peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
119 |
4. Check minimum number of eventsNone |
119 |
5. Include endpointsNone |
119 |
6. Filter based on genotype QC (FinnGen only) |
119 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates plexus lumbosacralis
Similar endpoints
↥List of similar endpoints to
Lumbosacral plexus disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 903 | 486 | 412 |
| Only index persons | 807 | 435 | 372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.12 | 55.89 | 56.21 |
| Only index persons | 54.07 | 54.21 | 53.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 119 | 71 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 54.91 | 52.61 | 58.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 103
- Matched controls
- 1030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.1
ICD-10 Finland
Lumbosacral plexus disorders
+∞
133.3
97
*
N03AX16
ATC
pregabalin; oral
9.4
23.4
61
137
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
9.6
17.6
39
61
N03AX12
ATC
gabapentin; oral
8.2
16.4
41
77
N02AX02
ATC
tramadol; systemic, rectal
5.9
15.9
72
290
M48.0
ICD-10 Finland
Spinal stenosis
9.2
14.5
32
48
M54.4
ICD-10 Finland
Lumbago with sciatica
7.1
14.3
39
81
N06AA09
ATC
amitriptyline; systemic
9.2
13.3
29
42
G56.0
ICD-10 Finland
Carpal tunnel syndrome
15.2
12.3
20
16
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
9.6
12.1
25
33
ACC51
NOMESCO Finland
Release of median nerve
73.5
11.9
13
*
XA402
NOMESCO Finland
ENMG
20.7
11.1
16
9
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
10.6
10
*
M54.5
ICD-10 Finland
Low back pain
4.1
9.9
50
194
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.3
9.7
27
55
M54.9
ICD-10 Finland
Dorsalgia, unspecified
6.4
9.3
25
49
M54.1
ICD-10 Finland
Radiculopathy
16.0
9.0
14
10
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
9.9
8.7
17
20
N06AX21
ATC
duloxetine; oral
6.1
8.6
24
49
N02AA05
ATC
oxycodone; systemic
4.9
8.6
30
80
G54.0
ICD-10 Finland
Brachial plexus disorders
97.7
8.5
9
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
7.0
7.8
19
32
M79.6
ICD-10 Finland
Pain in limb
3.4
7.8
51
231
AA1AD
NOMESCO Finland
CT of head and brain
3.7
7.6
39
146
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.2
7.4
60
313
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.5
6.9
20
43
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.9
6.6
28
89
WX308
NOMESCO Finland
Sacral anesthesy
74.3
6.5
7
*
R51.80
ICD-10 Finland
Headache
4.4
6.3
23
63
3531A
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral plexus lesions
+∞
6.3
6
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.681 [1.22, 2.31] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 391 females with G6_LSPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.151 [0.85, 1.56] | 0.365 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 342 males with G6_LSPLEX died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.198% |
| 5 | 1.097% | 1.208% |
| 10 | 2.546% | 2.93% |
| 15 | 4.988% | 5.664% |
| 20 | 8.872% | 9.948% |
Relationships between endpoints
↥Index endpoint: G6_LSPLEX – Lumbosacral plexus disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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