portal hypertension: Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpointsNone |
102 |
6. Filter based on genotype QC (FinnGen only) |
102 |
Control definitions (FinnGen only)
- Control exclude
- CIRRHOSIS_BROAD
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K76
- Name in latin
- Hypertensio venae portae
Similar endpoints
↥List of similar endpoints to
Hypertension, portal
based on the number of shared cases.
Similar with more cases:
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Other diseases of liver
- Diseases of liver
- Gastrointestinal diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 745 | 296 | 439 |
| Only index persons | 603 | 241 | 362 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.88 | 59.75 | 58.18 |
| Only index persons | 58.65 | 58.48 | 58.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 102 | 45 | 57 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 57.91 | 57.97 | 57.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 91
- Matched controls
- 909
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K76.6
ICD-10 Finland
Portal hypertension
+∞
128.1
90
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
48.3
42
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
32.4
41.8
79
153
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
40.7
36
*
R18
ICD-10 Finland
Ascites
462.3
33.1
31
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
18.0
31.4
57
77
C03DA01
ATC
spironolactone; oral
19.5
29.1
48
49
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
+∞
28.7
26
*
C03CA01
ATC
furosemide; systemic
13.3
27.4
63
131
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
113.1
24.1
25
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
22.9
21
*
C07AA05
ATC
propranolol; systemic
10.3
20.6
48
89
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
+∞
20.6
19
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.6
18.6
34
38
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
47.5
18.6
22
6
D64.9
ICD-10 Finland
Anaemia, unspecified
11.9
15.7
30
36
A06AD11
ATC
lactulose; oral
8.6
15.1
36
64
K70.4
ICD-10 Finland
Alcoholic hepatic failure
+∞
15.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.2
14.3
67
283
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
163.4
13.9
14
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
27.6
13.5
18
8
K70.1
ICD-10 Finland
Alcoholic hepatitis
+∞
12.8
12
*
Z94.4
ICD-10 Finland
Liver transplant status
+∞
12.8
12
*
UJF32
NOMESCO Finland
Coloscopy
5.5
12.5
48
154
ZX120
NOMESCO Finland
Intravenous
9.1
12.0
26
38
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.6
11.9
34
75
K92.1
ICD-10 Finland
Melaena
15.6
11.8
19
15
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.4
11.4
41
120
103
Kela drug reimbursment
Diabetes, insulin-treated
5.2
11.3
43
134
127
Kela drug reimbursment
Transplant complication
50.0
11.2
13
*
WW500
NOMESCO Finland
Blood transfusion
15.7
11.2
18
14
I81
ICD-10 Finland
Portal vein thrombosis
68.3
10.9
12
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.2
10.9
23
32
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
123.7
10.7
11
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
10.6
10
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.0
10.4
40
124
TPH04
NOMESCO Finland
Cathetrisation of vein
5.0
10.3
39
118
A10AE04
ATC
insulin glargine; parenteral
7.2
10.2
26
48
K92.0
ICD-10 Finland
Haematemesis
23.3
10.2
14
7
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.4
10.0
28
59
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
61.8
9.9
11
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
7.7
9.7
23
38
Z2446
NOMESCO Finland
Social worker
8.8
9.7
21
30
K83.0
ICD-10 Finland
Cholangitis
34.1
9.7
12
*
N02AX02
ATC
tramadol; systemic, rectal
4.2
9.6
58
269
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
9.5
9
*
K76.9
ICD-10 Finland
Liver disease, unspecified
41.2
9.2
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.3
9.2
19
25
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
9.2
44
163
L04AA06
ATC
mycophenolic acid; systemic
27.3
9.2
12
5
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
7.0
9.1
23
42
J01MA02
ATC
ciprofloxacin; systemic
3.9
8.9
54
247
L04AD01
ATC
ciclosporin; systemic
30.9
8.7
11
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
98.8
8.6
9
*
I86.4
ICD-10 Finland
Gastric varices
+∞
8.5
8
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
8.5
8
*
A10BA02
ATC
metformin; oral
4.1
8.3
38
134
T90
ICPC
Diabetes non-insulin dependent
4.3
8.2
35
116
R4110
NOMESCO Finland
Physiotherapy
4.0
8.2
40
148
UJD02
NOMESCO Finland
Gastroscopy
8.8
8.1
17
23
Z51.5
ICD-10 Finland
Palliative care
11.6
7.9
14
14
J01MA12
ATC
levofloxacin; systemic
4.4
7.8
31
95
C07AG02
ATC
carvedilol; oral
8.1
7.7
17
25
A10BB12
ATC
glimepiride; oral
8.1
7.7
17
25
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.9
7.5
26
69
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
5.0
7.5
25
64
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.6
7.4
19
35
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
17.6
7.4
11
7
A02BC02
ATC
pantoprazole; systemic
3.9
7.4
73
463
JJ5AT
NOMESCO Finland
NA
+∞
7.4
7
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.7
7.0
20
43
JN3AD
NOMESCO Finland
Abdominal CT examination
5.7
7.0
20
43
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
7.9
6.9
15
22
N02AA05
ATC
oxycodone; systemic
4.7
6.6
23
61
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
9.3
6.6
13
16
JN4BD
NOMESCO Finland
Extensive body CT
5.0
6.6
21
51
D97
ICPC
Liver disease NOS
74.9
6.5
7
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
74.9
6.5
7
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.3
6.5
15
24
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.7
6.4
13
17
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
6.3
6
*
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
+∞
6.3
6
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
6.3
43
199
TK800
NOMESCO Finland
Hemodialysis
11.2
6.2
11
11
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
6.2
30
108
ZXD05
NOMESCO Finland
Urgent procedure
3.2
6.1
40
179
A02BC05
ATC
esomeprazole; systemic
3.0
6.0
46
229
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSPOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 11.525 [6.2, 21.42] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.111 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 189 females with I9_HYPTENSPOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 8.06 [4.37, 14.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 292 males with I9_HYPTENSPOR died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSPOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.019% | 1.869% |
| 5 | 5.916% | 9.495% |
| 10 | 14.89% | 22.671% |
| 15 | 26.58% | 39.024% |
| 20 | 41.417% | 57.582% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSPOR – Hypertension, portal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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