
1.68
2.47
5.8
8.6
mmol/l
1.2
1.2
0.38
57
400
(3012516) Albumin [Mass/volume] in Urine
46
303
1.75
2.41
3.2
3.5
mg/l
31.2
272.3
0.58
32
206
(3025941) Bacteria identified in Stool by Culture
14
59
2.51
2.37
1.4
1.2
—
—
—
0
0
(3026782) Osmolality of Urine
33
198
1.85
2.34
2.9
2.5
mosm/kgh2o
552.2
600.0
0.59
27
166
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
27
152
1.95
2.31
2.8
2.1
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
50
341
1.70
2.30
2.0
1.8
pmol/l
94.9
94.5
0.02
31
193
(3044889) 12 lead EKG panel
98
795
1.66
2.28
4.1
3.6
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
35
216
1.81
2.27
1.5
1.5
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
38
242
1.76
2.22
2.1
1.9
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
16
77
2.21
2.05
1.6
1.9
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
37
241
1.71
1.99
1.3
1.3
u/ml
0.7
0.8
0.50
12
74
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
32
202
1.74
1.92
3.6
3.7
ng/l
6624.8
285.3
0.47
23
159
(3021589) Normoblasts [#/volume] in Blood
65
492
1.56
1.91
9.6
9.2
e9/l
0.0
0.0
1.21
55
404
(3030467) Casts [#/volume] in Urine by Automated count
42
286
1.65
1.91
3.9
2.5
e6/l
0.5
0.5
0.01
31
212
(3005322) IgE [Units/volume] in Serum or Plasma
13
59
2.32
1.90
1.4
1.2
u/ml
285.0
241.4
0.07
13
52
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
35
228
1.70
1.88
1.9
2.5
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
58
431
1.56
1.84
4.7
7.5
mmol/l
1.2
1.2
0.01
51
396
(3013707) Erythrocyte sedimentation rate by Westergren method
94
778
1.55
1.82
3.8
3.6
mm/h
8.8
9.2
0.09
86
734
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
127
1133
1.76
1.77
4.3
4.2
mmol/l
6.1
6.0
0.29
115
1059
(4306422)
6
18
3.43
1.76
1.2
1.6
—
—
—
0
0
(3000991) Gas panel - Venous blood
18
98
1.95
1.70
4.2
10.3
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
12
228
0.49
1.63
1.3
1.5
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
20
116
1.83
1.58
3.0
4.8
u/l
211.4
247.1
1.03
20
111
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
136
1248
1.90
1.57
5.5
4.5
mmol/l
2.7
2.8
0.65
130
1177
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
25
156
1.72
1.56
1.2
1.2
iu/ml
10.1
20.5
—
9
46
(3007164) IgA [Mass/volume] in Serum or Plasma
33
223
1.61
1.54
1.3
1.4
g/l
2.3
2.6
0.57
24
157
(3018418) pH of Serum or Plasma
39
275
1.56
1.52
3.8
3.9
ph
7.4
7.4
—
9
47
(3015377) Calcium [Moles/volume] in Serum or Plasma
41
295
1.54
1.46
3.9
3.3
mmol/l
2.3
2.3
0.08
35
264
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
101
871
1.48
1.45
3.1
3.1
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
22
2.80
1.45
1.3
1.4
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
134
1233
1.77
1.41
5.1
4.1
mmol/l
1.2
1.3
1.11
127
1163
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
30
203
1.60
1.39
1.6
1.7
pmol/l
434.4
424.1
0.07
25
176
(3020891) Body temperature
10
47
2.21
1.37
8.8
4.9
—
—
—
0
0
(3015736) pH of Urine
51
390
1.46
1.35
2.3
3.1
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
39
283
1.51
1.33
3.2
3.2
ng/l
1138.4
783.5
0.40
33
230
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
21
131
1.70
1.32
1.8
1.9
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
20
123
1.72
1.32
4.0
4.1
%
27.3
28.8
0.22
12
91
(1616796) Gas panel - Central venous blood
6
24
2.56
1.31
2.5
2.5
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
25
165
1.62
1.28
2.5
2.5
e6/l
0.4
0.3
0.01
12
88
(40768804) Tissue Pathology biopsy report
46
351
1.45
1.22
2.0
1.9
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
12
64
1.95
1.22
2.7
1.2
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
133
1233
1.66
1.20
5.1
4.2
mmol/l
4.5
4.6
0.91
126
1171
(3011397) Hemoglobin [Presence] in Urine by Test strip
32
228
1.51
1.19
2.6
3.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
20
127
1.66
1.19
1.7
1.8
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
33
237
1.50
1.18
3.3
3.4
kg/l
1.0
1.0
—
5
28
(36660697) Celiac disease serology panel - Serum
14
80
1.83
1.17
1.0
1.2
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
8
39
2.11
1.17
1.9
2.2
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
5
20
2.55
1.16
1.2
1.6
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
40
302
1.44
1.12
1.9
2.5
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
5
21
2.43
1.10
1.2
1.3
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
22
2.31
1.04
1.6
1.7
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
55
445
1.37
1.03
5.0
5.6
g/l
36.9
37.0
0.07
50
425
(3009542) Hematocrit [Volume Fraction] of Blood
129
1198
1.53
1.03
12.9
12.9
%
44.2
42.4
2.73
104
974
(3003694) ABO and Rh group [Type] in Blood
38
289
1.42
1.02
1.5
1.3
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
17
108
1.65
1.02
1.2
1.4
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
22
150
1.55
1.00
2.3
2.4
umol/l
15.7
14.9
0.18
22
139
(3047181) Lactate [Moles/volume] in Blood
0
29
0.00
0.99
0.0
22.9
—
1.2
—
0
23
(3028707) Methadone [Presence] in Urine by Screen method
7
36
1.99
0.98
12.1
4.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
24
170
1.49
0.92
2.3
2.9
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
6
28
2.19
0.92
1.8
3.2
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
8
42
1.95
0.90
4.3
2.7
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
8
42
1.95
0.90
2.0
2.9
—
—
—
0
0
(4034850)
8
43
1.91
0.89
8.9
14.7
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
11
64
1.78
0.89
30.0
3.3
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
25
183
1.44
0.83
1.3
1.8
—
—
—
0
0
(3022145) Colonoscopy Study observation
17
115
1.54
0.81
1.5
1.4
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
106
967
1.32
0.81
3.7
3.5
u/l
56.1
53.4
0.13
99
923
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
33
1.85
0.80
1.3
1.7
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
25
0.00
0.80
0.0
5.3
—
—
—
0
0
(3020191) Ethanol [Moles/volume] in Serum or Plasma
0
25
0.00
0.80
0.0
1.7
—
1.3
—
0
19
(3039000) Anion gap in Blood
0
26
0.00
0.79
0.0
23.9
—
11.9
—
0
21
(3018572) Chloride [Moles/volume] in Blood
0
26
0.00
0.79
0.0
23.9
—
104.1
—
0
21
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
128
1203
1.42
0.78
4.9
3.8
mmol/l
1.4
1.4
0.12
121
1141
(4094501)
6
34
1.80
0.77
1.0
1.1
—
—
—
0
0
(3022621) pH of Urine by Test strip
9
53
1.74
0.77
3.9
1.8
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
7
38
1.88
0.74
2.0
2.8
—
—
—
0
0
(3019060) Gas panel - Arterial blood
12
76
1.63
0.74
6.0
10.8
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
19
135
1.47
0.73
1.2
1.2
u/ml
1.1
6.9
1.12
12
58
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
5
25
2.03
0.73
1.0
1.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
38
306
1.32
0.72
4.4
4.5
—
—
—
0
0
(3012501) Base excess in Blood by calculation
5
26
1.95
0.71
3.0
2.1
mmol/l
2.6
2.5
—
5
15
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
5
26
1.95
0.71
1.0
2.7
—
—
—
0
0
(3000492) Spirometry study
10
154
0.62
0.68
1.2
1.4
—
—
—
0
0
(1002224) Polysomnography panel
12
78
1.58
0.68
1.1
1.1
—
—
—
0
0
(3016502) Oxygen saturation in Arterial blood
16
112
1.48
0.67
7.2
15.1
%
95.6
96.1
0.23
16
106
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
24
182
1.38
0.66
2.8
2.3
e6/l
0.3
1.0
—
10
106
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
23
298
0.73
0.66
1.5
1.7
mmol/l
1.6
1.5
0.21
18
253
(3032080) INR in Blood by Coagulation assay
51
433
1.27
0.65
9.2
9.0
inr
1.1
1.3
3.11
20
127
(3014765) Yersinia sp identified in Stool by Organism specific culture
5
29
1.75
0.64
1.6
1.1
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
5
29
1.75
0.64
1.6
1.1
—
—
—
0
0
(4035726)
11
71
1.59
0.64
1.3
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
18
131
1.42
0.62
2.1
1.6
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
5
30
1.69
0.62
1.6
1.1
—
—
—
0
0
(3014148) Varicella zoster virus Ab [Titer] in Serum
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
20
0.00
0.61
0.0
3.6
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
21
0.00
0.60
0.0
24.4
—
1169.5
—
0
21
(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood
0
23
0.00
0.59
0.0
2.5
—
510.4
—
0
10
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
8
54
1.51
0.58
1.0
1.6
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
23
178
1.34
0.57
1.7
1.6
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
23
178
1.34
0.57
1.9
2.0
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
12
82
1.50
0.56
2.9
3.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
33
271
1.28
0.55
9.0
6.2
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
43
365
1.25
0.55
4.5
6.7
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
13
92
1.45
0.52
7.2
2.3
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
11
75
1.50
0.52
2.7
1.5
—
—
—
0
0
(3002256) Pathology report gross observation
15
110
1.40
0.51
1.3
1.2
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
16
120
1.37
0.48
1.3
1.3
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
8
56
1.45
0.43
1.5
1.3
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
13
96
1.39
0.43
7.4
2.3
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
5
32
1.58
0.42
1.4
1.3
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
5
32
1.58
0.42
2.2
1.7
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
16
123
1.34
0.42
1.4
1.8
—
—
—
0
0
(3010421) pH of Blood
5
33
1.53
0.41
3.4
2.0
ph
7.4
7.4
—
5
25
(3020961) Endomysium IgA Ab [Titer] in Serum
8
59
1.38
0.41
1.0
1.2
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
16
0.00
0.41
0.0
3.1
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
13
97
1.37
0.41
7.2
2.3
—
—
—
0
0
(3013180) HIV 1 RNA [Units/volume] (viral load) in Serum or Plasma by Probe with amplification
0
17
0.00
0.41
0.0
10.8
—
52.9
—
0
8
(3027008) Opiates [Presence] in Urine
13
98
1.36
0.39
7.3
2.3
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
13
98
1.36
0.39
7.4
2.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
17
134
1.30
0.39
3.1
1.5
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
9
67
1.36
0.39
1.4
1.5
g/l
0.7
1.3
—
9
62
(3045414) Leukocytes [Presence] in Urine
5
36
1.40
0.38
1.6
1.5
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
9
69
1.32
0.38
2.6
3.5
ng/l
344.7
190.5
—
9
62
(1001926) Buprenorphine [Presence] in Urine by Screen method
10
72
1.42
0.38
9.0
2.6
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
6
45
1.35
0.34
1.7
1.5
—
—
—
0
0
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
7
98
0.70
0.32
2.3
2.9
g/l
0.2
0.2
—
7
93
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
7
52
1.36
0.31
1.1
1.0
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
8
62
1.31
0.28
1.9
2.4
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
19
159
1.22
0.28
2.3
2.2
—
—
—
0
0
(4010399)
11
86
1.30
0.27
1.2
1.4
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
11
86
1.30
0.27
4.8
5.9
—
0.1
—
0
27
(3019309) Folate [Moles/volume] in Red Blood Cells
18
151
1.22
0.26
2.1
1.7
nmol/l
1066.4
1224.2
0.26
11
122
(3008152) Bicarbonate [Moles/volume] in Arterial blood
9
75
1.21
0.25
15.3
14.6
mmol/l
26.4
24.1
—
9
67
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
9
76
1.20
0.25
1.7
1.7
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
13
106
1.25
0.24
8.0
15.9
g/l
133.3
126.7
0.64
13
100
(3019225) pH of Specimen
10
79
1.28
0.23
1.9
4.1
—
—
—
0
0
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
5
40
1.26
0.22
2.4
18.2
%
1.5
1.7
—
5
35
(3007930) Methemoglobin/Hemoglobin.total in Blood
5
40
1.26
0.22
2.4
18.2
%
0.7
0.9
—
5
35
(3002179) Metamyelocytes/100 leukocytes in Blood
11
89
1.25
0.21
3.3
5.2
—
0.5
—
0
24
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
11.9
—
0.6
—
0
11
(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3037556) Urate [Mass/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
5.0
—
2.7
—
0
10
(3032773) Endomysium IgG Ab [Titer] in Serum
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3006922) Hepatitis E virus Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3000093) Morphology [Interpretation] in Blood Narrative
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3017315) Amylase [Enzymatic activity/volume] in Urine
0
10
0.00
0.21
0.0
1.4
—
320.7
—
0
10
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3015183) Erythrocyte sedimentation rate
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
18
156
1.17
0.19
1.3
1.4
—
—
—
0
0
(3021440) Promyelocytes/100 leukocytes in Blood
11
93
1.20
0.15
4.8
5.7
—
0.3
—
0
31
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
48
1.04
0.09
3.0
2.9
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
6
56
1.07
0.09
1.2
1.3
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
11
100
1.11
0.05
4.8
5.5
—
0.9
—
0
35
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
111
0.99
0.00
4.0
2.9
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3041806) Other cells [#/volume] in Blood by Manual count
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3017704) Immunofixation for Urine
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3044007) Cell count panel - Peritoneal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
2.7
—
1000.7
—
0
9
(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(3035947) Staphylolysin Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024932) HLA-DR beta [Type]
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum
0
7
0.00
0.00
0.0
3.1
—
121.6
—
0
7
(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
1111.7
—
0
6
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009871) Measles virus Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(40768446) Kidney Pathology biopsy report
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3014271) Vancomycin [Susceptibility]
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3042733) HLA Ab [Presence] in Serum
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.0
—
283.4
—
0
8
(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023487) Leukocytes [#/volume] in Peritoneal fluid
0
6
0.00
0.00
0.0
2.7
—
333.5
—
0
6
(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
6.8
—
—
—
0
0
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002222) Hepatitis E virus IgM Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3022313) Gas panel - Capillary blood
6
64
0.93
0.00
1.8
3.0
—
—
—
0
0
(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
6
59
1.02
0.00
2.2
1.7
—
—
—
0
0
(3035880) pH of Pleural fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4024509)
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758292) HTLV I+II Ab panel - Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
9
0.00
0.00
0.0
3.7
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
5
0.00
0.00
0.0
2.0
—
1649.0
—
0
5
(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(3022689) Creatine [Moles/volume] in Urine
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028679) Herpes simplex virus Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
137.2
—
0
5
(3022493) Free Hemoglobin [Mass/volume] in Plasma
0
5
0.00
0.00
0.0
2.8
—
52.4
—
0
5
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008536) Aspergillus sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(4133840)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008898) HLA-B27 [Presence]
5
49
1.02
0.00
1.2
1.0
—
—
—
0
0
(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.9
—
14.1
—
0
8
(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
0
9
0.00
0.00
0.0
3.1
—
—
—
0
0
(3020650) Glucose [Presence] in Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3024471) HLA-A [Type]
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
11.0
—
—
—
0
0
(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_TESTICDYSNAS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_TESTICDYSNAS | 1.564 [1.05, 2.32] | 0.026 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 694 males with E4_TESTICDYSNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_TESTICDYSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.294% |
| 5 | No data | 1.847% |
| 10 | No data | 4.324% |
| 15 | No data | 8.11% |
| 20 | No data | 13.644% |
Relationships between endpoints
↥Index endpoint: E4_TESTICDYSNAS – Testicular dysfunction, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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