Lumbosacral plexus disorders

G6_LSPLEX

peripheral nervous system disease: A disease involving the peripheral nervous system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G54.1 Hospital discharge: ICD-9 — 3531 Cause of death: ICD-10 — G54.1 Cause of death: ICD-9 — 3531 2 out of 7 registries used, show all original rules.	119
4. Check minimum number of events None	119
5. Include endpoints None	119
6. Filter based on genotype QC (FinnGen only)	119

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G54
Name in latin: Morbositates plexus lumbosacralis

NAME	G6_LSPLEX
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G541
HD_ICD_9	3531
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G541
COD_ICD_9	3531
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lumbosacral plexus disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	903	486	412
Only index persons	807	435	372
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	56.12	55.89	56.21
Only index persons	54.07	54.21	53.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	119	71	48
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	54.91	52.61	58.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
103: Matched controls
1030

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G54.1

ICD-10 Finland

Lumbosacral plexus disorders

+∞

133.3

N03AX16

ATC

pregabalin; oral

9.4

23.4

137

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

9.6

17.6

N03AX12

ATC

gabapentin; oral

8.2

16.4

N02AX02

ATC

tramadol; systemic, rectal

5.9

15.9

290

M48.0

ICD-10 Finland

Spinal stenosis

9.2

14.5

M54.4

ICD-10 Finland

Lumbago with sciatica

7.1

14.3

N06AA09

ATC

amitriptyline; systemic

9.2

13.3

G56.0

ICD-10 Finland

Carpal tunnel syndrome

15.2

12.3

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

9.6

12.1

ACC51

NOMESCO Finland

Release of median nerve

73.5

11.9

XA402

NOMESCO Finland

ENMG

20.7

11.1

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

+∞

10.6

M54.5

ICD-10 Finland

Low back pain

4.1

9.9

194

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.3

9.7

M54.9

ICD-10 Finland

Dorsalgia, unspecified

6.4

9.3

M54.1

ICD-10 Finland

Radiculopathy

16.0

9.0

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

9.9

8.7

N06AX21

ATC

duloxetine; oral

6.1

8.6

N02AA05

ATC

oxycodone; systemic

4.9

8.6

G54.0

ICD-10 Finland

Brachial plexus disorders

97.7

8.5

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

7.0

7.8

M79.6

ICD-10 Finland

Pain in limb

3.4

7.8

231

AA1AD

NOMESCO Finland

CT of head and brain

3.7

7.6

146

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.2

7.4

313

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

5.5

6.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.9

6.6

WX308

NOMESCO Finland

Sacral anesthesy

74.3

6.5

R51.80

ICD-10 Finland

Headache

4.4

6.3

3531A

ICD-9 Finland

Nerve root and plexus disorders, Lumbosacral plexus lesions

+∞

6.3

M96.1

ICD-10 Finland

Postlaminectomy syndrome, not elsewhere classified

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

447

3.28

8.75

5.1

5.5

1.2

mmol/l

0.26

380

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

424

2.97

7.64

4.7

3.8

—

(3003396) Base excess in Arterial blood by calculation

3.59

7.44

3.9

6.5

1.0

1.2

mmol/l

0.10

(3013115) Eosinophils [#/volume] in Blood

471

2.90

7.12

6.2

5.9

0.2

e9/l

0.02

411

(42870588) Differential panel, method unspecified - Blood

290

2.76

6.80

6.8

5.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

545

2.96

6.79

8.2

9.2

3.9

4.0

e9/l

0.15

481

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

361

2.67

6.48

4.9

3.5

45.8

34.8

ng/l

0.22

242

(3006315) Basophils [#/volume] in Blood

459

2.71

6.42

6.3

5.4

0.0

e9/l

0.16

394

(3019198) Lymphocytes [#/volume] in Blood

464

2.67

6.20

6.4

5.5

1.9

2.1

e9/l

0.53

411

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

418

2.55

5.84

5.6

4.8

1.2

mmol/l

0.33

378

(3032080) INR in Blood by Coagulation assay

362

2.49

5.62

6.3

6.0

1.3

1.2

inr

0.47

105

(3023368) Bacteria identified in Blood by Culture

234

2.57

5.58

5.3

4.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

715

3.10

5.53

3.4

3.7

15.0

14.7

pmol/l

0.62

637

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

210

2.55

5.24

2.9

2.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

160

2.68

5.23

1.5

1.3

2.0

7.1

u/ml

1.03

(3004588) Protein electrophoresis panel - Serum or Plasma

3.54

5.00

1.3

1.2

—

(3026008) Bacteria identified in Urine by Culture

287

2.36

4.85

3.4

2.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.91

4.35

3.1

3.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

169

2.42

4.19

1.5

1.3

12.5

31.8

iu/ml

—

(3044640) Blood type and Crossmatch panel - Blood

286

2.21

4.15

2.9

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

380

2.17

4.14

2.5

2.3

80.6

76.4

nmol/l

0.47

337

(3044889) 12 lead EKG panel

663

2.36

4.05

4.0

3.8

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

105

2.61

3.84

2.3

2.7

4.0

8.7

umol/l

1.65

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

294

2.13

3.82

2.6

2.4

47.3

56.0

u/l

1.48

274

(3019060) Gas panel - Arterial blood

3.03

3.77

4.0

4.6

—

(3017181) Myelocytes/100 leukocytes in Blood

2.87

3.77

1.9

4.1

1.3

1.4

—

(3018418) pH of Serum or Plasma

272

2.13

3.70

3.4

7.4

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.90

3.67

1.9

4.2

0.0

0.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

651

2.16

3.47

5.9

4.0

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

397

1.96

3.23

3.5

4.3

33.6

35.8

g/l

1.92

376

(3016018) Differential panel - Cerebral spinal fluid

6.68

3.23

1.9

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.31

3.19

4.8

7.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

390

1.95

3.17

3.3

2.6

124.1

113.2

ug/l

0.17

358

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.76

2.92

3.5

3.0

5.2

5.0

kpa

0.36

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.86

2.91

3.7

3.1

2.0

1.4

mmol/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

104

877

2.47

2.83

4.6

4.5

2.0

1.9

mu/l

0.07

793

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

110

965

2.85

2.82

22.1

12.7

21.6

22.9

mg/l

0.16

751

(3015736) pH of Urine

357

1.87

2.80

4.0

3.2

—

(40761535) Cells panel - Urine sediment

2.47

2.77

3.1

3.7

—

(3025159) Blasts/100 leukocytes in Blood

2.60

2.77

1.8

4.1

0.0

0.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

371

1.83

2.64

2.3

1.9

94.4

93.6

pmol/l

0.05

191

(3044290) Cell count panel - Cerebral spinal fluid

4.21

2.62

1.9

1.1

—

(3021589) Normoblasts [#/volume] in Blood

420

1.80

2.55

8.7

0.0

e9/l

0.51

341

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

342

1.80

2.44

5.7

3.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

122

2.10

2.37

1.7

2.1

21.8

24.1

0.23

108

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

208

1.89

2.36

3.0

2.0

3.1

3.3

mg/l

0.26

179

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.26

2.31

2.1

2.2

0.2

g/l

0.73

(3000991) Gas panel - Venous blood

2.42

2.29

3.5

6.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

140

1.99

2.23

2.2

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

470

1.72

2.22

4.5

3.5

0.0

estimate

0.00

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.45

2.18

1.2

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

5.16

2.09

2.2

4.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.15

2.08

1.6

—

(3012544) pH of Venous blood

2.25

2.08

1.7

3.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.15

2.06

1.3

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

477

1.68

2.05

6.0

4.6

0.0

estimate

0.00

(3009261) Glucose [Presence] in Urine by Test strip

480

1.66

1.98

4.5

3.5

0.0

estimate

0.00

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

180

1.81

1.90

3.9

3.4

2569.8

196.1

ng/l

0.45

134

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.64

1.89

4.8

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.03

1.83

1.8

1.6

—

(3042936) Bacteria identified in Isolate by Culture

142

1.86

1.82

2.6

1.8

—

(3029937) Albumin [Presence] in Urine by Test strip

260

1.68

1.77

4.4

3.9

0.0

estimate

0.00

(36304419) Bacteria [Presence] in Urine

260

1.68

1.77

5.4

2.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.99

1.73

1.7

1.5

—

(3045414) Leukocytes [Presence] in Urine

2.51

1.73

2.5

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

370

1.61

1.70

4.6

3.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.96

1.68

1.8

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.91

1.67

1.4

1.1

—

(3023410) Appearance of Cerebral spinal fluid

3.68

1.63

2.4

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.68

1.63

1.2

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

287

1.59

1.52

5.6

3.2

34.8

270.0

e6/l

0.54

225

(3014051) Protein [Presence] in Urine by Test strip

2.95

1.52

3.0

1.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

111

1028

2.19

1.50

24.3

14.9

75.6

76.0

umol/l

0.05

111

1028

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

101

902

1.79

1.47

6.1

5.4

40.6

39.6

mmol/mol

0.56

839

(3022313) Gas panel - Capillary blood

2.41

1.46

5.1

3.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.50

1.41

1.1

2.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

265

1.58

1.41

2.9

3.0

1283.7

1291.2

ng/l

0.01

213

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.69

1.38

1.2

1.1

0.0

g/l

—

(40758558) Short blood count panel - Blood

250

1.57

1.34

7.6

7.3

—

(3016879) Cocaine [Presence] in Urine

2.58

1.32

1.3

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.13

1.30

2.2

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.13

1.30

2.8

2.5

0.6

0.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.85

1.30

3.4

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.18

1.21

1.3

1.1

—

(40768804) Tissue Pathology biopsy report

403

1.46

1.21

2.1

—

(3000764) Benzodiazepines [Presence] in Urine

2.37

1.20

1.3

1.1

—

(3028300) Cannabinoids [Presence] in Urine

2.37

1.20

1.3

1.1

—

(3027008) Opiates [Presence] in Urine

2.37

1.20

1.3

1.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.37

1.20

1.2

2.2

24.0

24.2

mmol/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.37

1.20

1.2

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.99

1.16

2.0

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

214

1.54

1.15

5.1

3.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

206

1.54

1.13

3.4

4.7

—

(40761511) CBC panel - Blood by Automated count

109

1013

1.90

1.13

19.8

12.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.80

1.11

1.6

2.2

360.8

351.7

nmol/l

0.07

(3003694) ABO and Rh group [Type] in Blood

243

1.50

1.09

1.6

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.82

1.08

4.4

3.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.03

1.06

3.2

2.5

1.3

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

102

935

1.64

1.06

4.8

4.6

5.8

5.9

mmol/l

0.35

860

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.12

1.05

2.6

2.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

158

1.56

1.04

6.3

2.6

0.8

1.1

e6/l

0.48

(3000330) Specific gravity of Urine by Test strip

1.95

1.03

3.9

3.5

—

(3012516) Albumin [Mass/volume] in Urine

264

1.46

1.03

3.5

2.9

4874.9

53.5

mg/l

0.83

167

(3018095) Leukocytes [#/volume] in Urine

338

1.43

1.02

5.9

3.8

30.5

71.7

e6/l

1.14

244

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

907

1.54

0.97

17.5

12.3

81.8

80.2

ml/min/173m2

0.35

752

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.95

0.95

3.1

2.2

—

(3020891) Body temperature

1.95

0.95

8.0

4.2

—

(3027944) Amphetamines [Presence] in Urine

2.29

0.95

1.3

1.1

—

(3013512) EKG study

282

1.40

0.86

3.8

3.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.92

0.83

3.0

2.4

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.75

0.82

5.0

2.7

31.5

42.1

u/l

—

(3002256) Pathology report gross observation

115

1.56

0.82

1.6

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

284

1.38

0.82

4.6

3.6

14.3

7.0

mg/mmol

0.35

171

(3019309) Folate [Moles/volume] in Red Blood Cells

167

1.47

0.81

1.7

1.6

1238.1

1169.3

nmol/l

0.14

127

(3041096) Erythrocytes [Presence] in Urine by Automated

266

1.39

0.81

3.6

3.1

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.80

0.0

1.8

—

3.4

—

(1616796) Gas panel - Central venous blood

2.22

0.77

2.2

2.4

—

(3019225) pH of Specimen

1.61

0.75

3.7

3.8

—

(21494755) Public health laboratory ask at order entry panel

0.52

0.70

1.2

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

219

1.36

0.67

5.1

4.4

20.9

20.6

0.04

115

(3005322) IgE [Units/volume] in Serum or Plasma

1.68

0.63

1.1

1.3

536.5

184.1

u/ml

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.68

0.63

4.0

3.7

0.8

0.2

e6/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.60

0.0

1.6

—

(3049717) Cytology report of Urine Cyto stain

1.65

0.56

2.7

2.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.54

0.56

1.2

1.5

—

(40768797) Stomach Pathology biopsy report

126

1.41

0.55

1.4

1.3

—

(3008898) HLA-B27 [Presence]

1.57

0.54

1.5

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.46

0.54

1.2

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

191

1.32

0.52

1.4

1.3

3.1

2.5

g/l

0.65

116

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

148

1.34

0.47

7.3

3.1

3.6

2.4

e6/l

0.19

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

932

1.29

0.44

4.5

3.8

1.4

1.3

mmol/l

0.39

853

(46235355) HIV 1 and 2 tests - Meaningful Use set

141

1.33

0.43

1.2

1.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.59

0.43

1.6

1.4

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.38

0.42

1.3

1.6

1.5

1.2

g/l

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

3.1

—

15.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

3.0

—

4.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

3.0

—

106.3

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

102

977

1.31

0.41

5.2

4.9

2.7

2.8

mmol/l

0.21

899

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.49

0.41

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.49

0.41

1.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.49

0.41

1.0

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.40

0.0

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.40

0.0

1.8

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.45

0.40

1.0

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

112

0.69

0.39

3.3

7.3

—

(4010399)

1.29

0.37

1.2

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

210

1.24

0.36

1.3

1.2

4.6

2.5

u/ml

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.32

0.33

1.3

1.9

2.1

1.7

g/l

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.34

0.33

1.2

1.6

1.5

0.00

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.27

0.30

1.6

3.3

4.2

4.4

pmol/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

955

1.22

0.29

4.7

4.3

1.5

mmol/l

0.17

880

(3022621) pH of Urine by Test strip

1.25

0.28

2.5

2.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

873

1.18

0.27

21.1

13.8

40.4

39.9

0.30

662

(36660697) Celiac disease serology panel - Serum

1.25

0.26

1.2

1.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

161

1.21

0.26

3.5

3.0

0.6

0.7

ug/l

0.28

118

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.37

0.24

1.0

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

960

1.19

0.23

4.9

4.4

4.7

mmol/l

0.02

891

(40768443) Skin Pathology biopsy report

1.29

0.23

1.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.23

0.22

1.0

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

100

0.79

0.22

1.4

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.9

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

12.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.5

—

(4281824)

0.00

0.21

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3025941) Bacteria identified in Stool by Culture

1.24

0.20

1.0

1.3

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.6

—

34.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.21

0.20

2.5

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

162

0.85

0.17

1.6

1.5

—

(3000494) Fungus identified in Specimen by Culture

119

0.83

0.16

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.80

0.15

1.1

1.6

—

(4035726)

1.19

0.13

1.2

1.3

—

(3000492) Spirometry study

1.19

0.13

1.7

1.5

—

(3022145) Colonoscopy Study observation

115

1.15

0.11

1.5

1.3

—

(1761868) Lipid panel - Serum or Plasma

350

1.08

0.11

3.2

2.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.06

0.08

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.82

0.07

1.7

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

159

0.94

0.03

1.3

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

580

0.97

0.03

2.9

3.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

114

1.06

0.01

1.3

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

271

1.00

0.00

1.8

1.6

1.3

1.4

mmol/l

0.21

224

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

18.0

—

1298.5

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.6

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

2.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.4

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.7

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

4.2

—

0.7

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.8

—

2618.5

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

102.6

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.86

0.00

1.0

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.91

0.00

1.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.93

0.00

1.1

1.5

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_LSPLEX and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_LSPLEX	1.681 [1.22, 2.31]	0.001
Birth year	0.996 [0.99, 1.0]	0.403

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 391 females with G6_LSPLEX died.

Males

Parameter	HR [95% CI]	p-value
G6_LSPLEX	1.151 [0.85, 1.56]	0.365
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 342 males with G6_LSPLEX died.

Mortality risk

Mortality risk for people of age

years, who have G6_LSPLEX.

N-year risk	Females	Males
1	0.211%	0.198%
5	1.097%	1.208%
10	2.546%	2.93%
15	4.988%	5.664%
20	8.872%	9.948%

Relationships between endpoints

↥

Index endpoint: G6_LSPLEX – Lumbosacral plexus disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lumbosacral plexus disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints