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Operations 1 for CAVS

Endpoint Browser

I9_CAVS_OPERATIONS1

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Operations: NOMESCO codes — ^FMA|^FMB

1 out of 7 registries used, show all original rules.

99

4. Check minimum number of events

None

99

5. Include endpoints

None

99

6. Filter based on genotype QC (FinnGen only)

97

Control definitions (FinnGen only)

Control exclude
I9_CAVS

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 97 51 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 61.42 62.20 60.57

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
99
Matched controls
990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
80.8
103.5
63
21
I35.0
ICD-10 Finland
Aortic (valve) stenosis
1462.7
91.0
75
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
40.0
74.7
55
30
B01AA03
ATC
warfarin; systemic
35.0
71.2
77
90
WX872
NOMESCO Finland
Intensive care
51.4
66.9
42
14
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
19.5
51.7
68
100
FMB10
NOMESCO Finland
Transannular expansion of aortic ostium
+∞
46.6
41
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
373.3
46.2
43
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
15.7
43.0
70
132
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
+∞
39.2
35
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
12.3
36.7
59
106
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
266.4
36.4
35
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.3
33.7
64
138
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
424.2
31.7
30
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
14.1
26.6
28
27
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.7
25.5
34
46
GD1AA
NOMESCO Finland
Thorax X-ray examination
11.2
23.7
83
313
Q23.11
ICD-10 Finland
Bicuspid aortic valve
139.7
21.5
22
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
23.1
21.4
31
19
C07AB07
ATC
bisoprolol; oral
8.1
19.1
79
325
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
16.1
15
*
C03CA01
ATC
furosemide; systemic
5.4
15.5
60
221
AN1
HP
Coronary angiography
6.7
14.9
29
58
XF402
NOMESCO Finland
ECG with work load test
7.6
14.6
24
40
ZXE20
NOMESCO Finland
More than three and less than five hours
5.9
14.6
34
81
TPH07
NOMESCO Finland
Cathetrisation of artery
6.3
14.4
30
64
FMA32
NOMESCO Finland
Percutaneous transluminal expansion of aortic valve
+∞
13.9
13
*
FMB00
NOMESCO Finland
Supravalvular aortic expansion using patch
+∞
13.9
13
*
K83
ICPC
Heart valve disease NOS
161.2
13.8
14
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
161.2
13.8
14
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.4
13.2
22
37
WX408
NOMESCO Finland
General anesthesy, balanced
4.6
12.9
50
179
AB2
HP
AVR bio, stent
+∞
12.8
12
*
FMB96
NOMESCO Finland
Other expansion of aortic ostium
+∞
12.8
12
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.6
12.7
62
264
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
53.7
12.2
14
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.5
12.2
23
44
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
+∞
11.7
11
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
6.7
11.2
20
36
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
24.9
11.1
15
7
ZXD05
NOMESCO Finland
Urgent procedure
4.1
10.9
48
185
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
122.4
10.6
11
*
XF404
NOMESCO Finland
Ambulatory ECG
5.9
10.6
22
46
AP6
HP
Valveoplasty of the aortic valve
+∞
10.6
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.5
10.5
34
104
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
9.9
10.5
21
26
B01AB05
ATC
enoxaparin; parenteral
3.9
10.2
47
185
Q25.1
ICD-10 Finland
Coarctation of aorta
61.2
9.9
11
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
15.8
9.5
15
11
201
Kela drug reimbursment
Chronic cardiac insufficiency
9.7
9.1
18
22
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
8.4
8
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
9.1
8.3
17
22
WX892
NOMESCO Finland
Monitored bed care
5.4
8.3
18
39
ZXE00
NOMESCO Finland
One hour or less
3.4
8.2
54
260
K99
ICPC
Cardiovascular disease other
49.0
7.8
9
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
27.5
7.7
10
*
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
12.3
7.6
13
12
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
86.3
7.5
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.7
7.4
30
105
FMD22
NOMESCO Finland
Percutaneous transluminal replacement of aortic valve using biological prosthesis
+∞
7.4
7
*
G45.3
ICD-10 Finland
Amaurosis fugax
22.0
7.3
10
5
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.4
7.0
32
121
R4110
NOMESCO Finland
Physiotherapy
3.1
7.0
43
195
C03DA01
ATC
spironolactone; oral
4.0
6.9
23
70
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
24.5
6.8
9
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
12.2
6.5
11
10
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
19.6
6.4
9
5
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
28.7
6.3
8
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
+∞
6.3
6
*
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
+∞
6.3
6
*
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
6.3
6
*
WX402
NOMESCO Finland
General anaesthesia
3.1
6.3
34
142
FM2CE, ,
NOMESCO Finland
9.6
6.3
12
14
C10AA05
ATC
atorvastatin; oral
2.9
6.2
50
260
WX002
NOMESCO Finland
Sedation and analgesia
3.4
6.2
26
93
AA1AD
NOMESCO Finland
CT of head and brain
3.0
6.1
35
151
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.9
6.0
12
15

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
340
9.92
20.79
51.8
11.9
2.18
1.20
inr
10.22
33
88
56
256
3.73
9.60
3.4
3.0
—
—
—
0
0
29
93
4.00
8.23
16.4
13.5
6.86
7.49
mmol/l
0.24
29
86
65
411
2.69
5.19
6.6
9.0
18.32
15.62
umol/l
0.31
60
387
26
103
3.07
5.15
13.6
17.0
24.88
24.40
mmol/l
0.42
26
103
15
34
5.01
5.00
22.0
21.0
—
—
—
0
0
27
114
2.88
4.76
16.0
14.3
—
—
—
0
0
51
301
2.43
4.52
4.1
3.8
287.78
40.83
ng/l
2.02
35
216
25
109
2.73
4.11
9.5
10.5
107.12
104.32
mmol/l
1.77
25
109
20
78
2.96
4.02
10.3
13.4
—
—
—
0
0
39
214
2.36
3.96
5.4
4.4
—
—
—
0
0
27
128
2.53
3.74
2.5
2.0
—
—
—
0
0
30
161
2.24
3.11
9.9
3.2
2.22
1.69
mg/l
0.17
22
134
21
101
2.37
2.78
11.4
11.9
5.04
4.96
kpa
0.35
21
95
5
6
8.69
2.78
5.6
3.8
—
—
—
0
0
8
19
4.48
2.74
4.3
25.4
67.13
68.82
%
—
8
19
57
404
1.97
2.73
7.4
9.2
0.04
0.04
e9/l
0.80
48
340
58
419
1.93
2.57
8.6
9.6
0.22
0.20
e9/l
0.29
50
359
7
17
4.34
2.40
9.1
4.4
8.69
8.68
kpa
—
7
17
7
17
4.34
2.40
9.1
4.4
5.40
4.90
kpa
—
7
17
56
406
1.87
2.40
7.5
9.1
0.62
0.59
e9/l
0.31
48
342
34
211
1.93
2.34
1.4
1.5
—
—
—
0
0
7
19
3.88
2.19
4.4
3.6
—
—
—
0
0
56
418
1.78
2.08
7.7
9.1
1.62
1.98
e9/l
3.64
48
362
33
210
1.86
2.08
5.8
3.9
—
—
—
0
0
24
137
1.99
2.07
21.2
10.8
1.23
1.19
mmol/l
0.30
24
127
8
28
3.02
1.91
5.8
18.1
—
—
—
0
0
7
23
3.19
1.83
10.3
3.9
7.41
7.41
ph
—
7
17
19
108
1.94
1.65
2.8
1.9
—
—
—
0
0
5
14
3.70
1.63
5.2
33.3
10.92
11.44
%
—
5
14
61
492
1.62
1.51
6.1
3.8
—
—
—
0
0
12
59
2.18
1.51
1.2
1.4
93.75
623.53
u/ml
0.70
12
53
50
387
1.59
1.45
8.6
9.6
—
—
—
0
0
29
197
1.67
1.41
2.5
3.0
2.71
3.11
mg/l
0.44
23
167
58
470
1.57
1.35
10.1
13.4
4.29
3.96
e9/l
0.64
52
404
10
49
2.16
1.27
4.0
12.4
0.84
0.68
%
—
10
49
16
94
1.84
1.26
1.8
2.5
411.56
327.59
nmol/l
1.02
16
87
15
87
1.85
1.23
1.6
1.1
—
—
—
0
0
11
57
2.05
1.22
5.7
10.4
122.91
122.35
g/l
0.03
11
57
49
390
1.51
1.19
14.3
10.8
1.18
1.22
mmol/l
1.80
42
328
9
46
2.05
1.07
8.4
4.2
—
—
—
0
0
10
53
1.99
1.05
4.0
11.7
1.37
1.44
%
—
10
53
0
28
0.00
0.99
0.0
1.6
—
16.90
—
0
20
7
36
2.01
0.99
8.9
5.8
—
—
—
0
0
11
62
1.87
0.99
1.5
1.5
—
—
—
0
0
8
42
1.98
0.91
5.3
4.0
25.89
24.65
mmol/l
—
8
42
11
64
1.81
0.90
1.6
3.3
63.12
65.62
g/l
0.54
11
58
14
91
1.63
0.80
1.5
1.5
—
—
—
0
0
13
83
1.65
0.79
3.5
2.7
9.52
8.51
g/l
0.46
13
76
5
24
2.14
0.75
1.2
1.6
—
—
—
0
0
9
56
1.67
0.75
1.3
1.4
—
—
—
0
0
24
300
0.74
0.60
2.1
2.0
—
—
—
0
0
8
54
1.52
0.59
16.4
5.1
1.20
1.22
mmol/l
—
8
48
13
93
1.46
0.51
1.8
1.7
—
—
—
0
0
43
375
1.26
0.48
15.7
12.7
0.00
0.00
e9/l
-0.00
35
303
25
205
1.29
0.45
3.1
3.3
44.00
65.97
mg/l
0.26
17
138
0
16
0.00
0.41
0.0
4.1
—
65.88
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
85
810
1.35
0.41
24.4
13.8
—
—
—
0
0
8
61
1.34
0.40
4.3
7.0
48.88
65.34
ng/l
—
8
56
16
201
0.76
0.40
5.8
4.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
278.17
—
0
12
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
21
248
0.81
0.33
3.9
4.4
0.07
0.31
e6/l
1.88
14
192
7
98
0.69
0.32
1.1
1.2
—
—
—
0
0
10
75
1.37
0.31
2.3
1.8
1.00
0.96
g/l
—
10
69
83
797
1.26
0.30
25.2
15.7
34.71
21.77
mg/l
2.97
78
599
33
369
0.84
0.30
6.7
6.0
0.00
0.00
estimate
—
7
67
66
697
0.84
0.29
4.9
4.5
5.80
5.99
mmol/l
0.91
61
626
5
71
0.69
0.27
1.2
1.2
—
—
—
0
0
5
70
0.70
0.27
1.6
1.7
—
—
—
0
0
22
191
1.20
0.24
1.8
1.6
1.83
1.92
g/l
0.10
16
114
24
212
1.17
0.22
4.3
4.0
8.39
7.07
mg/mmol
0.07
15
141
8
104
0.75
0.22
1.5
3.7
49.38
140.18
ug/g
—
8
79
53
498
1.14
0.21
3.5
5.0
—
5050.73
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
24
213
1.17
0.21
9.3
4.8
7.40
7.41
ph
—
7
41
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
6
52
1.16
0.19
8.5
2.8
—
—
—
0
0
7
59
1.20
0.18
1.3
1.5
—
—
—
0
0
7
61
1.16
0.18
5.1
3.9
—
—
—
0
0
31
284
1.13
0.18
1.6
2.0
101.32
90.66
pmol/l
0.56
18
135
9
79
1.15
0.16
1.9
1.6
—
—
—
0
0
12
138
0.85
0.14
1.8
1.8
—
—
—
0
0
67
692
0.90
0.14
5.6
4.5
1.32
1.46
mmol/l
3.06
62
623
35
371
0.91
0.12
4.3
4.3
0.00
0.00
estimate
—
7
61
25
231
1.11
0.12
3.0
2.9
60.04
80.75
u/l
0.46
25
216
24
222
1.11
0.11
2.5
3.5
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
35
364
0.94
0.06
4.3
4.4
0.00
0.00
estimate
—
9
66
16
169
0.94
0.03
1.3
1.6
19.96
21.21
nmol/l
0.15
16
142
71
702
1.04
0.02
4.2
4.6
1.95
2.05
mu/l
0.24
66
624
52
528
0.97
0.02
4.0
4.8
—
—
—
0
0
30
294
1.03
0.00
4.0
5.4
12.02
82.71
e6/l
1.99
19
219
18
182
0.99
0.00
2.8
4.2
—
—
—
0
0
26
262
0.99
0.00
3.6
4.8
16.98
29.29
e6/l
0.99
18
205
11
107
1.03
0.00
1.8
1.5
—
—
—
0
0
70
699
1.00
0.00
5.6
4.6
4.32
4.56
mmol/l
1.04
65
637
19
187
1.02
0.00
1.1
1.5
1.44
1.15
u/ml
—
5
42
24
237
1.02
0.00
3.0
3.1
—
—
—
0
0
24
237
1.02
0.00
5.9
9.3
—
—
—
0
0
68
677
1.01
0.00
5.3
4.1
1.43
1.29
mmol/l
1.04
63
605
13
125
1.05
0.00
1.8
1.7
—
—
—
0
0
19
189
1.01
0.00
3.8
4.9
0.00
0.00
estimate
—
5
64
24
239
1.01
0.00
3.7
4.4
—
—
—
0
0
87
874
0.96
0.00
45.8
24.4
38.26
39.70
%
1.24
82
828
0
7
0.00
0.00
0.0
22.3
—
251.71
—
0
7
7
74
0.94
0.00
2.1
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
1.08
—
0
7
0
7
0.00
0.00
0.0
2.0
—
3.69
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
13.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.34
—
0
5
0
9
0.00
-0.00
0.0
2.3
—
1.43
—
0
9
6
69
0.86
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.52
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.62
—
0
6
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
19.4
—
7.24
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
56
0.89
-0.00
1.8
2.2
15.88
13.06
nmol/l
—
5
51
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
151.00
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
42.4
—
0.64
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
15.02
—
0
6

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: I9_CAVS_OPERATIONS1 – Operations 1 for CAVS

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).