peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
121 |
4. Check minimum number of eventsNone |
121 |
5. Include endpointsNone |
121 |
6. Filter based on genotype QC (FinnGen only) |
119 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates plexus lumbosacralis
Similar endpoints
↥List of similar endpoints to
Lumbosacral plexus disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 903 | 486 | 412 |
| Only index persons | 807 | 435 | 372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.12 | 55.89 | 56.21 |
| Only index persons | 54.07 | 54.21 | 53.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 119 | 71 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 54.99 | 52.75 | 58.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 121
- Matched controls
- 1210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.1
ICD-10 Finland
Lumbosacral plexus disorders
+∞
159.0
115
*
N03AX16
ATC
[U] pregabalin
11.3
41.8
73
143
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.7
27.8
46
80
M48.0
ICD-10 Finland
Spinal stenosis
8.7
25.5
40
65
M54.4
ICD-10 Finland
Lumbago with sciatica
7.4
25.2
50
105
N03AX12
ATC
[U] gabapentin; oral
6.8
23.2
50
113
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
9.5
21.4
29
39
N06AA09
ATC
amitriptyline; systemic
7.4
18.2
31
54
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.5
18.0
36
74
N02AX02
ATC
tramadol; systemic, rectal
5.3
17.7
82
343
G56.0
ICD-10 Finland
Carpal tunnel syndrome
22.1
17.4
25
14
ACC51
NOMESCO Finland
Release of median nerve
+∞
17.1
16
*
XA402
NOMESCO Finland
ENMG
39.4
16.3
20
6
M54.9
ICD-10 Finland
Dorsalgia, unspecified
6.4
15.8
31
62
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.1
14.1
24
41
N06AX21
ATC
duloxetine; oral
5.4
13.1
31
73
G54.0
ICD-10 Finland
Brachial plexus disorders
144.3
12.7
13
*
M54.1
ICD-10 Finland
Radiculopathy
17.1
12.3
19
13
N02AA05
ATC
oxycodone; systemic
4.1
11.1
39
125
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
11.7
11.0
20
20
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
120.0
10.6
11
*
M54.5
ICD-10 Finland
Low back pain
3.4
10.0
59
265
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
10.4
9.4
18
20
M79.6
ICD-10 Finland
Pain in limb
3.3
9.4
67
334
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.4
9.2
20
43
SPAT1153
SPAT
Removal of sutures
3.2
8.8
54
244
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.8
8.6
31
100
N06AX16
ATC
venlafaxine; oral
3.9
8.5
29
90
L03
ICPC
Low back symptom/complaint
3.2
8.1
45
191
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.9
8.0
19
44
AA1AD
NOMESCO Finland
CT of head and brain
3.1
7.7
44
189
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
7.3
57
288
L28
ICPC
Limited function/disability (L)
3.3
7.0
31
113
WX308
NOMESCO Finland
Sacral anesthesy
42.5
6.8
8
*
N02BF02
ATC
pregabalin; oral
6.0
6.8
18
34
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.9
6.8
44
201
N03AE01
ATC
clonazepam; systemic
6.9
6.7
16
26
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
13.3
6.7
11
9
A01
ICPC
Pain general/multiple sites
4.2
6.7
19
51
N03AX09
ATC
lamotrigine; oral
8.2
6.6
14
19
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
9.0
6.5
13
16
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
6.5
36
150
M01AH01
ATC
celecoxib; oral
3.1
6.3
31
120
3531A
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral plexus lesions
+∞
6.3
6
*
A46
ICD-10 Finland
Erysipelas
3.4
6.3
25
85
WX402
NOMESCO Finland
General anaesthesia
3.0
6.0
33
136
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
442
3.65
10.41
7.9
12.2
1.28
1.22
inr
0.18
23
122
81
455
3.36
9.18
5.1
5.5
1.22
1.22
mmol/l
0.17
67
392
76
424
3.13
8.48
3.0
2.4
—
—
—
0
0
30
100
3.66
7.87
3.9
6.4
0.86
1.18
mmol/l
0.19
22
76
87
555
3.02
7.10
8.3
9.2
3.88
4.00
e9/l
0.26
79
490
65
366
2.68
6.60
4.8
3.5
45.08
35.15
ng/l
0.20
50
245
71
426
2.61
6.22
5.5
4.8
1.22
1.22
mmol/l
0.14
65
388
44
210
2.72
6.13
2.9
2.0
—
—
—
0
0
99
727
2.99
5.37
3.5
3.8
15.01
14.75
pmol/l
0.50
90
650
35
158
2.71
5.36
1.5
1.2
2.04
7.10
u/ml
1.03
11
60
51
296
2.25
4.41
2.8
2.3
47.25
56.05
u/l
1.58
51
276
22
86
2.90
4.34
3.1
3.4
—
—
—
0
0
25
105
2.74
4.33
5.6
6.3
103.04
103.73
mmol/l
0.23
25
105
25
106
2.71
4.25
2.6
2.7
3.98
8.75
umol/l
1.71
20
93
34
168
2.42
4.24
1.5
1.2
12.50
30.74
iu/ml
—
8
55
60
387
2.09
3.85
2.5
2.3
80.56
77.06
nmol/l
0.37
54
344
61
404
2.03
3.57
3.6
4.2
33.72
35.78
g/l
1.90
56
383
59
393
1.98
3.34
3.3
2.6
122.24
113.95
ug/l
0.12
53
360
112
978
2.95
3.13
22.1
12.6
21.29
23.15
mg/l
0.27
101
762
26
135
2.18
2.83
2.3
1.7
29.58
29.46
s
0.05
26
130
14
54
2.80
2.82
3.7
3.1
1.97
1.38
mmol/l
—
8
42
55
374
1.86
2.81
2.3
1.9
92.95
93.68
pmol/l
0.05
37
194
105
891
2.35
2.66
4.6
4.5
1.97
1.92
mu/l
0.17
95
806
35
208
1.96
2.66
3.0
2.0
3.04
3.29
mg/l
0.30
29
179
7
15
4.88
2.64
1.1
1.0
—
—
—
0
0
51
346
1.82
2.57
5.6
3.1
—
—
—
0
0
19
90
2.32
2.55
2.3
2.1
0.20
0.22
g/l
0.78
19
84
65
480
1.77
2.43
5.8
4.6
0.00
0.00
estimate
-0.00
14
91
23
122
2.09
2.36
1.7
2.1
21.78
24.27
%
0.25
17
108
65
483
1.75
2.35
4.4
3.5
0.00
0.00
estimate
-0.00
13
82
64
474
1.74
2.34
4.5
3.5
0.00
0.00
estimate
-0.00
14
96
25
140
1.99
2.22
2.2
1.8
—
—
—
0
0
39
263
1.71
1.92
4.4
3.9
0.00
0.00
estimate
-0.00
13
85
29
180
1.80
1.89
3.9
3.4
2569.79
193.69
ng/l
0.45
19
136
18
95
2.05
1.87
1.8
1.6
—
—
—
0
0
18
98
1.98
1.73
1.8
1.7
—
—
—
0
0
38
264
1.64
1.65
2.9
3.1
1248.39
1310.78
ng/l
0.05
32
214
50
375
1.57
1.58
4.6
3.6
—
—
—
0
0
103
917
1.83
1.56
6.0
5.3
40.51
39.56
mmol/mol
0.50
88
854
113
1046
2.21
1.50
24.5
14.8
75.46
75.98
umol/l
0.07
113
1046
7
29
2.50
1.41
1.1
2.0
—
—
—
0
0
15
83
1.92
1.38
2.0
2.2
354.07
354.21
nmol/l
0.00
15
75
5
17
3.02
1.37
3.4
1.2
—
—
—
0
0
6
24
2.58
1.32
1.2
1.1
0.00
0.00
g/l
—
6
24
6
25
2.47
1.26
1.2
1.3
—
—
—
0
0
24
159
1.64
1.24
6.0
2.6
0.78
1.15
e6/l
0.49
18
95
11
57
2.02
1.21
2.0
1.5
—
—
—
0
0
8
40
2.07
1.14
1.3
1.1
—
—
—
0
0
115
1085
2.21
1.12
30.1
18.9
39.51
40.14
%
0.77
109
1029
9
45
2.08
1.07
2.2
1.2
—
—
—
0
0
7
34
2.12
1.04
2.6
2.0
—
—
—
0
0
9
48
1.94
1.03
3.2
2.5
1.32
1.41
%
—
9
48
101
923
1.57
1.03
17.7
12.2
81.95
80.22
ml/min/173m2
0.38
94
766
103
950
1.57
0.95
4.8
4.6
5.84
5.92
mmol/l
0.34
94
876
24
171
1.50
0.92
1.7
1.6
1190.61
1170.83
nmol/l
0.04
18
131
36
283
1.39
0.83
4.3
3.4
14.35
7.05
mg/mmol
0.35
20
171
6
34
1.80
0.77
3.0
2.3
—
—
—
0
0
7
38
1.89
0.75
3.1
2.2
—
—
—
0
0
29
226
1.37
0.70
5.1
4.5
21.51
20.49
%
0.14
14
119
20
149
1.41
0.63
7.0
3.0
3.59
2.43
e6/l
0.19
14
86
8
50
1.64
0.63
5.0
2.6
31.54
41.38
u/l
—
8
41
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
26
213
1.28
0.46
1.3
1.2
4.23
2.54
u/ml
0.19
11
56
5
32
1.59
0.43
1.6
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
3.1
—
15.85
—
0
15
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
5
35
1.45
0.40
1.0
1.3
—
—
—
0
0
5
35
1.45
0.40
1.0
1.3
—
—
—
0
0
8
113
0.69
0.39
3.3
7.3
—
—
—
0
0
5
36
1.41
0.38
1.0
1.6
—
—
—
0
0
99
947
1.25
0.37
4.5
3.8
1.36
1.29
mmol/l
0.40
92
867
103
993
1.25
0.32
5.2
4.9
2.72
2.80
mmol/l
0.35
93
917
20
166
1.25
0.32
3.5
3.0
0.66
0.73
ug/l
0.22
15
122
12
97
1.26
0.24
1.2
1.6
1.51
1.51
%
0.00
12
84
5
40
1.26
0.22
1.0
1.6
—
—
—
0
0
100
971
1.17
0.22
4.7
4.3
1.50
1.49
mmol/l
0.09
92
897
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
1.33
—
0
7
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
14
163
0.84
0.18
1.6
1.5
—
—
—
0
0
7
59
1.20
0.18
1.6
3.3
4.19
4.37
pmol/l
—
7
53
100
976
1.14
0.17
4.9
4.4
4.69
4.71
mmol/l
0.09
92
907
5
60
0.83
0.08
1.0
1.3
—
—
—
0
0
8
75
1.07
0.07
1.1
1.5
—
—
—
0
0
15
160
0.93
0.04
1.3
1.4
—
—
—
0
0
27
276
0.97
0.00
1.8
1.6
1.32
1.36
mmol/l
0.12
22
227
58
586
0.98
0.00
2.8
2.9
—
—
—
0
0
8
86
0.93
0.00
1.1
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
102.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1683.40
—
0
5
7
69
1.02
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.681 [1.22, 2.31] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 391 females with G6_LSPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.151 [0.85, 1.56] | 0.365 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 342 males with G6_LSPLEX died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.198% |
| 5 | 1.097% | 1.208% |
| 10 | 2.546% | 2.93% |
| 15 | 4.988% | 5.664% |
| 20 | 8.872% | 9.948% |
Relationships between endpoints
↥Index endpoint: G6_LSPLEX – Lumbosacral plexus disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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