This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Operations 1 for CAVS
I9_CAVS_OPERATIONS1
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
93 |
4. Check minimum number of eventsNone |
93 |
5. Include endpointsNone |
93 |
6. Filter based on genotype QC (FinnGen only) |
93 |
Control definitions (FinnGen only)
- Control exclude
- I9_CAVS
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Operations 1 for CAVS
based on the number of shared cases.
Similar with more cases:
- Valvular operations
- Calcific aortic valvular stenosis, operated
- Calcific aortic valvular stenosis
- Valvular heart disease excluding rheumatic fever
- Other heart diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 93 | 49 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 61.63 | 61.80 | 61.45 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 86
- Matched controls
- 859
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2121.2
76.8
63
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
66.7
45.6
52
19
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
151.6
36.1
36
*
FMB10
NOMESCO Finland
Transannular expansion of aortic ostium
+∞
36.0
32
*
B01AA03
ATC
warfarin; systemic
22.1
35.0
65
105
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
36.5
35.0
46
26
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
+∞
31.1
28
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
29.9
27
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
+∞
29.9
27
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
16.1
28.5
56
89
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
15.0
27.7
58
104
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
14.6
25.2
49
71
WX872
NOMESCO Finland
Intensive care
28.7
24.8
34
19
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.6
23.2
55
114
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
21.8
20
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
31.3
19.1
25
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
9.4
19.0
69
259
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
12.9
16.2
30
34
C07AB07
ATC
bisoprolol; oral
7.4
16.2
64
243
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
16.1
15
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
15.0
14
*
FMB00
NOMESCO Finland
Supravalvular aortic expansion using patch
+∞
13.9
13
*
FMA32
NOMESCO Finland
Percutaneous transluminal expansion of aortic valve
+∞
13.9
13
*
C03CA01
ATC
furosemide; systemic
6.0
13.6
52
175
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
11.7
11
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
12.2
11.6
21
22
B01AB05
ATC
enoxaparin; parenteral
5.2
10.6
40
123
AP6
HP
Valveoplasty of the aortic valve
+∞
10.6
10
*
FMB96
NOMESCO Finland
Other expansion of aortic ostium
+∞
10.6
10
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
45.8
10.3
12
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
30.2
10.1
13
5
WX408
NOMESCO Finland
General anesthesy, balanced
4.6
9.8
44
160
AN1
HP
Coronary angiography
6.7
9.7
26
52
K83
ICPC
Heart valve disease NOS
34.4
9.7
12
*
AB2
HP
AVR bio, stent
+∞
9.5
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
6.1
9.3
27
60
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.6
8.9
21
35
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
99.4
8.6
9
*
XF402
NOMESCO Finland
ECG with work load test
6.7
8.5
22
42
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
37.2
8.3
10
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
37.2
8.3
10
*
XF404
NOMESCO Finland
Ambulatory ECG
6.8
8.2
21
39
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
7.9
32
101
201
Kela drug reimbursment
Chronic cardiac insufficiency
8.7
7.6
16
22
I50.9
ICD-10 Finland
Heart failure, unspecified
4.6
7.5
28
81
AA1AD
NOMESCO Finland
CT of head and brain
4.2
7.1
30
98
XF600
NOMESCO Finland
Bloodpressure measurement
5.9
6.9
19
39
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
43.6
6.9
8
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
11.4
6.8
12
12
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
7.0
6.7
16
27
WX402
NOMESCO Finland
General anaesthesia
4.1
6.6
28
91
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
6.5
6.4
16
29
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
29.0
6.3
8
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
6.3
6
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
6.3
6
*
FMD22
NOMESCO Finland
Percutaneous transluminal replacement of aortic valve using biological prosthesis
+∞
6.3
6
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
87
7.00
18.45
39.7
20.0
2.4
1.2
inr
—
10
12
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
23
11.50
18.04
36.7
6.0
0.3
0.4
u/ml
0.80
16
14
21
44
5.87
10.11
34.2
6.8
77.2
88.8
%
1.48
21
44
46
188
3.86
9.45
3.3
2.8
—
—
—
0
0
13
18
8.23
9.09
1.7
1.8
—
—
—
0
0
29
89
4.28
8.84
6.9
5.3
284.3
311.5
u/l
0.15
29
84
17
33
6.08
8.79
5.8
7.5
157.1
188.0
%
0.87
17
33
28
88
4.12
8.22
16.9
13.8
7.0
7.5
mmol/l
0.17
28
81
59
337
3.05
6.30
4.9
4.5
—
—
—
0
0
51
284
2.76
5.47
4.1
3.9
287.8
42.4
ng/l
2.00
35
203
60
382
2.61
4.65
6.7
8.7
16.6
14.2
umol/l
0.29
55
361
23
92
2.99
4.47
10.9
15.8
25.0
24.4
mmol/l
0.40
23
92
6
7
9.05
3.31
5.3
9.3
84.2
87.0
%
—
6
7
28
143
2.37
3.31
10.5
3.3
2.4
1.8
mg/l
0.17
20
119
12
40
3.30
3.10
16.2
12.7
24.0
24.8
mmol/l
0.44
12
35
22
104
2.46
3.05
6.5
10.1
106.6
104.2
mmol/l
1.30
22
98
19
90
2.40
2.61
11.9
10.7
5.0
5.0
kpa
0.29
19
81
9
26
3.72
2.56
1.8
2.1
—
—
—
0
0
22
113
2.24
2.52
1.7
2.0
—
—
—
0
0
9
27
3.58
2.46
1.9
2.4
—
—
—
0
0
6
13
4.85
2.31
1.3
1.5
—
—
—
0
0
6
15
4.20
2.07
1.0
1.7
—
—
—
0
0
23
132
1.99
1.97
22.0
10.6
1.2
1.2
mmol/l
0.33
23
122
36
243
1.79
1.88
4.0
4.0
49.3
32.7
u/l
0.44
36
237
10
41
2.61
1.82
1.2
1.6
—
—
—
0
0
14
69
2.21
1.75
13.9
12.8
10.0
9.5
kpa
0.59
14
63
7
25
2.94
1.68
1.6
2.1
—
—
—
0
0
7
26
2.83
1.61
1.6
2.2
—
—
—
0
0
21
125
1.88
1.61
5.4
10.3
1.9
1.6
mmol/l
0.20
16
92
28
187
1.71
1.47
2.6
3.0
2.7
3.1
mg/l
0.46
22
162
6
23
2.72
1.39
1.8
2.7
—
—
—
0
0
54
436
1.57
1.29
10.3
13.7
4.4
4.0
e9/l
0.77
49
376
15
86
1.89
1.28
15.7
12.4
1.0
1.4
mmol/l
2.04
15
80
15
90
1.79
1.12
1.9
2.5
426.6
320.3
nmol/l
1.40
15
84
46
367
1.50
1.11
13.4
10.5
1.2
1.2
mmol/l
1.41
39
312
5
21
2.46
1.10
1.0
2.2
—
—
—
0
0
9
49
1.92
1.02
3.9
11.6
1.4
1.5
%
—
9
49
13
81
1.70
0.86
1.6
1.8
—
—
—
0
0
13
81
1.70
0.86
1.5
1.7
—
—
—
0
0
10
63
1.66
0.65
4.7
4.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.6
—
—
—
0
0
10
145
0.65
0.56
3.4
3.9
1.1
1.0
e6/l
—
5
98
61
662
0.77
0.51
5.0
4.5
5.7
6.0
mmol/l
1.94
56
596
21
257
0.76
0.45
5.1
4.7
—
—
—
0
0
8
55
1.50
0.44
2.5
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
7.9
—
0
10
0
18
0.00
0.40
0.0
1.0
—
19.0
—
0
18
19
232
0.77
0.40
4.2
4.5
0.1
0.3
e6/l
1.97
14
181
25
216
1.22
0.30
3.0
3.0
60.0
62.4
u/l
0.09
25
203
31
346
0.84
0.27
6.6
6.0
0.0
0.0
estimate
—
7
63
64
605
1.19
0.27
19.2
15.1
78.7
79.5
ml/min/173m2
0.09
58
485
6
81
0.72
0.25
2.2
1.4
—
—
—
0
0
62
652
0.85
0.25
5.8
4.5
1.3
1.5
mmol/l
3.20
57
587
11
135
0.79
0.24
3.2
4.1
1.0
2.0
e6/l
—
5
90
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
6
50
1.21
0.20
9.5
3.7
52.3
50.4
%
—
6
50
77
746
1.19
0.19
26.1
15.9
34.1
22.0
mg/l
2.45
72
562
18
157
1.18
0.19
1.6
1.8
—
—
—
0
0
51
482
1.13
0.18
3.1
3.3
—
—
—
0
0
8
99
0.79
0.14
16.8
8.1
—
—
—
0
0
32
340
0.91
0.12
3.4
4.5
0.0
0.0
estimate
—
7
60
33
348
0.92
0.10
4.3
4.4
0.0
0.0
estimate
—
7
57
16
174
0.90
0.08
1.1
1.5
1.4
1.2
u/ml
—
5
37
15
162
0.91
0.06
1.3
1.5
20.5
21.0
nmol/l
0.05
15
138
19
179
1.08
0.05
3.8
4.9
0.0
0.0
estimate
—
5
61
65
658
0.96
0.02
5.7
4.5
4.3
4.5
mmol/l
1.30
60
600
28
273
1.04
0.01
1.6
2.0
105.5
91.3
pmol/l
0.78
16
128
63
637
0.97
0.01
5.5
4.1
1.4
1.3
mmol/l
0.92
58
569
27
276
0.97
0.00
3.6
4.5
—
—
—
0
0
17
168
1.01
0.00
4.9
4.6
31.0
22.6
%
—
9
85
66
661
0.99
0.00
4.4
4.5
2.0
2.0
mu/l
0.15
61
584
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
7
0.00
0.00
0.0
6.9
—
225.1
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
8
86
0.92
0.00
9.9
4.7
31.9
32.7
%
—
8
45
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
7.1
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: I9_CAVS_OPERATIONS1 – Operations 1 for CAVS
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).